Strain Name:

C57BL/6J-Tg(Th-SNCA)5Eric/J

Stock Number:

008245

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
Common Names: B6J(hw5);    
These hwα-SYN-5 transgenic mice may be useful for studying Parkinson's disease, Lewy bodies, neurodegeneration, and synaptic plasticity in conjunction with Stock No. 008239.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationN6+N1F2pN1
Generation Definitions
 
Donating Investigator Eric Richfield,   Rutger's University (EOHSI/UMDNJ)

Description
These hwα-SYN-5 mice express wildtype human alpha-synuclein (hα-SYN) under the control of the rat tyrosine hydroxylase promoter. Expression of hα-SYN is detected in cell bodies, axons, and terminals of the nigrostriatal system (mRNA expression in midbrain, eye, and adrenal gland, with high levels of protein expression in the cell bodies of dopaminergic neurons in the midbrain and striatum). Hemizygous mice exhibit several Parkinson's disease-related characteristics including increased density of the dopamine transporter, impairments of the ubiquitin-proteasome system, and age-related progressive loss of locomotor activity and substantia nigra pars compacta dopaminergic neurons. The Parkinson's disease-related phenotype of these hwα-SYN-5 mice is intermediate between that of the C57BL/6J wild-type controls and the severely affected hm2α-SYN-39 strain (see Stock No. 008239). As such, these hwα-SYN-5 transgenic mice may be useful for studying Parkinson's disease, Lewy bodies, neurodegeneration, and synaptic plasticity in conjunction with Stock No. 008239.

Development
A 469 bp human alpha-synuclein cDNA was placed downstream of a 9 kb rat tyrosine hydroxylase promoter (and splice donor/intron/splice acceptor) and upstream of a polyA signal. This transgene was injected into C57BL/6 oocytes. Mice from founder line 5 (hwα-SYN-5) were found to have the highest levels of transgene mRNA expression in midbrain. These hwα-SYN-5 mice were maintained by breeding transgenic mice with wild-type or C57BL/6J for many generations prior to sending to The Jackson Laboratory Repository. Upon arrival, mice were bred to C57BL/6J (Stock No. 000664) for at least one generation to establish the colony.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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Strains carrying other alleles of Th
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Additional Web Information

Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Dementia, Lewy Body; DLB   (SNCA)
Parkinson Disease 1, Autosomal Dominant; PARK1   (SNCA)
Parkinson Disease 4, Autosomal Dominant; PARK4   (SNCA)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric

        involves: C57BL/6
  • immune system phenotype
  • abnormal microglial cell physiology
    • at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice   (MGI Ref ID J:140907)
    • however, the total number of microglial cells is normal   (MGI Ref ID J:140907)
  • nervous system phenotype
  • abnormal microglial cell physiology
    • at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice   (MGI Ref ID J:140907)
    • however, the total number of microglial cells is normal   (MGI Ref ID J:140907)
  • hematopoietic system phenotype
  • abnormal microglial cell physiology
    • at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice   (MGI Ref ID J:140907)
    • however, the total number of microglial cells is normal   (MGI Ref ID J:140907)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Ataxia (Movement) Defects
Neurodegeneration
Neurotransmitter Receptor and Synaptic Vesicle Defects
Parkinson's Disease
      synuclein mutants

Research Tools
Neurobiology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Th-SNCA)5Eric
Allele Name transgene insertion 5, Eric K Richfield
Allele Type Transgenic (random, expressed)
Common Name(s) THsynWT; Tg(Th-SNCA)5Fed; hwalpha-SYN-5;
Mutation Made By Eric Richfield,   Rutger's University (EOHSI/UMDNJ)
Strain of OriginC57BL/6
Expressed Gene SNCA, synuclein, alpha (non A4 component of amyloid precursor), human
Promoter Th, tyrosine hydroxylase, rat
General Note Line 88 was also generated using this wild-type construct.

Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:140907)

Molecular Note The transgene contains a 9 kb rat tyrosine hydroxylase promoter, a splice donor/intron/splice acceptor, a poly(A) site from the human growth hormone gene, and a wild-type human alpha synuclein cDNA. RT-PCR detected transgene expression in midbrain, eye, and adrenal gland. Real time quantitative RT-PCR as well as in situ hybridization histochemistry detected high levels of transgene expression in the midbrain. Catecholaminergic nuclei in the brain of transgenic mice expressed both human mRNA and human protein. These mice express high levels of the human protein in the cell bodies of dopaminergic neurons in the midbrain and its main projection region, the striatum, dopaminergic dendrites, and nigrostriatal axons and terminals. [MGI Ref ID J:76482]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Th-SNCA), High Resolution Melting
Tg(Th-SNCA), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Richfield EK; Thiruchelvam MJ; Cory-Slechta DA; Wuertzer C; Gainetdinov RR; Caron MG; Di Monte DA; Federoff HJ. 2002. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol 175(1):35-48. [PubMed: 12009758]  [MGI Ref ID J:76482]

Additional References

Tg(Th-SNCA)5Eric related

Chen L; Thiruchelvam MJ; Madura K; Richfield EK. 2006. Proteasome dysfunction in aged human alpha-synuclein transgenic mice. Neurobiol Dis 23(1):120-6. [PubMed: 16713278]  [MGI Ref ID J:111193]

Miller RM; Kiser GL; Kaysser-Kranich T; Casaceli C; Colla E; Lee MK; Palaniappan C; Federoff HJ. 2007. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol 204(1):421-32. [PubMed: 17254569]  [MGI Ref ID J:119487]

Peneder TM; Scholze P; Berger ML; Reither H; Heinze G; Bertl J; Bauer J; Richfield EK; Hornykiewicz O; Pifl C. 2011. Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice. Neuroscience 180:280-92. [PubMed: 21333719]  [MGI Ref ID J:173693]

Prasad K; Tarasewicz E; Strickland PA; O'Neill M; Mitchell SN; Merchant K; Tep S; Hilton K; Datwani A; Buttini M; Mueller-Steiner S; Richfield EK. 2011. Biochemical and morphological consequences of human alpha-synuclein expression in a mouse alpha-synuclein null background. Eur J Neurosci 33(4):642-56. [PubMed: 21272100]  [MGI Ref ID J:174647]

Su X; Maguire-Zeiss KA; Giuliano R; Prifti L; Venkatesh K; Federoff HJ. 2008. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging 29(11):1690-701. [PubMed: 17537546]  [MGI Ref ID J:140907]

Thiruchelvam MJ; Powers JM; Cory-Slechta DA; Richfield EK. 2004. Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice. Eur J Neurosci 19(4):845-54. [PubMed: 15009131]  [MGI Ref ID J:96494]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygotes are bred to wildtype siblings or to inbred C57BL/6J mice.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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