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| These transgenic mice express a codon-improved Cre recombinase (iCre) under the control of the mouse Pf4 (platelet factor 4), or Cxcl4, promoter. Cre recombinase expression is detected in the majority of megakaryocytes. This strain represents an effective tool for generating megakaryocyte lineage-restricted specific-targeted mutants. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names C57BL/6-Tg(Cxcl4-cre)Q3Rsko/J (Changed: 05-MAR-09 ) Type Coisogenic; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Noncarrier x Hemizygote (Female x Male) 15-JAN-09 Species laboratory mouse Generation F?+F6 (06-JAN-11)
Generation DefinitionsDonating Investigator Radek Skoda, University Hospital Basel Description
These transgenic mice express a codon-improved Cre recombinase (iCre) under the control of the mouse Pf4 (platelet factor 4), or Cxcl4, promoter. Cre recombinase expression is detected in the majority of megakaryocytes. Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The BAC clone used to generate this strain also contains 4 other genes: Cxcl5, Cxcl7, Cxcl15 and Cxcl3. The additional copy of these chemokine genes in the BAC has no effect on blood count of the mutant mice. This strain represents an effective tool for generating megakaryocyte lineage-restricted specific-targeted mutants.Development
A 100kb BAC containing the mouse Pf4 (platelet factor 4), or Cxcl4, gene with exon 1 replaced by a construct containing the mouse Pf4 (platelet factor 4), or Cxcl4, promoter, a codon-improved Cre recombinase (iCre) sequence, bovine growth hormone polyadenylation signal, nuclear localization signal and a myc tag was injected into fertilized C57BL/6 fertilized oocytes. Founder line Q3 was established, carrying 1 copy of the transgene. Founder animals were maintained as hemizygotes on the C57BL/6 background.A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Pf4
007243 B6;SJL-Tg(Cxcl4-F5)1Dgi/J View Strains carrying other alleles of Pf4 (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cardiovascular Research
Cre-lox System
Cre-lox System
Cre Recombinase Expression
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Pf4-cre)Q3Rsko | ||
|---|---|---|---|
| Allele Name | transgene insertion Q3, Radek C Skoda | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Pf4-Cre; Tg(Cxcl4-cre)Q3Rsko; | ||
| Mutation Made By | Radek Skoda, University Hospital Basel | ||
| Strain of Origin | C57BL/6 | ||
| Site of Expression | Cre is detected in the majority of megakaryocytes. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Pf4, platelet factor 4, mouse, laboratory | ||
| Driver Note | Pf4 | ||
| Molecular Note | A transgene was created from a BAC where cre-recombinase is driven by the Cxcl4 (Platelet factor 4) promoter. This transgene also contains the Cxcl3, Cxcl5, Ppbp, and Cxcl15 genes. This line has one copy of the transgene inserted with expression restricted to megakaryocytes and platelets, as demonstrated by RT-PCR and Western blotting. [MGI Ref ID J:127229] | ||
| Gene Symbol and Name | Tg(Pf4-cre)Q3Rsko, transgene insertion Q3, Radek C Skoda | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Pf4-Cre; Tg(Cxcl4-cre)Q3Rsko; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Cxc14-cre),Separated MCA
Tg(Cxc14-cre), Separated PCR
Tg(Cxc14-cre), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Tiedt R; Schomber T; Hao-Shen H; Skoda RC. 2007. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood 109(4):1503-6. [PubMed: 17032923] [MGI Ref ID J:127229]
Additional References
Tg(Pf4-cre)Q3Rsko relatedBarata L; Miwa T; Sato S; Kim D; Mohammed I; Song WC. 2013. Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack. J Immunol 190(6):2886-95. [PubMed: 23390291] [MGI Ref ID J:193605]
Bender M; Eckly A; Hartwig JH; Elvers M; Pleines I; Gupta S; Krohne G; Jeanclos E; Gohla A; Gurniak C; Gachet C; Witke W; Nieswandt B. 2010. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood 116(10):1767-75. [PubMed: 20530287] [MGI Ref ID J:164521]
Bender M; Hofmann S; Stegner D; Chalaris A; Bosl M; Braun A; Scheller J; Rose-John S; Nieswandt B. 2010. Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood 116(17):3347-55. [PubMed: 20644114] [MGI Ref ID J:165863]
Bertozzi CC; Schmaier AA; Mericko P; Hess PR; Zou Z; Chen M; Chen CY; Xu B; Lu MM; Zhou D; Sebzda E; Santore MT; Merianos DJ; Stadtfeld M; Flake AW; Graf T; Skoda R; Maltzman JS; Koretzky GA; Kahn ML. 2010. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood 116(4):661-70. [PubMed: 20363774] [MGI Ref ID J:162815]
Bhavaraju K; Lakhani PR; Dorsam RT; Jin J; Hitchcock IS; Sanjay A; Kunapuli SP. 2011. G(12/13) signaling pathways substitute for integrin alphaIIbbeta3-signaling for thromboxane generation in platelets. PLoS One 6(2):e16586. [PubMed: 21347357] [MGI Ref ID J:171092]
Calaminus SD; Guitart A; Sinclair A; Schachtner H; Watson SP; Holyoake TL; Kranc KR; Machesky LM. 2012. Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLoS One 7(12):e51361. [PubMed: 23300543] [MGI Ref ID J:195733]
Carramolino L; Fuentes J; Garcia-Andres C; Azcoitia V; Riethmacher D; Torres M. 2010. Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis. Circ Res 106(7):1197-201. [PubMed: 20203303] [MGI Ref ID J:171033]
Debrincat MA; Josefsson EC; James C; Henley KJ; Ellis S; Lebois M; Betterman KL; Lane RM; Rogers KL; White MJ; Roberts AW; Harvey NL; Metcalf D; Kile BT. 2012. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood 119(24):5850-8. [PubMed: 22374700] [MGI Ref ID J:186573]
Eckly A; Strassel C; Freund M; Cazenave JP; Lanza F; Gachet C; Leon C. 2009. Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation. Blood 113(14):3182-9. [PubMed: 18984861] [MGI Ref ID J:148137]
Finney BA; Schweighoffer E; Navarro-Nunez L; Benezech C; Barone F; Hughes CE; Langan SA; Lowe KL; Pollitt AY; Mourao-Sa D; Sheardown S; Nash GB; Smithers N; Reis e Sousa C; Tybulewicz VL; Watson SP. 2012. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood 119(7):1747-56. [PubMed: 22186994] [MGI Ref ID J:181715]
Gambaryan S; Friebe A; Walter U. 2012. Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets? Blood 119(22):5335-6. [PubMed: 22653960] [MGI Ref ID J:185197]
Halene S; Gao Y; Hahn K; Massaro S; Italiano JE Jr; Schulz V; Lin S; Kupfer GM; Krause DS. 2010. Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood 116(11):1942-50. [PubMed: 20525922] [MGI Ref ID J:164524]
Haling JR; Monkley SJ; Critchley DR; Petrich BG. 2011. Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood 117(5):1719-22. [PubMed: 20971947] [MGI Ref ID J:177971]
Hitchcock IS; Fox NE; Prevost N; Sear K; Shattil SJ; Kaushansky K. 2008. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood 111(2):596-604. [PubMed: 17925492] [MGI Ref ID J:130102]
Huang H; Woo AJ; Waldon Z; Schindler Y; Moran TB; Zhu HH; Feng GS; Steen H; Cantor AB. 2012. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev 26(14):1587-601. [PubMed: 22759635] [MGI Ref ID J:185343]
Josefsson EC; James C; Henley KJ; Debrincat MA; Rogers KL; Dowling MR; White MJ; Kruse EA; Lane RM; Ellis S; Nurden P; Mason KD; O'Reilly LA; Roberts AW; Metcalf D; Huang DC; Kile BT. 2011. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 208(10):2017-31. [PubMed: 21911424] [MGI Ref ID J:177288]
Jurak Begonja A; Hoffmeister KM; Hartwig JH; Falet H. 2011. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood 118(8):2285-95. [PubMed: 21652675] [MGI Ref ID J:176939]
Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N. 2011. BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS. J Biol Chem 286(16):13905-13. [PubMed: 21367852] [MGI Ref ID J:171123]
Leon C; Eckly A; Hechler B; Aleil B; Freund M; Ravanat C; Jourdain M; Nonne C; Weber J; Tiedt R; Gratacap MP; Severin S; Cazenave JP; Lanza F; Skoda R; Gachet C. 2007. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood 110(9):3183-91. [PubMed: 17664350] [MGI Ref ID J:148233]
Martin V; Guillermet-Guibert J; Chicanne G; Cabou C; Jandrot-Perrus M; Plantavid M; Vanhaesebroeck B; Payrastre B; Gratacap MP. 2010. Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo. Blood 115(10):2008-13. [PubMed: 20065293] [MGI Ref ID J:158839]
Meyer A; Wang W; Qu J; Croft L; Degen JL; Coller BS; Ahamed J. 2012. Platelet TGF-beta1 contributions to plasma TGF-beta1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood 119(4):1064-74. [PubMed: 22134166] [MGI Ref ID J:181748]
Mitsios JV; Prevost N; Kasirer-Friede A; Gutierrez E; Groisman A; Abrams CS; Wang Y; Litvinov RI; Zemljic-Harpf A; Ross RS; Shattil SJ. 2010. What is vinculin needed for in platelets? J Thromb Haemost 8(10):2294-304. [PubMed: 20670372] [MGI Ref ID J:182427]
Osada M; Inoue O; Ding G; Shirai T; Ichise H; Hirayama K; Takano K; Yatomi Y; Hirashima M; Fujii H; Suzuki-Inoue K; Ozaki Y. 2012. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem 287(26):22241-52. [PubMed: 22556408] [MGI Ref ID J:187533]
Pawlinski R; Wang JG; Owens AP 3rd; Williams J; Antoniak S; Tencati M; Luther T; Rowley JW; Low EN; Weyrich AS; Mackman N. 2010. Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood 116(5):806-14. [PubMed: 20410508] [MGI Ref ID J:163510]
Pericacho M; Alonso-Martin S; Larrucea S; Gonzalez-Manchon C; Fernandez D; Sanchez I; Ayuso MS; Parrilla R. 2011. Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes. PLoS One 6(10):e26025. [PubMed: 22016802] [MGI Ref ID J:178107]
Petrich BG; Marchese P; Ruggeri ZM; Spiess S; Weichert RA; Ye F; Tiedt R; Skoda RC; Monkley SJ; Critchley DR; Ginsberg MH. 2007. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204(13):3103-11. [PubMed: 18086863] [MGI Ref ID J:129707]
Pleines I; Eckly A; Elvers M; Hagedorn I; Eliautou S; Bender M; Wu X; Lanza F; Gachet C; Brakebusch C; Nieswandt B. 2010. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood 115(16):3364-73. [PubMed: 20139097] [MGI Ref ID J:160792]
Pleines I; Hagedorn I; Gupta S; May F; Chakarova L; van Hengel J; Offermanns S; Krohne G; Kleinschnitz C; Brakebusch C; Nieswandt B. 2012. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 119(4):1054-63. [PubMed: 22045984] [MGI Ref ID J:181662]
Randriamboavonjy V; Isaak J; Elgheznawy A; Pistrosch F; Fromel T; Yin X; Badenhoop K; Heide H; Mayr M; Fleming I. 2012. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. Blood 120(2):415-23. [PubMed: 22665935] [MGI Ref ID J:189100]
Smith EC; Thon JN; Devine MT; Lin S; Schulz VP; Guo Y; Massaro SA; Halene S; Gallagher P; Italiano JE Jr; Krause DS. 2012. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood 120(11):2317-29. [PubMed: 22806889] [MGI Ref ID J:189155]
Wang Y; Litvinov RI; Chen X; Bach TL; Lian L; Petrich BG; Monkley SJ; Critchley DR; Sasaki T; Birnbaum MJ; Weisel JW; Hartwig J; Abrams CS. 2008. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest 118(2):812-9. [PubMed: 18188447] [MGI Ref ID J:131289]
Wen Q; Leung C; Huang Z; Small S; Reddi AL; Licht JD; Crispino JD. 2009. Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood 114(1):153-6. [PubMed: 19339696] [MGI Ref ID J:150314]
Ye S; Karim ZA; Al Hawas R; Pessin JE; Filipovich AH; Whiteheart SW. 2012. Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood 120(12):2484-92. [PubMed: 22767500] [MGI Ref ID J:189176]
Zhang G; Xiang B; Dong A; Skoda RC; Daugherty A; Smyth SS; Du X; Li Z. 2011. Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood 118(13):3670-9. [PubMed: 21803853] [MGI Ref ID J:177066]
Zhang L; Orban M; Lorenz M; Barocke V; Braun D; Urtz N; Schulz C; von Bruhl ML; Tirniceriu A; Gaertner F; Proia RL; Graf T; Bolz SS; Montanez E; Prinz M; Muller A; von Baumgarten L; Billich A; Sixt M; Fassler R; von Andrian UH; Junt T; Massberg S. 2012. A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med 209(12):2165-81. [PubMed: 23148237] [MGI Ref ID J:190861]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MGL377
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice can be bred as homozygotes. Mating System Noncarrier x Hemizygote (Female x Male) 15-JAN-09 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Pf4-cre)Q3Rsko
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(Pf4-cre)Q3Rsko x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(Pf4-cre)Q3Rsko Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Pf4-cre)Q3Rsko
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(Pf4-cre)Q3Rsko x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(Pf4-cre)Q3Rsko Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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