Strain Name:

NOD.C3(B6)-Faslgld /LwnJ

Stock Number:


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Common Names: NOD.gld;    
Congenic NOD mice homozygous for the Faslgld mutation develop lymphadenopathy and systemic autoimmunity. It has been reported that this model displays an accelerated Lupus phenotype compared to the C57BL/6 congenic background. This model is useful for studying apoptosis of lymphocytes, particularly T cells, and Lupus.


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLtJ
Donor Strain B6Smn.C3-Faslgld/J
H2 Haplotypeg7
Generation Definitions
Donating Investigator Li Wen,   Yale School of Medicine

NOD congenic mice homozygous for the Faslgld spontaneous mutation are viable and fertile. The donating investigator reports that homozygous males and females develop lymphadenopathy and systemic autoimmunity beginning at 8 weeks of age, but do not develop diabetes. The Lupus phenotype is accelerated in this strain when compared to the B6-Faslgldstrain. This mutant strain may be useful in the studies of apoptosis of lymphocytes, particularly T cells, and in studies of Lupus.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized.. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

The spontaneous mutation Faslgld, Fas ligand (TNF superfamily, member 6); generalized lymphoproliferative disease found on Chr 1, was transferred from a C57BL/6 congenic background (Stock No. 001021) to the NOD/Caj (substrain maintained at Yale) background through 12 generations of backcrossing prior to making homozygous for the mutation. In 2008, the T1DR received this strain at N12F20.

Control Information

   001976 NOD/ShiLtJ
  Considerations for Choosing Controls

Related Strains

Strains carrying   Faslgld allele
001021   B6Smn.C3-Faslgld/J
000784   C3H/HeJ-Faslgld/J
002932   CPt.C3-Faslgld/J
View Strains carrying   Faslgld     (3 strains)

Strains carrying other alleles of Fasl
014547   FVB/N-Tg(tetO-Fasl)BDepa/J
003499   NOD-Tg(Ins2-Fasl)24Ach/J
View Strains carrying other alleles of Fasl     (2 strains)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Autoimmune Lymphoproliferative Syndrome; ALPS   (FASLG)
Lung Cancer   (FASLG)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Apoptosis Research
Extracellular Modulators

Cancer Research
Genes Regulating Growth and Proliferation

Cell Biology Research
Signal Transduction

Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains
      NOD/ShiLtJ Non-MHC Congenics

Immunology, Inflammation and Autoimmunity Research
      lupus erythematosus

Faslgld related

Apoptosis Research
Extracellular Modulators

Cancer Research
Genes Regulating Growth and Proliferation

Cell Biology Research
Signal Transduction

Hematological Research

Immunology, Inflammation and Autoimmunity Research
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Faslgld
Allele Name generalized lymphoproliferative disease
Allele Type Spontaneous
Common Name(s) CD95-; FasL-; Tnfsf6gld; gld;
Strain of OriginC3H/HeJ
Gene Symbol and Name Fasl, Fas ligand (TNF superfamily, member 6)
Chromosome 1
Gene Common Name(s) ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; Fas antigen ligand; Fas-L; TNFSF6; Tnfsf6; generalized lymphoproliferative disease; gld; tumor necrosis factor (ligand) superfamily, member 6;
Molecular Note A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 in the extracellular region of the encoded protein. [MGI Ref ID J:17445]


Genotyping Information

Genotyping Protocols

Faslgld, Restriction Enzyme Digest

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Faslgld related

Akiyama K; Chen C; Wang D; Xu X; Qu C; Yamaza T; Cai T; Chen W; Sun L; Shi S. 2012. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10(5):544-55. [PubMed: 22542159]  [MGI Ref ID J:185809]

Alard P; Clark SL; Kosiewicz MM. 2004. Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta. Eur J Immunol 34(4):1021-30. [PubMed: 15048712]  [MGI Ref ID J:115475]

Alenzi FQ; Marley SB; Lewis JL; Chandrashekran A; Warrens AN; Goldman JM; Gordon MY. 2002. A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics. Exp Hematol 30(12):1428-35. [PubMed: 12482505]  [MGI Ref ID J:118008]

Alexander CE; Kaye PM; Engwerda CR. 2001. CD95 is required for the early control of parasite burden in the liver of Leishmania donovani-infected mice. Eur J Immunol 31(4):1199-210. [PubMed: 11298345]  [MGI Ref ID J:68808]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533]  [MGI Ref ID J:101533]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Aprahamian T; Bonegio R; Rizzo J; Perlman H; Lefer DJ; Rifkin IR; Walsh K. 2006. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol 177(5):3028-34. [PubMed: 16920939]  [MGI Ref ID J:139547]

Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease. J Exp Med 199(8):1121-31. [PubMed: 15096538]  [MGI Ref ID J:91058]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Bachmann R; Eugster HP; Frei K; Fontana A; Lassmann H. 1999. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. Am J Pathol 154(5):1417-22. [PubMed: 10329594]  [MGI Ref ID J:114241]

Baker MB; Altman NH; Podack ER; Levy RB. 1996. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J Exp Med 183(6):2645-56. [PubMed: 8676085]  [MGI Ref ID J:33612]

Balkow S; Kersten A; Tran TT; Stehle T; Grosse P; Museteanu C; Utermohlen O; Pircher H; von Weizsacker F; Wallich R; Mullbacher A; Simon MM. 2001. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol 75(18):8781-91. [PubMed: 11507223]  [MGI Ref ID J:71217]

Bangale Y; Karle S; Planque S; Zhou YX; Taguchi H; Nishiyama Y; Li L; Kalaga R; Paul S. 2003. VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease. FASEB J 17(6):628-35. [PubMed: 12665475]  [MGI Ref ID J:82662]

Barreiro R; Luker G; Herndon J; Ferguson TA. 2004. Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10. J Immunol 173(3):1519-25. [PubMed: 15265879]  [MGI Ref ID J:92022]

Beamer CA; Holian A. 2007. Antigen-presenting cell population dynamics during murine silicosis. Am J Respir Cell Mol Biol 37(6):729-38. [PubMed: 17641296]  [MGI Ref ID J:141645]

Bhandoola A; Dolnick B; Fayad N; Nussenzweig A; Singer A. 2000. Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med 192(6):891-7. [PubMed: 10993919]  [MGI Ref ID J:112013]

Bhandoola A; Yui K; Siegel RM; Zerva L; Greene MI. 1994. Gld and lpr mice: single gene mutant models for failed self tolerance. Int Rev Immunol 11(3):231-44. [PubMed: 7930847]  [MGI Ref ID J:21989]

Bitsaktsis C; Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J Immunol 177(7):4644-51. [PubMed: 16982903]  [MGI Ref ID J:139316]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Booker JK; Reap EA; Cohen PL. 1998. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. J Immunol 161(9):4536-41. [PubMed: 9794379]  [MGI Ref ID J:112150]

Borges VM; Falcao H; Leite-Junior JH; Alvim L; Teixeira GP; Russo M; Nobrega AF; Lopes MF; Rocco PM; Davidson WF; Linden R; Yagita H; Zin WA; DosReis GA. 2001. Fas ligand triggers pulmonary silicosis. J Exp Med 194(2):155-64. [PubMed: 11457890]  [MGI Ref ID J:118034]

Bossaller L; Rathinam VA; Bonegio R; Chiang PI; Busto P; Wespiser AR; Caffrey DR; Li QZ; Mohan C; Fitzgerald KA; Latz E; Marshak-Rothstein A. 2013. Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol 191(5):2104-14. [PubMed: 23918976]  [MGI Ref ID J:205801]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149]  [MGI Ref ID J:144702]

Cai Z; Yang F; Yu L; Yu Z; Jiang L; Wang Q; Yang Y; Wang L; Cao X; Wang J. 2012. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol 188(12):5954-61. [PubMed: 22573809]  [MGI Ref ID J:188880]

Camacho IA; Singh N; Hegde VL; Nagarkatti M; Nagarkatti PS. 2005. Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells. J Immunol 175(1):90-103. [PubMed: 15972635]  [MGI Ref ID J:100624]

Capitini CM; Nasholm NM; Duncan BB; Guimond M; Fry TJ. 2013. Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis. J Immunol 190(3):1351-9. [PubMed: 23275602]  [MGI Ref ID J:193034]

Chakour R; Guler R; Bugnon M; Allenbach C; Garcia I; Mauel J; Louis J; Tacchini-Cottier F. 2003. Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal. Infect Immun 71(9):5287-95. [PubMed: 12933876]  [MGI Ref ID J:85214]

Chang E; Galle L; Maggs D; Estes DM; Mitchell WJ. 2000. Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice J Virol 74(24):11832-40. [PubMed: 11090183]  [MGI Ref ID J:65895]

Chattopadhyay G; Khan AQ; Sen G; Colino J; DuBois W; Rubtsov A; Torres RM; Potter M; Snapper CM. 2007. Transgenic expression of Bcl-xL or Bcl-2 by murine B cells enhances the in vivo antipolysaccharide, but not antiprotein, response to intact Streptococcus pneumoniae. J Immunol 179(11):7523-34. [PubMed: 18025197]  [MGI Ref ID J:154811]

Cheng LE; Chan FK; Cado D; Winoto A. 1997. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 16(8):1865-75. [PubMed: 9155013]  [MGI Ref ID J:40025]

Chrobak P; Gress RE. 2001. Veto activity of activated bone marrow does not require perforin and Fas ligand. Cell Immunol 208(2):80-7. [PubMed: 11333140]  [MGI Ref ID J:127838]

Chu JL; Ramos P; Rosendorff A; Nikolic-Zugic J; Lacy E; Matsuzawa A; Elkon KB. 1995. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J Exp Med 181(1):393-8. [PubMed: 7528774]  [MGI Ref ID J:22200]

Chung CS; Wang W; Chaudry IH; Ayala A. 2001. Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated. Am J Physiol Gastrointest Liver Physiol 280(5):G812-8. [PubMed: 11292588]  [MGI Ref ID J:69305]

Coerver KA; Woodruff TK; Finegold MJ; Mather J; Bradley A; Matzuk MM. 1996. Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice. Mol Endocrinol 10(5):534-43. [PubMed: 8732684]  [MGI Ref ID J:112001]

Cohen PL; Eisenberg RA. 1991. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol 9:243-69. [PubMed: 1910678]  [MGI Ref ID J:27579]

Cohen PL; Eisenberg RA. 1992. The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane [published erratum appears in Immunol Today 1993 Feb;14(2):97] Immunol Today 13(11):427-8. [PubMed: 1282318]  [MGI Ref ID J:3363]

Colino J; Snapper CM. 2003. Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J Immunol 171(5):2354-65. [PubMed: 12928382]  [MGI Ref ID J:121185]

Conceicao-Silva F; Hahne M; Schroter M; Louis J; Tschopp J. 1998. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity Eur J Immunol 28(1):237-45. [PubMed: 9485203]  [MGI Ref ID J:45903]

Cone RE; Li X; Sharafieh R; O'Rourke J; Vella AT. 2007. The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120(1):112-9. [PubMed: 17052246]  [MGI Ref ID J:122316]

Couillard M; Guillaume R; Tanji N; D'Agati V; Trudel M. 2002. c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction. Cancer Res 62(8):2210-4. [PubMed: 11956070]  [MGI Ref ID J:134937]

Crawford HC; Scoggins CR; Washington MK; Matrisian LM; Leach SD. 2002. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest 109(11):1437-44. [PubMed: 12045257]  [MGI Ref ID J:76811]

Cretney E; Uldrich AP; McNab FW; Godfrey DI; Smyth MJ. 2008. No requirement for TRAIL in intrathymic negative selection. Int Immunol 20(2):267-76. [PubMed: 18192669]  [MGI Ref ID J:131293]

Cullen CM; Bonventre PF; Heeg H; Bluethmann H; Mountz JD; Edwards CK 3rd. 1995. A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice. Pathobiology 63(6):293-304. [PubMed: 8738468]  [MGI Ref ID J:33149]

Dakhova O; O'Day D; Kinet N; Yucer N; Wiese M; Shetty G; Ducy P. 2009. Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production. Endocrinology 150(1):404-12. [PubMed: 18818293]  [MGI Ref ID J:146994]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davidson WF; Dumont FJ; Bedigian HG; Fowlkes BJ; Morse HC 3rd. 1986. Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. J Immunol 136(11):4075-84. [PubMed: 3009614]  [MGI Ref ID J:8267]

Davidson WF; Giese T; Fredrickson TN. 1998. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. J Exp Med 187(11):1825-38. [PubMed: 9607923]  [MGI Ref ID J:49221]

Davidson WF; Holmes KL; Roths JB; Morse HC 3rd. 1985. Immunologic abnormalities of mice bearing the gld mutation suggest a common pathway for murine nonmalignant lymphoproliferative disorders with autoimmunity. Proc Natl Acad Sci U S A 82(4):1219-23. [PubMed: 3856256]  [MGI Ref ID J:12002]

Davies MH; Eubanks JP; Powers MR. 2003. Increased retinal neovascularization in Fas ligand-deficient mice. Invest Ophthalmol Vis Sci 44(7):3202-10. [PubMed: 12824272]  [MGI Ref ID J:117984]

Desbarats J; Newell MK. 2000. Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6(8):920-3. [PubMed: 10932231]  [MGI Ref ID J:118048]

Dittel BN; Merchant RM; Janeway CA Jr. 1999. Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 162(11):6392-400. [PubMed: 10352252]  [MGI Ref ID J:110922]

Dix RD; Podack ER; Cousins SW. 2003. Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis. J Virol 77(6):3402-8. [PubMed: 12610115]  [MGI Ref ID J:82226]

Dudani R; Russell M; van Faassen H; Krishnan L; Sad S. 2008. Mutation in the Fas Pathway Impairs CD8+ T Cell Memory. J Immunol 180(5):2933-41. [PubMed: 18292515]  [MGI Ref ID J:131560]

Edinger M; Hoffmann P; Ermann J; Drago K; Fathman CG; Strober S; Negrin RS. 2003. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9(9):1144-50. [PubMed: 12925844]  [MGI Ref ID J:126172]

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Embree-Ku M; Boekelheide K. 2002. Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction. Exp Biol Med (Maywood) 227(7):545-53. [PubMed: 12094020]  [MGI Ref ID J:103281]

Embree-Ku M; Boekelheide K. 2002. FasL deficiency enhances the development of tumors in p53+/- mice. Toxicol Pathol 30(6):705-13. [PubMed: 12512872]  [MGI Ref ID J:81060]

Engelbert M; Gilmore MS. 2005. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Invest Ophthalmol Vis Sci 46(7):2479-86. [PubMed: 15980239]  [MGI Ref ID J:136745]

Ettinger R; Wang JK; Bossu P; Papas K; Sidman CL; Abbas AK; Marshak-Rothstein A. 1994. Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect. J Immunol 152(4):1557-68. [PubMed: 8120369]  [MGI Ref ID J:16936]

Fan H; Patel VA; Longacre A; Levine JS. 2006. Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity. J Leukoc Biol 79(1):155-65. [PubMed: 16244106]  [MGI Ref ID J:104741]

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Fields ML; Nish SA; Hondowicz BD; Metzgar MH; Wharton GN; Caton AJ; Erikson J. 2005. The influence of effector T cells and Fas ligand on lupus-associated B cells. J Immunol 175(1):104-11. [PubMed: 15972636]  [MGI Ref ID J:100620]

Fields ML; Sokol CL; Eaton-Bassiri A; Seo Sj; Madaio MP; Erikson J. 2001. Fas/fas ligand deficiency results in altered localization of anti-double-stranded dna b cells and dendritic cells. J Immunol 167(4):2370-8. [PubMed: 11490027]  [MGI Ref ID J:70822]

Fingleton B; Carter KJ; Matrisian LM. 2007. Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model. Cancer Res 67(10):4800-6. [PubMed: 17510409]  [MGI Ref ID J:121728]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Ford MS; Young KJ; Zhang Z; Ohashi PS; Zhang L. 2002. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J Exp Med 196(2):261-7. [PubMed: 12119351]  [MGI Ref ID J:120698]

Fraszczak J; Trad M; Janikashvili N; Cathelin D; Lakomy D; Granci V; Morizot A; Audia S; Micheau O; Lagrost L; Katsanis E; Solary E; Larmonier N; Bonnotte B. 2010. Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells. J Immunol 184(4):1876-84. [PubMed: 20089706]  [MGI Ref ID J:159469]

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Fujikura D; Chiba S; Muramatsu D; Kazumata M; Nakayama Y; Kawai T; Akira S; Kida H; Miyazaki T. 2013. Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. PLoS One 8(2):e55321. [PubMed: 23408968]  [MGI Ref ID J:197206]

Fullerton AM; Roth RA; Ganey PE. 2013. 2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury. Toxicol Appl Pharmacol 266(2):317-27. [PubMed: 23164664]  [MGI Ref ID J:193201]

Giese T; Davidson WF. 1994. Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production. J Immunol 152(4):2000-10. [PubMed: 8120404]  [MGI Ref ID J:17479]

Giese T; Davidson WF. 1992. Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr. J Immunol 149(9):3097-106. [PubMed: 1383337]  [MGI Ref ID J:3035]

Giese T; Davidson WF. 1995. The accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells. Int Immunol 7(8):1213-23. [PubMed: 7495728]  [MGI Ref ID J:28207]

Graubert TA; DiPersio JF; Russell JH; Ley TJ. 1997. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100(4):904-11. [PubMed: 9259590]  [MGI Ref ID J:42355]

Gregory MS; Hackett CG; Abernathy EF; Lee KS; Saff RR; Hohlbaum AM; Moody KS; Hobson MW; Jones A; Kolovou P; Karray S; Giani A; John SW; Chen DF; Marshak-Rothstein A; Ksander BR. 2011. Opposing roles for membrane bound and soluble fas ligand in glaucoma-associated retinal ganglion cell death. PLoS One 6(3):e17659. [PubMed: 21479271]  [MGI Ref ID J:171440]

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Suzuki A; Tsutomi Y; Shimizu M; Matsuzawa A. 1999. Another cell death induction system: TNF-alpha acts as a ligand for Fas in vaginal cells. Cell Death Differ 6(7):638-43. [PubMed: 10453074]  [MGI Ref ID J:114219]

Swann JB; Vesely MD; Silva A; Sharkey J; Akira S; Schreiber RD; Smyth MJ. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc Natl Acad Sci U S A 105(2):652-6. [PubMed: 18178624]  [MGI Ref ID J:131026]

Taguchi N; Hashimoto Y; Naiki M; Farr AG; Boyd RL; Ansari AA; Shultz LD; Kotzin BL; Dorshkind K; Ikehara S; Gershwin ME. 1999. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun 13(4):393-404. [PubMed: 10585755]  [MGI Ref ID J:59174]

Takahashi T; Tanaka M; Brannan CI; Jenkins NA; Copeland NG; Suda T; Nagata S. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76(6):969-76. [PubMed: 7511063]  [MGI Ref ID J:17445]

Takaki R; Hayakawa Y; Nelson A; Sivakumar PV; Hughes S; Smyth MJ; Lanier LL. 2005. IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J Immunol 175(4):2167-73. [PubMed: 16081783]  [MGI Ref ID J:108483]

Takeda K; Hayakawa Y; Van Kaer L; Matsuda H; Yagita H; Okumura K. 2000. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc Natl Acad Sci U S A 97(10):5498-503. [PubMed: 10792025]  [MGI Ref ID J:62215]

Takeoka Y; Taguchi N; Shultz L; Boyd RL; Naiki M; Ansari AA; Gershwin ME. 1999. Apoptosis and the thymic microenvironment in murine lupus. J Autoimmun 13(3):325-34. [PubMed: 10550220]  [MGI Ref ID J:58407]

Takeoka Y; Yoshida SH; Van de Water J; Boyd R; Suehiro S; Ansari AA; Gershwin ME. 1995. Thymic microenvironmental abnormalities in MRL/MP-lpr/lpr, BXSB/MpJ Yaa and C3H HeJ-gld/gld mice. J Autoimmun 8(2):145-61. [PubMed: 7612145]  [MGI Ref ID J:24324]

Tamayo E; Postigo J; Del Giudice G; Rappuoli R; Benito A; Yagita H; Merino R; Merino J. 2009. Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin. Eur J Immunol 39(2):439-46. [PubMed: 19180465]  [MGI Ref ID J:144472]

Tamura A; Katsumata M; Greene MI; Yui K. 1996. Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice. Cell Immunol 168(2):220-8. [PubMed: 8640868]  [MGI Ref ID J:31852]

Tamura A; Yui K. 1995. Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice. J Immunol 155(1):499-507. [PubMed: 7602121]  [MGI Ref ID J:26199]

Taniguchi Y; Ito MR; Mori S; Yonehara S; Nose M. 1996. Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis. Clin Exp Immunol 106(1):26-34. [PubMed: 8870694]  [MGI Ref ID J:35619]

Tarzi RM; Sharp PE; McDaid JP; Fossati-Jimack L; Herbert PE; Pusey CD; Cook HT; Warrens AN. 2012. Mice with defective Fas ligand are protected from crescentic glomerulonephritis. Kidney Int 81(2):170-8. [PubMed: 21918502]  [MGI Ref ID J:196501]

Tatituri RV; Watts GF; Bhowruth V; Barton N; Rothchild A; Hsu FF; Almeida CF; Cox LR; Eggeling L; Cardell S; Rossjohn J; Godfrey DI; Behar SM; Besra GS; Brenner MB; Brigl M. 2013. Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A 110(5):1827-32. [PubMed: 23307809]  [MGI Ref ID J:193701]

Teh CE; Daley SR; Enders A; Goodnow CC. 2010. T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A 107(33):14709-14. [PubMed: 20668237]  [MGI Ref ID J:163595]

Tong J; Clay BS; Ferreira CM; Bandukwala HS; Moore TV; Blaine KM; Williams JW; Hoffman LM; Hamann KJ; Shilling RA; Weinstock JV; Sperling AI. 2010. Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma. Am J Respir Cell Mol Biol 43(3):342-8. [PubMed: 19855087]  [MGI Ref ID J:175438]

Torrero MN; Xia X; Henk W; Yu S; Li S. 2006. Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression. Cancer Res 66(8):4461-7. [PubMed: 16618773]  [MGI Ref ID J:108303]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Tregoning JS; Wang BL; McDonald JU; Yamaguchi Y; Harker JA; Goritzka M; Johansson C; Bukreyev A; Collins PL; Openshaw PJ. 2013. Neonatal antibody responses are attenuated by interferon-gamma produced by NK and T cells during RSV infection. Proc Natl Acad Sci U S A 110(14):5576-81. [PubMed: 23509276]  [MGI Ref ID J:194232]

Tsutsui H; Kayagaki N; Kuida K; Nakano H; Hayashi N; Takeda K; Matsui K; Kashiwamura S; Hada T; Akira S; Yagita H; Okamura H; Nakanishi K. 1999. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 11(3):359-67. [PubMed: 10514014]  [MGI Ref ID J:57879]

Turner J; D'Souza CD; Pearl JE; Marietta P; Noel M; Frank AA; Appelberg R; Orme IM; Cooper AM. 2001. CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis. Am J Respir Cell Mol Biol 24(2):203-9. [PubMed: 11159055]  [MGI Ref ID J:114284]

Urbieta M; Barao I; Jones M; Jurecic R; Panoskaltsis-Mortari A; Blazar BR; Murphy WJ; Levy RB. 2010. Hematopoietic progenitor cell regulation by CD4+CD25+ T cells. Blood 115(23):4934-43. [PubMed: 20200356]  [MGI Ref ID J:161563]

Vacchio MS; Hodes RJ. 2005. Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy. J Immunol 174(8):4657-61. [PubMed: 15814689]  [MGI Ref ID J:98158]

Vallabhapurapu S; Ryseck RP; Malewicz M; Weih DS; Weih F. 2001. Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice. Eur J Immunol 31(9):2612-22. [PubMed: 11536159]  [MGI Ref ID J:71678]

Van Parijs L; Peterson DA; Abbas AK. 1998. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity 8(2):265-74. [PubMed: 9492007]  [MGI Ref ID J:110425]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Varanasi V; Avanesyan L; Schumann DM; Chervonsky AV. 2012. Cytotoxic mechanisms employed by mouse t cells to destroy pancreatic beta-cells. Diabetes 61(11):2862-70. [PubMed: 22773667]  [MGI Ref ID J:190161]

Velin D; Goettelfinger P; Froidevaux S; Loor F. 1993. gld and lpr hematopoietic cell transfers: common and different serological features of the C57BL/6 chimeras. Cell Immunol 148(2):331-45. [PubMed: 8098670]  [MGI Ref ID J:4761]

Vera Y; Erkkila K; Wang C; Nunez C; Kyttanen S; Lue Y; Dunkel L; Swerdloff RS; Sinha Hikim AP. 2006. Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation. Mol Endocrinol 20(7):1597-609. [PubMed: 16469770]  [MGI Ref ID J:110069]

Via CS; Nguyen P; Shustov A; Drappa J; Elkon KB. 1996. A major role for the Fas pathway in acute graft-versus-host disease. J Immunol 157(12):5387-93. [PubMed: 8955186]  [MGI Ref ID J:37623]

Wahlsten JL; Gitchell HL; Chan CC; Wiggert B; Caspi RR. 2000. Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis. J Immunol 165(10):5480-6. [PubMed: 11067900]  [MGI Ref ID J:119582]

Waldner H; Sobel RA; Howard E; Kuchroo VK. 1997. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J Immunol 159(7):3100-3. [PubMed: 9317104]  [MGI Ref ID J:43096]

Walk EL; McLaughlin S; Coad J; Weed SA. 2014. Use of high frequency ultrasound to monitor cervical lymph node alterations in mice. PLoS One 9(6):e100185. [PubMed: 24955984]  [MGI Ref ID J:216826]

Wallach-Dayan SB; Golan-Gerstl R; Breuer R. 2007. Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis. Proc Natl Acad Sci U S A 104(51):20460-5. [PubMed: 18077384]  [MGI Ref ID J:130580]

Wang X; Ria M; Kelmenson PM; Eriksson P; Higgins DC; Samnegard A; Petros C; Rollins J; Bennet AM; Wiman B; de Faire U; Wennberg C; Olsson PG; Ishii N; Sugamura K; Hamsten A; Forsman-Semb K; Lagercrantz J; Paigen B. 2005. Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. Nat Genet 37(4):365-72. [PubMed: 15750594]  [MGI Ref ID J:97460]

Wang X; Ryter SW; Dai C; Tang ZL; Watkins SC; Yin XM; Song R; Choi AM. 2003. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J Biol Chem 278(31):29184-91. [PubMed: 12754217]  [MGI Ref ID J:120650]

Weih F; Ryseck RP; Chen L; Bravo R. 1996. Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc Natl Acad Sci U S A 93(11):5533-8. [PubMed: 8643610]  [MGI Ref ID J:78762]

Weintraub JP; Cohen PL. 1999. Ectopic expression of B7-1 (CD80) on T lymphocytes in autoimmune lpr and gld mice. Clin Immunol 91(3):302-9. [PubMed: 10370375]  [MGI Ref ID J:55186]

Weintraub JP; Eisenberg RA; Cohen PL. 1997. Up-regulation of Fas and the costimulatory molecules B7-1 and B7-2 on peripheral lymphocytes in autoimmune B6/gld mice. J Immunol 159(8):4117-26. [PubMed: 9379003]  [MGI Ref ID J:43938]

Weintraub JP; Godfrey V; Wolthusen PA; Cheek RL; Eisenberg RA ; Cohen PL. 1998. Immunological and pathological consequences of mutations in both Fas and Fas ligand. Cell Immunol 186(1):8-17. [PubMed: 9637760]  [MGI Ref ID J:48251]

Weng D; Marty-Roix R; Ganesan S; Proulx MK; Vladimer GI; Kaiser WJ; Mocarski ES; Pouliot K; Chan FK; Kelliher MA; Harris PA; Bertin J; Gough PJ; Shayakhmetov DM; Goguen JD; Fitzgerald KA; Silverman N; Lien E. 2014. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A 111(20):7391-6. [PubMed: 24799678]  [MGI Ref ID J:211055]

Wenkel H; Streilein JW. 2000. Evidence that retinal pigment epithelium functions as an immune-privileged tissue. Invest Ophthalmol Vis Sci 41(11):3467-73. [PubMed: 11006240]  [MGI Ref ID J:115595]

Wesche-Soldato DE; Chung CS; Gregory SH; Salazar-Mather TP; Ayala CA; Ayala A. 2007. CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL. Am J Pathol 171(1):87-96. [PubMed: 17591956]  [MGI Ref ID J:122836]

Wiede F; Roomberg A; Cretney E; Lechner A; Fromm P; Wren L; Smyth MJ; Korner H. 2009. Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice. J Leukoc Biol 85(1):108-16. [PubMed: 18948547]  [MGI Ref ID J:144623]

Wiede F; Vana K; Sedger LM; Lechner A; Korner H. 2007. TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder. Eur J Immunol 37(2):351-7. [PubMed: 17236235]  [MGI Ref ID J:117875]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wildbaum G; Zohar Y; Karin N. 2010. Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17. Am J Pathol 176(6):2764-75. [PubMed: 20382706]  [MGI Ref ID J:161337]

Wingender G; Krebs P; Beutler B; Kronenberg M. 2010. Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency. J Immunol 185(5):2721-9. [PubMed: 20660713]  [MGI Ref ID J:163266]

Woodworth JS; Wu Y; Behar SM. 2008. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol 181(12):8595-603. [PubMed: 19050279]  [MGI Ref ID J:142057]

Xiao S; Zhang X; Mann KK; Jodo S; Li L; Jarjour WN; Marshak-Rothstein A; Sherr DH; Ju ST. 2004. Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int Immunol 16(5):759-66. [PubMed: 15096479]  [MGI Ref ID J:89570]

Xiao Z; Mohamood AS; Uddin S; Gutfreund R; Nakata C; Marshall A; Kimura H; Caturegli P; Womer KL; Huang Y; Jie C; Chakravarti S; Schneck JP; Yagita H; Hamad AR. 2011. Inhibition of Fas Ligand in NOD Mice Unmasks a Protective Role for IL-10 against Insulitis Development. Am J Pathol 179(2):725-32. [PubMed: 21718680]  [MGI Ref ID J:174384]

Xu X; Yi H; Guo Z; Qian C; Xia S; Yao Y; Cao X. 2012. Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-gamma and nitric oxide. J Immunol 188(3):1168-77. [PubMed: 22205032]  [MGI Ref ID J:180753]

Yano T; Ito K; Fukamachi H; Chi XZ; Wee HJ; Inoue K; Ida H; Bouillet P; Strasser A; Bae SC; Ito Y. 2006. The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol 26(12):4474-88. [PubMed: 16738314]  [MGI Ref ID J:109611]

Yao Y; Han W; Liang J; Ji J; Wang J; Cantor H; Lu L. 2013. Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8(+) regulatory cells. Eur J Immunol 43(1):125-36. [PubMed: 23002042]  [MGI Ref ID J:191109]

Yasuda T; Kuwabara T; Nakano H; Aritomi K; Onodera T; Lipp M; Takahama Y; Kakiuchi T. 2007. Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109(2):449-56. [PubMed: 16973962]  [MGI Ref ID J:144008]

Yasutomo K; Maeda K; Nagata S; Nagasawa H; Okada K; Good RA; Kuroda Y; Himeno K. 1994. Defective T cells from gld mice play a pivotal role in development of Thy-1.2+B220+ cells and autoimmunity. J Immunol 153(12):5855-64. [PubMed: 7527451]  [MGI Ref ID J:22256]

Zangi L; Klionsky YZ; Yarimi L; Bachar-Lustig E; Eidelstein Y; Shezen E; Hagin D; Ito Y; Takai T; Reich-Zeliger S; Lask A; Milstein O; Jung S; Shinder V; Reisner Y. 2012. Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood 120(8):1647-57. [PubMed: 22776817]  [MGI Ref ID J:189175]

Zeiser R; Youssef S; Baker J; Kambham N; Steinman L; Negrin RS. 2007. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood 110(13):4588-98. [PubMed: 17827390]  [MGI Ref ID J:149097]

Zelinskyy G; Balkow S; Schimmer S; Schepers K; Simon MM; Dittmer U. 2004. Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection. Virology 330(2):365-74. [PubMed: 15567431]  [MGI Ref ID J:95485]

Zhang B; Zhang Y; Niu L; Vella AT; Mittler RS. 2010. Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death. J Immunol 184(9):4770-8. [PubMed: 20351189]  [MGI Ref ID J:160463]

Zhang HG; Fleck M; Kern ER; Liu D; Wang Y; Hsu HC; Yang P; Wang Z; Curiel DT; Zhou T; Mountz JD. 2000. Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice. J Clin Invest 105(6):813-21. [PubMed: 10727450]  [MGI Ref ID J:61112]

Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. [PubMed: 15583018]  [MGI Ref ID J:94696]

Zhang Y; Xu G; Zhang L; Roberts AI; Shi Y. 2008. Th17 cells undergo fas-mediated activation-induced cell death independent of IFN-gamma. J Immunol 181(1):190-6. [PubMed: 18566384]  [MGI Ref ID J:137178]

Zhao DM; Thornton AM; DiPaolo RJ; Shevach EM. 2006. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107(10):3925-32. [PubMed: 16418326]  [MGI Ref ID J:132735]

Zhou Z; Wu M; Barrett RP; McClellan SA; Zhang Y; Hazlett LD. 2010. Role of the Fas pathway in Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci 51(5):2537-47. [PubMed: 20019368]  [MGI Ref ID J:164107]

Zuliani C; Kleber S; Klussmann S; Wenger T; Kenzelmann M; Schreglmann N; Martinez A; del Rio JA; Soriano E; Vodrazka P; Kuner R; Groene HJ; Herr I; Krammer PH; Martin-Villalba A. 2006. Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell Death Differ 13(1):31-40. [PubMed: 16003386]  [MGI Ref ID J:121029]

de Oliveira GM; Diniz RL; Batista W; Batista MM; Bani Correa C; de Araujo-Jorge TC; Henriques-Pons A. 2007. Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection. Am J Pathol 171(1):79-86. [PubMed: 17591955]  [MGI Ref ID J:122837]

van den Brink MR; Moore E; Horndasch KJ; Crawford JM; Murphy GF; Burakoff SJ. 2000. Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease. Transplantation 70(1):184-91. [PubMed: 10919598]  [MGI Ref ID J:63433]

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Cryopreserved Mice - Ready for Recovery

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Cryorecovery* $2225.00
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At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2892.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.