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Strain Name:

B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J

Stock Number:

008134

Availability:

Under Development for Distribution Colony

To register your interest in this strain go to the Strain Interest Form.

General Terms and Conditions

Former Name      B6.Cg-Tg(THY1-SNCA*A30P)1734Sud/J    (Changed: 22-JAN-08 )
Genes & Alleles   SNCA;   THY1;   Tg(THY1-SNCA*A30P)TS2Sud;


Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Transgenic
Specieslaboratory mouse
Donating Investigator Thomas Sudhof,   U. of Texas, SW Medical Center at Dallas

Strain Description
The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease. Hemizygous mice are viable and fertile.

Strain Development
This transgenic strain carries the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. The transgenic vector was injected into B6SJLF1/J embryos, but this line has been backcrossed approximately 10 times to C57BL/6. This is line TS2.

Mammalian Phenotype Terms assigned by genotype

Tg(THY1-SNCA*A30P)TS2Sud/0

        involves: C57BL/6
  • nervous system phenotype
  • decreased motor neuron number (MGI Ref ID J:115193)
  • motor neuron degeneration (MGI Ref ID J:115193)
    • mice show onset of motoneuron disease at ~9-10 months

Gene & Allele Details

Allele Symbol Tg(THY1-SNCA*A30P)TS2Sud
Allele Name transgene insertion TS2, Thomas C Sudhof
Common Name(s) TS2;
Strain of Origin(C57BL/6J x SJL/J)F1
Expressed Gene SNCA, synuclein, alpha (non A4 component of amyloid precursor), human
Promoter THY1, Thy-1 cell surface antigen, human
Molecular Note The transgene construct contains the human A30P mutant SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. [MGI Ref ID J:115193]

Genotyping Protocols

Tg(THY1-SNCA*A30P)TS2Sud

Related Strains

Strains carrying other alleles of SNCA
008135   B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J
004479   B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J
008389   C57BL/6-Tg(THY1-SNCA)1Sud/J
View Strains carrying other alleles of SNCA     (3 strains)

Strains carrying other alleles of THY1
008135   B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J
008389   C57BL/6-Tg(THY1-SNCA)1Sud/J
008132   STOCK Tg(THY1-Snca)M1mSud/J
View Strains carrying other alleles of THY1     (3 strains)

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Neurodegeneration
Parkinson's Disease (synuclein mutants)

References

Selected Reference(s)

Chandra S; Gallardo G; Fernandez-Chacon R; Schluter OM; Sudhof TC. 2005. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123(3):383-96. [PubMed: 16269331]  [MGI Ref ID J:115193]

Additional References

Price and Supply Information

Strain Name: B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J
Stock Number: 008134
 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard SupplyUnder Development for Distribution Colony
Supply Notes This strain is included in the Induced Mutant Resource Colony collection.
LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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