Strain Name:

B6.129(Cg)-Slc6a4tm1Kpl/J

Stock Number:

008355

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Availability:

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Use Restrictions Apply, see Terms of Use
These Slc6a4 knock-out mice may be useful in studying the role of serotonin and serotonin transporter in neurological functions and disorders.

Description

Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHeterozygote x Homozygote         (Female x Male)   24-NOV-09
HET fem x HOM male (NO RECIP), breed only after 8 weeks old. Please monitor litter frequency and size as anxiety pheno may lead to poor mothering and odd breeding results.
Specieslaboratory mouse
GenerationN25+1F12 (17-DEC-13)
Generation Definitions
 
Donating Investigator Dennis L Murphy,   NIH, NIMH, LCS

Description
Mice that are homozygous for the serotonin transporter targeted mutation (SERT-/- or 5-HTT-/-) are viable and fertile with a superficially unremarkable behavioral phenotype through early adulthood. Serotonin uptake is completely absent in homozygous mice. SERT-deficiency is pleiotropic (many different phenotypic traits). Homozygotes and, to a lesser extent, heterozygotes exhibit diminished responses to serotonin receptor agonists and other classes of drugs (including MDMA, SSRIs, 8-OH-DPAT, and DOI). SERT-mutant mice are also reported to have increased anxiety-like behaviors, altered neuroendocrine and sympathoadrenal responses to even minor stress, diminished aggression, altered emotional learning, substantially increased rapid eye movement (REM) sleep time, reduced brain excitability, increased body temperature, increased colonic motility, reduced spinal reflex to injury, reduced bladder response to stretching, blood pressure responses, diminished bone and muscle strength, reduced physical activity and exercise, and obesity associated with hyperglycemia and increased plasma levels of insulin, leptin, triglycerides and cholesterol. These SERT (or 5-HTT) mutant mice may be useful in studying the role of serotonin and serotonin transporter in behavior and learning, social anxiety, neuropsychiatric and neurological disorders (such as autism), pharmacological actions of therapeutic agents or drugs of abuse, inflammatory bowel disease, obesity and type 2 diabetes and other molecular consequences of SERT inactivation.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A targeting vector was designed to replace exon 2 of the targeted gene with a PGK-neo cassette. The construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and the resulting chimeric males were bred with C57BL/6J (and/or CD1) females to generate SERT (or 5-HTT) mutant mice. These mice were subsequently backcrossed to C57BL/6J mice for at least 24-25 generations prior to arrival at The Jackson Laboratory. Upon arrival, mice were bred with C57BL/6J for at least one generation to establish the colony.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Slc6a4
011088   C57BL/6-Slc6a4tm1(SLC6A4)Kres/J
011089   C57BL/6-Slc6a4tm2(SLC6A4)Kres/J
View Strains carrying other alleles of Slc6a4     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Autism
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Anxiety   (SLC6A4)
Obsessive-Compulsive Disorder; OCD   (SLC6A4)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Slc6a4tm1Kpl/Slc6a4+

        B6.129-Slc6a4tm1Kpl
  • behavior/neurological phenotype
  • abnormal social investigation
    • 8 week old females show a trend towards decreased preference for interacting with a stimulus mouse in a social approach assay, however this does not reach significance   (MGI Ref ID J:144937)
    • while 8 week old males do not show a change in preference for social interaction for the first trial, upon reexposure to the same social target in trial 2, males do not show attenuation of preference for social investigation between the first and second trials as seen in wild-type mice, indicating impaired social recognition in male   (MGI Ref ID J:144937)
  • nervous system phenotype
  • increased brain weight   (MGI Ref ID J:144937)
  • growth/size/body phenotype
  • megacephaly   (MGI Ref ID J:144937)

Slc6a4tm1Kpl/Slc6a4tm1Kpl

        B6.129-Slc6a4tm1Kpl
  • behavior/neurological phenotype
  • abnormal response to novel object
    • buried significantly fewer marbles than control   (MGI Ref ID J:108880)
  • behavioral despair
    • showed exaggerated immobility in response to repeated, but not acute, exposure to the tail suspension test   (MGI Ref ID J:108880)
  • decreased exploration in new environment
    • traveled a significantly shorter distance in the open field   (MGI Ref ID J:108880)
    • spent significantly less time in the center of the open field   (MGI Ref ID J:108880)
  • social withdrawal
    • male mutant mice spend more time in an empty cage than in a cage with a strange mouse in the sociability choice test; female mutant mice did not behave differently than controls   (MGI Ref ID J:151144)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Slc6a4tm1Kpl/Slc6a4+

        involves: 129S1/Sv * 129X1/SvJ * CD-1
  • behavior/neurological phenotype
  • hyperactivity
    • cumulative (+)3,4-methylenedioxymethamphetamine (MDMA) induced hyperactivity is reduced by about 50% compared to wild-type   (MGI Ref ID J:76020)

Slc6a4tm1Kpl/Slc6a4+

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
  • nervous system phenotype
  • abnormal barrel cortex morphology
    • the barrel septa in layer IV of the somatosensory cortex are enlarged   (MGI Ref ID J:71182)
  • behavior/neurological phenotype
  • enhanced conditioned place preference behavior
    • cocaine-conditioned place preference is significantly enhanced compared to wild-type mice   (MGI Ref ID J:48275)

Slc6a4tm1Kpl/Slc6a4tm1Kpl

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
  • behavior/neurological phenotype
  • abnormal sleep pattern
    • increased REM sleep bouts, more bouts of short duration, and less wake time are seen in mutants compared to wild-type mice   (MGI Ref ID J:89835)
  • abnormal thermal nociception
    • no thermal hyperalgesia is seen after unilateral chronic constrictive sciatic nerve injury unlike in wild-type mice   (MGI Ref ID J:81734)
  • enhanced conditioned place preference behavior
    • cocaine-conditioned place preference is significantly enhanced compared to wild-type mice   (MGI Ref ID J:48275)
  • cardiovascular system phenotype
  • abnormal heart ventricle morphology
    • left ventricular weight/body weight is lower in mutants   (MGI Ref ID J:62768)
    • after 5 weeks under hypoxic conditions right ventricular/left ventricular + septum weight is not increased in mutants unlike in wild-type mice   (MGI Ref ID J:62768)
    • heart right ventricle hypertrophy
      • right ventricular hypertrophy is less severe after prolonged hypoxia (2-5 weeks) compared to wild-type mice   (MGI Ref ID J:62768)
  • abnormal pulmonary artery morphology
    • hypoxia-induced thickening of the distal pulmonary vessels is reduced in mutants compared to wild-type mice   (MGI Ref ID J:62768)
  • increased right ventricle systolic pressure
    • a greater increase in right ventricular systolic pressure is seen after 5 minutes under hypoxic conditions less than 8% O2) in mutants compared to wild-type mice   (MGI Ref ID J:62768)
    • however prolonged hypoxia (2-5 weeks) produces a smaller increase in right ventricular systolic pressure compared to wild-type   (MGI Ref ID J:62768)
  • nervous system phenotype
  • abnormal brain morphology
    • the number of apoptotic cells in the brain is significantly decreased in neonatal mutants   (MGI Ref ID J:89816)
  • homeostasis/metabolism phenotype
  • abnormal serotonin level
    • whole blood serotonin levels are also significantly decreased   (MGI Ref ID J:62768)
  • integument phenotype
  • abnormal thermal nociception
    • no thermal hyperalgesia is seen after unilateral chronic constrictive sciatic nerve injury unlike in wild-type mice   (MGI Ref ID J:81734)

Slc6a4tm1Kpl/Slc6a4tm1Kpl

        involves: 129S1/Sv * 129X1/SvJ * CD-1
  • homeostasis/metabolism phenotype
  • abnormal body temperature homeostasis
    • no hypothermia in response to 8-hydroxy-2-(di-n-propylamino)tetraline treatment is seen unlike in wild-type mice   (MGI Ref ID J:59654)
  • abnormal serotonin level
    • a 60-80% decrease in serotonin levels in the brain stem, frontal cortex, hippocampus, and striatum is seen   (MGI Ref ID J:76020)
  • behavior/neurological phenotype
  • hypoactivity
    • (+)3,4-methylenedioxymethamphetamine (MDMA) does not induce hyperactivity but instead results in hypoactivity 10 and 30 minutes after treatment   (MGI Ref ID J:76020)

Slc6a4tm1Kpl/Slc6a4tm1Kpl

        involves: 129S1/Sv * 129X1/SvJ * C57BL/6
  • homeostasis/metabolism phenotype
  • abnormal serotonin level
    • whole blood 5-HT levels are reduced   (MGI Ref ID J:121505)
  • cardiac fibrosis
    • develop cardiac fibrosis, with significantly more collagen in myocardial and valvular regions   (MGI Ref ID J:121505)
  • cardiovascular system phenotype
  • abnormal heart valve morphology
    • in valvular regions, show leaflet thickening and marked collagen accumulation at the attachment site and in the leaflet itself   (MGI Ref ID J:121505)
    • these lesions are homogeneously distributed in the mitral, tricuspid, aortic, and pulmonary valves   (MGI Ref ID J:121505)
    • several areas of chondroid metaplasia are seen within the valvular tissue   (MGI Ref ID J:121505)
    • heart valve hyperplasia
      • leaflet thickening in valvular regions   (MGI Ref ID J:121505)
  • cardiac fibrosis
    • develop cardiac fibrosis, with significantly more collagen in myocardial and valvular regions   (MGI Ref ID J:121505)
  • decreased cardiac muscle contractility
    • decreased fractional shortening   (MGI Ref ID J:121505)
  • dilated cardiomyopathy
    • increased left ventricular lumen diameter and myocardial hypokinesis (decreased fractional shortening)   (MGI Ref ID J:121505)
  • muscle phenotype
  • decreased cardiac muscle contractility
    • decreased fractional shortening   (MGI Ref ID J:121505)
  • dilated cardiomyopathy
    • increased left ventricular lumen diameter and myocardial hypokinesis (decreased fractional shortening)   (MGI Ref ID J:121505)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cardiovascular Research
Hypercholesterolemia
Other
      altered fat metabolism

Cell Biology Research
Channel and Transporter Defects

Diabetes and Obesity Research
Hyperglycemia
Hyperinsulinemia

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Inflammatory bowel disease
Inflammation
      Inflammatory bowel disease

Internal/Organ Research
Bladder
Gastrointestinal Defects
      colitis

Metabolism Research
Lipid Metabolism

Neurobiology Research
Behavioral and Learning Defects
      high anxiety
Channel and Transporter Defects
Neurodevelopmental Defects
      Autism
Neuromuscular Defects
Neurotransmitter Receptor and Synaptic Vesicle Defects
Receptor Defects
      serotonin

Research Tools
Cardiovascular Research
Cell Biology Research
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Metabolism Research
Neurobiology Research
Toxicology Research
      drug/compound testing

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Slc6a4tm1Kpl
Allele Name targeted mutation 1, Klaus-Peter Lesch
Allele Type Targeted (Null/Knockout)
Common Name(s) 5-HTT KO; 5-HTT-; SERT -;
Mutation Made By Klaus-Peter Lesch,   University of W┐rzburg
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Slc6a4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Chromosome 11
Gene Common Name(s) 5-HTT; 5-HTTLPR; 5-hydroxytryptamine (serotonin) transporter; 5HTT; AI323329; HTT; Htt; OCD1; SERT; SERT1; expressed sequence AI323329; hSERT;
Molecular Note A neomycin selection cassette replaced a DNA segment containing exon 2. Binding assays on brain sections of adult homozygous mice confirmed that no functional protein was expressed from this allele. [MGI Ref ID J:76020]

Genotyping

Genotyping Information

Genotyping Protocols

Slc6a4tm1Kpl, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Bengel D; Murphy DL; Andrews AM; Wichems CH; Feltner D; Heils A; Mossner R; Westphal H; Lesch KP. 1998. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol 53(4):649-55. [PubMed: 9547354]  [MGI Ref ID J:76020]

Holmes A; Lit Q; Murphy DL; Gold E; Crawley JN. 2003. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav 2(6):365-80. [PubMed: 14653308]  [MGI Ref ID J:101947]

Murphy DL; Lesch KP. 2008. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9(2):85-96. [PubMed: 18209729]  [MGI Ref ID J:137336]

Additional References

Slc6a4tm1Kpl related

Adamec R; Burton P; Blundell J; Murphy DL; Holmes A. 2006. Vulnerability to mild predator stress in serotonin transporter knockout mice. Behav Brain Res 170(1):126-40. [PubMed: 16546269]  [MGI Ref ID J:108347]

Alexandre C; Popa D; Fabre V; Bouali S; Venault P; Lesch KP; Hamon M; Adrien J. 2006. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J Neurosci 26(20):5554-64. [PubMed: 16707806]  [MGI Ref ID J:108707]

Altamura C; Dell'Acqua ML; Moessner R; Murphy DL; Lesch KP; Persico AM. 2007. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex 17(6):1394-401. [PubMed: 16905592]  [MGI Ref ID J:156511]

Armando I; Tjurmina OA; Li Q; Murphy DL; Saavedra JM. 2003. The serotonin transporter is required for stress-evoked increases in adrenal catecholamine synthesis and angiotensin II AT(2) receptor expression. Neuroendocrinology 78(4):217-25. [PubMed: 14583654]  [MGI Ref ID J:118735]

Asada M; Ebihara S; Yamanda S; Niu K; Okazaki T; Sora I; Arai H. 2009. Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 11(4):408-17. [PubMed: 19308295]  [MGI Ref ID J:162980]

Baganz N; Horton R; Martin K; Holmes A; Daws LC. 2010. Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. J Neurosci 30(45):15185-95. [PubMed: 21068324]  [MGI Ref ID J:166451]

Baganz NL; Horton RE; Calderon AS; Owens WA; Munn JL; Watts LT; Koldzic-Zivanovic N; Jeske NA; Koek W; Toney GM; Daws LC. 2008. Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc Natl Acad Sci U S A 105(48):18976-81. [PubMed: 19033200]  [MGI Ref ID J:142248]

Bartolomucci A; Carola V; Pascucci T; Puglisi-Allegra S; Cabib S; Lesch KP; Parmigiani S; Palanza P; Gross C. 2010. Increased vulnerability to psychosocial stress in heterozygous serotonin transporter knockout mice. Dis Model Mech 3(7-8):459-70. [PubMed: 20371729]  [MGI Ref ID J:159212]

Bearer EL; Zhang X; Janvelyan D; Boulat B; Jacobs RE. 2009. Reward circuitry is perturbed in the absence of the serotonin transporter. Neuroimage 46(4):1091-104. [PubMed: 19306930]  [MGI Ref ID J:157289]

Bonnin A; Goeden N; Chen K; Wilson ML; King J; Shih JC; Blakely RD; Deneris ES; Levitt P. 2011. A transient placental source of serotonin for the fetal forebrain. Nature 472(7343):347-50. [PubMed: 21512572]  [MGI Ref ID J:171595]

Bouali S; Evrard A; Chastanet M; Lesch KP; Hamon M; Adrien J. 2003. Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter. Eur J Neurosci 18(8):2203-12. [PubMed: 14622181]  [MGI Ref ID J:89670]

Brigman JL; Mathur P; Harvey-White J; Izquierdo A; Saksida LM; Bussey TJ; Fox S; Deneris E; Murphy DL; Holmes A. 2010. Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex 20(8):1955-63. [PubMed: 20032063]  [MGI Ref ID J:174475]

Carneiro AM; Cook EH; Murphy DL; Blakely RD. 2008. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 118(4):1544-52. [PubMed: 18317590]  [MGI Ref ID J:135834]

Carola V; Pascucci T; Puglisi-Allegra S; Cabib S; Gross C. 2011. Effect of the interaction between the serotonin transporter gene and maternal environment on developing mouse brain. Behav Brain Res 217(1):188-94. [PubMed: 20974189]  [MGI Ref ID J:167557]

Carroll JC; Boyce-Rustay JM; Millstein R; Yang R; Wiedholz LM; Murphy DL; Holmes A. 2007. Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice. Behav Genet 37(1):214-22. [PubMed: 17177116]  [MGI Ref ID J:147555]

Chen JJ; Li Z; Pan H; Murphy DL; Tamir H; Koepsell H; Gershon MD. 2001. Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J Neurosci 21(16):6348-61. [PubMed: 11487658]  [MGI Ref ID J:110920]

Chen X; Margolis KJ; Gershon MD; Schwartz GJ; Sze JY. 2012. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PLoS One 7(3):e32511. [PubMed: 22412882]  [MGI Ref ID J:186933]

Cloutier N; Pare A; Farndale RW; Schumacher HR; Nigrovic PA; Lacroix S; Boilard E. 2012. Platelets can enhance vascular permeability. Blood 120(6):1334-43. [PubMed: 22544703]  [MGI Ref ID J:188638]

Cornelissen LL; Brooks DP; Wibberley A. 2005. Female, but not male, serotonin reuptake transporter (5-HTT) knockout mice exhibit bladder instability. Auton Neurosci 122(1-2):107-10. [PubMed: 16023897]  [MGI Ref ID J:106378]

Cyphert JM; Kovarova M; Allen IC; Hartney JM; Murphy DL; Wess J; Koller BH. 2009. Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol 182(12):7430-9. [PubMed: 19494266]  [MGI Ref ID J:149438]

Daws LC; Montanez S; Munn JL; Owens WA; Baganz NL; Boyce-Rustay JM; Millstein RA; Wiedholz LM; Murphy DL; Holmes A. 2006. Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. J Neurosci 26(24):6431-8. [PubMed: 16775130]  [MGI Ref ID J:109597]

Eddahibi S; Hanoun N; Lanfumey L; Lesch KP; Raffestin B; Hamon M; Adnot S. 2000. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene J Clin Invest 105(11):1555-62. [PubMed: 10841514]  [MGI Ref ID J:62768]

Esaki T; Cook M; Shimoji K; Murphy DL; Sokoloff L; Holmes A. 2005. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci U S A 102(15):5582-5587. [PubMed: 15809439]  [MGI Ref ID J:97814]

Fabre V; Beaufour C; Evrard A; Rioux A; Hanoun N; Lesch KP; Murphy DL; Lanfumey L; Hamon M; Martres MP. 2000. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci 12(7):2299-310. [PubMed: 10947809]  [MGI Ref ID J:108085]

Garcia-Frigola C; Herrera E. 2010. Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. EMBO J 29(18):3170-83. [PubMed: 20676059]  [MGI Ref ID J:164404]

Gobbi G; Murphy DL; Lesch K; Blier P. 2001. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. J Pharmacol Exp Ther 296(3):987-95. [PubMed: 11181933]  [MGI Ref ID J:126697]

Hall FS; Li XF; Randall-Thompson J; Sora I; Murphy DL; Lesch KP; Caron M; Uhl GR. 2009. Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. Neuroscience 162(4):870-80. [PubMed: 19482066]  [MGI Ref ID J:153187]

Hall FS; Li XF; Sora I; Xu F; Caron M; Lesch KP; Murphy DL; Uhl GR. 2002. Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. Neuroscience 115(1):153-61. [PubMed: 12401330]  [MGI Ref ID J:120008]

Hall FS; Schwarzbaum JM; Perona MT; Templin JS; Caron MG; Lesch KP; Murphy DL; Uhl GR. 2011. A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. Neuroscience 175:315-27. [PubMed: 21129446]  [MGI Ref ID J:170233]

Hansen N; Uceyler N; Palm F; Zelenka M; Biko L; Lesch KP; Gerlach M; Sommer C. 2011. Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy. Neurosci Lett 495(2):93-7. [PubMed: 21419830]  [MGI Ref ID J:172871]

Haub S; Kanuri G; Volynets V; Brune T; Bischoff SC; Bergheim I. 2010. Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. Am J Physiol Gastrointest Liver Physiol 298(3):G335-44. [PubMed: 19713474]  [MGI Ref ID J:157885]

Heiming RS; Monning A; Jansen F; Kloke V; Lesch KP; Sachser N. 2013. To attack, or not to attack? The role of serotonin transporter genotype in the display of maternal aggression. Behav Brain Res 242:135-41. [PubMed: 23291155]  [MGI Ref ID J:197063]

Hohoff C; Gorji A; Kaiser S; Willscher E; Korsching E; Ambree O; Arolt V; Lesch KP; Sachser N; Deckert J; Lewejohann L. 2013. Effect of acute stressor and serotonin transporter genotype on amygdala first wave transcriptome in mice. PLoS One 8(3):e58880. [PubMed: 23536833]  [MGI Ref ID J:199900]

Holmes A; Murphy DL; Crawley JN. 2003. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 54(10):953-9. [PubMed: 14625137]  [MGI Ref ID J:102629]

Holmes A; Murphy DL; Crawley JN. 2002. Reduced aggression in mice lacking the serotonin transporter. Psychopharmacology (Berl) 161(2):160-7. [PubMed: 11981596]  [MGI Ref ID J:103888]

Holmes A; Yang RJ; Lesch KP; Crawley JN; Murphy DL. 2003. Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 28(12):2077-88. [PubMed: 12968128]  [MGI Ref ID J:134102]

Holmes A; Yang RJ; Murphy DL; Crawley JN. 2002. Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 27(6):914-23. [PubMed: 12464448]  [MGI Ref ID J:106213]

Horng S; Kreiman G; Ellsworth C; Page D; Blank M; Millen K; Sur M. 2009. Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development. J Neurosci 29(43):13672-83. [PubMed: 19864579]  [MGI Ref ID J:154445]

Ichikawa M; Okamura-Oho Y; Shimokawa K; Kondo S; Nakamura S; Yokota H; Himeno R; Lesch KP; Hayashizaki Y. 2008. Expression analysis for inverted effects of serotonin transporter inactivation. Biochem Biophys Res Commun 368(1):43-9. [PubMed: 18211820]  [MGI Ref ID J:132665]

Ineichen C; Sigrist H; Spinelli S; Lesch KP; Sautter E; Seifritz E; Pryce CR. 2012. Establishing a probabilistic reversal learning test in mice: evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin. Neuropharmacology 63(6):1012-21. [PubMed: 22824190]  [MGI Ref ID J:188928]

Jansen F; Heiming RS; Lewejohann L; Touma C; Palme R; Schmitt A; Lesch KP; Sachser N. 2010. Modulation of behavioural profile and stress response by 5-HTT genotype and social experience in adulthood. Behav Brain Res 207(1):21-9. [PubMed: 19782704]  [MGI Ref ID J:154914]

Jennings KA; Lesch KP; Sharp T; Cragg SJ. 2010. Non-linear relationship between 5-HT transporter gene expression and frequency sensitivity of 5-HT signals. J Neurochem 115(4):965-73. [PubMed: 20854367]  [MGI Ref ID J:166610]

Joeyen-Waldorf J; Edgar N; Sibille E. 2009. The roles of sex and serotonin transporter levels in age- and stress-related emotionality in mice. Brain Res 1286:84-93. [PubMed: 19577546]  [MGI Ref ID J:157216]

Kalueff AV; Fox MA; Gallagher PS; Murphy DL. 2007. Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. Genes Brain Behav 6(4):389-400. [PubMed: 16939636]  [MGI Ref ID J:137287]

Kalueff AV; Gallagher PS; Murphy DL. 2006. Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia. Neuroreport 17(12):1347-51. [PubMed: 16951583]  [MGI Ref ID J:112396]

Kalueff AV; Jensen CL; Murphy DL. 2007. Locomotory patterns, spatiotemporal organization of exploration and spatial memory in serotonin transporter knockout mice. Brain Res 1169:87-97. [PubMed: 17692295]  [MGI Ref ID J:125727]

Karabeg MM; Grauthoff S; Kollert SY; Weidner M; Heiming RS; Jansen F; Popp S; Kaiser S; Lesch KP; Sachser N; Schmitt AG; Lewejohann L. 2013. 5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze. PLoS One 8(10):e78238. [PubMed: 24167611]  [MGI Ref ID J:209195]

Kayser V; Elfassi IE; Aubel B; Melfort M; Julius D; Gingrich JA; Hamon M; Bourgoin S. 2007. Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A-/-, 5-HT1B-/-, 5-HT2A-/-, 5-HT3A-/- and 5-HTT-/- knock-out male mice. Pain 130(3):235-48. [PubMed: 17250964]  [MGI Ref ID J:124500]

Kelai S; Aissi F; Lesch KP; Cohen-Salmon C; Hamon M; Lanfumey L. 2003. Alcohol intake after serotonin transporter inactivation in mice. Alcohol Alcohol 38(4):386-9. [PubMed: 12814910]  [MGI Ref ID J:101997]

Kim DK; Tolliver TJ; Huang SJ; Martin BJ; Andrews AM; Wichems C; Holmes A; Lesch KP; Murphy DL. 2005. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology 49(6):798-810. [PubMed: 16183083]  [MGI Ref ID J:106593]

Kloke V; Heiming RS; Bolting S; Kaiser S; Lewejohann L; Lesch KP; Sachser N. 2013. Unexpected effects of early-life adversity and social enrichment on the anxiety profile of mice varying in serotonin transporter genotype. Behav Brain Res 247:248-58. [PubMed: 23567893]  [MGI Ref ID J:197685]

Lewejohann L; Kloke V; Heiming RS; Jansen F; Kaiser S; Schmitt A; Lesch KP; Sachser N. 2010. Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behav Brain Res 211(2):220-8. [PubMed: 20347882]  [MGI Ref ID J:159672]

Li A; Nattie E. 2008. Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J Physiol 586(9):2321-9. [PubMed: 18356199]  [MGI Ref ID J:176399]

Li Q; Wichems C; Heils A; Lesch KP; Murphy DL. 2000. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-Out mice: gender and brain region differences J Neurosci 20(21):7888-95. [PubMed: 11050108]  [MGI Ref ID J:65197]

Li Q; Wichems C; Heils A; Van De Kar LD; Lesch KP; Murphy DL. 1999. Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther 291(3):999-1007. [PubMed: 10565817]  [MGI Ref ID J:59654]

Li Q; Wichems CH; Ma L; Van de Kar LD; Garcia F; Murphy DL. 2003. Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice. J Neurochem 84(6):1256-65. [PubMed: 12614326]  [MGI Ref ID J:82425]

Li Z; Chalazonitis A; Huang YY; Mann JJ; Margolis KG; Yang QM; Kim DO; Cote F; Mallet J; Gershon MD. 2011. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J Neurosci 31(24):8998-9009. [PubMed: 21677183]  [MGI Ref ID J:173536]

Liu MT; Rayport S; Jiang Y; Murphy DL; Gershon MD. 2002. Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter. Am J Physiol Gastrointest Liver Physiol 283(6):G1398-411. [PubMed: 12388212]  [MGI Ref ID J:108053]

Mannoury la Cour C; Boni C; Hanoun N; Lesch KP; Hamon M; Lanfumey L. 2001. Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity. J Neurosci 21(6):2178-85. [PubMed: 11245702]  [MGI Ref ID J:109479]

Mathews TA; Fedele DE; Coppelli FM; Avila AM; Murphy DL; Andrews AM. 2004. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 140(1-2):169-81. [PubMed: 15589347]  [MGI Ref ID J:101809]

Mekontso-Dessap A; Brouri F; Pascal O; Lechat P; Hanoun N; Lanfumey L; Seif I; Benhaiem-Sigaux N; Kirsch M; Hamon M; Adnot S; Eddahibi S. 2006. Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation 113(1):81-9. [PubMed: 16380550]  [MGI Ref ID J:121505]

Mercado CP; Quintero MV; Li Y; Singh P; Byrd AK; Talabnin K; Ishihara M; Azadi P; Rusch NJ; Kuberan B; Maroteaux L; Kilic F. 2013. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep 3:2795. [PubMed: 24077408]  [MGI Ref ID J:207791]

Montanez S; Owens WA; Gould GG; Murphy DL; Daws LC. 2003. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. J Neurochem 86(1):210-9. [PubMed: 12807440]  [MGI Ref ID J:84038]

Mossner R; Simantov R; Marx A; Lesch KP; Seif I. 2006. Aberrant accumulation of serotonin in dopaminergic neurons. Neurosci Lett 401(1-2):49-54. [PubMed: 16638624]  [MGI Ref ID J:144910]

Moy SS; Nadler JJ; Young NB; Nonneman RJ; Grossman AW; Murphy DL; D'Ercole AJ; Crawley JN; Magnuson TR; Lauder JM. 2009. Social approach in genetically engineered mouse lines relevant to autism. Genes Brain Behav 8(2):129-42. [PubMed: 19016890]  [MGI Ref ID J:151144]

Murphy DL; Uhl GR; Holmes A; Ren-Patterson R; Hall FS; Sora I; Detera-Wadleigh S; Lesch KP. 2003. Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. Genes Brain Behav 2(6):350-64. [PubMed: 14653307]  [MGI Ref ID J:88545]

Narayanan V; Heiming RS; Jansen F; Lesting J; Sachser N; Pape HC; Seidenbecher T. 2011. Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice. PLoS One 6(7):e22600. [PubMed: 21818344]  [MGI Ref ID J:175855]

Ni W; Zhou H; Diaz J; Murphy DL; Haywood JR; Watts SW. 2008. Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse. Eur J Pharmacol 589(1-3):225-7. [PubMed: 18573249]  [MGI Ref ID J:145653]

Nietzer SL; Bonn M; Jansen F; Heiming RS; Lewejohann L; Sachser N; Asan ES; Lesch KP; Schmitt AG. 2011. Serotonin transporter knockout and repeated social defeat stress: Impact on neuronal morphology and plasticity in limbic brain areas. Behav Brain Res 220(1):42-54. [PubMed: 21238500]  [MGI Ref ID J:170636]

Olexova L; Talarovicova A; Lewis-Evans B; Borbelyova V; Krskova L. 2012. Animal models of autism with a particular focus on the neural basis of changes in social behaviour: an update article. Neurosci Res 74(3-4):184-94. [PubMed: 23142422]  [MGI Ref ID J:192363]

Page DT; Kuti OJ; Prestia C; Sur M. 2009. Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A 106(6):1989-94. [PubMed: 19208814]  [MGI Ref ID J:144937]

Pan Y; Gembom E; Peng W; Lesch KP; Mossner R; Simantov R. 2001. Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice. Brain Res Dev Brain Res 126(1):125-9. [PubMed: 11172895]  [MGI Ref ID J:109175]

Pang RD; Wang Z; Klosinski LP; Guo Y; Herman DH; Celikel T; Dong HW; Holschneider DP. 2011. Mapping functional brain activation using [C]-iodoantipyrine in male serotonin transporter knockout mice. PLoS One 6(8):e23869. [PubMed: 21886833]  [MGI Ref ID J:176156]

Persico AM; Baldi A; Dell'Acqua ML; Moessner R; Murphy DL; Lesch KP; Keller F. 2003. Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport 14(3):341-4. [PubMed: 12634480]  [MGI Ref ID J:89816]

Persico AM; Mengual E; Moessner R; Hall FS; Revay RS; Sora I; Arellano J; DeFelipe J; Gimenez-Amaya JM; Conciatori M; Marino R; Baldi A; Cabib S; Pascucci T; Uhl GR; Murphy DL; Lesch KP; Keller F; Hall SF. 2001. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 21(17):6862-73. [PubMed: 11517274]  [MGI Ref ID J:71182]

Popa D; Lena C; Alexandre C; Adrien J. 2008. Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior. J Neurosci 28(14):3546-54. [PubMed: 18385313]  [MGI Ref ID J:133675]

Pryce CR; Azzinnari D; Sigrist H; Gschwind T; Lesch KP; Seifritz E. 2012. Establishing a learned-helplessness effect paradigm in C57BL/6 mice: behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se. Neuropharmacology 62(1):358-72. [PubMed: 21864549]  [MGI Ref ID J:183570]

Qu Y; Villacreses N; Murphy DL; Rapoport SI. 2005. 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology (Berl) 180(1):12-20. [PubMed: 15834538]  [MGI Ref ID J:114225]

Rachalski A; Alexandre C; Bernard JF; Saurini F; Lesch KP; Hamon M; Adrien J; Fabre V. 2009. Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins. J Neurosci 29(49):15575-85. [PubMed: 20007481]  [MGI Ref ID J:156180]

Rantamaki T; Vesa L; Antila H; Di Lieto A; Tammela P; Schmitt A; Lesch KP; Rios M; Castren E. 2011. Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One 6(6):e20567. [PubMed: 21666748]  [MGI Ref ID J:174143]

Ravary A; Muzerelle A; Darmon M; Murphy DL; Moessner R; Lesch KP; Gaspar P. 2001. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur J Neurosci 13(7):1349-62. [PubMed: 11298795]  [MGI Ref ID J:89767]

Ren-Patterson RF; Cochran LW; Holmes A; Sherrill S; Huang SJ; Tolliver T; Lesch KP; Lu B; Murphy DL. 2005. Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J Neurosci Res 79(6):756-71. [PubMed: 15672416]  [MGI Ref ID J:109152]

Riccio O; Potter G; Walzer C; Vallet P; Szabo G; Vutskits L; Kiss JZ; Dayer AG. 2009. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Mol Psychiatry 14(3):280-90. [PubMed: 18663366]  [MGI Ref ID J:166115]

Rioux A; Fabre V; Lesch KP; Moessner R; Murphy DL; Lanfumey L; Hamon M; Martres MP. 1999. Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter. Neurosci Lett 262(2):113-6. [PubMed: 10203244]  [MGI Ref ID J:57213]

Rumajogee P; Verge D; Hanoun N; Brisorgueil MJ; Hen R; Lesch KP; Hamon M; Miquel MC. 2004. Adaption of the serotoninergic neuronal phenotype in the absence of 5-HT autoreceptors or the 5-HT transporter: involvement of BDNF and cAMP. Eur J Neurosci 19(4):937-44. [PubMed: 15009141]  [MGI Ref ID J:96498]

Salichon N; Gaspar P; Upton AL; Picaud S; Hanoun N; Hamon M; De Maeyer E; Murphy DL; Mossner R; Lesch KP; Hen R; Seif I. 2001. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci 21(3):884-96. [PubMed: 11157075]  [MGI Ref ID J:67191]

Schmitt A; Mossner R; Gossmann A; Fischer IG; Gorboulev V; Murphy DL; Koepsell H; Lesch KP. 2003. Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J Neurosci Res 71(5):701-9. [PubMed: 12584728]  [MGI Ref ID J:104937]

Sora I; Hall FS; Andrews AM; Itokawa M; Li XF; Wei HB; Wichems C; Lesch KP; Murphy DL; Uhl GR. 2001. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proc Natl Acad Sci U S A 98(9):5300-5. [PubMed: 11320258]  [MGI Ref ID J:93114]

Sora I; Wichems C; Takahashi N; Li XF; Zeng Z; Revay R; Lesch KP; Murphy DL; Uhl GR. 1998. Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci U S A 95(13):7699-704. [PubMed: 9636213]  [MGI Ref ID J:48275]

Szapacs ME; Mathews TA; Tessarollo L; Ernest Lyons W; Mamounas LA; Andrews AM. 2004. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. J Neurosci Methods 140(1-2):81-92. [PubMed: 15589338]  [MGI Ref ID J:101786]

Thomsen M; Hall FS; Uhl GR; Caine SB. 2009. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. J Neurosci 29(4):1087-92. [PubMed: 19176817]  [MGI Ref ID J:144826]

Tjurmina OA; Armando I; Saavedra JM; Goldstein DS; Murphy DL. 2002. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology 143(12):4520-6. [PubMed: 12446578]  [MGI Ref ID J:80505]

Trigo JM; Renoir T; Lanfumey L; Hamon M; Lesch KP; Robledo P; Maldonado R. 2007. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biol Psychiatry 62(6):669-79. [PubMed: 17306775]  [MGI Ref ID J:136593]

Upton AL; Ravary A; Salichon N; Moessner R; Lesch KP; Hen R; Seif I; Gaspar P. 2002. Lack of 5-HT(1B) receptor and of serotonin transporter have different effects on the segregation of retinal axons in the lateral geniculate nucleus compared to the superior colliculus. Neuroscience 111(3):597-610. [PubMed: 12031347]  [MGI Ref ID J:109402]

Van den Hove D; Jakob SB; Schraut KG; Kenis G; Schmitt AG; Kneitz S; Scholz CJ; Wiescholleck V; Ortega G; Prickaerts J; Steinbusch H; Lesch KP. 2011. Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions. PLoS One 6(8):e22715. [PubMed: 21857948]  [MGI Ref ID J:176504]

Vogel C; Mossner R; Gerlach M; Heinemann T; Murphy DL; Riederer P; Lesch KP; Sommer C. 2003. Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci 23(2):708-15. [PubMed: 12533631]  [MGI Ref ID J:81734]

Warden SJ; Robling AG; Sanders MS; Bliziotes MM; Turner CH. 2005. Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth. Endocrinology 146(2):685-93. [PubMed: 15539550]  [MGI Ref ID J:95781]

Wellman CL; Izquierdo A; Garrett JE; Martin KP; Carroll J; Millstein R; Lesch KP; Murphy DL; Holmes A. 2007. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci 27(3):684-91. [PubMed: 17234600]  [MGI Ref ID J:117435]

Wisor JP; Wurts SW; Hall FS; Lesch KP; Murphy DL; Uhl GR; Edgar DM. 2003. Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport 14(2):233-8. [PubMed: 12598736]  [MGI Ref ID J:89835]

Zhao S; Edwards J; Carroll J; Wiedholz L; Millstein RA; Jaing C; Murphy DL; Lanthorn TH; Holmes A. 2006. Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience 140(1):321-34. [PubMed: 16542782]  [MGI Ref ID J:108880]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, heterozygous or homozygous mice may be bred. The donating investigator breeds heterozygous females with homozygous males, and recommends monitoring litter frequency and sizes as the high anxiety observed in homozygous (and to a lesser extent heterozygous) females may result in undesirable maternal behaviors. The donating investigator also notes better breedings results if mice are placed in matings at no less than 8 weeks of age.
Mating SystemHeterozygote x Homozygote         (Female x Male)   24-NOV-09
HET fem x HOM male (NO RECIP), breed only after 8 weeks old. Please monitor litter frequency and size as anxiety pheno may lead to poor mothering and odd breeding results.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHeterozygous for Slc6a4tm1Kpl  
$239.00Female or MaleHomozygous for Slc6a4tm1Kpl  
Price per Pair (US dollars $)Pair Genotype
$478.00Heterozygous for Slc6a4tm1Kpl x Homozygous for Slc6a4tm1Kpl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHeterozygous for Slc6a4tm1Kpl  
$310.70Female or MaleHomozygous for Slc6a4tm1Kpl  
Price per Pair (US dollars $)Pair Genotype
$621.40Heterozygous for Slc6a4tm1Kpl x Homozygous for Slc6a4tm1Kpl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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