Strain Name:

STOCK Tg(dlx6a-cre)1Mekk/J

Stock Number:

008199

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Availability:

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These Dlx5/6-Cre transgenic mice have Cre recombinase expression directed by the regulatory sequences of the zebrafish dlx5a/dlx6a genes and may be useful in generating specific deletions of floxed alleles in GABAergic forebrain neurons.

Description

Strain Information

Type Mutant Stock; Transgenic;
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Mating SystemNoncarrier x Hemizygote         (Female x Male)   31-MAR-09
Specieslaboratory mouse
GenerationF?+F10 (18-DEC-13)
Generation Definitions
 
Donating Investigator Marc Ekker,   University of Ottawa

Description
Homozygous Dlx5/6-Cre transgenic mice are viable and fertile. Expression of Cre recombinase (Cre) is directed to differentiating and migrating forebrain GABAergic neurons during embryonic development by the I56i and I56ii enhancers from the zebrafish dlx5a/dlx6a intergenic region (with the 5' promoter region of zebrafish dlx6a in place to increase the activity of the intergenic enhancers rather than direct tissue-specific expression). When Dlx5/6-Cre transgenic mice are bred with mice containing a loxP-flanked sequence, Cre-mediated recombination will result in deletion of the floxed sequence in the offspring. These Dlx5/6-Cre transgenic mice may be useful in generating specific deletions of floxed alleles in GABAergic forebrain neurons.

Development
The Dlx5/6-Cre transgene was designed with a 3.5 kb fragment from the immediate 5'-flanking region of zebrafish dlx6a gene (including part of the 5' UTR) placed immediately upstream of a Cre recombinase coding sequence, all followed by a 1.4 kb enhancer fragment from the zebrafish dlx5a/dlx6a intergenic region (containing both zebrafish I56i and I56ii enhancers). The donating investigator reports that a female founder mouse (founder #8561 on a CD1 genetic background) was bred to CD1 males and the resulting Dlx5/6-Cre mice were maintained by breeding hemizygous males with CD1 females for at least 10 generations prior to arrival at The Jackson Laboratory Repository. Upon arrival, transgenic animals were bred with C57BL/6J mice for at least one generation to establish the colony.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

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008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
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018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
019102   B6N.Cg-Tg(CAG-cre/Esr1*)5Amc/CjDswJ
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
023426   C57BL/6-Tg(Kiss1-cre)J2-4Cfe/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
023407   FVB-HhatTg(TFAP2A-cre)1Will/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
006774   FVB-Tg(Col2a1-cre/ERT)KA3Smac/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
017595   FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
017928   FVB/N-Tg(Mpz-cre)26Mes/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012706   STOCK Ccktm1.1(cre)Zjh/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
007917   STOCK En1tm7(cre/ESR1)Alj/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
010802   STOCK Gad2tm2(cre)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
010530   STOCK Pax7tm1(cre)Mrc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
019378   STOCK Ptf1atm2(cre/ESR1)Cvw/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
008813   STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
008783   STOCK Tg(CAG-cre/Esr1*)5Amc Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J
004453   STOCK Tg(CAG-cre/Esr1*)5Amc/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-cre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (492 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
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      Mutagenesis and Transgenesis: Cre-lox System
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      Tissue/Cell Markers: Cre-lox System
      Tissue/Cell Markers: neurons
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      cell marker

cre related

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      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(dlx6a-cre)1Mekk
Allele Name transgene insertion 1, Marc Ekker
Allele Type Transgenic (Recombinase (cre or Flp) expressing)
Common Name(s) Dlx5/6-Cre; Dlx5/6i-Cre; Tg(dlx6a-cre)1Mars; line 8561;
Mutation Made By Marc Ekker,   University of Ottawa
Strain of OriginCD-1
Site of ExpressionGABAergic forebrain neurons
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter dlx6a, distal-less homeobox gene 6a, Danio rerio,
Driver Note dlx6a
Molecular Note A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sortm1Sor. [MGI Ref ID J:122066]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Monory K; Massa F; Egertova M; Eder M; Blaudzun H; Westenbroek R; Kelsch W; Jacob W; Marsch R; Ekker M; Long J; Rubenstein JL; Goebbels S; Nave KA; During M; Klugmann M; Wolfel B; Dodt HU; Zieglgansberger W; Wotjak CT; Mackie K; Elphick MR; Marsicano G; Lutz B. 2006. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51(4):455-66. [PubMed: 16908411]  [MGI Ref ID J:122066]

Additional References

Tg(dlx6a-cre)1Mekk related

Amendola E; Zhan Y; Mattucci C; Castroflorio E; Calcagno E; Fuchs C; Lonetti G; Silingardi D; Vyssotski AL; Farley D; Ciani E; Pizzorusso T; Giustetto M; Gross CT. 2014. Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. PLoS One 9(5):e91613. [PubMed: 24838000]  [MGI Ref ID J:209635]

Bellocchio L; Lafenetre P; Cannich A; Cota D; Puente N; Grandes P; Chaouloff F; Piazza PV; Marsicano G. 2010. Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci 13(3):281-3. [PubMed: 20139974]  [MGI Ref ID J:158629]

Benard G; Massa F; Puente N; Lourenco J; Bellocchio L; Soria-Gomez E; Matias I; Delamarre A; Metna-Laurent M; Cannich A; Hebert-Chatelain E; Mulle C; Ortega-Gutierrez S; Martin-Fontecha M; Klugmann M; Guggenhuber S; Lutz B; Gertsch J; Chaouloff F; Lopez-Rodriguez ML; Grandes P; Rossignol R; Marsicano G. 2012. Mitochondrial CB(1) receptors regulate neuronal energy metabolism. Nat Neurosci 15(4):558-64. [PubMed: 22388959]  [MGI Ref ID J:191260]

Berghuis P; Rajnicek AM; Morozov YM; Ross RA; Mulder J; Urban GM; Monory K; Marsicano G; Matteoli M; Canty A; Irving AJ; Katona I; Yanagawa Y; Rakic P; Lutz B; Mackie K; Harkany T. 2007. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science 316(5828):1212-6. [PubMed: 17525344]  [MGI Ref ID J:121856]

Chao HT; Chen H; Samaco RC; Xue M; Chahrour M; Yoo J; Neul JL; Gong S; Lu HC; Heintz N; Ekker M; Rubenstein JL; Noebels JL; Rosenmund C; Zoghbi HY. 2010. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263-9. [PubMed: 21068835]  [MGI Ref ID J:166851]

Chiarlone A; Bellocchio L; Blazquez C; Resel E; Soria-Gomez E; Cannich A; Ferrero JJ; Sagredo O; Benito C; Romero J; Sanchez-Prieto J; Lutz B; Fernandez-Ruiz J; Galve-Roperh I; Guzman M. 2014. A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc Natl Acad Sci U S A 111(22):8257-62. [PubMed: 24843137]  [MGI Ref ID J:211357]

Diaz-Alonso J; Aguado T; Wu CS; Palazuelos J; Hofmann C; Garcez P; Guillemot F; Lu HC; Lutz B; Guzman M; Galve-Roperh I. 2012. The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci 32(47):16651-65. [PubMed: 23175820]  [MGI Ref ID J:192580]

Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 MGI Direct Data Submission :.  [MGI Ref ID J:193672]

Haring M; Grieb M; Monory K; Lutz B; Moreira FA. 2013. Cannabinoid CB(1) receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations. Neuropharmacology 65:83-9. [PubMed: 23000076]  [MGI Ref ID J:192754]

Hartman NW; Lin TV; Zhang L; Paquelet GE; Feliciano DM; Bordey A. 2013. mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. Cell Rep 5(2):433-44. [PubMed: 24139800]  [MGI Ref ID J:203767]

Hays SA; Huber KM; Gibson JR. 2011. Altered Neocortical Rhythmic Activity States in Fmr1 KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry. J Neurosci 31(40):14223-34. [PubMed: 21976507]  [MGI Ref ID J:177183]

Hou XJ; Ni KM; Yang JM; Li XM. 2014. Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses. Neuroscience 261:107-17. [PubMed: 24374327]  [MGI Ref ID J:208003]

Kohwi M; Petryniak MA; Long JE; Ekker M; Obata K; Yanagawa Y; Rubenstein JL; Alvarez-Buylla A. 2007. A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci 27(26):6878-91. [PubMed: 17596436]  [MGI Ref ID J:160206]

Kuhne C; Puk O; Graw J; Hrabe de Angelis M; Schutz G; Wurst W; Deussing JM. 2012. Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol 520(14):3150-80. [PubMed: 22886732]  [MGI Ref ID J:187372]

Li G; Adesnik H; Li J; Long J; Nicoll RA; Rubenstein JL; Pleasure SJ. 2008. Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci 28(5):1085-98. [PubMed: 18234887]  [MGI Ref ID J:131835]

Li Y; Hibbs MA; Gard AL; Shylo NA; Yun K. 2012. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells 30(4):741-52. [PubMed: 22232070]  [MGI Ref ID J:190509]

Li Y; Yui D; Luikart BW; McKay RM; Li Y; Rubenstein JL; Parada LF. 2012. Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development. Proc Natl Acad Sci U S A 109(38):15491-6. [PubMed: 22949667]  [MGI Ref ID J:190151]

Lokmane L; Proville R; Narboux-Neme N; Gyory I; Keita M; Mailhes C; Lena C; Gaspar P; Grosschedl R; Garel S. 2013. Sensory map transfer to the neocortex relies on pretarget ordering of thalamic axons. Curr Biol 23(9):810-6. [PubMed: 23623550]  [MGI Ref ID J:199727]

Lourenco J; Cannich A; Carta M; Coussen F; Mulle C; Marsicano G. 2010. Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses. Nat Neurosci 13(2):197-204. [PubMed: 20081851]  [MGI Ref ID J:156676]

Lu A; Steiner MA; Whittle N; Vogl AM; Walser SM; Ableitner M; Refojo D; Ekker M; Rubenstein JL; Stalla GK; Singewald N; Holsboer F; Wotjak CT; Wurst W; Deussing JM. 2008. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry 13(11):1028-42. [PubMed: 18475271]  [MGI Ref ID J:149207]

Massa F; Mancini G; Schmidt H; Steindel F; Mackie K; Angioni C; Oliet SH; Geisslinger G; Lutz B. 2010. Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. J Neurosci 30(18):6273-81. [PubMed: 20445053]  [MGI Ref ID J:160561]

Metna-Laurent M; Soria-Gomez E; Verrier D; Conforzi M; Jego P; Lafenetre P; Marsicano G. 2012. Bimodal Control of Fear-Coping Strategies by CB1 Cannabinoid Receptors. J Neurosci 32(21):7109-18. [PubMed: 22623656]  [MGI Ref ID J:184981]

Monory K; Blaudzun H; Massa F; Kaiser N; Lemberger T; Schutz G; Wotjak CT; Lutz B; Marsicano G. 2007. Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol 5(10):e269. [PubMed: 17927447]  [MGI Ref ID J:128453]

Narboux-Neme N; Goiame R; Mattei MG; Cohen-Tannoudji M; Wassef M. 2012. Integration of H-2Z1, a Somatosensory Cortex-Expressed Transgene, Interferes with the Expression of the Satb1 and Tbc1d5 Flanking Genes and Affects the Differentiation of a Subset of Cortical Interneurons. J Neurosci 32(21):7287-7300. [PubMed: 22623674]  [MGI Ref ID J:184976]

Ohtsuka N; Tansky MF; Kuang H; Kourrich S; Thomas MJ; Rubenstein JL; Ekker M; Leeman SE; Tsien JZ. 2008. Functional disturbances in the striatum by region-specific ablation of NMDA receptors. Proc Natl Acad Sci U S A 105(35):12961-6. [PubMed: 18728179]  [MGI Ref ID J:139133]

Refojo D; Schweizer M; Kuehne C; Ehrenberg S; Thoeringer C; Vogl AM; Dedic N; Schumacher M; von Wolff G; Avrabos C; Touma C; Engblom D; Schutz G; Nave KA; Eder M; Wotjak CT; Sillaber I; Holsboer F; Wurst W; Deussing JM. 2011. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science 333(6051):1903-7. [PubMed: 21885734]  [MGI Ref ID J:176339]

Sanchez-Ortiz E; Yui D; Song D; Li Y; Rubenstein JL; Reichardt LF; Parada LF. 2012. TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry. J Neurosci 32(12):4065-79. [PubMed: 22442072]  [MGI Ref ID J:183467]

Shen HY; Canas PM; Garcia-Sanz P; Lan JQ; Boison D; Moratalla R; Cunha RA; Chen JF. 2013. Adenosine A(2)A receptors in striatal glutamatergic terminals and GABAergic neurons oppositely modulate psychostimulant action and DARPP-32 phosphorylation. PLoS One 8(11):e80902. [PubMed: 24312250]  [MGI Ref ID J:209756]

Shen HY; Coelho JE; Ohtsuka N; Canas PM; Day YJ; Huang QY; Rebola N; Yu L; Boison D; Cunha RA; Linden J; Tsien JZ; Chen JF. 2008. A critical role of the adenosine A2A receptor in extrastriatal neurons in modulating psychomotor activity as revealed by opposite phenotypes of striatum and forebrain A2A receptor knock-outs. J Neurosci 28(12):2970-5. [PubMed: 18354001]  [MGI Ref ID J:133212]

Singer P; Wei CJ; Chen JF; Boison D; Yee BK. 2013. Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning. Behav Brain Res 242:54-61. [PubMed: 23276608]  [MGI Ref ID J:197065]

Steindel F; Lerner R; Haring M; Ruehle S; Marsicano G; Lutz B; Monory K. 2013. Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus. J Neurochem 124(6):795-807. [PubMed: 23289830]  [MGI Ref ID J:193914]

Wei CJ; Augusto E; Gomes CA; Singer P; Wang Y; Boison D; Cunha RA; Yee BK; Chen JF. 2013. Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A Receptors in Forebrain. Biol Psychiatry :. [PubMed: 23820821]  [MGI Ref ID J:199140]

Yang JM; Zhang J; Chen XJ; Geng HY; Ye M; Spitzer NC; Luo JH; Duan SM; Li XM. 2013. Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice. J Neurosci 33(50):19724-33. [PubMed: 24336736]  [MGI Ref ID J:205489]

Yee CL; Wang Y; Anderson S; Ekker M; Rubenstein JL. 2009. Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y(+), proopiomelanocortin(+), and tyrosine hydroxylase(+) neurons in neonatal and adult mice. J Comp Neurol 517(1):37-50. [PubMed: 19711380]  [MGI Ref ID J:161578]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, the donating investigator breeds hemizygotes with noncarrier (wildtype) siblings.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   31-MAR-09
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(dlx6a-cre)1Mekk  
Price per Pair (US dollars $)Pair Genotype
$311.00Hemizygous for Tg(dlx6a-cre)1Mekk x Noncarrier  
$311.00Noncarrier x Hemizygous for Tg(dlx6a-cre)1Mekk  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(dlx6a-cre)1Mekk  
Price per Pair (US dollars $)Pair Genotype
$404.30Hemizygous for Tg(dlx6a-cre)1Mekk x Noncarrier  
$404.30Noncarrier x Hemizygous for Tg(dlx6a-cre)1Mekk  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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