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This strain enables temporal control of floxed gene expression by tamoxifen induction in vivo.


Strain Information

Former Names B6.129-Gt(ROSA)26Sortm1(cre/ESR1)Tyj/J    (Changed: 17-MAR-10 )
B6;129-Gt(ROSA)26Sortm1(cre/ESR1)Tyj/J    (Changed: 12-JUN-08 )
Type Congenic; Targeted Mutation;
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Mating SystemHomozygote x Homozygote         (Female x Male)   16-DEC-09
Specieslaboratory mouse
GenerationN9+N1F3 (06-MAY-15)
Generation Definitions
Donating InvestigatorDr. Tyler Jacks,   Massachusetts Institute of Technology

A conditional Cre-ERT2 (Cre recombinase - estrogen receptor T2) cassette was introduced to the gene. The ERT2 moiety retains the Cre recombinase in the cytoplasm until tamoxifen administration releases this inhibition, thus permitting the recombination of genomic loxP sites. Efficient tamoxifen-induced Cre-mediated recombination throughout the body has been demonstrated through crosses with a Cre-responsive beta galactosidase reporter strain. This strain enables temporal control of floxed gene expression in vivo and is reportedly more sensitive to tamoxifen than Stock No. 004847. Homozygotes are viable and fertile.

A conditional Cre-ERT2 (estrogen receptor T2) cassette was inserted to intron 1 of the gene. The mutation was created in 129S4/SvJae-derived J1 embryonic stem (ES) cells and backcrossed 8 times to C57BL/6 by the donating laboratory.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Gt(ROSA)26Sor
002292   129-Gt(ROSA)26Sor/J
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
013205   129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
003310   129S-Gt(ROSA)26Sortm1Sor/J
013207   129S-Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Mmjax
009043   129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007844   129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
017626   B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
026283   B6(Cg)-Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
024540   B6(Cg)-Gt(ROSA)26Sortm1(Sstr3/GFP)Bky/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
024512   B6.129-Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
017492   B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
009669   B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J
008513   B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
013587   B6.129P2-Gt(ROSA)26Sortm3Nik/J
022367   B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J
009086   B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
012930   B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J
009044   B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007743   B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
009673   B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J
022626   B6.129S6(SJL)-Gt(ROSA)26Sortm2.1(mix1b-mCherry)Mgn/Mmjax
002192   B6.129S7-Gt(ROSA)26Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
026294   B6.Cg(129S)-Gt(ROSA)26Sortm2.2Ksvo/J
021071   B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
017983   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm9(tetO-Dnmt3b_i1)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
026930   B6.Cg-Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen/J
026931   B6.Cg-Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen/J
026932   B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen/J
007914   B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
012567   B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
024109   B6.Cg-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
021188   B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
025106   B6.Cg-Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/J
025109   B6.Cg-Gt(ROSA)26Sortm80.1(CAG-COP4*L132C/EYFP)Hze/J
007909   B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
017455   B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J
024857   B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
010527   B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J
016262   B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
017962   B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
021847   B6;129-Gt(ROSA)26Sortm1Ytchn/J
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
009253   B6;129-Gt(ROSA)26Sortm2Nat/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
021429   B6;129-Gt(ROSA)26Sortm4(CAG-GFP*)Nat/J
021039   B6;129-Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/J
023843   B6;129-Gt(ROSA)26Sortm6(Fzd6)Nat/J
010523   B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
024708   B6;129P2-Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/J
002073   B6;129S-Gt(ROSA)26Sor/J
018385   B6;129S-Gt(ROSA)26Sortm1(CAG-COX8A/Dendra2)Dcc/J
022516   B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J
013206   B6;129S-Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat/Mmjax
018397   B6;129S-Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/J
023139   B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J
024846   B6;129S-Gt(ROSA)26Sortm2.1Ksvo/J
012569   B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
012570   B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
014538   B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
021875   B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J
021876   B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J
024105   B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
024750   B6;129S4-Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/J
023035   B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
016999   B6;129S6-Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/J
007908   B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007905   B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
024106   B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J
026175   B6J.129(B6N)-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
026179   B6J.129(Cg)-Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
026219   B6N.129-Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
016226   B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
019016   B6N.129S6(Cg)-Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
023537   B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
026220   B6N;129-Gt(ROSA)26Sortm2(CAG-CHRM3*,-mCitrine)Ute/J
026261   B6N;129-Gt(ROSA)26Sortm3(CAG-Chrm3*,-mCitrine)Ute/J
025701   B6N;129S1-Gt(ROSA)26Sortm1(Grem1)Svok/J
019120   BALB/c-Gt(ROSA)26Sortm10(Lmp1)Rsky/J
009670   C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
002955   C.129S7-Gt(ROSA)26Sor/J
025322   C57BL/6-Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008517   C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J
012637   C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J
012638   C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
020458   C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
008040   CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
026862   D2.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/SjJ
026863   D2.129S4(B6)-Gt(ROSA)26Sortm1Sor/SjJ
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
016977   FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
010920   FVB;129P2-Gt(ROSA)26Sortm1.1(birA)Mejr/J
016603   NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
010675   STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
022793   STOCK Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/J
023451   STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5,-CD4)19Mnz/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
018121   STOCK Gt(ROSA)26Sortm1(birA)Mejr Gata4tm3.1Wtp/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
010701   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax
022386   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/J
024858   STOCK Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
025983   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Mef2ctm1.1Wtp/Mmjax
025977   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Zfpm2tm1.1Wtp /Mmjax
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
025671   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(tetO-Fgf10)1Jaw/SpdlJ
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
010812   STOCK Gt(ROSA)26Sortm1.2(CAG-EGFP)Fsh/Mmjax
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
023898   STOCK Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Mmjax
026570   STOCK Gt(ROSA)26Sortm1Embph/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018906   STOCK Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
009674   STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
012266   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
025982   STOCK Rbpjtm1.1Wtp Gt(ROSA)26Sortm1.1birA)Mejr/Mmjax
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (186 strains)

Strains carrying other alleles of cre/ERT2
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
026512   B6(Cg)-Tg(TPO-cre/ERT2)1139Tyj/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
020940   B6.129P2(C)-Cx3cr1tm2.1(cre/ERT2)Jung/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
027116   B6.129P2-Cd19tm1(cre/ERT2)Rsky/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
023676   B6.Cg-Hprttm331(Ple275-icre/ERT2)Ems/Mmjax
023677   B6.Cg-Hprttm332(Ple272-icre/ERT2)Ems/Mmjax
023678   B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems/Mmjax
023679   B6.Cg-Hprttm334(Ple279-icre/ERT2)Ems/Mmjax
023680   B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems/Mmjax
023681   B6.Cg-Hprttm336(Ple134-icre/ERT2)Ems/Mmjax
023682   B6.Cg-Hprttm337(Ple285-icre/ERT2)Ems/Mmjax
023683   B6.Cg-Hprttm338(Ple284-icre/ERT2)Ems/Mmjax
023684   B6.Cg-Hprttm339(Ple280-icre/ERT2)Ems/Mmjax
023685   B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems/Mmjax
023686   B6.Cg-Hprttm341(Ple273-icre/ERT2)Ems/Mmjax
023687   B6.Cg-Hprttm342(Ple282-icre/ERT2)Ems/Mmjax
023688   B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems/Mmjax
023689   B6.Cg-Hprttm344(Ple5-icre/ERT2)Ems/Mmjax
023690   B6.Cg-Hprttm345(icre/ERT2)Ems/Mmjax
023691   B6.Cg-Hprttm346(Ple264-icre/ERT2)Ems/Mmjax
023692   B6.Cg-Hprttm347(Ple155-icre/ERT2)Ems/Mmjax
023693   B6.Cg-Hprttm348(Ple265-icre/ERT2)Ems/Mmjax
023694   B6.Cg-Hprttm349(Ple293-icre/ERT2)Ems/Mmjax
023695   B6.Cg-Hprttm350(Ple232-icre/ERT2)Ems/Mmjax
023696   B6.Cg-Hprttm351(Ple198-icre/ERT2)Ems/Mmjax
023697   B6.Cg-Hprttm352(Ple291-icre/ERT2)Ems/Mmjax
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
021189   B6.Cg-Pvalbtm1.1(cre/ERT2)Hze/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022357   B6.Cg-Tg(Arc-cre/ERT2)MRhn/CdnyJ
026516   B6.Cg-Tg(Avil-cre/ERT2)AJwo/J
022390   B6.Cg-Tg(CDX2-Cre/ERT2)752Erf/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
024709   B6.Cg-Tg(Ins1-cre/ERT)1Lphi/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
019079   B6.FVB-Tg(Myh11-cre/ERT2)1Soff/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
018937   B6;C-Tg(Erv4-cre/ERT2*)657Slp/J
025809   B6;CBA-Tg(Fgfr3-icre/ERT2)4-2Wdr/J
025808   B6;CBA-Tg(Nkx2-1-cre/ERT2)1Kess/J
024768   B6;CBA-Tg(Upk2-icre/ERT2)1Ccc/J
017496   B6;D-Tg(Lfng-TagRFP/cre/ERT2)8Amc/J
018682   B6;D-Tg(Meox1-TagRFP/cre/ERT2)30Amc/J
018683   B6;D-Tg(Wnt11-TagRFP/cre/ERT2)28Amc/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
025124   C57BL/6-Tg(Adipoq-cre/ERT2)1Soff/J
025867   C57BL/6J-Tg(Neurod1-cre/ERT2)M1Fcal/J
024760   FVB/N-Tg(Ddx4-cre/ERT2)1Dcas/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
008861   STOCK Tg(Ela1-Cre/ERT2)1Stof/J
022763   STOCK Tg(Eno2-cre/ERT2)1Pohlk/J
027681   STOCK Tg(Hnf1b-cre/ERT2)1Jfer/J
019380   STOCK Tg(IVL-cre/ERT2)1Blpn/J
017948   STOCK Tg(KRT18-cre/ERT2)23Blpn/J
017947   STOCK Tg(Krt8-cre/ERT2)17Blpn/J
018829   STOCK Tg(Sox9-cre/ERT2)1Msan/J
025520   STOCK Tg(T-cre/ERT2)1Lwd/J
View Strains carrying other alleles of cre/ERT2     (138 strains)

Additional Web Information

Information about the Rosa26 locus on the Soriano lab web page

Introduction to Cre-lox technology


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Inducible

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Allele Name targeted mutation 1, Tyler Jacks
Allele Type Targeted (Inducible, cre- or Flp-expressing)
Common Name(s) Cre-ERT2; Gt(ROSA)26Sortm1(cre/ESR1)Tyj; R26-Cre-ERT2; Rosa26CreER;
Mutation Made ByDr. Tyler Jacks,   Massachusetts Institute of Technology
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Site of ExpressionEfficient tamoxifen-induced Cre-mediated recombination throughout the body has been demonstrated through crosses with a Cre-responsive beta galactosidase reporter strain.
Expressed Gene cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene,
Gene Symbol and Name Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Chromosome 6
Gene Common Name(s) AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; SETD5-AS1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26;
Driver Note Gt(ROSA)26Sor
Inducible Note induced by tamoxifen
Molecular Note A cassette containing Cre-ERT2 was inserted into the locus. [MGI Ref ID J:118233]


Genotyping Information

Genotyping Protocols

Gt(ROSA)26Sortm1(cre/ERT2)Tyj, High Resolution Melting
Gt(ROSA)26Sortm1(cre/ERT2)Tyj, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Ventura A; Kirsch DG; McLaughlin ME; Tuveson DA; Grimm J; Lintault L; Newman J; Reczek EE; Weissleder R; Jacks T. 2007. Restoration of p53 function leads to tumour regression in vivo. Nature 445(7128):661-5. [PubMed: 17251932]  [MGI Ref ID J:118233]

Additional References

Gt(ROSA)26Sortm1(cre/ERT2)Tyj related

Bekes M; Okamoto K; Crist SB; Jones MJ; Chapman JR; Brasher BB; Melandri FD; Ueberheide BM; Denchi EL; Huang TT. 2013. DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells. Cell Rep 5(3):826-38. [PubMed: 24210823]  [MGI Ref ID J:205527]

Bjerknes M; Khandanpour C; Moroy T; Fujiyama T; Hoshino M; Klisch TJ; Ding Q; Gan L; Wang J; Martin MG; Cheng H. 2012. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol 362(2):194-218. [PubMed: 22185794]  [MGI Ref ID J:180770]

Bourgo RJ; Ehmer U; Sage J; Knudsen ES. 2011. RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo. Mol Biol Cell 22(7):931-9. [PubMed: 21289097]  [MGI Ref ID J:183003]

Brady CA; Jiang D; Mello SS; Johnson TM; Jarvis LA; Kozak MM; Kenzelmann Broz D; Basak S; Park EJ; McLaughlin ME; Karnezis AN; Attardi LD. 2011. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145(4):571-83. [PubMed: 21565614]  [MGI Ref ID J:173395]

Chen H; Gu X; Liu Y; Wang J; Wirt SE; Bottino R; Schorle H; Sage J; Kim SK. 2011. PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature 478(7369):349-55. [PubMed: 21993628]  [MGI Ref ID J:177411]

Clarke SE; Kang JX; Ma DW. 2014. The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo. Transgenic Res 23(3):489-501. [PubMed: 24622775]  [MGI Ref ID J:213660]

Davis RJ; Hsu CW; Tsai YT; Wert KJ; Sancho-Pelluz J; Lin CS; Tsang SH. 2013. Therapeutic Margins in a Novel Preclinical Model of Retinitis Pigmentosa. J Neurosci 33(33):13475-13483. [PubMed: 23946405]  [MGI Ref ID J:200898]

Desai TJ; Brownfield DG; Krasnow MA. 2014. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507(7491):190-4. [PubMed: 24499815]  [MGI Ref ID J:207468]

Dimitrova N; Zamudio JR; Jong RM; Soukup D; Resnick R; Sarma K; Ward AJ; Raj A; Lee JT; Sharp PA; Jacks T. 2014. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Mol Cell 54(5):777-90. [PubMed: 24857549]  [MGI Ref ID J:215235]

Du W; Amarachintha S; Sipple J; Schick J; Steinbrecher K; Pang Q. 2013. Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation. J Immunol 191(5):2806-17. [PubMed: 23926327]  [MGI Ref ID J:205786]

Du W; Erden O; Wilson A; Sipple JM; Schick J; Mehta P; Myers KC; Steinbrecher KA; Davies SM; Pang Q. 2014. Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood 123(12):1938-47. [PubMed: 24501220]  [MGI Ref ID J:210175]

Fragoso R; Mao T; Wang S; Schaffert S; Gong X; Yue S; Luong R; Min H; Yashiro-Ohtani Y; Davis M; Pear W; Chen CZ. 2012. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 8(8):e1002855. [PubMed: 22916024]  [MGI Ref ID J:188125]

Greter M; Helft J; Chow A; Hashimoto D; Mortha A; Agudo-Cantero J; Bogunovic M; Gautier EL; Miller J; Leboeuf M; Lu G; Aloman C; Brown BD; Pollard JW; Xiong H; Randolph GJ; Chipuk JE; Frenette PS; Merad M. 2012. GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity 36(6):1031-46. [PubMed: 22749353]  [MGI Ref ID J:187407]

Greter M; Lelios I; Pelczar P; Hoeffel G; Price J; Leboeuf M; Kundig TM; Frei K; Ginhoux F; Merad M; Becher B. 2012. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity 37(6):1050-60. [PubMed: 23177320]  [MGI Ref ID J:191069]

Gupta A; Wodziak D; Tun M; Bouley DM; Lowe AW. 2013. Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem 288(6):4321-33. [PubMed: 23209296]  [MGI Ref ID J:195573]

Guzman-Ayala M; Sachs M; Koh FM; Onodera C; Bulut-Karslioglu A; Lin CJ; Wong P; Nitta R; Song JS; Ramalho-Santos M. 2015. Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development 142(1):118-27. [PubMed: 25480920]  [MGI Ref ID J:217689]

Haigis KM; Kendall KR; Wang Y; Cheung A; Haigis MC; Glickman JN; Niwa-Kawakita M; Sweet-Cordero A; Sebolt-Leopold J; Shannon KM; Settleman J; Giovannini M; Jacks T. 2008. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet 40(5):600-8. [PubMed: 18372904]  [MGI Ref ID J:132357]

Hoshii T; Tadokoro Y; Naka K; Ooshio T; Muraguchi T; Sugiyama N; Soga T; Araki K; Yamamura K; Hirao A. 2012. mTORC1 is essential for leukemia propagation but not stem cell self-renewal. J Clin Invest 122(6):2114-29. [PubMed: 22622041]  [MGI Ref ID J:190434]

Jiang D; Brady CA; Johnson TM; Lee EY; Park EJ; Scott MP; Attardi LD. 2011. Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A 108(41):17123-8. [PubMed: 21969549]  [MGI Ref ID J:177455]

Kaiser WJ; Sridharan H; Huang C; Mandal P; Upton JW; Gough PJ; Sehon CA; Marquis RW; Bertin J; Mocarski ES. 2013. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem 288(43):31268-79. [PubMed: 24019532]  [MGI Ref ID J:204906]

Kaiser WJ; Upton JW; Long AB; Livingston-Rosanoff D; Daley-Bauer LP; Hakem R; Caspary T; Mocarski ES. 2011. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471(7338):368-72. [PubMed: 21368762]  [MGI Ref ID J:170815]

Kataoka H; Hayashi M; Kobayashi K; Ding G; Tanaka Y; Nishikawa S. 2013. Region-specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6-positive caudal-lateral primitive mesoderm. Exp Hematol 41(6):567-581.e9. [PubMed: 23438573]  [MGI Ref ID J:214903]

Lang M; Wither RG; Colic S; Wu C; Monnier PP; Bardakjian BL; Zhang L; Eubanks JH. 2014. Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation. Hum Mol Genet 23(2):303-18. [PubMed: 24009314]  [MGI Ref ID J:204519]

Lee J; Kim KE; Choi DK; Jang JY; Jung JJ; Kiyonari H; Shioi G; Chang W; Suda T; Mochizuki N; Nakaoka Y; Komuro I; Yoo OJ; Koh GY. 2013. Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling for recovery of ischemic retinopathy. Sci Transl Med 5(203):203ra127. [PubMed: 24048525]  [MGI Ref ID J:213456]

Leite de Oliveira R; Deschoemaeker S; Henze AT; Debackere K; Finisguerra V; Takeda Y; Roncal C; Dettori D; Tack E; Jonsson Y; Veschini L; Peeters A; Anisimov A; Hofmann M; Alitalo K; Baes M; D'hooge J; Carmeliet P; Mazzone M. 2012. Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell 22(2):263-77. [PubMed: 22897855]  [MGI Ref ID J:191820]

Li Z; Yu J; Hosohama L; Nee K; Gkountela S; Chaudhari S; Cass AA; Xiao X; Clark AT. 2015. The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice. EMBO J 34(6):748-58. [PubMed: 25519955]  [MGI Ref ID J:220035]

Meylan E; Dooley AL; Feldser DM; Shen L; Turk E; Ouyang C; Jacks T. 2009. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462(7269):104-7. [PubMed: 19847165]  [MGI Ref ID J:154041]

Mounce BC; Mboko WP; Bigley TM; Terhune SS; Tarakanova VL. 2013. A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. J Virol 87(13):7314-25. [PubMed: 23616648]  [MGI Ref ID J:198443]

Mu P; Han YC; Betel D; Yao E; Squatrito M; Ogrodowski P; de Stanchina E; D'Andrea A; Sander C; Ventura A. 2009. Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev 23(24):2806-11. [PubMed: 20008931]  [MGI Ref ID J:155803]

Nguyen AT; Taranova O; He J; Zhang Y. 2011. DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis. Blood 117(25):6912-22. [PubMed: 21521783]  [MGI Ref ID J:174817]

Norrie JL; Lewandowski JP; Bouldin CM; Amarnath S; Li Q; Vokes MS; Ehrlich LI; Harfe BD; Vokes SA. 2014. Dynamics of BMP signaling in limb bud mesenchyme and polydactyly. Dev Biol 393(2):270-81. [PubMed: 25034710]  [MGI Ref ID J:214075]

Ohlsson E; Hasemann MS; Willer A; Lauridsen FK; Rapin N; Jendholm J; Porse BT. 2014. Initiation of MLL-rearranged AML is dependent on C/EBPalpha. J Exp Med 211(1):5-13. [PubMed: 24367003]  [MGI Ref ID J:208356]

Pajcini KV; Corbel SY; Sage J; Pomerantz JH; Blau HM. 2010. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell 7(2):198-213. [PubMed: 20682446]  [MGI Ref ID J:163316]

Parra S; Huang X; Charbeneau RA; Wade SM; Kaur K; Rorabaugh BR; Neubig RR. 2014. Conditional disruption of interactions between Galphai2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury. BMC Pharmacol Toxicol 15:29. [PubMed: 24899231]  [MGI Ref ID J:217517]

Pierini R; Juruj C; Perret M; Jones CL; Mangeot P; Weiss DS; Henry T. 2012. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ 19(10):1709-21. [PubMed: 22555457]  [MGI Ref ID J:204790]

Pitzonka L; Ullas S; Chinnam M; Povinelli BJ; Fisher DT; Golding M; Appenheimer MM; Nemeth MJ; Evans S; Goodrich DW. 2014. The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse. PLoS One 9(5):e97628. [PubMed: 24830368]  [MGI Ref ID J:216341]

Pitzonka L; Wang X; Ullas S; Wolff DW; Wang Y; Goodrich DW. 2013. The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine. Mol Cell Biol 33(17):3505-14. [PubMed: 23816884]  [MGI Ref ID J:204752]

Piunti A; Rossi A; Cerutti A; Albert M; Jammula S; Scelfo A; Cedrone L; Fragola G; Olsson L; Koseki H; Testa G; Casola S; Helin K; d'Adda di Fagagna F; Pasini D. 2014. Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. Nat Commun 5:3649. [PubMed: 24728135]  [MGI Ref ID J:213248]

Ranghini EJ; Dressler GR. 2015. Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol 399(2):296-305. [PubMed: 25617721]  [MGI Ref ID J:219797]

Riordan JD; Drury LJ; Smith RP; Brett BT; Rogers LM; Scheetz TE; Dupuy AJ. 2014. Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens. BMC Genomics 15:1150. [PubMed: 25526783]  [MGI Ref ID J:221375]

Ripoche D; Gout J; Pommier RM; Jaafar R; Zhang CX; Bartholin L; Bertolino P. 2012. Generation of a conditional mouse model to target Acvr1b disruption in adult tissues. Genesis :. [PubMed: 23109354]  [MGI Ref ID J:188629]

Roderick JE; Hermance N; Zelic M; Simmons MJ; Polykratis A; Pasparakis M; Kelliher MA. 2014. Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A 111(40):14436-41. [PubMed: 25246544]  [MGI Ref ID J:216468]

Roset R; Inagaki A; Hohl M; Brenet F; Lafrance-Vanasse J; Lange J; Scandura JM; Tainer JA; Keeney S; Petrini JH. 2014. The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev 28(5):451-62. [PubMed: 24532689]  [MGI Ref ID J:209141]

Sabour D; Xu X; Chung AC; Le Menuet D; Ko K; Tapia N; Arauzo-Bravo MJ; Gentile L; Greber B; Hubner K; Sebastiano V; Wu G; Scholer HR; Cooney AJ. 2014. Germ cell nuclear factor regulates gametogenesis in developing gonads. PLoS One 9(8):e103985. [PubMed: 25140725]  [MGI Ref ID J:221000]

Schwab KR; Smith GD; Dressler GR. 2013. Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol 373(1):64-71. [PubMed: 23063797]  [MGI Ref ID J:190993]

Sfeir A; de Lange T. 2012. Removal of shelterin reveals the telomere end-protection problem. Science 336(6081):593-7. [PubMed: 22556254]  [MGI Ref ID J:184522]

Sin YY; Ballantyne LL; Mukherjee K; St Amand T; Kyriakopoulou L; Schulze A; Funk CD. 2013. Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism. PLoS One 8(11):e80001. [PubMed: 24224027]  [MGI Ref ID J:209211]

Smeets MF; DeLuca E; Wall M; Quach JM; Chalk AM; Deans AJ; Heierhorst J; Purton LE; Izon DJ; Walkley CR. 2014. The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. J Clin Invest 124(8):3551-65. [PubMed: 24960165]  [MGI Ref ID J:213779]

Snyder EL; Watanabe H; Magendantz M; Hoersch S; Chen TA; Wang DG; Crowley D; Whittaker CA; Meyerson M; Kimura S; Jacks T. 2013. Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma. Mol Cell 50(2):185-99. [PubMed: 23523371]  [MGI Ref ID J:198227]

Thapa P; Das J; McWilliams D; Shapiro M; Sundsbak R; Nelson-Holte M; Tangen S; Anderson J; Desiderio S; Hiebert S; Sant'angelo DB; Shapiro VS. 2013. The transcriptional repressor NKAP is required for the development of iNKT cells. Nat Commun 4:1582. [PubMed: 23481390]  [MGI Ref ID J:205750]

Unnisa Z; Clark JP; Roychoudhury J; Thomas E; Tessarollo L; Copeland NG; Jenkins NA; Grimes HL; Kumar AR. 2012. Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress. Blood 120(25):4973-81. [PubMed: 23091297]  [MGI Ref ID J:192624]

Viatour P; Somervaille TC; Venkatasubrahmanyam S; Kogan S; McLaughlin ME; Weissman IL; Butte AJ; Passegue E; Sage J. 2008. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3(4):416-28. [PubMed: 18940733]  [MGI Ref ID J:149791]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintained as a live colony, homozygotes or heterozygotes may be bred.
Mating SystemHomozygote x Homozygote         (Female x Male)   16-DEC-09
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj x Homozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj x Homozygous for Gt(ROSA)26Sortm1(cre/ERT2)Tyj  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Mice are subject to US Patent 6040430.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.