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| The ILSXISS#/Tej recombinant inbred (RI) strains originate from crosses between ILS/IbgTejJ (009324) and ISS/IbgTejJ (009325) They may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits and complex or potentially complex physiologic phenotypes (including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight). | ||||||||||||||||||||||
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Description
Strain Information
Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 14-MAY-09 Species laboratory mouse RI progenitor ILS/IbgTejJ ISS/IbgTejJ Generation F31+F4 (02-JAN-11)
Generation DefinitionsDonating Investigator Thomas Johnson, University of Colorado at Boulder Description
The ILSXISS recombinant inbred (RI) strains are used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits including ethanol-induced loss of righting, psychomotor activation, hypothermia, blood ethanol concentration at wakening and numerous morphometric CNS traits as well as complex or potentially complex physiologic phenotypes including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight.Development
The ILSXISS#/Tej (formerly LXS) recombinant inbred lines were generated from crosses between ILS/Ibg (Inbred Long Sleep)(009324) and ISS/Ibg(Inbred Short Sleep) (009325). These two progenitor strains were developed from the LS and SS selected lines derived from a heterogenous stock derived from an 8 way cross (A, AKR, BALB/c, C3H/2, C57BL, DBA/2, IS/Bi and RIII) created at the Cancer Research Genetics Laboratory at the University of California, Berkley. ILS and ISS are the product of inbreeding LS and SS, lines selected for long or short duration of loss-of-righting response following high dose intraperitoneal administration of ethanol.The ILSXISS set was initiated in the laboratory of John DeFries and colleagues at the Institute of Behavioral Genetics, Boulder CO in 1996. Crosses at the F2 generation ensured that the Y chromosome and mitochondrial genes were randomly segregating. Three hundred-thirty MIT markers were used for screening. Seventy-seven RI strains reached the 22nd generation of inbreeding, however, since that time, a number have become extinct. Approximately 65 lines and the progenitors were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
Related Strains
ILSXISS Strains
View ILSXISS Strains (61 strains)
Phenotype
Phenotype Information
Mouse Phenome Database
This mouse can be used to support research in many areas including:
Research Tools
Genetics Research
Gene Mapping
Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Genes & Alleles
Gene & Allele Information provided by MGI
Currently there are no related genes or alleles for this strain.References
References provided by MGI
Selected Reference(s)
Williams RW; Bennett B; Lu L; Gu J; DeFries JC; Carosone-Link PJ; Rikke BA; Belknap JK; Johnson TE. 2004. Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome 15(8):637-47. [PubMed: 15457343] [MGI Ref ID J:93073]
Additional References
Bennett B; Carosone-Link P. 2006. Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts. Genes Brain Behav 5(5):404-12. [PubMed: 16879634] [MGI Ref ID J:114153]
Bennett B; Carosone-Link P; Zahniser NR; Johnson TE. 2006. Confirmation and fine mapping of ethanol sensitivity quantitative trait loci, and candidate gene testing in the LXS recombinant inbred mice. J Pharmacol Exp Ther 319(1):299-307. [PubMed: 16803863] [MGI Ref ID J:114558]
Bennett B; Carosone-Link PJ; Lu L; Chesler EJ; Johnson TE. 2005. Genetics of body weight in the LXS recombinant inbred mouse strains. Mamm Genome 16(10):764-74. [PubMed: 16261418] [MGI Ref ID J:102637]
Downing C; Carosone-Link P; Bennett B; Johnson T. 2006. QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. Alcohol Clin Exp Res 30(7):1111-20. [PubMed: 16792557] [MGI Ref ID J:114560]
Haughey HM; Kaiser AL; Johnson TE; Bennett B; Sikela JM; Zahniser NR. 2005. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 29(10):1759-68. [PubMed: 16269905] [MGI Ref ID J:145526]
Rikke BA; Battaglia ME; Allison DB; Johnson TE. 2006. Murine weight loss exhibits significant genetic variation during dietary restriction. Physiol Genomics 27(2):122-30. [PubMed: 16849633] [MGI Ref ID J:113658]
Rikke BA; Johnson TE. 2007. Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses. Am J Physiol Regul Integr Comp Physiol 293(4):R1522-7. [PubMed: 17686887] [MGI Ref ID J:145527]
Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2004. Quantitative trait Loci specifying the response of body temperature to dietary restriction. J Gerontol A Biol Sci Med Sci 59(2):118-25. [PubMed: 14999024] [MGI Ref ID J:88523]
Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2003. Strain variation in the response of body temperature to dietary restriction. Mech Ageing Dev 124(5):663-78. [PubMed: 12735906] [MGI Ref ID J:145528]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number MGL377
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 14-MAY-09 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $125.00 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
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Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $162.50 Female or Male Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
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Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- This strain is included in the Special Mutant Stock Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
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