Strain Name:

B6.129S1-Tlr7tm1Flv/J

Stock Number:

008380

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Availability:

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Use Restrictions Apply, see Terms of Use
These toll-like receptor 7 (Tlr7) targeted mutation mice may be useful in studies of viral immunity. Homozygotes demonstrate reduced responses to in vivo infection with vesicular stomatitis virus. The lacZ reporter introduced under the gene's promoter shows that within mesenteric lymph nodes, expression is normally confined to the perifollicular regions.

Description

Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Hemizygote         (Female x Male)   06-DEC-11
Specieslaboratory mouse
GenerationN10+F12 (03-JUN-14)
Generation Definitions
 
Donating InvestigatorDr. Richard A. Flavell,   Yale University School of Medicine

Description
These toll-like receptor 7 targeted mutation mice may be useful in studies of viral immunity. Homozygotes demonstrate reduced responses to in vivo infection with vesicular stomatitis virus. This emphasizes the roll of the gene in viral recognition by plasmacytoid dendritic cells and B cells which activate costimulatory molecules and produce cytokines. No RNA expression is detected in bone marrow-derived macrophages by Northern blot analysis. The lacZ reporter introduced under the gene's promoter shows that within mesenteric lymph nodes, expression is normally confined to the perifollicular regions. Homozygotes are viable, fertile, have no obvious developmental problems, but are poor breeders for unknown reasons.

Development
A segment of exon 3 was replaced by a lacZ gene and loxP-flanked neomycin resistance cassette. The targeting vector was introduced to 129S1/Sv-p+ Tyr+ Kitl+-derived CJ7 embryonic stem (ES) cells. This line was backcrossed ten times to C57BL/6Ncr by the donating laboratory. Upon arrival at The Jackson Laboratory, this strain was crossed one time to C57BL/6J.

Control Information

  Control
   005304 C57BL/6NJ (approximate)
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tlr7tm1Flv/Tlr7tm1Flv

        B6.129S1-Tlr7tm1Flv
  • immune system phenotype
  • decreased IgG level
    • in the serum and as glomerular deposition   (MGI Ref ID J:165267)
    • decreased IgG1 level   (MGI Ref ID J:165267)
    • decreased IgG2a level   (MGI Ref ID J:165267)
  • decreased IgM level
    • in the serum and as glomerular deposition   (MGI Ref ID J:165267)
  • decreased anti-insulin autoantibody level   (MGI Ref ID J:165267)
  • hematopoietic system phenotype
  • decreased IgG level
    • in the serum and as glomerular deposition   (MGI Ref ID J:165267)
    • decreased IgG1 level   (MGI Ref ID J:165267)
    • decreased IgG2a level   (MGI Ref ID J:165267)
  • decreased IgM level
    • in the serum and as glomerular deposition   (MGI Ref ID J:165267)

Tlr7tm1Flv/Y

        B6.129S1-Tlr7tm1Flv
  • immune system phenotype
  • decreased splenocyte proliferation
    • absence of the splenocyte proliferation response to imiquimod   (MGI Ref ID J:127600)
  • increased marginal zone B cell number
    • slight increase   (MGI Ref ID J:127600)
  • hematopoietic system phenotype
  • decreased splenocyte proliferation
    • absence of the splenocyte proliferation response to imiquimod   (MGI Ref ID J:127600)
  • increased marginal zone B cell number
    • slight increase   (MGI Ref ID J:127600)
  • cellular phenotype
  • decreased splenocyte proliferation
    • absence of the splenocyte proliferation response to imiquimod   (MGI Ref ID J:127600)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tlr7tm1Flv/Tlr7tm1Flv

        involves: 129S1/Sv
  • immune system phenotype
  • decreased circulating interferon-alpha level
    • while IFNalpha secretion in response to infection with vesicular stomatitis virus (a ssRNA virus) was similar to controls, serum levels of IFNalpha were reduced after infection relative to controls   (MGI Ref ID J:89257)
  • homeostasis/metabolism phenotype
  • decreased circulating interferon-alpha level
    • while IFNalpha secretion in response to infection with vesicular stomatitis virus (a ssRNA virus) was similar to controls, serum levels of IFNalpha were reduced after infection relative to controls   (MGI Ref ID J:89257)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
      genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency
      Tlr deficiency
Inflammation
      Tlr deficiency

Virology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tlr7tm1Flv
Allele Name targeted mutation 1, Richard A Flavell
Allele Type Targeted (Null/Knockout, Reporter)
Common Name(s) Tlr7-;
Mutation Made ByDr. Richard Flavell,   Yale University School of Medicine
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameCJ7
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Tlr7, toll-like receptor 7
Chromosome X
Gene Common Name(s) RGD1563357; TLR7-like;
Molecular Note A cassette containing lacZ and floxed neo replaced a portion of exon 3. Northern blot analysis of mutant bone marrow-derived macrophages indicated no mRNA was present. Beta galactose staining showed expression of lacZ in mutant lymph nodes. [MGI Ref ID J:102090] [MGI Ref ID J:89257]

Genotyping

Genotyping Information

Genotyping Protocols

Tlr7tm1Flv, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Lund JM; Alexopoulou L; Sato A; Karow M; Adams NC; Gale NW; Iwasaki A; Flavell RA. 2004. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A 101(15):5598-603. [PubMed: 15034168]  [MGI Ref ID J:89257]

Additional References

Tlr7tm1Flv related

Browne EP. 2013. Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses. J Virol 87(13):7357-66. [PubMed: 23616654]  [MGI Ref ID J:198442]

Browne EP. 2011. Toll-like receptor 7 controls the anti-retroviral germinal center response. PLoS Pathog 7(10):e1002293. [PubMed: 21998589]  [MGI Ref ID J:183184]

Buechler MB; Teal TH; Elkon KB; Hamerman JA. 2013. Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling. J Immunol 190(3):886-91. [PubMed: 23303674]  [MGI Ref ID J:193249]

Chen A; Ahlen G; Brenndorfer ED; Brass A; Holmstrom F; Chen M; Soderholm J; Milich DR; Frelin L; Sallberg M. 2011. Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination. J Immunol 186(9):5107-18. [PubMed: 21430225]  [MGI Ref ID J:172864]

Christensen SR; Shupe J; Nickerson K; Kashgarian M; Flavell RA; Shlomchik MJ. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25(3):417-28. [PubMed: 16973389]  [MGI Ref ID J:113557]

Clingan JM; Matloubian M. 2013. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol 191(2):810-8. [PubMed: 23761632]  [MGI Ref ID J:204821]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Demaria O; Pagni PP; Traub S; de Gassart A; Branzk N; Murphy AJ; Valenzuela DM; Yancopoulos GD; Flavell RA; Alexopoulou L. 2010. TLR8 deficiency leads to autoimmunity in mice. J Clin Invest 120(10):3651-62. [PubMed: 20811154]  [MGI Ref ID J:165267]

Fabbri M; Paone A; Calore F; Galli R; Gaudio E; Santhanam R; Lovat F; Fadda P; Mao C; Nuovo GJ; Zanesi N; Crawford M; Ozer GH; Wernicke D; Alder H; Caligiuri MA; Nana-Sinkam P; Perrotti D; Croce CM. 2012. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 109(31):E2110-6. [PubMed: 22753494]  [MGI Ref ID J:188409]

Gregorio J; Meller S; Conrad C; Di Nardo A; Homey B; Lauerma A; Arai N; Gallo RL; Digiovanni J; Gilliet M. 2010. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207(13):2921-30. [PubMed: 21115688]  [MGI Ref ID J:176867]

Herlands RA; Christensen SR; Sweet RA; Hershberg U; Shlomchik MJ. 2008. T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells. Immunity 29(2):249-60. [PubMed: 18691914]  [MGI Ref ID J:139567]

Ichinohe T; Pang IK; Iwasaki A. 2010. Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol 11(5):404-10. [PubMed: 20383149]  [MGI Ref ID J:158948]

Jeisy-Scott V; Davis WG; Patel JR; Bowzard JB; Shieh WJ; Zaki SR; Katz JM; Sambhara S. 2011. Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice. PLoS One 6(9):e25242. [PubMed: 21966467]  [MGI Ref ID J:177864]

Jeisy-Scott V; Kim JH; Davis WG; Cao W; Katz JM; Sambhara S. 2012. TLR7 Recognition Is Dispensable for Influenza Virus A Infection but Important for the Induction of Hemagglutinin-Specific Antibodies in Response to the 2009 Pandemic Split Vaccine in Mice. J Virol 86(20):10988-98. [PubMed: 22837197]  [MGI Ref ID J:187889]

Kolli D; Bao X; Liu T; Hong C; Wang T; Garofalo RP; Casola A. 2011. Human metapneumovirus glycoprotein G inhibits TLR4-dependent signaling in monocyte-derived dendritic cells. J Immunol 187(1):47-54. [PubMed: 21632720]  [MGI Ref ID J:176038]

Lamere MW; Lam HT; Moquin A; Haynes L; Lund FE; Randall TD; Kaminski DA. 2011. Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus. J Immunol 186(7):4331-9. [PubMed: 21357542]  [MGI Ref ID J:170689]

Lebel ME; Daudelin JF; Chartrand K; Tarrab E; Kalinke U; Savard P; Labrecque N; Leclerc D; Lamarre A. 2014. Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection. J Immunol 192(3):1071-8. [PubMed: 24376264]  [MGI Ref ID J:207307]

Liu T; Berta T; Xu ZZ; Park CK; Zhang L; Lu N; Liu Q; Liu Y; Gao YJ; Liu YC; Ma Q; Dong X; Ji RR. 2012. TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. J Clin Invest 122(6):2195-207. [PubMed: 22565312]  [MGI Ref ID J:188291]

Liu T; Xu ZZ; Park CK; Berta T; Ji RR. 2010. Toll-like receptor 7 mediates pruritus. Nat Neurosci 13(12):1460-2. [PubMed: 21037581]  [MGI Ref ID J:166905]

Neighbours LM; Long K; Whitmore AC; Heise MT. 2012. Myd88-dependent toll-like receptor 7 signaling mediates protection from severe ross river virus-induced disease in mice. J Virol 86(19):10675-85. [PubMed: 22837203]  [MGI Ref ID J:187888]

Nickerson KM; Christensen SR; Shupe J; Kashgarian M; Kim D; Elkon K; Shlomchik MJ. 2010. TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 184(4):1840-8. [PubMed: 20089701]  [MGI Ref ID J:159472]

Ochi A; Graffeo CS; Zambirinis CP; Rehman A; Hackman M; Fallon N; Barilla RM; Henning JR; Jamal M; Rao R; Greco S; Deutsch M; Medina-Zea MV; Bin Saeed U; Ego-Osuala MO; Hajdu C; Miller G. 2012. Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans. J Clin Invest 122(11):4118-29. [PubMed: 23023703]  [MGI Ref ID J:192739]

Oh JZ; Kurche JS; Burchill MA; Kedl RM. 2011. TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway. Blood 118(11):3028-38. [PubMed: 21813451]  [MGI Ref ID J:177064]

Pang IK; Ichinohe T; Iwasaki A. 2013. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nat Immunol 14(3):246-53. [PubMed: 23314004]  [MGI Ref ID J:193240]

Pang IK; Pillai PS; Iwasaki A. 2013. Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A 110(34):13910-5. [PubMed: 23918369]  [MGI Ref ID J:200675]

Park CK; Xu ZZ; Berta T; Han Q; Chen G; Liu XJ; Ji RR. 2014. Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron 82(1):47-54. [PubMed: 24698267]  [MGI Ref ID J:213160]

Parker D; Prince A. 2012. Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9. J Immunol 189(8):4040-6. [PubMed: 22962685]  [MGI Ref ID J:190532]

Sarvestani ST; Tate MD; Moffat JM; Jacobi AM; Behlke MA; Miller AR; Beckham SA; McCoy CE; Chen W; Mintern JD; O'Keeffe M; John M; Williams BR; Gantier MP. 2014. Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8. J Virol 88(2):799-810. [PubMed: 24227841]  [MGI Ref ID J:205285]

Seo YJ; Pritzl CJ; Vijayan M; Blake CR; McClain ME; Hahm B. 2012. Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways. J Immunol 188(10):4759-68. [PubMed: 22490865]  [MGI Ref ID J:188687]

Town T; Bai F; Wang T; Kaplan AT; Qian F; Montgomery RR; Anderson JF; Flavell RA; Fikrig E. 2009. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 30(2):242-53. [PubMed: 19200759]  [MGI Ref ID J:146461]

Traub S; Demaria O; Chasson L; Serra F; Desnues B; Alexopoulou L. 2012. Sex bias in susceptibility to MCMV infection: implication of TLR9. PLoS One 7(9):e45171. [PubMed: 23028824]  [MGI Ref ID J:192006]

Valenzuela DM; Murphy AJ; Frendewey D; Gale NW; Economides AN; Auerbach W; Poueymirou WT; Adams NC; Rojas J; Yasenchak J; Chernomorsky R; Boucher M; Elsasser AL; Esau L; Zheng J; Griffiths JA; Wang X; Su H; Xue Y; Dominguez MG; Noguera I; Torres R; Macdonald LE; Stewart AF; DeChiara TM; Yancopoulos GD. 2003. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21(6):652-9. [PubMed: 12730667]  [MGI Ref ID J:102090]

Volpi C; Fallarino F; Bianchi R; Orabona C; De Luca A; Vacca C; Romani L; Gran B; Grohmann U; Puccetti P; Belladonna ML. 2012. A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression. J Immunol 189(5):2283-9. [PubMed: 22844124]  [MGI Ref ID J:189860]

Wei J; Waithman J; Lata R; Mifsud NA; Cebon J; Kay T; Smyth MJ; Sadler AJ; Chen W. 2010. Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion. J Immunol 185(10):6013-22. [PubMed: 20956347]  [MGI Ref ID J:165777]

Weiss G; Maaetoft-Udsen K; Stifter SA; Hertzog P; Goriely S; Thomsen AR; Paludan SR; Frokiaer H. 2012. MyD88 drives the IFN-beta response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7. J Immunol 189(6):2860-8. [PubMed: 22896628]  [MGI Ref ID J:189947]

Zangi L; Klionsky YZ; Yarimi L; Bachar-Lustig E; Eidelstein Y; Shezen E; Hagin D; Ito Y; Takai T; Reich-Zeliger S; Lask A; Milstein O; Jung S; Shinder V; Reisner Y. 2012. Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7. Blood 120(8):1647-57. [PubMed: 22776817]  [MGI Ref ID J:189175]

Zucchini N; Bessou G; Traub S; Robbins SH; Uematsu S; Akira S; Alexopoulou L; Dalod M. 2008. Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J Immunol 180(9):5799-803. [PubMed: 18424698]  [MGI Ref ID J:134322]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Breeding & HusbandryWhen maintained as a live colony, homozygotes may be bred with hemizygotes (X linked).
Mating SystemHomozygote x Hemizygote         (Female x Male)   06-DEC-11

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00MaleHemizygous for Tlr7tm1Flv  
$232.00FemaleHomozygous for Tlr7tm1Flv  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Tlr7tm1Flv x Hemizygous for Tlr7tm1Flv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60MaleHemizygous for Tlr7tm1Flv  
$301.60FemaleHomozygous for Tlr7tm1Flv  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Tlr7tm1Flv x Hemizygous for Tlr7tm1Flv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   005304 C57BL/6NJ (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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