Strain Name:

(C57BL/6-Tg(TRAMP)8247Ng/J x FVB/NJ)F1/J

Stock Number:


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Common Names: TRAMP;    
These mice express the TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) transgene and develop progressive forms of prostate cancer with distant site metastasis. An earlier onset of the phenotype is observed in these F1 background mice when compared to mice carrying the transgene on the C57BL/6 background.


Strain Information

Type Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Type F1 or F2 Hybrid;
Additional information on Hybrid Strains.
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Mating SystemHemizygote x Inbred         (Female x Male)   04-APR-08
Specieslaboratory mouse
GenerationF1 (04-JUN-14)
Generation Definitions
Donating Investigator IMR Colony,   The Jackson Laboratory

Mice carrying the TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) transgene develop progressive forms of prostate cancer with distant site metastasis, primarily to the lymph nodes and lungs. These transgenic mice express the simian virus 40 (SV40) large T and small t tumor antigens (Tag) under the control of the rat probasin promoter. Expression of the transgene is specific to the prostate epithelium. Transgenic mice exhibit various forms of disease from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. The median survival time for these F1 transgenic mice is 19 weeks, very few mice survive past 33 weeks of age, which is significantly shorter than the lifespan of transgenic mice on the C57BL/6 background. Comparative histological analysis of tumors from these F1 transgenic mice and from transgenic mice on the C57BL/6 background reveals that the tumors found in these F1 mutants arise from the dorsolateral and ventral lobes of the prostate and are more spherical, highly vascularized masses. The tumors found in the C57BL/6 background transgenic mice arise from the prostate lateral lobes and often invade the surrounding tissues (urethra and seminal vesicles).

The TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) transgenic construct, containing simian virus 40 (SV40) early genes (large (T) and small(t) tumor antigens, Tag) under the control of the rat probasin promoter, was injected into fertilized C57BL/6 mouse eggs. Founder line 8247 was established. To generate this F1 strain, TRAMP transgenic females (Stock No. 003135) are mated with FVB/NJ males (Stock No. 001800).

Control Information

   See control note: The genetic background control is (C57BL/6J x FVB/NJ)F1 hybrid mice (Stock No. 019019). This F1 is created by breeding C57BL/6J females (Stock No. 000664) with FVB/NJ males (Stock No. 001800).
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(TRAMP)8247Ng allele
003135   C57BL/6-Tg(TRAMP)8247Ng/J
View Strains carrying   Tg(TRAMP)8247Ng     (1 strain)

View Strains carrying other alleles of TAg     (15 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Prostate Cancer
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S1/Sv * C57BL/6
  • tumorigenesis
  • increased prostate gland tumor incidence   (MGI Ref ID J:108849)


        involves: C57BL/6
  • tumorigenesis
  • increased prostate gland adenocarcinoma incidence
    • males display focal and invasive adenocarcinoma of the prostate by 20 weeks   (MGI Ref ID J:65303)
  • reproductive system phenotype
  • prostate gland hyperplasia
    • intraepithelial hyperplasia can be detected in males by 10 weeks of age and by 22 weeks of age, almost all prostatic glands are hyperplastic   (MGI Ref ID J:65303)
  • endocrine/exocrine gland phenotype
  • prostate gland hyperplasia
    • intraepithelial hyperplasia can be detected in males by 10 weeks of age and by 22 weeks of age, almost all prostatic glands are hyperplastic   (MGI Ref ID J:65303)


        involves: C3H * C57BL/6
  • endocrine/exocrine gland phenotype
  • increased prostate gland weight
    • prostates weigh an average of >6g, while in transgenic mice expressing the Tg(ACTB-SAC/EGFP)35Rang transgene, most (78.5%) prostate glands weigh <2g and remaining 21.5% weigh between 2 and 3 grams   (MGI Ref ID J:125633)
  • reproductive system phenotype
  • increased prostate gland weight
    • prostates weigh an average of >6g, while in transgenic mice expressing the Tg(ACTB-SAC/EGFP)35Rang transgene, most (78.5%) prostate glands weigh <2g and remaining 21.5% weigh between 2 and 3 grams   (MGI Ref ID J:125633)
  • tumorigenesis
  • increased prostate gland tumor incidence
    • majority (62.5-83.3%) of mice develop high-grade prostatic intraepithelial neoplasia by 3 months of age and 12-16% of animals show adenocarcinoma of the prostate; by 6 months, all mice develop adenocarcinoma of the prostate   (MGI Ref ID J:125633)
    • increased prostate gland adenocarcinoma incidence   (MGI Ref ID J:125633)
    • increased prostate intraepithelial neoplasia incidence   (MGI Ref ID J:125633)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Apoptosis Research
Extracellular Modulators

Cancer Research
Increased Tumor Incidence
      Prostate Tumors
      tumor metastasis

Reproductive Biology Research
Prostate Tumors

Research Tools
Cancer Research
      tumor immunology

TAg related

Apoptosis Research
Extracellular Modulators

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(TRAMP)8247Ng
Allele Name transgene insertion 8247, Norman M Greenberg
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) PB-Tag; TRAMP; probasin/Tag;
Mutation Made ByDr. Norman Greenberg,   Pfizer Global Research and Development
Strain of OriginC57BL/6
Expressed Gene TAg, SV40 large T-antigen, SV40
Simian virus 40 T antigen (SV40Tag) is a multifunctional regulatory protein that stimulates gene transcription and forms complexes with cell cycle-regulatory proteins such as Trp53 and Rb1 that are implicated in human breast cancer.
Promoter Pb, probasin, rat
General Note TRAMP stands for TRansgenic Adenocarcinoma Mouse Prostate. Lines 5666 and 8079 were also produced.

Transgenic mice on a C57BL6 background develop progressive forms of prostate cancer with distant site metastasis. Forms ofdisease range from mild intraepithelial hyperplasia to large multinodular malignant neoplasia. Tumors are detected in the prostate as early as 10 weeks of age. The tumors have elevated levels of nuclear TRP53 and decreased androgen receptor expression.

Molecular Note Expression of the SV40 early region tumor antigen was driven in mouse prostrate epithelium via a rat probasin promoter region fragment (-426/+28 bp). [MGI Ref ID J:65303] [MGI Ref ID J:73560]


Genotyping Information

Genotyping Protocols

Generic SV40, MELT
Tg(Tramp1), Standard PCR
Tg(Tramp2), Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Greenberg NM; DeMayo F; Finegold MJ; Medina D; Tilley WD; Aspinall JO; Cunha GR; Donjacour AA; Matusik RJ; Rosen JM. 1995. Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A 92(8):3439-43. [PubMed: 7724580]  [MGI Ref ID J:65303]

Huss WJ; Maddison LA; Greenberg NM. 2001. Autochthonous mouse models for prostate cancer: past, present and future. Semin Cancer Biol 11(3):245-60. [PubMed: 11407949]  [MGI Ref ID J:78291]

Additional References

Tg(TRAMP)8247Ng related

Abdulkadir SA; Qu Z; Garabedian E; Song SK; Peters TJ; Svaren J; Carbone JM; Naughton CK; Catalona WJ; Ackerman JJ; Gordon JI; Humphrey PA; Milbrandt J. 2001. Impaired prostate tumorigenesis in Egr1-deficient mice. Nat Med 7(1):101-7. [PubMed: 11135623]  [MGI Ref ID J:67125]

Abrate A; Buono R; Canu T; Esposito A; Del Maschio A; Luciano R; Bettiga A; Colciago G; Guazzoni G; Benigni F; Hedlund P; Altaner C; Montorsi F; Cavarretta IT. 2014. Mesenchymal stem cells expressing therapeutic genes induce autochthonous prostate tumour regression. Eur J Cancer 50(14):2478-88. [PubMed: 25060826]  [MGI Ref ID J:214612]

Adhami VM; Siddiqui IA; Ahmad N; Gupta S; Mukhtar H. 2004. Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer. Cancer Res 64(23):8715-22. [PubMed: 15574782]  [MGI Ref ID J:94677]

Adhami VM; Siddiqui IA; Syed DN; Lall RK; Mukhtar H. 2012. Oral infusion of pomegranate fruit extract inhibits prostate carcinogenesis in the TRAMP model. Carcinogenesis 33(3):644-51. [PubMed: 22198212]  [MGI Ref ID J:181504]

Ajibade AA; Kirk JS; Karasik E; Gillard B; Moser MT; Johnson CS; Trump DL; Foster BA. 2014. Early growth inhibition is followed by increased metastatic disease with vitamin D (calcitriol) treatment in the TRAMP model of prostate cancer. PLoS One 9(2):e89555. [PubMed: 24586868]  [MGI Ref ID J:213817]

Albers MJ; Bok R; Chen AP; Cunningham CH; Zierhut ML; Zhang VY; Kohler SJ; Tropp J; Hurd RE; Yen YF; Nelson SJ; Vigneron DB; Kurhanewicz J. 2008. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 68(20):8607-15. [PubMed: 18922937]  [MGI Ref ID J:140550]

Albertelli MA; O'Mahony OA; Brogley M; Tosoian J; Steinkamp M; Daignault S; Wojno K; Robins DM. 2008. Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice. Hum Mol Genet 17(1):98-110. [PubMed: 17906287]  [MGI Ref ID J:132039]

Albertelli MA; Scheller A; Brogley M; Robins DM. 2006. Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol Endocrinol 20(6):1248-60. [PubMed: 16601069]  [MGI Ref ID J:108849]

Ammirante M; Luo JL; Grivennikov S; Nedospasov S; Karin M. 2010. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464(7286):302-5. [PubMed: 20220849]  [MGI Ref ID J:157973]

Ammirante M; Shalapour S; Kang Y; Jamieson CA; Karin M. 2014. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A 111(41):14776-81. [PubMed: 25267627]  [MGI Ref ID J:216445]

Anzo M; Cobb LJ; Hwang DL; Mehta H; Said JW; Yakar S; LeRoith D; Cohen P. 2008. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res 68(9):3342-9. [PubMed: 18451161]  [MGI Ref ID J:134610]

Azzali G. 2007. Tumor cell transendothelial passage in the absorbing lymphatic vessel of transgenic adenocarcinoma mouse prostate. Am J Pathol 170(1):334-46. [PubMed: 17200205]  [MGI Ref ID J:117198]

Bao Y; Peng W; Verbitsky A; Chen J; Wu L; Rauen KA; Sawicki JA. 2005. Human coxsackie adenovirus receptor (CAR) expression in transgenic mouse prostate tumors enhances adenoviral delivery of genes. Prostate 64(4):401-7. [PubMed: 15761871]  [MGI Ref ID J:100079]

Barthel SR; Hays DL; Yazawa EM; Opperman M; Walley KC; Nimrichter L; Burdick MM; Gillard BM; Moser MT; Pantel K; Foster BA; Pienta KJ; Dimitroff CJ. 2013. Definition of molecular determinants of prostate cancer cell bone extravasation. Cancer Res 73(2):942-52. [PubMed: 23149920]  [MGI Ref ID J:194105]

Barve A; Khor TO; Nair S; Reuhl K; Suh N; Reddy B; Newmark H; Kong AN. 2009. Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice. Int J Cancer 124(7):1693-9. [PubMed: 19115203]  [MGI Ref ID J:147509]

Basu HS; Thompson TA; Church DR; Clower CC; Mehraein-Ghomi F; Amlong CA; Martin CT; Woster PM; Lindstrom MJ; Wilding G. 2009. A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res 69(19):7689-95. [PubMed: 19773450]  [MGI Ref ID J:153608]

Bellone M; Ceccon M; Grioni M; Jachetti E; Calcinotto A; Napolitano A; Freschi M; Casorati G; Dellabona P. 2010. iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells. PLoS One 5(1):e8646. [PubMed: 20072624]  [MGI Ref ID J:157237]

Bendle GM; Linnemann C; Bies L; Song JY; Schumacher TN. 2013. Blockade of TGF-beta signaling greatly enhances the efficacy of TCR gene therapy of cancer. J Immunol 191(6):3232-9. [PubMed: 23940272]  [MGI Ref ID J:205767]

Bettuzzi S; Davalli P; Davoli S; Chayka O; Rizzi F; Belloni L; Pellacani D; Fregni G; Astancolle S; Fassan M; Corti A; Baffa R; Sala A. 2009. Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread. Oncogene 28(49):4344-52. [PubMed: 19784068]  [MGI Ref ID J:157040]

Bianchi-Frias D; Hernandez SA; Coleman R; Wu H; Nelson PS. 2015. The landscape of somatic chromosomal copy number aberrations in GEM models of prostate carcinoma. Mol Cancer Res 13(2):339-47. [PubMed: 25298407]  [MGI Ref ID J:219675]

Bok RA; Hansell EJ; Nguyen TP; Greenberg NM; McKerrow JH; Shuman MA. 2003. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis 6(4):272-80. [PubMed: 14663466]  [MGI Ref ID J:100578]

Bono AV; Montironi R; Pannellini T; Sasso F; Mirone V; Musiani P; Iezzi M. 2008. Effects of castration on the development of prostate adenocarcinoma from its precursor HGPIN and on the occurrence of androgen-independent, poorly differentiated carcinoma in TRAMP mice. Prostate Cancer Prostatic Dis 11(4):377-83. [PubMed: 18379588]  [MGI Ref ID J:155788]

Bradley SV; Oravecz-Wilson KI; Bougeard G; Mizukami I; Li L; Munaco AJ; Sreekumar A; Corradetti MN; Chinnaiyan AM; Sanda MG; Ross TS. 2005. Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer. Cancer Res 65(10):4126-33. [PubMed: 15899803]  [MGI Ref ID J:98551]

Bruckheimer EM; Brisbay S; Johnson DJ; Gingrich JR; Greenberg N; McDonnell TJ. 2000. Bcl-2 accelerates multistep prostate carcinogenesis in vivo Oncogene 19(46):5251-8. [PubMed: 11077442]  [MGI Ref ID J:65876]

Calcinotto A; Grioni M; Jachetti E; Curnis F; Mondino A; Parmiani G; Corti A; Bellone M. 2012. Targeting TNF-alpha to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy. J Immunol 188(6):2687-94. [PubMed: 22323546]  [MGI Ref ID J:181852]

Caporali A; Davalli P; Astancolle S; D'Arca D; Brausi M; Bettuzzi S; Corti A. 2004. The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. Carcinogenesis 25(11):2217-24. [PubMed: 15358631]  [MGI Ref ID J:93777]

Chae YC; Caino MC; Lisanti S; Ghosh JC; Dohi T; Danial NN; Villanueva J; Ferrero S; Vaira V; Santambrogio L; Bosari S; Languino LR; Herlyn M; Altieri DC. 2012. Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell 22(3):331-44. [PubMed: 22975376]  [MGI Ref ID J:192906]

Chang C; Lee SO; Yeh S; Chang TM. 2014. Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver. Oncogene 33(25):3225-34. [PubMed: 23873027]  [MGI Ref ID J:212618]

Chen X; Corbin JM; Tipton GJ; Yang LV; Asch AS; Ruiz-Echevarria MJ. 2014. The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta 1843(6):1216-24. [PubMed: 24632071]  [MGI Ref ID J:212490]

Chiaverotti T; Couto SS; Donjacour A; Mao JH; Nagase H; Cardiff RD; Cunha GR; Balmain A. 2008. Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol 172(1):236-46. [PubMed: 18156212]  [MGI Ref ID J:130924]

Chin AI; Miyahira AK; Covarrubias A; Teague J; Guo B; Dempsey PW; Cheng G. 2010. Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res 70(7):2595-603. [PubMed: 20233880]  [MGI Ref ID J:158910]

Chou CK; Schietinger A; Liggitt HD; Tan X; Funk S; Freeman GJ; Ratliff TL; Greenberg NM; Greenberg PD. 2012. Cell-intrinsic abrogation of TGF-beta signaling delays but does not prevent dysfunction of self/tumor-specific CD8 T cells in a murine model of autochthonous prostate cancer. J Immunol 189(8):3936-46. [PubMed: 22984076]  [MGI Ref ID J:190653]

Chung AC; Zhou S; Liao L; Tien JC; Greenberg NM; Xu J. 2007. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res 67(12):5965-75. [PubMed: 17575167]  [MGI Ref ID J:122392]

Collazo J; Zhu B; Larkin S; Martin SK; Pu H; Horbinski C; Koochekpour S; Kyprianou N. 2014. Cofilin drives cell-invasive and metastatic responses to TGF-beta in prostate cancer. Cancer Res 74(8):2362-73. [PubMed: 24509905]  [MGI Ref ID J:210536]

Copeland BT; Bowman MJ; Ashman LK. 2013. Genetic ablation of the tetraspanin CD151 reduces spontaneous metastatic spread of prostate cancer in the TRAMP model. Mol Cancer Res 11(1):95-105. [PubMed: 23131993]  [MGI Ref ID J:205380]

Copeland BT; Bowman MJ; Boucheix C; Ashman LK. 2013. Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner. Int J Cancer 133(8):1803-12. [PubMed: 23575960]  [MGI Ref ID J:199938]

Cowell JK; Head K; Kunapuli P; Vaughan M; Karasik E; Foster B. 2010. Inactivation of LGI1 expression accompanies early stage hyperplasia of prostate epithelium in the TRAMP murine model of prostate cancer. Exp Mol Pathol 88(1):77-81. [PubMed: 19778537]  [MGI Ref ID J:163951]

Deeb D; Gao X; Liu Y; Jiang D; Divine GW; Arbab AS; Dulchavsky SA; Gautam SC. 2011. Synthetic triterpenoid CDDO prevents the progression and metastasis of prostate cancer in TRAMP mice by inhibiting survival signaling. Carcinogenesis 32(5):757-64. [PubMed: 21325633]  [MGI Ref ID J:171462]

Deeb KK; Michalowska AM; Yoon CY; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li MC; Demayo FJ; Linnoila I; Deng CX; Lee EY; Medina D; Shih JH; Green JE. 2007. Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis. Cancer Res 67(17):8065-8080. [PubMed: 17804718]  [MGI Ref ID J:124885]

Degl'Innocenti E; Grioni M; Capuano G; Jachetti E; Freschi M; Bertilaccio MT; Hess-Michelini R; Doglioni C; Bellone M. 2008. Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+CD25+ regulatory T cells. Cancer Res 68(1):292-300. [PubMed: 18172322]  [MGI Ref ID J:131032]

Degl'innocenti E; Grioni M; Boni A; Camporeale A; Bertilaccio MT; Freschi M; Monno A; Arcelloni C; Greenberg NM; Bellone M. 2004. Peripheral T cell tolerance occurs early during spontaneous prostate cancer development and can be rescued by dendritic cell immunization. Eur J Immunol 35(1):66-75. [PubMed: 15597325]  [MGI Ref ID J:95463]

Diener KR; Woods AE; Manavis J; Brown MP; Hayball JD. 2009. Transforming growth factor-beta-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression. Lab Invest 89(2):142-51. [PubMed: 19079323]  [MGI Ref ID J:144222]

Donkor MK; Sarkar A; Savage PA; Franklin RA; Johnson LK; Jungbluth AA; Allison JP; Li MO. 2011. T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-beta1 Cytokine. Immunity 35(1):123-34. [PubMed: 21757379]  [MGI Ref ID J:174515]

Drake CG; Doody AD; Mihalyo MA; Huang CT; Kelleher E; Ravi S; Hipkiss EL; Flies DB; Kennedy EP; Long M; McGary PW; Coryell L; Nelson WG; Pardoll DM; Adler AJ. 2005. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 7(3):239-49. [PubMed: 15766662]  [MGI Ref ID J:96922]

Dubey P; Wu H; Reiter RE; Witte ON. 2001. Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res 61(8):3256-61. [PubMed: 11309275]  [MGI Ref ID J:69227]

Dudley AC; Khan ZA; Shih SC; Kang SY; Zwaans BM; Bischoff J; Klagsbrun M. 2008. Calcification of multipotent prostate tumor endothelium. Cancer Cell 14(3):201-11. [PubMed: 18772110]  [MGI Ref ID J:141163]

Dudley AC; Udagawa T; Melero-Martin JM; Shih SC; Curatolo A; Moses MA; Klagsbrun M. 2010. Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood 116(17):3367-71. [PubMed: 20453162]  [MGI Ref ID J:165908]

El Touny LH; Banerjee PP. 2009. Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis. Cancer Res 69(8):3695-703. [PubMed: 19351854]  [MGI Ref ID J:147723]

Ende N; Chen R; Reddi AS. 2006. Administration of human umbilical cord blood cells delays the onset of prostate cancer and increases the lifespan of the TRAMP mouse. Cancer Lett 231(1):123-8. [PubMed: 16356837]  [MGI Ref ID J:104030]

Eng MH; Charles LG; Ross BD; Chrisp CE; Pienta KJ; Greenberg NM; Hsu CX; Sanda MG. 1999. Early castration reduces prostatic carcinogenesis in transgenic mice Urology 54(6):1112-9. [PubMed: 10604719]  [MGI Ref ID J:59577]

Fendt SM; Bell EL; Keibler MA; Davidson SM; Wirth GJ; Fiske B; Mayers JR; Schwab M; Bellinger G; Csibi A; Patnaik A; Blouin MJ; Cantley LC; Guarente L; Blenis J; Pollak MN; Olumi AF; Vander Heiden MG; Stephanopoulos G. 2013. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism. Cancer Res 73(14):4429-4438. [PubMed: 23687346]  [MGI Ref ID J:199118]

Feng S; Agoulnik IU; Bogatcheva NV; Kamat AA; Kwabi-Addo B; Li R; Ayala G; Ittmann MM; Agoulnik AI. 2007. Relaxin promotes prostate cancer progression. Clin Cancer Res 13(6):1695-702. [PubMed: 17363522]  [MGI Ref ID J:122670]

Finegan KG; Tournier C. 2010. The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer. Cancer Res 70(14):5797-806. [PubMed: 20610622]  [MGI Ref ID J:162248]

Foster BA; Gingrich JR; Kwon ED; Madias C; Greenberg NM. 1997. Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Cancer Res 57(16):3325-30. [PubMed: 9269988]  [MGI Ref ID J:42333]

Foster BA; Kaplan PJ; Greenberg NM. 1999. Characterization of the FGF axis and identification of a novel FGFR1iiic isoform during prostate cancer progression in the TRAMP model. Prostate Cancer Prostatic Dis 2(2):76-82. [PubMed: 12496842]  [MGI Ref ID J:84412]

Fricke ST; Rodriguez O; Vanmeter J; Dettin LE; Casimiro M; Chien CD; Newell T; Johnson K; Ileva L; Ojeifo J; Johnson MD; Albanese C. 2006. In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models. Prostate 66(7):708-17. [PubMed: 16425198]  [MGI Ref ID J:110412]

Fritz WA; Lin TM; Cardiff RD; Peterson RE. 2007. The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice. Carcinogenesis 28(2):497-505. [PubMed: 17052998]  [MGI Ref ID J:118152]

Fritz WA; Lin TM; Peterson RE. 2008. The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates. Carcinogenesis 29(5):1077-82. [PubMed: 18359762]  [MGI Ref ID J:138497]

Galea I; Stasakova J; Dunscombe MS; Ottensmeier CH; Elliott T; Thirdborough SM. 2012. CD8(+) T-cell cross-competition is governed by peptide-MHC class I stability. Eur J Immunol 42(1):256-63. [PubMed: 22002320]  [MGI Ref ID J:179828]

Garcia GE; Wisniewski HG; Lucia MS; Arevalo N; Slaga TJ; Kraft SL; Strange R; Kumar AP. 2006. 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. Clin Cancer Res 12(3 Pt 1):980-8. [PubMed: 16467113]  [MGI Ref ID J:107341]

Gelman IH; Peresie J; Eng KH; Foster BA. 2014. Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancer. Mol Cancer Res 12(10):1470-9. [PubMed: 25053806]  [MGI Ref ID J:215994]

Gingrich JR; Barrios RJ; Foster BA; Greenberg NM. 1999. Pathologic progression of autochthonous prostate cancer in the TRAMP model. Prostate Cancer Prostatic Dis 2(2):70-75. [PubMed: 12496841]  [MGI Ref ID J:66957]

Gingrich JR; Barrios RJ; Kattan MW; Nahm HS; Finegold MJ; Greenberg NM. 1997. Androgen-independent prostate cancer progression in the TRAMP model. Cancer Res 57(21):4687-91. [PubMed: 9354422]  [MGI Ref ID J:65305]

Gingrich JR; Barrios RJ; Morton RA; Boyce BF; DeMayo FJ; Finegold MJ; Angelopoulou R; Rosen JM; Greenberg NM. 1996. Metastatic prostate cancer in a transgenic mouse. Cancer Res 56(18):4096-102. [PubMed: 8797572]  [MGI Ref ID J:65304]

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Polnaszek N; Kwabi-Addo B; Peterson LE; Ozen M; Greenberg NM; Ortega S; Basilico C; Ittmann M. 2003. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Cancer Res 63(18):5754-60. [PubMed: 14522896]  [MGI Ref ID J:86075]

Pu H; Collazo J; Jones E; Gayheart D; Sakamoto S; Vogt A; Mitchell B; Kyprianou N. 2009. Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model. Cancer Res 69(18):7366-74. [PubMed: 19738062]  [MGI Ref ID J:152684]

Pu H; Horbinski C; Hensley PJ; Matuszak EA; Atkinson T; Kyprianou N. 2014. PARP-1 regulates epithelial-mesenchymal transition (EMT) in prostate tumorigenesis. Carcinogenesis 35(11):2592-601. [PubMed: 25173886]  [MGI Ref ID J:216690]

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Qi J; Nakayama K; Cardiff RD; Borowsky AD; Kaul K; Williams R; Krajewski S; Mercola D; Carpenter PM; Bowtell D; Ronai ZA. 2010. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell 18(1):23-38. [PubMed: 20609350]  [MGI Ref ID J:161781]

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Shukla S; Bhaskaran N; Babcook MA; Fu P; Maclennan GT; Gupta S. 2014. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis 35(2):452-60. [PubMed: 24067903]  [MGI Ref ID J:205414]

Shukla S; MacLennan GT; Flask CA; Fu P; Mishra A; Resnick MI; Gupta S. 2007. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res 67(14):6925-35. [PubMed: 17638904]  [MGI Ref ID J:123137]

Siddique HR; Adhami VM; Parray A; Johnson JJ; Siddiqui IA; Shekhani MT; Murtaza I; Ambartsumian N; Konety BR; Mukhtar H; Saleem M. 2013. The S100A4 Oncoprotein Promotes Prostate Tumorigenesis in a Transgenic Mouse Model: Regulating NFkappaB through the RAGE Receptor. Genes Cancer 4(5-6):224-34. [PubMed: 24069509]  [MGI Ref ID J:202464]

Siddiqui IA; Shukla Y; Adhami VM; Sarfaraz S; Asim M; Hafeez BB; Mukhtar H. 2008. Suppression of NFkappaB and its Regulated Gene Products by Oral Administration of Green Tea Polyphenols in an Autochthonous Mouse Prostate Cancer Model. Pharm Res 25(9):2135-42. [PubMed: 18317887]  [MGI Ref ID J:138094]

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Slusarz A; Jackson GA; Day JK; Shenouda NS; Bogener JL; Browning JD; Fritsche KL; MacDonald RS; Besch-Williford CL; Lubahn DB. 2012. Aggressive prostate cancer is prevented in ERalphaKO mice and stimulated in ERbetaKO TRAMP mice. Endocrinology 153(9):4160-70. [PubMed: 22753646]  [MGI Ref ID J:189182]

Slusarz A; Shenouda NS; Sakla MS; Drenkhahn SK; Narula AS; MacDonald RS; Besch-Williford CL; Lubahn DB. 2010. Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer. Cancer Res 70(8):3382-90. [PubMed: 20395211]  [MGI Ref ID J:158939]

Stagg J; Beavis PA; Divisekera U; Liu MC; Moller A; Darcy PK; Smyth MJ. 2012. CD73-deficient mice are resistant to carcinogenesis. Cancer Res 72(9):2190-6. [PubMed: 22396496]  [MGI Ref ID J:185750]

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Suttie A; Nyska A; Haseman JK; Moser GJ; Hackett TR; Goldsworthy TL. 2003. A grading scheme for the assessment of proliferative lesions of the mouse prostate in the TRAMP model. Toxicol Pathol 31(1):31-8. [PubMed: 12597447]  [MGI Ref ID J:81938]

Suttie AW; Dinse GE; Nyska A; Moser GJ; Goldsworthy TL; Maronpot RR. 2005. An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse. Toxicol Pathol 33(3):386-97. [PubMed: 15805078]  [MGI Ref ID J:97938]

Takahashi S; Watanabe T; Okada M; Inoue K; Ueda T; Takada I; Watabe T; Yamamoto Y; Fukuda T; Nakamura T; Akimoto C; Fujimura T; Hoshino M; Imai Y; Metzger D; Miyazono K; Minami Y; Chambon P; Kitamura T; Matsumoto T; Kato S. 2011. Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. Proc Natl Acad Sci U S A 108(12):4938-43. [PubMed: 21383160]  [MGI Ref ID J:170092]

Tam NN; Nyska A; Maronpot RR; Kissling G; Lomnitski L; Suttie A; Bakshi S; Bergman M; Grossman S; Ho SM. 2006. Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants. Prostate 66(1):57-69. [PubMed: 16114064]  [MGI Ref ID J:107353]

Tani Y; Suttie A; Flake GP; Nyska A; Maronpot RR. 2005. Epithelial-stromal tumor of the seminal vesicles in the transgenic adenocarcinoma mouse prostate model. Vet Pathol 42(3):306-14. [PubMed: 15872376]  [MGI Ref ID J:101136]

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Thapa D; Meng P; Bedolla RG; Reddick RL; Kumar AP; Ghosh R. 2014. NQO1 suppresses NF-kappaB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis. Cancer Res 74(19):5644-55. [PubMed: 25125658]  [MGI Ref ID J:216700]

Thobe MN; Gray JK; Gurusamy D; Paluch AM; Wagh PK; Pathrose P; Lentsch AB; Waltz SE. 2011. The Ron receptor promotes prostate tumor growth in the TRAMP mouse model. Oncogene 30(50):4990-8. [PubMed: 21625214]  [MGI Ref ID J:178572]

Tien JC; Zhou S; Xu J. 2009. The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression. Int J Biol Sci 5(3):256-64. [PubMed: 19305643]  [MGI Ref ID J:161100]

Touma SE; Perner S; Rubin MA; Nanus DM; Gudas LJ. 2009. Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. Biochem Pharmacol 78(9):1127-38. [PubMed: 19549509]  [MGI Ref ID J:154337]

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Vyas AR; Hahm ER; Arlotti JA; Watkins S; Stolz DB; Desai D; Amin S; Singh SV. 2013. Chemoprevention of prostate cancer by d,l-sulforaphane is augmented by pharmacological inhibition of autophagy. Cancer Res 73(19):5985-95. [PubMed: 23921360]  [MGI Ref ID J:202523]

Wada S; Yoshimura K; Hipkiss EL; Harris TJ; Yen HR; Goldberg MV; Grosso JF; Getnet D; Demarzo AM; Netto GJ; Anders R; Pardoll DM; Drake CG. 2009. Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model. Cancer Res 69(10):4309-18. [PubMed: 19435909]  [MGI Ref ID J:148472]

Wadsworth TL; Worstell TR; Greenberg NM; Roselli CE. 2007. Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP). Prostate 67(6):661-73. [PubMed: 17342743]  [MGI Ref ID J:122650]

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Wang X; Colby JK; Yang P; Fischer SM; Newman RA; Klein RD. 2008. The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. Carcinogenesis 29(1):120-8. [PubMed: 17942462]  [MGI Ref ID J:131198]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryTo generate this F1 strain, TRAMP transgenic females (Stock No. 003135) are mated with FVB/NJ males (Stock No. 001800).
Mating SystemHemizygote x Inbred         (Female x Male)   04-APR-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $246.90Female or MaleHemizygous for Tg(TRAMP)8247Ng  
Price per Pair (US dollars $)Pair Genotype
$261.63C57BL/6-Tg(TRAMP)8247Ng/J (003135) x FVB/NJ (001800)  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $321.00Female or MaleHemizygous for Tg(TRAMP)8247Ng  
Price per Pair (US dollars $)Pair Genotype
$340.20C57BL/6-Tg(TRAMP)8247Ng/J (003135) x FVB/NJ (001800)  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   See control note: The genetic background control is (C57BL/6J x FVB/NJ)F1 hybrid mice (Stock No. 019019). This F1 is created by breeding C57BL/6J females (Stock No. 000664) with FVB/NJ males (Stock No. 001800).
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  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Notice to customers in Canada.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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General inquiries regarding Terms of Use

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.