Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Inbred x Inbred         (Female x Male)   09-APR-09 Species laboratory mouse Generation F?+1 (18-AUG-09)

Appearance
black
Related Genotype: a/a

Description
This inbred strain is a substrain of C57BL/6. C57BL/6HaJ may serve as a general purpose strain, in addition, it is known for resistance to induced colon cancer. In contrast to 100% susceptible ICR/HaJ (009122) mice, no tumors develop in C57BL/6HaJ mice following subcutaneous injection of 1,2-dimethylhydrazine (DMH) during a 44 week observation period. Other substrains, C57BL/6J (000664 ) and C57BL/6N, exhibit a lesser degree of resistance, 43% and 85% respectively. This strain may be useful in genetic analysis of carcinogen-induced colon cancer.

Development
This substrain of the inbred strain C57BL originated in the laboratory of Dr. Hauschka at Roswell Park Cancer Institute. C57BL/6Ha has been maintained by sibling matings at Roswell Park for more than 30 years. Dr. Rosemary Elliott donated this strain to the Repository in 2009.

Control Information

	Control
	None Available
Considerations for Choosing Controls

Related Strains

C57BL Strains

000665	C57BL/10J
003752	C57BL/10ScNJ
000476	C57BL/10ScSnJ
000666	C57BL/10SnJ
001822	C57BL/10SxJ
001197	C57BL/10WtRkJ
000663	C57BL/6By
001139	C57BL/6ByJ
000664	C57BL/6J
000924	C57BL/6JEiJ
005304	C57BL/6NJ

View C57BL Strains     (11 strains)

Strains carrying other alleles of Ccs1

009122

ICR/HaJ

View Strains carrying other alleles of Ccs1     (1 strain)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
General Purpose

Genes & Alleles

Gene & Allele Information

Allele Symbol		Ccs1C57BL/6Ha
Allele Name		C57BL/6Ha
Allele Type		QTL
Strain of Origin		C57BL/6Ha
Gene Symbol and Name		Ccs1, colon cancer susceptibility 1
Chromosome		12
Molecular Note		This allele confers resistance to colon tumors compared to ICR/Ha. [MGI Ref ID J:19675]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Diwan BA; Blackman KE. 1980. Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine. Cancer Lett 9(2):111-5. [PubMed: 7379041]  [MGI Ref ID J:146512]

Evans JT; Shows TB; Sproul EE; Paolini NS; Mittelman A; Hauschka TS. 1977. Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. Cancer Res 37(1):134-6. [PubMed: 830402]  [MGI Ref ID J:5732]

Jacoby RF; Hohman C; Marshall DJ; Frick TJ; Schlack S; Broda M; Smutko J; Elliott RW. 1994. Genetic analysis of colon cancer susceptibility in mice. Genomics 22(2):381-7. [PubMed: 7806225]  [MGI Ref ID J:19675]

Additional References

Lipkin SM; Wang V; Jacoby R; Banerjee-Basu S; Baxevanis AD; Lynch HT; Elliott RM; Collins FS. 2000. MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability Nat Genet 24(1):27-35. [PubMed: 10615123]  [MGI Ref ID J:59324]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & Husbandry	C57BL/6HaJ mice are susceptible to malocclusion and hydrocephalus.
Mating System	Inbred x Inbred         (Female x Male)   09-APR-09
Diet Information	LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.

Supply Notes

Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection.

Control Information

	Control
	None Available
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

Contact information

General inquiries

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phone:	207-288-6470
fax:	207-288-6655

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