Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.C-Cacngstg-3J/LetJ    (Changed: 27-AUG-08 ) Type Congenic; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse H2 Haplotype b Generation N10F6pN1 Generation Definitions

Description
Homozygotes for the stargazer 3 Jackson allele exhibit a much milder phenotype than mice homozygous for the stargazer allele. Mice are identified at 3-4 weeks by an ataxic gait. Although EEG readings show no spike wave discharge, absence seizures are observed. (personal communication) This strain may be useful in studies of epilepsy and voltage-dependent calcium channels.

Development
This spontaneous mutation arose on BALB/cJ in the production colonies of The Jackson Laboratory. It was backcrossed a minimum of ten generations to C57BL/6J in the laboratory of Dr. Wayne Frankel and Dr. Verity Letts and donated to the Repository in 2008.

Related Strains

Strains carrying other alleles of Cacng2

001883	B6.MRL-Cacng2stg-wag/J
001756	B6C3Fe a/a-Cacng2stg/J

View Strains carrying other alleles of Cacng2     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Cacng2^stg-3J/Cacng2^stg-3J

        B6C3-Cacng2^stg-3J/J

• nervous system phenotype
• *normal* nervous system phenotype
  • no seizure activity was detected   (MGI Ref ID J:96506)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cell Biology Research
Channel and Transporter Defects
      calcium

Neurobiology Research
Ataxia (Movement) Defects
Channel and Transporter Defects
      calcium
      calcium: glutamate receptor

Cacng2^stg-3J related

Neurobiology Research
Ataxia (Movement) Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Cacng2stg-3J
Allele Name		stargazer 3 Jackson
Allele Type		Spontaneous
Strain of Origin		BALB/cJ
Gene Symbol and Name		Cacng2, calcium channel, voltage-dependent, gamma subunit 2
Chromosome		15
Gene Common Name(s)		AW060990; B230105C07Rik; B930041E13Rik; Ipr328; MRD10; RIKEN cDNA B230105C07 gene; RIKEN cDNA B930041E13 gene; TARP gamma 2; expressed sequence AW060990; stargazer; stargazin; stg; wag; waggler;
Molecular Note		The phenotype of the stargazer 3J mouse has been attributed to an early transposon (ETn) insertion into intron 2, approximately 2 kb downstream from the site of the ETn insertion that gave rise to the original stargazer mutation. RT-PCR analysis demonstrated that in addition to two aberrant transcripts generated by the insertion, some normally spliced mRNA was detected, suggesting that this mutation does not represent a complete null allele. [MGI Ref ID J:84624]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Inokuchi K; Dan K; Takatori M; Takahuji H; Uchida N; Inami M; Miyake K; Honda H; Hirai H; Shimada T. 2003. Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis. Blood 102(1):320-3. [PubMed: 12623846]  [MGI Ref ID J:84626]

Additional References

Cacng2^stg-3J related

Letts VA; Kang MG; Mahaffey CL; Beyer B; Tenbrink H; Campbell KP; Frankel WN. 2003. Phenotypic heterogeneity in the stargazin allelic series. Mamm Genome 14(8):506-13. [PubMed: 12925883]  [MGI Ref ID J:84624]

Letts VA; Mahaffey CL; Beyer B; Frankel WN. 2005. A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice. Proc Natl Acad Sci U S A 102(6):2123-8. [PubMed: 15677329]  [MGI Ref ID J:96506]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice are bred as homozygotes.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Mouse Mutant Resource collection.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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