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Strain Name:

NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ

Stock Number:

008173

Availability:

Under Development for Distribution Colony

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General Terms and Conditions
Additional Licensing and Use Restrictions

Genes & Alleles   GFP;   Ins1;   Tg(Ins1-EGFP)1Hara;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Transgenic
Mating System+/+ sibling x Hemizygote         (Female x Male)
Specieslaboratory mouse
Background Strain NOD
Donor Strain C57BL/6
Donating Investigator Qizhi Tang,   U of California
H2 Haplotypeg7
GenerationN14+N1 (24-JUN-08)

Appearance
albino
Related Genotype: A/A Tyrc/Tyrc

Strain Description
Mice hemizygous for this "MIP-GFP" transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Green Fluorescent Protein under the control of mouse insulin 1 promoter. Fluorescence is detected in tissues where insulin I is normally expressed; fluorescent protein expression in pancreatic beta-cells is evident from embryonic day (E)13.5 through adult. The human growth hormone sequence in the transgenic insert enhances expression of the EGFP but is not expressed.

The donating investigator reports NOD transgenic female mice develop insulitis and autoimmune diabetes at a similar rate and kenetics as female wildtype controls, 62% and 58% respectively, while surprisingly, transgenic males develop insulitis and diabetes at a higher rate than male wildtype controls, 65% and 10% respectively. This transgenic MIP-GFP mouse strain is useful in studies of diabetes and pancreatic beta islet cell biology.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Strain Development
A transgenic construct containing the coding region of the EGFP gene and a 2.1kb sequence of the human growth hormone to confer high expression of the EGFP, under the control of the mouse insulin 1 gene promoter was injected into fertilized CD1 mouse eggs. Founder line 1 was established on a C57BL/6 background prior to mating to NOD. In 2008, the Type 1 Diabetes Resource received this transgenic NOD strain at generation N14 and mated to NOD/ShiLtJ (Stock No. 001976) for one generation prior to sibling mating.

Gene & Allele Details

Allele Symbol Tg(Ins1-EGFP)1Hara
Allele Name transgene insertion 1, Manami Hara
Common Name(s) MIP-GFP; MIP-GFP (line 1); MIP-GFP (line1); MIP:GFP;
Mutation Made By Manami Hara,   University of Chicago
Strain of OriginCD-1
Site of ExpressionEGFP expression is detected in tissues where insulin I is normally expressed; fluorescent protein expression in pancreatic beta-cells is evident from embryonic day (E)13.5 through adulthood.
Expressed Gene GFP, Green Fluorescent Protein, jellyfish
Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Promoter Ins1, insulin I, mouse, laboratory
Molecular Note A transgenic construct containing the coding region of the EGFP gene and a 2.1kb sequence of the human growth hormone to confer high expression of the EGFP, under the control of the mouse insulin 1 gene promoter (a 8.5 kb region including -8.5 to +12 bp relative to the transcriptional start site) was injected into fertilized CD1 mouse eggs. Founder line 1 was subsequently established. Fluorescence is detected in tissues where insulin I is normally expressed; fluorescent protein expression in pancreatic beta-cells is evident from embryonic day (E)13.5 through adult. [MGI Ref ID J:99450]

Control Information

  Control
   Noncarrier
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

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003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
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View Fluorescent Protein Strains     (145 strains)

Strains carrying   Tg(Ins1-EGFP)1Hara allele
006864   B6.Cg-Tg(Ins1-EGFP)1Hara/J
View Strains carrying   Tg(Ins1-EGFP)1Hara     (1 strain)

Strains carrying other alleles of GFP
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005418   STOCK Tg(HIST1H2BB/EGFP)1Pa/J
003658   STOCK Tg(TIE2GFP)287Sato/J
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View Strains carrying other alleles of GFP     (82 strains)

View Strains carrying other alleles of Ins1     (6 strains)

Additional Web Information

Congenic Nomenclature
Fluorescent Proteins/lacZ Systems

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)

Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)

Research Tools
Diabetes and Obesity Research
Fluorescent Proteins
Genetics Research (Tissue/Cell Markers: pancreatic beta cells)

GFP related

Research Tools
Fluorescent Proteins

Ins1 related

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)

Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)

References

Selected Reference(s)

Chase LG; Ulloa-Montoya F; Kidder BL; Verfaillie CM. 2007. Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56(1):3-7. [PubMed: 17110468]  [MGI Ref ID J:121938]

Hara M; Dizon RF; Glick BS; Lee CS; Kaestner KH; Piston DW; Bindokas VP. 2006. Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab 290(5):E1041-7. [PubMed: 16368785]  [MGI Ref ID J:120245]

Hara M; Wang X; Kawamura T; Bindokas VP; Dizon RF; Alcoser SY; Magnuson MA; Bell GI. 2003. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab 284(1):E177-83. [PubMed: 12388130]  [MGI Ref ID J:99450]

Hauser AE; Junt T; Mempel TR; Sneddon MW; Kleinstein SH; Henrickson SE; von Andrian UH; Shlomchik MJ; Haberman AM. 2007. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26(5):655-67. [PubMed: 17509908]  [MGI Ref ID J:123545]

Additional References

Price and Supply Information

Strain Name: NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
Stock Number: 008173
 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard SupplyUnder Development for Distribution Colony
Supply Notes This strain is included in the Type 1 Diabetes Repository collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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