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Strain Common Names	NOD.gld;
Genes & Alleles	Fasl;   Faslgld;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain B6Smn.C3-Faslgld/J Donating Investigator Li Wen,   Yale School of Medicine H2 Haplotype g7 Generation N12+N1F1 (14-AUG-08)

Strain Description
Mice homozygous for the Fasl^gld spontaneous mutation are viable and fertile. Homozygous males and females develop lymphadenopathy and systemic autoimmunity beginning at 8 weeks of age, but do not develop diabetes. The Lupus phenotype is accelerated in this strain when compared to the B6-Fasl^gldstrain. This mutant strain may be useful in the studies of apoptosis of lymphocytes, particularly T cells, and in studies of Lupus.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized.. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Strain Development
The spontaneous mutation Fasl^gld, Fas ligand (TNF superfamily, member 6); generalized lymphoproliferative disease found on Chr 1, was transferred from a C57BL/6 congenic background (Stock No. 001021) to the NOD/CaJ background through 12 generations of backcrossing prior to making homozygous for the mutation. In 2008, the T1DR received this strain at N12F20.

Gene & Allele Details

Allele Symbol		Faslgld
Allele Name		generalized lymphoproliferative disease
Common Name(s)		CD95-; FasL-; Tnfsf6gld; gld;
Strain of Origin		C3H/HeJ
Gene Symbol and Name		Fasl, Fas ligand (TNF superfamily, member 6)
Chromosome		1
Gene Common Name(s)		APT1LG1; CD178; CD95L; Fas antigen ligand; Fas-L; Faslg; TNFSF6; Tnfsf6; generalized lymphoproliferative disease; gld; tumor necrosis factor (ligand) superfamily, member 6;
Molecular Note		A T-to-C transition point mutation near the 3' end of the coding sequence causes a replacement of a highly conserved phenylalanine with a leucine at position 273 in the extracellular region of the encoded protein. [MGI Ref ID J:17445]

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls

Genotyping Protocols

Fasl^gld

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying   Fasl^gld allele

001021	B6Smn.C3-Faslgld/J
000784	C3H/HeJ-Faslgld/J
002932	CPt.C3-Faslgld/J

View Strains carrying   Fasl^gld     (3 strains)

Strains carrying other alleles of Fasl

003499

NOD-Tg(Ins2-Fasl)24Ach

View Strains carrying other alleles of Fasl     (1 strain)

Additional Web Information

Congenic Nomenclature

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Apoptosis Research
Extracellular Modulators

Cancer Research
Genes Regulating Growth and Proliferation

Cell Biology Research
Signal Transduction

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) (resistant)
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)

Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)

Mouse/Human Gene Homologs
systemic lupus erythematosus

Fasl^gld related

Apoptosis Research
Extracellular Modulators

Cancer Research
Genes Regulating Growth and Proliferation

Cell Biology Research
Signal Transduction

Hematological Research

Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)

Mouse/Human Gene Homologs
systemic lupus erythematosus

References

Additional References

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Price and Supply Information

Strain Name:	NOD.C3(B6)-Faslgld /LwnJ
Stock Number:	008223

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Type 1 Diabetes Repository collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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