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| These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. This strain represents an effective tool for generating epiblast-derived specific targeted mutants that would be useful to study genes critical to embryogenesis. | |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 28-FEB-09 Species laboratory mouse Generation N11+F4 (18-NOV-09) Donating Investigator Valeri Zimmerman, University of Cincinnati Description
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. When crossed to a reporter line, Beta-galactosidase activity is detected in the epiblast cells at embryonic day 6.5, with little or no activity in other cells at gastrulation. Some activity is also detected in extra embryonic derivatives of the epiblast, the yolk sac mesoderm and amnion. No activity is detected in primitive endoderm derived tissues, visceral endoderm. The Donating Investigator has not attempted to make the strain homozygous. This strain represents an effective tool for generating epiblast-derived specific targeted mutants.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing sequence encoding cre recombinase, 12.5Kb of upstream regulatory sequence of the mouse Sox2, SRY-box containing gene 2, and a rabbit Beta-globin poly-adenylation sequence, was introduced into B6CBAF1 donor eggs. The resulting founder animals were initially crossed to C57BL/6 mice, and then crossed to outbred Swiss Webster mice. The mice were then backcrossed to C57BL/6 for 11 generations. The Donating Investigator has not attempted to make the strain homozygous.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Sox2-cre)1Amc allele
004783 STOCK Tg(Sox2-cre)1Amc/J View Strains carrying Tg(Sox2-cre)1Amc (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Sox2-cre)1Amc | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Andrew P McMahon | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Sox2-cre; Sox2Cre; | ||
| Mutation Made By | Shigemi Hayashi, Columbia University | ||
| Strain of Origin | (C57BL/6 x CBA)F1 | ||
| Site of Expression | epiblast cells at embryonic day 6.5, with little or no activity in other cells at gastrulation; some activity is also detected in extra embryonic derivatives of the epi-blast, the yolk sac mesoderm and amnion; no activity is detected in primitive endoderm derived tissues, visceral endoderm | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Sox2, SRY-box containing gene 2, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Sox2-cre)1Amc, transgene insertion 1, Andrew P McMahon | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Sox2-cre; Sox2Cre; | ||
| Driver Note | Sox2 | ||
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse Sox2 promoter. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline,cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos irregardless of whether or not they inherit the transgene. [MGI Ref ID J:124941] [MGI Ref ID J:134483] [MGI Ref ID J:83040] [MGI Ref ID J:86588] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. [PubMed: 14516668] [MGI Ref ID J:83040]
Additional References
Tg(Sox2-cre)1Amc relatedArnold SJ; Hofmann UK; Bikoff EK; Robertson EJ. 2008. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135(3):501-11. [PubMed: 18171685] [MGI Ref ID J:131055]
Artner I; Blanchi B; Raum JC; Guo M; Kaneko T; Cordes S; Sieweke M; Stein R. 2007. MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A 104(10):3853-8. [PubMed: 17360442] [MGI Ref ID J:120055]
Barrow JR; Howell WD; Rule M; Hayashi S; Thomas KR; Capecchi MR; McMahon AP. 2007. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312(1):312-20. [PubMed: 18028899] [MGI Ref ID J:130205]
Biondi CA; Das D; Howell M; Islam A; Bikoff EK; Hill CS; Robertson EJ. 2007. Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J 404(2):235-45. [PubMed: 17300215] [MGI Ref ID J:141589]
Bissonauth V; Roy S; Gravel M; Guillemette S; Charron J. 2006. Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis. Development 133(17):3429-40. [PubMed: 16887817] [MGI Ref ID J:112223]
Carroll TJ; Park JS; Hayashi S; Majumdar A; McMahon AP. 2005. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9(2):283-92. [PubMed: 16054034] [MGI Ref ID J:100575]
Chen J; Nathans J. 2007. Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell 13(3):325-37. [PubMed: 17765677] [MGI Ref ID J:124941]
Chu GC; Dunn NR; Anderson DC; Oxburgh L; Robertson EJ. 2004. Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development 131(15):3501-12. [PubMed: 15215210] [MGI Ref ID J:92066]
Di-Gregorio A; Sancho M; Stuckey DW; Crompton LA; Godwin J; Mishina Y; Rodriguez TA. 2007. BMP signalling inhibits premature neural differentiation in the mouse embryo. Development 134(18):3359-69. [PubMed: 17699604] [MGI Ref ID J:124681]
Dubois NC; Adolphe C; Ehninger A; Wang RA; Robertson EJ; Trumpp A. 2008. Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function. Development 135(14):2455-65. [PubMed: 18550708] [MGI Ref ID J:137630]
Elling U; Klasen C; Eisenberger T; Anlag K; Treier M. 2006. Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A 103(44):16319-24. [PubMed: 17060609] [MGI Ref ID J:115635]
Feng JQ; Scott G; Guo D; Jiang B; Harris M; Ward T; Ray M; Bonewald LF; Harris SE; Mishina Y. 2008. Generation of a conditional null allele for Dmp1 in mouse. Genesis 46(2):87-91. [PubMed: 18257058] [MGI Ref ID J:135314]
French CA; Groszer M; Preece C; Coupe AM; Rajewsky K; Fisher SE. 2007. Generation of mice with a conditional Foxp2 null allele. Genesis 45(7):440-6. [PubMed: 17619227] [MGI Ref ID J:125023]
Garci-Higuera I; Manchado E; Dubus P; Canamero M; Mendez J; Moreno S; Malumbres M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10(7):802-11. [PubMed: 18552834] [MGI Ref ID J:137456]
Guttormsen J; Koster MI; Stevens JR; Roop DR; Williams T; Winger QA. 2008. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol 317(1):187-95. [PubMed: 18353300] [MGI Ref ID J:136080]
Hayashi S; Tenzen T; McMahon AP. 2003. Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis 37(2):51-3. [PubMed: 14595839] [MGI Ref ID J:86588]
He C; Hu H; Braren R; Fong SY; Trumpp A; Carlson TR; Wang RA. 2008. c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo. Development 135(14):2467-77. [PubMed: 18550710] [MGI Ref ID J:137645]
Hou Y; Li F; Karin M; Ostrowski MC. 2008. Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn 237(10):2926-2935. [PubMed: 18816823] [MGI Ref ID J:139642]
Huang X; Litingtung Y; Chiang C. 2007. Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum Mol Genet 16(12):1454-68. [PubMed: 17468181] [MGI Ref ID J:125109]
Huang X; Litingtung Y; Chiang C. 2007. Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord. Development 134(11):2095-105. [PubMed: 17507410] [MGI Ref ID J:122547]
Inagaki M; Komatsu Y; Scott G; Yamada G; Ray M; Ninomiya-Tsuji J; Mishina Y. 2008. Generation of a conditional mutant allele for Tab1 in mouse. Genesis 46(8):431-9. [PubMed: 18693278] [MGI Ref ID J:140317]
Jin J; Desai BN; Navarro B; Donovan A; Andrews NC; Clapham DE. 2008. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322(5902):756-60. [PubMed: 18974357] [MGI Ref ID J:140630]
Katsanou V; Milatos S; Yiakouvaki A; Sgantzis N; Kotsoni A; Alexiou M; Harokopos V; Aidinis V; Hemberger M; Kontoyiannis DL. 2009. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol 29(10):2762-76. [PubMed: 19307312] [MGI Ref ID J:149149]
Kwon GS; Viotti M; Hadjantonakis AK. 2008. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev Cell 15(4):509-20. [PubMed: 18854136] [MGI Ref ID J:143286]
Lee D; Yu M; Lee E; Kim H; Yang Y; Kim K; Pannicia C; Kurie JM; Threadgill DW. 2009. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J Clin Invest 119(9):2702-13. [PubMed: 19690388] [MGI Ref ID J:152703]
Li Y; Zhang H; Litingtung Y; Chiang C. 2006. Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A 103(17):6548-53. [PubMed: 16611729] [MGI Ref ID J:109101]
Liu C; Nathans J. 2008. An essential role for frizzled 5 in mammalian ocular development. Development 135(21):3567-76. [PubMed: 18832390] [MGI Ref ID J:143446]
Liu C; Wang Y; Smallwood PM; Nathans J. 2008. An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci 28(22):5641-53. [PubMed: 18509025] [MGI Ref ID J:136390]
Lobov IB; Rao S; Carroll TJ; Vallance JE; Ito M; Ondr JK; Kurup S; Glass DA; Patel MS; Shu W; Morrisey EE; McMahon AP; Karsenty G; Lang RA. 2005. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437(7057):417-21. [PubMed: 16163358] [MGI Ref ID J:101493]
Lu CC; Robertson EJ. 2004. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273(1):149-59. [PubMed: 15302604] [MGI Ref ID J:93140]
MacDonald ST; Bamforth SD; Chen CM; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; Lewandoski M; Bhattacharya S. 2008. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3):448-57. [PubMed: 18440989] [MGI Ref ID J:137951]
Mugford JW; Yu J; Kobayashi A; McMahon AP. 2009. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol 333(2):312-23. [PubMed: 19591821] [MGI Ref ID J:152419]
Nadeau V; Guillemette S; Belanger LF; Jacob O; Roy S; Charron J. 2009. Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development 136(8):1363-74. [PubMed: 19304888] [MGI Ref ID J:147279]
Oda H; Okamoto I; Murphy N; Chu J; Price SM; Shen MM; Torres-Padilla ME; Heard E; Reinberg D. 2009. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol 29(8):2278-95. [PubMed: 19223465] [MGI Ref ID J:147765]
Panic L; Tamarut S; Sticker-Jantscheff M; Barkic M; Solter D; Uzelac M; Grabusic K; Volarevic S. 2006. Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26(23):8880-91. [PubMed: 17000767] [MGI Ref ID J:117590]
Pondarre C; Antiochos BB; Campagna DR; Clarke SL; Greer EL; Deck KM; McDonald A; Han AP; Medlock A; Kutok JL; Anderson SA; Eisenstein RS; Fleming MD. 2006. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet 15(6):953-64. [PubMed: 16467350] [MGI Ref ID J:106838]
Raffel GD; Chu GC; Jesneck JL; Cullen DE; Bronson RT; Bernard OA; Gilliland DG. 2009. Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen. Mol Cell Biol 29(2):333-41. [PubMed: 18981216] [MGI Ref ID J:145030]
Rajagopal J; Carroll TJ; Guseh JS; Bores SA; Blank LJ; Anderson WJ; Yu J; Zhou Q; McMahon AP; Melton DA. 2008. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development 135(9):1625-34. [PubMed: 18367557] [MGI Ref ID J:134483]
Robertson EJ; Charatsi I; Joyner CJ; Koonce CH; Morgan M; Islam A; Paterson C; Lejsek E; Arnold SJ; Kallies A; Nutt SL; Bikoff EK. 2007. Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development 134(24):4335-45. [PubMed: 18039967] [MGI Ref ID J:129204]
Rodda SJ; McMahon AP. 2006. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133(16):3231-44. [PubMed: 16854976] [MGI Ref ID J:114494]
Screen M; Dean W; Cross JC; Hemberger M. 2008. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development 135(19):3311-20. [PubMed: 18776147] [MGI Ref ID J:138768]
Stenman JM; Rajagopal J; Carroll TJ; Ishibashi M; McMahon J; McMahon AP. 2008. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322(5905):1247-50. [PubMed: 19023080] [MGI Ref ID J:142352]
Tabaries S; Lemieux M; Aubin J; Jeannotte L. 2007. Comparative analysis of Hoxa5 allelic series. Genesis 45(4):218-28. [PubMed: 17417799] [MGI Ref ID J:125040]
Tian H; Jeong J; Harfe BD; Tabin CJ; McMahon AP. 2005. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132(1):133-42. [PubMed: 15576405] [MGI Ref ID J:94270]
Tian Y; Lei L; Cammarano M; Nekrasova T; Minden A. 2009. Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation. Mech Dev 126(8-9):710-20. [PubMed: 19464366] [MGI Ref ID J:152821]
Tsiairis CD; McMahon AP. 2008. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol 317(2):480-5. [PubMed: 18395198] [MGI Ref ID J:136115]
Vincent SD; Dunn NR; Hayashi S; Norris DP; Robertson EJ. 2003. Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev 17(13):1646-62. [PubMed: 12842913] [MGI Ref ID J:84300]
Vincent SD; Dunn NR; Sciammas R; Shapiro-Shalef M; Davis MM; Calame K; Bikoff EK; Robertson EJ. 2005. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development 132(6):1315-25. [PubMed: 15750184] [MGI Ref ID J:101718]
Vincent SD; Robertson EJ. 2003. Highly efficient transgene-independent recombination directed by a maternally derived SOX2CRE transgene. Genesis 37(2):54-6. [PubMed: 14595840] [MGI Ref ID J:86587]
Wang S; Zhang J; Zhao A; Hipkens S; Magnuson MA; Gu G. 2007. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev 124(11-12):898-910. [PubMed: 17928203] [MGI Ref ID J:127471]
Xie J; Wu T; Xu K; Huang IK; Cleaver O; Huang CL. 2009. Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol 175(3):1315-27. [PubMed: 19644017] [MGI Ref ID J:152906]
Yu J; Carroll TJ; Rajagopal J; Kobayashi A; Ren Q; McMahon AP. 2009. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136(1):161-71. [PubMed: 19060336] [MGI Ref ID J:142685]
Zong Y; Panikkar A; Xu J; Antoniou A; Raynaud P; Lemaigre F; Stanger BZ. 2009. Notch signaling controls liver development by regulating biliary differentiation. Development 136(10):1727-39. [PubMed: 19369401] [MGI Ref ID J:148015]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice can be bred as hemizygotes. The Donating Investigator has not attempted to make the strain homozygous. Mating System Noncarrier x Hemizygote (Female x Male) 28-FEB-09 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Hemizygous for Tg(Sox2-cre)1Amc
Pairs /Price (US dollars $) Pair Genotype $297.85 Hemizygous for Tg(Sox2-cre)1Amc x Noncarrier $297.85 Noncarrier x Hemizygous for Tg(Sox2-cre)1Amc
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Hemizygous for Tg(Sox2-cre)1Amc
Pairs /Price (US dollars $) Pair Genotype $387.30 Hemizygous for Tg(Sox2-cre)1Amc x Noncarrier $387.30 Noncarrier x Hemizygous for Tg(Sox2-cre)1Amc
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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