Strain Name: |
B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J |
|---|---|
Stock Number: |
008134 |
Availability: | Under Development for Distribution Colony |
| To register your interest in this strain go to the Strain Interest Form. |
General Terms and Conditions |
| Former Name |
B6.Cg-Tg(THY1-SNCA*A30P)1734Sud/J (Changed: 22-JAN-08
) |
| Genes & Alleles | SNCA; THY1; Tg(THY1-SNCA*A30P)TS2Sud; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Transgenic Species laboratory mouse Donating Investigator Thomas Sudhof, U. of Texas, SW Medical Center at Dallas Strain Description
The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile.Strain Development
This transgenic strain carries the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. The transgenic vector was injected into B6SJLF1/J embryos, but this line has been backcrossed approximately 10 times to C57BL/6. This is line TS2.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Tg(THY1-SNCA*A30P)TS2Sud | ||
|---|---|---|---|
| Allele Name | transgene insertion TS2, Thomas C Sudhof | ||
| Common Name(s) | TS2; | ||
| Strain of Origin | (C57BL/6J x SJL/J)F1 | ||
| Expressed Gene | SNCA, synuclein, alpha (non A4 component of amyloid precursor), human | ||
| Promoter | THY1, Thy-1 cell surface antigen, human | ||
| Molecular Note | The transgene construct contains the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. [MGI Ref ID J:115193] | ||
Genotyping Protocols
Tg(THY1-SNCA*A30P)TS2Sud
Related Strains
Strains carrying other alleles of SNCA
008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 004479 B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J View Strains carrying other alleles of SNCA (3 strains)
008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J 008132 STOCK Tg(THY1-Snca)M1mSud/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Neurodegeneration
Parkinson's Disease (synuclein mutants)
References
Selected Reference(s)
Additional ReferencesChandra S; Gallardo G; Fernandez-Chacon R; Schluter OM; Sudhof TC. 2005. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123(3):383-96. [PubMed: 16269331] [MGI Ref ID J:115193]
Price and Supply Information
| Strain Name: | B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J |
| Stock Number: | 008134 |
This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
View All Strains Under Development
Supply Details
| Standard Supply | Under Development for Distribution Colony |
|---|---|
| Supply Notes |
This strain is included in the Induced Mutant Resource Colony collection. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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