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| This inbred strain is a substrain of C57BL/6. This strain may be useful as a general purpose strain or as a model of resistance in carcinogen-induced colon cancer. | |||||||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Inbred x Inbred (Female x Male) 20-DEC-11 Species laboratory mouse Generation F?+F9 (29-JUN-11)
Generation DefinitionsAppearance
black
Related Genotype: a/aDescription
This inbred strain is a substrain of C57BL/6. C57BL/6HaJ may serve as a general purpose strain, in addition, it is known for resistance to induced colon cancer. In contrast to 100% susceptible ICR/HaJ (009122) mice, no tumors develop in C57BL/6HaJ mice following subcutaneous injection of 1,2-dimethylhydrazine (DMH) during a 44 week observation period. Other substrains, C57BL/6J (000664 ) and C57BL/6N, exhibit a lesser degree of resistance, 43% and 85% respectively. This strain may be useful in genetic analysis of carcinogen-induced colon cancer.Development
This substrain of the inbred strain C57BL originated in the laboratory of Dr. Hauschka at Roswell Park Cancer Institute. C57BL/6Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
Related Strains
C57BL Strains
000665 C57BL/10J 003752 C57BL/10ScNJ 000476 C57BL/10ScSnJ 000666 C57BL/10SnJ 001822 C57BL/10SxJ 001197 C57BL/10WtRkJ 000663 C57BL/6By 001139 C57BL/6ByJ 000664 C57BL/6J 000924 C57BL/6JEiJ 005304 C57BL/6NJ View C57BL Strains (11 strains)
009122 ICR/HaJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Research Tools
General Purpose
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Ccs1C57BL/6Ha | ||
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| Allele Name | C57BL/6Ha | ||
| Allele Type | QTL | ||
| Strain of Origin | C57BL/6Ha | ||
| Gene Symbol and Name | Ccs1, colon cancer susceptibility 1 | ||
| Chromosome | 12 | ||
| Molecular Note | This allele confers resistance to colon tumors compared to ICR/Ha. [MGI Ref ID J:19675] | ||
References
References provided by MGI
Selected Reference(s)
Diwan BA; Blackman KE. 1980. Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine. Cancer Lett 9(2):111-5. [PubMed: 7379041] [MGI Ref ID J:146512]
Evans JT; Shows TB; Sproul EE; Paolini NS; Mittelman A; Hauschka TS. 1977. Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Cancer Res 37(1):134-6. [PubMed: 830402] [MGI Ref ID J:5732]
Jacoby RF; Hohman C; Marshall DJ; Frick TJ; Schlack S; Broda M; Smutko J; Elliott RW. 1994. Genetic analysis of colon cancer susceptibility in mice. Genomics 22(2):381-7. [PubMed: 7806225] [MGI Ref ID J:19675]
Additional References
Lipkin SM; Wang V; Jacoby R; Banerjee-Basu S; Baxevanis AD; Lynch HT; Elliott RM; Collins FS. 2000. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability Nat Genet 24(1):27-35. [PubMed: 10615123] [MGI Ref ID J:59324]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry C57BL/6HaJ mice are susceptible to malocclusion and hydrocephalus. Mating System Inbred x Inbred (Female x Male) 20-DEC-11 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Individual Mouse $99.00 Female or Male Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Individual Mouse $128.70 Female or Male Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
Contact information
General inquiriesContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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