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| This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
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Description
Strain Information
Former Names B6.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/JRainJ (Changed: 02-APR-09 ) Type Congenic; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 26-APR-10 Species laboratory mouse Generation N10+F8 (12-JUL-11)
Generation DefinitionsDonating Investigator Elaine W Raines and Carole L Wilson, Univ. Washington School of Medicine Description
Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wild type FLP at 37C and 40C, respectively. The Gt(ROSA)26Sor promoter drives expression from preimplantation onward and extensive target gene recombination can be achieved in most tissue types, including cells of the developing germ line. When bred with mice containing a frt-flanked sequence of interest, FLP-mediated recombination will result in deletion of the frt-flanked sequence(s) in the offspring. This FLP deleter strain may be useful for generating frt-FLP conditional mutations and serves as a source of FLP1-expressing primary cell lines.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
Homozygous males from The Jackson Laboratory strain 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J (Stock No. 003946) were purchased by Elaine W. Raines and Carole L. Wilson (University of Washington School of Medicine). Mutant males were backcrossed to C57BL/6J inbred females (see Stock No. 000664) for ten generations and then made homozygous prior to arrival at The Jackson Laboratory (as Stock No. 009086). The Y chromosome may not have been fixed to the genetic background during the backcross.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Gt(ROSA)26Sortm1(FLP1)Dym allele
003946 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J 016226 B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J View Strains carrying Gt(ROSA)26Sortm1(FLP1)Dym (2 strains)
Additional Web Information
FLP-FRT Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
FLP1 relatedResearch Tools
FLP-FRT System
FLP Recombinase Expression
FLP Recombinase Expression: Germline/Embryonic Expression
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: FLP recombinase
Research Tools
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: FLP recombinase
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Gt(ROSA)26Sortm1(FLP1)Dym | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Susan Dymecki | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | CAGGS-Flpe; FLP; FLP deleter; FLPe; FLPeR; R26Fki; ROSA26::FLPe knock in; ROSA26Fki; flipper; | ||
| Mutation Made By | Susan Dymecki, Harvard Medical School | ||
| Strain of Origin | 129S4/SvJaeSor | ||
| ES Cell Line Name | AK7 | ||
| ES Cell Line Strain | 129S4/SvJaeSor | ||
| Site of Expression | constitutive expression of FLP1 recombinase from preimplantation onward and in most tissue types (including cells of the developing germ line) | ||
| Expressed Gene | FLP1, FLP1 recombinase, Saccharomyces cerevisiae | ||
| FLP1 recombinase is an enzyme derived from Saccharomyces cerevisiae that specifically recognizes a 34 base pair FLP1 recombinase target (FRT) sequence. FLP1 has been shown to effectively mediate the excision of DNA located between similarly oriented FRT sites. After the excision event, DNA ends recombine leaving a single FRT site in place of the intervening sequence. DNA located between oppositely orientated FRT sites is inverted rather than deleted. | |||
| Driver Note | Gt(ROSA)26Sor | ||
| Molecular Note | An enhanced flp cassette containing a splice acceptor site was ligated to a downstream PGK-neo cassette and inserted at the endogenous locus. Efficient frt-specific recombination in transgenic mice carrying a reporter gene was reported to reflect constituitive expression of the Gt(ROSA)26Sor from preimplantation onward. [MGI Ref ID J:66893] [MGI Ref ID J:92442] | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sortm1(FLP1)Dym,Separated MCA
Gt(ROSA)26Sortm1(FLP1)Dym, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Farley FW; Soriano P; Steffen LS; Dymecki SM. 2000. Widespread recombinase expression using FLPeR (Flipper) mice Genesis 28(3-4):106-10. [PubMed: 11105051] [MGI Ref ID J:66893]
Additional References
Gt(ROSA)26Sortm1(FLP1)Dym relatedAffar el B; Gay F; Shi Y; Liu H; Huarte M; Wu S; Collins T; Li E; Shi Y. 2006. Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol 26(9):3565-81. [PubMed: 16611997] [MGI Ref ID J:108369]
Alves CH; Sanz Sanz A; Park B; Pellissier LP; Tanimoto N; Beck SC; Huber G; Murtaza M; Richard F; Sridevi Gurubaran I; Garcia Garrido M; Levelt CN; Rashbass P; Le Bivic A; Seeliger MW; Wijnholds J. 2013. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22(1):35-50. [PubMed: 23001562] [MGI Ref ID J:191149]
Amleh A; Nair SJ; Sun J; Sutherland A; Hasty P; Li R. 2009. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS ONE 4(4):e5034. [PubMed: 19340312] [MGI Ref ID J:148508]
Anderson MP; Mochizuki T; Xie J; Fischler W; Manger JP; Talley EM; Scammell TE; Tonegawa S. 2005. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A 102(5):1743-8. [PubMed: 15677322] [MGI Ref ID J:96099]
Astapova I; Lee LJ; Morales C; Tauber S; Bilban M; Hollenberg AN. 2008. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105(49):19544-9. [PubMed: 19052228] [MGI Ref ID J:142045]
Awatramani R; Soriano P; Mai JJ; Dymecki S. 2001. An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat Genet 29(3):257-9. [PubMed: 11687793] [MGI Ref ID J:72406]
Awatramani R; Soriano P; Rodriguez C; Mai JJ; Dymecki SM. 2003. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet 35(1):70-5. [PubMed: 12923530] [MGI Ref ID J:128980]
Backman CM; Malik N; Zhang Y; Shan L; Grinberg A; Hoffer BJ; Westphal H; Tomac AC. 2006. Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis 44(8):383-90. [PubMed: 16865686] [MGI Ref ID J:114466]
Backman CM; Zhang Y; Malik N; Shan L; Hoffer BJ; Westphal H; Tomac AC. 2009. Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice. J Neurosci Methods 176(1):16-23. [PubMed: 18801387] [MGI Ref ID J:159515]
Barnes RM; Firulli BA; Conway SJ; Vincentz JW; Firulli AB. 2010. Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn 239(11):3086-97. [PubMed: 20882677] [MGI Ref ID J:165398]
Barnes RM; Firulli BA; Vandusen NJ; Morikawa Y; Conway SJ; Cserjesi P; Vincentz JW; Firulli AB. 2011. Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development. Circ Res 108(8):940-9. [PubMed: 21350214] [MGI Ref ID J:171088]
Barrell WB; Szabo-Rogers HL; Liu KJ. 2012. Novel reporter alleles of GSK-3alpha and GSK-3beta. PLoS One 7(11):e50422. [PubMed: 23185619] [MGI Ref ID J:195008]
Beutler LR; Wanat MJ; Quintana A; Sanz E; Bamford NS; Zweifel LS; Palmiter RD. 2011. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proc Natl Acad Sci U S A 108(10):4206-11. [PubMed: 21368124] [MGI Ref ID J:170830]
Birkenfeld AL; Lee HY; Guebre-Egziabher F; Alves TC; Jurczak MJ; Jornayvaz FR; Zhang D; Hsiao JJ; Martin-Montalvo A; Fischer-Rosinsky A; Spranger J; Pfeiffer AF; Jordan J; Fromm MF; Konig J; Lieske S; Carmean CM; Frederick DW; Weismann D; Knauf F; IrustaPM; De Cabo R; Helfand SL; Samuel VT; Shulman GI. 2011. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metab 14(2):184-95. [PubMed: 21803289] [MGI Ref ID J:176732]
Bisson N; Ruston J; Jeansson M; Vanderlaan R; Hardy WR; Du J; Hussein SM; Coward RJ; Quaggin SE; Pawson T. 2012. The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS One 7(11):e50996. [PubMed: 23226445] [MGI Ref ID J:195444]
Bothmer A; Rommel PC; Gazumyan A; Polato F; Reczek CR; Muellenbeck MF; Schaetzlein S; Edelmann W; Chen PL; Brosh RM Jr; Casellas R; Ludwig T; Baer R; Nussenzweig A; Nussenzweig MC; Robbiani DF. 2013. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med 210(1):115-23. [PubMed: 23254285] [MGI Ref ID J:194603]
Boyer A; Lapointe E; Zheng X; Cowan RG; Li H; Quirk SM; Demayo FJ; Richards JS; Boerboom D. 2010. WNT4 is required for normal ovarian follicle development and female fertility. FASEB J 24(8):3010-25. [PubMed: 20371632] [MGI Ref ID J:162337]
Bush JO; Soriano P. 2009. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev 23(13):1586-99. [PubMed: 19515977] [MGI Ref ID J:150043]
Carbe C; Hertzler-Schaefer K; Zhang X. 2012. The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol 363(1):320-9. [PubMed: 22240097] [MGI Ref ID J:182769]
Cazzin C; Zanderigo F; Costantini VJ; Zambello E; Ring CJ; Morrison AD; Caberlotto L; Kew JN. 2010. Adenoviral-mediated Cre expression effectively suppresses GlyT1 binding in the thalamic area of GlyT1 conditional knock-out mice. J Neurosci Methods 193(2):254-63. [PubMed: 20832426] [MGI Ref ID J:168155]
Chan HY; V S; Xing X; Kraus P; Yap SP; Ng P; Lim SL; Lufkin T. 2011. Comparison of IRES and F2A-Bases locus-specific multicistronic expression in stable mouse lines PLoS ONE 6(12):e28885. [PubMed: 22216134] [MGI Ref ID J:178821]
Chang HY; Locker J; Lu R; Schuster VL. 2010. Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation 121(4):529-36. [PubMed: 20083684] [MGI Ref ID J:168442]
Chen CM; Bentham J; Cosgrove C; Braganca J; Cuenda A; Bamforth SD; Schneider JE; Watkins H; Keavney B; Davies B; Bhattacharya S. 2012. Functional significance of SRJ domain mutations in CITED2. PLoS One 7(10):e46256. [PubMed: 23082118] [MGI Ref ID J:192202]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
Chen WV; Delrow J; Corrin PD; Frazier JP; Soriano P. 2004. Identification and validation of PDGF transcriptional targets by microarray-coupled gene-trap mutagenesis. Nat Genet 36(3):304-12. [PubMed: 14981515] [MGI Ref ID J:95727]
Chong MM; Simpson N; Ciofani M; Chen G; Collins A; Littman DR. 2010. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev 24(7):659-69. [PubMed: 20360383] [MGI Ref ID J:158962]
Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. [PubMed: 22374917] [MGI Ref ID J:187484]
Cui X; Wang Y; Tang Y; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju S; Liu G; Yang H. 2011. Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet 20(15):3022-30. [PubMed: 21551454] [MGI Ref ID J:173404]
Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. [PubMed: 21602802] [MGI Ref ID J:172746]
Dakic A; Metcalf D; Di Rago L; Mifsud S; Wu L; Nutt SL. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201(9):1487-502. [PubMed: 15867096] [MGI Ref ID J:98188]
De Fazio S; Bartonicek N; Di Giacomo M; Abreu-Goodger C; Sankar A; Funaya C; Antony C; Moreira PN; Enright AJ; O'Carroll D. 2011. The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements. Nature 480(7376):259-63. [PubMed: 22020280] [MGI Ref ID J:184034]
Deng M; Pan L; Xie X; Gan L. 2010. Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol 338(1):38-49. [PubMed: 19913004] [MGI Ref ID J:156733]
Dong Y; Du X; Ye J; Han M; Xu T; Zhuang Y; Tao W. 2009. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol 183(6):3865-72. [PubMed: 19692642] [MGI Ref ID J:152323]
Dubielecka PM; Ladwein KI; Xiong X; Migeotte I; Chorzalska A; Anderson KV; Sawicki JA; Rottner K; Stradal TE; Kotula L. 2011. Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proc Natl Acad Sci U S A 108(17):7022-7. [PubMed: 21482783] [MGI Ref ID J:171342]
Dzhagalov I; St John A; He YW. 2007. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood 109(4):1620-6. [PubMed: 17062731] [MGI Ref ID J:137502]
Ecker JL; Dumitrescu ON; Wong KY; Alam NM; Chen SK; LeGates T; Renna JM; Prusky GT; Berson DM; Hattar S. 2010. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67(1):49-60. [PubMed: 20624591] [MGI Ref ID J:167871]
Emery B; Agalliu D; Cahoy JD; Watkins TA; Dugas JC; Mulinyawe SB; Ibrahim A; Ligon KL; Rowitch DH; Barres BA. 2009. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 138(1):172-85. [PubMed: 19596243] [MGI Ref ID J:150563]
Essalmani R; Zaid A; Marcinkiewicz J; Chamberland A; Pasquato A; Seidah NG; Prat A. 2008. In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A 105(15):5750-5. [PubMed: 18378898] [MGI Ref ID J:134264]
Fan X; Hou N; Fan K; Yuan J; Mo X; Deng Y; Wan Y; Teng Y; Yang X; Wu X. 2012. Geft is dispensable for the development of the second heart field. BMB Rep 45(3):153-8. [PubMed: 22449701] [MGI Ref ID J:183551]
Fan X; Liu X; Hao S; Wang B; Robinson ML; Monnier VM. 2012. The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One 7(11):e50832. [PubMed: 23226398] [MGI Ref ID J:194778]
Fan Y; Menon RK; Cohen P; Hwang D; Clemens T; DiGirolamo DJ; Kopchick JJ; Le Roith D; Trucco M; Sperling MA. 2009. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284(30):19937-44. [PubMed: 19460757] [MGI Ref ID J:152627]
Fan Y; Rudert WA; Grupillo M; He J; Sisino G; Trucco M. 2009. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28(18):2812-24. [PubMed: 19680229] [MGI Ref ID J:152798]
Farago AF; Awatramani RB; Dymecki SM. 2006. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron 50(2):205-18. [PubMed: 16630833] [MGI Ref ID J:133039]
Favaro R; Valotta M; Ferri AL; Latorre E; Mariani J; Giachino C; Lancini C; Tosetti V; Ottolenghi S; Taylor V; Nicolis SK. 2009. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10):1248-56. [PubMed: 19734891] [MGI Ref ID J:154650]
Feng JQ; Scott G; Guo D; Jiang B; Harris M; Ward T; Ray M; Bonewald LF; Harris SE; Mishina Y. 2008. Generation of a conditional null allele for Dmp1 in mouse. Genesis 46(2):87-91. [PubMed: 18257058] [MGI Ref ID J:135314]
Fernandez-Valdivia R; Jeong J; Mukherjee A; Soyal SM; Li J; Ying Y; Demayo FJ; Lydon JP. 2010. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis 48(2):106-13. [PubMed: 20029965] [MGI Ref ID J:158406]
Flodby P; Borok Z; Banfalvi A; Zhou B; Gao D; Minoo P; Ann DK; Morrisey EE; Crandall ED. 2010. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol 43(2):173-8. [PubMed: 19767448] [MGI Ref ID J:174124]
Foulkes T; Nassar MA; Lane T; Matthews EA; Baker MD; Gerke V; Okuse K; Dickenson AH; Wood JN. 2006. Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci 26(41):10499-507. [PubMed: 17035534] [MGI Ref ID J:113256]
Fragoso R; Mao T; Wang S; Schaffert S; Gong X; Yue S; Luong R; Min H; Yashiro-Ohtani Y; Davis M; Pear W; Chen CZ. 2012. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 8(8):e1002855. [PubMed: 22916024] [MGI Ref ID J:188125]
Gabel LA; Marin I; LoTurco JJ; Che A; Murphy C; Manglani M; Kass S. 2011. Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice. Genes Brain Behav 10(8):868-75. [PubMed: 21883923] [MGI Ref ID J:188826]
Gao X; Shin YH; Li M; Wang F; Tong Q; Zhang P. 2010. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 5(11):e14005. [PubMed: 21103374] [MGI Ref ID J:166984]
Gehman LT; Stoilov P; Maguire J; Damianov A; Lin CH; Shiue L; Ares M Jr; Mody I; Black DL. 2011. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43(7):706-11. [PubMed: 21623373] [MGI Ref ID J:176189]
Gladman JT; Bebee TW; Edwards C; Wang X; Sahenk Z; Rich MM; Chandler DS. 2010. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype. Hum Mol Genet 19(21):4239-52. [PubMed: 20705738] [MGI Ref ID J:164889]
Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G. 2006. Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-8. [PubMed: 16354690] [MGI Ref ID J:104114]
Gu P; Qi X; Zhou Y; Wang Y; Gao X. 2012. Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis 50(5):429-36. [PubMed: 21998041] [MGI Ref ID J:184036]
Gubbels Bupp MR; Edwards B; Guo C; Wei D; Chen G; Wong B; Masteller E; Peng SL. 2009. T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol 39(11):2991-2999. [PubMed: 19658095] [MGI Ref ID J:154205]
Hamada M; Haeger A; Jeganathan KB; van Ree JH; Malureanu L; Walde S; Joseph J; Kehlenbach RH; van Deursen JM. 2011. Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol 194(4):597-612. [PubMed: 21859863] [MGI Ref ID J:176959]
He F; Popkie AP; Xiong W; Li L; Wang Y; Phiel CJ; Chen Y. 2010. Gsk3beta is required in the epithelium for palatal elevation in mice. Dev Dyn 239(12):3235-46. [PubMed: 20981831] [MGI Ref ID J:166721]
He H; Mahnke AH; Doyle S; Fan N; Wang CC; Hall BJ; Tang YP; Inglis FM; Chen C; Erickson JD. 2012. Neurodevelopmental role for VGLUT2 in pyramidal neuron plasticity, dendritic refinement, and in spatial learning. J Neurosci 32(45):15886-901. [PubMed: 23136427] [MGI Ref ID J:192240]
Hertveldt V; Louryan S; van Reeth T; Dreze P; van Vooren P; Szpirer J; Szpirer C. 2008. The development of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn 237(4):883-92. [PubMed: 18297738] [MGI Ref ID J:132771]
Heyer MP; Pani AK; Smeyne RJ; Kenny PJ; Feng G. 2012. Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice. J Neurosci 32(32):10887-10894. [PubMed: 22875923] [MGI Ref ID J:186618]
Hippenmeyer S; Youn YH; Moon HM; Miyamichi K; Zong H; Wynshaw-Boris A; Luo L. 2010. Genetic mosaic dissection of lis1 and ndel1 in neuronal migration. Neuron 68(4):695-709. [PubMed: 21092859] [MGI Ref ID J:166047]
Hirata T; Li P; Lanuza GM; Cocas LA; Huntsman MM; Corbin JG. 2009. Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala. Nat Neurosci 12(2):141-9. [PubMed: 19136974] [MGI Ref ID J:146178]
Hnasko TS; Chuhma N; Zhang H; Goh GY; Sulzer D; Palmiter RD; Rayport S; Edwards RH. 2010. Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo. Neuron 65(5):643-56. [PubMed: 20223200] [MGI Ref ID J:167767]
Hoch RV; Soriano P. 2006. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133(4):663-73. [PubMed: 16421190] [MGI Ref ID J:105920]
Hockemeyer D; Daniels JP; Takai H; de Lange T. 2006. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126(1):63-77. [PubMed: 16839877] [MGI Ref ID J:112185]
Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. [PubMed: 17030618] [MGI Ref ID J:117666]
Hosoda A; Tokuda M; Akai R; Kohno K; Iwawaki T. 2010. Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland. Biochem J 425(1):117-25. [PubMed: 19788412] [MGI Ref ID J:159968]
Howard PW; Howard TL; Maurer RA. 2010. Generation of mice with a conditional allele for Ift172. Transgenic Res 19(1):121-6. [PubMed: 19521792] [MGI Ref ID J:156426]
Huang QQ; Hossain MM; Wu K; Parai K; Pope RM; Jin JP. 2008. Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem 283(38):25887-99. [PubMed: 18617524] [MGI Ref ID J:141867]
Huang Z; Rivas B; Agoulnik AI. 2012. Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice. Biol Reprod 87(6):143. [PubMed: 23100620] [MGI Ref ID J:194006]
Hurd EA; Poucher HK; Cheng K; Raphael Y; Martin DM. 2010. The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development 137(18):3139-50. [PubMed: 20736290] [MGI Ref ID J:164582]
Inagaki M; Komatsu Y; Scott G; Yamada G; Ray M; Ninomiya-Tsuji J; Mishina Y. 2008. Generation of a conditional mutant allele for Tab1 in mouse. Genesis 46(8):431-9. [PubMed: 18693278] [MGI Ref ID J:140317]
Ishiwata T; Orosz A; Wang X; Mustafi SB; Pratt GW; Christians ES; Boudina S; Abel ED; Benjamin IJ. 2012. HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. PLoS One 7(8):e42118. [PubMed: 22870288] [MGI Ref ID J:189659]
Iwawaki T; Akai R; Yamanaka S; Kohno K. 2009. Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A 106(39):16657-62. [PubMed: 19805353] [MGI Ref ID J:153222]
Jackson CR; Ruan GX; Aseem F; Abey J; Gamble K; Stanwood G; Palmiter RD; Iuvone PM; McMahon DG. 2012. Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci 32(27):9359-9368. [PubMed: 22764243] [MGI Ref ID J:185955]
Jaworski A; Smith CL; Burden SJ. 2007. GA-Binding Protein Is Dispensable for Neuromuscular Synapse Formation and Synapse-Specific Gene Expression. Mol Cell Biol 27(13):5040-6. [PubMed: 17485447] [MGI Ref ID J:121823]
Jeon Y; Ko E; Lee KY; Ko MJ; Park SY; Kang J; Jeon CH; Lee H; Hwang DS. 2011. TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem 286(7):5414-22. [PubMed: 21149450] [MGI Ref ID J:170406]
Jia W; He YW. 2011. Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol 186(9):5313-22. [PubMed: 21421856] [MGI Ref ID J:172749]
Jia Y; Viswakarma N; Crawford SE; Sarkar J; Sambasiva Rao M; Karpus WJ; Kanwar YS; Zhu YJ; Reddy JK. 2012. Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. Mech Dev 129(9-12):193-207. [PubMed: 22982455] [MGI Ref ID J:189008]
Jiang R; Wang S; Takahashi K; Fujita H; Fruci CR; Breyer MD; Harris RC; Takahashi T. 2012. Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis 50(9):685-92. [PubMed: 22467476] [MGI Ref ID J:187860]
Jiang Z; Zhu L; Hu L; Slesnick TC; Pautler RG; Justice MJ; Belmont JW. 2013. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet 22(5):879-89. [PubMed: 23184148] [MGI Ref ID J:192577]
Jin YR; Turcotte TJ; Crocker AL; Han XH; Yoon JK. 2011. The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol 352(1):1-13. [PubMed: 21237142] [MGI Ref ID J:171482]
Jonassen JA; San Agustin J; Follit JA; Pazour GJ. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-84. [PubMed: 18981227] [MGI Ref ID J:141071]
Jonassen JA; Sanagustin J; Baker SP; Pazour GJ. 2012. Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation. J Am Soc Nephrol :. [PubMed: 22282595] [MGI Ref ID J:181533]
Kallies A; Xin A; Belz GT; Nutt SL. 2009. Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity 31(2):283-95. [PubMed: 19664942] [MGI Ref ID J:151858]
Katzel D; Zemelman BV; Buetfering C; Wolfel M; Miesenbock G. 2011. The columnar and laminar organization of inhibitory connections to neocortical excitatory cells. Nat Neurosci 14(1):100-7. [PubMed: 21076426] [MGI Ref ID J:194305]
Kim D; Lee J; Cheng D; Li J; Carter C; Richie E; Bedford MT. 2010. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem 285(2):1147-52. [PubMed: 19897492] [MGI Ref ID J:159958]
Kim IJ; Zhang Y; Meister M; Sanes JR. 2010. Laminar restriction of retinal ganglion cell dendrites and axons: subtype-specific developmental patterns revealed with transgenic markers. J Neurosci 30(4):1452-62. [PubMed: 20107072] [MGI Ref ID J:157687]
Kim IJ; Zhang Y; Yamagata M; Meister M; Sanes JR. 2008. Molecular identification of a retinal cell type that responds to upward motion. Nature 452(7186):478-82. [PubMed: 18368118] [MGI Ref ID J:134167]
Kim IS; Lee M; Park KC; Jeon Y; Park JH; Hwang EJ; Jeon TI; Ko S; Lee H; Baek SH; Kim KI. 2012. Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell 46(3):260-73. [PubMed: 22516971] [MGI Ref ID J:188023]
Klein U; Casola S; Cattoretti G; Shen Q; Lia M; Mo T; Ludwig T; Rajewsky K; Dalla-Favera R. 2006. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol 7(7):773-82. [PubMed: 16767092] [MGI Ref ID J:112643]
Klein U; Lia M; Crespo M; Siegel R; Shen Q; Mo T; Ambesi-Impiombato A; Califano A; Migliazza A; Bhagat G; Dalla-Favera R. 2010. The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell 17(1):28-40. [PubMed: 20060366] [MGI Ref ID J:156946]
Kong D; Vong L; Parton LE; Ye C; Tong Q; Hu X; Choi B; Bruning JC; Lowell BB. 2010. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab 12(5):545-52. [PubMed: 21035764] [MGI Ref ID J:167906]
Kopinke D; Brailsford M; Shea JE; Leavitt R; Scaife CL; Murtaugh LC. 2011. Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 138(3):431-41. [PubMed: 21205788] [MGI Ref ID J:169830]
Kopinke D; Murtaugh LC. 2010. Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol 10:38. [PubMed: 20377894] [MGI Ref ID J:159445]
Kruse SE; Watt WC; Marcinek DJ; Kapur RP; Schenkman KA; Palmiter RD. 2008. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Cell Metab 7(4):312-20. [PubMed: 18396137] [MGI Ref ID J:134334]
Kurosaka S; Leu NA; Zhang F; Bunte R; Saha S; Wang J; Guo C; He W; Kashina A. 2010. Arginylation-dependent neural crest cell migration is essential for mouse development. PLoS Genet 6(3):e1000878. [PubMed: 20300656] [MGI Ref ID J:159224]
Lai JC; Ponti S; Pan D; Kohler H; Skoda RC; Matthias P; Nagamine Y. 2012. The DEAH-box helicase RHAU is an essential gene and critical for mouse hematopoiesis. Blood 119(18):4291-300. [PubMed: 22422825] [MGI Ref ID J:185179]
Lan Y; Liu H; Ovitt CE; Jiang R. 2011. Generation of Osr1 conditional mutant mice. Genesis 49(5):419-22. [PubMed: 21462293] [MGI Ref ID J:172133]
Lan Y; Wang Q; Ovitt CE; Jiang R. 2007. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis 45(10):618-24. [PubMed: 17941042] [MGI Ref ID J:128736]
Leavens KF; Easton RM; Shulman GI; Previs SF; Birnbaum MJ. 2009. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab 10(5):405-18. [PubMed: 19883618] [MGI Ref ID J:155432]
Lee S; Lee JW; Lee SK. 2012. UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program. Dev Cell 22(1):25-37. [PubMed: 22192413] [MGI Ref ID J:180125]
Lee YK; Schmidt DR; Cummins CL; Choi M; Peng L; Zhang Y; Goodwin B; Hammer RE; Mangelsdorf DJ; Kliewer SA. 2008. Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol 22(6):1345-56. [PubMed: 18323469] [MGI Ref ID J:135822]
Lehre AC; Rowley NM; Zhou Y; Holmseth S; Guo C; Holen T; Hua R; Laake P; Olofsson AM; Poblete-Naredo I; Rusakov DA; Madsen KK; Clausen RP; Schousboe A; White HS; Danbolt NC. 2011. Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res 95(1-2):70-81. [PubMed: 21459558] [MGI Ref ID J:180428]
Leu NA; Kurosaka S; Kashina A. 2009. Conditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in mice. PLoS One 4(11):e7734. [PubMed: 19890395] [MGI Ref ID J:155427]
Levitt PS; Liu H; Manning C; Weiss RS. 2005. Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics 86(2):212-24. [PubMed: 15919177] [MGI Ref ID J:99339]
Li H; Cho SN; Evans CM; Dickey BF; Jeong JW; DeMayo FJ. 2008. Cre-mediated recombination in mouse Clara cells. Genesis 46(6):300-7. [PubMed: 18543320] [MGI Ref ID J:136676]
Li J; Yu M; Feng G; Hu H; Li X. 2011. Breaches of the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies. Neurosci Lett 505(1):19-24. [PubMed: 21970971] [MGI Ref ID J:178536]
Li P; Li M; Lindberg MR; Kennett MJ; Xiong N; Wang Y. 2010. PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med 207(9):1853-62. [PubMed: 20733033] [MGI Ref ID J:165718]
Li Z; Li Y; Chakraborty M; Fan Y; Bui HH; Peake DA; Kuo MS; Xiao X; Cao G; Jiang XC. 2009. Liver-specific deficiency of serine palmitoyltransferase subunit 2 decreases plasma sphingomyelin and increases apolipoprotein E levels. J Biol Chem 284(39):27010-9. [PubMed: 19648608] [MGI Ref ID J:155507]
Lia M; Carette A; Tang H; Shen Q; Mo T; Bhagat G; Dalla-Favera R; Klein U. 2011. Functional dissection of the chromosome 13q14 tumor suppressor locus using transgenic mouse lines. Blood :. [PubMed: 22174151] [MGI Ref ID J:179879]
Lin Y; Liu G; Wang F. 2006. Generation of an Fgf9 conditional null allele. Genesis 44(3):150-4. [PubMed: 16496342] [MGI Ref ID J:106766]
Lin Y; Zhang J; Zhang Y; Wang F. 2007. Generation of an Frs2alpha conditional null allele. Genesis 45(9):554-9. [PubMed: 17868091] [MGI Ref ID J:128712]
Liu W; Selever J; Lu MF; Martin JF. 2003. Genetic dissection of Pitx2 in craniofacial development uncovers new functions in branchial arch morphogenesis, late aspects of tooth morphogenesis and cell migration. Development 130(25):6375-85. [PubMed: 14623826] [MGI Ref ID J:87220]
Liu W; Shaver TM; Balasa A; Ljungberg MC; Wang X; Wen S; Nguyen H; Van den Veyver IB. 2012. Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One 7(3):e32331. [PubMed: 22412863] [MGI Ref ID J:186934]
Liu X; Yan X; Zhong B; Nurieva RI; Wang A; Wang X; Martin-Orozco N; Wang Y; Chang SH; Esplugues E; Flavell RA; Tian Q; Dong C. 2012. Bcl6 expression specifies the T follicular helper cell program in vivo. J Exp Med 209(10):1841-52, S1-24. [PubMed: 22987803] [MGI Ref ID J:191271]
Liu Z; Liao L; Zhou S; Xu J. 2008. Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci 4(4):202-7. [PubMed: 18690289] [MGI Ref ID J:161101]
Lu LF; Gavin MA; Rasmussen JP; Rudensky AY. 2007. G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol 27(23):8065-72. [PubMed: 17893329] [MGI Ref ID J:127791]
Lu S; Lu LY; Liu MF; Yuan QJ; Sham MH; Guan XY; Huang JD. 2012. Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood. Neurobiol Dis 45(1):219-33. [PubMed: 21871565] [MGI Ref ID J:179845]
Lu Z; Jiang YP; Wang W; Xu XH; Mathias RT; Entcheva E; Ballou LM; Cohen IS; Lin RZ. 2009. Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation 120(4):318-25. [PubMed: 19597047] [MGI Ref ID J:166421]
Ma XM; Kiraly DD; Gaier ED; Wang Y; Kim EJ; Levine ES; Eipper BA; Mains RE. 2008. Kalirin-7 is required for synaptic structure and function. J Neurosci 28(47):12368-82. [PubMed: 19020030] [MGI Ref ID J:142364]
Maag D; Maxwell MJ; Hardesty DA; Boucher KL; Choudhari N; Hanno AG; Ma JF; Snowman AS; Pietropaoli JW; Xu R; Storm PB; Saiardi A; Snyder SH; Resnick AC. 2011. Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB. Proc Natl Acad Sci U S A 108(4):1391-6. [PubMed: 21220345] [MGI Ref ID J:168243]
Malfait AM; Ritchie J; Gil AS; Austin JS; Hartke J; Qin W; Tortorella MD; Mogil JS. 2010. ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage 18(4):572-80. [PubMed: 20036347] [MGI Ref ID J:175366]
Mao CA; Kiyama T; Pan P; Furuta Y; Hadjantonakis AK; Klein WH. 2008. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development 135(2):271-80. [PubMed: 18077589] [MGI Ref ID J:130570]
Mao CA; Tsai WW; Cho JH; Pan P; Barton MC; Klein WH. 2011. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol 349(1):90-9. [PubMed: 20969844] [MGI Ref ID J:167071]
Mao Y; Mulvaney J; Zakaria S; Yu T; Morgan KM; Allen S; Basson MA; Francis-West P; Irvine KD. 2011. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development 138(5):947-57. [PubMed: 21303848] [MGI Ref ID J:169135]
Mar L; Yang FC; Ma Q. 2012. Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system. Mol Brain 5:3. [PubMed: 22272772] [MGI Ref ID J:180805]
Martin-Millan M; Almeida M; Ambrogini E; Han L; Zhao H; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2010. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 24(2):323-34. [PubMed: 20053716] [MGI Ref ID J:156947]
Matkovich SJ; Diwan A; Klanke JL; Hammer DJ; Marreez Y; Odley AM; Brunskill EW; Koch WJ; Schwartz RJ; Dorn GW 2nd. 2006. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res 99(9):996-1003. [PubMed: 17008600] [MGI Ref ID J:126501]
McCright B; Lozier J; Gridley T. 2006. Generation of new Notch2 mutant alleles. Genesis 44(1):29-33. [PubMed: 16397869] [MGI Ref ID J:105278]
Moghaddam SJ; Li H; Cho SN; Dishop MK; Wistuba II; Ji L; Kurie JM; Dickey BF; Demayo FJ. 2009. Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol 40(4):443-53. [PubMed: 18927348] [MGI Ref ID J:159271]
Morikawa Y; D'Autreaux F; Gershon MD; Cserjesi P. 2007. Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol 307(1):114-26. [PubMed: 17531968] [MGI Ref ID J:122604]
Mu X; Fu X; Beremand PD; Thomas TL; Klein WH. 2008. Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A 105(19):6942-7. [PubMed: 18460603] [MGI Ref ID J:146349]
Mukhopadhyay A; Jarrett J; Chlon T; Kessler JA. 2009. HeyL regulates the number of TrkC neurons in dorsal root ganglia. Dev Biol 334(1):142-51. [PubMed: 19631204] [MGI Ref ID J:153555]
Murchison ND; Price BA; Conner DA; Keene DR; Olson EN; Tabin CJ; Schweitzer R. 2007. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 134(14):2697-708. [PubMed: 17567668] [MGI Ref ID J:122742]
Murphy MM; Lawson JA; Mathew SJ; Hutcheson DA; Kardon G. 2011. Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development 138(17):3625-37. [PubMed: 21828091] [MGI Ref ID J:174914]
Murray SA; Carver EA; Gridley T. 2006. Generation of a Snail1 (Snai1) conditional null allele. Genesis 44(1):7-11. [PubMed: 16397867] [MGI Ref ID J:105294]
Nakagawa S; Naganuma T; Shioi G; Hirose T. 2011. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol 193(1):31-9. [PubMed: 21444682] [MGI Ref ID J:171281]
Nakamura T; Nakagawa M; Ichisaka T; Shiota A; Yamanaka S. 2011. Essential roles of ECAT15-2/Dppa2 in functional lung development. Mol Cell Biol 31(21):4366-78. [PubMed: 21896782] [MGI Ref ID J:178324]
Nassar MA; Stirling LC; Forlani G; Baker MD; Matthews EA; Dickenson AH; Wood JN. 2004. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A 101(34):12706-11. [PubMed: 15314237] [MGI Ref ID J:92442]
Nijnik A; Clare S; Hale C; Chen J; Raisen C; Mottram L; Lucas M; Estabel J; Ryder E; Adissu H; Adams NC; Ramirez-Solis R; White JK; Steel KP; Dougan G; Hancock RE. 2012. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol 189(1):102-11. [PubMed: 22664872] [MGI Ref ID J:188933]
Novarino G; Weinert S; Rickheit G; Jentsch TJ. 2010. Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science 328(5984):1398-401. [PubMed: 20430975] [MGI Ref ID J:160701]
Nukaya M; Lin BC; Glover E; Moran SM; Kennedy GD; Bradfield CA. 2010. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 285(46):35599-605. [PubMed: 20829355] [MGI Ref ID J:166864]
Nukaya M; Moran S; Bradfield CA. 2009. The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A 106(12):4923-8. [PubMed: 19261855] [MGI Ref ID J:147150]
O'Carroll D; Mecklenbrauker I; Das PP; Santana A; Koenig U; Enright AJ; Miska EA; Tarakhovsky A. 2007. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev 21(16):1999-2004. [PubMed: 17626790] [MGI Ref ID J:165967]
Olsen O; Funke L; Long JF; Fukata M; Kazuta T; Trinidad JC; Moore KA; Misawa H; Welling PA; Burlingame AL; Zhang M; Bredt DS. 2007. Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. J Cell Biol 179(1):151-64. [PubMed: 17923534] [MGI Ref ID J:134806]
Olson DP; Pulinilkunnil T; Cline GW; Shulman GI; Lowell BB. 2010. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A 107(16):7598-603. [PubMed: 20368432] [MGI Ref ID J:159285]
Ozkaynak E; Abello G; Jaegle M; van Berge L; Hamer D; Kegel L; Driegen S; Sagane K; Bermingham JR Jr; Meijer D. 2010. Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. J Neurosci 30(10):3857-64. [PubMed: 20220021] [MGI Ref ID J:158973]
Pan L; Deng M; Xie X; Gan L. 2008. ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development 135(11):1981-90. [PubMed: 18434421] [MGI Ref ID J:134978]
Paul E; Cronan R; Weston PJ; Boekelheide K; Sedivy JM; Lee SY; Wiest DL; Resnick MB; Klysik JE. 2009. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Mamm Genome 20(2):92-108. [PubMed: 19145458] [MGI Ref ID J:144991]
Peng C; Ye J; Yan S; Kong S; Shen Y; Li C; Li Q; Zheng Y; Deng K; Xu T; Tao W. 2012. Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem :. [PubMed: 22854957] [MGI Ref ID J:186307]
Peng WT; Pan CJ; Lee EJ; Westphal H; Chou JY. 2009. Generation of mice with a conditional allele for G6pc. Genesis 47(9):590-4. [PubMed: 19548314] [MGI Ref ID J:155990]
Peng YJ; He WQ; Tang J; Tao T; Chen C; Gao YQ; Zhang WC; He XY; Dai YY; Zhu NC; Lv N; Zhang CH; Qiao YN; Zhao LP; Gao X; Zhu MS. 2010. Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem 285(32):24834-44. [PubMed: 20516067] [MGI Ref ID J:165902]
Prosser HM; Rzadzinska AK; Steel KP; Bradley A. 2008. Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol 28(5):1702-12. [PubMed: 18160714] [MGI Ref ID J:132633]
Qu X; Pan Y; Carbe C; Powers A; Grobe K; Zhang X. 2012. Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development 139(15):2730-9. [PubMed: 22745308] [MGI Ref ID J:185652]
Quintana A; Sanz E; Wang W; Storey GP; Guler AD; Wanat MJ; Roller BA; La Torre A; Amieux PS; McKnight GS; Bamford NS; Palmiter RD. 2012. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat Neurosci 15(11):1547-55. [PubMed: 23064379] [MGI Ref ID J:193543]
Rasmussen KD; Simmini S; Abreu-Goodger C; Bartonicek N; Di Giacomo M; Bilbao-Cortes D; Horos R; Von Lindern M; Enright AJ; O'Carroll D. 2010. The miR-144/451 locus is required for erythroid homeostasis. J Exp Med 207(7):1351-8. [PubMed: 20513743] [MGI Ref ID J:163418]
Rawlins EL; Clark CP; Xue Y; Hogan BL. 2009. The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development 136(22):3741-5. [PubMed: 19855016] [MGI Ref ID J:154450]
Rawlins EL; Okubo T; Xue Y; Brass DM; Auten RL; Hasegawa H; Wang F; Hogan BL. 2009. The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium. Cell Stem Cell 4(6):525-34. [PubMed: 19497281] [MGI Ref ID J:149822]
Raymond CS; Soriano P. 2010. ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo. Genesis 48(10):603-6. [PubMed: 20665730] [MGI Ref ID J:170010]
Recher M; Burns SO; de la Fuente MA; Volpi S; Dahlberg C; Walter JE; Moffitt K; Mathew D; Honke N; Lang PA; Patrizi L; Falet H; Keszei M; Mizui M; Csizmadia E; Candotti F; Nadeau K; Bouma G; Delmonte OM; Frugoni F; Fomin AB; Buchbinder D; Lundequist EM; Massaad MJ; Tsokos GC; Hartwig J; Manis J; Terhorst C; Geha RS; Snapper S; Lang KS; Malley R; Westerberg L; Thrasher AJ; Notarangelo LD. 2012. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood 119(12):2819-28. [PubMed: 22302739] [MGI Ref ID J:182528]
Reuter M; Berninger P; Chuma S; Shah H; Hosokawa M; Funaya C; Antony C; Sachidanandam R; Pillai RS. 2011. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature 480(7376):264-7. [PubMed: 22121019] [MGI Ref ID J:182800]
Ricke RM; Jeganathan KB; Malureanu L; Harrison AM; van Deursen JM. 2012. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol 199(6):931-49. [PubMed: 23209306] [MGI Ref ID J:195237]
Rickheit G; Wartosch L; Schaffer S; Stobrawa SM; Novarino G; Weinert S; Jentsch TJ. 2010. Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. J Biol Chem 285(23):17595-603. [PubMed: 20351103] [MGI Ref ID J:164474]
Rongvaux A; Galli M; Denanglaire S; Van Gool F; Dreze PL; Szpirer C; Bureau F; Andris F; Leo O. 2008. Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J Immunol 181(7):4685-95. [PubMed: 18802071] [MGI Ref ID J:141448]
Rose MF; Ahmad KA; Thaller C; Zoghbi HY. 2009. Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A 106(52):22462-7. [PubMed: 20080794] [MGI Ref ID J:155932]
Rose MF; Ren J; Ahmad KA; Chao HT; Klisch TJ; Flora A; Greer JJ; Zoghbi HY. 2009. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron 64(3):341-54. [PubMed: 19914183] [MGI Ref ID J:155760]
Rowan S; Cepko CL. 2004. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 271(2):388-402. [PubMed: 15223342] [MGI Ref ID J:91498]
Ruediger R; Ruiz J; Walter G. 2011. Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol 31(18):3832-44. [PubMed: 21791616] [MGI Ref ID J:175748]
Sandell LL; Lynn ML; Inman KE; McDowell W; Trainor PA. 2012. RDH10 oxidation of Vitamin A is a critical control step in synthesis of retinoic acid during mouse embryogenesis. PLoS One 7(2):e30698. [PubMed: 22319578] [MGI Ref ID J:185330]
Schmahl J; Rizzolo K; Soriano P. 2008. The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev 22(23):3255-67. [PubMed: 19056881] [MGI Ref ID J:142042]
Sivakamasundari V; Chan HY; Yap SP; Xing X; Kraus P; Lufkin T. 2011. New Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout studies. Genesis :. [PubMed: 21913311] [MGI Ref ID J:178893]
Skidmore JM; Cramer JD; Martin JF; Martin DM. 2008. Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus. Mol Cell Neurosci 37(4):696-707. [PubMed: 18206388] [MGI Ref ID J:135239]
Sousa VH; Miyoshi G; Hjerling-Leffler J; Karayannis T; Fishell G. 2009. Characterization of Nkx6-2-derived neocortical interneuron lineages. Cereb Cortex 19 Suppl 1:i1-10. [PubMed: 19363146] [MGI Ref ID J:155164]
Stephan AB; Tobochnik S; Dibattista M; Wall CM; Reisert J; Zhao H. 2012. The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci 15(1):131-7. [PubMed: 22057188] [MGI Ref ID J:180325]
Stubbusch J; Majdazari A; Schmidt M; Schutz G; Deller T; Rohrer H. 2011. Generation of the tamoxifen-inducible DBH-Cre transgenic mouse line DBH-CT. Genesis 49(12):935-41. [PubMed: 21634003] [MGI Ref ID J:180731]
Suire S; Lecureuil C; Anderson KE; Damoulakis G; Niewczas I; Davidson K; Guillou H; Pan D; Clark J; Hawkins PT; Stephens L. 2012. GPCR activation of Ras and PI3Kgamma in neutrophils depends on PLCbeta2/beta3 and the RasGEF RasGRP4. EMBO J :. [PubMed: 22728827] [MGI Ref ID J:186412]
Sylva M; Li VS; Buffing AA; van Es JH; van den Born M; van der Velden S; Gunst Q; Koolstra JH; Moorman AF; Clevers H; van den Hoff MJ. 2011. The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One 6(8):e22616. [PubMed: 21826198] [MGI Ref ID J:176532]
Szabova L; Son MY; Shi J; Sramko M; Yamada SS; Swaim WD; Zerfas P; Kahan S; Holmbeck K. 2010. Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood 116(25):5752-61. [PubMed: 20858856] [MGI Ref ID J:167396]
Tabaries S; Lemieux M; Aubin J; Jeannotte L. 2007. Comparative analysis of Hoxa5 allelic series. Genesis 45(4):218-28. [PubMed: 17417799] [MGI Ref ID J:125040]
Tanaka KF; Ahmari SE; Leonardo ED; Richardson-Jones JW; Budreck EC; Scheiffele P; Sugio S; Inamura N; Ikenaka K; Hen R. 2010. Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry 67(8):770-3. [PubMed: 20163789] [MGI Ref ID J:159353]
Tanaka KF; Matsui K; Sasaki T; Sano H; Sugio S; Fan K; Hen R; Nakai J; Yanagawa Y; Hasuwa H; Okabe M; Deisseroth K; Ikenaka K; Yamanaka A. 2012. Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Rep 2(2):397-406. [PubMed: 22854021] [MGI Ref ID J:186771]
Tang MC; Jacobs SA; Wong LH; Mann JR. 2013. Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse. Genesis 51(2):142-6. [PubMed: 23315948] [MGI Ref ID J:194069]
Tang W; Zeve D; Suh JM; Bosnakovski D; Kyba M; Hammer RE; Tallquist MD; Graff JM. 2008. White fat progenitor cells reside in the adipose vasculature. Science 322(5901):583-6. [PubMed: 18801968] [MGI Ref ID J:178521]
Thompson D; Martini L; Whistler JL. 2010. Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One 5(6):e11038. [PubMed: 20543951] [MGI Ref ID J:161807]
Tong Q; Ye C; McCrimmon RJ; Dhillon H; Choi B; Kramer MD; Yu J; Yang Z; Christiansen LM; Lee CE; Choi CS; Zigman JM; Shulman GI; Sherwin RS; Elmquist JK; Lowell BB. 2007. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5(5):383-93. [PubMed: 17488640] [MGI Ref ID J:129860]
Tong Q; Ye CP; Jones JE; Elmquist JK; Lowell BB. 2008. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci :. [PubMed: 18690230] [MGI Ref ID J:140858]
Tsuboi K; Okamoto Y; Ikematsu N; Inoue M; Shimizu Y; Uyama T; Wang J; Deutsch DG; Burns MP; Ulloa NM; Tokumura A; Ueda N. 2011. Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochim Biophys Acta 1811(10):565-77. [PubMed: 21801852] [MGI Ref ID J:177598]
Urness LD; Paxton CN; Wang X; Schoenwolf GC; Mansour SL. 2010. FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol 340(2):595-604. [PubMed: 20171206] [MGI Ref ID J:160254]
Voehringer D; Wu D; Liang HE; Locksley RM. 2009. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol 9:69. [PubMed: 19638212] [MGI Ref ID J:157129]
Waite MR; Skaggs K; Kaviany P; Skidmore JM; Causeret F; Martin JF; Martin DM. 2012. Distinct populations of GABAergic neurons in mouse rhombomere 1 express but do not require the homeodomain transcription factor PITX2. Mol Cell Neurosci 49(1):32-43. [PubMed: 21925604] [MGI Ref ID J:189488]
Waite MR; Skidmore JM; Billi AC; Martin JF; Martin DM. 2011. GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons. Dev Dyn 240(2):333-46. [PubMed: 21246650] [MGI Ref ID J:167837]
Wang C; Lee JE; Cho YW; Xiao Y; Jin Q; Liu C; Ge K. 2012. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A 109(38):15324-9. [PubMed: 22949634] [MGI Ref ID J:190157]
Wang P; Bowl MR; Bender S; Peng J; Farber L; Chen J; Ali A; Zhang Z; Alberts AS; Thakker RV; Shilatifard A; Williams BO; Teh BT. 2008. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol 28(9):2930-40. [PubMed: 18212049] [MGI Ref ID J:135255]
Wang X; Li Y; Zhang X; Goodrich DW. 2007. An allelic series for studying the mouse Thoc1 gene. Genesis 45(1):32-7. [PubMed: 17211872] [MGI Ref ID J:117869]
Wang Y; Yin X; Rosen G; Gabel L; Guadiana SM; Sarkisian MR; Galaburda AM; Loturco JJ. 2011. Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience 190:398-408. [PubMed: 21689730] [MGI Ref ID J:175635]
Wei J; Shi Y; Zheng L; Zhou B; Inose H; Wang J; Guo XE; Grosschedl R; Karsenty G. 2012. miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol 197(4):509-21. [PubMed: 22564414] [MGI Ref ID J:185130]
Wei W; Yang Z; Tang CH; Liu L. 2011. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32(7):973-7. [PubMed: 21385828] [MGI Ref ID J:173666]
Weinert S; Jabs S; Supanchart C; Schweizer M; Gimber N; Richter M; Rademann J; Stauber T; Kornak U; Jentsch TJ. 2010. Lysosomal Pathology and Osteopetrosis upon Loss of H+-Driven Lysosomal Cl- Accumulation. Science :. [PubMed: 20430974] [MGI Ref ID J:160702]
Weissgerber P; Kriebs U; Tsvilovskyy V; Olausson J; Kretz O; Stoerger C; Mannebach S; Wissenbach U; Vennekens R; Middendorff R; Flockerzi V; Freichel M. 2012. Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. J Biol Chem 287(22):17930-41. [PubMed: 22427671] [MGI Ref ID J:185629]
Weissgerber P; Kriebs U; Tsvilovskyy V; Olausson J; Kretz O; Stoerger C; Vennekens R; Wissenbach U; Middendorff R; Flockerzi V; Freichel M. 2011. Male fertility depends on Ca(2)+ absorption by TRPV6 in epididymal epithelia. Sci Signal 4(171):ra27. [PubMed: 21540454] [MGI Ref ID J:185996]
White TA; Johnson T; Zarzhevsky N; Tom C; Delacroix S; Holroyd EW; Maroney SA; Singh R; Pan S; Fay WP; van Deursen J; Mast AE; Sandhu GS; Simari RD. 2010. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood 116(10):1787-94. [PubMed: 20516367] [MGI Ref ID J:164530]
Wilson CH; Crombie C; van der Weyden L; Poulogiannis G; Rust AG; Pardo M; Gracia T; Yu L; Choudhary J; Poulin GB; McIntyre RE; Winton DJ; March HN; Arends MJ; Fraser AG; Adams DJ. 2012. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. EMBO J 31(11):2486-97. [PubMed: 22510880] [MGI Ref ID J:184685]
Wilson CL; Gough PJ; Chang CA; Chan CK; Frey JM; Liu Y; Braun KR; Chin MT; Wight TN; Raines EW. 2013. Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev 130(4-5):272-89. [PubMed: 23354118] [MGI Ref ID J:195050]
Wit N; Krijger PH; van den Berk PC; Jacobs H. 2011. Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA. PLoS One 6(1):e16669. [PubMed: 21304913] [MGI Ref ID J:169551]
Wolfler A; Danen-van Oorschot AA; Haanstra JR; Valkhof M; Bodner C; Vroegindeweij E; van Strien P; Novak A; Cupedo T; Touw IP. 2010. Lineage-instructive function of C/EBPalpha in multipotent hematopoietic cells and early thymic progenitors. Blood 116(20):4116-25. [PubMed: 20807890] [MGI Ref ID J:166620]
Xia A; Gao SS; Yuan T; Osborn A; Bress A; Pfister M; Maricich SM; Pereira FA; Oghalai JS. 2010. Deficient forward transduction and enhanced reverse transduction in the alpha tectorin C1509G human hearing loss mutation. Dis Model Mech 3(3-4):209-23. [PubMed: 20142329] [MGI Ref ID J:160851]
Xia J; Varudkar N; Baker CN; Abukenda I; Martinez C; Natarajan A; Grinberg A; Pfeifer K; Ebert SN. 2012. Targeting of the Enhanced Green Fluorescent Protein Reporter to Adrenergic Cells in Mice. Mol Biotechnol :. [PubMed: 22706789] [MGI Ref ID J:190425]
Xie R; Jiang R; Chen D. 2011. Generation of Axin1 conditional mutant mice. Genesis 49(2):98-102. [PubMed: 21344612] [MGI Ref ID J:169694]
Xiong J; Onal M; Jilka RL; Weinstein RS; Manolagas SC; O'Brien CA. 2011. Matrix-embedded cells control osteoclast formation. Nat Med 17(10):1235-41. [PubMed: 21909103] [MGI Ref ID J:177558]
Xu J; Krebs LT; Gridley T. 2010. Generation of mice with a conditional null allele of the Jagged2 gene. Genesis 48(6):390-3. [PubMed: 20533406] [MGI Ref ID J:163652]
Xu K; Nieuwenhuis E; Cohen BL; Wang W; Canty AJ; Danska JS; Coultas L; Rossant J; Wu MY; Piscione TD; Nagy A; Gossler A; Hicks GG; Hui CC; Henkelman RM; Yu LX; Sled JG; Gridley T; Egan SE. 2010. Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol 298(1):L45-56. [PubMed: 19897741] [MGI Ref ID J:155893]
Yamamoto M; Shook NA; Kanisicak O; Yamamoto S; Wosczyna MN; Camp JR; Goldhamer DJ. 2009. A multifunctional reporter mouse line for Cre- and FLP-dependent lineage analysis. Genesis 47(2):107-14. [PubMed: 19165827] [MGI Ref ID J:147304]
Yap SP; Xing X; Kraus P; Sivakamasundari V; Chan HY; Lufkin T. 2011. Generation of mice with a novel conditional null allele of the Sox9 gene. Biotechnol Lett 33(8):1551-8. [PubMed: 21484342] [MGI Ref ID J:176950]
Yokoi F; Dang MT; Mitsui S; Li J; Li Y. 2008. Motor Deficits and Hyperactivity in Cerebral Cortex-specific Dyt1 Conditional Knockout Mice. J Biochem 143(1):39-47. [PubMed: 17956903] [MGI Ref ID J:130483]
Yokoi F; Dang MT; Mitsui S; Li Y. 2005. Exclusive paternal expression and novel alternatively spliced variants of epsilon-sarcoglycan mRNA in mouse brain. FEBS Lett 579(21):4822-8. [PubMed: 16099459] [MGI Ref ID J:101332]
Yokoi F; Dang MT; Yang G; Li J; Doroodchi A; Zhou T; Li Y. 2012. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models. Behav Brain Res 227(1):12-20. [PubMed: 22040906] [MGI Ref ID J:180682]
Yoshioka J; Imahashi K; Gabel SA; Chutkow WA; Burds AA; Gannon J; Schulze PC; MacGillivray C; London RE; Murphy E; Lee RT. 2007. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res 101(12):1328-38. [PubMed: 17916779] [MGI Ref ID J:141487]
Zaid A; Roubtsova A; Essalmani R; Marcinkiewicz J; Chamberland A; Hamelin J; Tremblay M; Jacques H; Jin W; Davignon J; Seidah NG; Prat A. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 48(2):646-54. [PubMed: 18666258] [MGI Ref ID J:169834]
Zeng H. 2011. Direct Data Submission 2011/10/17 MGI Direct Data Submission :. [MGI Ref ID J:176570]
Zeng H; Hoover AN; Liu A. 2010. PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals. Dev Biol 339(2):418-28. [PubMed: 20067783] [MGI Ref ID J:159120]
Zhang J; Kelley KL; Marshall SM; Davis MA; Wilson MD; Sawyer JK; Farese RV Jr; Brown JM; Rudel LL. 2012. Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood. J Lipid Res 53(6):1144-52. [PubMed: 22460046] [MGI Ref ID J:184908]
Zhang L; Zhou F; Han W; Shen B; Luo J; Shibuya M; He Y. 2010. VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res 20(12):1319-31. [PubMed: 20697430] [MGI Ref ID J:177405]
Zhang N; He YW. 2005. An essential role for c-FLIP in the efficient development of mature T lymphocytes. J Exp Med 202(3):395-404. [PubMed: 16043517] [MGI Ref ID J:100558]
Zhang N; He YW. 2005. The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol 174(11):6967-73. [PubMed: 15905539] [MGI Ref ID J:99012]
Zhang Y; Singh MK; Degenhardt KR; Lu MM; Bennett J; Yoshida Y; Epstein JA. 2009. Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol 325(1):82-93. [PubMed: 18992737] [MGI Ref ID J:143763]
Zhao J; Nassar MA; Gavazzi I; Wood JN. 2006. Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis 44(8):364-71. [PubMed: 16850455] [MGI Ref ID J:114488]
Zhao T; Zhou X; Szabo N; Leitges M; Alvarez-Bolado G. 2007. Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord. Genesis 45(12):781-7. [PubMed: 18064677] [MGI Ref ID J:130491]
Zhong Z; Baker JJ; Zylstra-Diegel CR; Williams BO. 2012. Lrp5 and Lrp6 play compensatory roles in mouse intestinal development. J Cell Biochem 113(1):31-8. [PubMed: 21866564] [MGI Ref ID J:179033]
Zhou J; Gao Y; Zhang Z; Zhang Y; Maltby KM; Liu Z; Lan Y; Jiang R. 2011. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol 353(2):344-53. [PubMed: 21420399] [MGI Ref ID J:173121]
Zhou X; Xiang Y; Garrard WT. 2010. The Igkappa gene enhancers, E3' and Ed, are essential for triggering transcription. J Immunol 185(12):7544-52. [PubMed: 21076060] [MGI Ref ID J:167472]
Zhou Y; Holmseth S; Guo C; Hassel B; Hofner G; Huitfeldt HS; Wanner KT; Danbolt NC. 2012. Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem 287(42):35733-46. [PubMed: 22896705] [MGI Ref ID J:191581]
Zhu L; Gibson P; Currle DS; Tong Y; Richardson RJ; Bayazitov IT; Poppleton H; Zakharenko S; Ellison DW; Gilbertson RJ. 2009. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457(7229):603-7. [PubMed: 19092805] [MGI Ref ID J:144215]
Zhu L; Peng JL; Harutyunyan KG; Garcia MD; Justice MJ; Belmont JW. 2007. Craniofacial, skeletal, and cardiac defects associated with altered embryonic murine Zic3 expression following targeted insertion of a PGK-NEO cassette. Front Biosci 12:1680-90. [PubMed: 17127413] [MGI Ref ID J:117748]
Zouvelou V; Passa O; Segklia K; Tsalavos S; Valenzuela DM; Economides AN; Graf D. 2009. Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol 53(4):597-603. [PubMed: 19247966] [MGI Ref ID J:149134]
de Wit T; Dekker S; Maas A; Breedveld G; Knoch TA; Langeveld A; Szumska D; Craig R; Bhattacharya S; Grosveld F; Drabek D. 2010. Tagged mutagenesis by efficient Minos-based germ line transposition. Mol Cell Biol 30(1):68-77. [PubMed: 19884347] [MGI Ref ID J:156413]
van der Weyden L; Giotopoulos G; Rust AG; Matheson LS; van Delft FW; Kong J; Corcoran AE; Greaves MF; Mullighan CG; Huntly BJ; Adams DJ. 2011. Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice. Blood 118(4):1041-51. [PubMed: 21628403] [MGI Ref ID J:174866]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred together. Mating System Homozygote x Homozygote (Female x Male) 26-APR-10 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $177.00 Female or Male Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym
Price per Pair (US dollars $) Pair Genotype $354.00 Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym x Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $230.10 Female or Male Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym
Price per Pair (US dollars $) Pair Genotype $460.20 Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym x Homozygous for Gt(ROSA)26Sortm1(FLP1)Dym Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.