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Use Restrictions Apply, see Terms of Use
Common Names: ROSA26::FLPe knock in;    
This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines.


Strain Information

Former Names B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/JRainJ    (Changed: 02-APR-09 )
Type Congenic; Targeted Mutation;
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Mating SystemHomozygote x Homozygote         (Female x Male)   26-APR-10
Specieslaboratory mouse
GenerationN10+N1F5 (09-JUN-15)
Generation Definitions
Donating Investigator Elaine W Raines and Carole L Wilson,   Univ. Washington School of Medicine

Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wild type FLP at 37C and 40C, respectively. The Gt(ROSA)26Sor promoter drives expression from preimplantation onward and extensive target gene recombination can be achieved in most tissue types, including cells of the developing germ line. When bred with mice containing a frt-flanked sequence of interest, FLP-mediated recombination will result in deletion of the frt-flanked sequence(s) in the offspring. This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Homozygous males from The Jackson Laboratory strain 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J (Stock No. 003946) were purchased by Elaine W. Raines and Carole L. Wilson (University of Washington School of Medicine). Mutant males were backcrossed to C57BL/6J inbred females (see Stock No. 000664) for ten generations and then made homozygous prior to arrival at The Jackson Laboratory (as Stock No. 009086). The Y chromosome may not have been fixed to the genetic background during the backcross.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Gt(ROSA)26Sortm1(FLP1)Dym allele
003946   129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J
016226   B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J
View Strains carrying   Gt(ROSA)26Sortm1(FLP1)Dym     (2 strains)

View Strains carrying other alleles of FLP     (12 strains)

Strains carrying other alleles of Gt(ROSA)26Sor
002292   129-Gt(ROSA)26Sor/J
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
013205   129S-Gt(ROSA)26Sortm1(NOTCH3)Sat/Mmjax
003310   129S-Gt(ROSA)26Sortm1Sor/J
013207   129S-Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/Mmjax
009043   129S-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007844   129S4/SvJae-Gt(ROSA)26Sortm2(FLP*)Sor/J
007689   129S4/SvJaeSor-Gt(ROSA)26Sortm4(attB/attP)Sor/J
017626   B6(Cg)-Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/J
026283   B6(Cg)-Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/J
010633   B6(Cg)-Gt(ROSA)26Sortm1(CAG-taulacZ)Bene/J
024540   B6(Cg)-Gt(ROSA)26Sortm1(Sstr3/GFP)Bky/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
007708   B6.129-Gt(ROSA)26Sortm1(HD*103Q)Xwy/J
024512   B6.129-Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011008   B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J
017492   B6.129P2-Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
009669   B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J
008513   B6.129P2-Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/J
013586   B6.129P2-Gt(ROSA)26Sortm1Nik/J
013587   B6.129P2-Gt(ROSA)26Sortm3Nik/J
022367   B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
012930   B6.129S4-Gt(ROSA)26Sortm2(FLP*)Sor/J
009044   B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J
007743   B6.129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
009673   B6.129S6(C)-Gt(ROSA)26Sortm3(HIF1A*)Kael/J
022626   B6.129S6(SJL)-Gt(ROSA)26Sortm2.1(mix1b-mCherry)Mgn/Mmjax
002192   B6.129S7-Gt(ROSA)26Sor/J
006148   B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
026294   B6.Cg(129S)-Gt(ROSA)26Sortm2.2Ksvo/J
021071   B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
017983   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm9(tetO-Dnmt3b_i1)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
026930   B6.Cg-Gt(ROSA)26Sortm1.1(CAG-tdTomato,-EGFP)Pjen/J
026931   B6.Cg-Gt(ROSA)26Sortm1.2(CAG-tdTomato,-EGFP)Pjen/J
026932   B6.Cg-Gt(ROSA)26Sortm1.3(CAG-tdTomato,-EGFP)Pjen/J
007914   B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007920   B6.Cg-Gt(ROSA)26Sortm2(CAG-EYFP)Hze/J
012567   B6.Cg-Gt(ROSA)26Sortm27.1(CAG-COP4*H134R/tdTomato)Hze/J
007903   B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J
024109   B6.Cg-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
014648   B6.Cg-Gt(ROSA)26Sortm37(H1/tetO-RNAi:Taz)Arte/ZkhuJ
021188   B6.Cg-Gt(ROSA)26Sortm40.1(CAG-aop3/EGFP)Hze/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
025106   B6.Cg-Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/J
025109   B6.Cg-Gt(ROSA)26Sortm80.1(CAG-COP4*L132C/EYFP)Hze/J
007909   B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
024179   B6;129-Gt(ROSA)26Sortm1(Actb-T,-GFP)Dalco/J
017455   B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R,-tdTomato)Gfng/J
024857   B6;129-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
010527   B6;129-Gt(ROSA)26Sortm1(DTA)Mrc/J
016262   B6;129-Gt(ROSA)26Sortm1(Foxo1/GFP)Jke/J
017962   B6;129-Gt(ROSA)26Sortm1(RAC1*)Jkis/J
008883   B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
021847   B6;129-Gt(ROSA)26Sortm1Ytchn/J
008889   B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ
009253   B6;129-Gt(ROSA)26Sortm2Nat/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
008886   B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
021429   B6;129-Gt(ROSA)26Sortm4(CAG-GFP*)Nat/J
021039   B6;129-Gt(ROSA)26Sortm5(CAG-Sun1/sfGFP)Nat/J
023843   B6;129-Gt(ROSA)26Sortm6(Fzd6)Nat/J
010523   B6;129P2-Gt(ROSA)26Sortm1(CAG-ALPP)Fawa/J
024708   B6;129P2-Gt(ROSA)26Sortm1(CAG-RABVgp4,-TVA)Arenk/J
002073   B6;129S-Gt(ROSA)26Sor/J
018385   B6;129S-Gt(ROSA)26Sortm1(CAG-COX8A/Dendra2)Dcc/J
022516   B6;129S-Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/J
013206   B6;129S-Gt(ROSA)26Sortm1(NOTCH3*R1031C)Sat/Mmjax
018397   B6;129S-Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/J
023139   B6;129S-Gt(ROSA)26Sortm1.1Ksvo/J
024846   B6;129S-Gt(ROSA)26Sortm2.1Ksvo/J
012569   B6;129S-Gt(ROSA)26Sortm32(CAG-COP4*H134R/EYFP)Hze/J
012570   B6;129S-Gt(ROSA)26Sortm34.1(CAG-Syp/tdTomato)Hze/J
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
014538   B6;129S-Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/J
014539   B6;129S-Gt(ROSA)26Sortm39(CAG-hop/EYFP)Hze/J
021875   B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J
021876   B6;129S-Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/J
024105   B6;129S-Gt(ROSA)26Sortm95.1(CAG-GCaMP6f)Hze/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004598   B6;129S4-Gt(ROSA)26Sortm2Dym/J
007670   B6;129S4-Gt(ROSA)26Sortm3(phiC31*)Sor/J
024750   B6;129S4-Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/J
023035   B6;129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
016999   B6;129S6-Gt(ROSA)26Sortm1(rtTA2S*M2)Whsu/J
007908   B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J
007905   B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J
024106   B6;129S6-Gt(ROSA)26Sortm96(CAG-GCaMP6s)Hze/J
026175   B6J.129(B6N)-Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/J
026179   B6J.129(Cg)-Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
026219   B6N.129-Gt(ROSA)26Sortm1(CAG-CHRM4*,-mCitrine)Ute/J
019101   B6N.129S4(B6)-Gt(ROSA)26Sortm1Sor/CjDswJ
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
019016   B6N.129S6(Cg)-Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
023537   B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/J
026220   B6N;129-Gt(ROSA)26Sortm2(CAG-CHRM3*,-mCitrine)Ute/J
026261   B6N;129-Gt(ROSA)26Sortm3(CAG-Chrm3*,-mCitrine)Ute/J
025701   B6N;129S1-Gt(ROSA)26Sortm1(Grem1)Svok/J
019120   BALB/c-Gt(ROSA)26Sortm10(Lmp1)Rsky/J
009670   C.129P2(B6)-Gt(ROSA)26Sortm1(DTA)Lky/J
008603   C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J
002955   C.129S7-Gt(ROSA)26Sor/J
025322   C57BL/6-Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple/J
007900   C57BL/6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
008517   C57BL/6-Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky/J
012637   C57BL/6-Gt(ROSA)26Sortm5(Map3k14)Rsky/J
012638   C57BL/6-Gt(ROSA)26Sortm6(Map3k14*)Rsky/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
020458   C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky/J
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
008040   CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
026862   D2.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/SjJ
026863   D2.129S4(B6)-Gt(ROSA)26Sortm1Sor/SjJ
009427   FVB.129S4(B6)-Gt(ROSA)26Sortm1Sor/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
016977   FVB.129S6-Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
010920   FVB;129P2-Gt(ROSA)26Sortm1.1(birA)Mejr/J
016603   NOD.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/DvsJ
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
010675   STOCK Gt(ROSA)26Sortm1(CAG-EGFP)Fsh/Mmjax
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
022793   STOCK Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/J
023451   STOCK Gt(ROSA)26Sortm1(Luc)Kael Tg(UBC-CCR5,-CD4)19Mnz/J
008159   STOCK Gt(ROSA)26Sortm1(Notch1)Dam/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
018121   STOCK Gt(ROSA)26Sortm1(birA)Mejr Gata4tm3.1Wtp/J
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
008600   STOCK Gt(ROSA)26Sortm1(tTA)Roos/J
010701   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP)Fsh/Mmjax
022386   STOCK Gt(ROSA)26Sortm1.1(CAG-EGFP/Rpl10a,-birA)Wtp/J
024858   STOCK Gt(ROSA)26Sortm1.1(CAG-cas9,-EGFP)Fezh/J
025983   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Mef2ctm1.1Wtp/Mmjax
025977   STOCK Gt(ROSA)26Sortm1.1(birA)Mejr Zfpm2tm1.1Wtp /Mmjax
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
025671   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(tetO-Fgf10)1Jaw/SpdlJ
024746   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Hprttm1(tetO-Dkk1)Spdl Tg(TCF/Lef1-lacZ)34Efu/J
010812   STOCK Gt(ROSA)26Sortm1.2(CAG-EGFP)Fsh/Mmjax
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
023898   STOCK Gt(ROSA)26Sortm11.1(Setd5-GFP)Mgn/Mmjax
026570   STOCK Gt(ROSA)26Sortm1Embph/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018906   STOCK Gt(ROSA)26Sortm3(CAG-FLPo/ERT2)Alj/J
013124   STOCK Gt(ROSA)26Sortm3(Gli3)Amc/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
009674   STOCK Gt(ROSA)26Sortm4(HIF2A*)Kael/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
012266   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo/J
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
013123   STOCK Gt(ROSA)26Sortm6(Gli1)Amc/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
025982   STOCK Rbpjtm1.1Wtp Gt(ROSA)26Sortm1.1birA)Mejr/Mmjax
007577   STOCK Tg(Gt(ROSA)26Sor-BCHE*G117H)837Loc/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
View Strains carrying other alleles of Gt(ROSA)26Sor     (184 strains)

Additional Web Information

FLP-FRT Systems

Information about the Rosa26 locus on the Soriano lab web page


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
FLP-FRT System
      FLP Recombinase Expression
      FLP Recombinase Expression: Germline/Embryonic Expression
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: FLP recombinase

FLP related

Research Tools
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: FLP recombinase

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Gt(ROSA)26Sortm1(FLP1)Dym
Allele Name targeted mutation 1, Susan Dymecki
Allele Type Targeted (cre- or Flp-expressing)
Common Name(s) CAGGS-Flpe; FLP; FLP deleter; FLPe; FLPeR; R26Fki; ROSA26::FLPe knock in; ROSA26Fki; flipper;
Mutation Made By Susan Dymecki,   Harvard Medical School
Strain of Origin129S4/SvJaeSor
ES Cell Line NameAK7
ES Cell Line Strain129S4/SvJaeSor
Site of Expressionconstitutive expression of FLP1 recombinase from preimplantation onward and in most tissue types (including cells of the developing germ line)
Expressed Gene FLP, FLP recombinase, Saccharomyces cerevisiae
FLP recombinase is an enzyme derived from Saccharomyces cerevisiae that specifically recognizes a 34 base pair FLP recombinase target (FRT) sequence. FLP has been shown to effectively mediate the excision of DNA located between similarly oriented FRT sites. After the excision event, DNA ends recombine leaving a single FRT site in place of the intervening sequence. DNA located between oppositely orientated FRT sites is inverted rather than deleted.
Driver Note Gt(ROSA)26Sor
Molecular Note An enhanced flp cassette containing a splice acceptor site was ligated to a downstream PGK-neo cassette and inserted at the endogenous locus. Efficient frt-specific recombination in transgenic mice carrying a reporter gene was reported to reflect constituitive expression of the Gt(ROSA)26Sor from preimplantation onward. [MGI Ref ID J:66893] [MGI Ref ID J:92442]
Gene Symbol and Name Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Chromosome 6
Gene Common Name(s) AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; SETD5-AS1; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26;


Genotyping Information

Genotyping Protocols

Gt(ROSA)26Sortm1(FLP1)Dym, High Resolution Melting
Gt(ROSA)26Sortm1(FLP1)Dym, Separated PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Farley FW; Soriano P; Steffen LS; Dymecki SM. 2000. Widespread recombinase expression using FLPeR (Flipper) mice Genesis 28(3-4):106-10. [PubMed: 11105051]  [MGI Ref ID J:66893]

Additional References

Gt(ROSA)26Sortm1(FLP1)Dym related

Affar el B; Gay F; Shi Y; Liu H; Huarte M; Wu S; Collins T; Li E; Shi Y. 2006. Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol 26(9):3565-81. [PubMed: 16611997]  [MGI Ref ID J:108369]

Alves CH; Sanz Sanz A; Park B; Pellissier LP; Tanimoto N; Beck SC; Huber G; Murtaza M; Richard F; Sridevi Gurubaran I; Garcia Garrido M; Levelt CN; Rashbass P; Le Bivic A; Seeliger MW; Wijnholds J. 2013. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22(1):35-50. [PubMed: 23001562]  [MGI Ref ID J:191149]

Amendola E; Zhan Y; Mattucci C; Castroflorio E; Calcagno E; Fuchs C; Lonetti G; Silingardi D; Vyssotski AL; Farley D; Ciani E; Pizzorusso T; Giustetto M; Gross CT. 2014. Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder. PLoS One 9(5):e91613. [PubMed: 24838000]  [MGI Ref ID J:209635]

Amleh A; Nair SJ; Sun J; Sutherland A; Hasty P; Li R. 2009. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS ONE 4(4):e5034. [PubMed: 19340312]  [MGI Ref ID J:148508]

Anderson MP; Mochizuki T; Xie J; Fischler W; Manger JP; Talley EM; Scammell TE; Tonegawa S. 2005. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A 102(5):1743-8. [PubMed: 15677322]  [MGI Ref ID J:96099]

Astapova I; Lee LJ; Morales C; Tauber S; Bilban M; Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105(49):19544-9. [PubMed: 19052228]  [MGI Ref ID J:142045]

Awatramani R; Soriano P; Mai JJ; Dymecki S. 2001. An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat Genet 29(3):257-9. [PubMed: 11687793]  [MGI Ref ID J:72406]

Awatramani R; Soriano P; Rodriguez C; Mai JJ; Dymecki SM. 2003. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35(1):70-5. [PubMed: 12923530]  [MGI Ref ID J:128980]

Backman CM; Malik N; Zhang Y; Shan L; Grinberg A; Hoffer BJ; Westphal H; Tomac AC. 2006. Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis 44(8):383-90. [PubMed: 16865686]  [MGI Ref ID J:114466]

Backman CM; Zhang Y; Malik N; Shan L; Hoffer BJ; Westphal H; Tomac AC. 2009. Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice. J Neurosci Methods 176(1):16-23. [PubMed: 18801387]  [MGI Ref ID J:159515]

Barbarese E; Ifrim MF; Hsieh L; Guo C; Tatavarty V; Maggipinto MJ; Korza G; Tutolo JW; Giampetruzzi A; Le H; Ma XM; Levine E; Bishop B; Kim DO; Kuwada S; Carson JH. 2013. Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation. PLoS One 8(8):e69989. [PubMed: 23936366]  [MGI Ref ID J:205779]

Barnes RM; Firulli BA; Conway SJ; Vincentz JW; Firulli AB. 2010. Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn 239(11):3086-97. [PubMed: 20882677]  [MGI Ref ID J:165398]

Barnes RM; Firulli BA; Vandusen NJ; Morikawa Y; Conway SJ; Cserjesi P; Vincentz JW; Firulli AB. 2011. Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res 108(8):940-9. [PubMed: 21350214]  [MGI Ref ID J:171088]

Barrell WB; Szabo-Rogers HL; Liu KJ. 2012. Novel reporter alleles of GSK-3alpha and GSK-3beta. PLoS One 7(11):e50422. [PubMed: 23185619]  [MGI Ref ID J:195008]

Beutler LR; Wanat MJ; Quintana A; Sanz E; Bamford NS; Zweifel LS; Palmiter RD. 2011. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A 108(10):4206-11. [PubMed: 21368124]  [MGI Ref ID J:170830]

Biressi S; Bjornson CR; Carlig PM; Nishijo K; Keller C; Rando TA. 2013. Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells. Dev Biol 379(2):195-207. [PubMed: 23639729]  [MGI Ref ID J:199482]

Birkenfeld AL; Lee HY; Guebre-Egziabher F; Alves TC; Jurczak MJ; Jornayvaz FR; Zhang D; Hsiao JJ; Martin-Montalvo A; Fischer-Rosinsky A; Spranger J; Pfeiffer AF; Jordan J; Fromm MF; Konig J; Lieske S; Carmean CM; Frederick DW; Weismann D; Knauf F; IrustaPM; De Cabo R; Helfand SL; Samuel VT; Shulman GI. 2011. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab 14(2):184-95. [PubMed: 21803289]  [MGI Ref ID J:176732]

Bisson N; Ruston J; Jeansson M; Vanderlaan R; Hardy WR; Du J; Hussein SM; Coward RJ; Quaggin SE; Pawson T. 2012. The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS One 7(11):e50996. [PubMed: 23226445]  [MGI Ref ID J:195444]

Bochner R; Ziv Y; Zeevi D; Donyo M; Abraham L; Ashery-Padan R; Ast G. 2013. Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. Hum Mol Genet 22(14):2785-94. [PubMed: 23515154]  [MGI Ref ID J:198544]

Boo K; Baek SH; Lee H. 2014. Pontin is required for pre-TCR signaling at the beta-selection checkpoint in T cell development. Biochem Biophys Res Commun 447(1):44-50. [PubMed: 24680824]  [MGI Ref ID J:219468]

Bothmer A; Rommel PC; Gazumyan A; Polato F; Reczek CR; Muellenbeck MF; Schaetzlein S; Edelmann W; Chen PL; Brosh RM Jr; Casellas R; Ludwig T; Baer R; Nussenzweig A; Nussenzweig MC; Robbiani DF. 2013. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med 210(1):115-23. [PubMed: 23254285]  [MGI Ref ID J:194603]

Bowman-Colin C; Xia B; Bunting S; Klijn C; Drost R; Bouwman P; Fineman L; Chen X; Culhane AC; Cai H; Rodig SJ; Bronson RT; Jonkers J; Nussenzweig A; Kanellopoulou C; Livingston DM. 2013. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A 110(21):8632-7. [PubMed: 23657012]  [MGI Ref ID J:197442]

Boyer A; Lapointe E; Zheng X; Cowan RG; Li H; Quirk SM; Demayo FJ; Richards JS; Boerboom D. 2010. WNT4 is required for normal ovarian follicle development and female fertility. FASEB J 24(8):3010-25. [PubMed: 20371632]  [MGI Ref ID J:162337]

Bradley CK; Norton CR; Chen Y; Han X; Booth CJ; Yoon JK; Krebs LT; Gridley T. 2013. The snail family gene snai3 is not essential for embryogenesis in mice. PLoS One 8(6):e65344. [PubMed: 23762348]  [MGI Ref ID J:198115]

Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. [PubMed: 19515977]  [MGI Ref ID J:150043]

Carbe C; Hertzler-Schaefer K; Zhang X. 2012. The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol 363(1):320-9. [PubMed: 22240097]  [MGI Ref ID J:182769]

Carter ME; Soden ME; Zweifel LS; Palmiter RD. 2013. Genetic identification of a neural circuit that suppresses appetite. Nature 503(7474):111-4. [PubMed: 24121436]  [MGI Ref ID J:206070]

Cazzin C; Zanderigo F; Costantini VJ; Zambello E; Ring CJ; Morrison AD; Caberlotto L; Kew JN. 2010. Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice. J Neurosci Methods 193(2):254-63. [PubMed: 20832426]  [MGI Ref ID J:168155]

Chan HY; V S; Xing X; Kraus P; Yap SP; Ng P; Lim SL; Lufkin T. 2011. Comparison of IRES and F2A-Bases locus-specific multicistronic expression in stable mouse lines PLoS ONE 6(12):e28885. [PubMed: 22216134]  [MGI Ref ID J:178821]

Chang HY; Locker J; Lu R; Schuster VL. 2010. Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation 121(4):529-36. [PubMed: 20083684]  [MGI Ref ID J:168442]

Chatterjee S; Kraus P; Sivakamasundari V; Xing X; Yap SP; Jie S; Lufkin T. 2013. A conditional mouse line for lineage tracing of Sox9 loss-of-function cells using enhanced green fluorescent protein. Biotechnol Lett 35(12):1991-6. [PubMed: 23907671]  [MGI Ref ID J:207801]

Chatzi C; Cunningham TJ; Duester G. 2013. Investigation of retinoic acid function during embryonic brain development using retinaldehyde-rescued Rdh10 knockout mice. Dev Dyn 242(9):1056-65. [PubMed: 23765990]  [MGI Ref ID J:199565]

Chen CM; Bentham J; Cosgrove C; Braganca J; Cuenda A; Bamforth SD; Schneider JE; Watkins H; Keavney B; Davies B; Bhattacharya S. 2012. Functional significance of SRJ domain mutations in CITED2. PLoS One 7(10):e46256. [PubMed: 23082118]  [MGI Ref ID J:192202]

Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261]  [MGI Ref ID J:132329]

Chen PP; Patel JR; Powers PA; Fitzsimons DP; Moss RL. 2012. Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice. Circulation 126(10):1194-205. [PubMed: 22829020]  [MGI Ref ID J:202199]

Chen WV; Delrow J; Corrin PD; Frazier JP; Soriano P. 2004. Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis. Nat Genet 36(3):304-12. [PubMed: 14981515]  [MGI Ref ID J:95727]

Cheng CY; Hwang CI; Corney DC; Flesken-Nikitin A; Jiang L; Oner GM; Munroe RJ; Schimenti JC; Hermeking H; Nikitin AY. 2014. miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell Rep 6(6):1000-7. [PubMed: 24630988]  [MGI Ref ID J:211711]

Chong MM; Simpson N; Ciofani M; Chen G; Collins A; Littman DR. 2010. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev 24(7):659-69. [PubMed: 20360383]  [MGI Ref ID J:158962]

Cohen P; Levy JD; Zhang Y; Frontini A; Kolodin DP; Svensson KJ; Lo JC; Zeng X; Ye L; Khandekar MJ; Wu J; Gunawardana SC; Banks AS; Camporez JP; Jurczak MJ; Kajimura S; Piston DW; Mathis D; Cinti S; Shulman GI; Seale P; Spiegelman BM. 2014. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell 156(1-2):304-16. [PubMed: 24439384]  [MGI Ref ID J:208683]

Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. [PubMed: 22374917]  [MGI Ref ID J:187484]

Cui X; Wang Y; Tang Y; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju S; Liu G; Yang H. 2011. Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet 20(15):3022-30. [PubMed: 21551454]  [MGI Ref ID J:173404]

Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. [PubMed: 21602802]  [MGI Ref ID J:172746]

Dakic A; Metcalf D; Di Rago L; Mifsud S; Wu L; Nutt SL. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201(9):1487-502. [PubMed: 15867096]  [MGI Ref ID J:98188]

De Fazio S; Bartonicek N; Di Giacomo M; Abreu-Goodger C; Sankar A; Funaya C; Antony C; Moreira PN; Enright AJ; O'Carroll D. 2011. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature 480(7376):259-63. [PubMed: 22020280]  [MGI Ref ID J:184034]

Deng M; Pan L; Xie X; Gan L. 2010. Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol 338(1):38-49. [PubMed: 19913004]  [MGI Ref ID J:156733]

Di Giacomo M; Comazzetto S; Saini H; De Fazio S; Carrieri C; Morgan M; Vasiliauskaite L; Benes V; Enright AJ; O'Carroll D. 2013. Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis. Mol Cell 50(4):601-8. [PubMed: 23706823]  [MGI Ref ID J:199259]

Dong Y; Du X; Ye J; Han M; Xu T; Zhuang Y; Tao W. 2009. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol 183(6):3865-72. [PubMed: 19692642]  [MGI Ref ID J:152323]

Dougherty KJ; Zagoraiou L; Satoh D; Rozani I; Doobar S; Arber S; Jessell TM; Kiehn O. 2013. Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons. Neuron 80(4):920-33. [PubMed: 24267650]  [MGI Ref ID J:209344]

Dubielecka PM; Ladwein KI; Xiong X; Migeotte I; Chorzalska A; Anderson KV; Sawicki JA; Rottner K; Stradal TE; Kotula L. 2011. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A 108(17):7022-7. [PubMed: 21482783]  [MGI Ref ID J:171342]

Dudok JJ; Sanz AS; Lundvig DM; Wijnholds J. 2013. MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex. J Neurosci 33(19):8518-27. [PubMed: 23658188]  [MGI Ref ID J:198427]

Dzhagalov I; St John A; He YW. 2007. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109(4):1620-6. [PubMed: 17062731]  [MGI Ref ID J:137502]

Ecker JL; Dumitrescu ON; Wong KY; Alam NM; Chen SK; LeGates T; Renna JM; Prusky GT; Berson DM; Hattar S. 2010. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67(1):49-60. [PubMed: 20624591]  [MGI Ref ID J:167871]

Emery B; Agalliu D; Cahoy JD; Watkins TA; Dugas JC; Mulinyawe SB; Ibrahim A; Ligon KL; Rowitch DH; Barres BA. 2009. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 138(1):172-85. [PubMed: 19596243]  [MGI Ref ID J:150563]

Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. [PubMed: 18378898]  [MGI Ref ID J:134264]

Fan X; Hou N; Fan K; Yuan J; Mo X; Deng Y; Wan Y; Teng Y; Yang X; Wu X. 2012. Geft is dispensable for the development of the second heart field. BMB Rep 45(3):153-8. [PubMed: 22449701]  [MGI Ref ID J:183551]

Fan X; Liu X; Hao S; Wang B; Robinson ML; Monnier VM. 2012. The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One 7(11):e50832. [PubMed: 23226398]  [MGI Ref ID J:194778]

Fan Y; Menon RK; Cohen P; Hwang D; Clemens T; DiGirolamo DJ; Kopchick JJ; Le Roith D; Trucco M; Sperling MA. 2009. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284(30):19937-44. [PubMed: 19460757]  [MGI Ref ID J:152627]

Fan Y; Rudert WA; Grupillo M; He J; Sisino G; Trucco M. 2009. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28(18):2812-24. [PubMed: 19680229]  [MGI Ref ID J:152798]

Farago AF; Awatramani RB; Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50(2):205-18. [PubMed: 16630833]  [MGI Ref ID J:133039]

Favaro R; Valotta M; Ferri AL; Latorre E; Mariani J; Giachino C; Lancini C; Tosetti V; Ottolenghi S; Taylor V; Nicolis SK. 2009. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10):1248-56. [PubMed: 19734891]  [MGI Ref ID J:154650]

Feng JQ; Scott G; Guo D; Jiang B; Harris M; Ward T; Ray M; Bonewald LF; Harris SE; Mishina Y. 2008. Generation of a conditional null allele for Dmp1 in mouse. Genesis 46(2):87-91. [PubMed: 18257058]  [MGI Ref ID J:135314]

Fernandez-Valdivia R; Jeong J; Mukherjee A; Soyal SM; Li J; Ying Y; Demayo FJ; Lydon JP. 2010. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis 48(2):106-13. [PubMed: 20029965]  [MGI Ref ID J:158406]

Flodby P; Borok Z; Banfalvi A; Zhou B; Gao D; Minoo P; Ann DK; Morrisey EE; Crandall ED. 2010. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol 43(2):173-8. [PubMed: 19767448]  [MGI Ref ID J:174124]

Foulkes T; Nassar MA; Lane T; Matthews EA; Baker MD; Gerke V; Okuse K; Dickenson AH; Wood JN. 2006. Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci 26(41):10499-507. [PubMed: 17035534]  [MGI Ref ID J:113256]

Fragoso R; Mao T; Wang S; Schaffert S; Gong X; Yue S; Luong R; Min H; Yashiro-Ohtani Y; Davis M; Pear W; Chen CZ. 2012. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 8(8):e1002855. [PubMed: 22916024]  [MGI Ref ID J:188125]

Fu C; Ess KC. 2013. Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Genesis 51(4):284-92. [PubMed: 23359422]  [MGI Ref ID J:195049]

Gabel LA; Marin I; LoTurco JJ; Che A; Murphy C; Manglani M; Kass S. 2011. Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice. Genes Brain Behav 10(8):868-75. [PubMed: 21883923]  [MGI Ref ID J:188826]

Gao X; Shin YH; Li M; Wang F; Tong Q; Zhang P. 2010. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5(11):e14005. [PubMed: 21103374]  [MGI Ref ID J:166984]

Gehman LT; Stoilov P; Maguire J; Damianov A; Lin CH; Shiue L; Ares M Jr; Mody I; Black DL. 2011. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43(7):706-11. [PubMed: 21623373]  [MGI Ref ID J:176189]

Gladman JT; Bebee TW; Edwards C; Wang X; Sahenk Z; Rich MM; Chandler DS. 2010. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype. Hum Mol Genet 19(21):4239-52. [PubMed: 20705738]  [MGI Ref ID J:164889]

Golan N; Kartvelishvily E; Spiegel I; Salomon D; Sabanay H; Rechav K; Vainshtein A; Frechter S; Maik-Rachline G; Eshed-Eisenbach Y; Momoi T; Peles E. 2013. Genetic deletion of Cadm4 results in myelin abnormalities resembling charcot-marie-tooth neuropathy. J Neurosci 33(27):10950-61. [PubMed: 23825401]  [MGI Ref ID J:199632]

Gomez TS; Gorman JA; de Narvajas AA; Koenig AO; Billadeau DD. 2012. Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell 23(16):3215-28. [PubMed: 22718907]  [MGI Ref ID J:199703]

Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G. 2006. Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-8. [PubMed: 16354690]  [MGI Ref ID J:104114]

Grimm SL; Ward RD; Obr AE; Franco HL; Fernandez-Valdivia R; Kim JS; Roberts JM; Jeong JW; DeMayo FJ; Lydon JP; Edwards DP; Weigel NL. 2014. A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol 28(12):2025-37. [PubMed: 25333515]  [MGI Ref ID J:218283]

Gu P; Qi X; Zhou Y; Wang Y; Gao X. 2012. Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis 50(5):429-36. [PubMed: 21998041]  [MGI Ref ID J:184036]

Gubbels Bupp MR; Edwards B; Guo C; Wei D; Chen G; Wong B; Masteller E; Peng SL. 2009. T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol 39(11):2991-2999. [PubMed: 19658095]  [MGI Ref ID J:154205]

Guo F; Ma Y; Kadegowda AK; Xie P; Liu G; Liu X; Miao H; Ou J; Su X; Zheng Z; Xue B; Shi H; Yu L. 2013. Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice. J Lipid Res 54(8):2109-20. [PubMed: 23733885]  [MGI Ref ID J:199570]

Hamada M; Haeger A; Jeganathan KB; van Ree JH; Malureanu L; Walde S; Joseph J; Kehlenbach RH; van Deursen JM. 2011. Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol 194(4):597-612. [PubMed: 21859863]  [MGI Ref ID J:176959]

He F; Popkie AP; Xiong W; Li L; Wang Y; Phiel CJ; Chen Y. 2010. Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn 239(12):3235-46. [PubMed: 20981831]  [MGI Ref ID J:166721]

He H; Mahnke AH; Doyle S; Fan N; Wang CC; Hall BJ; Tang YP; Inglis FM; Chen C; Erickson JD. 2012. Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in spatial learning. J Neurosci 32(45):15886-901. [PubMed: 23136427]  [MGI Ref ID J:192240]

Hertveldt V; Louryan S; van Reeth T; Dreze P; van Vooren P; Szpirer J; Szpirer C. 2008. The development of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn 237(4):883-92. [PubMed: 18297738]  [MGI Ref ID J:132771]

Heyer MP; Pani AK; Smeyne RJ; Kenny PJ; Feng G. 2012. Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice. J Neurosci 32(32):10887-10894. [PubMed: 22875923]  [MGI Ref ID J:186618]

Hippenmeyer S; Youn YH; Moon HM; Miyamichi K; Zong H; Wynshaw-Boris A; Luo L. 2010. Genetic mosaic dissection of lis1 and ndel1 in neuronal migration. Neuron 68(4):695-709. [PubMed: 21092859]  [MGI Ref ID J:166047]

Hirata T; Li P; Lanuza GM; Cocas LA; Huntsman MM; Corbin JG. 2009. Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Nat Neurosci 12(2):141-9. [PubMed: 19136974]  [MGI Ref ID J:146178]

Hnasko TS; Chuhma N; Zhang H; Goh GY; Sulzer D; Palmiter RD; Rayport S; Edwards RH. 2010. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65(5):643-56. [PubMed: 20223200]  [MGI Ref ID J:167767]

Hoch RV; Soriano P. 2006. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133(4):663-73. [PubMed: 16421190]  [MGI Ref ID J:105920]

Hockemeyer D; Daniels JP; Takai H; de Lange T. 2006. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126(1):63-77. [PubMed: 16839877]  [MGI Ref ID J:112185]

Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618]  [MGI Ref ID J:117666]

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Wolfler A; Danen-van Oorschot AA; Haanstra JR; Valkhof M; Bodner C; Vroegindeweij E; van Strien P; Novak A; Cupedo T; Touw IP. 2010. Lineage-instructive function of C/EBPalpha in multipotent hematopoietic cells and early thymic progenitors. Blood 116(20):4116-25. [PubMed: 20807890]  [MGI Ref ID J:166620]

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Xia A; Gao SS; Yuan T; Osborn A; Bress A; Pfister M; Maricich SM; Pereira FA; Oghalai JS. 2010. Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation. Dis Model Mech 3(3-4):209-23. [PubMed: 20142329]  [MGI Ref ID J:160851]

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Xie R; Jiang R; Chen D. 2011. Generation of Axin1 conditional mutant mice. Genesis 49(2):98-102. [PubMed: 21344612]  [MGI Ref ID J:169694]

Xiong J; Onal M; Jilka RL; Weinstein RS; Manolagas SC; O'Brien CA. 2011. Matrix-embedded cells control osteoclast formation. Nat Med 17(10):1235-41. [PubMed: 21909103]  [MGI Ref ID J:177558]

Xu J; Krebs LT; Gridley T. 2010. Generation of mice with a conditional null allele of the Jagged2 gene. Genesis 48(6):390-3. [PubMed: 20533406]  [MGI Ref ID J:163652]

Xu K; Nieuwenhuis E; Cohen BL; Wang W; Canty AJ; Danska JS; Coultas L; Rossant J; Wu MY; Piscione TD; Nagy A; Gossler A; Hicks GG; Hui CC; Henkelman RM; Yu LX; Sled JG; Gridley T; Egan SE. 2010. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol 298(1):L45-56. [PubMed: 19897741]  [MGI Ref ID J:155893]

Yamamoto M; Shook NA; Kanisicak O; Yamamoto S; Wosczyna MN; Camp JR; Goldhamer DJ. 2009. A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis 47(2):107-14. [PubMed: 19165827]  [MGI Ref ID J:147304]

Yan H; Kong D; Ge X; Gao X; Han X. 2011. Generation of conditional knockout alleles for PRL-3. J Biomed Res 25(6):438-43. [PubMed: 23554722]  [MGI Ref ID J:197019]

Yang J; Brown A; Ellisor D; Paul E; Hagan N; Zervas M. 2013. Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development 140(6):1342-52. [PubMed: 23444360]  [MGI Ref ID J:194842]

Yang S; Li YP; Liu T; He X; Yuan X; Li C; Cao J; Kim Y. 2013. Mx1-Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype. Genesis 51(3):201-9. [PubMed: 23349096]  [MGI Ref ID J:194057]

Yang W; Guo D; Harris MA; Cui Y; Gluhak-Heinrich J; Wu J; Chen XD; Skinner C; Nyman JS; Edwards JR; Mundy GR; Lichtler A; Kream BE; Rowe DW; Kalajzic I; David V; Quarles DL; Villareal D; Scott G; Ray M; Liu S; Martin JF; Mishina Y; Harris SE. 2013. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci 126(Pt 18):4085-98. [PubMed: 23843612]  [MGI Ref ID J:210409]

Yang XO; Zhang H; Kim BS; Niu X; Peng J; Chen Y; Kerketta R; Lee YH; Chang SH; Corry DB; Wang D; Watowich SS; Dong C. 2013. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 14(7):732-40. [PubMed: 23727894]  [MGI Ref ID J:204829]

Yap SP; Xing X; Kraus P; Sivakamasundari V; Chan HY; Lufkin T. 2011. Generation of mice with a novel conditional null allele of the Sox9 gene. Biotechnol Lett 33(8):1551-8. [PubMed: 21484342]  [MGI Ref ID J:176950]

Yokoi F; Dang MT; Mitsui S; Li J; Li Y. 2008. Motor Deficits and Hyperactivity in Cerebral Cortex-specific Dyt1 Conditional Knockout Mice. J Biochem 143(1):39-47. [PubMed: 17956903]  [MGI Ref ID J:130483]

Yokoi F; Dang MT; Mitsui S; Li Y. 2005. Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain. FEBS Lett 579(21):4822-8. [PubMed: 16099459]  [MGI Ref ID J:101332]

Yokoi F; Dang MT; Yang G; Li J; Doroodchi A; Zhou T; Li Y. 2012. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models. Behav Brain Res 227(1):12-20. [PubMed: 22040906]  [MGI Ref ID J:180682]

Yoshioka J; Imahashi K; Gabel SA; Chutkow WA; Burds AA; Gannon J; Schulze PC; MacGillivray C; London RE; Murphy E; Lee RT. 2007. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res 101(12):1328-38. [PubMed: 17916779]  [MGI Ref ID J:141487]

Zaid A; Roubtsova A; Essalmani R; Marcinkiewicz J; Chamberland A; Hamelin J; Tremblay M; Jacques H; Jin W; Davignon J; Seidah NG; Prat A. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 48(2):646-54. [PubMed: 18666258]  [MGI Ref ID J:169834]

Zeng H. 2011. Direct Data Submission 2011/10/17 MGI Direct Data Submission :.  [MGI Ref ID J:176570]

Zeng H; Hoover AN; Liu A. 2010. PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Dev Biol 339(2):418-28. [PubMed: 20067783]  [MGI Ref ID J:159120]

Zhang J; Kelley KL; Marshall SM; Davis MA; Wilson MD; Sawyer JK; Farese RV Jr; Brown JM; Rudel LL. 2012. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res 53(6):1144-52. [PubMed: 22460046]  [MGI Ref ID J:184908]

Zhang L; Zhou F; Han W; Shen B; Luo J; Shibuya M; He Y. 2010. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res 20(12):1319-31. [PubMed: 20697430]  [MGI Ref ID J:177405]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.
Mating SystemHomozygote x Homozygote         (Female x Male)   26-APR-10
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Gt(ROSA)26Sortm1(FLP1)Dym  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym x Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Gt(ROSA)26Sortm1(FLP1)Dym  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym x Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Terms of Use

Terms of Use

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- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.