Strain Name:

C57BL/6J-hlb52/J

Stock Number:

008270

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Chemically Induced Mutation; Coisogenic;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
H2 Haplotypeb

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

hlb52/hlb52

        C57BL/6J-hlb52/J
  • adipose tissue phenotype
  • increased percent body fat (MGI Ref ID J:82961)
    • percent body fat of 12 week old females on a high fat, high cholesterol diet is 28.3%
  • growth/size phenotype
  • increased susceptibility to diet-induced obesity (MGI Ref ID J:82961)
    • body weight of 12 week old females on a high fat, high cholesterol diet is 21.5 grams, which is comparable to C57BL/6J controls on the same diet
  • homeostasis/metabolism phenotype
  • increased susceptibility to diet-induced obesity (MGI Ref ID J:82961)
    • body weight of 12 week old females on a high fat, high cholesterol diet is 21.5 grams, which is comparable to C57BL/6J controls on the same diet

hlb52/?

        C57BL/6J-hlb52/J
  • adipose tissue phenotype
  • increased percent body fat (MGI Ref ID J:82961)
    • at age 12 weeks, percent body fat = 28.3 after consuming an atherogenic diet for 4 weeks
  • growth/size phenotype
  • increased body weight (MGI Ref ID J:82961)
    • at age 12 weeks, body weight = 21.5 grams after consuming an atherogenic diet for 4 weeks
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype (MGI Ref ID J:82961)
    • insulin = 0.659 pg/ml, leptin = 13.29 ng/ml
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Obesity Without Diabetes

Genes & Alleles

Gene & Allele Information

Allele Symbol hlb52
Allele Name heart, lung and blood, 52
Allele Type Chemically induced (ENU)
Strain of OriginC57BL/6J
Molecular Note This mutation was discovered in an ENU mutagenesis screen.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

hlb52 related

JAX National Heart, Lung and Blood Program for Genomic Applications (PGA) URL: http://pga.jax.org. 2003. Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program MGI Direct Data Submission :.  [MGI Ref ID J:82961]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Mouse Heart, Lung, Blood and Sleep Disorders Center collection.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

Contracts Administration

phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

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MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.


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