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| These CX3CR1-GFP mice express EGFP under control of the endogenous Cx3cr1 locus and also harbor the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background and may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies with C57BL/6 (CD45.2: Ptprcb) mice. | |||||||||||||||||||
- Description
- Phenotype
- Genes & alleles
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Description
Strain Information
Type Congenic; Mutant Strain; Spontaneous Mutation; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 18-JUL-08 Species laboratory mouse Generation N10+N1F9 (11-NOV-08)
Generation DefinitionsDonating Investigator Dan Littman, New York University Medical Center Description
Mice that are homozygous for the CX3CR1-GFP targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. RT-PCR analysis of lymphoid tissue from homozygotes detects mutant gene product (mRNA) and no wild type gene product (mRNA). Flow cytometric analysis of peripheral blood cells identified a subset of green fluorescent cells not observed in wild type mice. Enhanced Green Fluorescent Protein (EGFP), but not the endogenous gene, is expressed in monocytes, dendritic cells, NK cells, and brain microglia, mimicking endogenous gene expression. The same subset of peripheral blood cells isolated from heterozygote mice express detectable levels of EGFP. Immunohistochemical analysis of spleen and peripheral nerve tissue from homozygotes does not detect EGFP. These mice also express the CD45.1 (Ly5.1 or Ptprca) allele, which is atypical for the C57BL/6 congenic background, and this marker may be used to track donor cell populations in transplantation studies with C57BL/6 (CD45.2, Ly5.2 or Ptprcb) mice. These CX3CR1-GFP mice may be useful in studies of leukocyte migration and trafficking, as well as for transplantation studies.Of note, CX3CR1-GFP mice are also available with the Ptprcb allele normally found in the C57BL/6 genetic background (see Stock No. 005582).
Development
To generate the Cx3cr1 mutant allele, a targeting vector containing an Enhanced Green Fluorescent Protein (EGFP, Clontech) cDNA sequence, loxP-flanked neomycin resistance gene, herpes simplex virus thymidine kinase gene, and SV40 polyadenylation site sequence was used to disrupt the first 390 bp of exon 2. The construct was electroporated into 129P2/OlaHsd derived E14.1 embryonic stem (ES) cells which were transiently transfected with a Cre recombinase vector to remove the selection cassette. ES cells that had successfully undergone Cre-mediated recombination (removing the loxP-flanked neo cassette and leaving a single loxP site downstream of EGFP) were injected into recipient blastocysts. The resulting chimeric animals were backcrossed to C57BL/6 for ten generations before being made homozygous. During the backcross, mice were likely bred to a B6.CD45.1 congenic strain and thus also harbor the CD45.1 (Ly5.1 or Ptprca) allele rather than the CD45.2 (Ly5.2 or Ptprcb) allele normally present in C57BL/6 mice. Upon arrival at The Jackson Laboratory Repository, mice were bred with C57BL/6J inbred mice to establish the colony.A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of the 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating (one on chromosome 11 and one on chromosome 13). Breeding mutant mice together at The Jackson Laboratory Repository for several generations may have fixed these 2 markers as C57BL/6N allele-type.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (345 strains)
005582 B6.129P-Cx3cr1tm1Litt/J
007594 B6.129P2-Ptrpca Ightm1Mnz/J 006259 B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J 013198 B6.Cg-Ptprca Mir223tm1Fcam/J 002014 B6.SJL-Ptprca Pepcb/BoyJ 006584 CBy.SJL(B6)-Ptprca/J
005582 B6.129P-Cx3cr1tm1Litt/J
007172 129S6.129X1(B6)-Ptprctm1Weis/J 002725 B6.129-Ptprctm1Holm/J 007594 B6.129P2-Ptrpca Ightm1Mnz/J 007171 B6.129X1-Ptprctm1Weis/J 006259 B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J 013198 B6.Cg-Ptprca Mir223tm1Fcam/J 002014 B6.SJL-Ptprca Pepcb/BoyJ 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 007686 BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J 007173 C.129X1(B6)-Ptprctm1Weis/J 016091 C57BL/6-Ptprcltng/J 006584 CBy.SJL(B6)-Ptprca/J 014149 NOD.B6-Ptprcb/6908MrkTacJ 005616 NOD.C-(Ptprc-D1Mit262)/WehiJ
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
Cx3cr1tm1Litt/Cx3cr1+
B6.129P2-Cx3cr1tm1Litt
- nervous system phenotype
- microgliosis
- moderate following LPS exposure (MGI Ref ID J:110266)
- immune system phenotype
- increased susceptibility to experimental autoimmune encephalomyelitis
- following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit intermediate EAE severity (including transient flaccid paresis) compared with homozygous and wild-type mice (MGI Ref ID J:129712)
- mice treated with anti-NK1.1 antibodies exhibit the same severity of EAE as in homozygous mice following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- microgliosis
- moderate following LPS exposure (MGI Ref ID J:110266)
- behavior/neurological phenotype
- paresis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit transient flaccid paresis (MGI Ref ID J:129712)
- hematopoietic system phenotype
- microgliosis
- moderate following LPS exposure (MGI Ref ID J:110266)
Cx3cr1tm1Litt/Cx3cr1tm1Litt
B6.129P2-Cx3cr1tm1Litt
- mortality/aging
- increased sensitivity to induced morbidity/mortality
- following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- nervous system phenotype
- abnormal microglial cell physiology
- brain inflammation
- following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- brainstem hemorrhage
- following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- demyelination
- following induction of experimental autoimmune encephalomyelitis, mice exhibit more severe demyelination compared with similarly treated wild-type mice (MGI Ref ID J:129712)
- increased neuron apoptosis
- following LPS exposure, neuron apoptosis is increased unlike in heterozygous mice (MGI Ref ID J:110266)
- LPS-induced neurotoxicity is cell-autonomous (MGI Ref ID J:110266)
- however, mice subjected to adoptive transfer experiments and treated with an IL1 receptor antagonist exhibit reduced neuron apoptosis (MGI Ref ID J:110266)
- however, adoptive transfer into Il1r null mice abolishes neuron apoptosis (MGI Ref ID J:110266)
- increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice (MGI Ref ID J:110266)
- microgliosis
- intense and widespread following LPS exposure (MGI Ref ID J:110266)
- immune system phenotype
- *normal* immune system phenotype
- mice exhibit normal response to murine cytomegalovirus infection (MGI Ref ID J:129712)
- abnormal leukocyte physiology
- following arterial injury, monocyte recruitment is impaired compared to in similarly treated wild-type mice (MGI Ref ID J:124722)
- abnormal NK cell physiology
- following induction of experimental autoimmune encephalomyelitis, recruitment of NK cells is impaired compared to in similarly treated wild-type mice (MGI Ref ID J:129712)
- abnormal microglial cell physiology
- brain inflammation
- following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- decreased NK cell number
- in the central nervous system following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- increased susceptibility to experimental autoimmune encephalomyelitis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit earlier onset, higher mortality, and more severe EAE symptoms (nonremitting spastic paralysis, increased hemorrhagic inflammation, and extensive demyelination) compared with similarly treated wild-type mice (MGI Ref ID J:129712)
- following induction of experimental autoimmune encephalomyelitis, recruitment of NK cells is impaired compared to in similarly treated wild-type mice (MGI Ref ID J:129712)
- however, priming of encephalitogenic T cells and NKT cell numbers are normal (MGI Ref ID J:129712)
- microgliosis
- intense and widespread following LPS exposure (MGI Ref ID J:110266)
- cardiovascular system phenotype
- abnormal vascular smooth muscle physiology
- abnormal vascular wound healing
- following arterial injury, mice exhibit decreased intimal hyperplasia, impaired monocyte recruitment into the vascular wall, and decreased vascular smooth muscle cell proliferation compared to in similarly treated wild-type mice (MGI Ref ID J:124722)
- however, mice exhibit normal luminal and medial areas and platelet function (MGI Ref ID J:124722)
- brainstem hemorrhage
- following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- homeostasis/metabolism phenotype
- abnormal vascular wound healing
- following arterial injury, mice exhibit decreased intimal hyperplasia, impaired monocyte recruitment into the vascular wall, and decreased vascular smooth muscle cell proliferation compared to in similarly treated wild-type mice (MGI Ref ID J:124722)
- however, mice exhibit normal luminal and medial areas and platelet function (MGI Ref ID J:124722)
- increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice (MGI Ref ID J:110266)
- behavior/neurological phenotype
- paralysis
- following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis (MGI Ref ID J:129712)
- hematopoietic system phenotype
- decreased NK cell number
- in the central nervous system following induction of experimental autoimmune encephalomyelitis (MGI Ref ID J:129712)
- microgliosis
- intense and widespread following LPS exposure (MGI Ref ID J:110266)
- muscle phenotype
- abnormal vascular smooth muscle physiology
- cellular phenotype
- increased neuron apoptosis
- following LPS exposure, neuron apoptosis is increased unlike in heterozygous mice (MGI Ref ID J:110266)
- LPS-induced neurotoxicity is cell-autonomous (MGI Ref ID J:110266)
- however, mice subjected to adoptive transfer experiments and treated with an IL1 receptor antagonist exhibit reduced neuron apoptosis (MGI Ref ID J:110266)
- however, adoptive transfer into Il1r null mice abolishes neuron apoptosis (MGI Ref ID J:110266)
- increased susceptibility to dopaminergic neuron neurotoxicity
- mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exhibit more severe neurotoxicity than similarly treated wild-type mice (MGI Ref ID J:110266)
Cx3cr1tm1Litt/Cx3cr1tm1Litt
B6.129P-Cx3cr1tm1Litt/J
- homeostasis/metabolism phenotype
- *normal* homeostasis/metabolism phenotype
- mice exhibit normal response (dopamine nerve loss, increased body temperature, and microgliosis) to methamphetamine treatment (MGI Ref ID J:139390)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * C57BL/6
- immune system phenotype
- *normal* immune system phenotype
- abnormal leukocyte physiology
- following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice (MGI Ref ID J:162714)
- impaired macrophage chemotaxis
- following kidney ischemia and reperfusion (MGI Ref ID J:162714)
- decreased monocyte cell number
- homeostasis/metabolism phenotype
- decreased susceptibility to kidney reperfusion injury
- following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice (MGI Ref ID J:162714)
- vision/eye phenotype
- abnormal retina morphology
- choroidal neovascularization
- following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice (MGI Ref ID J:127548)
- renal/urinary system phenotype
- decreased susceptibility to kidney reperfusion injury
- following kidney ischemia and reperfusion, mice exhibit decreased kidney injury, tubular cell necrosis, and macrophage recruitment compared with similarly treated heterozygous mice (MGI Ref ID J:162714)
- nervous system phenotype
- *normal* nervous system phenotype
- normal neuronal-glial cross talk indicated by microglial response to peripheral nerve injury, 129P2/OlaHsd and C57BL/6 mixed genetic background (MGI Ref ID J:84544)
- cardiovascular system phenotype
- choroidal neovascularization
- following laser injury, more subretinal microglial cells accumulate adjacent to the choroid scar than in similarly treated wild-type mice and choroid neovascularization is twice as much as in similarly treated wild-type mice (MGI Ref ID J:127548)
- hematopoietic system phenotype
- decreased monocyte cell number
- cellular phenotype
- impaired macrophage chemotaxis
- following kidney ischemia and reperfusion (MGI Ref ID J:162714)
Cx3cr1tm1Litt/Cx3cr1tm1Litt
C.129P2-Cx3cr1tm1Litt
- immune system phenotype
- *normal* immune system phenotype
- normal monocyte extravasation and subsequent differentiation into macrophages in response to intraperitoneal injection of thioglycolate, a model of acute peritonitis (MGI Ref ID J:84544)
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd
- mortality/aging
- increased susceptibility to bacterial infection induced morbidity/mortality
- S. typhimurium-infected mice exhibit a higher organ bacterial load and die within 6 days of infection unlike similarly treated heterozygous and wild-type mice (MGI Ref ID J:95694)
- immune system phenotype
- abnormal dendritic cell physiology
- laminar propria dendritic cells exhibit impaired capacity to traverse the epithelial cell monolayer unlike in heterozygous mice (MGI Ref ID J:95694)
- laminar propria dendritic cells fail to properly sample E. coli unlike in heterozygous mice (MGI Ref ID J:95694)
- ileal villi lack intraepithelial dendritic cell extensions unlike in heterozygous mice (MGI Ref ID J:95694)
- S. typhimurium-infected mice exhibit laminar propria dendritic cells that only form globular structures that fail to cross the epithelium unlike in similarly treated heterozygous mice (MGI Ref ID J:95694)
- however, sampling of E. coli into the Peyer Patches is normal (MGI Ref ID J:95694)
- increased susceptibility to bacterial infection induced morbidity/mortality
- S. typhimurium-infected mice exhibit a higher organ bacterial load and die within 6 days of infection unlike similarly treated heterozygous and wild-type mice (MGI Ref ID J:95694)
- digestive/alimentary phenotype
- abnormal small intestinal villus morphology
- ileal villi lack intraepithelial dendritic cell extensions unlike in heterozygous mice (MGI Ref ID J:95694)
This mouse can be used to support research in many areas including:
GFP relatedCancer Research
Growth Factors/Receptors/Cytokines
Toxicology
xenograft/transplant host
Immunology and Inflammation Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
NK Cell Deficiency
Research Tools
Cancer Research
B, T, and NK cell deficiency, xenograft/transplant host
xenograft/transplant host
Cell Biology Research
Developmental Biology Research
transplantation marker for embryonic and adult tissue
Fluorescent Proteins
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: cell marker for bone marrow transplantation
Tissue/Cell Markers: glial cells
Tissue/Cell Markers: multiple
Tissue/Cell Markers: neurons
Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
Immunology and Inflammation Research
NK Cell Deficiency
Neurobiology Research
cell marker
Toxicology Research
xenograft/transplant host
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Cx3cr1tm1Litt | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Dan R Littman | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | CX3CR-GFP; CX3CR1-EGFP; CX3CR1-GFP; CX3CR1-; CX3CR1EGFP; CX3CR1GFP; | ||
| Mutation Made By | Steffen Jung, Weizmann Institute of Science | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14.1 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | EGFP expression mimics endogenous gene expression and is detected in monocytes, dendritic cells, NK cells, and brain microglia. | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Molecular Note | The endogenous locus was disrupted by the insertion of sequence encoding green fluourescent protein (GFP), replacing the first 390 bp of the coding exon (exon 2). The deleted region encoded an amino-terminal portion of the protein that is crucial for interaction with endogenous ligand, Cx3cl1. A floxed neo gene included in the targeting vector for selection was excised prior to germline transmission, leaving a single loxP site downstream of the GFP sequence. RT-PCR and flow cytometry indicated an absenceof endogenous protein and the presence GFP expression in homozygous mutant mice. [MGI Ref ID J:84544] | ||
| Gene Symbol and Name | Cx3cr1, chemokine (C-X3-C) receptor 1 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; Rbs11; V28; | ||
| Allele Symbol | Ptprca | ||
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | CD45.1; Ly5a; | ||
| Gene Symbol and Name | Ptprc, protein tyrosine phosphatase, receptor type, C | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | B220; CD45; CD45 antigen; CD45R; Cd45; GP180; L-CA; LCA; LY5; Ly-5; Lyt-4; RT7; T-lymphocyte antigen 4; T200; lymphocyte antigen 5; | ||
| Molecular Note |
Ptprca is found in strains SJL/J, STS/A, and DA. Ptprcb is found in strains C57BL/6, C3H/An, DBA/2, AKR, and many others (J:13367, J:12054, J:12077, J:8603). Twelve nucleotide differences between the a and b alleles have been identified. These base substitutions correspond to five amino-acid changes within the extracellular domain of the encoded protein. These amino-acid differences are clustered in a region that also contains the greatest divergence between mouse and rat sequences (J:22485). Note that the allele designations originally described were reversed in 1987 (J:8603); all publications prior to 1987 show SJL/J, STS/A, and DA as having the b allele and the C57BL/6J group as having the a allele (J:22341). [MGI Ref ID J:12548] [MGI Ref ID J:22485] [MGI Ref ID J:8080] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Cx3cr1tm1Litt, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106-14. [PubMed: 10805752] [MGI Ref ID J:84544]
Additional References
Cx3cr1tm1Litt relatedPtprca relatedAn G; Wang H; Tang R; Yago T; McDaniel JM; McGee S; Huo Y; Xia L. 2008. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117(25):3227-37. [PubMed: 18519846] [MGI Ref ID J:155081]
Arnold L; Henry A; Poron F; Baba-Amer Y; van Rooijen N; Plonquet A; Gherardi RK; Chazaud B. 2007. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204(5):1057-69. [PubMed: 17485518] [MGI Ref ID J:125715]
Auffray C; Fogg DK; Narni-Mancinelli E; Senechal B; Trouillet C; Saederup N; Leemput J; Bigot K; Campisi L; Abitbol M; Molina T; Charo I; Hume DA; Cumano A; Lauvau G; Geissmann F. 2009. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med 206(3):595-606. [PubMed: 19273628] [MGI Ref ID J:146747]
Bar-On L; Birnberg T; Lewis KL; Edelson BT; Bruder D; Hildner K; Buer J; Murphy KM; Reizis B; Jung S. 2010. CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 107(33):14745-50. [PubMed: 20679228] [MGI Ref ID J:163703]
Bertrand JY; Jalil A; Klaine M; Jung S; Cumano A; Godin I. 2005. Three pathways to mature macrophages in the early mouse yolk sac. Blood 106(9):3004-11. [PubMed: 16020514] [MGI Ref ID J:123941]
Bhaskar K; Konerth M; Kokiko-Cochran ON; Cardona A; Ransohoff RM; Lamb BT. 2010. Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68(1):19-31. [PubMed: 20920788] [MGI Ref ID J:167757]
Bogunovic M; Ginhoux F; Helft J; Shang L; Hashimoto D; Greter M; Liu K; Jakubzick C; Ingersoll MA; Leboeuf M; Stanley ER; Nussenzweig M; Lira SA; Randolph GJ; Merad M. 2009. Origin of the lamina propria dendritic cell network. Immunity 31(3):513-25. [PubMed: 19733489] [MGI Ref ID J:152688]
Bradfield PF; Scheiermann C; Nourshargh S; Ody C; Luscinskas FW; Rainger GE; Nash GB; Miljkovic-Licina M; Aurrand-Lions M; Imhof BA. 2007. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood 110(7):2545-55. [PubMed: 17625065] [MGI Ref ID J:147010]
Cabanski M; Wilhelm J; Zaslona Z; Steinmuller M; Fink L; Seeger W; Lohmeyer J. 2009. Genome-wide transcriptional profiling of mononuclear phagocytes recruited to mouse lungs in response to alveolar challenge with the TLR2 agonist Pam3CSK4. Am J Physiol Lung Cell Mol Physiol 297(4):L608-18. [PubMed: 19617307] [MGI Ref ID J:154138]
Cardona AE; Pioro EP; Sasse ME; Kostenko V; Cardona SM; Dijkstra IM; Huang D; Kidd G; Dombrowski S; Dutta R; Lee JC; Cook DN; Jung S; Lira SA; Littman DR; Ransohoff RM. 2006. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9(7):917-24. [PubMed: 16732273] [MGI Ref ID J:110266]
Cardona AE; Sasse ME; Liu L; Cardona SM; Mizutani M; Savarin C; Hu T; Ransohoff RM. 2008. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 112(2):256-63. [PubMed: 18347198] [MGI Ref ID J:138467]
Carreras E; Turner S; Paharkova-Vatchkova V; Mao A; Dascher C; Kovats S. 2008. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol 180(2):727-38. [PubMed: 18178810] [MGI Ref ID J:130951]
Cheret C; Gervais A; Lelli A; Colin C; Amar L; Ravassard P; Mallet J; Cumano A; Krause KH; Mallat M. 2008. Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci 28(46):12039-51. [PubMed: 19005069] [MGI Ref ID J:142401]
Chinnery HR; Humphries T; Clare A; Dixon AE; Howes K; Moran CB; Scott D; Zakrzewski M; Pearlman E; McMenamin PG. 2008. Turnover of bone marrow-derived cells in the irradiated mouse cornea. Immunology 125(4):541-8. [PubMed: 18540963] [MGI Ref ID J:144440]
Chinnery HR; Ruitenberg MJ; Plant GW; Pearlman E; Jung S; McMenamin PG. 2007. The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium. Invest Ophthalmol Vis Sci 48(4):1568-74. [PubMed: 17389486] [MGI Ref ID J:123257]
Choi JH; Cheong C; Dandamudi DB; Park CG; Rodriguez A; Mehandru S; Velinzon K; Jung IH; Yoo JY; Oh GT; Steinman RM. 2011. Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis. Immunity 35(5):819-31. [PubMed: 22078798] [MGI Ref ID J:178831]
Chorro L; Sarde A; Li M; Woollard KJ; Chambon P; Malissen B; Kissenpfennig A; Barbaroux JB; Groves R; Geissmann F. 2009. Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med 206(13):3089-100. [PubMed: 19995948] [MGI Ref ID J:155680]
Chow A; Lucas D; Hidalgo A; Mendez-Ferrer S; Hashimoto D; Scheiermann C; Battista M; Leboeuf M; Prophete C; van Rooijen N; Tanaka M; Merad M; Frenette PS. 2011. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 208(2):261-71. [PubMed: 21282381] [MGI Ref ID J:176846]
Combadiere C; Feumi C; Raoul W; Keller N; Rodero M; Pezard A; Lavalette S; Houssier M; Jonet L; Picard E; Debre P; Sirinyan M; Deterre P; Ferroukhi T; Cohen SY; Chauvaud D; Jeanny JC; Chemtob S; Behar-Cohen F; Sennlaub F. 2007. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest 117(10):2920-8. [PubMed: 17909628] [MGI Ref ID J:127548]
Corcione A; Ferretti E; Bertolotto M; Fais F; Raffaghello L; Gregorio A; Tenca C; Ottonello L; Gambini C; Furtado G; Lira S; Pistoia V. 2009. CX3CR1 is expressed by human B lymphocytes and meditates CX3CL1 driven chemotaxis of tonsil centrocytes. PLoS One 4(12):e8485. [PubMed: 20041188] [MGI Ref ID J:155943]
Dagkalis A; Wallace C; Hing B; Liversidge J; Crane IJ. 2009. CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis. Immunology 128(1):25-33. [PubMed: 19689733] [MGI Ref ID J:162296]
Davalos D; Grutzendler J; Yang G; Kim JV; Zuo Y; Jung S; Littman DR; Dustin ML; Gan WB. 2005. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8(6):752-8. [PubMed: 15895084] [MGI Ref ID J:156913]
Donnelly DJ; Longbrake EE; Shawler TM; Kigerl KA; Lai W; Tovar CA; Ransohoff RM; Popovich PG. 2011. Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages. J Neurosci 31(27):9910-22. [PubMed: 21734283] [MGI Ref ID J:174560]
Fainaru O; Woolf E; Lotem J; Yarmus M; Brenner O; Goldenberg D; Negreanu V; Bernstein Y; Levanon D; Jung S; Groner Y. 2004. Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J 23(4):969-79. [PubMed: 14765120] [MGI Ref ID J:88424]
Fuhrmann M; Bittner T; Jung CK; Burgold S; Page RM; Mitteregger G; Haass C; LaFerla FM; Kretzschmar H; Herms J. 2010. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 13(4):411-3. [PubMed: 20305648] [MGI Ref ID J:159680]
Garraud K; Cleret A; Mathieu J; Fiole D; Gauthier Y; Quesnel-Hellmann A; Tournier JN. 2012. Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax. Infect Immun 80(1):131-42. [PubMed: 22025514] [MGI Ref ID J:178960]
Geissmann F; Jung S; Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82. [PubMed: 12871640] [MGI Ref ID J:90912]
Ginhoux F; Liu K; Helft J; Bogunovic M; Greter M; Hashimoto D; Price J; Yin N; Bromberg J; Lira SA; Stanley ER; Nussenzweig M; Merad M. 2009. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 206(13):3115-30. [PubMed: 20008528] [MGI Ref ID J:155668]
Gregory AD; Capoccia BJ; Woloszynek JR; Link DC. 2010. Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. J Leukoc Biol 88(1):123-31. [PubMed: 20354107] [MGI Ref ID J:162446]
Hadis U; Wahl B; Schulz O; Hardtke-Wolenski M; Schippers A; Wagner N; Muller W; Sparwasser T; Forster R; Pabst O. 2011. Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity 34(2):237-46. [PubMed: 21333554] [MGI Ref ID J:168976]
Hapfelmeier S; Muller AJ; Stecher B; Kaiser P; Barthel M; Endt K; Eberhard M; Robbiani R; Jacobi CA; Heikenwalder M; Kirschning C; Jung S; Stallmach T; Kremer M; Hardt WD. 2008. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis. J Exp Med 205(2):437-50. [PubMed: 18268033] [MGI Ref ID J:132107]
Haynes SE; Hollopeter G; Yang G; Kurpius D; Dailey ME; Gan WB; Julius D. 2006. The P2Y(12) receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9(12):1512-9. [PubMed: 17115040] [MGI Ref ID J:116110]
Holt MP; Cheng L; Ju C. 2008. Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury. J Leukoc Biol 84(6):1410-21. [PubMed: 18713872] [MGI Ref ID J:142295]
Huang D; Shi FD; Jung S; Pien GC; Wang J; Salazar-Mather TP; He TT; Weaver JT; Ljunggren HG; Biron CA; Littman DR; Ransohoff RM. 2006. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J 20(7):896-905. [PubMed: 16675847] [MGI Ref ID J:129712]
Huang D; Wujek J; Kidd G; He TT; Cardona A; Sasse ME; Stein EJ; Kish J; Tani M; Charo IF; Proudfoot AE; Rollins BJ; Handel T; Ransohoff RM. 2005. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J 19(7):761-72. [PubMed: 15857890] [MGI Ref ID J:134548]
Ishii M; Egen JG; Klauschen F; Meier-Schellersheim M; Saeki Y; Vacher J; Proia RL; Germain RN. 2009. Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature 458(7237):524-8. [PubMed: 19204730] [MGI Ref ID J:147106]
Ishii M; Kikuta J; Shimazu Y; Meier-Schellersheim M; Germain RN. 2010. Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. J Exp Med 207(13):2793-8. [PubMed: 21135136] [MGI Ref ID J:176951]
Jaworski T; Lechat B; Demedts D; Gielis L; Devijver H; Borghgraef P; Duimel H; Verheyen F; Kugler S; Van Leuven F. 2011. Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Am J Pathol 179(4):2001-15. [PubMed: 21839061] [MGI Ref ID J:176300]
Joly S; Francke M; Ulbricht E; Beck S; Seeliger M; Hirrlinger P; Hirrlinger J; Lang KS; Zinkernagel M; Odermatt B; Samardzija M; Reichenbach A; Grimm C; Reme CE. 2009. Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol 174(6):2310-23. [PubMed: 19435787] [MGI Ref ID J:148765]
Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696] [MGI Ref ID J:142395]
Kezic J; McMenamin PG. 2008. Differential turnover rates of monocyte-derived cells in varied ocular tissue microenvironments. J Leukoc Biol 84(3):721-9. [PubMed: 18577714] [MGI Ref ID J:138301]
Kezic J; McMenamin PG. 2010. The monocyte chemokine receptor CX3CR1 does not play a significant role in the pathogenesis of experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 51(10):5121-7. [PubMed: 20463325] [MGI Ref ID J:171405]
Kezic J; Xu H; Chinnery HR; Murphy CC; McMenamin PG. 2008. Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye. Invest Ophthalmol Vis Sci 49(4):1599-608. [PubMed: 18385080] [MGI Ref ID J:136154]
Kim D; You B; Jo EK; Han SK; Simon MI; Lee SJ. 2010. NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 107(33):14851-6. [PubMed: 20679217] [MGI Ref ID J:163708]
Kim JV; Dustin ML. 2006. Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol 177(8):5269-77. [PubMed: 17015712] [MGI Ref ID J:139445]
Kim KW; Vallon-Eberhard A; Zigmond E; Farache J; Shezen E; Shakhar G; Ludwig A; Lira SA; Jung S. 2011. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood 118(22):e156-67. [PubMed: 21951685] [MGI Ref ID J:178874]
Koenigsknecht-Talboo J; Meyer-Luehmann M; Parsadanian M; Garcia-Alloza M; Finn MB; Hyman BT; Bacskai BJ; Holtzman DM. 2008. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci 28(52):14156-64. [PubMed: 19109498] [MGI Ref ID J:143879]
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M. 2011. Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol 195(4):689-701. [PubMed: 22084310] [MGI Ref ID J:178823]
Laffont S; Siddiqui KR; Powrie F. 2010. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103(+) dendritic cells. Eur J Immunol 40(7):1877-1883. [PubMed: 20432234] [MGI Ref ID J:161863]
Landsman L; Bar-On L; Zernecke A; Kim KW; Krauthgamer R; Shagdarsuren E; Lira SA; Weissman IL; Weber C; Jung S. 2009. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113(4):963-72. [PubMed: 18971423] [MGI Ref ID J:145036]
Lau-Kilby AW; Kretz CC; Pechhold S; Price JD; Dorta S; Ramos H; Trinchieri G; Tarbell KV. 2011. Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 108(6):2408-13. [PubMed: 21262836] [MGI Ref ID J:169098]
Lauro C; Di Angelantonio S; Cipriani R; Sobrero F; Antonilli L; Brusadin V; Ragozzino D; Limatola C. 2008. Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. J Immunol 180(11):7590-6. [PubMed: 18490761] [MGI Ref ID J:136344]
Lee S; Varvel NH; Konerth ME; Xu G; Cardona AE; Ransohoff RM; Lamb BT. 2010. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. Am J Pathol 177(5):2549-62. [PubMed: 20864679] [MGI Ref ID J:166257]
Lee WY; Moriarty TJ; Wong CH; Zhou H; Strieter RM; van Rooijen N; Chaconas G; Kubes P. 2010. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nat Immunol 11(4):295-302. [PubMed: 20228796] [MGI Ref ID J:158972]
Leuschner F; Panizzi P; Chico-Calero I; Lee WW; Ueno T; Cortez-Retamozo V; Waterman P; Gorbatov R; Marinelli B; Iwamoto Y; Chudnovskiy A; Figueiredo JL; Sosnovik DE; Pittet MJ; Swirski FK; Weissleder R; Nahrendorf M. 2010. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 107(11):1364-73. [PubMed: 20930148] [MGI Ref ID J:178180]
Lewis CA; Solomon JN; Rossi FM; Krieger C. 2009. Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1. Glia 57(13):1410-9. [PubMed: 19243075] [MGI Ref ID J:156201]
Li L; Huang L; Sung SS; Vergis AL; Rosin DL; Rose CE Jr; Lobo PI; Okusa MD. 2008. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int 74(12):1526-37. [PubMed: 18843253] [MGI Ref ID J:162714]
Liang KJ; Lee JE; Wang YD; Ma W; Fontainhas AM; Fariss RN; Wong WT. 2009. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Invest Ophthalmol Vis Sci 50(9):4444-51. [PubMed: 19443728] [MGI Ref ID J:154542]
Lin KL; Suzuki Y; Nakano H; Ramsburg E; Gunn MD. 2008. CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J Immunol 180(4):2562-72. [PubMed: 18250467] [MGI Ref ID J:131979]
Liu K; Victora GD; Schwickert TA; Guermonprez P; Meredith MM; Yao K; Chu FF; Randolph GJ; Rudensky AY; Nussenzweig M. 2009. In Vivo Analysis of Dendritic Cell Development and Homeostasis. Science :. [PubMed: 19286519] [MGI Ref ID J:147362]
Liu P; Patil S; Rojas M; Fong AM; Smyth SS; Patel DD. 2006. CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol 26(9):2056-62. [PubMed: 16809547] [MGI Ref ID J:124722]
Liu Z; Condello C; Schain A; Harb R; Grutzendler J. 2010. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis. J Neurosci 30(50):17091-101. [PubMed: 21159979] [MGI Ref ID J:167723]
London A; Itskovich E; Benhar I; Kalchenko V; Mack M; Jung S; Schwartz M. 2011. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med 208(1):23-39. [PubMed: 21220455] [MGI Ref ID J:176855]
Luche H; Ardouin L; Teo P; See P; Henri S; Merad M; Ginhoux F; Malissen B. 2011. The earliest intrathymic precursors of CD8alpha(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. Eur J Immunol 41(8):2165-75. [PubMed: 21630253] [MGI Ref ID J:176820]
Lyszkiewicz M; Witzlau K; Pommerencke J; Krueger A. 2011. Chemokine receptor CX3CR1 promotes dendritic cell development under steady-state conditions. Eur J Immunol 41(5):1256-65. [PubMed: 21425158] [MGI Ref ID J:175414]
Masse GX; Corcuff E; Strick-Marchand H; Guy-Grand D; Tafuri-Bladt A; Albert ML; Lantz O; Di Santo JP. 2007. Gamma c cytokines condition the progressive differentiation of CD4+ T cells. Proc Natl Acad Sci U S A 104(39):15442-7. [PubMed: 17855567] [MGI Ref ID J:125207]
Massena S; Christoffersson G; Hjertstrom E; Zcharia E; Vlodavsky I; Ausmees N; Rolny C; Li JP; Phillipson M. 2010. A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood 116(11):1924-31. [PubMed: 20530797] [MGI Ref ID J:164516]
McAvoy EF; McDonald B; Parsons SA; Wong CH; Landmann R; Kubes P. 2011. The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia. J Immunol 186(4):2592-601. [PubMed: 21217012] [MGI Ref ID J:169174]
McComb JG; Ranganathan M; Liu XH; Pilewski JM; Ray P; Watkins SC; Choi AM; Lee JS. 2008. CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol 173(4):949-61. [PubMed: 18772344] [MGI Ref ID J:139658]
Meyer-Luehmann M; Spires-Jones TL; Prada C; Garcia-Alloza M; de Calignon A; Rozkalne A; Koenigsknecht-Talboo J; Holtzman DM; Bacskai BJ; Hyman BT. 2008. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451(7179):720-4. [PubMed: 18256671] [MGI Ref ID J:132628]
Mionnet C; Buatois V; Kanda A; Milcent V; Fleury S; Lair D; Langelot M; Lacoeuille Y; Hessel E; Coffman R; Magnan A; Dombrowicz D; Glaichenhaus N; Julia V. 2010. CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med 16(11):1305-12. [PubMed: 21037587] [MGI Ref ID J:166138]
Mueller-Steiner S; Zhou Y; Arai H; Roberson ED; Sun B; Chen J; Wang X; Yu G; Esposito L; Mucke L; Gan L. 2006. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 51(6):703-14. [PubMed: 16982417] [MGI Ref ID J:113649]
Nahrendorf M; Swirski FK; Aikawa E; Stangenberg L; Wurdinger T; Figueiredo JL; Libby P; Weissleder R; Pittet MJ. 2007. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204(12):3037-47. [PubMed: 18025128] [MGI Ref ID J:128499]
Niess JH; Adler G. 2010. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol 184(4):2026-37. [PubMed: 20089703] [MGI Ref ID J:159471]
Niess JH; Brand S; Gu X; Landsman L; Jung S; McCormick BA; Vyas JM; Boes M; Ploegh HL; Fox JG; Littman DR; Reinecker HC. 2005. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307(5707):254-8. [PubMed: 15653504] [MGI Ref ID J:95694]
Orr AG; Orr AL; Li XJ; Gross RE; Traynelis SF. 2009. Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci 12(7):872-8. [PubMed: 19525944] [MGI Ref ID J:163956]
Paolicelli RC; Bolasco G; Pagani F; Maggi L; Scianni M; Panzanelli P; Giustetto M; Ferreira TA; Guiducci E; Dumas L; Ragozzino D; Gross CT. 2011. Synaptic pruning by microglia is necessary for normal brain development. Science 333(6048):1456-8. [PubMed: 21778362] [MGI Ref ID J:175794]
Platt AM; Bain CC; Bordon Y; Sester DP; Mowat AM. 2010. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J Immunol 184(12):6843-54. [PubMed: 20483766] [MGI Ref ID J:161138]
Qu C; Edwards EW; Tacke F; Angeli V; Llodra J; Sanchez-Schmitz G; Garin A; Haque NS; Peters W; van Rooijen N; Sanchez-Torres C; Bromberg J; Charo IF; Jung S; Lira SA; Randolph GJ. 2004. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med 200(10):1231-41. [PubMed: 15534368] [MGI Ref ID J:94536]
Rogers JT; Morganti JM; Bachstetter AD; Hudson CE; Peters MM; Grimmig BA; Weeber EJ; Bickford PC; Gemma C. 2011. CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity. J Neurosci 31(45):16241-50. [PubMed: 22072675] [MGI Ref ID J:177835]
Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng CN; Bjorkstrom NK; Malmberg KJ; Lindbom L; Eriksson EE. 2010. Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice. Am J Pathol 177(1):493-500. [PubMed: 20472897] [MGI Ref ID J:162128]
Saederup N; Cardona AE; Croft K; Mizutani M; Cotleur AC; Tsou CL; Ransohoff RM; Charo IF. 2010. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5(10):e13693. [PubMed: 21060874] [MGI Ref ID J:166664]
Salazar-Gonzalez RM; Niess JH; Zammit DJ; Ravindran R; Srinivasan A; Maxwell JR; Stoklasek T; Yadav R; Williams IR; Gu X; McCormick BA; Pazos MA; Vella AT; Lefrancois L; Reinecker HC; McSorley SJ. 2006. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 24(5):623-32. [PubMed: 16713979] [MGI Ref ID J:113363]
Sapoznikov A; Pewzner-Jung Y; Kalchenko V; Krauthgamer R; Shachar I; Jung S. 2008. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nat Immunol 9(4):388-95. [PubMed: 18311142] [MGI Ref ID J:133263]
Sathaliyawala T; O'Gorman WE; Greter M; Bogunovic M; Konjufca V; Hou ZE; Nolan GP; Miller MJ; Merad M; Reizis B. 2010. Mammalian target of rapamycin controls dendritic cell development downstream of flt3 ligand signaling. Immunity 33(4):597-606. [PubMed: 20933441] [MGI Ref ID J:165522]
Sawanobori Y; Ueha S; Kurachi M; Shimaoka T; Talmadge JE; Abe J; Shono Y; Kitabatake M; Kakimi K; Mukaida N; Matsushima K. 2008. Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111(12):5457-66. [PubMed: 18375791] [MGI Ref ID J:136844]
Schulz O; Jaensson E; Persson EK; Liu X; Worbs T; Agace WW; Pabst O. 2009. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med 206(13):3101-14. [PubMed: 20008524] [MGI Ref ID J:155671]
Sciume G; De Angelis G; Benigni G; Ponzetta A; Morrone S; Santoni A; Bernardini G. 2011. CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow. Blood 117(17):4467-75. [PubMed: 21364193] [MGI Ref ID J:177799]
Soehnlein O; Zernecke A; Eriksson EE; Rothfuchs AG; Pham CT; Herwald H; Bidzhekov K; Rottenberg ME; Weber C; Lindbom L. 2008. Neutrophil secretion products pave the way for inflammatory monocytes. Blood 112(4):1461-71. [PubMed: 18490516] [MGI Ref ID J:138439]
Song JW; Misgeld T; Kang H; Knecht S; Lu J; Cao Y; Cotman SL; Bishop DL; Lichtman JW. 2008. Lysosomal activity associated with developmental axon pruning. J Neurosci 28(36):8993-9001. [PubMed: 18768693] [MGI Ref ID J:141170]
Synowitz M; Glass R; Farber K; Markovic D; Kronenberg G; Herrmann K; Schnermann J; Nolte C; van Rooijen N; Kiwit J; Kettenmann H. 2006. A1 adenosine receptors in microglia control glioblastoma-host interaction. Cancer Res 66(17):8550-7. [PubMed: 16951167] [MGI Ref ID J:112410]
Tacke F; Alvarez D; Kaplan TJ; Jakubzick C; Spanbroek R; Llodra J; Garin A; Liu J; Mack M; van Rooijen N; Lira SA; Habenicht AJ; Randolph GJ. 2007. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 117(1):185-94. [PubMed: 17200718] [MGI Ref ID J:117437]
Tagliani E; Shi C; Nancy P; Tay CS; Pamer EG; Erlebacher A. 2011. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med 208(9):1901-16. [PubMed: 21825019] [MGI Ref ID J:177594]
Thomas DM; Francescutti-Verbeem DM; Kuhn DM. 2008. Methamphetamine-induced neurotoxicity and microglial activation are not mediated by fractalkine receptor signaling. J Neurochem 106(2):696-705. [PubMed: 18410508] [MGI Ref ID J:139390]
Tighe RM; Li Z; Potts EN; Frush S; Liu N; Gunn MD; Foster WM; Noble PW; Hollingsworth JW. 2011. Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. J Immunol 187(9):4800-8. [PubMed: 21930959] [MGI Ref ID J:179462]
Ulmann L; Hirbec H; Rassendren F. 2010. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J 29(14):2290-300. [PubMed: 20562826] [MGI Ref ID J:162082]
Vallon-Eberhard A; Landsman L; Yogev N; Verrier B; Jung S. 2006. Transepithelial pathogen uptake into the small intestinal lamina propria. J Immunol 176(4):2465-9. [PubMed: 16456006] [MGI Ref ID J:106225]
Varol C; Landsman L; Fogg DK; Greenshtein L; Gildor B; Margalit R; Kalchenko V; Geissmann F; Jung S. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204(1):171-80. [PubMed: 17190836] [MGI Ref ID J:125312]
Varol C; Vallon-Eberhard A; Elinav E; Aychek T; Shapira Y; Luche H; Fehling HJ; Hardt WD; Shakhar G; Jung S. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31(3):502-12. [PubMed: 19733097] [MGI Ref ID J:152689]
Varvel NH; Bhaskar K; Kounnas MZ; Wagner SL; Yang Y; Lamb BT; Herrup K. 2009. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest 119(12):3692-702. [PubMed: 19907078] [MGI Ref ID J:155100]
Vukovic J; Blomster LV; Chinnery HR; Weninger W; Jung S; McMenamin PG; Ruitenberg MJ. 2010. Bone marrow chimeric mice reveal a role for CXCR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium. J Leukoc Biol 88(4):645-54. [PubMed: 20610801] [MGI Ref ID J:165615]
Waddell A; Ahrens R; Steinbrecher K; Donovan B; Rothenberg ME; Munitz A; Hogan SP. 2011. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol 186(10):5993-6003. [PubMed: 21498668] [MGI Ref ID J:173219]
Weber B; Saurer L; Schenk M; Dickgreber N; Mueller C. 2011. CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. Eur J Immunol 41(3):773-9. [PubMed: 21341263] [MGI Ref ID J:175420]
Willart MA; Jan de Heer H; Hammad H; Soullie T; Deswarte K; Clausen BE; Boon L; Hoogsteden HC; Lambrecht BN. 2009. The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen. J Exp Med 206(12):2823-35. [PubMed: 19858325] [MGI Ref ID J:154860]
Wojcik AJ; Skaflen MD; Srinivasan S; Hedrick CC. 2008. A Critical Role for ABCG1 in Macrophage Inflammation and Lung Homeostasis. J Immunol 180(6):4273-82. [PubMed: 18322240] [MGI Ref ID J:132952]
Woodfin A; Voisin MB; Beyrau M; Colom B; Caille D; Diapouli FM; Nash GB; Chavakis T; Albelda SM; Rainger GE; Meda P; Imhof BA; Nourshargh S. 2011. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol 12(8):761-9. [PubMed: 21706006] [MGI Ref ID J:174437]
Wu LJ; Vadakkan KI; Zhuo M. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55(8):810-21. [PubMed: 17357150] [MGI Ref ID J:156095]
Xi H; Katschke KJ Jr; Helmy KY; Wark PA; Kljavin N; Clark H; Eastham-Anderson J; Shek T; Roose-Girma M; Ghilardi N; van Lookeren Campagne M. 2010. Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1. J Exp Med 207(1):7-16, S1-5. [PubMed: 20038601] [MGI Ref ID J:156819]
Xiong Z; Leme AS; Ray P; Shapiro SD; Lee JS. 2011. CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-{alpha} and IL-6 and Promote Cigarette Smoke-Induced Emphysema. J Immunol 186(5):3206-14. [PubMed: 21278339] [MGI Ref ID J:169385]
Zhang N; Schroppel B; Lal G; Jakubzick C; Mao X; Chen D; Yin N; Jessberger R; Ochando JC; Ding Y; Bromberg JS. 2009. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity 30(3):458-69. [PubMed: 19303390] [MGI Ref ID J:147032]
Zhao L; Ma W; Fariss RN; Wong WT. 2009. Retinal vascular repair and neovascularization are not dependent on CX3CR1 signaling in a model of ischemic retinopathy. Exp Eye Res 88(6):1004-13. [PubMed: 19176215] [MGI Ref ID J:151032]
Basu S; Ray A; Dittel BN. 2011. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187(11):5720-32. [PubMed: 22048769] [MGI Ref ID J:179699]
Cho RH; Sieburg HB; Muller-Sieburg CE. 2008. A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. Blood 111(12):5553-61. [PubMed: 18413859] [MGI Ref ID J:162992]
De Santo C; Arscott R; Booth S; Karydis I; Jones M; Asher R; Salio M; Middleton M; Cerundolo V. 2010. Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. Nat Immunol 11(11):1039-46. [PubMed: 20890286] [MGI Ref ID J:166540]
Ewald SJ; McKenzie IFC. 1979. Immunochemical characterization of the Ly-5 alloantigens on thymocytes. Immunogenetics 8:583-587. [MGI Ref ID J:13367]
Gardam S; Turner VM; Anderton H; Limaye S; Basten A; Koentgen F; Vaux DL; Silke J; Brink R. 2011. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood 117(15):4041-51. [PubMed: 21300983] [MGI Ref ID J:172843]
Harp JA; Davis BS; Ewald SJ. 1984. Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J Immunol 133(1):10-5. [PubMed: 6233370] [MGI Ref ID J:7453]
Held W; Clevers H; Grosschedl R. 2003. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. Eur J Immunol 33(5):1393-8. [PubMed: 12731066] [MGI Ref ID J:85394]
Huber S; Hoffmann R; Muskens F; Voehringer D. 2010. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116(17):3311-20. [PubMed: 20625006] [MGI Ref ID J:165869]
Iijima N; Mattei LM; Iwasaki A. 2011. Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A 108(1):284-9. [PubMed: 21173243] [MGI Ref ID J:169008]
Janowska-Wieczorek A; Majka M; Kijowski J; Baj-Krzyworzeka M; Reca R; Turner AR; Ratajczak J; Emerson SG; Kowalska MA; Ratajczak MZ. 2001. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood 98(10):3143-9. [PubMed: 11698303] [MGI Ref ID J:109863]
Jiang S; Alberich-Jorda M; Zagozdzon R; Parmar K; Fu Y; Mauch P; Banu N; Makriyannis A; Tenen DG; Avraham S; Groopman JE; Avraham HK. 2011. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 117(3):827-38. [PubMed: 21063029] [MGI Ref ID J:168507]
Kasai M; Leclerc JC; Shen FW; Cantor H. 1979. Identification of Ly 5 on the surface of `natural killer' cells in normal and athymic inbred mouse strains. Immunogenetics 8:153-159. [MGI Ref ID J:12054]
Kitano M; Moriyama S; Ando Y; Hikida M; Mori Y; Kurosaki T; Okada T. 2011. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34(6):961-72. [PubMed: 21636294] [MGI Ref ID J:174014]
Komuro K ; Itakura K ; Boyse EA ; John M. 1975. Ly-5: a new lymphocyte antigen system. Immunogenetics 1:452-456. [MGI Ref ID J:12077]
Leskov IL; Whitsett J; Vasquez-Vivar J; Stokes KY. 2011. NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction. Free Radic Biol Med 51(12):2300-8. [PubMed: 22033010] [MGI Ref ID J:179407]
McAleer JP; Liu B; Li Z; Ngoi SM; Dai J; Oft M; Vella AT. 2010. Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization. J Leukoc Biol 88(1):21-31. [PubMed: 20130220] [MGI Ref ID J:162449]
McNally A; Hill GR; Sparwasser T; Thomas R; Steptoe RJ. 2011. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108(18):7529-34. [PubMed: 21502514] [MGI Ref ID J:172217]
Mobraaten LE. 1994. Ly5 gene nomenclature, C57BL/6J and SJL/J - A history of change JAX Notes Summer(458):2. [MGI Ref ID J:22341]
Moebius J; van den Broek M; Groettrup M; Basler M. 2010. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. Eur J Immunol 40(12):3439-49. [PubMed: 21108466] [MGI Ref ID J:174578]
Morse HC 3rd; Shen FW; Hammerling U. 1987. Genetic nomenclature for loci controlling mouse lymphocyte antigens. Immunogenetics 25(2):71-8. [PubMed: 3817907] [MGI Ref ID J:8603]
Pepper M; Pagan AJ; Igyarto BZ; Taylor JJ; Jenkins MK. 2011. Opposing signals from the bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35(4):583-95. [PubMed: 22018468] [MGI Ref ID J:177635]
Pulliam-Leath AC; Ciccone SL; Nalepa G; Li X; Si Y; Miravalle L; Smith D; Yuan J; Li J; Anur P; Orazi A; Vance GH; Yang FC; Hanenberg H; Bagby GC; Clapp DW. 2010. Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia. Blood 116(16):2915-20. [PubMed: 20606166] [MGI Ref ID J:165874]
Raschke WC; Hendricks M; Chen CM. 1995. Genetic basis of antigenic differences between three alleles of Ly5 (CD45) in mice. Immunogenetics 41(2-3):144-7. [PubMed: 7806287] [MGI Ref ID J:22485]
Roman E; Shino H; Qin FX; Liu YJ. 2010. Cutting edge: Hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol 185(7):3819-23. [PubMed: 20802149] [MGI Ref ID J:164214]
Schluns KS; Williams K; Ma A; Zheng XX; Lefrancois L. 2002. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168(10):4827-31. [PubMed: 11994430] [MGI Ref ID J:109854]
Seldin MF; D'Hoostelaere LA; Steinberg AD; Saga Y; Morse HC 3rd. 1987. Allelic variants of Ly-5 in inbred and natural populations of mice. Immunogenetics 26(1-2):74-8. [PubMed: 2886425] [MGI Ref ID J:8805]
Shang X; Cancelas JA; Li L; Guo F; Liu W; Johnson JF; Ficker A; Daria D; Geiger H; Ratner N; Zheng Y. 2011. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. J Biol Chem 286(27):24068-78. [PubMed: 21572048] [MGI Ref ID J:175297]
Shen FW; Saga Y; Litman G; Freeman G; Tung JS; Cantor H; Boyse EA. 1985. Cloning of Ly-5 cDNA. Proc Natl Acad Sci U S A 82(21):7360-3. [PubMed: 3864163] [MGI Ref ID J:8080]
Shen FW; Tung JS; Boyse EA. 1986. Further definition of the Ly-5 system. Immunogenetics 24(3):146-9. [PubMed: 3489673] [MGI Ref ID J:8430]
Shulzhenko N; Morgun A; Matzinger P. 2009. Spontaneous mutation in the Cd79b gene leads to a block in B-lymphocyte development at the C' (early pre-B) stage. Genes Immun 10(8):722-6. [PubMed: 19727123] [MGI Ref ID J:157450]
Siggs OM; Arnold CN; Huber C; Pirie E; Xia Y; Lin P; Nemazee D; Beutler B. 2011. The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow. Nat Immunol 12(5):434-40. [PubMed: 21423172] [MGI Ref ID J:171925]
So T; Soroosh P; Eun SY; Altman A; Croft M. 2011. Antigen-independent signalosome of CARMA1, PKC{theta}, and TNF receptor-associated factor 2 (TRAF2) determines NF-{kappa}B signaling in T cells. Proc Natl Acad Sci U S A 108(7):2903-8. [PubMed: 21282629] [MGI Ref ID J:169068]
Teng EC; Racioppi L; Means AR. 2011. A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. J Leukoc Biol 90(5):897-909. [PubMed: 21816924] [MGI Ref ID J:178260]
Waterstrat A; Liang Y; Swiderski CF; Shelton BJ; Van Zant G. 2010. Congenic interval of CD45/Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment. Blood 115(2):408-17. [PubMed: 19901263] [MGI Ref ID J:155980]
Westmuckett AD; Thacker KM; Moore KL. 2011. Tyrosine sulfation of native mouse psgl-1 is required for optimal leukocyte rolling on p-selectin in vivo. PLoS One 6(5):e20406. [PubMed: 21633705] [MGI Ref ID J:172569]
Yang G; Hisha H; Cui Y; Fan T; Jin T; Li Q; Lian Z; Hosaka N; Li Y; Ikehara S. 2002. A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells. Stem Cells 20(3):241-8. [PubMed: 12004082] [MGI Ref ID J:109853]
Yeager AM; Shinn C; Shinohara M; Pardoll DM. 1993. Hematopoietic cell transplantation in the twitcher mouse. The effects of pretransplant conditioning with graded doses of busulfan. Transplantation 56(1):185-90. [PubMed: 8101401] [MGI Ref ID J:14381]
Zebedee SL; Barritt DS; Raschke WC. 1991. Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles. Dev Immunol 1(4):243-54. [PubMed: 1822988] [MGI Ref ID J:12548]
de Andres-Aguayo L; Varas F; Kallin EM; Infante JF; Wurst W; Floss T; Graf T. 2011. Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice. Blood 118(3):554-64. [PubMed: 21613258] [MGI Ref ID J:174870]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygous for the Cx3cr1 mutant allele and homozygous for the Ptprca allele. Mating System Homozygote x Homozygote (Female x Male) 18-JUL-08 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $172.00 Female or Male Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt
Pairs /Price (US dollars $) Pair Genotype $344.00 Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt x Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $223.60 Female or Male Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt
Pairs /Price (US dollars $) Pair Genotype $447.20 Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt x Homozygous for Ptprca, Homozygous for Cx3cr1tm1Litt Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.