Strain Name:

B6;129-C3tm1Crr Man2a1tm1Jxm/J

Stock Number:


Order this mouse


Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
These C3 (complement component 3) and Man2a1 (mannosidase 2, alpha 1) compound mutant animals develop an autoimmune disease similar to human systemic lupus erythematosus (SLE). As the mice age, symptoms that begin to appear include a rise in anti-nuclear antibody (ANA) titers, abnormal hematology characterized as dyserythropoietic anemia, and nephritis.


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Donating Investigator Jamey D Marth,   Burnham Inst at Univ Calif Santa Barbara

Related Strains

Strains carrying   C3tm1Crr allele
003641   B6;129S4-C3tm1Crr/J
View Strains carrying   C3tm1Crr     (1 strain)

Strains carrying other alleles of C3
000833   B6.SJL-C3c/J
000944   B6.SJL-H2b C3c/2CyJ
000966   B6.SJL-H2s C3c/1CyJ
022098   B6N(Cg)-C3tm1.1(KOMP)Vlcg/J
012261   CBA.129S4(B6)-C3tm1Hrc/Mmjax
012301   D2.129S4(B6)-C3tm1Hrc/Mmjax
View Strains carrying other alleles of C3     (6 strains)

Strains carrying other alleles of Man2a1
006885   B6;129-Man2a1tm2Jxm/J
View Strains carrying other alleles of Man2a1     (1 strain)


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Complement Component 3 Deficiency, Autosomal Recessive; C3D   (C3)
Hemolytic Uremic Syndrome, Atypical, Susceptibility to, 5; AHUS5   (C3)
Macular Degeneration, Age-Related, 9; ARMD9   (C3)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hematological Research

Immunology, Inflammation and Autoimmunity Research
      anti-nuclear antibodies
      lupus erythematosus

Internal/Organ Research
Kidney Defects

C3tm1Crr related

Developmental Biology Research
Lymphoid Tissue Defects
      hematopoietic defects

Immunology, Inflammation and Autoimmunity Research
      specific complement deficiency
Immunodeficiency Associated with Other Defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      specific complement deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol C3tm1Crr
Allele Name targeted mutation 1, Michael C Carroll
Allele Type Targeted (Null/Knockout)
Common Name(s) C3-; C3tm1Crr; mC3-;
Mutation Made By Michael Carroll,   The Center for Blood Research
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name C3, complement component 3
Chromosome 17
Gene Common Name(s) AHUS5; AI255234; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p; Plp; acylation stimulating protein; complement factor 3; expressed sequence AI255234;
Molecular Note Insertion of a PGK-neomycin resistance cassette into an exon of the C3 gene deleted sequences that code for the C-terminal region of the beta chain and the N-terminal region of the alpha chain, including the site for processing the pro-C3 molecule. ELISAtesting did not detect C3 protein in serum of homozygous mutant mice. A C3 hemolytic assay did not detect functional C3 activity. [MGI Ref ID J:30152]
Allele Symbol Man2a1tm1Jxm
Allele Name targeted mutation 1, Jamey Marth
Allele Type Targeted (Null/Knockout)
Common Name(s) alphaM-IIdelta;
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Man2a1, mannosidase 2, alpha 1
Chromosome 17
Gene Common Name(s) AMan II; GOLIM7; MANA2; MANII; Mana-2; Mana2; Manno; Map-2; alpha mannosidase 2;
Molecular Note Homologous recombination inserted a floxed neomycin-thymidine kinase expression cassette downstream of the exon that encodes amino acids 236-258, which is part of the lumenal "stem" domain, and introduced an additional loxP site upstream of the exon. Cre-mediated recombination in ES cells excised the exon, intronic sequences, and the neo-tk sequences, leaving a single loxP site in their place. Functional analyses did not detect enzyme activity in Golgi fractions from tissues from homozygous mutant mice. [MGI Ref ID J:41621]


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Green RS; Stone EL; Tenno M; Lehtonen E; Farquhar MG; Marth JD. 2007. Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis. Immunity 27(2):308-20. [PubMed: 17681821]  [MGI Ref ID J:124348]

Additional References

C3tm1Crr related

Abbate M; Zoja C; Corna D; Rottoli D; Zanchi C; Azzollini N; Tomasoni S; Berlingeri S; Noris M; Morigi M; Remuzzi G. 2008. Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury. J Am Soc Nephrol 19(6):1158-67. [PubMed: 18354030]  [MGI Ref ID J:150161]

Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 73(3):597-606. [PubMed: 17196951]  [MGI Ref ID J:119533]

Ankeny DP; Guan Z; Popovich PG. 2009. B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice. J Clin Invest 119(10):2990-9. [PubMed: 19770513]  [MGI Ref ID J:154634]

Atkinson C; Varela JC; Tomlinson S. 2009. Complement-dependent inflammation and injury in a murine model of brain dead donor hearts. Circ Res 105(11):1094-101. [PubMed: 19815824]  [MGI Ref ID J:170147]

Atkinson C; Zhu H; Qiao F; Varela JC; Yu J; Song H; Kindy MS; Tomlinson S. 2006. Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol 177(10):7266-74. [PubMed: 17082645]  [MGI Ref ID J:140616]

Banda NK; Levitt B; Wood AK; Takahashi K; Stahl GL; Holers VM; Arend WP. 2009. Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro. Clin Exp Immunol 159(1):100-8. [PubMed: 19843088]  [MGI Ref ID J:155358]

Banda NK; Takahashi K; Wood AK; Holers VM; Arend WP. 2007. Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway. J Immunol 179(6):4101-9. [PubMed: 17785849]  [MGI Ref ID J:152026]

Baruah P; Simpson E; Dumitriu IE; Derbyshire K; Coe D; Addey C; Dyson J; Chai JG; Cook T; Scott D; Botto M. 2010. Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol 40(6):1758-67. [PubMed: 20213737]  [MGI Ref ID J:160952]

Baudino L; Fossati-Jimack L; Chevalley C; Martinez-Soria E; Shulman MJ; Izui S. 2007. IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. Blood 109(12):5355-62. [PubMed: 17317854]  [MGI Ref ID J:145432]

Baudino L; Nimmerjahn F; Azeredo da Silveira S; Martinez-Soria E; Saito T; Carroll M; Ravetch JV; Verbeek JS; Izui S. 2008. Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. J Immunol 180(3):1948-53. [PubMed: 18209093]  [MGI Ref ID J:131620]

Baudino L; Sardini A; Ruseva MM; Fossati-Jimack L; Cook HT; Scott D; Simpson E; Botto M. 2014. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A 111(4):1503-8. [PubMed: 24474777]  [MGI Ref ID J:206648]

Bauer EM; Zheng H; Comhair S; Erzurum S; Billiar TR; Bauer PM. 2011. Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One 6(12):e28578. [PubMed: 22194859]  [MGI Ref ID J:182250]

Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111]  [MGI Ref ID J:120524]

Bergthaler A; Flatz L; Verschoor A; Hegazy AN; Holdener M; Fink K; Eschli B; Merkler D; Sommerstein R; Horvath E; Fernandez M; Fitsche A; Senn BM; Verbeek JS; Odermatt B; Siegrist CA; Pinschewer DD. 2009. Impaired antibody response causes persistence of prototypic T cell-contained virus. PLoS Biol 7(4):e1000080. [PubMed: 19355789]  [MGI Ref ID J:150498]

Bergtold A; Desai DD; Gavhane A; Clynes R. 2005. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23(5):503-14. [PubMed: 16286018]  [MGI Ref ID J:113283]

Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. [PubMed: 16444258]  [MGI Ref ID J:112604]

Bode J; Dutow P; Sommer K; Janik K; Glage S; Tummler B; Munder A; Laudeley R; Sachse KW; Klos A. 2012. A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One 7(11):e50327. [PubMed: 23189195]  [MGI Ref ID J:194784]

Borkowska S; Suszynska M; Mierzejewska K; Ismail A; Budkowska M; Salata D; Dolegowska B; Kucia M; Ratajczak J; Ratajczak MZ. 2014. Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs). Leukemia 28(11):2148-54. [PubMed: 24667943]  [MGI Ref ID J:216036]

Borkowska S; Suszynska M; Wysoczynski M; Ratajczak MZ. 2013. Mobilization studies in C3-deficient mice unravel the involvement of a novel crosstalk between the coagulation and complement cascades in mobilization of hematopoietic stem/progenitor cells. Leukemia 27(9):1928-30. [PubMed: 23511127]  [MGI Ref ID J:200120]

Buono C; Come CE; Witztum JL; Maguire GF; Connelly PW; Carroll M; Lichtman AH. 2002. Influence of C3 deficiency on atherosclerosis. Circulation 105(25):3025-31. [PubMed: 12081998]  [MGI Ref ID J:103349]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Chen Y; Park YB; Patel E; Silverman GJ. 2009. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol 182(10):6031-43. [PubMed: 19414754]  [MGI Ref ID J:148245]

Chow WN; Lee YL; Wong PC; Chung MK; Lee KF; Yeung WS. 2009. Complement 3 deficiency impairs early pregnancy in mice. Mol Reprod Dev 76(7):647-55. [PubMed: 19205046]  [MGI Ref ID J:150898]

Clynes R; Maizes JS; Guinamard R; Ono M; Takai T; Ravetch JV. 1999. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189(1):179-85. [PubMed: 9874574]  [MGI Ref ID J:112378]

Coles B; Lewis R; Anning PB; Morton J; Baalasubramanian S; Morgan BP; O'Donnell VB. 2007. CD59 or C3 are not requred for angiotensin II-dependent hypertension or hypertrophy in mice. Immunology 121(4):518-25. [PubMed: 17433074]  [MGI Ref ID J:125538]

Cortes-Hernandez J; Fossati-Jimack L; Carugati A; Potter PK; Walport MJ; Cook HT; Botto M. 2002. Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms. Clin Exp Immunol 130(3):459-66. [PubMed: 12452836]  [MGI Ref ID J:115531]

Crow AR; Song S; Suppa SJ; Ma S; Reilly MP; Andre P; McKenzie SE; Lazarus AH. 2011. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood 117(3):971-4. [PubMed: 21045192]  [MGI Ref ID J:168394]

Cunnion KM; Benjamin DK Jr; Hester CG; Frank MM. 2004. Role of complement receptors 1 and 2 (CD35 and CD21), C3, C4, and C5 in survival by mice of Staphylococcus aureus bacteremia. J Lab Clin Med 143(6):358-65. [PubMed: 15192652]  [MGI Ref ID J:101948]

Donius LR; Handy JM; Weis JJ; Weis JH. 2013. Optimal germinal center B cell activation and T-dependent antibody responses require expression of the mouse complement receptor Cr1. J Immunol 191(1):434-47. [PubMed: 23733878]  [MGI Ref ID J:205353]

Ehrnthaller C; Huber-Lang M; Nilsson P; Bindl R; Redeker S; Recknagel S; Rapp A; Mollnes T; Amling M; Gebhard F; Ignatius A. 2013. Complement C3 and C5 deficiency affects fracture healing. PLoS One 8(11):e81341. [PubMed: 24260573]  [MGI Ref ID J:209669]

Einav S; Pozdnyakova OO; Ma M; Carroll MC. 2002. Complement C4 is protective for lupus disease independent of C3. J Immunol 168(3):1036-41. [PubMed: 11801636]  [MGI Ref ID J:127292]

Engelbert M; Gilmore MS. 2005. Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis. Invest Ophthalmol Vis Sci 46(7):2479-86. [PubMed: 15980239]  [MGI Ref ID J:136745]

Fang C; Miwa T; Shen H; Song WC. 2007. Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice. J Immunol 179(5):3178-86. [PubMed: 17709533]  [MGI Ref ID J:151828]

Fang C; Miwa T; Song WC. 2011. Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells. Blood 118(4):1008-14. [PubMed: 21652682]  [MGI Ref ID J:174858]

Fang C; Zhang X; Miwa T; Song WC. 2009. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood 114(5):1005-15. [PubMed: 19491392]  [MGI Ref ID J:151430]

Farrar CA; Zhou W; Lin T; Sacks SH. 2006. Local extravascular pool of C3 is a determinant of postischemic acute renal failure. FASEB J 20(2):217-26. [PubMed: 16449793]  [MGI Ref ID J:105786]

Fischer MB; Ma M; Goerg S; Zhou X; Xia J; Finco O; Han S; Kelsoe G; Howard RG; Rothstein TL; Kremmer E; Rosen FS; Carroll MC. 1996. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J Immunol 157(2):549-56. [PubMed: 8752901]  [MGI Ref ID J:64282]

Fischer MB; Prodeus AP; Nicholson-Weller A; Ma M; Murrow J; Reid RR; Warren HB; Lage AL; Moore FD Jr; Rosen FS; Carroll MC. 1997. Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement. J Immunol 159(2):976-82. [PubMed: 9218619]  [MGI Ref ID J:78654]

Fossati-Jimack L; Ling GS; Baudino L; Szajna M; Manivannan K; Zhao JC; Midgley R; Chai JG; Simpson E; Botto M; Scott D. 2015. Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology 144(1):149-57. [PubMed: 25039245]  [MGI Ref ID J:220131]

Frost JL; Le KX; Cynis H; Ekpo E; Kleinschmidt M; Palmour RM; Ervin FR; Snigdha S; Cotman CW; Saido TC; Vassar RJ; George-Hyslop PS; Ikezu T; Schilling S; Demuth HU; Lemere CA. 2013. Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models. Am J Pathol 183(2):369-81. [PubMed: 23747948]  [MGI Ref ID J:199082]

Fu H; Liu B; Frost JL; Hong S; Jin M; Ostaszewski B; Shankar GM; Costantino IM; Carroll MC; Mayadas TN; Lemere CA. 2012. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia. Glia 60(6):993-1003. [PubMed: 22438044]  [MGI Ref ID J:183868]

Gao X; Liu H; Ding G; Wang Z; Fu H; Ni Z; Ma J; Liu F; Fu Z. 2011. Complement C3 deficiency prevent against the onset of streptozotocin-induced autoimmune diabetes involving expansion of regulatory T cells. Clin Immunol 140(3):236-43. [PubMed: 21767994]  [MGI Ref ID J:177207]

Gao X; Liu H; He B; Fu Z. 2013. Resistance to Streptozotocin-Induced Autoimmune Diabetes in Absence of Complement C3: Myeloid-Derived Suppressor Cells Play a Role. PLoS One 8(6):e66334. [PubMed: 23824734]  [MGI Ref ID J:203459]

Gaspal FM; McConnell FM; Kim MY; Gray D; Kosco-Vilbois MH; Raykundalia CR; Botto M; Lane PJ. 2006. The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand. Eur J Immunol 36(7):1665-73. [PubMed: 16783845]  [MGI Ref ID J:115798]

Giacomin PR; Gordon DL; Botto M; Daha MR; Sanderson SD; Taylor SM; Dent LA. 2008. The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Mol Immunol 45(2):446-55. [PubMed: 17675237]  [MGI Ref ID J:125347]

Goins CL; Chappell CP; Shashidharamurthy R; Selvaraj P; Jacob J. 2010. Immune complex-mediated enhancement of secondary antibody responses. J Immunol 184(11):6293-8. [PubMed: 20439912]  [MGI Ref ID J:161221]

Guo Q; Li S; Liang Y; Zhang Y; Zhang J; Wen C; Lin S; Wang H; Su B. 2010. Effects of C3 deficiency on inflammation and regeneration following spinal cord injury in mice. Neurosci Lett 485(1):32-6. [PubMed: 20800648]  [MGI Ref ID J:166093]

Guttormsen HK; Stuart LM; Shi L; Carroll MC; Chen J; Kasper DL; Ezekowitz RA; Takahashi K. 2009. Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination. Clin Immunol 130(3):264-71. [PubMed: 18996748]  [MGI Ref ID J:145190]

Haas KM; Poe JC; Tedder TF. 2009. CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. J Immunol 183(6):3661-71. [PubMed: 19710450]  [MGI Ref ID J:152400]

Hall LR; Diaconu E; Pearlman E. 2001. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J Immunol 167(2):919-25. [PubMed: 11441099]  [MGI Ref ID J:120230]

Han R; Frett EM; Levy JR; Rader EP; Lueck JD; Bansal D; Moore SA; Ng R; Beltran-Valero de Bernabe D; Faulkner JA; Campbell KP. 2010. Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice. J Clin Invest 120(12):4366-74. [PubMed: 21060153]  [MGI Ref ID J:171870]

Harbers SO; Crocker A; Catalano G; D'Agati V; Jung S; Desai DD; Clynes R. 2007. Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest 117(5):1361-9. [PubMed: 17446931]  [MGI Ref ID J:122114]

Hasegawa M; Fujimoto M; Poe JC; Steeber DA; Tedder TF. 2001. CD19 can regulate B lymphocyte signal transduction independent of complement activation. J Immunol 167(6):3190-200. [PubMed: 11544305]  [MGI Ref ID J:118767]

He S; Atkinson C; Evans Z; Ellett JD; Southwood M; Elvington A; Chavin KD; Tomlinson S. 2009. A role for complement in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury. J Immunol 183(7):4764-72. [PubMed: 19752222]  [MGI Ref ID J:152771]

He S; Atkinson C; Qiao F; Cianflone K; Chen X; Tomlinson S. 2009. A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J Clin Invest 119(8):2304-16. [PubMed: 19620784]  [MGI Ref ID J:152533]

Hebert MJ; Takano T; Papayianni A; Rennke HG; Minto A; Salant DJ; Carroll MC; Brady HR. 1998. Acute nephrotoxic serum nephritis in complement knockout mice: relative roles of the classical and alternate pathways in neutrophil recruitment and proteinuria. Nephrol Dial Transplant 13(11):2799-803. [PubMed: 9829481]  [MGI Ref ID J:77011]

Hidalgo A; Chang J; Jang JE; Peired AJ; Chiang EY; Frenette PS. 2009. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med 15(4):384-91. [PubMed: 19305412]  [MGI Ref ID J:149370]

Hirahashi J; Mekala D; Van Ziffle J; Xiao L; Saffaripour S; Wagner DD; Shapiro SD; Lowell C; Mayadas TN. 2006. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 25(2):271-83. [PubMed: 16872848]  [MGI Ref ID J:113463]

Ho-Tin-Noe B; Carbo C; Demers M; Cifuni SM; Goerge T; Wagner DD. 2009. Innate immune cells induce hemorrhage in tumors during thrombocytopenia. Am J Pathol 175(4):1699-708. [PubMed: 19729481]  [MGI Ref ID J:153057]

Hod EA; Cadwell CM; Liepkalns JS; Zimring JC; Sokol SA; Schirmer DA; Jhang J; Spitalnik SL. 2008. Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions. Blood 112(3):891-4. [PubMed: 18483395]  [MGI Ref ID J:138442]

Hoffmeister KM; Felbinger TW; Falet H; Denis CV; Bergmeier W; Mayadas TN; von Andrian UH; Wagner DD; Stossel TP; Hartwig JH. 2003. The clearance mechanism of chilled blood platelets. Cell 112(1):87-97. [PubMed: 12526796]  [MGI Ref ID J:107707]

Hoh Kam J; Lenassi E; Malik TH; Pickering MC; Jeffery G. 2013. Complement component c3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. Am J Pathol 183(2):480-92. [PubMed: 23747511]  [MGI Ref ID J:198723]

Hong F; Hansen RD; Yan J; Allendorf DJ; Baran JT; Ostroff GR; Ross GD. 2003. Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Res 63(24):9023-31. [PubMed: 14695221]  [MGI Ref ID J:87069]

Hsieh CC; Chou HS; Yang HR; Lin F; Bhatt S; Qin J; Wang L; Fung JJ; Qian S; Lu L. 2013. The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells. Blood 121(10):1760-8. [PubMed: 23299310]  [MGI Ref ID J:194758]

Huang H; Ostroff GR; Lee CK; Agarwal S; Ram S; Rice PA; Specht CA; Levitz SM. 2012. Relative contributions of dectin-1 and complement to immune responses to particulate beta-glucans. J Immunol 189(1):312-7. [PubMed: 22649195]  [MGI Ref ID J:188946]

Imai M; Landen C; Ohta R; Cheung NK; Tomlinson S. 2005. Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer. Cancer Res 65(22):10562-8. [PubMed: 16288049]  [MGI Ref ID J:103401]

Ip WK; Takahashi K; Moore KJ; Stuart LM; Ezekowitz RA. 2008. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med 205(1):169-81. [PubMed: 18180310]  [MGI Ref ID J:131122]

Ito K; Furukawa J; Yamada K; Tran NL; Shinohara Y; Izui S. 2014. Lack of galactosylation enhances the pathogenic activity of IgG1 but Not IgG2a anti-erythrocyte autoantibodies. J Immunol 192(2):581-8. [PubMed: 24337750]  [MGI Ref ID J:207322]

Joller N; Weber SS; Muller AJ; Sporri R; Selchow P; Sander P; Hilbi H; Oxenius A. 2010. Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting. Proc Natl Acad Sci U S A 107(47):20441-6. [PubMed: 21048081]  [MGI Ref ID J:166599]

Kandasamy M; Ying PC; Ho AW; Sumatoh HR; Schlitzer A; Hughes TR; Kemeny DM; Morgan BP; Ginhoux F; Sivasankar B. 2013. Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog 9(1):e1003115. [PubMed: 23326231]  [MGI Ref ID J:195879]

Kang YS; Do Y; Lee HK; Park SH; Cheong C; Lynch RM; Loeffler JM; Steinman RM; Park CG. 2006. A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Cell 125(1):47-58. [PubMed: 16615889]  [MGI Ref ID J:115872]

Kelly MM; McNagny K; Williams DL; van Rooijen N; Maxwell L; Gwozd C; Mody CH; Kubes P. 2008. The lung responds to zymosan in a unique manner independent of toll-like receptors, complement, and dectin-1. Am J Respir Cell Mol Biol 38(2):227-38. [PubMed: 17717323]  [MGI Ref ID J:146394]

Kenyon KD; Cole C; Crawford F; Kappler JW; Thurman JM; Bratton DL; Boackle SA; Henson PM. 2011. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol 187(5):2101-11. [PubMed: 21813769]  [MGI Ref ID J:179122]

Kerepesi LA; Hess JA; Nolan TJ; Schad GA; Abraham D. 2006. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol 176(7):4315-22. [PubMed: 16547268]  [MGI Ref ID J:129872]

Kerr AR; Paterson GK; Riboldi-Tunnicliffe A; Mitchell TJ. 2005. Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. Infect Immun 73(7):4245-52. [PubMed: 15972516]  [MGI Ref ID J:99281]

Khan MA; Maasch C; Vater A; Klussmann S; Morser J; Leung LL; Atkinson C; Tomlinson S; Heeger PS; Nicolls MR. 2013. Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proc Natl Acad Sci U S A 110(15):6061-6. [PubMed: 23530212]  [MGI Ref ID J:196191]

Kim SH; Visser A; Cruijsen C; van der Velden AW; Boes M. 2008. Recruitment of Rab27a to phagosomes controls microbial antigen cross-presentation by dendritic cells. Infect Immun 76(11):5373-80. [PubMed: 18779337]  [MGI Ref ID J:142540]

Koch CA; Jordan CE; Platt JL. 2006. Complement-dependent control of teratoma formation by embryonic stem cells. J Immunol 177(7):4803-9. [PubMed: 16982921]  [MGI Ref ID J:139307]

Kopf M; Abel B; Gallimore A; Carroll M; Bachmann MF. 2002. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection. Nat Med 8(4):373-8. [PubMed: 11927943]  [MGI Ref ID J:126202]

Kopf M; Herren S; Wiles MV; Pepys MB; Kosco-Vilbois MH. 1998. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J Exp Med 188(10):1895-906. [PubMed: 9815267]  [MGI Ref ID J:79296]

Kuehn MH; Kim CY; Jiang B; Dumitrescu AV; Kwon YH. 2008. Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Exp Eye Res 87(2):89-95. [PubMed: 18572163]  [MGI Ref ID J:138248]

Kumar V; Ali SR; Konrad S; Zwirner J; Verbeek JS; Schmidt RE; Gessner JE. 2006. Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice. J Clin Invest 116(2):512-20. [PubMed: 16453025]  [MGI Ref ID J:105421]

Kwan WH; Hashimoto D; Paz-Artal E; Ostrow K; Greter M; Raedler H; Medof ME; Merad M; Heeger PS. 2012. Antigen-presenting cell-derived complement modulates graft-versus-host disease. J Clin Invest 122(6):2234-8. [PubMed: 22585573]  [MGI Ref ID J:190492]

Lalli PN; Strainic MG; Yang M; Lin F; Medof ME; Heeger PS. 2008. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood 112(5):1759-66. [PubMed: 18567839]  [MGI Ref ID J:138718]

Leung VW; Yun S; Botto M; Mason JC; Malik TH; Song W; Paixao-Cavalcante D; Pickering MC; Boyle JJ; Haskard DO. 2009. Decay-accelerating factor suppresses complement C3 activation and retards atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 175(4):1757-67. [PubMed: 19729477]  [MGI Ref ID J:153060]

Li K; Anderson KJ; Peng Q; Noble A; Lu B; Kelly AP; Wang N; Sacks SH; Zhou W. 2008. Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation. Blood 112(13):5084-94. [PubMed: 18812470]  [MGI Ref ID J:144259]

Li Y; Lin F. 2012. Mesenchymal stem cells are injured by complement after their contact with serum. Blood 120(17):3436-43. [PubMed: 22966167]  [MGI Ref ID J:191420]

Liang Y; Li S; Guo Q; Zhang Y; Wen C; Zou Q; Su B. 2007. Complement 3-deficient mice are not protected against MPTP-induced dopaminergic neurotoxicity. Brain Res 1178:132-40. [PubMed: 17900537]  [MGI Ref ID J:127243]

Lin M; Yin N; Murphy B; Medof ME; Segerer S; Heeger PS; Schroppel B. 2010. Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes 59(9):2247-52. [PubMed: 20584999]  [MGI Ref ID J:169632]

Link A; Zabel F; Schnetzler Y; Titz A; Brombacher F; Bachmann MF. 2012. Innate immunity mediates follicular transport of particulate but not soluble protein antigen. J Immunol 188(8):3724-33. [PubMed: 22427639]  [MGI Ref ID J:184059]

Liu J; Miwa T; Hilliard B; Chen Y; Lambris JD; Wells AD; Song WC. 2005. The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med 201(4):567-77. [PubMed: 15710649]  [MGI Ref ID J:96689]

Lobsiger CS; Boillee S; Pozniak C; Khan AM; McAlonis-Downes M; Lewcock JW; Cleveland DW. 2013. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci U S A 110(46):E4385-92. [PubMed: 24170856]  [MGI Ref ID J:202888]

Longhi MP; Sivasankar B; Omidvar N; Morgan BP; Gallimore A. 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol 175(11):7098-102. [PubMed: 16301611]  [MGI Ref ID J:122201]

Lu F; Chauhan AK; Fernandes SM; Walsh MT; Wagner DD; Davis AE 3rd. 2008. The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Am J Physiol Gastrointest Liver Physiol 295(5):G1042-9. [PubMed: 18787060]  [MGI Ref ID J:142529]

Lund FE; Schuer K; Hollifield M; Randall TD; Garvy BA. 2003. Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P carinii-specific antibody. J Immunol 171(3):1423-30. [PubMed: 12874234]  [MGI Ref ID J:120666]

Maehara N; Arai S; Mori M; Iwamura Y; Kurokawa J; Kai T; Kusunoki S; Taniguchi K; Ikeda K; Ohara O; Yamamura K; Miyazaki T. 2014. Circulating AIM prevents hepatocellular carcinoma through complement activation. Cell Rep 9(1):61-74. [PubMed: 25284781]  [MGI Ref ID J:218542]

Maier M; Peng Y; Jiang L; Seabrook TJ; Carroll MC; Lemere CA. 2008. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci 28(25):6333-41. [PubMed: 18562603]  [MGI Ref ID J:135902]

Miwa T; Sato S; Gullipalli D; Nangaku M; Song WC. 2013. Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice. J Immunol 190(7):3552-9. [PubMed: 23427256]  [MGI Ref ID J:194520]

Miwa T; Zhou L; Kimura Y; Kim D; Bhandoola A; Song WC. 2009. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113(12):2684-94. [PubMed: 19136662]  [MGI Ref ID J:146538]

Moalli F; Doni A; Deban L; Zelante T; Zagarella S; Bottazzi B; Romani L; Mantovani A; Garlanda C. 2010. Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood 116(24):5170-80. [PubMed: 20829368]  [MGI Ref ID J:167412]

Moalli F; Paroni M; Veliz Rodriguez T; Riva F; Polentarutti N; Bottazzi B; Valentino S; Mantero S; Nebuloni M; Mantovani A; Bragonzi A; Garlanda C. 2011. The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol 186(9):5425-34. [PubMed: 21441447]  [MGI Ref ID J:172858]

Mocco J; Mack WJ; Ducruet AF; Sosunov SA; Sughrue ME; Hassid BG; Nair MN; Laufer I; Komotar RJ; Claire M; Holland H; Pinsky DJ; Connolly ES Jr. 2006. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res 99(2):209-17. [PubMed: 16778128]  [MGI Ref ID J:123658]

Mold C; Rodic-Polic B; Du Clos TW. 2002. Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 168(12):6375-81. [PubMed: 12055255]  [MGI Ref ID J:123793]

Moll T; Nitschke L; Carroll M; Ravetch JV; Izui S. 2004. A critical role for Fc gamma RIIB in the induction of rheumatoid factors. J Immunol 173(7):4724-8. [PubMed: 15383609]  [MGI Ref ID J:93718]

Moller-Kristensen M; Hamblin MR; Thiel S; Jensenius JC; Takahashi K. 2007. Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice. J Invest Dermatol 127(6):1524-31. [PubMed: 17363917]  [MGI Ref ID J:121549]

Morrison TE; Fraser RJ; Smith PN; Mahalingam S; Heise MT. 2007. Complement contributes to inflammatory tissue destruction in a mouse model of ross river virus-induced disease. J Virol 81(10):5132-43. [PubMed: 17314163]  [MGI Ref ID J:121097]

Morrison TE; Simmons JD; Heise MT. 2008. Complement receptor 3 promotes severe ross river virus-induced disease. J Virol 82(22):11263-72. [PubMed: 18787004]  [MGI Ref ID J:153394]

Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. [PubMed: 18281503]  [MGI Ref ID J:135580]

Mullaly SC; Kubes P. 2007. Mast cell-expressed complement receptor, not TLR2, is the main detector of zymosan in peritonitis. Eur J Immunol 37(1):224-34. [PubMed: 17154261]  [MGI Ref ID J:117071]

Munkonda MN; Lapointe M; Miegueu P; Roy C; Gauvreau D; Richard D; Cianflone K. 2012. Recombinant acylation stimulating protein administration to C3-/- mice increases insulin resistance via adipocyte inflammatory mechanisms. PLoS One 7(10):e46883. [PubMed: 23056509]  [MGI Ref ID J:192101]

Naito AT; Sumida T; Nomura S; Liu ML; Higo T; Nakagawa A; Okada K; Sakai T; Hashimoto A; Hara Y; Shimizu I; Zhu W; Toko H; Katada A; Akazawa H; Oka T; Lee JK; Minamino T; Nagai T; Walsh K; Kikuchi A; Matsumoto M; Botto M; Shiojima I; Komuro I. 2012. Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes. Cell 149(6):1298-313. [PubMed: 22682250]  [MGI Ref ID J:186158]

Nguyen CQ; Kim H; Cornelius JG; Peck AB. 2007. Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3. J Immunol 179(4):2318-29. [PubMed: 17675493]  [MGI Ref ID J:151221]

Nimmerjahn F; Anthony RM; Ravetch JV. 2007. Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. Proc Natl Acad Sci U S A 104(20):8433-7. [PubMed: 17485663]  [MGI Ref ID J:121840]

Nimmerjahn F; Ravetch JV. 2005. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 310(5753):1510-2. [PubMed: 16322460]  [MGI Ref ID J:103229]

Nishiguchi KM; Yasuma TR; Tomida D; Nakamura M; Ishikawa K; Kikuchi M; Ohmi Y; Niwa T; Hamajima N; Furukawa K; Terasaki H. 2012. C9-R95X polymorphism in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 53(1):508-12. [PubMed: 22190594]  [MGI Ref ID J:191511]

Nunez-Cruz S; Gimotty PA; Guerra MW; Connolly DC; Wu YQ; DeAngelis RA; Lambris JD; Coukos G; Scholler N. 2012. Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization. Neoplasia 14(11):994-1004. [PubMed: 23226093]  [MGI Ref ID J:194414]

O'Brien KB; Morrison TE; Dundore DY; Heise MT; Schultz-Cherry S. 2011. A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS One 6(3):e17377. [PubMed: 21408070]  [MGI Ref ID J:171714]

O'Connell AE; Hess JA; Santiago GA; Nolan TJ; Lok JB; Lee JJ; Abraham D. 2011. Major Basic Protein from Eosinophils and Myeloperoxidase from Neutrophils Are Required for Protective Immunity to Strongyloides stercoralis in Mice. Infect Immun 79(7):2770-8. [PubMed: 21482685]  [MGI Ref ID J:173497]

Ochsenbein AF; Pinschewer DD; Odermatt B; Carroll MC; Hengartner H; Zinkernagel RM. 1999. Protective T cell-independent antiviral antibody responses are dependent on complement. J Exp Med 190(8):1165-74. [PubMed: 10523614]  [MGI Ref ID J:115126]

Ohmi Y; Tajima O; Ohkawa Y; Mori A; Sugiura Y; Furukawa K; Furukawa K. 2009. Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci U S A 106(52):22405-10. [PubMed: 20018737]  [MGI Ref ID J:156459]

Otten MA; Groeneveld TW; Flierman R; Rastaldi MP; Trouw LA; Faber-Krol MC; Visser A; Essers MC; Claassens J; Verbeek JS; van Kooten C; Roos A; Daha MR. 2009. Both complement and IgG fc receptors are required for development of attenuated antiglomerular basement membrane nephritis in mice. J Immunol 183(6):3980-8. [PubMed: 19710463]  [MGI Ref ID J:152300]

Peng Q; Li K; Anderson K; Farrar CA; Lu B; Smith RA; Sacks SH; Zhou W. 2008. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood 111(4):2452-61. [PubMed: 18056835]  [MGI Ref ID J:131316]

Peng Q; Li K; Patel H; Sacks SH; Zhou W. 2006. Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol 176(6):3330-41. [PubMed: 16517700]  [MGI Ref ID J:129540]

Pozdnyakova O; Guttormsen HK; Lalani FN; Carroll MC; Kasper DL. 2003. Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice. J Immunol 170(1):84-90. [PubMed: 12496386]  [MGI Ref ID J:127041]

Pritchard MT; McMullen MR; Stavitsky AB; Cohen JI; Lin F; Medof ME; Nagy LE. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132(3):1117-26. [PubMed: 17383432]  [MGI Ref ID J:128218]

Prodeus AP; Zhou X; Maurer M; Galli SJ; Carroll MC. 1997. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature 390(6656):172-5. [PubMed: 9367154]  [MGI Ref ID J:44240]

Qiao F; Atkinson C; Song H; Pannu R; Singh I; Tomlinson S. 2006. Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma. Am J Pathol 169(3):1039-47. [PubMed: 16936276]  [MGI Ref ID J:112353]

Qin D; Wu J; Carroll MC; Burton GF; Szakal AK; Tew JG. 1998. Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses. J Immunol 161(9):4549-54. [PubMed: 9794381]  [MGI Ref ID J:112151]

Qin X; Dobarro M; Bedford SJ; Ferris S; Miranda PV; Song W; Bronson RT; Visconti PE; Halperin JA. 2005. Further characterization of reproductive abnormalities in mCd59b knockout mice: a potential new function of mCd59 in male reproduction. J Immunol 175(10):6294-302. [PubMed: 16272280]  [MGI Ref ID J:108100]

Qin X; Hu W; Song W; Grubissich L; Hu X; Wu G; Ferris S; Dobarro M; Halperin JA. 2009. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol 84(2):65-70. [PubMed: 19051264]  [MGI Ref ID J:170754]

Qing X; Koo GC; Salmon JE. 2012. Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-beta1 in Gr-1+ myeloid cells. Eur J Immunol 42(7):1723-34. [PubMed: 22535677]  [MGI Ref ID J:187776]

Quigg RJ; Lim A; Haas M; Alexander JJ; He C; Carroll MC. 1998. Immune complex glomerulonephritis in C4- and C3-deficient mice. Kidney Int 53(2):320-30. [PubMed: 9461092]  [MGI Ref ID J:47055]

Ratajczak J; Reca R; Kucia M; Majka M; Allendorf DJ; Baran JT; Janowska-Wieczorek A; Wetsel RA; Ross GD; Ratajczak MZ. 2004. Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow. Blood 103(6):2071-8. [PubMed: 14604969]  [MGI Ref ID J:88568]

Richter K; Oxenius A. 2013. Non-neutralizing antibodies protect from chronic LCMV infection independently of activating FcgammaR or complement. Eur J Immunol 43(9):2349-60. [PubMed: 23749374]  [MGI Ref ID J:201331]

Rodriguez W; Mold C; Kataranovski M; Hutt JA; Marnell LL; Verbeek JS; Du Clos TW. 2007. C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. J Immunol 178(1):530-8. [PubMed: 17182593]  [MGI Ref ID J:141920]

Rozanov DV; Savinov AY; Golubkov VS; Tomlinson S; Strongin AY. 2006. Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. Cancer Res 66(12):6258-63. [PubMed: 16778201]  [MGI Ref ID J:110103]

Rupprecht TA; Angele B; Klein M; Heesemann J; Pfister HW; Botto M; Koedel U. 2007. Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. J Immunol 178(3):1861-9. [PubMed: 17237437]  [MGI Ref ID J:143634]

Seregin SS; Aldhamen YA; Appledorn DM; Hartman ZC; Schuldt NJ; Scott J; Godbehere S; Jiang H; Frank MM; Amalfitano A. 2010. Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. Blood 116(10):1669-77. [PubMed: 20511542]  [MGI Ref ID J:164531]

Sheerin NS; Risley P; Abe K; Tang Z; Wong W; Lin T; Sacks SH. 2008. Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury. FASEB J 22(4):1065-72. [PubMed: 18039928]  [MGI Ref ID J:135262]

Sheerin NS; Springall T; Carroll M; Sacks SH. 1999. Altered distribution of intraglomerular immune complexes in C3-deficient mice. Immunology 97(3):393-9. [PubMed: 10447759]  [MGI Ref ID J:56335]

Sheerin NS; Springall T; Carroll MC; Hartley B; Sacks SH. 1997. Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice. Clin Exp Immunol 110(3):403-9. [PubMed: 9409643]  [MGI Ref ID J:44715]

Sood R; Sholl L; Isermann B; Zogg M; Coughlin SR; Weiler H. 2008. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood 112(3):585-91. [PubMed: 18490515]  [MGI Ref ID J:138440]

Sponarova J; Nuvolone M; Whicher C; Frei N; Kana V; Schwarz P; Westermark GT; Aguzzi A. 2013. Efficient amyloid a clearance in the absence of immunoglobulins and complement factors. Am J Pathol 182(4):1297-307. [PubMed: 23454183]  [MGI Ref ID J:195307]

Springall T; Sheerin NS; Abe K; Holers VM; Wan H; Sacks SH. 2001. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Nat Med 7(7):801-6. [PubMed: 11433344]  [MGI Ref ID J:70251]

Stephan AH; Madison DV; Mateos JM; Fraser DA; Lovelett EA; Coutellier L; Kim L; Tsai HH; Huang EJ; Rowitch DH; Berns DS; Tenner AJ; Shamloo M; Barres BA. 2013. A Dramatic Increase of C1q Protein in the CNS during Normal Aging. J Neurosci 33(33):13460-13474. [PubMed: 23946404]  [MGI Ref ID J:200899]

Stevens B; Allen NJ; Vazquez LE; Howell GR; Christopherson KS; Nouri N; Micheva KD; Mehalow AK; Huberman AD; Stafford B; Sher A; Litke AM; Lambris JD; Smith SJ; John SW; Barres BA. 2007. The classical complement cascade mediates CNS synapse elimination. Cell 131(6):1164-78. [PubMed: 18083105]  [MGI Ref ID J:137589]

Stokol T; O'Donnell P; Xiao L; Knight S; Stavrakis G; Botto M; von Andrian UH; Mayadas TN. 2004. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med 200(7):835-46. [PubMed: 15466618]  [MGI Ref ID J:93949]

Stowell SR; Liepkalns JS; Hendrickson JE; Girard-Pierce KR; Smith NH; Arthur CM; Zimring JC. 2013. Antigen modulation confers protection to red blood cells from antibody through Fcgamma receptor ligation. J Immunol 191(10):5013-25. [PubMed: 24108700]  [MGI Ref ID J:206332]

Strainic MG; Liu J; Huang D; An F; Lalli PN; Muqim N; Shapiro VS; Dubyak GR; Heeger PS; Medof ME. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28(3):425-35. [PubMed: 18328742]  [MGI Ref ID J:132942]

Strainic MG; Shevach EM; An F; Lin F; Medof ME. 2012. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. Nat Immunol 14(2):162-71. [PubMed: 23263555]  [MGI Ref ID J:192613]

Straub T; Schweier O; Bruns M; Nimmerjahn F; Waisman A; Pircher H. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgammaR. Eur J Immunol 43(9):2338-48. [PubMed: 23749409]  [MGI Ref ID J:201330]

Sun K; Metzger DW. 2008. Inhibition of pulmonary antibacterial defense by interferon-gamma during recovery from influenza infection. Nat Med 14(5):558-64. [PubMed: 18438414]  [MGI Ref ID J:136669]

Sun S; Guo Y; Zhao G; Zhou X; Li J; Hu J; Yu H; Chen Y; Song H; Qiao F; Xu G; Yang F; Wu Y; Tomlinson S; Duan Z; Zhou Y. 2011. Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure. PLoS One 6(11):e26838. [PubMed: 22069473]  [MGI Ref ID J:181002]

Sylvestre D; Clynes R; Ma M; Warren H; Carroll MC; Ravetch JV. 1996. Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. J Exp Med 184(6):2385-92. [PubMed: 8976192]  [MGI Ref ID J:78296]

Takahashi K; Shi L; Gowda LD; Ezekowitz RA. 2005. Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection. Infect Immun 73(12):8188-93. [PubMed: 16299314]  [MGI Ref ID J:104305]

Tang T; Rosenkranz A; Assmann KJM; Goodman MJ; Gutierrez-Ramos JC ; Carroll MC ; Cotran RS ; Mayadas TN. 1997. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med 186(11):1853-63. [PubMed: 9382884]  [MGI Ref ID J:44403]

Taylor PR; Carugati A; Fadok VA; Cook HT; Andrews M; Carroll MC; Savill JS; Henson PM; Botto M; Walport MJ. 2000. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 192(3):359-66. [PubMed: 10934224]  [MGI Ref ID J:63875]

Trcka J; Moroi Y; Clynes RA; Goldberg SM; Bergtold A; Perales MA; Ma M; Ferrone CR; Carroll MC; Ravetch JV; Houghton AN. 2002. Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo. Immunity 16(6):861-8. [PubMed: 12121667]  [MGI Ref ID J:113538]

Trendelenburg M; Fossati-Jimack L; Cortes-Hernandez J; Turnberg D; Lewis M; Izui S; Cook HT; Botto M. 2005. The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol 175(10):6909-14. [PubMed: 16272350]  [MGI Ref ID J:119691]

Tsoni SV; Kerrigan AM; Marakalala MJ; Srinivasan N; Duffield M; Taylor PR; Botto M; Steele C; Brown GD. 2009. Complement C3 plays an essential role in the control of opportunistic fungal infections. Infect Immun 77(9):3679-85. [PubMed: 19581397]  [MGI Ref ID J:152233]

Tu Z; Bu H; Dennis JE; Lin F. 2010. Efficient osteoclast differentiation requires local complement activation. Blood 116(22):4456-63. [PubMed: 20709903]  [MGI Ref ID J:166640]

Turnberg D; Lewis M; Moss J; Xu Y; Botto M; Cook HT. 2006. Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol 177(6):4094-102. [PubMed: 16951374]  [MGI Ref ID J:138043]

Tuzun E; Scott BG; Goluszko E; Higgs S; Christadoss P. 2003. Genetic evidence for involvement of classical complement pathway in induction of experimental autoimmune myasthenia gravis. J Immunol 171(7):3847-54. [PubMed: 14500686]  [MGI Ref ID J:85645]

Twohig J; Kulik L; Haluszczak C; Reuter J; Rossbach A; Bull M; Holers VM; Marchbank KJ. 2007. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Mol Immunol 44(13):3434-44. [PubMed: 17379312]  [MGI Ref ID J:123562]

Veninga H; de Groot DM; McCloskey N; Owens BM; Dessing MC; Verbeek JS; Nourshargh S; van Eenennaam H; Boots AM; Hamann J. 2011. CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. J Leukoc Biol 89(3):413-21. [PubMed: 21169517]  [MGI Ref ID J:170387]

Verschoor A; Brockman MA; Gadjeva M; Knipe DM; Carroll MC. 2003. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. J Immunol 171(10):5363-71. [PubMed: 14607939]  [MGI Ref ID J:119310]

Verschoor A; Neuenhahn M; Navarini AA; Graef P; Plaumann A; Seidlmeier A; Nieswandt B; Massberg S; Zinkernagel RM; Hengartner H; Busch DH. 2011. A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha+ dendritic cells depends on glycoprotein GPIb and complement C3. Nat Immunol 12(12):1194-201. [PubMed: 22037602]  [MGI Ref ID J:179014]

Vieyra M; Leisman S; Raedler H; Kwan WH; Yang M; Strainic MG; Medof ME; Heeger PS. 2011. Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am J Pathol 179(2):766-74. [PubMed: 21704012]  [MGI Ref ID J:174402]

Welch TR; Blystone LW. 2005. C3 is central to the interstitial component of experimental immune complex glomerulonephritis. Clin Immunol 115(1):80-4. [PubMed: 15870025]  [MGI Ref ID J:105037]

Wessels MR; Butko P; Ma M; Warren HB; Lage AL; Carroll MC. 1995. Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity. Proc Natl Acad Sci U S A 92(25):11490-4. [PubMed: 8524789]  [MGI Ref ID J:30152]

Williams JP; Pechet TT; Weiser MR; Reid R; Kobzik L; Moore FD Jr; Carroll MC; Hechtman HB. 1999. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 86(3):938-42. [PubMed: 10066708]  [MGI Ref ID J:78613]

Woodman ME; Cooley AE; Avdiushko R; Bowman A; Botto M; Wooten RM; van Rooijen N; Cohen DA; Stevenson B. 2009. Roles for phagocytic cells and complement in controlling relapsing fever infection. J Leukoc Biol 86(3):727-36. [PubMed: 19458267]  [MGI Ref ID J:152584]

Woodruff TM; Lee JD; Noakes PG. 2014. Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proc Natl Acad Sci U S A 111(1):E3-4. [PubMed: 24381160]  [MGI Ref ID J:206365]

Woods KM; Pope MR; Hoffman SM; Fleming SD. 2011. CR2+ marginal zone B cell production of pathogenic natural antibodies is C3 independent. J Immunol 186(3):1755-62. [PubMed: 21187447]  [MGI Ref ID J:168910]

Wysoczynski M; Kucia M; Ratajczak J; Ratajczak MZ. 2007. Cleavage fragments of the third complement component (C3) enhance stromal derived factor-1 (SDF-1)-mediated platelet production during reactive postbleeding thrombocytosis. Leukemia 21(5):973-82. [PubMed: 17330096]  [MGI Ref ID J:121386]

Wysoczynski M; Solanki M; Borkowska S; van Hoose P; Brittian KR; Prabhu SD; Ratajczak MZ; Rokosh G. 2014. Complement component 3 is necessary to preserve myocardium and myocardial function in chronic myocardial infarction. Stem Cells 32(9):2502-15. [PubMed: 24806427]  [MGI Ref ID J:216779]

Yan J; Vetvicka V; Xia Y; Coxon A; Carroll MC; Mayadas TN; Ross GD. 1999. Beta-glucan, a 'specific' biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J Immunol 163(6):3045-52. [PubMed: 10477568]  [MGI Ref ID J:57602]

Yu M; Zou W; Peachey NS; McIntyre TM; Liu J. 2012. A novel role of complement in retinal degeneration. Invest Ophthalmol Vis Sci 53(12):7684-92. [PubMed: 23074214]  [MGI Ref ID J:214214]

Yuste J; Ali S; Sriskandan S; Hyams C; Botto M; Brown JS. 2006. Roles of the alternative complement pathway and C1q during innate immunity to Streptococcus pyogenes. J Immunol 176(10):6112-20. [PubMed: 16670320]  [MGI Ref ID J:131701]

Yuste J; Botto M; Paton JC; Holden DW; Brown JS. 2005. Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia. J Immunol 175(3):1813-9. [PubMed: 16034123]  [MGI Ref ID J:107276]

Zabel MD; Heikenwalder M; Prinz M; Arrighi I; Schwarz P; Kranich J; von Teichman A; Haas KM; Zeller N; Tedder TF; Weis JH; Aguzzi A. 2007. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. J Immunol 179(9):6144-52. [PubMed: 17947689]  [MGI Ref ID J:152995]

Zachrau B; Finke D; Kropf K; Gosink HJ; Kirchner H; Goerg S. 2004. Antigen localization within the splenic marginal zone restores humoral immune response and IgG class switch in complement C4-deficient mice. Int Immunol 16(12):1685-90. [PubMed: 15477230]  [MGI Ref ID J:94043]

Zelko I; Kobayashi R; Honkakoski P; Negishi M. 1998. Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys 352(1):31-6. [PubMed: 9521809]  [MGI Ref ID J:46795]

Zhang G; Bogdanova N; Gao T; Song JJ; Cragg MS; Glennie MJ; Sheikh KA. 2014. Fcgamma receptor-mediated inflammation inhibits axon regeneration. PLoS One 9(2):e88703. [PubMed: 24523933]  [MGI Ref ID J:212944]

Zhang J; Hu W; Xing W; You T; Xu J; Qin X; Peng Z. 2011. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol 179(6):2876-84. [PubMed: 22019898]  [MGI Ref ID J:180268]

Zhang X; Kimura Y; Fang C; Zhou L; Sfyroera G; Lambris JD; Wetsel RA; Miwa T; Song WC. 2007. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110(1):228-36. [PubMed: 17363730]  [MGI Ref ID J:145413]

Zhao L; Ma W; Fariss RN; Wong WT. 2011. Minocycline attenuates photoreceptor degeneration in a mouse model of subretinal hemorrhage microglial: inhibition as a potential therapeutic strategy. Am J Pathol 179(3):1265-77. [PubMed: 21763674]  [MGI Ref ID J:179950]

Zhou W; Farrar CA; Abe K; Pratt JR; Marsh JE; Wang Y; Stahl GL; Sacks SH. 2000. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 105(10):1363-71. [PubMed: 10811844]  [MGI Ref ID J:120567]

Zhou W; Patel H; Li K; Peng Q; Villiers MB; Sacks SH. 2006. Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells. Blood 107(6):2461-9. [PubMed: 16304047]  [MGI Ref ID J:129369]

Zhou X; Fukuda N; Matsuda H; Endo M; Wang X; Saito K; Ueno T; Matsumoto T; Matsumoto K; Soma M; Kobayashi N; Nishiyama A. 2013. Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice. Am J Physiol Renal Physiol 305(7):F957-67. [PubMed: 23926185]  [MGI Ref ID J:202043]

Zietara N; Lyszkiewicz M; Puchalka J; Pei G; Gutierrez MG; Lienenklaus S; Hobeika E; Reth M; Martins dos Santos VA; Krueger A; Weiss S. 2013. Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A 110(6):2282-7. [PubMed: 23345431]  [MGI Ref ID J:194334]

de Jong JM; Schuurhuis DH; Ioan-Facsinay A; van der Voort EI; Huizinga TW; Ossendorp F; Toes RE; Verbeek JS. 2006. Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8(+) T cells in vivo. Mol Immunol 43(13):2045-50. [PubMed: 16513171]  [MGI Ref ID J:108110]

de Jorge EG; Macor P; Paixao-Cavalcante D; Rose KL; Tedesco F; Cook HT; Botto M; Pickering MC. 2011. The development of atypical hemolytic uremic syndrome depends on complement C5. J Am Soc Nephrol 22(1):137-45. [PubMed: 21148255]  [MGI Ref ID J:185883]

de Visser KE; Korets LV; Coussens LM. 2004. Early neoplastic progression is complement independent. Neoplasia 6(6):768-76. [PubMed: 15720803]  [MGI Ref ID J:97876]

van Montfoort N; de Jong JM; Schuurhuis DH; van der Voort EI; Camps MG; Huizinga TW; van Kooten C; Daha MR; Verbeek JS; Ossendorp F; Toes RE. 2007. A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes. J Immunol 178(12):7581-6. [PubMed: 17548593]  [MGI Ref ID J:148593]

Man2a1tm1Jxm related

Akama TO; Nakagawa H; Wong NK; Sutton-Smith M; Dell A; Morris HR; Nakayama J; Nishimura S; Pai A; Moremen KW; Marth JD; Fukuda MN. 2006. Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice. Proc Natl Acad Sci U S A 103(24):8983-8. [PubMed: 16754854]  [MGI Ref ID J:111055]

Chui D; Oh-Eda M; Liao YF; Panneerselvam K; Lal A; Marek KW ; Freeze HH ; Moremen KW ; Fukuda MN ; Marth JD. 1997. Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis. Cell 90(1):157-67. [PubMed: 9230311]  [MGI Ref ID J:41621]

Chui D; Sellakumar G; Green R; Sutton-Smith M; McQuistan T; Marek K; Morris H; Dell A; Marth J. 2001. Genetic remodeling of protein glycosylation in vivo induces autoimmune disease. Proc Natl Acad Sci U S A 98(3):1142-7. [PubMed: 11158608]  [MGI Ref ID J:74579]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintained as a live colony, double heterozygous or double homozygous mice may be bred.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.