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Strain Name:

BALB/cJ-Agtpbp1pcd-8J/J

Stock Number:

008292

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Agtpbp1;   Agtpbp1pcd-8J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Mating SystemOvarian Transplant-Cross-Intercross         (Female x Male)
homozygous ovarian transplant hosts x +/? males then obligate heterozygote x heterozygote intercross.
Specieslaboratory mouse

Strain Development
The Purkinje cell degeneration 8 Jackson mutation arose spontaneously in the BALB/cJ inbred strain at The Jackson Laboratory in 2004 and has been maintained on this background through sibling inbreeding ever since.

Mammalian Phenotype Terms assigned by genotype

Agtpbp1pcd-8J/Agtpbp1pcd-8J

        BALB/cJ-Agtpbp1pcd-8J/J
  • behavior/neurological phenotype
  • ataxia (MGI Ref ID J:132487)
    • moderate ataxia found by 3 to 4 weeks of age
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:132487)
  • nervous system phenotype
  • decreased Purkinje cell number (MGI Ref ID J:132487)
  • reproductive system phenotype
  • abnormal male germ cell morphology (MGI Ref ID J:132487)
    • abnormal sperm in one 19 week old male
  • male infertility (MGI Ref ID J:132487)
    • males do not breed
  • reduced female fertility (MGI Ref ID J:132487)
    • females are very poor breeders
  • vision/eye phenotype
  • abnormal retinal layer morphology (MGI Ref ID J:132487)
    • thin retinal vessels found in one 4 month old female and low rod and cone detection in one 6 week old male
  • retinal degeneration (MGI Ref ID J:132487)

Gene & Allele Details

Allele Symbol Agtpbp1pcd-8J
Allele Name Purkinje cell degeneration 8 Jackson
Strain of OriginBALB/cJ
Gene Symbol and Name Agtpbp1, ATP/GTP binding protein 1
Chromosome 13
Gene Common Name(s) 1700020N17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; BB114605; DKFZp686M20191; KIAA1035; NNA1; Purkinje cell degeneration; RIKEN cDNA 1700020N17 gene; RIKEN cDNA 2900054O13 gene; RIKEN cDNA 4930445M19 gene; RIKEN cDNA 5730402G09 gene; expressed sequence BB114605; nmf243; pcd;
Molecular Note Non-complementation with the Purkinje cell degeneration 3 Jackson mutant proved that these two mutations are allelic.

Control Information

  Control
   +/? from the colony
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Agtpbp1
000537   B6.BR-Agtpbp1pcd/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
003237   BALB/cByJ-Agtpbp1pcd-3J/J
005501   C(Cg)-Agtpbp1pcd-7J/J
005011   C57BL/6J-Agtpbp1pcd-6J/J
004518   DBA/2J-Agtpbp1pcd-5J/J
View Strains carrying other alleles of Agtpbp1     (6 strains)

Animal Health Reports

Room Number           A1

Research Applications

This mouse can be used to support research in many areas including:

Agtpbp1pcd-8J related

Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects (Purkinje cell defect)
Neurodegeneration

Sensorineural Research
Retinal Degeneration

References

Selected Reference(s)

Karst SY; Ward-Bailey PF; Samples R; Johnson KR; Donahue LR; Davisson MT. 2008. Purkinje cell degeneration 8 Jackson, a remutation to the Agtpbp1 gene MGI Direct Data Submission :.  [MGI Ref ID J:132487]

Price and Supply Information

Strain Name: BALB/cJ-Agtpbp1pcd-8J/J
Stock Number: 008292

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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