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| The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease. | |||||||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
Strain Information
Former Names B6.Cg-Tg(THY1-SNCA*A30P)1734Sud/J (Changed: 22-JAN-08 ) Type Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Thomas Sudhof, Stanford University School of Medicine Description
The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile.Development
This transgenic strain carries the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. The transgenic vector was injected into B6SJLF1/J embryos, but this line has been backcrossed approximately 10 times to C57BL/6. This is line TS2.
Related Strains
Strains carrying other alleles of SNCA
008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 004479 B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J 008473 B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J 008474 STOCK Tg(THY1-SNCA*A53T)F53Sud/J View Strains carrying other alleles of SNCA (5 strains)
008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 008473 B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J 008474 STOCK Tg(THY1-SNCA*A53T)F53Sud/J 008132 STOCK Tg(THY1-Snca)M1mSud/J
Phenotype
Phenotype Information
assigned by genotype
Tg(THY1-SNCA*A30P)TS2Sud/0
involves: C57BL/6 * SJL
- nervous system phenotype
- alpha-synuclein inclusion body (MGI Ref ID J:115193)
- insoluble alpha-synuclein aggregates form in asymptomatic and symptomatic transgenic mice in terms of neuropathology
- decreased motor neuron number (MGI Ref ID J:115193)
- motor neuron degeneration (MGI Ref ID J:115193)
- mice show onset of motoneuron disease at ~9-10 months
This mouse can be used to support research in many areas including:
Neurobiology Research
Neurodegeneration
Parkinson's Disease
synuclein mutants
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(THY1-SNCA*A30P)TS2Sud | ||
|---|---|---|---|
| Allele Name | transgene insertion TS2, Thomas C Sudhof | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | TS2; | ||
| Strain of Origin | (C57BL/6J x SJL/J)F1 | ||
| Expressed Gene | SNCA, synuclein, alpha (non A4 component of amyloid precursor), human | ||
| Promoter | THY1, Thy-1 cell surface antigen, human | ||
| Molecular Note | The transgene construct contains the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. [MGI Ref ID J:115193] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(THY1-SNCA*A30P)TS2Sud, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Chandra S; Gallardo G; Fernandez-Chacon R; Schluter OM; Sudhof TC. 2005. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123(3):383-96. [PubMed: 16269331] [MGI Ref ID J:115193]
Additional References
Tg(THY1-SNCA*A30P)TS2Sud relatedGallardo G; Schluter OM; Sudhof TC. 2008. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 11(3):301-8. [PubMed: 18297066] [MGI Ref ID J:131733]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
This strain is currently Under Development for Production.
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Supply Details
| Standard Supply | Under Development for Distribution Colony |
|---|---|
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