Strain Name:

ICR/HaJ

Stock Number:

009122

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Common Names: ICR;    
This inbred strain is derived from the outbred strain ICR. It may be useful in therapeutic drug testing and genetic analysis of carcinogen-induced colon cancer.

Description

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemInbred x Inbred         (Female x Male)   09-APR-09
Specieslaboratory mouse
H2 Haplotypeg7
GenerationF38+F15 (11-DEC-13)
Generation Definitions
 
Donating Investigator Rosemary W. Elliott,   Roswell Park Cancer Inst.

Appearance
albino
Related Genotype: A/A, Tyrc/Tyrc

Description
This inbred strain is derived from the outbred stock ICR. ICR/HaJ may serve as a general purpose strain and is known for susceptibility to induced colon cancer. In contrast to resistant C57BL/6HaJ (009123), 100% of ICR/HaJ mice develop colon tumors and adenocarcinomas by 24 weeks following subcutaneous injection of 1,2-dimethylhydrazine (DMH). ICR/HaJ carries the MHC haplotype H2g7 and may be used as a control for NOD/ShiLtJ (Stock #001976). Mice do not develop insulitis or diabetes. Like ICR, this inbred is highly prolific. This strain may be useful in therapeutic drug testing, genetic analysis of carcinogen-induced colon cancer and as control for NOD/ShiLtJ.

Development
This inbred strain was developed from the HA(ICR) outbred stock brought to the Roswell Park Cancer Institute by Dr. Hauschka in 1954. HA(ICR) originated from a Swiss Webster stock purchased from J. C. Landis in 1947 and was maintained by Dr. Hauschka at the Institute for Cancer Research in Philadelphia. HA(ICR) was selected for reproductive vigor (fecundity) and is one of the most prolific of the outbred strains. ICR/Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.

Related Strains

Strains carrying other alleles of Ccs1
009123   C57BL/6HaJ
View Strains carrying other alleles of Ccs1     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Other Tissues/Organs
      Other Tissues/Organs: GI tract (stomach, intestine, colon)

Research Tools
General Purpose

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ccs1ICR/Ha
Allele Name ICR/Ha
Allele Type QTL
Strain of OriginICR/Ha
Gene Symbol and Name Ccs1, colon cancer susceptibility 1
Chromosome 12
Molecular Note This allele confers susceptibility to colon tumors compared to C57BL/6Ha. [MGI Ref ID J:19675]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Evans JT; Shows TB; Sproul EE; Paolini NS; Mittelman A; Hauschka TS. 1977. Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Cancer Res 37(1):134-6. [PubMed: 830402]  [MGI Ref ID J:5732]

Jacoby RF; Hohman C; Marshall DJ; Frick TJ; Schlack S; Broda M; Smutko J; Elliott RW. 1994. Genetic analysis of colon cancer susceptibility in mice. Genomics 22(2):381-7. [PubMed: 7806225]  [MGI Ref ID J:19675]

Additional References

Hauschka TS; Mirand EA. 1973. The 'Breeder: HA(ICR)' Swiss mouse, a multipurpose stock selected for fecundity. In: Perspectives in Cancer Research and Treatment. Alan R. Liss, Inc., New York.  [MGI Ref ID J:26298]

Lipkin SM; Wang V; Jacoby R; Banerjee-Basu S; Baxevanis AD; Lynch HT; Elliott RM; Collins FS. 2000. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability Nat Genet 24(1):27-35. [PubMed: 10615123]  [MGI Ref ID J:59324]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryICR/HaJ mice are susceptible to eye inflammation, therefore nestlets are not recommended as bedding material.
Mating SystemInbred x Inbred         (Female x Male)   09-APR-09
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $72.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $93.60Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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