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Under Development for Cryo

Use Restrictions Apply, see Terms of Use
Register Interest
Common Names: LXS39;    
The ILSXISS#/Tej recombinant inbred (RI) strains originate from crosses between ILS/IbgTejJ (009324) and ISS/IbgTejJ (009325) They may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits and complex or potentially complex physiologic phenotypes (including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight).


The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Recombinant Inbred (RI);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   06-APR-09
Specieslaboratory mouse
RI progenitor ILS/IbgTejJ ISS/IbgTejJ
GenerationF35+F16 (04-MAY-15)
Generation Definitions
Donating Investigator Thomas Johnson,   University of Colorado at Boulder

The ILSXISS recombinant inbred (RI) strains are used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits including ethanol-induced loss of righting, psychomotor activation, hypothermia, blood ethanol concentration at wakening and numerous morphometric CNS traits as well as complex or potentially complex physiologic phenotypes including differences in longevity under ad libitum and dietary restriction conditions, aging, body temperature and body weight.

The strain distribution pattern (SDP) for the ILSXISS RI strains is available through Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network.

The ILSXISS#/Tej (formerly LXS) recombinant inbred lines were generated from crosses between ILS/Ibg (Inbred Long Sleep)(009324) and ISS/Ibg(Inbred Short Sleep) (009325). These two progenitor strains were developed from the LS and SS selected lines derived from a heterogenous stock derived from an 8 way cross (A, AKR, BALB/c, C3H/2, C57BL, DBA/2, IS/Bi and RIII) created at the Cancer Research Genetics Laboratory at the University of California, Berkley. ILS and ISS are the product of inbreeding LS and SS, lines selected for long or short duration of loss-of-righting response following high dose intraperitoneal administration of ethanol.

The ILSXISS set was initiated in the laboratory of John DeFries and colleagues at the Institute of Behavioral Genetics, Boulder CO in 1996. Crosses at the F2 generation ensured that the Y chromosome and mitochondrial genes were randomly segregating. Three hundred-thirty MIT markers were used for screening. Seventy-seven RI strains reached the 22nd generation of inbreeding, however, since that time, a number have become extinct. Approximately 65 lines and the progenitors were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.

Control Information

   None Available
  Considerations for Choosing Controls

Related Strains

009324   ILS/IbgTejJ
009287   ILSXISS100/TejJ
009322   ILSXISS101/TejJ
009288   ILSXISS102/TejJ
009289   ILSXISS103/TejJ
009290   ILSXISS107/TejJ
009291   ILSXISS110/TejJ
009323   ILSXISS112/TejJ
009292   ILSXISS114/TejJ
009293   ILSXISS115/TejJ
009294   ILSXISS122/TejJ
009295   ILSXISS123/TejJ
009260   ILSXISS13/TejJ
009261   ILSXISS14/TejJ
009262   ILSXISS16/TejJ
009263   ILSXISS19/TejJ
009264   ILSXISS22/TejJ
009265   ILSXISS23/TejJ
009300   ILSXISS24/TejJ
009301   ILSXISS25/TejJ
009302   ILSXISS26/TejJ
009266   ILSXISS28/TejJ
009257   ILSXISS3/TejJ
009303   ILSXISS32/TejJ
009304   ILSXISS34/TejJ
009267   ILSXISS36/TejJ
009268   ILSXISS41/TejJ
009307   ILSXISS42/TejJ
009308   ILSXISS43/TejJ
009269   ILSXISS46/TejJ
009270   ILSXISS48/TejJ
009271   ILSXISS49/TejJ
009258   ILSXISS5/TejJ
009309   ILSXISS50/TejJ
009272   ILSXISS51/TejJ
009273   ILSXISS52/TejJ
009311   ILSXISS60/TejJ
009312   ILSXISS64/TejJ
009275   ILSXISS66/TejJ
009259   ILSXISS7/TejJ
009276   ILSXISS70/TejJ
009277   ILSXISS73/TejJ
009278   ILSXISS75/TejJ
009279   ILSXISS76/TejJ
009315   ILSXISS78/TejJ
009297   ILSXISS8/TejJ
009316   ILSXISS80/TejJ
009317   ILSXISS84/TejJ
009280   ILSXISS86/TejJ
009318   ILSXISS87/TejJ
009281   ILSXISS89/TejJ
009298   ILSXISS9/TejJ
009282   ILSXISS90/TejJ
009283   ILSXISS92/TejJ
009319   ILSXISS93/TejJ
009284   ILSXISS94/TejJ
009320   ILSXISS96/TejJ
009285   ILSXISS97/TejJ
009321   ILSXISS98/TejJ
009286   ILSXISS99/TejJ
009325   ISS/IbgTejJ
View ILSXISS Strains     (61 strains)


Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Williams RW; Bennett B; Lu L; Gu J; DeFries JC; Carosone-Link PJ; Rikke BA; Belknap JK; Johnson TE. 2004. Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis. Mamm Genome 15(8):637-47. [PubMed: 15457343]  [MGI Ref ID J:93073]

Additional References

Bennett B; Carosone-Link P. 2006. Replication of small effect quantitative trait loci for behavioral traits facilitated by estimation of effect size from independent cohorts. Genes Brain Behav 5(5):404-12. [PubMed: 16879634]  [MGI Ref ID J:114153]

Bennett B; Carosone-Link P; Zahniser NR; Johnson TE. 2006. Confirmation and fine mapping of ethanol sensitivity quantitative trait loci, and candidate gene testing in the LXS recombinant inbred mice. J Pharmacol Exp Ther 319(1):299-307. [PubMed: 16803863]  [MGI Ref ID J:114558]

Bennett B; Carosone-Link PJ; Lu L; Chesler EJ; Johnson TE. 2005. Genetics of body weight in the LXS recombinant inbred mouse strains. Mamm Genome 16(10):764-74. [PubMed: 16261418]  [MGI Ref ID J:102637]

Downing C; Carosone-Link P; Bennett B; Johnson T. 2006. QTL mapping for low-dose ethanol activation in the LXS recombinant inbred strains. Alcohol Clin Exp Res 30(7):1111-20. [PubMed: 16792557]  [MGI Ref ID J:114560]

Haughey HM; Kaiser AL; Johnson TE; Bennett B; Sikela JM; Zahniser NR. 2005. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res 29(10):1759-68. [PubMed: 16269905]  [MGI Ref ID J:145526]

McClearn GE; Wilson JR; Meredith W. 1970. The use of isogenic and heterogenic mouse stocks in behavioral research. In: Contribution to Behavior-Genetic Analysis. The Mouse as a Prototype. Appleton-Century-Crofts, New York.  [MGI Ref ID J:23468]

Rikke BA; Battaglia ME; Allison DB; Johnson TE. 2006. Murine weight loss exhibits significant genetic variation during dietary restriction. Physiol Genomics 27(2):122-30. [PubMed: 16849633]  [MGI Ref ID J:113658]

Rikke BA; Johnson TE. 2007. Physiological genetics of dietary restriction: uncoupling the body temperature and body weight responses. Am J Physiol Regul Integr Comp Physiol 293(4):R1522-7. [PubMed: 17686887]  [MGI Ref ID J:145527]

Rikke BA; Liao CY; McQueen MB; Nelson JF; Johnson TE. 2010. Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension. Exp Gerontol 45(9):691-701. [PubMed: 20452416]  [MGI Ref ID J:164267]

Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2004. Quantitative trait Loci specifying the response of body temperature to dietary restriction. J Gerontol A Biol Sci Med Sci 59(2):118-25. [PubMed: 14999024]  [MGI Ref ID J:88523]

Rikke BA; Yerg JE 3rd; Battaglia ME; Nagy TR; Allison DB; Johnson TE. 2003. Strain variation in the response of body temperature to dietary restriction. Mech Ageing Dev 124(5):663-78. [PubMed: 12735906]  [MGI Ref ID J:145528]

Swindell WR. 2012. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev 11(2):254-70. [PubMed: 22210149]  [MGI Ref ID J:204726]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   06-APR-09
Diet Information New Diet as of March 2015: Lab Diet® 5K0Q (6% fat)

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


This strain is currently Under Development for Cryo.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

Control Information

   None Available
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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