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Strain Name:

C57BL/6J-Clcn1adr-mto9J/J

Stock Number:

008253

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Clcn1;   Clcn1adr-mto9J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Chemically Induced Mutation
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Coisogenic
Specieslaboratory mouse
Generation+N1F3 (03-JUN-08)

Strain Description
This allele of myotonia is slightly milder in severity than the original adr-mto mutation.

Strain Development
The myotonia 9 Jackson mutation was identified after ENU mutagenesis of C57BL/6J males as part of the Heart, Lung, Blood Mutagenesis program at The Jackson Laboratory. It has been maintained on this inbred background.

Mammalian Phenotype Terms assigned by genotype

Clcn1adr-mto9J/Clcn1adr-mto9J

        C57BL/6J-Clcn1adr-mto9J/J
  • muscle phenotype
  • impaired muscle relaxation (MGI Ref ID J:134519)
    • as early as 2 weeks of age homozygotes stiffen their rear legs when touched
  • behavior/neurological phenotype
  • hindlimb paralysis (MGI Ref ID J:134519)
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:134519)
    • smaller and thinner than controls
  • skin/coat/nails phenotype
  • partial hair loss (MGI Ref ID J:134519)
    • hind end hair loss
  • hearing/vestibular/ear phenotype
  • *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:134519)
    • ABR assessment normal
  • vision/eye phenotype
  • *normal* vision/eye phenotype (MGI Ref ID J:134519)
    • normal by ERG and opthalamascopic examination

Gene & Allele Details

Allele Symbol Clcn1adr-mto9J
Allele Name myotonia 9 Jackson
Strain of OriginC57BL/6J
Gene Symbol and Name Clcn1, chloride channel 1
Chromosome 6
Gene Common Name(s) CLC1; Clc-1; Clc1; MGC138361; MGC142055; NMF355; SMCC; SMCC1; adr; arrested development of righting response; mto; myotonia; neuroscience mutagenesis facility, 355; nmf310; nmf355;

Control Information

  Control
   Untested +/? from the colony
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Clcn1     (6 strains)

References

Selected Reference(s)

Harris B; Ward Bailey P; Johnson K; Bronson R. 2008. Myotonia 9 Jackson; a new mutation in the Clcn1 gene MGI Direct Data Submission :.  [MGI Ref ID J:134519]

Price and Supply Information

Strain Name: C57BL/6J-Clcn1adr-mto9J/J
Stock Number: 008253

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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