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| These transgenic mice express Cre recombinase under the direction of the receptor tyrosine kinase Tek (Tie2) promoter/enhancer, which has been shown to provide uniform expression in endothelial cells during embryogenesis and adulthood. | |||||||||||||||||||
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Description
Strain Information
Type Congenic; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 16-JUL-09 Species laboratory mouse Generation N8+F5 (06-OCT-11)
Generation DefinitionsDonating Investigator Dr. Masashi Yanagisawa, Southwestern Medical School Description
These transgenic mice express Cre recombinase under the direction of the receptor tyrosine kinase Tek (Tie2) promoter/enhancer, which has been shown to provide uniform expression in endothelial cells during embryogenesis and adulthood. Mice that are hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity results in the deletion of loxP flanked targets in vascular endothelial cells.Development
Cre cDNA and metallothionein-1 (MT-1) polyA signal sequence was inserted between the mouse Tek (Tie2) promoter and enhancer. The transgenic cassette was injected into B6SJLF1 fertilized oocytes and backcrossed to a C57BL/6 genetic background for at least eight generations by the donating investigator.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Tek
004128 B6.Cg-Tg(Tek-cre)12Flv/J 013196 B6.Cg-Tg(Tie2-B4galnt2)1108Dgi/J 008537 FVB-Tg(Tek-cre)2352Rwng/J 002856 FVB/N-Tg(TIE2-lacZ)182Sato/J 005707 STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J 006770 STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J 003658 STOCK Tg(TIE2GFP)287Sato/J View Strains carrying other alleles of Tek (7 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Tek-cre)1Ywa | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Masashi Yanagisawa | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | T2Cre; TekCre; Tie-2 Cre; Tie2-Cre; Tie2Cre; Tie2Cre+; | ||
| Mutation Made By | Dr. Masashi Yanagisawa, Southwestern Medical School | ||
| Strain of Origin | (C57BL/6 x SJL)F1 | ||
| Site of Expression | uniform expression in endothelial cells during embryogenesis and adulthood. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Tek, endothelial-specific receptor tyrosine kinase, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Tek-cre)1Ywa, transgene insertion 1, Masashi Yanagisawa | ||
| Chromosome | UN | ||
| Gene Common Name(s) | T2Cre; TekCre; Tg(Tek-cre)1Dlg; Tie 2-Cre; Tie-2 Cre; Tie2-Cre; Tie2Cre; Tie2Cre+; transgene insertion 1, Brian R Duling; | ||
| Driver Note | Tek | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a mouse Tek promoter and enhancer. This promoter is active in endothelial cells. [MGI Ref ID J:67365] [MGI Ref ID J:71269] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Kisanuki YY; Hammer RE; Miyazaki J; Williams SC; Richardson JA; Yanagisawa M. 2001. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 230(2):230-42. [PubMed: 11161575] [MGI Ref ID J:67365]
Additional References
Tg(Tek-cre)1Ywa relatedAanhaanen WT; Boukens BJ; Sizarov A; Wakker V; de Gier-de Vries C; van Ginneken AC; Moorman AF; Coronel R; Christoffels VM. 2011. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest 121(2):534-44. [PubMed: 21266775] [MGI Ref ID J:171828]
Abbas A; Imrie H; Viswambharan H; Sukumar P; Rajwani A; Cubbon RM; Gage M; Smith J; Galloway S; Yuldeshava N; Kahn M; Xuan S; Grant PJ; Channon KM; Beech DJ; Wheatcroft SB; Kearney MT. 2011. The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60(8):2169-78. [PubMed: 21677284] [MGI Ref ID J:186813]
Acharya M; Mukhopadhyay S; Paidassi H; Jamil T; Chow C; Kissler S; Stuart LM; Hynes RO; Lacy-Hulbert A. 2010. alphav Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J Clin Invest 120(12):4445-52. [PubMed: 21099114] [MGI Ref ID J:171863]
Aki D; Minoda Y; Yoshida H; Watanabe S; Yoshida R; Takaesu G; Chinen T; Inaba T; Hikida M; Kurosaki T; Saeki K; Yoshimura A. 2008. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Genes Cells 13(2):199-208. [PubMed: 18233961] [MGI Ref ID J:138256]
Allende ML; Yamashita T; Proia RL. 2003. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood 102(10):3665-7. [PubMed: 12869509] [MGI Ref ID J:86450]
Anggrahini DW; Emoto N; Nakayama K; Widyantoro B; Adiarto S; Iwasa N; Nonaka H; Rikitake Y; Kisanuki YY; Yanagisawa M; Hirata K. 2009. Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation. Cardiovasc Res 82(1):143-51. [PubMed: 19164391] [MGI Ref ID J:162199]
Arima Y; Harada M; Kamimura D; Park JH; Kawano F; Yull FE; Kawamoto T; Iwakura Y; Betz UA; Marquez G; Blackwell TS; Ohira Y; Hirano T; Murakami M. 2012. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 148(3):447-57. [PubMed: 22304915] [MGI Ref ID J:181336]
Armulik A; Genove G; Mae M; Nisancioglu MH; Wallgard E; Niaudet C; He L; Norlin J; Lindblom P; Strittmatter K; Johansson BR; Betsholtz C. 2010. Pericytes regulate the blood-brain barrier. Nature 468(7323):557-61. [PubMed: 20944627] [MGI Ref ID J:166532]
Bagnall AJ; Kelland NF; Gulliver-Sloan F; Davenport AP; Gray GA; Yanagisawa M; Webb DJ; Kotelevtsev YV. 2006. Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension 48(2):286-93. [PubMed: 16801484] [MGI Ref ID J:135711]
Balli D; Zhang Y; Snyder J; Kalinichenko VV; Kalin TV. 2011. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Res 71(1):40-50. [PubMed: 21199796] [MGI Ref ID J:167773]
Barata L; Miwa T; Sato S; Kim D; Mohammed I; Song WC. 2013. Deletion of Crry and DAF on Murine Platelets Stimulates Thrombopoiesis and Increases Factor H-Dependent Resistance of Peripheral Platelets to Complement Attack. J Immunol 190(6):2886-95. [PubMed: 23390291] [MGI Ref ID J:193605]
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Boulday G; Blecon A; Petit N; Chareyre F; Garcia LA; Niwa-Kawakita M; Giovannini M; Tournier-Lasserve E. 2009. Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations. Dis Model Mech 2(3-4):168-77. [PubMed: 19259391] [MGI Ref ID J:146210]
Breart B; Ramos-Perez WD; Mendoza A; Salous AK; Gobert M; Huang Y; Adams RH; Lafaille JJ; Escalante-Alcalde D; Morris AJ; Schwab SR. 2011. Lipid phosphate phosphatase 3 enables efficient thymic egress. J Exp Med 208(6):1267-78. [PubMed: 21576386] [MGI Ref ID J:176831]
Cai X; Nomura-Kitabayashi A; Cai W; Yan J; Christoffels VM; Cai CL. 2011. Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2. Dev Biol 360(2):381-90. [PubMed: 21983003] [MGI Ref ID J:178530]
Camerer E; Regard JB; Cornelissen I; Srinivasan Y; Duong DN; Palmer D; Pham TH; Wong JS; Pappu R; Coughlin SR. 2009. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119(7):1871-9. [PubMed: 19603543] [MGI Ref ID J:152547]
Cariboni A; Davidson K; Dozio E; Memi F; Schwarz Q; Stossi F; Parnavelas JG; Ruhrberg C. 2011. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138(17):3723-33. [PubMed: 21828096] [MGI Ref ID J:175836]
Cattelino A; Liebner S; Gallini R; Zanetti A; Balconi G; Corsi A; Bianco P; Wolburg H; Moore R; Oreda B; Kemler R; Dejana E. 2003. The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol 162(6):1111-22. [PubMed: 12975353] [MGI Ref ID J:85505]
Cera MR; Del Prete A; Vecchi A; Corada M; Martin-Padura I; Motoike T; Tonetti P; Bazzoni G; Vermi W; Gentili F; Bernasconi S; Sato TN; Mantovani A; Dejana E. 2004. Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest 114(5):729-38. [PubMed: 15343392] [MGI Ref ID J:92592]
Chae SS; Paik JH; Allende ML; Proia RL; Hla T. 2004. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol 268(2):441-7. [PubMed: 15063179] [MGI Ref ID J:92203]
Chakraborty S; Wirrig EE; Hinton RB; Merrill WH; Spicer DB; Yutzey KE. 2010. Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol 347(1):167-79. [PubMed: 20804746] [MGI Ref ID J:165714]
Chan AC; Drakos SG; Ruiz OE; Smith AC; Gibson CC; Ling J; Passi SF; Stratman AN; Sacharidou A; Revelo MP; Grossmann AH; Diakos NA; Davis GE; Metzstein MM; Whitehead KJ; Li DY. 2011. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest 121(5):1871-81. [PubMed: 21490399] [MGI Ref ID J:173947]
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Chang YC; Wang Z; Flax LA; Xu D; Esko JD; Nizet V; Baron MJ. 2011. Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog 7(6):e1002082. [PubMed: 21731486] [MGI Ref ID J:182189]
Chantrathammachart P; Mackman N; Sparkenbaugh E; Wang JG; Parise LV; Kirchhofer D; Key NS; Pawlinski R. 2012. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease. Blood 120(3):636-46. [PubMed: 22661702] [MGI Ref ID J:189104]
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Chen L; Mupo A; Huynh T; Cioffi S; Woods M; Jin C; McKeehan W; Thompson-Snipes L; Baldini A; Illingworth E. 2010. Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189(3):417-24. [PubMed: 20439995] [MGI Ref ID J:159824]
Chhabra A; Lechner AJ; Ueno M; Acharya A; Van Handel B; Wang Y; Iruela-Arispe ML; Tallquist MD; Mikkola HK. 2012. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell 22(3):651-9. [PubMed: 22387002] [MGI Ref ID J:182738]
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Curtis CD; Griffin CT. 2012. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol 32(7):1312-20. [PubMed: 22290435] [MGI Ref ID J:183690]
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Davis RB; Curtis CD; Griffin CT. 2013. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140(6):1272-81. [PubMed: 23406903] [MGI Ref ID J:194470]
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Garmy-Susini B; Avraamides CJ; Schmid MC; Foubert P; Ellies LG; Barnes L; Feral C; Papayannopoulou T; Lowy A; Blair SL; Cheresh D; Ginsberg M; Varner JA. 2010. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res 70(8):3042-51. [PubMed: 20388801] [MGI Ref ID J:158943]
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Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A. 2003. Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol 262(2):225-41. [PubMed: 14550787] [MGI Ref ID J:86207]
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Holtz ML; Misra RP. 2008. Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality. BMC Dev Biol 8:65. [PubMed: 18570667] [MGI Ref ID J:139204]
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Huang J; Davis EC; Chapman SL; Budatha M; Marmorstein LY; Word RA; Yanagisawa H. 2010. Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res 106(3):583-92. [PubMed: 20019329] [MGI Ref ID J:170883]
Huang X; Zhao YY. 2012. Transgenic expression of FoxM1 promotes endothelial repair following lung injury induced by polymicrobial sepsis in mice. PLoS One 7(11):e50094. [PubMed: 23185540] [MGI Ref ID J:195010]
Isermann B; Hendrickson SB; Zogg M; Wing M; Cummiskey M; Kisanuki YY; Yanagisawa M; Weiler H. 2001. Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J Clin Invest 108(4):537-46. [PubMed: 11518727] [MGI Ref ID J:71269]
Ishizaki T; Tamiya T; Taniguchi K; Morita R; Kato R; Okamoto F; Saeki K; Nomura M; Nojima Y; Yoshimura A. 2011. miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1. Genes Cells 16(7):803-14. [PubMed: 21668589] [MGI Ref ID J:186742]
Ismat FA; Xu J; Lu MM; Epstein JA. 2006. The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest 116(9):2378-84. [PubMed: 16906226] [MGI Ref ID J:114455]
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Tam SJ; Richmond DL; Kaminker JS; Modrusan Z; Martin-McNulty B; Cao TC; Weimer RM; Carano RA; van Bruggen N; Watts RJ. 2012. Death Receptors DR6 and TROY Regulate Brain Vascular Development. Dev Cell 22(2):403-17. [PubMed: 22340501] [MGI Ref ID J:181470]
Tanaka K; Ichiyama K; Hashimoto M; Yoshida H; Takimoto T; Takaesu G; Torisu T; Hanada T; Yasukawa H; Fukuyama S; Inoue H; Nakanishi Y; Kobayashi T; Yoshimura A. 2008. Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol 180(6):3746-56. [PubMed: 18322180] [MGI Ref ID J:132905]
Tang N; Mack F; Haase VH; Simon MC; Johnson RS. 2006. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol 26(7):2519-30. [PubMed: 16537898] [MGI Ref ID J:106926]
Tang N; Wang L; Esko J; Giordano FJ; Huang Y; Gerber HP; Ferrara N; Johnson RS. 2004. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6(5):485-95. [PubMed: 15542432] [MGI Ref ID J:94773]
Tanjore H; Zeisberg EM; Gerami-Naini B; Kalluri R. 2008. Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn 237(1):75-82. [PubMed: 18058911] [MGI Ref ID J:130422]
Tanowitz HB; Huang H; Jelicks LA; Chandra M; Loredo ML; Weiss LM; Factor SM; Shtutin V; Mukherjee S; Kitsis RN; Christ GJ; Wittner M; Shirani J; Kisanuki YY; Yanagisawa M. 2005. Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect Immun 73(4):2496-503. [PubMed: 15784596] [MGI Ref ID J:97201]
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Troadec MB; Warner D; Wallace J; Thomas K; Spangrude GJ; Phillips J; Khalimonchuk O; Paw BH; Ward DM; Kaplan J. 2011. Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood 117(20):5494-502. [PubMed: 21310927] [MGI Ref ID J:173284]
Tsuchiya K; Tanaka J; Shuiqing Y; Welch CL; DePinho RA; Tabas I; Tall AR; Goldberg IJ; Accili D. 2012. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab 15(3):372-81. [PubMed: 22405072] [MGI Ref ID J:182672]
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Van den Bossche J; Lamers WH; Koehler ES; Geuns JM; Alhonen L; Uimari A; Pirnes-Karhu S; Van Overmeire E; Morias Y; Brys L; Vereecke L; De Baetselier P; Van Ginderachter JA. 2012. Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes. J Leukoc Biol 91(5):685-99. [PubMed: 22416259] [MGI Ref ID J:183882]
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Wagner C; Jobs A; Schweda F; Kurtz L; Kurt B; Lopez ML; Gomez RA; van Veen TA; de Wit C; Kurtz A. 2010. Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. Kidney Int 78(8):762-8. [PubMed: 20686449] [MGI Ref ID J:184249]
Wan Y; Chong LW; Evans RM. 2007. PPAR-gamma regulates osteoclastogenesis in mice. Nat Med 13(12):1496-503. [PubMed: 18059282] [MGI Ref ID J:130475]
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Wang L; Fuster M; Sriramarao P; Esko JD. 2005. Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat Immunol 6(9):902-10. [PubMed: 16056228] [MGI Ref ID J:100456]
Wang N; Yang G; Jia Z; Zhang H; Aoyagi T; Soodvilai S; Symons JD; Schnermann JB; Gonzalez FJ; Litwin SE; Yang T. 2008. Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1. Cell Metab 8(6):482-91. [PubMed: 19041764] [MGI Ref ID J:144377]
Wang R; Dillon CP; Shi LZ; Milasta S; Carter R; Finkelstein D; McCormick LL; Fitzgerald P; Chi H; Munger J; Green DR. 2011. The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Immunity 35(6):871-82. [PubMed: 22195744] [MGI Ref ID J:179281]
Wang Y; Jobe SM; Ding X; Choo H; Archer DR; Mi R; Ju T; Cummings RD. 2012. Platelet biogenesis and functions require correct protein O-glycosylation. Proc Natl Acad Sci U S A 109(40):16143-8. [PubMed: 22988088] [MGI Ref ID J:190114]
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Wareing S; Mazan A; Pearson S; Gottgens B; Lacaud G; Kouskoff V. 2012. The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development. Stem Cells 30(7):1521-31. [PubMed: 22570122] [MGI Ref ID J:194572]
Watt AJ; Battle MA; Li J; Duncan SA. 2004. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U S A 101(34):12573-8. [PubMed: 15310850] [MGI Ref ID J:92434]
Wei G; Srinivasan R; Cantemir-Stone CZ; Sharma SM; Santhanam R; Weinstein M; Muthusamy N; Man AK; Oshima RG; Leone G; Ostrowski MC. 2009. Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114(5):1123-30. [PubMed: 19411629] [MGI Ref ID J:151187]
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Wei W; Wang X; Yang M; Smith LC; Dechow PC; Wan Y. 2010. PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab 11(6):503-16. [PubMed: 20519122] [MGI Ref ID J:160910]
Wei W; Zeve D; Suh JM; Wang X; Du Y; Zerwekh JE; Dechow PC; Graff JM; Wan Y. 2011. Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by beta-Catenin. Mol Cell Biol 31(23):4706-19. [PubMed: 21876000] [MGI Ref ID J:178340]
Weinstein MM; Yin L; Beigneux AP; Davies BS; Gin P; Estrada K; Melford K; Bishop JR; Esko JD; Dallinga-Thie GM; Fong LG; Bensadoun A; Young SG. 2008. Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice. J Biol Chem 283(50):34511-8. [PubMed: 18845532] [MGI Ref ID J:144413]
Weskamp G; Mendelson K; Swendeman S; Le Gall S; Ma Y; Lyman S; Hinoki A; Eguchi S; Guaiquil V; Horiuchi K; Blobel CP. 2010. Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res 106(5):932-40. [PubMed: 20110534] [MGI Ref ID J:170866]
Wessels A; van den Hoff MJ; Adamo RF; Phelps AL; Lockhart MM; Sauls K; Briggs LE; Norris RA; van Wijk B; Perez-Pomares JM; Dettman RW; Burch JB. 2012. Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol 366(2):111-24. [PubMed: 22546693] [MGI Ref ID J:185565]
Whitehead KJ; Chan AC; Navankasattusas S; Koh W; London NR; Ling J; Mayo AH; Drakos SG; Marchuk DA; Davis GE; Li DY. 2009. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med 15(2):177-84. [PubMed: 19151728] [MGI Ref ID J:146527]
Widyantoro B; Emoto N; Nakayama K; Anggrahini DW; Adiarto S; Iwasa N; Yagi K; Miyagawa K; Rikitake Y; Suzuki T; Kisanuki YY; Yanagisawa M; Hirata K. 2010. Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 121(22):2407-18. [PubMed: 20497976] [MGI Ref ID J:174045]
Woodfin A; Reichel CA; Khandoga A; Corada M; Voisin MB; Scheiermann C; Haskard DO; Dejana E; Krombach F; Nourshargh S. 2007. JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood 110(6):1848-56. [PubMed: 17505016] [MGI Ref ID J:146412]
Woodfin A; Voisin MB; Beyrau M; Colom B; Caille D; Diapouli FM; Nash GB; Chavakis T; Albelda SM; Rainger GE; Meda P; Imhof BA; Nourshargh S. 2011. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol 12(8):761-9. [PubMed: 21706006] [MGI Ref ID J:174437]
Wu B; Wang Y; Lui W; Langworthy M; Tompkins KL; Hatzopoulos AK; Baldwin HS; Zhou B. 2011. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Circ Res 109(2):183-92. [PubMed: 21597012] [MGI Ref ID J:185683]
Xie L; Hoffmann AD; Burnicka-Turek O; Friedland-Little JM; Zhang K; Moskowitz IP. 2012. Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell 23(2):280-91. [PubMed: 22898775] [MGI Ref ID J:187715]
Xin M; Small EM; van Rooij E; Qi X; Richardson JA; Srivastava D; Nakagawa O; Olson EN. 2007. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A 104(19):7975-80. [PubMed: 17468400] [MGI Ref ID J:121577]
Xu D; Fuster MM; Lawrence R; Esko JD. 2011. Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem 286(1):737-45. [PubMed: 20974861] [MGI Ref ID J:167553]
Xu H; Morishima M; Wylie JN; Schwartz RJ; Bruneau BG; Lindsay EA; Baldini A. 2004. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 131(13):3217-27. [PubMed: 15175244] [MGI Ref ID J:91013]
Xu W; Carr T; Ramirez K; McGregor S; Sigvardsson M; Kee BL. 2013. E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment. Blood 121(9):1534-42. [PubMed: 23297135] [MGI Ref ID J:194759]
Yao L; Yokota T; Xia L; Kincade PW; McEver RP. 2005. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood 106(13):4093-101. [PubMed: 16118327] [MGI Ref ID J:124059]
Ye X; Wang Y; Cahill H; Yu M; Badea TC; Smallwood PM; Peachey NS; Nathans J. 2009. Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139(2):285-98. [PubMed: 19837032] [MGI Ref ID J:154020]
Ye X; Wang Y; Rattner A; Nathans J. 2011. Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney. Development 138(6):1161-72. [PubMed: 21343368] [MGI Ref ID J:170839]
Yim SH; Shah Y; Tomita S; Morris HD; Gavrilova O; Lambert G; Ward JM; Gonzalez FJ. 2006. Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology 44(3):550-60. [PubMed: 16941684] [MGI Ref ID J:137256]
Yoshimura T; Takeda A; Hamano S; Miyazaki Y; Kinjyo I; Ishibashi T; Yoshimura A; Yoshida H. 2006. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol 177(8):5377-85. [PubMed: 17015723] [MGI Ref ID J:139438]
You LR; Lin FJ; Lee CT; DeMayo FJ; Tsai MJ; Tsai SY. 2005. Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435(7038):98-104. [PubMed: 15875024] [MGI Ref ID J:98247]
Yu Y; Ricciotti E; Scalia R; Tang SY; Grant G; Yu Z; Landesberg G; Crichton I; Wu W; Pure E; Funk CD; FitzGerald GA. 2012. Vascular COX-2 modulates blood pressure and thrombosis in mice. Sci Transl Med 4(132):132ra54. [PubMed: 22553252] [MGI Ref ID J:186669]
Zeini M; Hang CT; Lehrer-Graiwer J; Dao T; Zhou B; Chang CP. 2009. Spatial and temporal regulation of coronary vessel formation by calcineurin-NFAT signaling. Development 136(19):3335-45. [PubMed: 19710169] [MGI Ref ID J:153636]
Zhang H; Bosch-Marce M; Shimoda LA; Tan YS; Baek JH; Wesley JB; Gonzalez FJ; Semenza GL. 2008. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 283(16):10892-903. [PubMed: 18281291] [MGI Ref ID J:136548]
Zhang J; Chang JY; Huang Y; Lin X; Luo Y; Schwartz RJ; Martin JF; Wang F. 2010. The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation. Circ Res 107(10):1209-19. [PubMed: 20847311] [MGI Ref ID J:178188]
Zhang J; Lin Y; Zhang Y; Lan Y; Lin C; Moon AM; Schwartz RJ; Martin JF; Wang F. 2008. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 135(21):3611-22. [PubMed: 18832393] [MGI Ref ID J:143443]
Zhang Q; He X; Chen L; Zhang C; Gao X; Yang Z; Liu G. 2012. Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development. J Pathol 228(3):416-28. [PubMed: 22821713] [MGI Ref ID J:188490]
Zhang Y; Li S; Yuan L; Tian Y; Weidenfeld J; Yang J; Liu F; Chokas AL; Morrisey EE. 2010. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev 24(16):1746-57. [PubMed: 20713518] [MGI Ref ID J:163662]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MGL375
Colony Maintenance
Breeding & Husbandry When maintained as a live colony, hemizygotes may be bred. Mating System Noncarrier x Hemizygote (Female x Male) 16-JUL-09 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Tek-cre)1Ywa
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(Tek-cre)1Ywa x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(Tek-cre)1Ywa Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Tek-cre)1Ywa
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(Tek-cre)1Ywa x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(Tek-cre)1Ywa Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Terms of Use
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- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.