Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Darren Moore, Ecole Polytechnique Federale de Lausanne Donating Investigator Ted Dawson, Johns Hopkins Univ School of Medicine Description
Homozygous ROSA26-Syn-E46K mice are viable and fertile, with the E46K missense mutant form of human alpha-synuclein (human E46K α-Syn or SYNE46K; associated with familial Parkinson's disease, dementia, and visual hallucinations) inserted into the Gt(ROSA)26Sor (ROSA26) locus. Widespread expression of human E46K α-Syn is blocked by an upstream loxP-flanked STOP sequence (in the absence of Cre recombinase, no human E46K α-Syn protein is observed in brain regions). When bred to cre expressing mice, the STOP sequence is deleted in the tissues of offspring where Cre recombinase is present; resulting in human E46K α-Syn expression. In particular, Stock No. 008601 B6.Cg-Tg(Th-cre)1Tmd/J may be useful for this application. These ROSA26-Syn-E46K mice allow inducible expression of a human mutation associated with familial Parkinson's disease, dementia, and visual hallucinations and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.Development
A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a human alpha-synuclein cDNA bearing a familial Parkinson's disease-linked E46K missense mutation (SYNE46K), and a bovine polyadenylation signal. This construct was inserted into the Gt(ROSA)26Sor locus via electroporation into into 129/SvJ-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with C57BL/6J mice to generate the mutant colony. ROSA26-Syn-E46K mice were bred to C57BL/6 for 2-3 generations and then bred together to make homozygous prior to arrival at The Jackson Laboratory. Upon arrival, mutant mice were bred with C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.
| Control | ||
|---|---|---|
| 101043 B6129SF1/J | (approximate) | |
| 101045 B6129SF2/J | (approximate) | |
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
Parkinson's Disease Models
005987 129-Achetm1Loc/J 007587 129S-Park2tm1Rpa/J 002779 129S-Parp1tm1Zqw/J 016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 004608 B6(Cg)-Htra2mnd2/J 008133 B6.129-Sncbtm1Sud/J 008084 B6.129P2-Drd4tm1Dkg/J 004744 B6.129P2-Esr1tm1Ksk/J 013586 B6.129P2-Gt(ROSA)26Sortm1Nik/J 002609 B6.129P2-Nos2tm1Lau/J 008843 B6.129P2-Sncgtm1Vlb/J 016566 B6.129S-Hcn1tm2Kndl/J 004322 B6.129S1-Mapk10tm1Flv/J 003190 B6.129S2-Drd2tm1Low/J 006582 B6.129S4-Park2tm1Shn/J 005934 B6.129S4-Ucp2tm1Lowl/J 004936 B6.129S6(Cg)-Spp1tm1Blh/J 012453 B6.129X1(FVB)-Lrrk2tm1.1Cai/J 017009 B6.129X1-Nfe2l2tm1Ywk/J 009346 B6.Cg-Lrrk2tm1.1Shn/J 005491 B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 006577 B6.Cg-Park7tm1Shn/J 000567 B6.Cg-T2J +/+ Qkqk-v/J 007004 B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ 003139 B6.Cg-Tg(DBHn-lacZ)8Rpk/J 007673 B6.Cg-Tg(Gad1-EGFP)3Gfng/J 012466 B6.Cg-Tg(Lrrk2)6Yue/J 012467 B6.Cg-Tg(Lrrk2*G2019S)2Yue/J 008323 B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J 008321 B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J 008324 B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J 008322 B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J 007894 B6.Cg-Tg(Rgs4-EGFP)4Lvt/J 012588 B6.Cg-Tg(TH-ALPP)1Erav/J 008859 B6.Cg-Tg(THY1-SNCA*A53T)F53Sud/J 008135 B6.Cg-Tg(THY1-SNCA*A53T)M53Sud/J 008601 B6.Cg-Tg(Th-cre)1Tmd/J 013583 B6.Cg-Tg(tetO-LRRK2)C7874Cai/J 000544 B6.D2-Cacna1atg/J 012445 B6.FVB-Tg(LRRK2)WT1Mjfa/J 012446 B6.FVB-Tg(LRRK2*G2019S)1Mjfa/J 006660 B6.SJL-Slc6a3tm1.1(cre)Bkmn/J 008364 B6;129-Chattm1(cre/ERT)Nat/J 009688 B6;129-Dbhtm2(Th)Rpa Thtm1Rpa/J 008883 B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ 008889 B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ 009347 B6;129-Lrrk2tm1.1Shn/J 016209 B6;129-Lrrk2tm2.1Shn/J 016210 B6;129-Lrrk2tm3.1Shn/J 013050 B6;129-Pink1tm1Aub/J 004807 B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax 006390 B6;129-Sncatm1Sud Sncbtm1.1Sud/J 008532 B6;129-Thtm1(cre/Esr1)Nat/J 008333 B6;129P2-Dldtm1Ptl/J 008333 B6;129P2-Dldtm1Ptl/J 002596 B6;129P2-Nos2tm1Lau/J 003243 B6;129S-Tnfrsf1atm1Imx Tnfrsf1btm1Imx/J 003692 B6;129X1-Sncatm1Rosl/J 016575 B6;C3-Tg(PDGFB-LRRK2*G2019S)340Djmo/J 016576 B6;C3-Tg(PDGFB-LRRK2*R1441C)574Djmo/J 008169 B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J 004479 B6;C3-Tg(Prnp-SNCA*A53T)83Vle/J 000231 B6;C3Fe a/a-Csf1op/J 013725 B6;SJL-Tg(LRRK2)66Youy/J 016555 B6;SJL-Tg(Nqo1-ALPP)1Jaj/J 008473 B6;SJL-Tg(THY1-SNCA*A30P)M30Sud/J 008134 B6;SJL-Tg(THY1-SNCA*A30P)TS2Sud/J 016976 B6C3-Tg(tetO-SNCA*A53T)33Vle/J 000506 B6C3Fe a/a-Qkqk-v/J 003741 B6D2-Tg(Prnp-MAPT)43Vle/J 012621 C.129S(B6)-Chrna3tm1.1Hwrt/J 008389 C57BL/6-Tg(THY1-SNCA)1Sud/J 012769 C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J 005706 C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 008245 C57BL/6J-Tg(Th-SNCA)5Eric/J 008239 C57BL/6J-Tg(Th-SNCA*A30P*A53T)39Eric/J 012441 C57BL/6J-Tg(tetO-LRRK2*G2019S)E3Cai/J 012450 C57BL/6J-Tg(tetO-SNCA)1Cai/J 016120 C57BL/6N-Lrrk1tm1.1Youy/J 016121 C57BL/6N-Lrrk2tm1.1Youy/J 016936 C57BL/6N-Tg(Thy1-SNCA)12Youy/J 017682 C57BL/6N-Tg(Thy1-SNCA)15Youy/J 007677 CB6-Tg(Gad1-EGFP)G42Zjh/J 009610 FVB/N-Tg(LRRK2)1Cjli/J 009609 FVB/N-Tg(LRRK2*G2019S)1Cjli/J 009604 FVB/N-Tg(LRRK2*R1441G)135Cjli/J 009090 FVB/NJ-Tg(Slc6a3-PARK2*Q311X)AXwy/J 010710 FVB;129S6-Sncatm1Nbm Tg(SNCA)1Nbm/J 010788 FVB;129S6-Sncatm1Nbm Tg(SNCA*A30P)1Nbm Tg(SNCA*A30P)2Nbm/J 010799 FVB;129S6-Sncatm1Nbm Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/J 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J 000942 STOCK Pitx3ak/2J 014092 STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J 006340 STOCK Tg(Gad1-EGFP)98Agmo/J 008474 STOCK Tg(THY1-SNCA*A53T)F53Sud/J 008132 STOCK Tg(THY1-Snca)M1mSud/J 012442 STOCK Tg(tetO-SNCA*A53T)E2Cai/J 012449 STOCK Tg(teto-LRRK2)C7874Cai/J View Parkinson's Disease Models (99 strains)
Strains carrying other alleles of Gt(ROSA)26Sor
002292 129-Gt(ROSA)26Sor/J 006053 129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J 006067 129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J 006041 129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J 003310 129S-Gt(ROSA)26Sortm1Sor/J 009043 129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J 007844 129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J 003946 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J 007689 129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J 017626 B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J 010633 B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J 008242 B6(Cg)-Gt(ROSA)26Sortm1(Ikbkb)Rsky/J 007676 B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J 006071 B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J 007708 B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J 008463 B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J 008606 B6.129-Gt(ROSA)26Sortm1Joe/J 006080 B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J 006075 B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J 011008 B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J 009669 B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J 008513 B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J 013586 B6.129P2-Gt(ROSA)26Sortm1Nik/J 013587 B6.129P2-Gt(ROSA)26Sortm3Nik/J 009086 B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/RainJ 003474 B6.129S4-Gt(ROSA)26Sortm1Sor/J 012930 B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J 009044 B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J 007743 B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J 009673 B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J 002192 B6.129S7-Gt(ROSA)26Sor/J 006148 B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J 014588 B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1A1tm6(tetO-MSI2)Jae/J 006965 B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J 005670 B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J 007914 B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J 007920 B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J 012567 B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J 007903 B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J 014648 B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ 007906 B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J 007909 B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J 007897 B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J 017455 B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J 010527 B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J 016262 B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J 008883 B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ 004847 B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J 006911 B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J 008516 B6;129-Gt(ROSA)26Sortm1Joe/J 003504 B6;129-Gt(ROSA)26Sortm1Sho/J 008889 B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ 009253 B6;129-Gt(ROSA)26Sortm2Nat/J 004077 B6;129-Gt(ROSA)26Sortm2Sho/J 010557 B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J 010523 B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J 002073 B6;129S-Gt(ROSA)26Sor/J 012569 B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J 012570 B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J 012735 B6;129S-Gt(ROSA)26Sortm35.1(CAG-AOP3/GFP)Hze/J 014538 B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J 014539 B6;129S-Gt(ROSA)26Sortm39(CAG-HOP/EYFP)Hze/J 016836 B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J 003309 B6;129S4-Gt(ROSA)26Sortm1Sor/J 004598 B6;129S4-Gt(ROSA)26Sortm2Dym/J 007670 B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J 016999 B6;129S6-Gt(ROSA)26Sortm1(xstpx-rtTA2S*M2)Whsu/J 007908 B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J 007905 B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J 009670 C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J 008603 C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J 002955 C.129S7-Gt(ROSA)26Sor/J 007900 C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J 008517 C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J 012637 C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J 012638 C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J 012343 C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J 012352 C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J 012361 C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J 005420 C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/J 008040 CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J 007898 CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J 009427 FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J 005125 FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J 006206 FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J 012429 FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J 010920 FVB;129P2-Gt(ROSA)26Sortm1(birA)Mejr/J 016603 NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ 013731 STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J 006331 STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J 008159 STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J 005130 STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J 011004 STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J 011011 STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J 011013 STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J 005572 STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J 008600 STOCK Gt(ROSA)26Sortm1(tTA)Roos/J 013124 STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J 007576 STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J 009674 STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J 012266 STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J 013123 STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J 007577 STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J 007896 STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J View Strains carrying other alleles of Gt(ROSA)26Sor (104 strains)
Introduction to Cre-lox technology
Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.
View Mammalian Phenotype Terms
Mammalian Phenotype Terms provided by MGI
assigned by genotype
Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/Gt(ROSA)26Sortm3(SNCA*E46K)Djmo
involves: 129 * C57BL/6J
- normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile (MGI Ref ID J:147333)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Ataxia (Movement) Defects
Cre-lox System
loxP-flanked Sequences
Neurodegeneration
Neurotransmitter Receptor and Synaptic Vesicle Defects
Parkinson's Disease
synuclein mutants
Research Tools
Cre-lox System
loxP-flanked Sequences
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Neurobiology Research
| Allele Symbol | Gt(ROSA)26Sortm3(SNCA*E46K)Djmo | ||
|---|---|---|---|
| Allele Name | Targeted mutation 3, Darren Moore | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | ROSA26-Syn-E46K; ROSA26-SynE46KTg; | ||
| Mutation Made By | Darren Moore, Ecole Polytechnique Federale de Lausanne | ||
| Strain of Origin | 129 | ||
| ES Cell Line Name | Other (see notes) | ||
| ES Cell Line Strain | 129 | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| General Note | Authors state that 129/SvJ-derived embryonic stem cells were used. | ||
| Molecular Note | A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a human alpha-synuclein cDNA bearing a familial Parkinson's disease-linked E46K missense mutation (SYNE46K), and a bovine polyadenylation signal. [MGI Ref ID J:147333] [MGI Ref ID J:150777] | ||
Daher JP; Ying M; Banerjee R; McDonald RS; Dumas Hahn M; Yang L; Beal MF; Thomas B; Dawson VL; Dawson TM; Moore DJ. 2009. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Mol Neurodegener 4(1):34. [PubMed: 19630976] [MGI Ref ID J:150777]
Gt(ROSA)26Sortm3(SNCA*E46K)Djmo relatedMoore D. 2009. Generation of a conditional knockin allele expressing the human alpha-synuclein sequence with the E46K mutation MGI Direct Data Submission :. [MGI Ref ID J:147333]
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred together.
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
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Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
| Control | ||
|---|---|---|
| 101043 B6129SF1/J | (approximate) | |
| 101045 B6129SF2/J | (approximate) | |
| 000664 C57BL/6J | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
| phone: | 207-288-6470 |
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MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.