Strain Name:

B6.Cg-Tg(Prnp-Abca1)EHol/J

Stock Number:

008596

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
These transgenic mice, expressing the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse prion protein promoter exhibit an increase in expression of ABCA1 in the cortex and reduction of apoE levels in the hippocampus and cerebrospinal fluid. These mice may be useful in studies of amyloid deposition in the brain and Alzheimers disease.

Description

Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   23-JAN-09
Specieslaboratory mouse
GenerationN5+F13 (08-JUL-14)
Generation Definitions
 
Donating InvestigatorDr. David M. Holtzman,   Washington University

Description
These transgenic mice express the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter.

These founder line E mice have a 6-fold increase in expression of ABCA1 in the cortex over wild-type levels. Trangene expression is high in total brain tissue, kidney, testis and muscle as detected by Western blot analysis. Transgenic mice exhibit reduced apoE levels: 40% of wild-type levels in the hippocampus, approximately half of wild-type levels in cerebrospinal fluid (CSF). The apoE protein that is overexpressed has altered biochemical properties and is not as soluble as that found in controls. Lipoprotein particles from the CSF that contain apoE protein are larger in size than wild-type, indicating that the transgenic apoE particles are more lipidated.

Male transgenic mice have atropied testes, defective spermatogenesis and are infertile. The strain can be maintained by mating hemizygous females to wild-type males.

These mice may be useful in studies of the underlying mechanism of amyloid deposition in the brain and Alzheimers disease.

Development
A transgenic construct containing the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter was injected into fertilized B6CBAF1 eggs. Founder line E was subsequently established. The mice were backcrossed to C57BL/6 (see SNP notes below) for four generations. After arriving at The Jackson Laboratory, the mice were backcrossed to C57BL/6J for one generation.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on transgenic expression of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
ATP-Binding Cassette, Subfamily A, Member 1; ABCA1   (ABCA1)
Hypercholesterolemia, Familial   (ABCA1)
Hypoalphalipoproteinemia, Primary   (ABCA1)
Tangier Disease; TGD   (ABCA1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tg(Prnp-Abca1)EHol/0

        involves: C57BL/6 * CBA
  • reproductive system phenotype
  • abnormal spermatogenesis
    • elongated spermatids and spermatozoa are absent in testes of mutant males   (MGI Ref ID J:131400)
  • abnormal testis morphology
    • 3-fold increased numbers of apoptotic cells in testes relative to controls   (MGI Ref ID J:131400)
    • abnormal testis development
      • testes exhibit maturation arrest due to absence of mature products of spermatogenesis   (MGI Ref ID J:131400)
    • decreased testis weight
      • 50% reduction in testes mass relative to wild-type controls   (MGI Ref ID J:131400)
    • seminiferous tubule degeneration
      • tubules display atrophy with marked degenerative changes such as large increase in multinucleated giant cells and cells with condensed nuclei   (MGI Ref ID J:131400)
    • testicular atrophy
      • severe atrophy   (MGI Ref ID J:131400)
  • male infertility   (MGI Ref ID J:131400)
  • nervous system phenotype
  • abnormal glial cell physiology
    • Apoe-containing lipoprotein particles secreted by astrocytes contain more lipid than those secreted by non-transgenic controls; lipoprotein fractions contain a greater ratio of cholesterol to Apoe   (MGI Ref ID J:131400)
  • amyloid beta deposits
    • in 12-month old mice have frequent amyloid beta (Abeta) deposits in cortex and hippocampus including molecular layer of hippocampus   (MGI Ref ID J:131400)
    • almost no deposits are observed in hilus of dentate gyrus of hippocampus   (MGI Ref ID J:131400)
    • thioflavin-S positive fibrillar Abeta plaques are frequently observed in cortex and hippocampus at 12 months   (MGI Ref ID J:131400)
    • thioflavin-S positive plaques are associated with reactive microglia   (MGI Ref ID J:131400)
  • endocrine/exocrine gland phenotype
  • abnormal testis morphology
    • 3-fold increased numbers of apoptotic cells in testes relative to controls   (MGI Ref ID J:131400)
    • abnormal testis development
      • testes exhibit maturation arrest due to absence of mature products of spermatogenesis   (MGI Ref ID J:131400)
    • decreased testis weight
      • 50% reduction in testes mass relative to wild-type controls   (MGI Ref ID J:131400)
    • seminiferous tubule degeneration
      • tubules display atrophy with marked degenerative changes such as large increase in multinucleated giant cells and cells with condensed nuclei   (MGI Ref ID J:131400)
    • testicular atrophy
      • severe atrophy   (MGI Ref ID J:131400)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • plasma levels of cholesterol including HDL-associated cholesterol and phospolipids, and Apoe are not significantly different from controls at 3 months   (MGI Ref ID J:131400)
    • abnormal protein level
      • mice show 40% reduction in Apoe levels in hippocampus at 3 months; in CSF, levels of Apoe are decreased >40%   (MGI Ref ID J:131400)
      • brain lysates contain significantly lower levels of Clusterin than control samples   (MGI Ref ID J:131400)
    • amyloid beta deposits
      • in 12-month old mice have frequent amyloid beta (Abeta) deposits in cortex and hippocampus including molecular layer of hippocampus   (MGI Ref ID J:131400)
      • almost no deposits are observed in hilus of dentate gyrus of hippocampus   (MGI Ref ID J:131400)
      • thioflavin-S positive fibrillar Abeta plaques are frequently observed in cortex and hippocampus at 12 months   (MGI Ref ID J:131400)
      • thioflavin-S positive plaques are associated with reactive microglia   (MGI Ref ID J:131400)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease

Reproductive Biology Research
Fertility Defects
      males only

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Prnp-Abca1)EHol
Allele Name transgene insertion E, David M Holtzman
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) PrP-mAbca1 line E;
Mutation Made ByDr. David Holtzman,   Washington University
Strain of Origin(C57BL/6 x CBA)F1
Expressed Gene Abca1, ATP-binding cassette, sub-family A (ABC1), member 1, mouse, laboratory
Promoter Prnp, prion protein, mouse, laboratory
Molecular Note A transgenic construct containing the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter was injected into fertilized B6CBAF1 eggs. Founder line E was subsequently established. These founder line E mice have a 6-fold increase in expression of ABCA1 in the cortex over wildtype levels. Transgene expression is high in total brain tissue, kidney, testis and muscle as detected by Western blot analysis. [MGI Ref ID J:131400]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Prnp-Abca1), Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Wahrle SE; Jiang H; Parsadanian M; Kim J; Li A; Knoten A; Jain S; Hirsch-Reinshagen V; Wellington CL; Bales KR; Paul SM; Holtzman DM. 2008. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 118(2):671-82. [PubMed: 18202749]  [MGI Ref ID J:131400]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Breeding & Husbandry When maintaining a live colony, these transgenic mice can be bred by mating female hemizygote to a wildtype male. Male transgenic mice are sterile.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   23-JAN-09

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Prnp-Abca1)EHol  
Price per Pair (US dollars $)Pair Genotype
$311.00Hemizygous for Tg(Prnp-Abca1)EHol x Noncarrier  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Prnp-Abca1)EHol  
Price per Pair (US dollars $)Pair Genotype
$404.30Hemizygous for Tg(Prnp-Abca1)EHol x Noncarrier  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Noncarrier
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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General Terms and Conditions


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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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