Strain Name:

B6.129P2(SJL)-Myd88tm1.1Defr/J

Stock Number:

009088

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Myd88 KO mice have hematopoietic system defects, as well as signaling and apoptotic defects. They have increased susceptibility to bacterial and viral infection due to immune system abnormalities.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   26-OCT-10
Specieslaboratory mouse
GenerationN10+N3 F2 (27-OCT-10)
Generation Definitions
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Important Note
The Myd88-deficient allele encodes a deletion of exon 3 of the myeloid differentiation primary response gene 88 locus. Myd88-deficiency is associated with a number of immune system abnormalities, as well as hematopoietic system and apoptotic abnormalities.

Description
Homozygous mice are viable and fertile. The Myd88-deficient allele encodes a deletion of exon 3 of the myeloid differentiation primary response gene 88 gene. MYD88 is a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. MyD88 signaling is required to limit bacterial burden and prolong survival during infection. Myd88-deficiency is associated with a number of immune system abnormalities, as well as hematopoietic system, molecular signaling, and apoptotic abnormalities. These mice have increased susceptibility to bacterial and viral infection and should be maintained in a specific pathogen free environment.

Development
Myd88fl mice, harboring loxP sites on either side of exon 3 of the Myd88 gene, arrived at The Jackson Laboratory congenic on the C57BL/6J genetic background (see Stock No. 008888). Upon arrival, some of these Myd88fl mice were bred with C57BL/6-Tg(Zp3-Cre)93Knw/J mice (Stock No. 003651) for germline removal of loxP-flanked exon 3. Offspring with the floxed exon 3 removed were identified and then selectively bred to C57BL/6J inbred mice to remove the Cre transgene. The resulting mice, heterozygous for the Myd88-deficient allele, were subsequently bred together, to wildtype siblings, or to C57BL/6J inbred mice to establish this strain (as Stock No. 009088).

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Myd88
008888   B6.129P2(SJL)-Myd88tm1Defr/J
016133   C57BL/6-Tg(Defa2-Myd88)1Lvh/J
017481   C57BL/6-Tg(Vil1-Myd88)1Lvh/J
009108   CBy.129P2(B6)-Myd88tm1Defr/J
012622   NOD.Cg-Myd88tm1Defr/J
View Strains carrying other alleles of Myd88     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Macroglobulinemia, Waldenstrom, Susceptibility to, 1; WM1   (MYD88)
Myd88 Deficiency; MYD88D   (MYD88)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Myd88tm1.1Defr/Myd88+

        involves: 129P2/OlaHsd * C57BL/6
  • no phenotypic analysis
  • *normal* no phenotypic analysis   (MGI Ref ID J:139001)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Apoptosis Research
Endogenous Regulators

Cancer Research
Genes Regulating Growth and Proliferation
Growth Factors/Receptors/Cytokines

Cell Biology Research
Genes Regulating Growth and Proliferation
Signal Transduction
Transcriptional Regulation

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Intracellular Signaling Molecules

Research Tools
Apoptosis Research
Cancer Research
Cell Biology Research
Immunology, Inflammation and Autoimmunity Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Myd88tm1.1Defr
Allele Name targeted mutation 1.1, Anthony L DeFranco
Allele Type Targeted (Null/Knockout)
Mutation Made By Anthony DeFranco,   UCSF
Strain of Origin129P2/OlaHsd
Gene Symbol and Name Myd88, myeloid differentiation primary response gene 88
Chromosome 9
Gene Common Name(s) MYD88D;
Molecular Note Mice carrying the Myd88tm1Defr allele were crossed with Tg(Zp3-cre)93Knw mice to remove exon 3. [MGI Ref ID J:139001]

Genotyping

Genotyping Information

Genotyping Protocols

Myd88tm1.1Defr, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Hou B; Reizis B; Defranco AL. 2008. Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms. Immunity 29(2):272-82. [PubMed: 18656388]  [MGI Ref ID J:139001]

Additional References

Myd88tm1.1Defr related

Aachoui Y; Leaf IA; Hagar JA; Fontana MF; Campos CG; Zak DE; Tan MH; Cotter PA; Vance RE; Aderem A; Miao EA. 2013. Caspase-11 protects against bacteria that escape the vacuole. Science 339(6122):975-8. [PubMed: 23348507]  [MGI Ref ID J:193387]

Ali OA; Verbeke C; Johnson C; Sands RW; Lewin SA; White D; Doherty E; Dranoff G; Mooney DJ. 2014. Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants. Cancer Res 74(6):1670-81. [PubMed: 24480625]  [MGI Ref ID J:208326]

Arjunaraja S; Massari P; Wetzler LM; Lees A; Colino J; Snapper CM. 2012. The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain. J Immunol 188(2):569-77. [PubMed: 22156342]  [MGI Ref ID J:180885]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

Bates JT; Graff AH; Phipps JP; Grayson JM; Mizel SB. 2011. Enhanced Antigen Processing of Flagellin Fusion Proteins Promotes the Antigen-Specific CD8+ T Cell Response Independently of TLR5 and MyD88. J Immunol 186(11):6255-62. [PubMed: 21515787]  [MGI Ref ID J:173205]

Beauchamp NM; Yammani RD; Alexander-Miller MA. 2012. CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. J Virol 86(19):10640-50. [PubMed: 22811544]  [MGI Ref ID J:187891]

Bosmann M; Patel VR; Russkamp NF; Pache F; Zetoune FS; Sarma JV; Ward PA. 2011. MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FASEB J 25(12):4222-32. [PubMed: 21859896]  [MGI Ref ID J:178398]

Bosmann M; Strobl B; Kichler N; Rigler D; Grailer JJ; Pache F; Murray PJ; Muller M; Ward PA. 2014. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96(1):123-31. [PubMed: 24604832]  [MGI Ref ID J:212012]

Brandt EB; Gibson AM; Bass S; Rydyznski C; Khurana Hershey GK. 2013. Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice. J Immunol 191(7):3519-25. [PubMed: 23997219]  [MGI Ref ID J:205950]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. [PubMed: 23965627]  [MGI Ref ID J:205431]

Crespo MI; Zacca ER; Nunez NG; Ranocchia RP; Maccioni M; Maletto BA; Pistoresi-Palencia MC; Moron G. 2013. TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface. J Immunol 190(3):948-60. [PubMed: 23284054]  [MGI Ref ID J:193025]

Ding N; Zhang Y; Loughran PA; Wang Q; Tsung A; Billiar TR. 2013. TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release. Free Radic Biol Med 63:361-7. [PubMed: 23722163]  [MGI Ref ID J:205170]

Fernandez I; Harlow L; Zang Y; Liu-Bryan R; Ridgway WM; Clemens PR; Ascherman DP. 2013. Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis. J Immunol 191(4):1865-72. [PubMed: 23842751]  [MGI Ref ID J:205700]

Frazer LC; Sullivan JE; Zurenski MA; Mintus M; Tomasak TE; Prantner D; Nagarajan UM; Darville T. 2013. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol 191(8):4269-79. [PubMed: 24038087]  [MGI Ref ID J:206277]

Fukuzawa N; Petro M; Baldwin WM 3rd; Gudkov AV; Fairchild RL. 2011. A TLR5 agonist inhibits acute renal ischemic failure. J Immunol 187(7):3831-9. [PubMed: 21890657]  [MGI Ref ID J:179325]

Hakim F; Wang Y; Zhang SX; Zheng J; Yolcu ES; Carreras A; Khalyfa A; Shirwan H; Almendros I; Gozal D. 2014. Fragmented sleep accelerates tumor growth and progression through recruitment of tumor-associated macrophages and TLR4 signaling. Cancer Res 74(5):1329-37. [PubMed: 24448240]  [MGI Ref ID J:208152]

Huang Y; Aydintug MK; Loomis J; Macleod MK; McKee AS; Kirchenbaum G; Jakubzick CV; Kedl RM; Sun D; Jacobelli J; O'Brien RL; Born WK. 2013. Antigen-specific regulation of IgE antibodies by non-antigen-specific gammadelta T cells. J Immunol 190(3):913-21. [PubMed: 23275606]  [MGI Ref ID J:193031]

Huber S; Gagliani N; Zenewicz LA; Huber FJ; Bosurgi L; Hu B; Hedl M; Zhang W; O'Connor W Jr; Murphy AJ; Valenzuela DM; Yancopoulos GD; Booth CJ; Cho JH; Ouyang W; Abraham C; Flavell RA. 2012. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491(7423):259-63. [PubMed: 23075849]  [MGI Ref ID J:189217]

Hung CY; Jimenez-Alzate Mdel P; Gonzalez A; Wuthrich M; Klein BS; Cole GT. 2014. Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection. Infect Immun 82(5):2106-14. [PubMed: 24614655]  [MGI Ref ID J:210238]

Jiang G; Sun D; Yang H; Lu Q; Kaplan HJ; Shao H. 2014. HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells. J Leukoc Biol 95(4):599-607. [PubMed: 24374967]  [MGI Ref ID J:211961]

Kawamoto N; Ohnishi H; Kondo N; Strominger JL. 2013. The role of dendritic cells in the generation of CD4(+) CD25(HI) Foxp3(+) T cells induced by amino acid copolymers. Int Immunol 25(1):53-65. [PubMed: 22968996]  [MGI Ref ID J:197126]

Kim K; Sohn H; Kim JS; Choi HG; Byun EH; Lee KI; Shin SJ; Song CH; Park JK; Kim HJ. 2012. Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway. Immunology 136(2):231-40. [PubMed: 22385341]  [MGI Ref ID J:185378]

Ko MK; Saraswathy S; Parikh JG; Rao NA. 2011. The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest Ophthalmol Vis Sci 52(8):5824-35. [PubMed: 21666244]  [MGI Ref ID J:181405]

Kole A; He J; Rivollier A; Silveira DD; Kitamura K; Maloy KJ; Kelsall BL. 2013. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis. J Immunol 191(5):2771-9. [PubMed: 23913971]  [MGI Ref ID J:205804]

Kotas ME; Jurczak MJ; Annicelli C; Gillum MP; Cline GW; Shulman GI; Medzhitov R. 2013. Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A 110(12):4810-5. [PubMed: 23487794]  [MGI Ref ID J:194242]

Lebel ME; Daudelin JF; Chartrand K; Tarrab E; Kalinke U; Savard P; Labrecque N; Leclerc D; Lamarre A. 2014. Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection. J Immunol 192(3):1071-8. [PubMed: 24376264]  [MGI Ref ID J:207307]

Lim H; Kim YU; Sun H; Lee JH; Reynolds JM; Hanabuchi S; Wu H; Teng BB; Chung Y. 2014. Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity 40(1):153-65. [PubMed: 24412615]  [MGI Ref ID J:209392]

Mohamadzadeh M; Pfeiler EA; Brown JB; Zadeh M; Gramarossa M; Managlia E; Bere P; Sarraj B; Khan MW; Pakanati KC; Ansari MJ; O'Flaherty S; Barrett T; Klaenhammer TR. 2011. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A 108 Suppl 1:4623-30. [PubMed: 21282652]  [MGI Ref ID J:170355]

Mortha A; Chudnovskiy A; Hashimoto D; Bogunovic M; Spencer SP; Belkaid Y; Merad M. 2014. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 343(6178):1249288. [PubMed: 24625929]  [MGI Ref ID J:209599]

Mulay SR; Kulkarni OP; Rupanagudi KV; Migliorini A; Darisipudi MN; Vilaysane A; Muruve D; Shi Y; Munro F; Liapis H; Anders HJ. 2013. Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1beta secretion. J Clin Invest 123(1):236-46. [PubMed: 23221343]  [MGI Ref ID J:194155]

Nagareddy PR; Kraakman M; Masters SL; Stirzaker RA; Gorman DJ; Grant RW; Dragoljevic D; Hong ES; Abdel-Latif A; Smyth SS; Choi SH; Korner J; Bornfeldt KE; Fisher EA; Dixit VD; Tall AR; Goldberg IJ; Murphy AJ. 2014. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab 19(5):821-35. [PubMed: 24807222]  [MGI Ref ID J:215261]

Nagareddy PR; Murphy AJ; Stirzaker RA; Hu Y; Yu S; Miller RG; Ramkhelawon B; Distel E; Westerterp M; Huang LS; Schmidt AM; Orchard TJ; Fisher EA; Tall AR; Goldberg IJ. 2013. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab 17(5):695-708. [PubMed: 23663738]  [MGI Ref ID J:199272]

Neighbours LM; Long K; Whitmore AC; Heise MT. 2012. Myd88-dependent toll-like receptor 7 signaling mediates protection from severe ross river virus-induced disease in mice. J Virol 86(19):10675-85. [PubMed: 22837203]  [MGI Ref ID J:187888]

Panigrahi S; Ma Y; Hong L; Gao D; West XZ; Salomon RG; Byzova TV; Podrez EA. 2013. Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis. Circ Res 112(1):103-12. [PubMed: 23071157]  [MGI Ref ID J:212876]

Park CK; Xu ZZ; Berta T; Han Q; Chen G; Liu XJ; Ji RR. 2014. Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron 82(1):47-54. [PubMed: 24698267]  [MGI Ref ID J:213160]

Park K; Scott AL. 2010. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol 88(6):1081-7. [PubMed: 20699362]  [MGI Ref ID J:166647]

Park SR; Kim DJ; Han SH; Kang MJ; Lee JY; Jeong YJ; Lee SJ; Kim TH; Ahn SG; Yoon JH; Park JH. 2014. Diverse Toll-like receptors mediate cytokine production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages. Infect Immun 82(5):1914-20. [PubMed: 24566622]  [MGI Ref ID J:209890]

Reardon C; Duncan GS; Brustle A; Brenner D; Tusche MW; Olofsson P; Rosas-Ballina M; Tracey KJ; Mak TW. 2013. Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A 110(4):1410-5. [PubMed: 23297238]  [MGI Ref ID J:193708]

Rowley SM; Kuriakose T; Dockery LM; Tran-Ngyuen T; Gingerich AD; Wei L; Watford WT. 2014. Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation. J Biol Chem 289(22):15788-97. [PubMed: 24713702]  [MGI Ref ID J:214118]

Russo BC; Brown MJ; Nau GJ. 2013. MyD88-Dependent Signaling Prolongs Survival and Reduces Bacterial Burden during Pulmonary Infection with Virulent Francisella tularensis. Am J Pathol 183(4):1223-32. [PubMed: 23920326]  [MGI Ref ID J:200915]

Ruud J; Wilhelms DB; Nilsson A; Eskilsson A; Tang YJ; Strohle P; Caesar R; Schwaninger M; Wunderlich T; Backhed F; Engblom D; Blomqvist A. 2013. Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells. FASEB J 27(5):1973-80. [PubMed: 23395911]  [MGI Ref ID J:197842]

Schuettpelz LG; Borgerding JN; Christopher MJ; Gopalan PK; Romine MP; Herman AC; Woloszynek JR; Greenbaum AM; Link DC. 2014. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia 28(9):1851-60. [PubMed: 24518205]  [MGI Ref ID J:213449]

Watts BA 3rd; George T; Good DW. 2013. Lumen LPS inhibits HCOFormula absorption in the medullary thick ascending limb through TLR4-PI3K-Akt-mTOR-dependent inhibition of basolateral Na+/H+ exchange. Am J Physiol Renal Physiol 305(4):F451-62. [PubMed: 23698118]  [MGI Ref ID J:200847]

Watts BA 3rd; George T; Sherwood ER; Good DW. 2011. Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb. Am J Physiol Cell Physiol 301(6):C1296-306. [PubMed: 21881005]  [MGI Ref ID J:178333]

Wolf AJ; Arruda A; Reyes CN; Kaplan AT; Shimada T; Shimada K; Arditi M; Liu G; Underhill DM. 2011. Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria. J Immunol 187(11):6002-10. [PubMed: 22031762]  [MGI Ref ID J:179760]

Xu X; Zhang H; Song Y; Lynch SV; Lowell CA; Wiener-Kronish JP; Caughey GH. 2012. Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa. J Leukoc Biol 91(2):275-84. [PubMed: 22075928]  [MGI Ref ID J:181039]

Xue X; Feng T; Yao S; Wolf KJ; Liu CG; Liu X; Elson CO; Cong Y. 2011. Microbiota downregulates dendritic cell expression of miR-10a, which targets IL-12/IL-23p40. J Immunol 187(11):5879-86. [PubMed: 22068236]  [MGI Ref ID J:179678]

Yazji I; Sodhi CP; Lee EK; Good M; Egan CE; Afrazi A; Neal MD; Jia H; Lin J; Ma C; Branca MF; Prindle T; Richardson WM; Ozolek J; Billiar TR; Binion DG; Gladwin MT; Hackam DJ. 2013. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A 110(23):9451-6. [PubMed: 23650378]  [MGI Ref ID J:197450]

Yoshida H; Russell J; Senchenkova EY; Almeida Paula LD; Granger DN. 2010. Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis. Am J Pathol 177(6):2774-81. [PubMed: 20971730]  [MGI Ref ID J:170780]

da Silva HB; de Salles EM; Panatieri RH; Boscardin SB; Rodriguez-Malaga SM; Alvarez JM; D'Imperio Lima MR. 2013. IFN-gamma-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria. J Immunol 191(10):5160-9. [PubMed: 24133169]  [MGI Ref ID J:206324]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together. These mice have increased susceptibility to bacterial and viral infection and should be maintained in a specific pathogen free environment.
Mating SystemHomozygote x Homozygote         (Female x Male)   26-OCT-10
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Myd88tm1.1Defr  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Myd88tm1.1Defr x Homozygous for Myd88tm1.1Defr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Myd88tm1.1Defr  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Myd88tm1.1Defr x Homozygous for Myd88tm1.1Defr  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

The Myd88-deficient allele encodes a deletion of exon 3 of the myeloid differentiation primary response gene 88 locus. Myd88-deficiency is associated with a number of immune system abnormalities, as well as hematopoietic system and apoptotic abnormalities.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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For Licensing and Use Restrictions view the link(s) below:
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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