Former Names B6;129-Chattm1(cre/Esr1)Nat/J (Changed: 17-MAR-10 ) B6;129-Chattm1(Cre/Esr1)Nat/J (Changed: 02-SEP-09 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N?pN1
Generation DefinitionsDonating Investigator Jeremy Nathans, Johns Hopkins University Description
These targeted mutation mice carry a tamoxifen-inducible Cre cassette knocked into the 3' UTR of the gene. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating 4-hydroxytamoxifen-induced, Cre-mediated targeted deletions specifically in cholinergic neurons. Heterozygotes and homozygotes are normal in size, viability and fertility.Development
An IRES-creER cassette followed by an Frt-PGK-Neo-Frt selectable marker was knocked in to the 3' UTR of the gene using a 129-derived JHMI-ES1 embryonic stem cell line. The PGK-Neo was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. This strain was maintained on a mixed C57BL/6 and 129 background by the donating laboratory.
| Control | ||
|---|---|---|
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
Alzheimer's Disease Models
005987 129-Achetm1Loc/J 006409 129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax 008077 129S1/Sv-Bchetm1Loc/J 016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 014556 129S6/SvEv-Apoetm4Mae/J 006555 A.129(B6)-Tg(APPSw)40Btla/Mmjax 005708 B6.129-Apbb1tm1Quhu/J 004714 B6.129-Bace1tm1Pcw/J 004098 B6.129-Klc1tm1Gsn/J 007251 B6.129-Mapttm1Hnd/J 004193 B6.129-Psen1tm1Mpm/J 003615 B6.129-Psen1tm1Shn/J 005300 B6.129-Tg(APPSw)40Btla/Mmjax 005617 B6.129P-Psen2tm1Bdes/J 002609 B6.129P2-Nos2tm1Lau/J 007685 B6.129P2-Psen1tm1Vln/J 007999 B6.129P2-Sorl1Gt(Ex255)Byg/J 008087 B6.129S1-Bchetm1Loc/J 002509 B6.129S2-Plautm1Mlg/J 005301 B6.129S2-Tg(APP)8.9Btla/J 004163 B6.129S4-Cdk5r1tm1Lht/J 010959 B6.129S4-Grk5tm1Rjl/J 010960 B6.129S4-Grk5tm2Rjl/J 002213 B6.129S4-Ngfrtm1Jae/J 006406 B6.129S4-Tg(APPSwLon)96Btla/Mmjax 006469 B6.129S4-Tg(PSEN1H163R)G9Btla/J 012564 B6.129S5-Dhcr24tm1Lex/SbpaJ 004142 B6.129S7-Aplp2tm1Dbo/J 004133 B6.129S7-Apptm1Dbo/J 013040 B6.Cg-Apoetm1Unc Ins2Akita/J 005642 B6.Cg-Clutm1Jakh/J 005491 B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 009126 B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 005866 B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax 008730 B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 005864 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 007575 B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J 016197 B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 004996 B6.Cg-Tg(DBH-Gal)1923Stei/J 007673 B6.Cg-Tg(Gad1-EGFP)3Gfng/J 004662 B6.Cg-Tg(PDGFB-APP)5Lms/J 006293 B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax 006006 B6.Cg-Tg(Prnp-APP)A-2Dbo/J 008596 B6.Cg-Tg(Prnp-Abca1)EHol/J 006005 B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax 007180 B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J 007182 B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J 005999 B6.Cg-Tg(SBE/TK-luc)7Twc/J 012597 B6.Cg-Tg(Thy1-COL25A1)861Yfu/J 007051 B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax 007052 B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax 007049 B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax 009337 B6.FVB-Tg(Prnp-RTN3)2Yanr/J 006394 B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J 008476 B6;129-Ncstntm1Sud/J 004807 B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax 007605 B6;129P-Psen1tm1Vln/J 005618 B6;129P2-Bace2tm1Bdes/J 008333 B6;129P2-Dldtm1Ptl/J 002596 B6;129P2-Nos2tm1Lau/J 003822 B6;129S-Psen1tm1Shn/J 012639 B6;129S4-Mapttm3(HDAC2)Jae/J 012869 B6;129S6-Apbb2tm1Her/J 006410 B6;129S6-Chattm2(cre)Lowl/J 005993 B6;129S6-Pcsk9tm1Jdh/J 008636 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J 007002 B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax 008169 B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J 000231 B6;C3Fe a/a-Csf1op/J 008850 B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ 003378 B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J 004462 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 003741 B6D2-Tg(Prnp-MAPT)43Vle/J 016556 B6N.129-Ptpn5tm1Pjlo/J 006554 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax 012621 C.129S(B6)-Chrna3tm1.1Hwrt/J 002328 C.129S2-Plautm1Mlg/J 003375 C3B6-Tg(APP695)3Dbo/Mmjax 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J 008833 C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J 007027 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax 010800 C57BL/6-Tg(Thy1-PTGS2)300Kand/J 010703 C57BL/6-Tg(Thy1-PTGS2)303Kand/J 005706 C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 007677 CB6-Tg(Gad1-EGFP)G42Zjh/J 007072 CByJ.129P2(B6)-Nos2tm1Lau/J 006472 D2.129(B6)-Tg(APPSw)40Btla/Mmjax 007067 D2.129P2(B6)-Apoetm1Unc/J 013719 D2.Cg-Apoetm1Unc Ins2Akita/J 003718 FVB-Tg(GadGFP)45704Swn/J 013732 FVB-Tg(NPEPPS)1Skar/J 013156 FVB-Tg(tetO-CDK5R1*)1Vln/J 015815 FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ 002329 FVB.129S2-Plautm1Mlg/J 003753 FVB/N-Tg(Eno2CDK5R1)1Jdm/J 006143 FVB/N-Tg(Thy1-cre)1Vln/J 008051 NOD.129P2(B6)-Ctsbtm1Jde/RclJ 008390 STOCK Apptm1Sud/J 012640 STOCK Hdac2tm1.2Rdp/J 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 004779 STOCK Mapttm1(EGFP)Klt/J 014092 STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J 014544 STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J View Alzheimer's Disease Models (108 strains)
Parkinson's Disease Models
005987 129-Achetm1Loc/J 007587 129S-Park2tm1Rpa/J 002779 129S-Parp1tm1Zqw/J 017001 129S.B6N-Plk2tm1Elan/J 016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 004608 B6(Cg)-Htra2mnd2/J 008133 B6.129-Sncbtm1Sud/J 008084 B6.129P2-Drd4tm1Dkg/J 004744 B6.129P2-Esr1tm1Ksk/J 013586 B6.129P2-Gt(ROSA)26Sortm1Nik/J 002609 B6.129P2-Nos2tm1Lau/J 008843 B6.129P2-Sncgtm1Vlb/J 016566 B6.129S-Hcn1tm2Kndl/J 004322 B6.129S1-Mapk10tm1Flv/J 003190 B6.129S2-Drd2tm1Low/J 006582 B6.129S4-Park2tm1Shn/J 017946 B6.129S4-Pink1tm1Shn/J 005934 B6.129S4-Ucp2tm1Lowl/J 004936 B6.129S6(Cg)-Spp1tm1Blh/J 012453 B6.129X1(FVB)-Lrrk2tm1.1Cai/J 017009 B6.129X1-Nfe2l2tm1Ywk/J 009346 B6.Cg-Lrrk2tm1.1Shn/J 005491 B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 006577 B6.Cg-Park7tm1Shn/J 000567 B6.Cg-T2J +/+ Qkqk-v/J 007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 003139 B6.Cg-Tg(DBHn-lacZ)8Rpk/J 007673 B6.Cg-Tg(Gad1-EGFP)3Gfng/J 012466 B6.Cg-Tg(Lrrk2)6Yue/J 012467 B6.Cg-Tg(Lrrk2*G2019S)2Yue/J 008323 B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J 008321 B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J 008324 B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J 008322 B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J 007894 B6.Cg-Tg(Rgs4-EGFP)4Lvt/J 012588 B6.Cg-Tg(TH-ALPP)1Erav/J 012265 B6.Cg-Tg(THY1-SNCA*A30P)TS2Sud/J 008859 B6.Cg-Tg(THY1-SNCA*A53T)F53Sud/J 008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 008601 B6.Cg-Tg(Th-cre)1Tmd/J 013583 B6.Cg-Tg(tetO-LRRK2)C7874Cai/J 000544 B6.D2-Cacna1atg/J 012445 B6.FVB-Tg(LRRK2)WT1Mjfa/J 012446 B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J 006660 B6.SJL-Slc6a3tm1.1(cre)Bkmn/J 009688 B6;129-Dbhtm2(Th)Rpa Thtm1Rpa/J 008883 B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ 008889 B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ 008886 B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ 009347 B6;129-Lrrk2tm1.1Shn/J 016209 B6;129-Lrrk2tm2.1Shn/J 016210 B6;129-Lrrk2tm3.1Shn/J 013050 B6;129-Pink1tm1Aub/J 004807 B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax 006390 B6;129-Sncatm1Sud Sncbtm1.1Sud/J 008532 B6;129-Thtm1(cre/Esr1)Nat/J 008333 B6;129P2-Dldtm1Ptl/J 008333 B6;129P2-Dldtm1Ptl/J 002596 B6;129P2-Nos2tm1Lau/J 003243 B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J 003692 B6;129X1-Sncatm1Rosl/J 016575 B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J 016576 B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J 008169 B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J 004479 B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J 000231 B6;C3Fe a/a-Csf1op/J 012450 B6;D2-Tg(tetO-SNCA)1Cai/J 013725 B6;SJL-Tg(LRRK2)66Mjff/J 016555 B6;SJL-Tg(Nqo1-ALPP)1Jaj/J 008473 B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J 008134 B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J 016976 B6C3-Tg(tetO-SNCA*A53T)33Vle/J 000506 B6C3Fe a/a-Qkqk-v/J 003741 B6D2-Tg(Prnp-MAPT)43Vle/J 018768 B6N.Cg-Tg(SNCA*E46K)3Elan/J 012621 C.129S(B6)-Chrna3tm1.1Hwrt/J 016120 C57BL/6-Lrrk1tm1.1Mjff/J 012444 C57BL/6-Lrrk2tm1Mjfa/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J 012769 C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J 005706 C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 008245 C57BL/6J-Tg(Th-SNCA)5Eric/J 008239 C57BL/6J-Tg(Th-SNCA*A30P*A53T)39Eric/J 016122 C57BL/6N-Lrrk1tm1.1Mjff Lrrk2tm1.1Mjff/J 016121 C57BL/6N-Lrrk2tm1.1Mjff/J 016123 C57BL/6N-Sncatm1Mjff/J 016936 C57BL/6N-Tg(Thy1-SNCA)12Mjff/J 017682 C57BL/6N-Tg(Thy1-SNCA)15Mjff/J 007677 CB6-Tg(Gad1-EGFP)G42Zjh/J 009610 FVB/N-Tg(LRRK2)1Cjli/J 009609 FVB/N-Tg(LRRK2*G2019S)1Cjli/J 009604 FVB/N-Tg(LRRK2*R1441G)135Cjli/J 009090 FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy/J 017678 FVB;129-Pink1tm1Aub Tg(Prnp-SNCA*A53T)AAub/J 017744 FVB;129-Tg(Prnp-SNCA*A53T)AAub/J 010710 FVB;129S6-Sncatm1Nbm Tg(SNCA)1Nbm/J 010788 FVB;129S6-Sncatm1Nbm Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/J 010799 FVB;129S6-Sncatm1Nbm Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/J 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 000942 STOCK Pitx3ak/2J 014092 STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J 006340 STOCK Tg(Gad1-EGFP)98Agmo/J 017000 STOCK Tg(SNCA*E46K)3Elan/J 008474 STOCK Tg(THY1-SNCA*A53T)F53Sud/J 008132 STOCK Tg(THY1-Snca)M1mSud/J 012441 STOCK Tg(tetO-LRRK2*G2019S)E3Cai/J 012442 STOCK Tg(tetO-SNCA*A53T)E2Cai/J 012449 STOCK Tg(teto-LRRK2)C7874Cai/J View Parkinson's Disease Models (109 strains)
Strains carrying other alleles of Chat
016920 B6.129-Chattm1Jrs/J 014545 B6.Cg-Tg(Chat-COP4*H134R/EYFP)5Gfng/J 014546 B6.Cg-Tg(Chat-COP4*H134R/EYFP)6Gfng/J 007902 B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J 006410 B6;129S6-Chattm2(cre)Lowl/J View Strains carrying other alleles of Chat (5 strains)
Strains carrying other alleles of cre
004337 129(Cg)-Foxg1tm1(cre)Skm/J 008569 129-Alpltm1(cre)Nagy/J 017611 129-Mcm2tm1(cre/ERT2)Scpr/J 005989 129;FVB-Tg(PTH-cre)4167Slib/J 007179 129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J 007915 129S.FVB-Tg(Amh-cre)8815Reb/J 003328 129S/Sv-Tg(Prm-cre)58Og/J 004302 129S1/Sv-Hprttm1(cre)Mnn/J 003960 129S6-Tg(Prnp-GFP/cre)1Blw/J 008523 129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ 009575 B6(129S4)-Et(cre/ERT2)119Rdav/J 009580 B6(129S4)-Et(cre/ERT2)1382Rdav/J 012688 B6(129S4)-Et(cre/ERT2)13866Rdav/J 009581 B6(129S4)-Et(cre/ERT2)1642Rdav/J 009582 B6(129S4)-Et(cre/ERT2)1645Rdav/J 009583 B6(129S4)-Et(cre/ERT2)1957Rdav/J 009584 B6(129S4)-Et(cre/ERT2)2007Rdav/J 009585 B6(129S4)-Et(cre/ERT2)2047Rdav/J 009574 B6(129S4)-Et(cre/ERT2)21Rdav/J 009577 B6(129S4)-Et(cre/ERT2)296Rdav/J 009578 B6(129S4)-Et(cre/ERT2)398Rdav/J 009573 B6(129S4)-Et(cre/ERT2)4Rdav/J 010688 B6(129S4)-Et(cre/ERT2)6691Rdav/J 010689 B6(129S4)-Et(cre/ERT2)6959Rdav/J 010690 B6(129S4)-Et(cre/ERT2)7089Rdav/J 010691 B6(129S4)-Et(cre/ERT2)7149Rdav/J 010692 B6(129S4)-Et(cre/ERT2)7381Rdav/J 010693 B6(129S4)-Et(cre/ERT2)8120Rdav/J 010694 B6(129S4)-Et(cre/ERT2)8131Rdav/J 009579 B6(129S4)-Et(cre/ERT2)837Rdav/J 010695 B6(129S4)-Et(cre/ERT2)9699Rdav/J 009587 B6(129S4)-Et(icre)1402Rdav/J 009588 B6(129S4)-Et(icre)1470Rdav/J 009589 B6(129S4)-Et(icre)1555Rdav/J 009586 B6(129S4)-Et(icre)754Rdav/J 010696 B6(129S4)-Et(icre/ERT2)10596Rdav/J 010697 B6(129S4)-Et(icre/ERT2)10727Rdav/J 012689 B6(129S4)-Et(icre/ERT2)14163Rdav/J 012690 B6(129S4)-Et(icre/ERT2)14208Rdav/J 012694 B6(129S4)-Et(icre/ERT2)14915Rdav/J 012687 B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J 010774 B6(Cg)-Calb2tm1(cre)Zjh/J 013730 B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J 017562 B6(Cg)-Cd8atm1.1(cre)Koni/J 012704 B6(Cg)-Crhtm1(cre)Zjh/J 010705 B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J 013048 B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J 018448 B6(Cg)-Foxn1tm3(cre)Nrm/J 010776 B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J 010777 B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J 010708 B6(Cg)-Ssttm1(cre/ERT2)Zjh/J 016223 B6(Cg)-Tg(Phox2b-cre)3Jke/J 016829 B6(SJL)-Pou5f1tm1.1(cre/Esr1*)Yseg/J 018867 B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J 016959 B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J 008463 B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J 008320 B6.129-Leprtm2(cre)Rck/J 017526 B6.129-Nos1tm1(cre)Mgmj/J 005697 B6.129-Otx1tm4(cre)Asim/J 018938 B6.129-Tac2tm1.1(cre)Qima/J 017769 B6.129-Trpv1tm1(cre)Bbm/J 004146 B6.129-Tg(Pcp2-cre)2Mpin/J 008710 B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax 008877 B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax 009116 B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax 008709 B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax 006785 B6.129P2(C)-Cd19tm1(cre)Cgn/J 021160 B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ 006084 B6.129P2(Cg)-Foxg1tm1(cre)Skm/J 010611 B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J 008875 B6.129P2-Lgr5tm1(cre/ERT2)Cle/J 016934 B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J 004781 B6.129P2-Lyz2tm1(cre)Ifo/J 016222 B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ 013594 B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J 006600 B6.129S1-Mnx1tm4(cre)Tmj/J 005628 B6.129S2-Emx1tm1(cre)Krj/J 017578 B6.129S4-Mcpt8tm1(cre)Lky/J 003755 B6.129S4-Meox2tm1(cre)Sor/J 007893 B6.129S4-Myf5tm3(cre)Sor/J 019378 B6.129S6(Cg)-Ptf1atm2(cre/ESR1)Cvw/J 005623 B6.129S6-Shhtm2(cre/ERT2)Cjt/J 006878 B6.129S6-Taglntm2(cre)Yec/J 012839 B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J 008712 B6.129X1-Twist2tm1.1(cre)Dor/J 006054 B6.C-Tg(CMV-cre)1Cgn/J 009642 B6.Cg(129)-Tg(Gh1-cre)1Sac/J 013590 B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ 006230 B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J 012360 B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J 017763 B6.Cg-Pax7tm1(cre/ERT2)Gaka/J 012358 B6.Cg-Pvalbtm1.1(cre)Aibs/J 005622 B6.Cg-Shhtm1(EGFP/cre)Cjt/J 017346 B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J 006149 B6.Cg-Tg(ACTA1-cre)79Jme/J 003574 B6.Cg-Tg(Alb-cre)21Mgn/J 006881 B6.Cg-Tg(Aqp2-cre)1Dek/J 011104 B6.Cg-Tg(Atoh1-cre)1Bfri/J 004682 B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J 008520 B6.Cg-Tg(CD2-cre)4Kio/J 009350 B6.Cg-Tg(CDX2-cre)101Erf/J 009352 B6.Cg-Tg(CDX2-cre*)189Erf/J 005359 B6.Cg-Tg(Camk2a-cre)T29-1Stl/J 012237 B6.Cg-Tg(Cdh16-cre)91Igr/J 006137 B6.Cg-Tg(Cdh5-cre)7Mlia/J 016241 B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J 016237 B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J 006368 B6.Cg-Tg(Cr2-cre)3Cgn/J 008538 B6.Cg-Tg(Cspg4-cre/Esr1*)BAkik/J 006663 B6.Cg-Tg(Eno2-cre)39Jme/J 005069 B6.Cg-Tg(Fabp4-cre)1Rev/J 012712 B6.Cg-Tg(Fev-cre)1Esd/J 012849 B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J 012886 B6.Cg-Tg(Gfap-cre)73.12Mvs/J 012887 B6.Cg-Tg(Gfap-cre)77.6Mvs/J 003573 B6.Cg-Tg(Ins2-cre)25Mgn/J 008068 B6.Cg-Tg(Itgax-cre)1-1Reiz/J 008781 B6.Cg-Tg(Kap-cre)29066/2Sig/J 012837 B6.Cg-Tg(Lck-cre)3779Nik/J 003802 B6.Cg-Tg(Lck-cre)548Jxm/J 006889 B6.Cg-Tg(Lck-cre)I540Jxm/J 009643 B6.Cg-Tg(Lhb-cre)1Sac/J 003556 B6.Cg-Tg(Mx1-cre)1Cgn/J 007742 B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J 008205 B6.Cg-Tg(NPHS2-cre)295Lbh/J 003771 B6.Cg-Tg(Nes-cre)1Kln/J 010536 B6.Cg-Tg(Pcp2-cre)3555Jdhu/J 005975 B6.Cg-Tg(Plp1-cre/ERT)3Pop/J 008827 B6.Cg-Tg(Prdm1-cre)1Masu/J 005584 B6.Cg-Tg(Prrx1-cre)1Cjt/J 003967 B6.Cg-Tg(Rbp3-cre)528Jxm/J 021614 B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J 008454 B6.Cg-Tg(Sox2-cre)1Amc/J 006361 B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J 003966 B6.Cg-Tg(Syn1-cre)671Jxm/J 017491 B6.Cg-Tg(Tagln-cre)1Her/J 004128 B6.Cg-Tg(Tek-cre)12Flv/J 008863 B6.Cg-Tg(Tek-cre)1Ywa/J 008601 B6.Cg-Tg(Th-cre)1Tmd/J 007606 B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J 012328 B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J 008085 B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J 008610 B6.Cg-Tg(Vav1-cre)A2Kio/J 008735 B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ 009614 B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J 009107 B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J 006234 B6.Cg-Tg(tetO-cre)1Jaw/J 016832 B6.FVB(129)-Tg(Alb1-cre)1Dlr/J 005657 B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J 006475 B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J 018422 B6.FVB(129X1)-Tg(Aicda-cre)1Rcas/J 006451 B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J 006333 B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J 014643 B6.FVB-Tg(CMA1-cre)6Thhe/J 011087 B6.FVB-Tg(Crh-cre)1Kres/J 003724 B6.FVB-Tg(EIIa-cre)C5379Lmgd/J 011069 B6.FVB-Tg(Gh1-cre)bKnmn/J 014647 B6.FVB-Tg(Ipfl-cre)6Tuv/J 011038 B6.FVB-Tg(Myh6-cre)2182Mds/J 010714 B6.FVB-Tg(Pomc-cre)1Stl/J 017535 B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ 017490 B6.FVB-Tg(Stra8-cre)1Reb/LguJ 003394 B6.FVB-Tg(Zp3-cre)3Mrt/J 014579 B6.NOD-Tg(Foxp3-EGFP/cre)1aJbs/J 006660 B6.SJL-Slc6a3tm1.1(cre)Bkmn/J 004586 B6.SJL-Tg(Vil-cre)997Gum/J 003552 B6129-Tg(Wap-cre)11738Mam/J 010531 B6;129-Bmi1tm1(cre/ERT)Mrc/J 004847 B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J 010557 B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J 010529 B6;129-Myf5tm1(cre)Mrc/J 010528 B6;129-Myf6tm2(cre)Mrc/J 008363 B6;129-Nefltm1(cre/ERT)Nat/J 017525 B6;129-Ntstm1(cre)Mgmj/J 005549 B6;129-Pax3tm1(cre)Joe/J 012476 B6;129-Pax7tm2.1(cre/ERT2)Fan/J 009600 B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J 008532 B6;129-Thtm1(cre/Esr1)Nat/J 008531 B6;129-Vamp2tm1(cre/ERT)Nat/J 017968 B6;129-Tg(Cdh5-cre)1Spe/J 010988 B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J 010985 B6;129P-Klf3tm1(cre/ERT2)Pzg/J 008529 B6;129P-Tg(Neurog1-cre/ERT2)1Good/J 007770 B6;129P2-Aicdatm1(cre)Mnz/J 015854 B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J 012601 B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J 006668 B6;129P2-Omptm4(cre)Mom/MomJ 008069 B6;129P2-Pvalbtm1(cre)Arbr/J 012373 B6;129S-Hoxb1tm1(cre)Og/J 014541 B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J 010987 B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J 017593 B6;129S-Sox2tm1(cre/ERT2)Hoch/J 017685 B6;129S-Wisp3tm1(cre)Mawa/J 007001 B6;129S-Tg(UBC-cre/ERT2)1Ejb/J 009388 B6;129S1-Osr2tm2(cre)Jian/J 014551 B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J 012463 B6;129S4-Foxd1tm1(GFP/cre)Amc/J 012464 B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J 011105 B6;129S4-Olig1tm1(cre)Rth/J 009576 B6;129S4-Et(cre/ERT2)278Rdav/J 006410 B6;129S6-Chattm2(cre)Lowl/J 012362 B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J 017495 B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J 014638 B6;129X1-Cldn6tm1(cre/ERT2)Dam/J 009616 B6;C3-Tg(A930038C07Rik-cre)4Aibs/J 012433 B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J 008844 B6;C3-Tg(Ctgf-cre)2Aibs/J 008839 B6;C3-Tg(Cyp39a1-cre)1Aibs/J 009117 B6;C3-Tg(Cyp39a1-cre)7Aibs/J 008848 B6;C3-Tg(Mybpc1-cre)2Aibs/J 009111 B6;C3-Tg(Scnn1a-cre)1Aibs/J 009112 B6;C3-Tg(Scnn1a-cre)2Aibs/J 009613 B6;C3-Tg(Scnn1a-cre)3Aibs/J 009103 B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J 017494 B6;D-Tg(Tshz3-GFP/cre)43Amc/J 003466 B6;D2-Tg(Sycp1-cre)4Min/J 014160 B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J 014159 B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J 015855 B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J 010803 B6;FVB-Tg(Adipoq-cre)1Evdr/J 008533 B6;FVB-Tg(Cspg4-cre)1Akik/J 003734 B6;FVB-Tg(GZMB-cre)1Jcb/J 004426 B6;SJL-Tg(Cga-cre)3Sac/J 003554 B6;SJL-Tg(Col2a1-cre)1Bhr/J 017738 B6;SJL-Tg(Foxl1-cre)1Khk/J 005249 B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J 007610 B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J 007252 B6Ei.129S4-Tg(Prm-cre)58Og/EiJ 016225 B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J 017310 B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J 014094 B6N.Cg-Tg(Sox2-cre)1Amc/J 019509 B6N.FVB-Tg(BGLAP-cre)1Clem/J 017927 B6N.FVB-Tg(Mpz-cre)26Mes/J 010550 B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J 017743 B6N;129S-Prom1tm1(cre/ERT2)Gilb/J 003465 BALB/c-Tg(CMV-cre)1Cgn/J 012641 BALB/c-Tg(S100a4-cre)1Egn/YunkJ 010612 C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J 017353 C.129S4(B6)-Il13tm1(YFP/cre)Lky/J 017582 C.129S4(B6)-Mcpt8tm1(cre)Lky/J 004126 C.Cg-Cd19tm1(cre)Cgn Ighb/J 005673 C.Cg-Tg(Mx1-cre)1Cgn/J 006244 C.Cg-Tg(tetO-cre)1Jaw/J 009155 C57BL/6-Cldn6tm1(cre)Dkwu/J 017557 C57BL/6-Tg(BEST1-cre)1Jdun/J 016097 C57BL/6-Tg(Car1-cre)5Flt/J 011086 C57BL/6-Tg(Cck-cre)CKres/J 008766 C57BL/6-Tg(Cd8a-cre)1Itan/J 006474 C57BL/6-Tg(Grik4-cre)G32-4Stl/J 008314 C57BL/6-Tg(HBB-cre)12Kpe/J 008870 C57BL/6-Tg(Hspa2-cre)1Eddy/J 016261 C57BL/6-Tg(Nes-cre/ERT2)KEisc/J 012906 C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J 016617 C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J 020287 C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J 013148 C57BL/6-Tg(Pdgfra-cre)1Clc/J 008535 C57BL/6-Tg(Pf4-cre)Q3Rsko/J 006888 C57BL/6-Tg(Zp3-cre)1Gwh/J 003651 C57BL/6-Tg(Zp3-cre)93Knw/J 007567 C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J 021582 C57BL/6J-Tg(Mchr1-cre)1Emf/J 008661 C57BL/6J-Tg(Nkx2-1-cre)2Sand/J 003650 C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ 018151 C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ 012686 C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J 016582 C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J 016583 C57BL/6N-Tg(Slc6a3-icre/ERT2)2Gloss/J 016833 FVB(Cg)-Tg(Alb1-cre)1Dlr/J 012929 FVB(Cg)-Tg(Dhh-cre)1Mejr/J 011034 FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J 006405 FVB-Tg(Ckmm-cre)5Khn/J 006774 FVB-Tg(Col2a1-cre/ERT)KA3Smac/J 021024 FVB-Tg(Csf1r-icre)1Jwp/J 006954 FVB-Tg(Ddx4-cre)1Dcas/J 004600 FVB-Tg(GFAP-cre)25Mes/J 011037 FVB-Tg(Myh6-cre)2182Mds/J 006364 FVB-Tg(Nr5a1-cre)2Lowl/J 008537 FVB-Tg(Tek-cre)2352Rwng/J 014140 FVB.Cg-Myod1tm2.1(icre)Glh/J 006139 FVB.Cg-Tg(ACTA1-cre)79Jme/J 017595 FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J 006297 FVB.Cg-Tg(Eno2-cre)39Jme/J 018394 FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ 008244 FVB.Cg-Tg(tetO-cre)1Jaw/J 003376 FVB/N-Tg(ACTB-cre)2Mrt/J 003314 FVB/N-Tg(EIIa-cre)C5379Lmgd/J 017928 FVB/N-Tg(Mpz-cre)26Mes/J 006143 FVB/N-Tg(Thy1-cre)1Vln/J 003377 FVB/N-Tg(Zp3-cre)3Mrt/J 019096 NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ 013233 NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J 013234 NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ 005732 NOD.Cg-Tg(Lck-cre)548Jxm/AchJ 013251 NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J 008694 NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J 004986 NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ 003855 NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ 004987 NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ 012899 STOCK Agrptm1(cre)Lowl/J 012882 STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J 012706 STOCK Ccktm1.1(cre)Zjh/J 012710 STOCK Ccktm2.1(cre/ERT2)Zjh/J 010910 STOCK Corttm1(cre)Zjh/J 007916 STOCK En1tm2(cre)Wrst/J 007917 STOCK En1tm7(cre/ESR1)Alj/J 007924 STOCK En2tm4(cre/ERT2)Alj/J 008464 STOCK Foxa2tm2.1(cre/Esr1*)Moon/J 016961 STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J 010702 STOCK Gad2tm1(cre/ERT2)Zjh/J 010802 STOCK Gad2tm2(cre)Zjh/J 007913 STOCK Gli1tm3(cre/ERT2)Alj/J 018903 STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J 017606 STOCK Hopxtm2.1(cre/ERT2)Joe/J 008876 STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax 016879 STOCK Il17atm1.1(icre)Stck/J 018976 STOCK Kdrtm1(cre)Sato/J 017701 STOCK Kiss1tm1.1(cre/EGFP)Stei/J 007022 STOCK Mnx1tm4(cre)Tmj Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J 004192 STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J 014180 STOCK Myocdtm1(cre)Jomm/J 014552 STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J 017536 STOCK Nkx6-2tm1(cre/ERT2)Fsh/J 006953 STOCK Notch1tm3(cre)Rko/J 006677 STOCK Olfr151tm28(cre)Mom/MomJ 011103 STOCK Olig2tm2(TVA,cre)Rth/J 009061 STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J 010530 STOCK Pax7tm1(cre)Mrc/J 017569 STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J 017585 STOCK Polr2atm1(cre/ERT2)Bbd/J 016963 STOCK Slc17a6tm2(cre)Lowl/J 016962 STOCK Slc32a1tm2(cre)Lowl/J 008783 STOCK Smn1tm3(SMN2/Smn1)Mrph Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Tg(CAG-cre/Esr1*)5Amc/J 013044 STOCK Ssttm2.1(cre)Zjh/J 019508 STOCK Tcf21tm3.1(cre/Esr1*)Eno/J 012719 STOCK Tgfb3tm1(cre)Vk/J 012620 STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J 008813 STOCK Trpa1tm2Kykw Tg(CAG-cre/Esr1*)5Amc/J 010908 STOCK Viptm1(cre)Zjh/J 010911 STOCK Wt1tm1(EGFP/cre)Wtp/J 010912 STOCK Wt1tm2(cre/ERT2)Wtp/J 012691 STOCK Et(icre/ERT2)14374Rdav/J 012692 STOCK Et(icre/ERT2)14602Rdav/J 012693 STOCK Et(icre/ERT2)14624Rdav/J 007684 STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J 004453 STOCK Tg(CAG-cre/Esr1*)5Amc/J 009615 STOCK Tg(Cartpt-cre)1Aibs/J 017336 STOCK Tg(Cd4-cre)1Cwi/BfluJ 005105 STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J 008861 STOCK Tg(Ela1-Cre/ERT2)1Stof/J 008852 STOCK Tg(En2-cre)22Alj/J 005938 STOCK Tg(Eno2-cre)39Jme/J 011062 STOCK Tg(Gdf9-cre)5092Coo/J 012841 STOCK Tg(Ggt1-cre)M3Egn/J 021207 STOCK Tg(Gnrh1-cre)1Dlc/J 017981 STOCK Tg(Hoxb6-cre)Mku/J 004692 STOCK Tg(Hoxb7-cre)13Amc/J 014600 STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J 008122 STOCK Tg(Ins2-cre/ERT)1Dam/J 004782 STOCK Tg(KRT14-cre)1Amc/J 005107 STOCK Tg(KRT14-cre/ERT)20Efu/J 008582 STOCK Tg(Kcnc2-Cre)K128Stl/LetJ 017836 STOCK Tg(LGB-cre)74Acl/J 003551 STOCK Tg(MMTV-cre)1Mam/J 003553 STOCK Tg(MMTV-cre)4Mam/J 002527 STOCK Tg(Mx1-cre)1Cgn/J 009074 STOCK Tg(Myh6-cre)1Jmk/J 005650 STOCK Tg(Myh6-cre/Esr1*)1Jmk/J 009102 STOCK Tg(Nefh-cre)12Kul/J 002858 STOCK Tg(Nes-cre)1Wme/J 002859 STOCK Tg(Nes-cre)2Wme/J 012859 STOCK Tg(Neurog1-cre)1Jejo/J 005667 STOCK Tg(Neurog3-cre)C1Able/J 008119 STOCK Tg(Neurog3-cre/Esr1*)1Dam/J 012462 STOCK Tg(Nr5a1-cre)7Lowl/J 014158 STOCK Tg(Pax4-cre)1Dam/J 006207 STOCK Tg(Pcp2-cre)1Amc/J 014099 STOCK Tg(Pmch-cre)1Lowl/J 005965 STOCK Tg(Pomc1-cre)16Lowl/J 012452 STOCK Tg(Rr5-GFP/cre)1Sapc/J 006395 STOCK Tg(Sim1-cre)1Lowl/J 009606 STOCK Tg(Six2-EGFP/cre)1Amc/J 018147 STOCK Tg(Slc17a8-icre)1Edw/SealJ 012586 STOCK Tg(Slc1a3-cre/ERT)1Nat/J 004783 STOCK Tg(Sox2-cre)1Amc/J 008208 STOCK Tg(Stra8-cre)1Reb/J 016236 STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J 004746 STOCK Tg(Tagln-cre)1Her/J 012708 STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ 016584 STOCK Tg(Tph2-icre/ERT2)6Gloss/J 003829 STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J 008851 STOCK Tg(Wnt1-cre/ERT)1Alj/J 008199 STOCK Tg(dlx6a-cre)1Mekk/J 002471 STOCK Tg(hCMV-cre)140Sau/J 006224 STOCK Tg(tetO-cre)1Jaw/J View Strains carrying other alleles of cre (394 strains)
Introduction to Cre-lox technology
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.
View Related Disease (OMIM) Terms
Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Myasthenic Syndrome, Congenital, Associated with Episodic Apnea (CHAT)
View Mammalian Phenotype Terms
Mammalian Phenotype Terms provided by MGI
assigned by genotype
Chattm1(cre/ERT)Nat/Chattm1(cre/ERT)Nat
involves: 129 * C57BL/6
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:144315)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Alzheimer's Disease
Cre-lox System
Cre Recombinase expression in neural tissue
Parkinson's Disease
strains expressing cre
Research Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Inducible
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
| Allele Symbol | Chattm1(cre/ERT)Nat | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Jeremy Nathans | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | ChAT-IRES-creER(T); Chattm1(cre/Esr1)Nat; | ||
| Strain of Origin | 129 | ||
| ES Cell Line Name | Other (see notes) | ||
| ES Cell Line Strain | 129 | ||
| Site of Expression | cholinergic neurons (after induction) | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Chat | ||
| General Note | ES cell line = JHMI-ES1. | ||
| Inducible Note | Induced by tamoxifen. | ||
| Molecular Note | An IRES-creER cassette, a tetracycline resistance gene, and a Frt-flanked neomycin selection marker were all knocked in to the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in amacrine cells of the retina, and in a sparse number of cholinergic neurons in the brain. [MGI Ref ID J:144315] | ||
| Gene Symbol and Name | Chat, choline acetyltransferase | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | B230380D24Rik; CHOACTASE; CMS1A; CMS1A2; RIKEN cDNA B230380D24 gene; | ||
Genotyping Protocols
Chattm1(cre/ERT)Nat, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
Rotolo T; Smallwood PM; Williams J; Nathans J. 2008. Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS ONE 3(12):e4099. [PubMed: 19116659] [MGI Ref ID J:144315]
Chattm1(cre/ERT)Nat relatedArteaga-Solis E; Zee T; Emala CW; Vinson C; Wess J; Karsenty G. 2013. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab 17(1):35-48. [PubMed: 23312282] [MGI Ref ID J:195073]
Badea TC; Hua ZL; Smallwood PM; Williams J; Rotolo T; Ye X; Nathans J. 2009. New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling. PLoS One 4(11):e7859. [PubMed: 19924248] [MGI Ref ID J:155417]
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry When maintained as a live colony, heterozygotes or homozygotes may be bred.
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
| Control | ||
|---|---|---|
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
For Licensing and Use Restrictions view the link(s) below:
- Mice are subject to US Patent 6040430.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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