Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Inbred x Inbred         (Female x Male)   09-APR-09 Species laboratory mouse H2 Haplotype g7 Generation F38+F7 (29-JUN-11) Generation Definitions   Donating Investigator Rosemary W. Elliott,   Roswell Park Cancer Inst.

Appearance
albino
Related Genotype: A/A, Tyr^c/Tyr^c

Description
This inbred strain is derived from the outbred stock ICR. ICR/HaJ may serve as a general purpose strain and is known for susceptibility to induced colon cancer. In contrast to resistant C57BL/6HaJ (009123), 100% of ICR/HaJ mice develop colon tumors and adenocarcinomas by 24 weeks following subcutaneous injection of 1,2-dimethylhydrazine (DMH). ICR/HaJ carries the MHC haplotype H2^g7 and may be used as a control for NOD/ShiLtJ (Stock #001976). Mice do not develop insulitis or diabetes. Like ICR, this inbred is highly prolific. This strain may be useful in therapeutic drug testing, genetic analysis of carcinogen-induced colon cancer and as control for NOD/ShiLtJ.

Development
This inbred strain was developed from the HA(ICR) outbred stock brought to the Roswell Park Cancer Institute by Dr. Hauschka in 1954. HA(ICR) originated from a Swiss Webster stock purchased from J. C. Landis in 1947 and was maintained by Dr. Hauschka at the Institute for Cancer Research in Philadelphia. HA(ICR) was selected for reproductive vigor (fecundity) and is one of the most prolific of the outbred strains. ICR/Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.

Related Strains

Strains carrying other alleles of Ccs1

009123

C57BL/6HaJ

View Strains carrying other alleles of Ccs1     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: ICR

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Other Tissues/Organs
      Other Tissues/Organs: GI tract (stomach, intestine, colon)

Research Tools
General Purpose

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Ccs1ICR/Ha
Allele Name		ICR/Ha
Allele Type		QTL
Strain of Origin		ICR/Ha
Gene Symbol and Name		Ccs1, colon cancer susceptibility 1
Chromosome		12
Molecular Note		This allele confers susceptibility to colon tumors compared to C57BL/6Ha. [MGI Ref ID J:19675]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Evans JT; Shows TB; Sproul EE; Paolini NS; Mittelman A; Hauschka TS. 1977. Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Cancer Res 37(1):134-6. [PubMed: 830402]  [MGI Ref ID J:5732]

Jacoby RF; Hohman C; Marshall DJ; Frick TJ; Schlack S; Broda M; Smutko J; Elliott RW. 1994. Genetic analysis of colon cancer susceptibility in mice. Genomics 22(2):381-7. [PubMed: 7806225]  [MGI Ref ID J:19675]

Additional References

Hauschka TS; Mirand EA. 1973. The 'Breeder: HA(ICR)' Swiss mouse, a multipurpose stock selected for fecundity. In: Perspectives in Cancer Research and Treatment. Alan R. Liss, Inc., New York.  [MGI Ref ID J:26298]

Lipkin SM; Wang V; Jacoby R; Banerjee-Basu S; Baxevanis AD; Lynch HT; Elliott RM; Collins FS. 2000. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability Nat Genet 24(1):27-35. [PubMed: 10615123]  [MGI Ref ID J:59324]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & Husbandry	ICR/HaJ mice are susceptible to eye inflammation, therefore nestlets are not recommended as bedding material.
Mating System	Inbred x Inbred         (Female x Male)   09-APR-09
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

Terms of Use

General Terms and Conditions

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