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| Mice hemizygous for this transgene are viable and fertile and do not display any gross physical or behavioral abnormalities, even upon aging. This strain may be useful in studies of presynaptic proteins and synaptic vesicles. | |||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.Cg-Tg(THY1-Snca)M1mSud/J (Changed: 30-JUL-08 ) B6.Cg-Tg(THY1-Snca)1Sud/J (Changed: 22-JAN-08 ) Type Mutant Stock; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System Noncarrier x Hemizygote (Female x Male) Species laboratory mouse Generation N5+N1 (13-MAY-08) Donating Investigator Thomas Sudhof, Stanford University School of Medicine Description
Mice hemizygous for this transgene are viable and fertile and do not display any gross physical or behavioral abnormalities, even upon aging. This strain may be useful in studies of presynaptic proteins and synaptic vesicles.Development
This transgenic strain carries the mouse Snca (synuclein, alpha) cDNA under the control of a mouse Thy1 (thymus cell antigen 1, theta) promoter. It is not known what strain the transgenic vector was originally injected into, but this line has been backcrossed approximately five times to C57BL/6.NOTE: A 27 SNP (single nucleotide polymorphism) panel analysis performed by The Jackson Laboratory revealed that this strain is on a mixed STOCK background (four out of 27 markers are segregating for non-C57BL/6 alleles). July, 2008.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Snca
006390 B6;129-Sncatm1Sud Sncbtm1.1Sud/J 003692 B6;129X1-Sncatm1Rosl/J View Strains carrying other alleles of Snca (2 strains)
008473 B6.Cg-Tg(THY1-SNCA*A30P)M30Sud/J 008134 B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J 008474 B6.Cg-Tg(THY1-SNCA*A53T)F53Sud/J 008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J
Phenotype
Phenotype Information
assigned by genotype
Tg(THY1-Snca)M1mSud/0
involves: C57BL/6
- nervous system phenotype
- *normal* nervous system phenotype (MGI Ref ID J:115193)
- mice do not develop motoneuron disease
This mouse can be used to support research in many areas including:
Snca relatedNeurobiology Research
Parkinson's Disease (synuclein mutants)
Neurobiology Research
Parkinson's Disease
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(THY1-Snca)M1mSud | ||
|---|---|---|---|
| Allele Name | transgene insertion M1m, Thomas C Sudhof | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | M1m; Synmtg; | ||
| Expressed Gene | Snca, synuclein, alpha, mouse, laboratory | ||
| Promoter | THY1, Thy-1 cell surface antigen, human | ||
| Molecular Note | The transgene expresses the mouse Snca (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. [MGI Ref ID J:115193] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Sncatm1Sud, STD PCR, vers. 1
Sncbtm1.1Sud, STD PCR, vers. 1
Tg(THY1-Snca), STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Chandra S; Gallardo G; Fernandez-Chacon R; Schluter OM; Sudhof TC. 2005. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123(3):383-96. [PubMed: 16269331] [MGI Ref ID J:115193]
Additional References
Tg(THY1-Snca)M1mSud relatedGallardo G; Schluter OM; Sudhof TC. 2008. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 11(3):301-8. [PubMed: 18297066] [MGI Ref ID J:131733]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Mating System Noncarrier x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $236.40 Female or Male Hemizygous for Tg(THY1-Snca)M1mSud *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $288.65 Hemizygous for Tg(THY1-Snca)M1mSud x Noncarrier $288.65 Noncarrier x Hemizygous for Tg(THY1-Snca)M1mSud
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $307.40 Female or Male Hemizygous for Tg(THY1-Snca)M1mSud *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $375.30 Hemizygous for Tg(THY1-Snca)M1mSud x Noncarrier $375.30 Noncarrier x Hemizygous for Tg(THY1-Snca)M1mSud
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
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Contact information
General inquiries
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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