|The ILSXISS#/Tej recombinant inbred (RI) strains originate from crosses between ILS/IbgTejJ (009324) and ISS/IbgTejJ (009325) They may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits and complex or potentially complex physiologic phenotypes (including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight).|
Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 06-APR-09 Species laboratory mouse RI progenitor ILS/IbgTejJ ISS/IbgTejJ Generation F35+F15 (17-NOV-14)
Donating Investigator Thomas Johnson, University of Colorado at Boulder
The ILSXISS recombinant inbred (RI) strains are used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits including ethanol-induced loss of righting, psychomotor activation, hypothermia, blood ethanol concentration at wakening and numerous morphometric CNS traits as well as complex or potentially complex physiologic phenotypes including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight.
The strain distribution pattern (SDP) for the ILSXISS RI strains is available through Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.
The ILSXISS#/Tej (formerly LXS) recombinant inbred lines were generated from crosses between ILS/Ibg (Inbred Long Sleep)(009324) and ISS/Ibg(Inbred Short Sleep) (009325). These two progenitor strains were developed from the LS and SS selected lines derived from a heterogenous stock derived from an 8 way cross (A, AKR, BALB/c, C3H/2, C57BL, DBA/2, IS/Bi and RIII) created at the Cancer Research Genetics Laboratory at the University of California, Berkley. ILS and ISS are the product of inbreeding LS and SS, lines selected for long or short duration of loss-of-righting response following high dose intraperitoneal administration of ethanol.
The ILSXISS set was initiated in the laboratory of John DeFries and colleagues at the Institute of Behavioral Genetics, Boulder CO in 1996. Crosses at the F2 generation ensured that the Y chromosome and mitochondrial genes were randomly segregating. Three hundred-thirty MIT markers were used for screening. Seventy-seven RI strains reached the 22nd generation of inbreeding, however, since that time, a number have become extinct. Approximately 65 lines and the progenitors were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
|Considerations for Choosing Controls|
009324 ILS/IbgTejJ 009287 ILSXISS100/TejJ 009322 ILSXISS101/TejJ 009288 ILSXISS102/TejJ 009289 ILSXISS103/TejJ 009290 ILSXISS107/TejJ 009291 ILSXISS110/TejJ 009323 ILSXISS112/TejJ 009292 ILSXISS114/TejJ 009293 ILSXISS115/TejJ 009294 ILSXISS122/TejJ 009295 ILSXISS123/TejJ 009260 ILSXISS13/TejJ 009261 ILSXISS14/TejJ 009262 ILSXISS16/TejJ 009263 ILSXISS19/TejJ 009264 ILSXISS22/TejJ 009265 ILSXISS23/TejJ 009300 ILSXISS24/TejJ 009301 ILSXISS25/TejJ 009302 ILSXISS26/TejJ 009266 ILSXISS28/TejJ 009257 ILSXISS3/TejJ 009303 ILSXISS32/TejJ 009304 ILSXISS34/TejJ 009267 ILSXISS36/TejJ 009268 ILSXISS41/TejJ 009307 ILSXISS42/TejJ 009308 ILSXISS43/TejJ 009269 ILSXISS46/TejJ 009270 ILSXISS48/TejJ 009271 ILSXISS49/TejJ 009258 ILSXISS5/TejJ 009309 ILSXISS50/TejJ 009272 ILSXISS51/TejJ 009273 ILSXISS52/TejJ 009311 ILSXISS60/TejJ 009312 ILSXISS64/TejJ 009275 ILSXISS66/TejJ 009259 ILSXISS7/TejJ 009276 ILSXISS70/TejJ 009277 ILSXISS73/TejJ 009278 ILSXISS75/TejJ 009279 ILSXISS76/TejJ 009315 ILSXISS78/TejJ 009297 ILSXISS8/TejJ 009316 ILSXISS80/TejJ 009317 ILSXISS84/TejJ 009280 ILSXISS86/TejJ 009318 ILSXISS87/TejJ 009281 ILSXISS89/TejJ 009298 ILSXISS9/TejJ 009282 ILSXISS90/TejJ 009283 ILSXISS92/TejJ 009319 ILSXISS93/TejJ 009284 ILSXISS94/TejJ 009320 ILSXISS96/TejJ 009285 ILSXISS97/TejJ 009321 ILSXISS98/TejJ 009286 ILSXISS99/TejJ 009325 ISS/IbgTejJView ILSXISS Strains (61 strains)
View Phenotypic DataPhenotypic DataView Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Williams RW; Bennett B; Lu L; Gu J; DeFries JC; Carosone-Link PJ; Rikke BA; Belknap JK; Johnson TE. 2004. Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome 15(8):637-47. [PubMed: 15457343] [MGI Ref ID J:93073]
Bennett B; Carosone-Link P. 2006. Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts. Genes Brain Behav 5(5):404-12. [PubMed: 16879634] [MGI Ref ID J:114153]
Bennett B; Carosone-Link P; Zahniser NR; Johnson TE. 2006. Confirmation and fine mapping of ethanol sensitivity quantitative trait loci, and candidate gene testing in the LXS recombinant inbred mice. J Pharmacol Exp Ther 319(1):299-307. [PubMed: 16803863] [MGI Ref ID J:114558]
Bennett B; Carosone-Link PJ; Lu L; Chesler EJ; Johnson TE. 2005. Genetics of body weight in the LXS recombinant inbred mouse strains. Mamm Genome 16(10):764-74. [PubMed: 16261418] [MGI Ref ID J:102637]
Downing C; Carosone-Link P; Bennett B; Johnson T. 2006. QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. Alcohol Clin Exp Res 30(7):1111-20. [PubMed: 16792557] [MGI Ref ID J:114560]
Haughey HM; Kaiser AL; Johnson TE; Bennett B; Sikela JM; Zahniser NR. 2005. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 29(10):1759-68. [PubMed: 16269905] [MGI Ref ID J:145526]
McClearn GE; Wilson JR; Meredith W. 1970. The use of isogenic and heterogenic mouse stocks in behavioral research. In: Contribution to Behavior-Genetic Analysis. The Mouse as a Prototype. Appleton-Century-Crofts, New York. [MGI Ref ID J:23468]
Rikke BA; Battaglia ME; Allison DB; Johnson TE. 2006. Murine weight loss exhibits significant genetic variation during dietary restriction. Physiol Genomics 27(2):122-30. [PubMed: 16849633] [MGI Ref ID J:113658]
Rikke BA; Johnson TE. 2007. Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses. Am J Physiol Regul Integr Comp Physiol 293(4):R1522-7. [PubMed: 17686887] [MGI Ref ID J:145527]
Rikke BA; Liao CY; McQueen MB; Nelson JF; Johnson TE. 2010. Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension. Exp Gerontol 45(9):691-701. [PubMed: 20452416] [MGI Ref ID J:164267]
Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2004. Quantitative trait Loci specifying the response of body temperature to dietary restriction. J Gerontol A Biol Sci Med Sci 59(2):118-25. [PubMed: 14999024] [MGI Ref ID J:88523]
Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2003. Strain variation in the response of body temperature to dietary restriction. Mech Ageing Dev 124(5):663-78. [PubMed: 12735906] [MGI Ref ID J:145528]
Swindell WR. 2012. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev 11(2):254-70. [PubMed: 22210149] [MGI Ref ID J:204726]
Animal Health ReportsRoom Number FGB27
Mating System Sibling x Sibling (Female x Male) 06-APR-09 Diet Information LabDiet® 5K52/5K67
This strain is currently Under Development for Cryo.
|Considerations for Choosing Controls|
|Control Pricing Information for Genetically Engineered Mutant Strains.|
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