Strain Name:

B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/Mmjax


Cryopreserved - Ready for recovery     Available at the JAX MMRRC

Use Restrictions Apply, see Terms of Use
Common Names: iNOS-; Tg-SwDI;     APPSwDI/NOS2 bigenic mice;     APPSwDI/NOS2-/-;    
Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for ordering information and strain details on B6.Cg-Nos2 Tg(Thy1-APPSwDutIowa)BWevn/Mmjax MMRRC Stock Number 034849.
As a designated MMRRC center, The Jackson Laboratory will continue to distribute these mice at the same high health and
quality standards but ordering is exclusively provided through the MMRRC.
These APPSwDI/NOS2 bigenic mice (formerly JAX Stock No. 009126) harbor the APPSwDI transgene and a targeted "null" mutation of the nitric oxide synthase 2 (Nos2) locus. Homozygous bigenic mice (APPSwDI/NOS2-/-) progress from Aβ production and amyloid deposition to hyperphosphorylated normal mouse tau at Alzheimer's disease-associated epitopes, aggregation and redistribution of tau to somatodendritic regions of neurons, significant neuronal loss (including loss of interneurons), moderate-severe cerebral amyloid angiopathy, and severe learning and memory deficits. This Alzheimer's disease-like pathology is also accompanied by robust behavioral changes. These APPSwDI/NOS2 bigenic mice may be useful in studying Alzheimer's disease progression and the role of nitric oxide in altering chronic neurological disease processes.


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.Cg-Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/J    (Changed: 11-AUG-11 )
Type Congenic; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Generation Definitions
Donating Investigator IMR Colony,   The Jackson Laboratory

These APPSwDI/NOS2 bigenic mice harbor the APPSwDI transgene and a targeted "null" mutation of the nitric oxide synthase 2 (Nos2) locus. Expression of the APPSwDI transgene (a neuronally derived human amyloid beta-precursor protein [APP or AβPP] 770 isoform containing three Alzheimer's disease-associated mutations [Swedish K670N/M671L, Dutch E693Q and Iowa D694N] all under the control of the mouse thymus cell antigen 1, theta [Thy1] promoter) produces amyloid-beta (Aβ) peptides that cannot be transported out of the brain across the cerebrovascular interface and results in Aβ peptide accumulation at the blood vessels (see C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax). The Nos2 mutation results in loss of inducible NOS (iNOS) expression which alters physiological functions related to disease and injury (see B6.129P2-Nos2tm1Lau/J). Homozygous bigenic mice (APPSwDI/NOS2-/-) progress from Abeta; production and amyloid deposition to hyperphosphorylated normal mouse tau at Alzheimer's disease-associated epitopes, aggregation and redistribution of tau to somatodendritic regions of neurons, significant neuronal loss (including loss of interneurons), moderate-severe cerebral amyloid angiopathy, and severe learning and memory deficits. This Alzheimer's disease-like pathology is also accompanied by robust behavioral changes. Compared to mice only harboring the APPSwDI transgene, these APPSwDI/NOS2 bigenic mice exhibit more severe human Alzheimer's disease pathology and additional human Alzheimer's disease features, and may be useful in studying Alzheimer's disease progression and the role of nitric oxide in altering chronic neurological disease processes.

To generate this double mutant colony, homozygous Tg(Thy1-APPSwDutIowa)BWevn females (from C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax) were bred with heterozygous or homozygous Nos2tm1Lau males (from B6.129P2-Nos2tm1Lau/J). The resulting double mutant animals were bred together to produce this strain.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at the MMRRC at The Jackson Laboratory. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 4 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to the MMRRC at The Jackson Laboratory were on a mixed C57BL/6J ; C57BL/6N genetic background.

Related Strains

Alzheimer's Disease Models
005987   129-Achetm1Loc/J
006409   129S1.129(Cg)-Tg(APPSw)40Btla/Mmjax
008077   129S1/Sv-Bchetm1Loc/J
016198   129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ
014556   129S6/SvEv-Apoetm4Mae/J
006555   A.129(B6)-Tg(APPSw)40Btla/Mmjax
005708   B6.129-Apbb1tm1Quhu/J
004714   B6.129-Bace1tm1Pcw/J
004098   B6.129-Klc1tm1Gsn/J
004193   B6.129-Psen1tm1Mpm/J
003615   B6.129-Psen1tm1Shn/J
005300   B6.129-Tg(APPSw)40Btla/Mmjax
005617   B6.129P-Psen2tm1Bdes/J
002609   B6.129P2-Nos2tm1Lau/J
007685   B6.129P2-Psen1tm1Vln/J
007999   B6.129P2-Sorl1Gt(Ex255)Byg/J
008087   B6.129S1-Bchetm1Loc/J
002509   B6.129S2-Plautm1Mlg/J
005301   B6.129S2-Tg(APP)8.9Btla/J
004163   B6.129S4-Cdk5r1tm1Lht/J
010959   B6.129S4-Grk5tm1Rjl/J
010960   B6.129S4-Grk5tm2Rjl/J
002213   B6.129S4-Ngfrtm1Jae/J
006406   B6.129S4-Tg(APPSwLon)96Btla/Mmjax
006469   B6.129S4-Tg(PSEN1H163R)G9Btla/J
012564   B6.129S5-Dhcr24tm1Lex/SbpaJ
004142   B6.129S7-Aplp2tm1Dbo/J
004133   B6.129S7-Apptm1Dbo/J
007251   B6.129X1-Mapttm1Hnd/J
013040   B6.Cg-Apoetm1Unc Ins2Akita/J
005642   B6.Cg-Clutm1Jakh/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
005866   B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
005864   B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
016197   B6.Cg-Tg(CAG-OTC/CAT)4033Prab/J
005855   B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
007004   B6.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
004996   B6.Cg-Tg(DBH-Gal)1923Stei/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
004662   B6.Cg-Tg(PDGFB-APP)5Lms/J
006293   B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax
006006   B6.Cg-Tg(Prnp-APP)A-2Dbo/J
008596   B6.Cg-Tg(Prnp-Abca1)EHol/J
006005   B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/Mmjax
007180   B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J
007182   B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007051   B6.Cg-Tg(tetO-APPSwInd)102Dbo/Mmjax
007052   B6.Cg-Tg(tetO-APPSwInd)107Dbo/Mmjax
007049   B6.Cg-Tg(tetO-APPSwInd)885Dbo/Mmjax
009337   B6.FVB-Tg(Prnp-RTN3)2Yanr/J
006394   B6;129-Apba2tm1Sud Apba3tm1Sud Apba1tm1Sud/J
008364   B6;129-Chattm1(cre/ERT)Nat/J
008476   B6;129-Ncstntm1Sud/J
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007605   B6;129P-Psen1tm1Vln/J
005618   B6;129P2-Bace2tm1Bdes/J
008333   B6;129P2-Dldtm1Ptl/J
002596   B6;129P2-Nos2tm1Lau/J
003822   B6;129S-Psen1tm1Shn/J
012639   B6;129S4-Mapttm3(HDAC2)Jae/J
012869   B6;129S6-Apbb2tm1Her/J
006410   B6;129S6-Chattm2(cre)Lowl/J
005993   B6;129S6-Pcsk9tm1Jdh/J
008636   B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J
007002   B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/Mmjax
008169   B6;C3-Tg(Prnp-MAPT*P301S)PS19Vle/J
000231   B6;C3Fe a/a-Csf1op/J
008850   B6;SJL-Tg(Mt1-LDLR)93-4Reh/AgnJ
003378   B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J
004462   B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax
003741   B6D2-Tg(Prnp-MAPT)43Vle/J
016556   B6N.129-Ptpn5tm1Pjlo/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
024841   B6N.Cg-Tg(Prnp-MAPT*P301S)PS19Vle/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
012621   C.129S(B6)-Chrna3tm1.1Hwrt/J
002328   C.129S2-Plautm1Mlg/J
003375   C3B6-Tg(APP695)3Dbo/Mmjax
005087   C57BL/6-Tg(Camk2a-IDE)1Selk/J
005086   C57BL/6-Tg(Camk2a-MME)3Selk/J
008833   C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618   C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
006472   D2.129(B6)-Tg(APPSw)40Btla/Mmjax
007067   D2.129P2(B6)-Apoetm1Unc/J
013719   D2.Cg-Apoetm1Unc Ins2Akita/J
003718   FVB-Tg(GadGFP)45704Swn/J
013732   FVB-Tg(NPEPPS)1Skar/J
013156   FVB-Tg(tetO-CDK5R1*)1Vln/J
015815   FVB-Tg(tetO-MAPT*P301L)#Kha/JlwsJ
002329   FVB.129S2-Plautm1Mlg/J
025105   FVB.Cg-Tg(Camk2a-tTA)1Mmay/DboJ
003753   FVB/N-Tg(Eno2CDK5R1)1Jdm/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
025104   FVB/N-Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo/J
008051   NOD.129P2(B6)-Ctsbtm1Jde/RclJ
008390   STOCK Apptm1Sud/J
012640   STOCK Hdac2tm1.2Rdp/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
014092   STOCK Tg(ACTB-tTA2,-MAPT/lacZ)1Luo/J
014544   STOCK Tg(tetO-ABL1*P242E*P249E)CPdav/J
View Alzheimer's Disease Models     (111 strains)

Strains carrying   Nos2tm1Lau allele
002609   B6.129P2-Nos2tm1Lau/J
004684   B6.Cg-chtl Nos2tm1Lau/GrsrJ
002596   B6;129P2-Nos2tm1Lau/J
007072   CByJ.129P2(B6)-Nos2tm1Lau/J
022350   MRL.Cg-Nos2tm1Lau Faslpr/J
View Strains carrying   Nos2tm1Lau     (5 strains)

Strains carrying   Tg(Thy1-APPSwDutIowa)BWevn allele
007027   C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/Mmjax
View Strains carrying   Tg(Thy1-APPSwDutIowa)BWevn     (1 strain)

View Strains carrying other alleles of APP     (15 strains)

Strains carrying other alleles of Thy1
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
001317   B6.Cg-Gpi1a Thy1a Igha/J
017798   B6.Cg-Mapttm1Hnd Tg(Thy1-MAPT*)3610Gds/Mmjax
025855   B6.Cg-Ptprca Lag3tm1Doi Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
008730   B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
007901   B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911   B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710   B6.Cg-Tg(Thy1-CFP)23Jrs/J
014131   B6.Cg-Tg(Thy1-CFP)IJrs/GfngJ
007940   B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007967   B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J
012597   B6.Cg-Tg(Thy1-COL25A1)861Yfu/J
007612   B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615   B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
013161   B6.Cg-Tg(Thy1-Clomeleon)1Gjau/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
005630   B6.Cg-Tg(Thy1-EYFP)15Jrs/J
009611   B6.Cg-Tg(Thy1-Nlgn1)6Hnes/J
009612   B6.Cg-Tg(Thy1-Nlgn2)6Hnes/J
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
003709   B6.Cg-Tg(Thy1-YFP)16Jrs/J
003782   B6.Cg-Tg(Thy1-YFP)HJrs/J
005627   B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
000406   B6.PL-Thy1a/CyJ
000983   B6.PL/(84NS)CyJ
004807   B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/Mmjax
007910   B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
017892   B6;CBA-Tg(Thy1-GCaMP2.2c)8Gfng/J
017893   B6;CBA-Tg(Thy1-GCaMP3)6Gfng/J
014130   B6;CBA-Tg(Thy1-YFP)GJrs/GfngJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
012341   B6;SJL-Tg(Thy1-COP3/EYFP)1Gfng/J
012344   B6;SJL-Tg(Thy1-COP3/EYFP)4Gfng/J
012348   B6;SJL-Tg(Thy1-COP3/EYFP)8Gfng/J
012350   B6;SJL-Tg(Thy1-COP4*H134R/EYFP)20Gfng/J
008004   B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
012836   B6;SJL-Tg(Thy1-TARDBP)4Singh/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
012332   B6;SJL-Tg(Thy1-hop/EYFP)2Gfng/J
012334   B6;SJL-Tg(Thy1-hop/EYFP)4Gfng/J
006554   B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
025401   B6SJL-Tg(Thy1-COX8A/Dendra)57Gmnf/J
017590   B6SJL-Tg(Thy1-DCTN1*G59S)M2Pcw/J
007880   B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856   B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
017589   B6SJL-Tg(Thy1-TARDBP*G298S)S97Pcw/J
017351   BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J
007687   BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J
007686   BKa.Cg-Sox17tm2Sjm Ptprcb Thy1a/J
024703   C3A.Cg-Pde6b+Tg(Thy1-CFP)23Jrs/SjJ
027258   C57BL/6-Tg(Thy1-EGFP/SQSTM1)02Mcwo/J
010800   C57BL/6-Tg(Thy1-PTGS2)300Kand/J
010703   C57BL/6-Tg(Thy1-PTGS2)303Kand/J
012769   C57BL/6-Tg(Thy1-Sncg)HvP36Putt/J
024339   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.11Dkim/J
025393   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.17Dkim/J
024276   C57BL/6J-Tg(Thy1-GCaMP6f)GP5.5Dkim/J
025776   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.12Dkim/J
024275   C57BL/6J-Tg(Thy1-GCaMP6s)GP4.3Dkim/J
025533   C57BL/6N-Sncatm1Mjff Tg(Thy1-SNCA)15Mjff/J
016936   C57BL/6N-Tg(Thy1-SNCA)12Mjff/J
017682   C57BL/6N-Tg(Thy1-SNCA)15Mjff/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005443   CBy.PL(B6)-Thy1a/ScrJ
024704   D2.Cg-Gpnmb+Tg(Thy1-CFP)23Jrs/SjJ
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
026854   D2.Cg-Tg(Thy1-Brainbow1.0)LLich/SjJ
018671   D2.Cg-Tg(Thy1-CFP)23Jrs/SjJ
024705   D2.Cg-Tg(Thy1-YFP)HJrs/SjJ
008230   FVB(Cg)-Tg(Thy1-SOD1*G93A)T3Hgrd/J
006143   FVB/N-Tg(Thy1-cre)1Vln/J
024476   NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004483   NOD.NON-Thy1a/1LtJ
002721   NOD.NON-Thy1a/J
005651   SJL.AK-Thy1a/TseJ
003961   SJL.Cg Thy1a-Noxo1hslt/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
View Strains carrying other alleles of Thy1     (93 strains)

Additional Web Information

Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.


Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Alzheimer Disease; AD
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Hypertension, Essential   (NOS2)
Malaria, Susceptibility to   (NOS2)
- Potential model based on transgenic expression of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Cerebral Amyloid Angiopathy, App-Related   (APP)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Nos2tm1Lau/Nos2tm1Lau Tg(Thy1-APPSwDutIowa)BWevn/?

        involves: C57BL/6
  • nervous system phenotype
  • abnormal brain interneuron morphology
    • 65% loss of NPY interneurons in the hippocampus   (MGI Ref ID J:143551)
  • abnormal hippocampus CA3 region morphology
    • neuronal loss   (MGI Ref ID J:143551)
    • thinning of the CA3 and subiculum, with a 40% loss of neurons in the CA3 region   (MGI Ref ID J:132221)
  • abnormal subiculum morphology
    • neuronal loss   (MGI Ref ID J:143551)
    • 35% loss of neurons in the subiculum   (MGI Ref ID J:132221)
  • amyloid beta deposits
    • deposits are observed by 52 weeks of age   (MGI Ref ID J:143551)
    • amyloid beta deposits in the hippocampus, in the subiculum and thalamus   (MGI Ref ID J:132221)
  • decreased neuron number
    • neuronal loss is observed in hippocampus, subiculum and CA3   (MGI Ref ID J:143551)
  • increased neuron apoptosis   (MGI Ref ID J:132221)
  • neurodegeneration
    • 30% loss of NeuN-immunopositive neurons in the hippocampus, 35% loss in the subiculum, and 40% loss in the CA3 region of the hippocampus   (MGI Ref ID J:132221)
    • loss of neuropeptide Y-immunopositive neurons particularly in the CA3 region and in the subiculum   (MGI Ref ID J:132221)
    • hippocampal neuron degeneration
      • 30% loss of neurons in the hippocampus   (MGI Ref ID J:132221)
      • 50% reduction in neuropeptide Y-immunopositive neurons overall throughout the hippocampus, a 65% reduction in the CA3 region, and 50% reduction in the subiculum   (MGI Ref ID J:132221)
  • tau protein deposits
    • mice show intraneuronal aggregrates of tau   (MGI Ref ID J:132221)
    • hyperphosphorylated tau is seen in the brain and in neuronal processes associated with blood vessels   (MGI Ref ID J:132221)
  • homeostasis/metabolism phenotype
  • amyloid beta deposits
    • deposits are observed by 52 weeks of age   (MGI Ref ID J:143551)
    • amyloid beta deposits in the hippocampus, in the subiculum and thalamus   (MGI Ref ID J:132221)
  • behavior/neurological phenotype
  • abnormal spatial reference memory
    • mice make more errors in the radial-arm water maze than single Tg(Thy1-APPSwDutIowa)BWevn transgenics, especially on subsequent days, indicating slowed learning and/or retrieval of the task   (MGI Ref ID J:132221)
    • mice show increased impaired performance on the Barnes maze compared to single Tg(Thy1-APPSwDutIowa)BWevn transgenics   (MGI Ref ID J:132221)
  • cellular phenotype
  • increased neuron apoptosis   (MGI Ref ID J:132221)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Internal/Organ Research
Wound Healing

Metabolism Research
Free Radical Research

Neurobiology Research
Alzheimer's Disease
      strains expressing mutant APP
Behavioral and Learning Defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin
Neurobiology Research
Toxicology Research
      free radical research

APP related

Neurobiology Research

Nos2tm1Lau related

Immunology, Inflammation and Autoimmunity Research
      Inflammatory bowel disease

Neurobiology Research
Alzheimer's Disease

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Nos2tm1Lau
Allele Name targeted mutation 1, Victor E Laubach
Allele Type Targeted (Null/Knockout)
Common Name(s) NOS2-; NOS2tm/Lau; Nos2tm1Lau; iNOS KO; iNOS-;
Mutation Made ByDr. Victor Laubach,   University of Virginia Health Sci. Ctr.
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Nos2, nitric oxide synthase 2, inducible
Chromosome 11
Gene Common Name(s) HEP-NOS; INOS; NOS; NOS-II; NOS2A; Nos-2; nitric oxide synthase-2 (brain);
Molecular Note A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. [MGI Ref ID J:183641] [MGI Ref ID J:29677]
Allele Symbol Tg(Thy1-APPSwDutIowa)BWevn
Allele Name transgene insertion B, William E Van Nostrand
Allele Type Transgenic (Humanized sequence, Inserted expressed sequence)
Common Name(s) APPSwDI; Tg-SwDI; Tg-SwDI/B;
Mutation Made By William Van Nostrand,   Stony Brook University
Strain of OriginC57BL/6
Expressed Gene APP, amyloid beta (A4) precursor protein, human
Promoter Thy1, thymus cell antigen 1, theta, mouse, laboratory
Molecular Note A transgenic construct containing 2.1kb of the human amyloid beta-precursor protein, APP gene, 770 isoform, with the Swedish K670N/M671L, Dutch E693Q and Iowa D694N mutations, under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter was injected into fertilized C57BL/6 mouse eggs. Founder line B was subsequently established and homozygotes generated. Human amyloid beta precursor protein expression is detected in the brains of transgenic mice. Two other lines, A anc C were also generated, with line A having similar levels of transgene expression and amyloid beta accumulation to line B while line C has 2-fold higher expression of human Amyloid beta-precursor protein and shows 4-fold higher accumulations of soluble and insoluble AB peptides in the brain. [MGI Ref ID J:89848]


Genotyping Information

Genotyping Protocols

Nos2tm1Laualternate4, High Resolution Melting
Generic Tg(APP), Standard PCR
Tg(APP), Separated QPCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Colton CA; Wilcock DM; Wink DA; Davis J; Van Nostrand WE; Vitek MP. 2008. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15(4):571-87. [PubMed: 19096157]  [MGI Ref ID J:143551]

Additional References

Nos2tm1Lau related

Abu-Ghanem Y; Cohen H; Buskila Y; Grauer E; Amitai Y. 2008. Enhanced stress reactivity in nitric oxide synthase type 2 mutant mice: findings in support of astrocytic nitrosative modulation of behavior. Neuroscience 156(2):257-65. [PubMed: 18723080]  [MGI Ref ID J:141014]

Adams LB; Job CK; Krahenbuhl JL. 2000. Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 68(9):5462-5. [PubMed: 10948185]  [MGI Ref ID J:64036]

Aheng C; Ly N; Kelly M; Ibrahim S; Ricquier D; Alves-Guerra MC; Miroux B. 2011. Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis. PLoS One 6(8):e22841. [PubMed: 21857957]  [MGI Ref ID J:176503]

Ahn B; Ohshima H. 2001. Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res 61(23):8357-60. [PubMed: 11731407]  [MGI Ref ID J:73152]

Akita Y; Otani H; Matsuhisa S; Kyoi S; Enoki C; Hattori R; Imamura H; Kamihata H; Kimura Y; Iwasaka T. 2007. Exercise-induced activation of cardiac sympathetic nerve triggers cardioprotection via redox-sensitive activation of eNOS and upregulation of iNOS. Am J Physiol Heart Circ Physiol 292(5):H2051-9. [PubMed: 17259438]  [MGI Ref ID J:125942]

Al Gadban MM; German J; Truman JP; Soodavar F; Riemer EC; Twal WO; Smith KJ; Heller D; Hofbauer AF; Oates JC; Hammad SM. 2012. Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus. Cell Immunol 276(1-2):42-51. [PubMed: 22560558]  [MGI Ref ID J:188295]

Anand RJ; Dai S; Rippel C; Leaphart C; Qureshi F; Gribar SC; Kohler JW; Li J; Stolz DB; Sodhi C; Hackam DJ. 2008. Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide. Am J Physiol Gastrointest Liver Physiol 294(1):G109-19. [PubMed: 17975131]  [MGI Ref ID J:130509]

Ando A; Yang A; Mori K; Yamada H; Yamada E; Takahashi K; Saikia J; Kim M; Melia M; Fishman M; Huang P; Campochiaro PA. 2002. Nitric oxide is proangiogenic in the retina and choroid. J Cell Physiol 191(1):116-24. [PubMed: 11920687]  [MGI Ref ID J:106207]

Andrade RM; Portillo JA; Wessendarp M; Subauste CS. 2005. CD40 signaling in macrophages induces activity against an intracellular pathogen independently of gamma interferon and reactive nitrogen intermediates. Infect Immun 73(5):3115-23. [PubMed: 15845519]  [MGI Ref ID J:97614]

Arantes RM; Marche HH; Bahia MT; Cunha FQ; Rossi MA; Silva JS. 2004. Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice. Am J Pathol 164(4):1361-8. [PubMed: 15039223]  [MGI Ref ID J:89108]

Arnett HA; Hellendall RP; Matsushima GK; Suzuki K; Laubach VE; Sherman P; Ting JP. 2002. The protective role of nitric oxide in a neurotoxicant-induced demyelinating model. J Immunol 168(1):427-33. [PubMed: 11751989]  [MGI Ref ID J:125459]

Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. [PubMed: 21576342]  [MGI Ref ID J:173478]

Barrios B; Baez NS; Reynolds D; Iribarren P; Cejas H; Young HA; Rodriguez-Galan MC. 2014. Abrogation of TNFalpha production during cancer immunotherapy is crucial for suppressing side effects due to the systemic expression of IL-12. PLoS One 9(2):e90116. [PubMed: 24587231]  [MGI Ref ID J:214472]

Bartholdy C; Nansen A; Christensen JE; Marker O; Thomsen AR. 1999. Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. J Gen Virol 80(Pt 11):2997-3005. [PubMed: 10580062]  [MGI Ref ID J:103345]

Bast A; Erttmann SF; Walther R; Steinmetz I. 2010. Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages. Free Radic Biol Med 49(12):1881-91. [PubMed: 20869433]  [MGI Ref ID J:167094]

Becerril S; Rodriguez A; Catalan V; Sainz N; Ramirez B; Collantes M; Penuelas I; Gomez-Ambrosi J; Fruhbeck G. 2010. Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function. PLoS One 5(6):e10962. [PubMed: 20532036]  [MGI Ref ID J:161815]

Beck PL; Li Y; Wong J; Chen CW; Keenan CM; Sharkey KA; McCafferty DM. 2007. Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132(5):1778-90. [PubMed: 17449036]  [MGI Ref ID J:128325]

Beck PL; Xavier R; Wong J; Ezedi I; Mashimo H; Mizoguchi A; Mizoguchi E; Bhan AK; Podolsky DK. 2004. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol 286(1):G137-47. [PubMed: 14665440]  [MGI Ref ID J:87601]

Beisiegel M; Mollenkopf HJ; Hahnke K; Koch M; Dietrich I; Reece ST; Kaufmann SH. 2009. Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host. Eur J Immunol 39(12):3369-84. [PubMed: 19795415]  [MGI Ref ID J:155483]

Bhandari V; Choo-Wing R; Harijith A; Sun H; Syed MA; Homer RJ; Elias JA. 2012. Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol 46(5):668-76. [PubMed: 22227562]  [MGI Ref ID J:196034]

Blanchard TG; Yu F; Hsieh CL; Redline RW. 2003. Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. J Infect Dis 187(10):1609-15. [PubMed: 12721941]  [MGI Ref ID J:120653]

Blyszczuk P; Berthonneche C; Behnke S; Glonkler M; Moch H; Pedrazzini T; Luscher TF; Eriksson U; Kania G. 2013. Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis. Cardiovasc Res 97(2):219-29. [PubMed: 23090609]  [MGI Ref ID J:210288]

Bokhari SM; Kim KJ; Pinson DM; Slusser J; Yeh HW; Parmely MJ. 2008. NK cells and gamma interferon coordinate the formation and function of hepatic granulomas in mice infected with the Francisella tularensis live vaccine strain. Infect Immun 76(4):1379-89. [PubMed: 18227174]  [MGI Ref ID J:133531]

Boyer L; Plantier L; Dagouassat M; Lanone S; Goven D; Caramelle P; Berrehar F; Kerbrat S; Dinh-Xuan AT; Crestani B; Le Gouvello S; Boczkowski J. 2011. Role of nitric oxide synthases in elastase-induced emphysema. Lab Invest 91(3):353-62. [PubMed: 20956973]  [MGI Ref ID J:169267]

Brahmachari S; Pahan K. 2010. Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide. J Immunol 184(4):1799-809. [PubMed: 20083653]  [MGI Ref ID J:159486]

Brahmachari S; Pahan K. 2009. Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. J Immunol 183(3):2045-58. [PubMed: 19587012]  [MGI Ref ID J:151706]

Bratt JM; Franzi LM; Linderholm AL; Last MS; Kenyon NJ; Last JA. 2009. Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol 234(3):273-80. [PubMed: 19027033]  [MGI Ref ID J:145875]

Breitbach K; Klocke S; Tschernig T; van Rooijen N; Baumann U; Steinmetz I. 2006. Role of Inducible Nitric Oxide Synthase and NADPH Oxidase in Early Control of Burkholderia pseudomallei Infection in Mice. Infect Immun 74(11):6300-6309. [PubMed: 17000727]  [MGI Ref ID J:113561]

Brumshagen C; Maus R; Bischof A; Ueberberg B; Bohling J; Osterholzer JJ; Ogunniyi AD; Paton JC; Welte T; Maus UA. 2012. FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin. Infect Immun 80(12):4281-90. [PubMed: 23006850]  [MGI Ref ID J:190619]

Buhtoiarov IN; Lum HD; Berke G; Sondel PM; Rakhmilevich AL. 2006. Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects. J Immunol 176(1):309-18. [PubMed: 16365423]  [MGI Ref ID J:126263]

Burrer R; Buchmeier MJ; Wolfe T; Ting JP; Feuer R; Iglesias A; von Herrath MG. 2007. Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies. Am J Pathol 170(2):557-66. [PubMed: 17255324]  [MGI Ref ID J:117906]

Buskila Y; Abu-Ghanem Y; Levi Y; Moran A; Grauer E; Amitai Y. 2007. Enhanced astrocytic nitric oxide production and neuronal modifications in the neocortex of a NOS2 mutant mouse. PLoS ONE 2(9):e843. [PubMed: 17786214]  [MGI Ref ID J:129384]

Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P. 2002. Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent. Eur J Immunol 32(11):3206-15. [PubMed: 12555666]  [MGI Ref ID J:115538]

Cambien B; Bergmeier W; Saffaripour S; Mitchell HA; Wagner DD. 2003. Antithrombotic activity of TNF-alpha. J Clin Invest 112(10):1589-96. [PubMed: 14617760]  [MGI Ref ID J:117987]

Carnio EC; Stabile AM; Batalhao ME; Silva JS; Antunes-Rodrigues J; Branco LG; Magder S. 2005. Vasopressin release during endotoxaemic shock in mice lacking inducible nitric oxide synthase. Pflugers Arch 450(6):390-4. [PubMed: 15971084]  [MGI Ref ID J:106197]

Cauwels A; Janssen B; Buys E; Sips P; Brouckaert P. 2006. Anaphylactic shock depends on PI3K and eNOS-derived NO. J Clin Invest 116(8):2244-51. [PubMed: 16886062]  [MGI Ref ID J:113106]

Cauwels A; Van Molle W; Janssen B; Everaerdt B; Huang P; Fiers W; Brouckaert P. 2000. Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase. Immunity 13(2):223-31. [PubMed: 10981965]  [MGI Ref ID J:64176]

Cha HN; Kim YW; Kim JY; Kim YD; Song IH; Min KN; Park SY. 2010. Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance. Exp Gerontol 45(9):711-8. [PubMed: 20493940]  [MGI Ref ID J:164264]

Chan JY; Cooney GJ; Biden TJ; Laybutt DR. 2011. Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia 54(7):1766-76. [PubMed: 21472432]  [MGI Ref ID J:172611]

Charbonneau A; Marette A. 2010. Inducible nitric oxide synthase induction underlies lipid-induced hepatic insulin resistance in mice: potential role of tyrosine nitration of insulin signaling proteins. Diabetes 59(4):861-71. [PubMed: 20103705]  [MGI Ref ID J:164330]

Chatterjee S; Lardinois O; Bonini MG; Bhattacharjee S; Stadler K; Corbett J; Deterding LJ; Tomer KB; Kadiiska M; Mason RP. 2009. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol 183(6):4055-66. [PubMed: 19717511]  [MGI Ref ID J:152293]

Chauhan SD; Seggara G; Vo PA; Macallister RJ; Hobbs AJ; Ahluwalia A. 2003. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17(6):773-5. [PubMed: 12586741]  [MGI Ref ID J:118016]

Chen L; Majde JA; Krueger JM. 2003. Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973(2):214-22. [PubMed: 12738065]  [MGI Ref ID J:83571]

Chen L; Taishi P; Duricka D; Krueger JM. 2004. Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Brain Res Mol Brain Res 129(1-2):179-84. [PubMed: 15469894]  [MGI Ref ID J:115454]

Chen L; Taishi P; Majde JA; Peterfi Z; Obal F Jr; Krueger JM. 2004. The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha. Brain Behav Immun 18(4):390-8. [PubMed: 15157956]  [MGI Ref ID J:105452]

Chiang E; Dang O; Anderson K; Matsuzawa A; Ichijo H; David M. 2006. Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol 176(10):5720-4. [PubMed: 16670275]  [MGI Ref ID J:131688]

Choi KS; Song EK; Yim CY. 2008. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. J Leukoc Biol 83(6):1440-50. [PubMed: 18339892]  [MGI Ref ID J:136847]

Chyu KY; Dimayuga P; Zhu J; Nilsson J; Kaul S; Shah PK; Cercek B. 1999. Decreased neointimal thickening after arterial wall injury in inducible nitric oxide synthase knockout mice. Circ Res 85(12):1192-8. [PubMed: 10590247]  [MGI Ref ID J:59834]

Cohen O; Ish-Shalom E; Kfir-Erenfeld S; Herr I; Yefenof E. 2012. Nitric oxide and glucocorticoids synergize in inducing apoptosis of CD4(+)8(+) thymocytes: implications for 'Death by Neglect' and T-cell function. Int Immunol 24(12):783-91. [PubMed: 22949567]  [MGI Ref ID J:190546]

Cole C; Thomas S; Filak H; Henson PM; Lenz LL. 2012. Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity 36(5):807-20. [PubMed: 22542147]  [MGI Ref ID J:187324]

Cole MP; Chaiswing L; Oberley TD; Edelmann SE; Piascik MT; Lin SM; Kiningham KK; St Clair DK. 2006. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 69(1):186-97. [PubMed: 16157314]  [MGI Ref ID J:133742]

Cole MP; Tangpong J; Oberley TD; Chaiswing L; Kiningham KK; St Clair DK. 2014. Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice. PLoS One 9(2):e89251. [PubMed: 24586632]  [MGI Ref ID J:213759]

Collazo CM; Meierovics AI; De Pascalis R; Wu TH; Lyons CR; Elkins KL. 2009. T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteria. Infect Immun 77(5):2010-21. [PubMed: 19237526]  [MGI Ref ID J:148524]

Colton CA; Vitek MP; Wink DA; Xu Q; Cantillana V; Previti ML; Van Nostrand WE; Weinberg B; Dawson H. 2006. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 103(34):12867-72. [PubMed: 16908860]  [MGI Ref ID J:112919]

Comtois AS; El-Dwairi Q; Laubach VE; Hussain SN. 1999. Lipopolysaccharide-induced diaphragmatic contractile dysfunction in mice lacking the inducible nitric oxide synthase. Am J Respir Crit Care Med 159(6):1975-80. [PubMed: 10351947]  [MGI Ref ID J:57227]

Cowley SC; Hamilton E; Frelinger JA; Su J; Forman J; Elkins KL. 2005. CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo. J Exp Med 202(2):309-19. [PubMed: 16027239]  [MGI Ref ID J:100513]

Cuenca J; Martin-Sanz P; Alvarez-Barrientos AM; Bosca L; Goren N. 2006. Infiltration of Inflammatory Cells Plays an Important Role in Matrix Metalloproteinase Expression and Activation in the Heart during Sepsis. Am J Pathol 169(5):1567-76. [PubMed: 17071581]  [MGI Ref ID J:114564]

Cusumano ZT; Watson ME Jr; Caparon MG. 2014. Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity. Infect Immun 82(1):233-42. [PubMed: 24144727]  [MGI Ref ID J:206198]

D'Alessio FR; Tsushima K; Aggarwal NR; Mock JR; Eto Y; Garibaldi BT; Files DC; Avalos CR; Rodriguez JV; Waickman AT; Reddy SP; Pearse DB; Sidhaye VK; Hassoun PM; Crow MT; King LS. 2012. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol 189(5):2234-45. [PubMed: 22844117]  [MGI Ref ID J:189863]

Dai M; Yang Y; Omelchenko I; Nuttall AL; Kachelmeier A; Xiu R; Shi X. 2010. Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier. Am J Pathol 177(6):3089-99. [PubMed: 21057001]  [MGI Ref ID J:167627]

Dal Secco D; Paron JA; de Oliveira SH; Ferreira SH; Silva JS; Cunha Fde Q. 2003. Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis. Nitric Oxide 9(3):153-64. [PubMed: 14732339]  [MGI Ref ID J:118999]

Dallaire P; Bellmann K; Laplante M; Gelinas S; Centeno-Baez C; Penfornis P; Peyot ML; Latour MG; Lamontagne J; Trujillo ME; Scherer PE; Prentki M; Deshaies Y; Marette A. 2008. Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism. Diabetes 57(8):1999-2011. [PubMed: 18458147]  [MGI Ref ID J:141699]

Davie SA; Maglione JE; Manner CK; Young D; Cardiff RD; MacLeod CL; Ellies LG. 2007. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice. Transgenic Res 16(2):193-201. [PubMed: 17206489]  [MGI Ref ID J:121391]

De Luca G; Di Giorgio RM; Macaione S; Calpona PR; Di Paola ED; Costa N; Cuzzocrea S; Citraro R; Russo E; De Sarro G. 2006. Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling. Pharmacol Biochem Behav 85(4):804-12. [PubMed: 17223186]  [MGI Ref ID J:124504]

Demchenko IT; Atochin DN; Gutsaeva DR; Godfrey RR; Huang PL; Piantadosi CA; Allen BW. 2008. Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. Am J Physiol Lung Cell Mol Physiol 294(5):L984-90. [PubMed: 18326824]  [MGI Ref ID J:136632]

Denda A; Kitayama W; Kishida H; Murata N; Tamura K; Kusuoka O; Tsutsumi M; Nishikawa F; Kita E; Nakae D; Konishi Y; Kuniyasu H. 2007. Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, L-amino acid-defined diet in rats and mice. Nitric Oxide 16(1):164-76. [PubMed: 16931074]  [MGI Ref ID J:118071]

Deppong CM; Bricker TL; Rannals BD; Van Rooijen N; Hsieh CS; Green JM. 2013. CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-beta. J Immunol 191(6):3082-9. [PubMed: 23956428]  [MGI Ref ID J:205876]

Dhar N; McKinney JD. 2010. Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice. Proc Natl Acad Sci U S A 107(27):12275-80. [PubMed: 20566858]  [MGI Ref ID J:162073]

Di Marco S; Mazroui R; Dallaire P; Chittur S; Tenenbaum SA; Radzioch D; Marette A; Gallouzi IE. 2005. NF-(kappa)B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol 25(15):6533-45. [PubMed: 16024790]  [MGI Ref ID J:100108]

DiMagno MJ; Hao Y; Tsunoda Y; Williams JA; Owyang C. 2004. Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice. Am J Physiol Gastrointest Liver Physiol 286(3):G428-36. [PubMed: 14551061]  [MGI Ref ID J:95674]

Dias MB; Almeida MC; Carnio EC; Branco LG. 2005. Role of nitric oxide in tolerance to lipopolysaccharide in mice. J Appl Physiol 98(4):1322-7. [PubMed: 15579566]  [MGI Ref ID J:110018]

Diesen DL; Hess DT; Stamler JS. 2008. Hypoxic vasodilation by red blood cells: evidence for an s-nitrosothiol-based signal. Circ Res 103(5):545-53. [PubMed: 18658051]  [MGI Ref ID J:152645]

Duque-Correa MA; Kuhl AA; Rodriguez PC; Zedler U; Schommer-Leitner S; Rao M; Weiner J 3rd; Hurwitz R; Qualls JE; Kosmiadi GA; Murray PJ; Kaufmann SH; Reece ST. 2014. Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proc Natl Acad Sci U S A 111(38):E4024-32. [PubMed: 25201986]  [MGI Ref ID J:216485]

Edelson BT; Unanue ER. 2002. MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity. J Immunol 169(7):3869-75. [PubMed: 12244184]  [MGI Ref ID J:120406]

Eigenbrod T; Bode KA; Dalpke AH. 2013. Early inhibition of IL-1beta expression by IFN-gamma is mediated by impaired binding of NF-kappaB to the IL-1beta promoter but is independent of nitric oxide. J Immunol 190(12):6533-41. [PubMed: 23667107]  [MGI Ref ID J:204860]

Ellies LG. 2003. PyV-mT-induced parotid gland hyperplasia as detected by altered lectin reactivity is not modulated by inducible nitric oxide deficiency. Arch Oral Biol 48(6):415-22. [PubMed: 12749913]  [MGI Ref ID J:84218]

Ellies LG; Fishman M; Hardison J; Kleeman J; Maglione JE; Manner CK; Cardiff RD; MacLeod CL. 2003. Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase. Int J Cancer 106(1):1-7. [PubMed: 12794750]  [MGI Ref ID J:84004]

Everts B; Amiel E; Huang SC; Smith AM; Chang CH; Lam WY; Redmann V; Freitas TC; Blagih J; van der Windt GJ; Artyomov MN; Jones RG; Pearce EL; Pearce EJ. 2014. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol 15(4):323-32. [PubMed: 24562310]  [MGI Ref ID J:209894]

Everts B; Amiel E; van der Windt GJ; Freitas TC; Chott R; Yarasheski KE; Pearce EL; Pearce EJ. 2012. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120(7):1422-31. [PubMed: 22786879]  [MGI Ref ID J:189164]

Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. [PubMed: 17372191]  [MGI Ref ID J:120115]

Falcone S; Perrotta C; De Palma C; Pisconti A; Sciorati C; Capobianco A; Rovere-Querini P; Manfredi AA; Clementi E. 2004. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 173(7):4452-63. [PubMed: 15383576]  [MGI Ref ID J:93735]

Felmy B; Songhet P; Slack EM; Muller AJ; Kremer M; Van Maele L; Cayet D; Heikenwalder M; Sirard JC; Hardt WD. 2013. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One 8(10):e77204. [PubMed: 24143212]  [MGI Ref ID J:209119]

Feng HM; Walker DH. 2004. Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis. Infect Immun 72(2):966-71. [PubMed: 14742542]  [MGI Ref ID J:87862]

Fernandes KS; Neto EH; Brito MM; Silva JS; Cunha FQ; Barja-Fidalgo C. 2008. Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii. Immunology 123(4):469-79. [PubMed: 18194265]  [MGI Ref ID J:136580]

Fraszczak J; Trad M; Janikashvili N; Cathelin D; Lakomy D; Granci V; Morizot A; Audia S; Micheau O; Lagrost L; Katsanis E; Solary E; Larmonier N; Bonnotte B. 2010. Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells. J Immunol 184(4):1876-84. [PubMed: 20089706]  [MGI Ref ID J:159469]

Fukumura D; Gohongi T; Kadambi A; Izumi Y; Ang J; Yun CO; Buerk DG; Huang PL; Jain RK. 2001. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A 98(5):2604-9. [PubMed: 11226286]  [MGI Ref ID J:67870]

Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. [PubMed: 11426950]  [MGI Ref ID J:102684]

Gaur U; Roberts SC; Dalvi RP; Corraliza I; Ullman B; Wilson ME. 2007. An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis. J Immunol 179(12):8446-53. [PubMed: 18056391]  [MGI Ref ID J:155195]

Gericke A; Goloborodko E; Sniatecki JJ; Steege A; Wojnowski L; Pfeiffer N. 2013. Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles. Exp Eye Res 109:60-6. [PubMed: 23434456]  [MGI Ref ID J:210420]

Ghosn EE; Russo M; Almeida SR. 2006. Nitric oxide-dependent killing of Cryptococcus neoformans by B-1-derived mononuclear phagocyte. J Leukoc Biol 80(1):36-44. [PubMed: 16670124]  [MGI Ref ID J:110472]

Gillman BM; Batchelder J; Flaherty P; Weidanz WP. 2004. Suppression of Plasmodium chabaudi parasitemia is independent of the action of reactive oxygen intermediates and/or nitric oxide. Infect Immun 72(11):6359-66. [PubMed: 15501765]  [MGI Ref ID J:93252]

Giordano D; Li C; Suthar MS; Draves KE; Ma DY; Gale M Jr; Clark EA. 2011. Nitric oxide controls an inflammatory-like Ly6C(hi)PDCA1+ DC subset that regulates Th1 immune responses. J Leukoc Biol 89(3):443-55. [PubMed: 21178115]  [MGI Ref ID J:170375]

Gobert AP; Cheng Y; Akhtar M; Mersey BD; Blumberg DR; Cross RK; Chaturvedi R; Drachenberg CB; Boucher JL; Hacker A; Casero RA Jr; Wilson KT. 2004. Protective role of arginase in a mouse model of colitis. J Immunol 173(3):2109-17. [PubMed: 15265947]  [MGI Ref ID J:92035]

Goldmann O; von Kockritz-Blickwede M; Holtje C; Chhatwal GS; Geffers R; Medina E. 2007. Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program. Infect Immun 75(8):4148-57. [PubMed: 17526748]  [MGI Ref ID J:123374]

Gomes SA; Rangel EB; Premer C; Dulce RA; Cao Y; Florea V; Balkan W; Rodrigues CO; Schally AV; Hare JM. 2013. S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells. Proc Natl Acad Sci U S A 110(8):2834-9. [PubMed: 23288904]  [MGI Ref ID J:193262]

Gomez-Ambrosi J; Becerril S; Oroz P; Zabalza S; Rodriguez A; Muruzabal FJ; Archanco M; Gil MJ; Burrell MA; Fruhbeck G. 2004. Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice: effect of LPS on plasma leptin and adiponectin concentrations. FEBS Lett 577(3):351-6. [PubMed: 15556608]  [MGI Ref ID J:94571]

Gonzalez C; Cuvellier S; Hue-Beauvais C; Levi-Strauss M. 2003. Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes. Diabetologia 46(9):1291-5. [PubMed: 12879252]  [MGI Ref ID J:95957]

Gorbunov NV; Kiang JG. 2009. Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation. J Pathol 219(2):242-52. [PubMed: 19681094]  [MGI Ref ID J:152797]

Gramaglia I; Sobolewski P; Meays D; Contreras R; Nolan JP; Frangos JA; Intaglietta M; van der Heyde HC. 2006. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med 12(12):1417-22. [PubMed: 17099710]  [MGI Ref ID J:129543]

Greenberg SS; Ouyang J; Zhao X; Parrish C; Nelson S; Giles TD. 1999. Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res 23(9):1435-45. [PubMed: 10512307]  [MGI Ref ID J:59745]

Guhring H; Gorig M; Ates M; Coste O; Zeilhofer HU; Pahl A; Rehse K; Brune K. 2000. Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. J Neurosci 20(17):6714-20. [PubMed: 10964977]  [MGI Ref ID J:64215]

Guo Y; Jones WK; Xuan YT; Tang XL; Bao W; Wu WJ; Han H; Laubach VE; Ping P; Yang Z; Qiu Y; Bolli R. 1999. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene [see comments] Proc Natl Acad Sci U S A 96(20):11507-12. [PubMed: 10500207]  [MGI Ref ID J:57975]

Guthrie SM; Curtis LM; Mames RN; Simon GG; Grant MB; Scott EW. 2005. The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells. Blood 105(5):1916-22. [PubMed: 15546953]  [MGI Ref ID J:98135]

Haag D; Zipper P; Westrich V; Karra D; Pfleger K; Toedt G; Blond F; Delhomme N; Hahn M; Reifenberger J; Reifenberger G; Lichter P. 2012. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet 8(3):e1002572. [PubMed: 22438824]  [MGI Ref ID J:183478]

Hamada T; Duarte S; Tsuchihashi S; Busuttil RW; Coito AJ. 2009. Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury. Am J Pathol 174(6):2265-77. [PubMed: 19443702]  [MGI Ref ID J:148923]

Hampton TG; Amende I; Fong J; Laubach VE; Li J; Metais C; Simons M. 2000. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. Am J Physiol Heart Circ Physiol 279(1):H260-8. [PubMed: 10899065]  [MGI Ref ID J:107850]

Hardiman KM; Lindsey JR; Matalon S. 2001. Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo. Am J Physiol Lung Cell Mol Physiol 281(3):L722-31. [PubMed: 11504701]  [MGI Ref ID J:71505]

Hegazi RA; Rao KN; Mayle A; Sepulveda AR; Otterbein LE; Plevy SE. 2005. Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway. J Exp Med 202(12):1703-13. [PubMed: 16365149]  [MGI Ref ID J:118826]

Hernandez-Cuellar E; Tsuchiya K; Hara H; Fang R; Sakai S; Kawamura I; Akira S; Mitsuyama M. 2012. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 189(11):5113-7. [PubMed: 23100513]  [MGI Ref ID J:190677]

Hertz CJ; Mansfield JM. 1999. IFN-gamma-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis. Cell Immunol 192(1):24-32. [PubMed: 10066343]  [MGI Ref ID J:114251]

Hervera A; Leanez S; Negrete R; Motterlini R; Pol O. 2012. Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PLoS One 7(8):e43693. [PubMed: 22928017]  [MGI Ref ID J:191571]

Hickman-Davis JM; Wang Z; Fierro-Perez GA; Chess PR; Page GP; Matalon S; Notter RH. 2007. Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection. Am J Respir Cell Mol Biol 36(1):103-13. [PubMed: 16917077]  [MGI Ref ID J:130520]

Hoang T; Choi DK; Nagai M; Wu DC; Nagata T; Prou D; Wilson GL; Vila M; Jackson-Lewis V; Dawson VL; Dawson TM; Chesselet MF; Przedborski S. 2009. Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. Free Radic Biol Med 47(7):1049-56. [PubMed: 19616617]  [MGI Ref ID J:152538]

Hokari R; Kato S; Matsuzaki K; Kuroki M; Iwai A; Kawaguchi A; Nagao S; Miyahara T; Itoh K; Sekizuka E; Nagata H; Ishii H; Miura S. 2001. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis. Free Radic Biol Med 31(2):153-63. [PubMed: 11440827]  [MGI Ref ID J:70811]

Hollenberg SM; Broussard M; Osman J; Parrillo JE. 2000. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 86(7):774-8. [PubMed: 10764411]  [MGI Ref ID J:110288]

Houpt ER; Glembocki DJ; Obrig TG; Moskaluk CA; Lockhart LA; Wright RL; Seaner RM; Keepers TR; Wilkins TD; Petri WA Jr. 2002. The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol 169(8):4496-503. [PubMed: 12370386]  [MGI Ref ID J:120012]

Hromatka BS; Noble SM; Johnson AD. 2005. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell 16(10):4814-26. [PubMed: 16030247]  [MGI Ref ID J:106530]

Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. [PubMed: 21911464]  [MGI Ref ID J:177771]

Huang B; Pan PY; Li Q; Sato AI; Levy DE; Bromberg J; Divino CM; Chen SH. 2006. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66(2):1123-31. [PubMed: 16424049]  [MGI Ref ID J:106544]

Hussain MB; Hobbs AJ; MacAllister RJ. 1999. Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol 128(5):1082-8. [PubMed: 10556946]  [MGI Ref ID J:59681]

Hussain SP; He P; Subleski J; Hofseth LJ; Trivers GE; Mechanic L; Hofseth AB; Bernard M; Schwank J; Nguyen G; Mathe E; Djurickovic D; Haines D; Weiss J; Back T; Gruys E; Laubach VE; Wiltrout RH; Harris CC. 2008. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res 68(17):7130-6. [PubMed: 18757428]  [MGI Ref ID J:138926]

Hussain SP; Trivers GE; Hofseth LJ; He P; Shaikh I; Mechanic LE; Doja S; Jiang W; Subleski J; Shorts L; Haines D; Laubach VE; Wiltrout RH; Djurickovic D; Harris CC. 2004. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res 64(19):6849-53. [PubMed: 15466171]  [MGI Ref ID J:93662]

Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. [PubMed: 17764851]  [MGI Ref ID J:128390]

Ii M; Nishimura H; Iwakura A; Wecker A; Eaton E; Asahara T; Losordo DW. 2005. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via 'imported' nitric oxide synthase activity. Circulation 111(9):1114-20. [PubMed: 15723985]  [MGI Ref ID J:108997]

Into T; Inomata M; Nakashima M; Shibata K; Hacker H; Matsushita K. 2008. Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol 28(4):1338-47. [PubMed: 18086890]  [MGI Ref ID J:132654]

Isaksson J; Farooque M; Olsson Y. 2005. Improved functional outcome after spinal cord injury in iNOS-deficient mice. Spinal Cord 43(3):167-70. [PubMed: 15520837]  [MGI Ref ID J:110081]

Itzhak Y; Martin JL; Ali SF. 1999. Methamphetamine- and 1-methyl-4-phenyl- 1,2,3, 6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitric oxide synthase-deficient mice. Synapse 34(4):305-12. [PubMed: 10529724]  [MGI Ref ID J:59707]

Iwakiri Y; Cadelina G; Sessa WC; Groszmann RJ. 2002. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. Am J Physiol Gastrointest Liver Physiol 283(5):G1074-81. [PubMed: 12381520]  [MGI Ref ID J:108056]

Jantsch J; Schatz V; Friedrich D; Schroder A; Kopp C; Siegert I; Maronna A; Wendelborn D; Linz P; Binger KJ; Gebhardt M; Heinig M; Neubert P; Fischer F; Teufel S; David JP; Neufert C; Cavallaro A; Rakova N; Kuper C; Beck FX; Neuhofer W; Muller DN; Schuler G; Uder M; Bogdan C; Luft FC; Titze J. 2015. Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab 21(3):493-501. [PubMed: 25738463]  [MGI Ref ID J:220700]

Jayaraman P; Parikh F; Lopez-Rivera E; Hailemichael Y; Clark A; Ma G; Cannan D; Ramacher M; Kato M; Overwijk WW; Chen SH; Umansky VY; Sikora AG. 2012. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188(11):5365-76. [PubMed: 22529296]  [MGI Ref ID J:188746]

Jones SP; Greer JJ; Ware PD; Yang J; Walsh K; Lefer DJ. 2005. Deficiency of iNOS does not attenuate severe congestive heart failure in mice. Am J Physiol Heart Circ Physiol 288(1):H365-70. [PubMed: 15319210]  [MGI Ref ID J:95577]

Jones SP; Trocha SD; Lefer DJ. 2001. Cardioprotective actions of endogenous IL-10 are independent of iNOS. Am J Physiol Heart Circ Physiol 281(1):H48-52. [PubMed: 11406467]  [MGI Ref ID J:70292]

Joo JD; Kim M; Horst P; Kim J; D'Agati VD; Emala CW Sr; Lee HT. 2007. Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. Am J Physiol Renal Physiol 293(6):F1847-57. [PubMed: 17928414]  [MGI Ref ID J:127544]

Kahl KG; Schmidt HH; Jung S; Sherman P; Toyka KV; Zielasek J. 2004. Experimental autoimmune encephalomyelitis in mice with a targeted deletion of the inducible nitric oxide synthase gene: increased T-helper 1 response. Neurosci Lett 358(1):58-62. [PubMed: 15016434]  [MGI Ref ID J:88809]

Kalns J; Scruggs J; Millenbaugh N; Vivekananda J; Shealy D; Eggers J; Kiel J. 2002. TNF Receptor 1, IL-1 Receptor, and iNOS Genetic Knockout Mice Are Not Protected from Anthrax Infection. Biochem Biophys Res Commun 292(1):41-4. [PubMed: 11890668]  [MGI Ref ID J:75694]

Kan MJ; Lee JE; Wilson JG; Everhart AL; Brown CM; Hoofnagle AN; Jansen M; Vitek MP; Gunn MD; Colton CA. 2015. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci 35(15):5969-82. [PubMed: 25878270]  [MGI Ref ID J:221677]

Kania G; Siegert S; Behnke S; Prados-Rosales R; Casadevall A; Luscher TF; Luther SA; Kopf M; Eriksson U; Blyszczuk P. 2013. Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. Circulation 127(23):2285-94. [PubMed: 23671208]  [MGI Ref ID J:211390]

Kenyon NJ; van der Vliet A; Schock BC; Okamoto T; McGrew GM; Last JA. 2002. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol Lung Cell Mol Physiol 282(3):L540-5. [PubMed: 11839550]  [MGI Ref ID J:75613]

Kim HA; Kim SH; Ko HM; Choi JH; Kim KJ; Oh SH; Cho KO; Choi IW; Im SY. 2008. Nitric oxide plays a key role in the platelet-activating factor-induced enhancement of resistance against systemic candidiasis. Immunology 124(3):428-35. [PubMed: 18397269]  [MGI Ref ID J:138455]

Kirksey MA; Tischler AD; Simeone R; Hisert KB; Uplekar S; Guilhot C; McKinney JD. 2011. Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity. Infect Immun 79(7):2829-38. [PubMed: 21576344]  [MGI Ref ID J:173476]

Kisley LR; Barrett BS; Bauer AK; Dwyer-Nield LD; Barthel B; Meyer AM; Thompson DC; Malkinson AM. 2002. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res 62(23):6850-6. [PubMed: 12460898]  [MGI Ref ID J:80325]

Kitayama J; Faraci FM; Gunnett CA; Heistad DD. 2006. Impairment of dilator responses of cerebral arterioles during diabetes mellitus: role of inducible NO synthase. Stroke 37(8):2129-33. [PubMed: 16809563]  [MGI Ref ID J:135707]

Kleeberger SR; Reddy SP; Zhang LY; Cho HY; Jedlicka AE. 2001. Toll-like receptor 4 mediates ozone-induced murine lung hyperpermeability via inducible nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol 280(2):L326-33. [PubMed: 11159012]  [MGI Ref ID J:108671]

Klingstrom J; Akerstrom S; Hardestam J; Stoltz M; Simon M; Falk KI; Mirazimi A; Rottenberg M; Lundkvist A. 2006. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. Eur J Immunol 36(10):2649-57. [PubMed: 16955520]  [MGI Ref ID J:118085]

Knotek M; Rogachev B; Wang W; Ecder T; Melnikov V; Gengaro PE; Esson M; Edelstein CL; Dinarello CA; Schrier RW. 2001. Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int 59(6):2243-9. [PubMed: 11380827]  [MGI Ref ID J:104003]

Knudsen L; Atochina-Vasserman EN; Guo CJ; Scott PA; Haenni B; Beers MF; Ochs M; Gow AJ. 2014. NOS2 is critical to the development of emphysema in Sftpd deficient mice but does not affect surfactant homeostasis. PLoS One 9(1):e85722. [PubMed: 24465666]  [MGI Ref ID J:212338]

Ko J; Gendron-Fitzpatrick A; Splitter GA. 2002. Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis. J Immunol 168(5):2433-40. [PubMed: 11859135]  [MGI Ref ID J:74725]

Kotamraju S; Matalon S; Matsunaga T; Shang T; Hickman-Davis JM; Kalyanaraman B. 2006. Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells. Free Radic Biol Med 40(6):1034-44. [PubMed: 16540399]  [MGI Ref ID J:107075]

Kozak W; Kozak A. 2003. Genetic Models in Applied Physiology. Differential role of nitric oxide synthase isoforms in fever of different etiologies: studies using Nos gene-deficient mice. J Appl Physiol 94(6):2534-44. [PubMed: 12562678]  [MGI Ref ID J:103018]

Krieglstein CF; Anthoni C; Cerwinka WH; Stokes KY; Russell J; Grisham MB; Granger DN. 2007. Role of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation. Am J Pathol 170(2):490-6. [PubMed: 17255317]  [MGI Ref ID J:117890]

Krieglstein CF; Cerwinka WH; Laroux FS; Salter JW; Russell JM; Schuermann G; Grisham MB; Ross CR; Granger DN. 2001. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194(9):1207-18. [PubMed: 11696587]  [MGI Ref ID J:134388]

Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. [PubMed: 11425775]  [MGI Ref ID J:103350]

Kummer MP; Hermes M; Delekarte A; Hammerschmidt T; Kumar S; Terwel D; Walter J; Pape HC; Konig S; Roeber S; Jessen F; Klockgether T; Korte M; Heneka MT. 2011. Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71(5):833-44. [PubMed: 21903077]  [MGI Ref ID J:176667]

Kurtz S; McKinnon KP; Runge MS; Ting JP; Braunstein M. 2006. The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response. Infect Immun 74(12):6855-64. [PubMed: 17030572]  [MGI Ref ID J:116072]

LaCasse CJ; Janikashvili N; Larmonier CB; Alizadeh D; Hanke N; Kartchner J; Situ E; Centuori S; Har-Noy M; Bonnotte B; Katsanis E; Larmonier N. 2011. Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-gamma-dependent mechanism. J Immunol 187(12):6310-7. [PubMed: 22075702]  [MGI Ref ID J:180408]

Lai JF; Zindl CL; Duffy LB; Atkinson TP; Jung YW; van Rooijen N; Waites KB; Krause DC; Chaplin DD. 2010. Critical role of macrophages and their activation via MyD88-NFkappaB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS One 5(12):e14417. [PubMed: 21203444]  [MGI Ref ID J:168336]

Lamon BD; Upmacis RK; Deeb RS; Koyuncu H; Hajjar DP. 2010. Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli. Am J Physiol Heart Circ Physiol 299(3):H613-23. [PubMed: 20543082]  [MGI Ref ID J:164511]

Landgraf RG; Russo M; Jancar S. 2005. Acute inhibition of inducible nitric oxide synthase but not its absence suppresses asthma-like responses. Eur J Pharmacol 518(2-3):212-20. [PubMed: 16023634]  [MGI Ref ID J:106361]

Laubach VE; Foley PL; Shockey KS; Tribble CG; Kron IL. 1998. Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol 275(6 Pt 2):H2211-8. [PubMed: 9843821]  [MGI Ref ID J:51564]

Laubach VE; Shesely EG; Smithies O; Sherman PA. 1995. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A 92(23):10688-92. [PubMed: 7479866]  [MGI Ref ID J:29677]

Leal EC; Manivannan A; Hosoya K; Terasaki T; Cunha-Vaz J; Ambrosio AF; Forrester JV. 2007. Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci 48(11):5257-65. [PubMed: 17962481]  [MGI Ref ID J:127155]

Lee MR; Seo GY; Kim YM; Kim PH. 2011. iNOS potentiates mouse Ig isotype switching through AID expression. Biochem Biophys Res Commun 410(3):602-7. [PubMed: 21684254]  [MGI Ref ID J:174949]

Lee YS; Li N; Shin S; Jun HS. 2009. Role of nitric oxide in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J Virol 83(16):8004-11. [PubMed: 19535454]  [MGI Ref ID J:151516]

Lefer DJ; Jones SP; Girod WG; Baines A; Grisham MB; Cockrell AS; Huang PL; Scalia R. 1999. Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice. Am J Physiol 276(6 Pt 2):H1943-50. [PubMed: 10362674]  [MGI Ref ID J:55936]

Lewis CJ; Cobb BA. 2010. Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling. J Immunol 184(7):3789-800. [PubMed: 20200279]  [MGI Ref ID J:160075]

Li D; Laubach VE; Johns RA. 2001. Upregulation of lung soluble guanylate cyclase during chronic hypoxia is prevented by deletion of eNOS. Am J Physiol Lung Cell Mol Physiol 281(2):L369-76. [PubMed: 11435211]  [MGI Ref ID J:108269]

Li D; Shin JH; Duan D. 2011. iNOS Ablation Does Not Improve Specific Force of the Extensor Digitorum Longus Muscle in Dystrophin-Deficient mdx4cv Mice. PLoS One 6(6):e21618. [PubMed: 21738735]  [MGI Ref ID J:174763]

Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. [PubMed: 16365445]  [MGI Ref ID J:126256]

Li G; Veenstra AA; Talahalli RR; Wang X; Gubitosi-Klug RA; Sheibani N; Kern TS. 2012. Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice. Diabetes 61(12):3294-303. [PubMed: 22923475]  [MGI Ref ID J:208497]

Li J; Baud O; Vartanian T; Volpe JJ; Rosenberg PA. 2005. Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes. Proc Natl Acad Sci U S A 102(28):9936-41. [PubMed: 15998743]  [MGI Ref ID J:99857]

Li W; Ren G; Huang Y; Su J; Han Y; Li J; Chen X; Cao K; Chen Q; Shou P; Zhang L; Yuan ZR; Roberts AI; Shi S; Le AD; Shi Y. 2012. Mesenchymal stem cells: a double-edged sword in regulating immune responses. Cell Death Differ 19(9):1505-13. [PubMed: 22421969]  [MGI Ref ID J:204801]

Li X; McKinstry KK; Swain SL; Dalton DK. 2007. IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179(2):939-49. [PubMed: 17617585]  [MGI Ref ID J:149401]

Liao S; Cheng G; Conner DA; Huang Y; Kucherlapati RS; Munn LL; Ruddle NH; Jain RK; Fukumura D; Padera TP. 2011. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A 108(46):18784-9. [PubMed: 22065738]  [MGI Ref ID J:180179]

Libby RT; Howell GR; Pang IH; Savinova OV; Mehalow AK; Barter JW; Smith RS; Clark AF; John SW. 2007. Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model. BMC Neurosci 8:108. [PubMed: 18093296]  [MGI Ref ID J:130816]

Liberatore GT; Jackson-Lewis V; Vukosavic S; Mandir AS; Vila M; McAuliffe WG; Dawson VL; Dawson TM; Przedborski S. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease [see comments] Nat Med 5(12):1403-9. [PubMed: 10581083]  [MGI Ref ID J:58724]

Lichten LA; Liuzzi JP; Cousins RJ. 2009. Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 296(4):G860-7. [PubMed: 19179618]  [MGI Ref ID J:149697]

Lidington D; Li F; Tyml K. 2007. Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle. Cardiovasc Res 74(1):151-8. [PubMed: 17258180]  [MGI Ref ID J:119500]

Lindgren H; Stenmark S; Chen W; Tarnvik A; Sjostedt A. 2004. Distinct roles of reactive nitrogen and oxygen species to control infection with the facultative intracellular bacterium Francisella tularensis. Infect Immun 72(12):7172-82. [PubMed: 15557642]  [MGI Ref ID J:94215]

Ling W; Zhang J; Yuan Z; Ren G; Zhang L; Chen X; Rabson AB; Roberts AI; Wang Y; Shi Y. 2014. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment. Cancer Res 74(5):1576-87. [PubMed: 24452999]  [MGI Ref ID J:208149]

Ling YM; Shaw MH; Ayala C; Coppens I; Taylor GA; Ferguson DJ; Yap GS. 2006. Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J Exp Med 203(9):2063-71. [PubMed: 16940170]  [MGI Ref ID J:124556]

Liu YH; Carretero OA; Cingolani OH; Liao TD; Sun Y; Xu J; Li LY; Pagano PJ; Yang JJ; Yang XP. 2005. Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol 289(6):H2616-23. [PubMed: 16055518]  [MGI Ref ID J:104749]

Lizarbe TR; Tarin C; Gomez M; Lavin B; Aracil E; Orte LM; Zaragoza C. 2009. Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN. Am J Pathol :. [PubMed: 19779140]  [MGI Ref ID J:152751]

Lu G; Zhang R; Geng S; Peng L; Jayaraman P; Chen C; Xu F; Yang J; Li Q; Zheng H; Shen K; Wang J; Liu X; Wang W; Zheng Z; Qi CF; Si C; He JC; Liu K; Lira SA; Sikora AG; Li L; Xiong H. 2015. Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun 6:6676. [PubMed: 25813085]  [MGI Ref ID J:221863]

Lue Y; Sinha Hikim AP; Wang C; Leung A; Swerdloff RS. 2003. Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice. Endocrinology 144(7):3092-100. [PubMed: 12810565]  [MGI Ref ID J:84347]

Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice. Am J Physiol Endocrinol Metab 288(6):E1258-64. [PubMed: 15644457]  [MGI Ref ID J:98378]

Luiking YC; Hallemeesch MM; Lamers WH; Deutz NE. 2005. The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice. Am J Physiol Renal Physiol 288(4):F816-22. [PubMed: 15547116]  [MGI Ref ID J:97198]

Lush CW; Cepinskas G; Sibbald WJ; Kvietys PR. 2001. Endothelial E- and P-selectin expression in iNOS- deficient mice exposed to polymicrobial sepsis. Am J Physiol Gastrointest Liver Physiol 280(2):G291-7. [PubMed: 11208553]  [MGI Ref ID J:68060]

Maa MC; Chang MY; Li J; Li YY; Hsieh MY; Yang CJ; Chen YJ; Li Y; Chen HC; Cheng WE; Hsieh CY; Cheng CW; Leu TH. 2011. The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages. Biochim Biophys Acta 1813(1):136-47. [PubMed: 20849883]  [MGI Ref ID J:170208]

Mahnke A; Meier RJ; Schatz V; Hofmann J; Castiglione K; Schleicher U; Wolfbeis OS; Bogdan C; Jantsch J. 2014. Hypoxia in Leishmania major Skin Lesions Impairs the NO-Dependent Leishmanicidal Activity of Macrophages. J Invest Dermatol 134(9):2339-46. [PubMed: 24583949]  [MGI Ref ID J:212841]

Malan D; Ji GJ; Schmidt A; Addicks K; Hescheler J; Levi RC; Bloch W; Fleischmann BK. 2004. Nitric oxide, a key signaling molecule in the murine early embryonic heart. FASEB J 18(10):1108-10. [PubMed: 15132985]  [MGI Ref ID J:118469]

Malik M; Jividen K; Padmakumar VC; Cataisson C; Li L; Lee J; Howard OM; Yuspa SH. 2012. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A 109(16):6130-5. [PubMed: 22474389]  [MGI Ref ID J:183611]

Marigo I; Bosio E; Solito S; Mesa C; Fernandez A; Dolcetti L; Ugel S; Sonda N; Bicciato S; Falisi E; Calabrese F; Basso G; Zanovello P; Cozzi E; Mandruzzato S; Bronte V. 2010. Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32(6):790-802. [PubMed: 20605485]  [MGI Ref ID J:162002]

Marjanovic JA; Stojanovic A; Brovkovych VM; Skidgel RA; Du X. 2008. Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation. J Biol Chem 283(43):28827-34. [PubMed: 18753139]  [MGI Ref ID J:142549]

Marriott HM; Hellewell PG; Cross SS; Ince PG; Whyte MK; Dockrell DH. 2006. Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia. J Immunol 177(9):6480-8. [PubMed: 17056580]  [MGI Ref ID J:140505]

Martin LJ; Chen K; Liu Z. 2005. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25(27):6449-59. [PubMed: 16000635]  [MGI Ref ID J:99428]

Mascia F; Lam G; Keith C; Garber C; Steinberg SM; Kohn E; Yuspa SH. 2013. Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci Transl Med 5(199):199ra110. [PubMed: 23966299]  [MGI Ref ID J:213463]

Mastroeni P; Vazquez-Torres A; Fang FC; Xu Y; Khan S; Hormaeche CE; Dougan G. 2000. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo. J Exp Med 192(2):237-48. [PubMed: 10899910]  [MGI Ref ID J:63489]

Mathe E; Nguyen GH; Funamizu N; He P; Moake M; Croce CM; Hussain SP. 2012. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. Int J Cancer 131(3):760-5. [PubMed: 22042537]  [MGI Ref ID J:186121]

Mayr U; Zou Y; Zhang Z; Dietrich H; Hu Y; Xu Q. 2006. Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair. Circ Res 98(3):412-20. [PubMed: 16385078]  [MGI Ref ID J:118879]

McKenna KC; Beatty KM; Scherder RC; Li F; Liu H; Chen AF; Ghosh A; Stuehr DJ. 2013. Ascorbate in aqueous humor augments nitric oxide production by macrophages. J Immunol 190(2):556-64. [PubMed: 23241881]  [MGI Ref ID J:191191]

McKim SE; Gabele E; Isayama F; Lambert JC; Tucker LM; Wheeler MD; Connor HD; Mason RP; Doll MA; Hein DW; Arteel GE. 2003. Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology 125(6):1834-44. [PubMed: 14724835]  [MGI Ref ID J:86852]

McKinnon RL; Lidington D; Bolon M; Ouellette Y; Kidder GM; Tyml K. 2006. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 69(1):236-44. [PubMed: 16226732]  [MGI Ref ID J:112791]

Merkel MJ; Liu L; Cao Z; Packwood W; Hurn PD; Van Winkle DM. 2008. Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes. Am J Physiol Heart Circ Physiol 295(1):H409-15. [PubMed: 18502904]  [MGI Ref ID J:138205]

Mestriner FL; Spiller F; Laure HJ; Souto FO; Tavares-Murta BM; Rosa JC; Basile-Filho A; Ferreira SH; Greene LJ; Cunha FQ. 2007. Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism. Proc Natl Acad Sci U S A 104(49):19595-600. [PubMed: 18048324]  [MGI Ref ID J:128489]

Mgbemena V; Segovia JA; Chang TH; Tsai SY; Cole GT; Hung CY; Bose S. 2012. Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol 189(2):606-15. [PubMed: 22711891]  [MGI Ref ID J:189798]

Michael SL; Mayeux PR; Bucci TJ; Warbritton AR; Irwin LK; Pumford NR; Hinson JA. 2001. Acetaminophen-induced hepatotoxicity in mice lacking inducible nitric oxide synthase activity. Nitric Oxide 5(5):432-41. [PubMed: 11587558]  [MGI Ref ID J:72352]

Miguel RD; Cherpes TL; Watson LJ; McKenna KC. 2010. CTL Induction of Tumoricidal Nitric Oxide Production by Intratumoral Macrophages Is Critical for Tumor Elimination. J Immunol 185(11):6706-18. [PubMed: 21041723]  [MGI Ref ID J:166136]

Mishra BB; Rathinam VA; Martens GW; Martinot AJ; Kornfeld H; Fitzgerald KA; Sassetti CM. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1beta. Nat Immunol 14(1):52-60. [PubMed: 23160153]  [MGI Ref ID J:191074]

Mittal R; Gonzalez-Gomez I; Goth KA; Prasadarao NV. 2010. Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis. Am J Pathol 176(3):1292-305. [PubMed: 20093483]  [MGI Ref ID J:158359]

Miyazawa M; Suzuki H; Masaoka T; Kai A; Suematsu M; Nagata H; Miura S; Ishii H. 2003. Suppressed apoptosis in the inflamed gastric mucosa of Helicobacter pylori-colonized iNOS-knockout mice. Free Radic Biol Med 34(12):1621-30. [PubMed: 12788482]  [MGI Ref ID J:119415]

Moayeri M; Crown D; Newman ZL; Okugawa S; Eckhaus M; Cataisson C; Liu S; Sastalla I; Leppla SH. 2010. Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment. PLoS Pathog 6(12):e1001222. [PubMed: 21170303]  [MGI Ref ID J:168096]

Moayeri M; Martinez NW; Wiggins J; Young HA; Leppla SH. 2004. Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity. Infect Immun 72(8):4439-47. [PubMed: 15271901]  [MGI Ref ID J:91775]

Moens AL; Leyton-Mange JS; Niu X; Yang R; Cingolani O; Arkenbout EK; Champion HC; Bedja D; Gabrielson KL; Chen J; Xia Y; Hale AB; Channon KM; Halushka MK; Barker N; Wuyts FL; Kaminski PM; Wolin MS; Kass DA; Barouch LA. 2009. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol 47(5):576-85. [PubMed: 19766235]  [MGI Ref ID J:155006]

Montezuma K; Biojone C; Lisboa SF; Cunha FQ; Guimaraes FS; Joca SR. 2012. Inhibition of iNOS induces antidepressant-like effects in mice: pharmacological and genetic evidence. Neuropharmacology 62(1):485-91. [PubMed: 21939674]  [MGI Ref ID J:183566]

Moore ZW; Hui DY. 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46(10):2083-90. [PubMed: 16061951]  [MGI Ref ID J:104724]

Moraes JC; Amaral ME; Picardi PK; Calegari VC; Romanatto T; Bermudez-Echeverry M; Chiavegatto S; Saad MJ; Velloso LA. 2006. Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 580(19):4625-31. [PubMed: 16876161]  [MGI Ref ID J:112153]

Morton J; Coles B; Wright K; Gallimore A; Morrow JD; Terry ES; Anning PB; Morgan BP; Dioszeghy V; Kuhn H; Chaitidis P; Hobbs AJ; Jones SA; O'Donnell VB. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice. Blood 111(10):5187-94. [PubMed: 18281503]  [MGI Ref ID J:135580]

Mota BE; Gallardo-Romero N; Trindade G; Keckler MS; Karem K; Carroll D; Campos MA; Vieira LQ; da Fonseca FG; Ferreira PC; Bonjardim CA; Damon IK; Kroon EG. 2011. Adverse Events Post Smallpox-Vaccination: Insights from Tail Scarification Infection in Mice with Vaccinia virus. PLoS One 6(4):e18924. [PubMed: 21526210]  [MGI Ref ID J:172270]

Myers L; Croft M; Kwon BS; Mittler RS; Vella AT. 2005. Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression. J Immunol 174(12):7625-32. [PubMed: 15944263]  [MGI Ref ID J:100786]

Naghashpour M; Dahl G. 2000. Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus. Biol Reprod 63(5):1421-7. [PubMed: 11058547]  [MGI Ref ID J:108667]

Nam KT; Oh SY; Ahn B; Kim YB; Jang DD; Yang KH; Hahm KB; Kim DY. 2004. Decreased Helicobacter pylori associated gastric carcinogenesis in mice lacking inducible nitric oxide synthase. Gut 53(9):1250-5. [PubMed: 15306579]  [MGI Ref ID J:92904]

Naura AS; Zerfaoui M; Kim H; Abd Elmageed ZY; Rodriguez PC; Hans CP; Ju J; Errami Y; Park J; Ochoa AC; Boulares AH. 2010. Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation. J Immunol 185(5):3076-85. [PubMed: 20668217]  [MGI Ref ID J:163265]

Nemeth K; Leelahavanichkul A; Yuen PS; Mayer B; Parmelee A; Doi K; Robey PG; Leelahavanichkul K; Koller BH; Brown JM; Hu X; Jelinek I; Star RA; Mezey E. 2009. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42-9. [PubMed: 19098906]  [MGI Ref ID J:146566]

Niedbala W; Alves-Filho JC; Fukada SY; Vieira SM; Mitani A; Sonego F; Mirchandani A; Nascimento DC; Cunha FQ; Liew FY. 2011. Regulation of type 17 helper T-cell function by nitric oxide during inflammation. Proc Natl Acad Sci U S A 108(22):9220-5. [PubMed: 21576463]  [MGI Ref ID J:173232]

Nishida M; Ogushi M; Suda R; Toyotaka M; Saiki S; Kitajima N; Nakaya M; Kim KM; Ide T; Sato Y; Inoue K; Kurose H. 2011. Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-{kappa}B. Proc Natl Acad Sci U S A 108(16):6662-7. [PubMed: 21464294]  [MGI Ref ID J:171373]

Nishikawa M; Chang B; Inoue M. 2004. Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors. Carcinogenesis 25(11):2101-5. [PubMed: 15205363]  [MGI Ref ID J:93780]

Njoku C; Self SE; Ruiz P; Hofbauer AF; Gilkeson GS; Oates JC. 2008. Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene. J Investig Med 56(7):911-9. [PubMed: 18797415]  [MGI Ref ID J:205256]

Noh HS; Kim DW; Cho GJ; Choi WS; Kang SS. 2006. Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice. Brain Res 1075(1):193-200. [PubMed: 16460714]  [MGI Ref ID J:107300]

Norman MU; Zbytnuik L; Kubes P. 2008. Interferon-gamma limits Th1 lymphocyte adhesion to inflamed endothelium: A nitric oxide regulatory feedback mechanism. Eur J Immunol 38(5):1368-80. [PubMed: 18412158]  [MGI Ref ID J:134151]

Noronha BT; Li JM; Wheatcroft SB; Shah AM; Kearney MT. 2005. Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity. Diabetes 54(4):1082-9. [PubMed: 15793247]  [MGI Ref ID J:105205]

O'Connor RA; Wittmer S; Dalton DK. 2005. Infection-induced apoptosis deletes bystander CD4(+) T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24(2):93-100. [PubMed: 15829401]  [MGI Ref ID J:97542]

Okayama H; Saito M; Oue N; Weiss JM; Stauffer J; Takenoshita S; Wiltrout RH; Hussain SP; Harris CC. 2013. NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression. Int J Cancer 132(1):9-18. [PubMed: 22618808]  [MGI Ref ID J:191775]

Olson N; Greul AK; Hristova M; Bove PF; Kasahara DI; van der Vliet A. 2009. Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability. Arch Biochem Biophys 484(2):205-13. [PubMed: 19100237]  [MGI Ref ID J:150975]

Olson N; Kasahara DI; Hristova M; Bernstein R; Janssen-Heininger Y; van der Vliet A. 2011. Modulation of NF-kappaB and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol 44(6):813-23. [PubMed: 20693401]  [MGI Ref ID J:185029]

Ono K; Suzuki H; Sawada M. 2010. Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Neurosci Lett 473(2):146-50. [PubMed: 20178828]  [MGI Ref ID J:159909]

Parathath SR; Gravanis I; Tsirka SE. 2007. Nitric oxide synthase isoforms undertake unique roles during excitotoxicity. Stroke 38(6):1938-45. [PubMed: 17446423]  [MGI Ref ID J:150557]

Parekh VV; Wu L; Olivares-Villagomez D; Wilson KT; Van Kaer L. 2013. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J Immunol 190(5):1948-60. [PubMed: 23345328]  [MGI Ref ID J:193488]

Parent MA; Wilhelm LB; Kummer LW; Szaba FM; Mullarky IK; Smiley ST. 2006. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection. Infect Immun 74(6):3381-6. [PubMed: 16714568]  [MGI Ref ID J:109236]

Park KM; Byun JY; Kramers C; Kim JI; Huang PL; Bonventre JV. 2003. Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney. J Biol Chem 278(29):27256-66. [PubMed: 12682064]  [MGI Ref ID J:120673]

Park KM; Kim JI; Ahn Y; Bonventre AJ; Bonventre JV. 2004. Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem 279(50):52282-92. [PubMed: 15358759]  [MGI Ref ID J:95182]

Park YH; Shin HJ; Kim SU; Kim JM; Kim JH; Bang DH; Chang KT; Kim BY; Yu DY. 2013. iNOS promotes HBx-induced hepatocellular carcinoma via upregulation of JNK activation. Biochem Biophys Res Commun 435(2):244-9. [PubMed: 23643810]  [MGI Ref ID J:201929]

Pascual O; Ben Achour S; Rostaing P; Triller A; Bessis A. 2012. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A 109(4):E197-205. [PubMed: 22167804]  [MGI Ref ID J:180137]

Pearl JE; Torrado E; Tighe M; Fountain JJ; Solache A; Strutt T; Swain S; Appelberg R; Cooper AM. 2012. Nitric oxide inhibits the accumulation of CD4(+) CD44(hi) Tbet(+) CD69(lo) T cells in mycobacterial infection. Eur J Immunol 42(12):3267-79. [PubMed: 22890814]  [MGI Ref ID J:190236]

Peng X; Abdulnour RE; Sammani S; Ma SF; Han EJ; Hasan EJ; Tuder R; Garcia JG; Hassoun PM. 2005. Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med 172(4):470-9. [PubMed: 15937288]  [MGI Ref ID J:114335]

Perreault M; Marette A. 2001. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-43. [PubMed: 11590438]  [MGI Ref ID J:72215]

Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612]  [MGI Ref ID J:122702]

Pol O; Sasaki M; Jimenez N; Dawson VL; Dawson TM; Puig MM. 2005. The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice. Br J Pharmacol 145(6):758-66. [PubMed: 15852037]  [MGI Ref ID J:114344]

Poljakovic M; Persson K. 2003. Urinary tract infection in iNOS-deficient mice with focus on bacterial sensitivity to nitric oxide. Am J Physiol Renal Physiol 284(1):F22-31. [PubMed: 12494944]  [MGI Ref ID J:127929]

Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. [PubMed: 19465644]  [MGI Ref ID J:148912]

Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. [PubMed: 22044243]  [MGI Ref ID J:181390]

Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. [PubMed: 21518784]  [MGI Ref ID J:173486]

Predescu D; Predescu S; Shimizu J; Miyawaki-Shimizu K; Malik AB. 2005. Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol 289(3):L371-81. [PubMed: 16093363]  [MGI Ref ID J:115733]

Pullamsetti SS; Savai R; Dumitrascu R; Dahal BK; Wilhelm J; Konigshoff M; Zakrzewicz D; Ghofrani HA; Weissmann N; Eickelberg O; Guenther A; Leiper J; Seeger W; Grimminger F; Schermuly RT. 2011. The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med 3(87):87ra53. [PubMed: 21677199]  [MGI Ref ID J:173535]

Qiu H; Kuolee R; Harris G; Chen W. 2009. Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice. Infect Immun 77(3):1015-21. [PubMed: 19103777]  [MGI Ref ID J:145717]

Raghuvanshi S; Sharma P; Singh S; Van Kaer L; Das G. 2010. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proc Natl Acad Sci U S A :. [PubMed: 21135221]  [MGI Ref ID J:167304]

Reece ST; Loddenkemper C; Askew DJ; Zedler U; Schommer-Leitner S; Stein M; Mir FA; Dorhoi A; Mollenkopf HJ; Silverman GA; Kaufmann SH. 2010. Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice. J Clin Invest 120(9):3365-76. [PubMed: 20679732]  [MGI Ref ID J:165286]

Reho JJ; Zheng X; Asico LD; Fisher SA. 2015. Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis. Am J Physiol Heart Circ Physiol 308(9):H1039-50. [PubMed: 25724497]  [MGI Ref ID J:222122]

Ren G; Su J; Zhao X; Zhang L; Zhang J; Roberts AI; Zhang H; Das G; Shi Y. 2008. Apoptotic cells induce immunosuppression through dendritic cells: critical roles of IFN-gamma and nitric oxide. J Immunol 181(5):3277-84. [PubMed: 18713999]  [MGI Ref ID J:138951]

Reynolds CM; Suliman HB; Hollingsworth JW; Welty-Wolf KE; Carraway MS; Piantadosi CA. 2009. Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radic Biol Med 46(5):564-72. [PubMed: 19073249]  [MGI Ref ID J:145176]

Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. [PubMed: 23016931]  [MGI Ref ID J:190735]

Rigamonti E; Touvier T; Clementi E; Manfredi AA; Brunelli S; Rovere-Querini P. 2013. Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol 190(4):1767-77. [PubMed: 23335752]  [MGI Ref ID J:193495]

Rivera J; Mukherjee J; Weiss LM; Casadevall A. 2002. Antibody Efficacy in Murine Pulmonary Cryptococcus neoformans Infection: A Role for Nitric Oxide. J Immunol 168(7):3419-27. [PubMed: 11907100]  [MGI Ref ID J:75578]

Rocha FJ; Schleicher U; Mattner J; Alber G; Bogdan C. 2007. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect Immun 75(8):3823-32. [PubMed: 17517868]  [MGI Ref ID J:123377]

Ropelle ER; Pauli JR; Cintra DE; da Silva AS; De Souza CT; Guadagnini D; Carvalho BM; Caricilli AM; Katashima CK; Carvalho-Filho MA; Hirabara S; Curi R; Velloso LA; Saad MJ; Carvalheira JB. 2013. Targeted disruption of inducible nitric oxide synthase protects against aging, S-nitrosation, and insulin resistance in muscle of male mice. Diabetes 62(2):466-70. [PubMed: 22991447]  [MGI Ref ID J:208474]

Rosypal AC; Lindsay DS; Duncan R Jr; Ahmed SA; Zajac AM; Dubey JP. 2002. Mice lacking the gene for inducible or endothelial nitric oxide are resistant to sporocyst induced Sarcocystis neurona infections. Vet Parasitol 103(4):315-21. [PubMed: 11777610]  [MGI Ref ID J:106322]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Rudkowski JC; Barreiro E; Harfouche R; Goldberg P; Kishta O; D'Orleans-Juste P; Labonte J; Lesur O; Hussain SN. 2004. Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis. Am J Physiol Lung Cell Mol Physiol 286(4):L793-800. [PubMed: 14660484]  [MGI Ref ID J:108149]

Russell MS; Dudani R; Krishnan L; Sad S. 2009. IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells. J Immunol 183(12):7710-8. [PubMed: 19923462]  [MGI Ref ID J:157498]

Saini AS; Shenoy GN; Rath S; Bal V; George A. 2014. Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells. Nat Immunol 15(3):275-82. [PubMed: 24441790]  [MGI Ref ID J:209367]

Sam F; Sawyer DB; Xie Z; Chang DL; Ngoy S; Brenner DA; Siwik DA; Singh K; Apstein CS; Colucci WS. 2001. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res 89(4):351-6. [PubMed: 11509452]  [MGI Ref ID J:115413]

Saraswathy S; Nguyen AM; Rao NA. 2010. The role of TLR4 in photoreceptor {alpha}a crystallin upregulation during early experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 51(7):3680-6. [PubMed: 20207969]  [MGI Ref ID J:164096]

Sato K; Ozaki K; Oh I; Meguro A; Hatanaka K; Nagai T; Muroi K; Ozawa K. 2007. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109(1):228-34. [PubMed: 16985180]  [MGI Ref ID J:142176]

Scallan JP; Davis MJ. 2013. Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels. J Physiol 591(Pt 8):2139-56. [PubMed: 23420659]  [MGI Ref ID J:208101]

Scanga CA; Mohan VP; Tanaka K; Alland D; Flynn JL; Chan J. 2001. The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice. Infect Immun 69(12):7711-7. [PubMed: 11705952]  [MGI Ref ID J:73135]

Scott DJ; Hull MA; Cartwright EJ; Lam WK; Tisbury A; Poulsom R; Markham AF; Bonifer C; Coletta PL. 2001. Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology 121(4):889-99. [PubMed: 11606502]  [MGI Ref ID J:72030]

Seimetz M; Parajuli N; Pichl A; Veit F; Kwapiszewska G; Weisel FC; Milger K; Egemnazarov B; Turowska A; Fuchs B; Nikam S; Roth M; Sydykov A; Medebach T; Klepetko W; Jaksch P; Dumitrascu R; Garn H; Voswinckel R; Kostin S; Seeger W; Schermuly RT; Grimminger F; Ghofrani HA; Weissmann N. 2011. Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice. Cell 147(2):293-305. [PubMed: 22000010]  [MGI Ref ID J:177505]

Sercan O; Hammerling GJ; Arnold B; Schuler T. 2006. Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis. J Immunol 176(2):735-9. [PubMed: 16393956]  [MGI Ref ID J:126599]

Seril DN; Liao J; Yang GY. 2007. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog 46(5):341-53. [PubMed: 17219424]  [MGI Ref ID J:121634]

Shesely EG; Gilbert C; Granderson G; Carretero CD; Carretero OA; Beierwaltes WH. 2001. Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy. Am J Obstet Gynecol 185(5):1198-203. [PubMed: 11717657]  [MGI Ref ID J:117212]

Shesely EG; Maeda N; Kim HS; Desai KM; Krege JH; Laubach VE; Sherman PA; Sessa WC; Smithies O. 1996. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 93(23):13176-81. [PubMed: 8917564]  [MGI Ref ID J:36559]

Shie FS; Montine KS; Breyer RM; Montine TJ. 2005. Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 52(1):70-7. [PubMed: 15920732]  [MGI Ref ID J:156154]

Shimazu T; Otani H; Yoshioka K; Fujita M; Okazaki T; Iwasaka T. 2011. Sepiapterin enhances angiogenesis and functional recovery in mice after myocardial infarction. Am J Physiol Heart Circ Physiol 301(5):H2061-72. [PubMed: 21890687]  [MGI Ref ID J:178332]

Shin HJ; Park YH; Kim SU; Moon HB; Park do S; Han YH; Lee CH; Lee DS; Song IS; Lee DH; Kim M; Kim NS; Kim DG; Kim JM; Kim SK; Kim YN; Kim SS; Choi CS; Kim YB; Yu DY. 2011. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem 286(34):29872-81. [PubMed: 21690090]  [MGI Ref ID J:176632]

Simmons CP; Goncalves NS; Ghaem-Maghami M; Bajaj-Elliott M; Clare S; Neves B; Frankel G; Dougan G; MacDonald TT. 2002. Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma. J Immunol 168(4):1804-12. [PubMed: 11823513]  [MGI Ref ID J:74480]

Somers JR; Beck PL; Lees-Miller JP; Roach D; Li Y; Guo J; Loken S; Zhan S; Semeniuk L; Duff HJ. 2008. iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin. Am J Physiol Heart Circ Physiol 295(3):H1122-H1131. [PubMed: 18621856]  [MGI Ref ID J:141285]

Speyer CL; Neff TA; Warner RL; Guo RF; Sarma JV; Riedemann NC; Murphy ME; Murphy HS; Ward PA. 2003. Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol 163(6):2319-28. [PubMed: 14633605]  [MGI Ref ID J:86598]

Spohr F; Cornelissen AJ; Busch C; Gebhard MM; Motsch J; Martin EO; Weimann J. 2005. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 289(2):H823-31. [PubMed: 15778287]  [MGI Ref ID J:100323]

Stadler K; Bonini MG; Dallas S; Duma D; Mason RP; Kadiiska MB. 2008. Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab 295(2):E456-62. [PubMed: 18559982]  [MGI Ref ID J:139996]

Steed MM; Tyagi N; Sen U; Schuschke DA; Joshua IG; Tyagi SC. 2010. Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice. Am J Physiol Lung Cell Mol Physiol 299(3):L301-11. [PubMed: 20581102]  [MGI Ref ID J:164613]

Streifel KM; Moreno JA; Hanneman WH; Legare ME; Tjalkens RB. 2012. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicol Sci 126(1):183-92. [PubMed: 22174044]  [MGI Ref ID J:183641]

Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. [PubMed: 16148148]  [MGI Ref ID J:116703]

Sugimura Y; Murase T; Oyama K; Uchida A; Sato N; Hayasaka S; Kano Y; Takagishi Y; Hayashi Y; Oiso Y; Murata Y. 2009. Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia 52(5):962-71. [PubMed: 19283362]  [MGI Ref ID J:148113]

Sugita H; Fujimoto M; Yasukawa T; Shimizu N; Sugita M; Yasuhara S; Martyn JA; Kaneki M. 2005. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280(14):14203-11. [PubMed: 15805118]  [MGI Ref ID J:98746]

Suliman HB; Babiker A; Withers CM; Sweeney TE; Carraway MS; Tatro LG; Bartz RR; Welty-Wolf KE; Piantadosi CA. 2010. Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. Free Radic Biol Med 48(5):736-46. [PubMed: 20043987]  [MGI Ref ID J:157083]

Sun K; Gan Y; Metzger DW. 2011. Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract. Infect Immun 79(5):1842-7. [PubMed: 21321074]  [MGI Ref ID J:171962]

Sunil VR; Shen J; Patel-Vayas K; Gow AJ; Laskin JD; Laskin DL. 2012. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. Toxicol Appl Pharmacol 261(1):22-30. [PubMed: 22446026]  [MGI Ref ID J:186088]

Suvorava T; Stegbauer J; Thieme M; Pick S; Friedrich S; Rump LC; Hohlfeld T; Kojda G. 2015. Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice. Biochem Biophys Res Commun 458(3):576-83. [PubMed: 25680465]  [MGI Ref ID J:220487]

Tangpong J; Sompol P; Vore M; St Clair W; Butterfield DA; St Clair DK. 2008. Tumor necrosis factor alpha-mediated nitric oxide production enhances manganese superoxide dismutase nitration and mitochondrial dysfunction in primary neurons: an insight into the role of glial cells. Neuroscience 151(2):622-9. [PubMed: 18160224]  [MGI Ref ID J:130957]

Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M. 2011. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. J Biol Chem 286(33):29388-96. [PubMed: 21700708]  [MGI Ref ID J:175918]

Tao F; Tao YX; Mao P; Zhao C; Li D; Liaw WJ; Raja SN; Johns RA. 2003. Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3):847-54. [PubMed: 12895524]  [MGI Ref ID J:126175]

Tarin C; Lavin B; Gomez M; Saura M; Diez-Juan A; Zaragoza C. 2011. The extracellular matrix metalloproteinase inducer EMMPRIN is a target of nitric oxide in myocardial ischemia/reperfusion. Free Radic Biol Med 51(2):387-95. [PubMed: 21570464]  [MGI Ref ID J:174100]

Tatemichi M; Ogura T; Sakurazawa N; Nagata H; Sugita M; Esumi H. 2003. Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers. Int J Exp Pathol 84(5):213-20. [PubMed: 14690480]  [MGI Ref ID J:87317]

Tavener SA; Kubes P. 2006. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol 290(2):H800-6. [PubMed: 16172157]  [MGI Ref ID J:106721]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Theodorakis NG; Wang YN; Skill NJ; Metz MA; Cahill PA; Redmond EM; Sitzmann JV. 2003. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Gastroenterology 124(5):1500-8. [PubMed: 12730888]  [MGI Ref ID J:107756]

Thoeni G; Stoitzner P; Brandacher G; Romani N; Heufler C; Werner-Felmayer G; Werner ER. 2005. Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase. J Immunol 174(12):7584-91. [PubMed: 15944258]  [MGI Ref ID J:100788]

Tranguch S; Huet-Hudson Y. 2003. Decreased viability of nitric oxide synthase double knockout mice. Mol Reprod Dev 65(2):175-9. [PubMed: 12704728]  [MGI Ref ID J:83112]

Tsui AK; Marsden PA; Mazer CD; Adamson SL; Henkelman RM; Ho JJ; Wilson DF; Heximer SP; Connelly KA; Bolz SS; Lidington D; El-Beheiry MH; Dattani ND; Chen KM; Hare GM. 2011. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc Natl Acad Sci U S A 108(42):17544-9. [PubMed: 21976486]  [MGI Ref ID J:177441]

Uemura T; Stringer DE; Blohm-Mangone KA; Gerner EW. 2010. Polyamine transport is mediated by both endocytic and solute carrier transport mechanisms in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol 299(2):G517-22. [PubMed: 20522643]  [MGI Ref ID J:163345]

Ullrich R; Bloch KD; Ichinose F; Steudel W; Zapol WM. 1999. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 104(10):1421-9. [PubMed: 10562304]  [MGI Ref ID J:58501]

Uppington H; Menager N; Boross P; Wood J; Sheppard M; Verbeek S; Mastroeni P. 2006. Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages. Immunology 119(2):147-58. [PubMed: 16836651]  [MGI Ref ID J:118526]

Vareniuk I; Pavlov IA; Obrosova IG. 2008. Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes. Diabetologia 51(11):2126-33. [PubMed: 18802679]  [MGI Ref ID J:142727]

Velez CD; Lewis CJ; Kasper DL; Cobb BA. 2009. Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation. Immunology 127(1):73-82. [PubMed: 18778282]  [MGI Ref ID J:155663]

Vig M; Srivastava S; Kandpal U; Sade H; Lewis V; Sarin A; George A; Bal V; Durdik JM; Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. J Clin Invest 113(12):1734-42. [PubMed: 15199408]  [MGI Ref ID J:90903]

Villalta SA; Nguyen HX; Deng B; Gotoh T; Tidball JG. 2009. Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy. Hum Mol Genet 18(3):482-96. [PubMed: 18996917]  [MGI Ref ID J:143545]

Vishwakarma V; Pati NB; Chandel HS; Sahoo SS; Saha B; Suar M. 2012. Evaluation of Salmonella enterica serovar Typhimurium TTSS-2 deficient fur mutant as safe live-attenuated vaccine candidate for immunocompromised mice. PLoS One 7(12):e52043. [PubMed: 23284865]  [MGI Ref ID J:195626]

Vissers YL; Hallemeesch MM; Soeters PB; Lamers WH; Deutz NE. 2004. NOS2 deficiency increases intestinal metabolism both in nonstimulated and endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 286(5):G747-51. [PubMed: 14656712]  [MGI Ref ID J:95679]

Wang L; Mehta S; Gillis C; Law C; Taneja R. 2010. Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase. Biochem Biophys Res Commun 401(2):207-12. [PubMed: 20833133]  [MGI Ref ID J:165852]

Wang LF; Mehta S; Weicker S; Scott JA; Joseph M; Razavi HM; McCormack DG. 2001. Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (inos) activity in murine endotoxemia. Biochem Biophys Res Commun 283(3):694-9. [PubMed: 11341781]  [MGI Ref ID J:114281]

Wang T. 2002. Role of iNOS and eNOS in modulating proximal tubule transport and acid-base balance. Am J Physiol Renal Physiol 283(4):F658-62. [PubMed: 12217856]  [MGI Ref ID J:113614]

Wang T; Inglis FM; Kalb RG. 2000. Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. Am J Physiol Renal Physiol 279(3):F518-24. [PubMed: 10966931]  [MGI Ref ID J:64896]

Watanuki M; Sakai A; Sakata T; Tsurukami H; Miwa M; Uchida Y; Watanabe K; Ikeda K; Nakamura T. 2002. Role of inducible nitric oxide synthase in skeletal adaptation to acute increases in mechanical loading. J Bone Miner Res 17(6):1015-25. [PubMed: 12054156]  [MGI Ref ID J:112399]

Weberpals M; Hermes M; Hermann S; Kummer MP; Terwel D; Semmler A; Berger M; Schafers M; Heneka MT. 2009. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 29(45):14177-84. [PubMed: 19906966]  [MGI Ref ID J:154742]

Wei W; Li B; Hanes MA; Kakar S; Chen X; Liu L. 2010. S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med 2(19):19ra13. [PubMed: 20371487]  [MGI Ref ID J:167883]

Wei W; Yang Z; Tang CH; Liu L. 2011. Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O6-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine. Carcinogenesis 32(7):973-7. [PubMed: 21385828]  [MGI Ref ID J:173666]

White JK; Mastroeni P; Popoff JF; Evans CA; Blackwell JM. 2005. Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol 77(3):311-20. [PubMed: 15601666]  [MGI Ref ID J:97453]

Whiteus C; Freitas C; Grutzendler J. 2014. Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period. Nature 505(7483):407-11. [PubMed: 24305053]  [MGI Ref ID J:207919]

Wiese M; Gerlach RG; Popp I; Matuszak J; Mahapatro M; Castiglione K; Chakravortty D; Willam C; Hensel M; Bogdan C; Jantsch J. 2012. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun 80(4):1455-66. [PubMed: 22252868]  [MGI Ref ID J:182549]

Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. [PubMed: 19553436]  [MGI Ref ID J:150418]

Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. [PubMed: 18272675]  [MGI Ref ID J:132221]

Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. [PubMed: 19356689]  [MGI Ref ID J:148938]

Winter SE; Winter MG; Xavier MN; Thiennimitr P; Poon V; Keestra AM; Laughlin RC; Gomez G; Wu J; Lawhon SD; Popova IE; Parikh SJ; Adams LG; Tsolis RM; Stewart VJ; Baumler AJ. 2013. Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science 339(6120):708-11. [PubMed: 23393266]  [MGI Ref ID J:193601]

Wipke BT; Allen PM. 2001. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 167(3):1601-8. [PubMed: 11466382]  [MGI Ref ID J:120467]

Wood KC; Hebbel RP; Lefer DJ; Granger DN. 2006. Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction. Free Radic Biol Med 40(8):1443-53. [PubMed: 16631534]  [MGI Ref ID J:108238]

Wu D; Xu C; Cederbaum A. 2009. Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice. Free Radic Biol Med 46(4):480-91. [PubMed: 19063961]  [MGI Ref ID J:145179]

Wuthrich M; Filutowicz HI; Warner T; Klein BS. 2002. Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts. J Immunol 169(12):6969-76. [PubMed: 12471131]  [MGI Ref ID J:118419]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice. Circulation 99(16):2157-63. [PubMed: 10217657]  [MGI Ref ID J:54841]

Xi L; Jarrett NC; Hess ML; Kukreja RC. 1999. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice. Life Sci 65(9):935-45. [PubMed: 10465353]  [MGI Ref ID J:57432]

Xu G; Zhang Y; Zhang L; Ren G; Shi Y. 2008. Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide. Biochem Biophys Res Commun 375(4):666-70. [PubMed: 18755151]  [MGI Ref ID J:140996]

Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. [PubMed: 21576322]  [MGI Ref ID J:175272]

Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. [PubMed: 17982083]  [MGI Ref ID J:154010]

Yang JZ; Ajonuma LC; Rowlands DK; Tsang LL; Ho LS; Lam SY; Chen WY; Zhou CX; Chung YW; Cho CY; Tse JY; James AE; Chan HC. 2005. The role of inducible nitric oxide synthase in gamete interaction and fertilization: a comparative study on knockout mice of three NOS isoforms. Cell Biol Int 29(9):785-91. [PubMed: 16087361]  [MGI Ref ID J:112824]

Yang S; Porter VA; Cornfield DN; Milla C; Panoskaltsis-Mortari A; Blazar BR; Haddad IY. 2001. Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation. Am J Physiol Lung Cell Mol Physiol 281(4):L922-30. [PubMed: 11557596]  [MGI Ref ID J:72096]

Yang Z; Huang YC; Koziel H; de Crom R; Ruetten H; Wohlfart P; Thomsen RW; Kahlert JA; Sorensen HT; Jozefowski S; Colby A; Kobzik L. 2014. Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife 3:. [PubMed: 25317947]  [MGI Ref ID J:218028]

Yang Z; Wang ZE; Doulias PT; Wei W; Ischiropoulos H; Locksley RM; Liu L. 2010. Lymphocyte Development Requires S-nitrosoglutathione Reductase. J Immunol 185(11):6664-9. [PubMed: 20980633]  [MGI Ref ID J:166150]

Yerushalmi HF; Besselsen DG; Ignatenko NA; Blohm-Mangone KA; Padilla-Torres JL; Stringer DE; Cui H; Holubec H; Payne CM; Gerner EW. 2006. The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis. Mol Carcinog 45(2):93-105. [PubMed: 16329147]  [MGI Ref ID J:107079]

Yook YH; Kang KH; Maeng O; Kim TR; Lee JO; Kang KI; Kim YS; Paik SG; Lee H. 2004. Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochem Biophys Res Commun 321(2):298-305. [PubMed: 15358175]  [MGI Ref ID J:91305]

Zaki MH; Fujii S; Okamoto T; Islam S; Khan S; Ahmed KA; Sawa T; Akaike T. 2009. Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis. J Immunol 182(6):3746-56. [PubMed: 19265153]  [MGI Ref ID J:145919]

Zaragoza C; Lopez-Rivera E; Garcia-Rama C; Saura M; Martinez-Ruiz A; Lizarbe TR; Martin-de-Lara F; Lamas S. 2006. Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts. J Cell Sci 119(Pt 9):1896-902. [PubMed: 16636074]  [MGI Ref ID J:108930]

Zaragoza C; Ocampo CJ; Saura M; Bao C; Leppo M; Lafond-Walker A; Thiemann DR; Hruban R; Lowenstein CJ. 1999. Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163(10):5497-504. [PubMed: 10553076]  [MGI Ref ID J:58451]

Zeidler PC; Millecchia LM; Castranova V. 2004. Role of inducible nitric oxide synthase-derived nitric oxide in lipopolysaccharide plus interferon-gamma-induced pulmonary inflammation. Toxicol Appl Pharmacol 195(1):45-54. [PubMed: 14962504]  [MGI Ref ID J:87978]

Zelickson BR; Benavides GA; Johnson MS; Chacko BK; Venkatraman A; Landar A; Betancourt AM; Bailey SM; Darley-Usmar VM. 2011. Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes. Biochim Biophys Acta 1807(12):1573-82. [PubMed: 21971515]  [MGI Ref ID J:180333]

Zell JA; Ignatenko NA; Yerushalmi HF; Ziogas A; Besselsen DG; Gerner EW; Anton-Culver H. 2007. Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival. Int J Cancer 120(3):459-68. [PubMed: 17096347]  [MGI Ref ID J:117825]

Zhang P; Xu X; Hu X; van Deel ED; Zhu G; Chen Y. 2007. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res 100(7):1089-98. [PubMed: 17363700]  [MGI Ref ID J:133913]

Zhao T; Xi L; Chelliah J; Levasseur JE; Kukreja RC. 2000. Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 102(8):902-7. [PubMed: 10952960]  [MGI Ref ID J:103302]

Zhao TC; Zhang L; Liu JT; Guo TL. 2012. Disruption of Nox2 and TNFRp55/p75 eliminates cardioprotection induced by anisomycin. Am J Physiol Heart Circ Physiol 303(10):H1263-72. [PubMed: 22982779]  [MGI Ref ID J:191277]

Zhao Y; Ferguson DJ; Wilson DC; Howard JC; Sibley LD; Yap GS. 2009. Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages. J Immunol 182(6):3775-81. [PubMed: 19265156]  [MGI Ref ID J:145916]

Zhou J; Dehne N; Brune B. 2009. Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1. Free Radic Biol Med 47(6):741-9. [PubMed: 19523512]  [MGI Ref ID J:152571]

Zhou J; Tang PC; Qin L; Gayed PM; Li W; Skokos EA; Kyriakides TR; Pober JS; Tellides G. 2010. CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses. J Exp Med 207(9):1951-66. [PubMed: 20733031]  [MGI Ref ID J:165720]

Zhu B; Bando Y; Xiao S; Yang K; Anderson AC; Kuchroo VK; Khoury SJ. 2007. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 179(8):5228-37. [PubMed: 17911608]  [MGI Ref ID J:153031]

Zhu B; Kennedy JK; Wang Y; Sandoval-Garcia C; Cao L; Xiao S; Wu C; Elyaman W; Khoury SJ. 2011. Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. J Immunol 187(5):2418-32. [PubMed: 21824867]  [MGI Ref ID J:179261]

Zhu DY; Liu SH; Sun HS; Lu YM. 2003. Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. J Neurosci 23(1):223-9. [PubMed: 12514219]  [MGI Ref ID J:124823]

Zhu X; Zhao H; Graveline AR; Buys ES; Schmidt U; Bloch KD; Rosenzweig A; Chao W. 2006. MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes. Am J Physiol Heart Circ Physiol 291(4):H1900-9. [PubMed: 16648192]  [MGI Ref ID J:116319]

Zingarelli B; Szabo C; Salzman AL. 1999. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45(2):199-209. [PubMed: 10403731]  [MGI Ref ID J:56980]

Zoller EE; Lykens JE; Terrell CE; Aliberti J; Filipovich AH; Henson PM; Jordan MB. 2011. Hemophagocytosis causes a consumptive anemia of inflammation. J Exp Med 208(6):1203-14. [PubMed: 21624938]  [MGI Ref ID J:176823]

de Jonge WJ; Hallemeesch MM; Kwikkers KL; Ruijter JM; de Gier-de Vries C; van Roon MA; Meijer AJ; Marescau B; de Deyn PP; Deutz NE; Lamers WH. 2002. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development. Am J Clin Nutr 76(1):128-40. [PubMed: 12081826]  [MGI Ref ID J:80556]

de Jonge WJ; Kwikkers KL; te Velde AA; van Deventer SJ; Nolte MA; Mebius RE; Ruijter JM; Lamers MC; Lamers WH. 2002. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. J Clin Invest 110(10):1539-48. [PubMed: 12438451]  [MGI Ref ID J:80204]

van Der Heyde HC; Gu Y; Zhang Q; Sun G; Grisham MB. 2000. Nitric oxide is neither necessary nor sufficient for resolution of plasmodium chabaudi malaria in mice J Immunol 165(6):3317-23. [PubMed: 10975849]  [MGI Ref ID J:64564]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

Tg(Thy1-APPSwDutIowa)BWevn related

Burgess BL; McIsaac SA; Naus KE; Chan JY; Tansley GH; Yang J; Miao F; Ross CJ; van Eck M; Hayden MR; van Nostrand W; St George-Hyslop P; Westaway D; Wellington CL. 2006. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 24(1):114-27. [PubMed: 16899370]  [MGI Ref ID J:113199]

Carrasco J; Adlard P; Cotman C; Quintana A; Penkowa M; Xu F; Van Nostrand WE; Hidalgo J. 2006. Metallothionein-I and -III expression in animal models of Alzheimer disease. Neuroscience 143(4):911-22. [PubMed: 17027170]  [MGI Ref ID J:117948]

Chow N; Bell RD; Deane R; Streb JW; Chen J; Brooks A; Van Nostrand W; Miano JM; Zlokovic BV. 2007. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A 104(3):823-8. [PubMed: 17215356]  [MGI Ref ID J:119251]

Davis J; Xu F; Deane R; Romanov G; Previti ML; Zeigler K; Zlokovic BV; Van Nostrand WE. 2004. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 279(19):20296-306. [PubMed: 14985348]  [MGI Ref ID J:89848]

Davis J; Xu F; Miao J; Previti ML; Romanov G; Ziegler K; Van Nostrand WE. 2006. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double Ass in human AssPP transgenic mice. Neurobiol Aging 27(7):946-54. [PubMed: 16105708]  [MGI Ref ID J:108851]

Dhurandhar EJ; Allison DB; van Groen T; Kadish I. 2013. Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model. PLoS One 8(4):e60437. [PubMed: 23565247]  [MGI Ref ID J:200150]

Fan R; Defilippis K; Van Nostrand WE. 2007. Induction of complement proteins in a mouse model of cerebral microvascular Abeta deposition. J Neuroinflammation 4(1):22. [PubMed: 17877807]  [MGI Ref ID J:124911]

Frake RA; Ricketts T; Menzies FM; Rubinsztein DC. 2015. Autophagy and neurodegeneration. J Clin Invest 125(1):65-74. [PubMed: 25654552]  [MGI Ref ID J:219892]

Frost JL; Le KX; Cynis H; Ekpo E; Kleinschmidt M; Palmour RM; Ervin FR; Snigdha S; Cotman CW; Saido TC; Vassar RJ; George-Hyslop PS; Ikezu T; Schilling S; Demuth HU; Lemere CA. 2013. Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models. Am J Pathol 183(2):369-81. [PubMed: 23747948]  [MGI Ref ID J:199082]

Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. [PubMed: 16207707]  [MGI Ref ID J:105900]

Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. [PubMed: 17764851]  [MGI Ref ID J:128390]

Kan MJ; Lee JE; Wilson JG; Everhart AL; Brown CM; Hoofnagle AN; Jansen M; Vitek MP; Gunn MD; Colton CA. 2015. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci 35(15):5969-82. [PubMed: 25878270]  [MGI Ref ID J:221677]

Liao MC; Van Nostrand WE. 2010. Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. Biochemistry 49(6):1127-36. [PubMed: 20050683]  [MGI Ref ID J:159886]

Lonskaya I; Hebron ML; Desforges NM; Schachter JB; Moussa CE. 2014. Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. J Mol Med (Berl) 92(4):373-86. [PubMed: 24337465]  [MGI Ref ID J:221697]

Medeiros R; Kitazawa M; Caccamo A; Baglietto-Vargas D; Estrada-Hernandez T; Cribbs DH; Fisher A; Laferla FM. 2011. Loss of muscarinic m(1) receptor exacerbates Alzheimer's disease-like pathology and cognitive decline. Am J Pathol 179(2):980-91. [PubMed: 21704011]  [MGI Ref ID J:174403]

Miao J; Vitek MP; Xu F; Previti ML; Davis J; Van Nostrand WE. 2005. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-7. [PubMed: 16000616]  [MGI Ref ID J:99430]

Miao J; Xu F; Davis J; Otte-Holler I; Verbeek MM; Van Nostrand WE. 2005. Cerebral Microvascular Amyloid {beta} Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid {beta} Precursor Protein. Am J Pathol 167(2):505-15. [PubMed: 16049335]  [MGI Ref ID J:99946]

Passos GF; Medeiros R; Cheng D; Vasilevko V; Laferla FM; Cribbs DH. 2013. The Bradykinin B1 Receptor Regulates Abeta Deposition and Neuroinflammation in Tg-SwDI Mice. Am J Pathol 182(5):1740-9. [PubMed: 23470163]  [MGI Ref ID J:195541]

Ridnour LA; Dhanapal S; Hoos M; Wilson J; Lee J; Cheng RY; Brueggemann EE; Hines HB; Wilcock DM; Vitek MP; Wink DA; Colton CA. 2012. Nitric oxide-mediated regulation of beta-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem 123(5):736-49. [PubMed: 23016931]  [MGI Ref ID J:190735]

Sagare AP; Bell RD; Zhao Z; Ma Q; Winkler EA; Ramanathan A; Zlokovic BV. 2013. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun 4:2932. [PubMed: 24336108]  [MGI Ref ID J:221300]

Searcy JL; Le Bihan T; Salvadores N; McCulloch J; Horsburgh K. 2014. Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice. PLoS One 9(2):e89970. [PubMed: 24587158]  [MGI Ref ID J:214476]

Van Vickle GD; Esh CL; Daugs ID; Kokjohn TA; Kalback WM; Patton RL; Luehrs DC; Walker DG; Lue LF; Beach TG; Davis J; Van Nostrand WE; Castano EM; Roher AE. 2008. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol 173(2):483-93. [PubMed: 18599612]  [MGI Ref ID J:137886]

Wilcock DM; Gharkholonarehe N; Van Nostrand WE; Davis J; Vitek MP; Colton CA. 2009. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci 29(25):7957-65. [PubMed: 19553436]  [MGI Ref ID J:150418]

Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. [PubMed: 18272675]  [MGI Ref ID J:132221]

Wilcock DM; Vitek MP; Colton CA. 2009. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience 159(3):1055-69. [PubMed: 19356689]  [MGI Ref ID J:148938]

Xu F; Grande AM; Robinson JK; Previti ML; Vasek M; Davis J; Van Nostrand WE. 2007. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. Neuroscience 146(1):98-107. [PubMed: 17331655]  [MGI Ref ID J:122063]

Xu F; Vitek MP; Colton CA; Previti ML; Gharkholonarehe N; Davis J; Van Nostrand WE. 2008. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J Neurosci 28(20):5312-20. [PubMed: 18480287]  [MGI Ref ID J:136318]

Zeng Y; Callaghan D; Xiong H; Yang Z; Huang P; Zhang W. 2012. Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice. J Neurochem :. [PubMed: 22578166]  [MGI Ref ID J:186567]

Zhang L; Dasuri K; Fernandez-Kim SO; Bruce-Keller AJ; Freeman LR; Pepping JK; Beckett TL; Murphy MP; Keller JN. 2013. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochim Biophys Acta 1832(9):1456-62. [PubMed: 23313575]  [MGI Ref ID J:202444]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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