Strain Name:

SAMP1/YitFcsJ

Stock Number:

009355

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: SAMP1/Fc;     SAMP1/YitFc;    
SAMP1/YitFcs mice develop a spontaneous ileitis that is similar in many features to the human inflammatory bowel Crohn's disease.

Description

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   24-NOV-09
Specieslaboratory mouse
H2 HaplotypeH2k (also called H-2k or H2k)
GenerationF?+F11 (10-DEC-13)
Generation Definitions
 
Donating Investigator Marcia J McDuffie,   University of Virginia Dept of Medicine

Important Note
These SAMP1 mice have significant breeding difficulties. Please see the JAXMice Health & Husbandry section for the SAMP1 mice Colony Maintenance / Breeding & Husbandry description.

Description
SAMP1/YitFcs (also called SAMP1/YitFc or SAMP1/Fc) mice develop a spontaneous ileitis that is similar in many features to human Crohn's disease. Development of ileitis is accelerated by the presence of luminal bacteria and is characterized by discontinuous segmental inflammation involving the ileum while sparing the proximal small intestine and colon. The histopathologic features of SAMP1/Fc ileitis include transmural inflammation, crypt abscesses, and epithelial changes including loss of villi, crypt elongation, and crypt branching. SAMP1/Fc mice were originally distinguished from the strain from which they were derived (SAMP1/Yit) by spontaneous onset of ileum inflammation by 10 weeks of age at nearly 100% penetrance and the emergence of a perianal fistulizing disease not reported in the parental strain. Other distinguishing characteristics of the SAMP1/Fc substrain include incidence of skin lesions inversely correlated with the occurrence of intestinal inflammation, chronic ileitis with prominent muscular hypertrophy and focal collagen deposition in inflamed segments, activation of mesenteric lymph node lymphocytes coincident with ileitis progression, and high interferon-γ production preceding ileitis onset. Like other spontaneous models of inflammatory bowel disease, SAMP1/Fc mice maintained at higher health status/germ-free conditions may exhibit attenuated ileitis onset and severity compared to SAMP1/Fc mice maintained in lower health status/specific pathogen-free vivaria.

Development
Siblings from a litter of AKR/J inbred mice (from The Jackson Laboratory; Stock No. 000648) were inadvertently outcrossed to an unknown mouse, and then bred together for more than 20 generations to generate a series of senescence prone strains. One of these senescence accelerated mice (SAM) strains, SAMP1, was identified with shortened life span and early signs of senescence (spontaneous amyloidosis, alopecia, and osteoporosis) by Dr. T Takeda (Kyoto University, Kyoto, Japan). SAMP1 mice were then sent to Dr. S Matsumoto (Yakult Central Institute for Microbiological Research, Tokyo, Japan), where mice showing spontaneous skin ulceration were selectively mated together. During a transfer from a conventional to specific pathogen free vivaria, mice lost the early senescence (amyloidosis) and developed a transmural, discontinuous ileitis and mild hepatic inflammation without necrosis. After more than 20 generations of inbreeding, the resulting SAMP1/Yit mice were established. In 1996, SAMP1/Yit mice were then sent to Dr. Fabio Cominelli (University of Virginia School of Medicine, Charlottesville Virginia, USA) where they were bred together for more than 20 generations. The resulting SAMP1/YitFcs mice (originally called SAMP1/YitFc or SAMP1/Fc) retained the high prevalence of spontaneous ileitis but also show unique characteristics compared with the original Japanese strain; incidence of skin lesions inversely correlated with the occurrence of intestinal inflammation, established ileitis as early as 10 weeks of age, chronic ileitis with prominent muscular hypertrophy and focal collagen deposition in inflamed segments, activation of mesenteric lymph node lymphocytes coincident with ileitis progression, high interferon-γ production preceding ileitis onset, and emergence of perianal disease with ulceration and fistulae. SAMP1/YitFcs mice are H-2k; reported to have the entire MHC region on chromosome 17 identical to that of AKR/J mice. In 2009, SAMP1/YitFcs mice were sent from the University of Virginia School of Medicine to The Jackson Laboratory and assigned the strain name SAMP1/YitFcsJ.

Control Information

  Control
   000648 AKR/J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Dermatology Research
Skin and Hair Texture Defects

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines
Immunodeficiency
      Inflammatory bowel disease
Inflammation
      Inflammatory bowel disease

Internal/Organ Research
Gastrointestinal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Barnes SL; Vidrich A; Wang ML; Wu GD; Cominelli F; Rivera-Nieves J; Bamias G; Cohn SM. 2007. Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. J Immunol 179(10):7012-20. [PubMed: 17982092]  [MGI Ref ID J:149582]

Kosiewicz MM; Nast CC; Krishnan A; Rivera-Nieves J; Moskaluk CA; Matsumoto S; Kozaiwa K; Cominelli F. 2001. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 107(6):695-702. [PubMed: 11254669]  [MGI Ref ID J:71168]

Kozaiwa K; Sugawara K; Smith MF Jr; Carl V; Yamschikov V; Belyea B; McEwen SB; Moskaluk CA; Pizarro TT; Cominelli F; McDuffie M. 2003. Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc. Gastroenterology 125(2):477-90. [PubMed: 12891551]  [MGI Ref ID J:84661]

Matsumoto S; Okabe Y; Setoyama H; Takayama K; Ohtsuka J; Funahashi H; Imaoka A; Okada Y; Umesaki Y. 1998. Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain. Gut 43(1):71-8. [PubMed: 9771408]  [MGI Ref ID J:49022]

Rivera-Nieves J; Bamias G; Vidrich A; Marini M; Pizarro TT; McDuffie MJ; Moskaluk CA; Cohn SM; Cominelli F. 2003. Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology 124(4):972-82. [PubMed: 12671894]  [MGI Ref ID J:83399]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, SAMP1/YitFcJ inbred mice are bred together. These inbred mice have significant breeding difficulties. The donating investigator reports:
--it is best to maintain the colony in trio-matings
--approximately 33% of trio-matings are nonproductive
--approximately 33% of trio-matings will only produce one litter
--productive matings produce approximately 2 litters total with an average of 4.8 mice per wean
--if females are not pregnant by 6 weeks of breeding, that female is unlikely to produce any litters
--the donating investigator does not set up mating pens until the mice are at least eight weeks old: even with this delayed mating, litters may not be observed for a few months
--seasonal breeding slumps starting in January may further diminish colony breeding success.
Mating SystemSibling x Sibling         (Female x Male)   24-NOV-09
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $239.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $310.70Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000648 AKR/J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

These SAMP1 mice have significant breeding difficulties. Please see the JAXMice Health & Husbandry section for the SAMP1 mice Colony Maintenance / Breeding & Husbandry description.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)