Strain Name:

B6.129X1-Mark2tm1Hpw/J

Stock Number:

009365

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
Homozygous Mark2 (MAP/microtubule affinity-regulating kinase 2) targeted mice show and increased metabolic rate, decreased adiposity, resistance to high fat diet-induced weight gain, and insulin hypersensitivity. Approximately 85% of homozygotes exhibit some combination of immunological disorders between the ages of 5 and 12 months. Aging animals (~6-7 months) develop splenomegaly, lymphadenopathy, membranoproliferative glomerulonephritis, and lymphocytic infiltrates in the lungs, parotid glands and kidneys. Roughly 30% of homozygotes present colorectal prolapse that is more severe in females than males after the age of 5 months. This strain may be useful in studies of immune system homeostasis, autoimmune disease, obesity, and diabetes.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN18pN1
Generation Definitions
 
Donating InvestigatorDr. Helen Piwnica-Worms,   MD Anderson Cancer Center

Description
Homozygous targeted mice show and increased metabolic rate, decreased adiposity, resistance to high fat diet-induced weight gain, and insulin hypersensitivity. Western blot analysis demonstrates that expression is eliminated in brain, spleen, kidney and liver, lymph nodes, thymus, white and brown adipose tissues, large and small intestines, stomach. Homozygous pups are born slightly below predicted Mendelian ratios and show both embryonic and postnatal growth retardation as well as increased mortality as compared to wildtype animals. The age of death can range from 3 weeks to several months. Approximately 85% of homozygotes exhibit some combination of immunological disorders between the ages of 5 and 12 months. B and T cell development is normal, but CD4+ T cells lacking this protein exhibit a marked upregulation of the memory marker CD44 and produce more gamma interferon and interleukin 4 on stimulation through the T cell receptor in vitro. B cell responses to T cell-dependent and -independent antigen challenge are altered in vivo. Aging animals (~6-7 months) develop splenomegaly, lymphadenopathy, membranoproliferative glomerulonephritis, and lymphocytic infiltrates in the lungs, parotid glands and kidneys. Roughly 30% of homozygotes present colorectal prolapse that is more severe in females than males after the age of 5 months. This strain may be useful in studies of immune system homeostasis, autoimmune disease, obesity, and diabetes.

Development
A portion of exon 2 and all of exons 3 and 4 were replaced by a selection cassette containing the neomycin phosphotransferase cDNA flanked 5' by the thymidine kinase promoter and 3' by the thymidine kinase polyadenylation sequence. The mutation was created using 129X1/SvJ-derived RW-4 embryonic stem (ES) cells. Male chimeras were bred to C57BL/6 females. The line was backcrossed 18 times to C57BL/6 by the donating laboratory.

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Mark2tm1Hpw/Mark2+

        involves: 129X1/SvJ * C57BL/6
  • homeostasis/metabolism phenotype
  • increased urine protein level
    • in 1 of 8 males   (MGI Ref ID J:68830)
    • hemoglobinuria
      • in 2 of 11 females   (MGI Ref ID J:68830)
  • digestive/alimentary phenotype
  • rectal prolapse
    • 3 of 107 mice exhibit colorectal prolapse   (MGI Ref ID J:68830)
  • growth/size/body phenotype
  • decreased body weight
  • renal/urinary system phenotype
  • increased urine protein level
    • in 1 of 8 males   (MGI Ref ID J:68830)
    • hemoglobinuria
      • in 2 of 11 females   (MGI Ref ID J:68830)

Mark2tm1Hpw/Mark2tm1Hpw

        involves: 129X1/SvJ * C57BL/6
  • mortality/aging
  • partial postnatal lethality
    • slightly fewer than expected mice are found at 3 weeks   (MGI Ref ID J:68830)
  • reproductive system phenotype
  • decreased litter size
    • female mice bred with wild-type mice produce smaller than expected litters   (MGI Ref ID J:68830)
  • immune system phenotype
  • abnormal CD4-positive, alpha beta T cell morphology
    • CD4+ T cells exhibit increased levels of memory markers compared with wild-type cells   (MGI Ref ID J:68830)
  • abnormal immune system physiology
    • at 5 to 12 months, 85% of mice exhibit some immunological disorders unlike wild-type mice   (MGI Ref ID J:68830)
    • abnormal humoral immune response
      • T-cell-dependent IgG1 and IgG2a response to NP-KLH are 7.5-fold and 9.5-fold, respectively, compared with wild-type mice   (MGI Ref ID J:68830)
      • decreased IgG3 level
        • 17 days after treatment with NP-Ficoll, mice exhibit 3.5-fold lower serum IgG3 levels compared with similarly treated wild-type mice   (MGI Ref ID J:68830)
      • decreased IgM level
        • 17 days after treatment with NP-Ficoll, mice exhibit 4-fold lower IgM serum levels compared with similarly treated wild-type mice   (MGI Ref ID J:68830)
    • decreased B cell proliferation
      • anti-IgM stimulated B cells exhibit a 2- to 3-fold decrease in proliferation compared with wild-type cells   (MGI Ref ID J:68830)
    • increased B cell proliferation
      • anti-CD40 treated splenocytes B220+ splenocytes is slightly enhanced compared to similarly treated wild-type cells   (MGI Ref ID J:68830)
    • increased interferon-gamma secretion
      • concanavalin A or ati-CD3 antibody treated splenocytes produce 3-fold more IFN-gamma compared with similarly treated wild-type mice   (MGI Ref ID J:68830)
      • Th1 cells produce 3-fold more IFN-gamma than wild-type cells   (MGI Ref ID J:68830)
      • following TCR cross-linking, T cells produce more IFN-gamma than similarly treated wild-type cells   (MGI Ref ID J:68830)
    • increased interleukin-4 secretion
      • Th2 cells produce 3-fold more IL4 than wild-type cells   (MGI Ref ID J:68830)
      • following TCR cross-linking, T cells produce more IL4 than similarly treated wild-type cells   (MGI Ref ID J:68830)
    • kidney inflammation
      • kidneys exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
      • glomerulonephritis
        • mice exhibit membranoproliferative glomerulonephritis   (MGI Ref ID J:68830)
    • lung inflammation
      • lungs exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
    • salivary gland inflammation
      • parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
  • abnormal spleen B cell follicle morphology
    • spleens often exhibit follicular expansion due to enlarged follicular cells compared to in wild-type mice   (MGI Ref ID J:68830)
  • enlarged lymph nodes
    • in 30% of mice at 7 to 12 months   (MGI Ref ID J:68830)
    • lymph node hyperplasia
      • young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice   (MGI Ref ID J:68830)
  • enlarged spleen
    • in 30% of mice at 7 to 12 months   (MGI Ref ID J:68830)
    • increased spleen weight
      • in older mice   (MGI Ref ID J:68830)
    • spleen hyperplasia
      • spleen cellularity is increased 2-fold in older mice compared to in wild-type mice   (MGI Ref ID J:68830)
      • mice exhibit an expansion of Ter119+HSA+ lymphocytes on the spleen compared with wild-type mice   (MGI Ref ID J:68830)
  • increased B cell number
    • young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice   (MGI Ref ID J:68830)
  • homeostasis/metabolism phenotype
  • abnormal glucose homeostasis
    • insulin-stimulated glucose infusion rate and turnover are increased compared to in wild-type mice   (MGI Ref ID J:120128)
    • decreased circulating insulin level
      • 5-fold when mice are fed a high-fat diet and also decreased when mice are fed normal chow   (MGI Ref ID J:120128)
    • hypoglycemia
      • mildly under fed conditions   (MGI Ref ID J:120128)
    • improved glucose tolerance   (MGI Ref ID J:120128)
    • increased insulin sensitivity
  • decreased adiponectin level
  • decreased circulating cholesterol level
    • when mice are fed a high-fat diet   (MGI Ref ID J:120128)
  • decreased circulating insulin-like growth factor I level
    • 25% at 7 weeks   (MGI Ref ID J:120128)
  • decreased circulating leptin level
    • 5-fold when mice are fed a high-fat diet   (MGI Ref ID J:120128)
  • decreased circulating triglyceride level
    • when mice are fed a high-fat diet   (MGI Ref ID J:120128)
  • increased basal metabolism
    • 7% when fed a high fat diet   (MGI Ref ID J:120128)
  • increased energy expenditure
    • 27% when fed a high fat diet   (MGI Ref ID J:120128)
    • decreased susceptibility to diet-induced obesity
  • increased urine protein level
    • mild to severe in 29% of males and 17% of females   (MGI Ref ID J:68830)
    • hemoglobinuria
      • in 33% of males and 45% of females   (MGI Ref ID J:68830)
  • renal/urinary system phenotype
  • abnormal glomerular capillary morphology
    • thickening of the capillary walls   (MGI Ref ID J:68830)
  • increased renal glomerulus lobularity
    • glomeruli are hypercellular and lobulated unlike in wild-type mice   (MGI Ref ID J:68830)
  • increased urine protein level
    • mild to severe in 29% of males and 17% of females   (MGI Ref ID J:68830)
    • hemoglobinuria
      • in 33% of males and 45% of females   (MGI Ref ID J:68830)
  • kidney inflammation
    • kidneys exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
    • glomerulonephritis
      • mice exhibit membranoproliferative glomerulonephritis   (MGI Ref ID J:68830)
  • mesangial cell hyperplasia
    • glomeruli exhibit diffuse mesangial hypercellularity   (MGI Ref ID J:68830)
  • adipose tissue phenotype
  • abnormal adipocyte glucose uptake
    • enhanced 4-fold in white adipose tissue and increased in brown adipose tissue   (MGI Ref ID J:120128)
  • decreased brown adipose tissue amount   (MGI Ref ID J:120128)
    • BAT mass is reduced even when mice are fed a high-fat diet   (MGI Ref ID J:163905)
  • decreased percent body fat
    • 14% compared to 23% in wild-type mice   (MGI Ref ID J:120128)
  • decreased white adipose tissue amount
    • in the epididymal fat pads at 12 weeks   (MGI Ref ID J:120128)
    • WAT mass is reduced even when mice are fed a high-fat diet   (MGI Ref ID J:163905)
  • digestive/alimentary phenotype
  • rectal prolapse
    • 30% of mice exhibit colorectal prolapse   (MGI Ref ID J:68830)
    • 41% of aged females and 18% of aged males exhibit colorectal prolapse   (MGI Ref ID J:68830)
  • salivary gland inflammation
    • parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
  • growth/size/body phenotype
  • decreased body length
  • decreased body weight
  • decreased embryo weight
    • by 20% at E13.5   (MGI Ref ID J:120128)
  • decreased percent body fat
    • 14% compared to 23% in wild-type mice   (MGI Ref ID J:120128)
  • decreased susceptibility to weight gain
    • after 7 weeks on a high-fat diet, mice do not gain weight   (MGI Ref ID J:163905)
    • decreased susceptibility to diet-induced obesity
  • postnatal growth retardation   (MGI Ref ID J:68830)
  • endocrine/exocrine gland phenotype
  • salivary gland inflammation
    • parietal salivary glands exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
  • respiratory system phenotype
  • lung inflammation
    • lungs exhibit lymphocytic infiltrates unlike in wild-type mice   (MGI Ref ID J:68830)
  • hematopoietic system phenotype
  • abnormal CD4-positive, alpha beta T cell morphology
    • CD4+ T cells exhibit increased levels of memory markers compared with wild-type cells   (MGI Ref ID J:68830)
  • abnormal spleen B cell follicle morphology
    • spleens often exhibit follicular expansion due to enlarged follicular cells compared to in wild-type mice   (MGI Ref ID J:68830)
  • decreased B cell proliferation
    • anti-IgM stimulated B cells exhibit a 2- to 3-fold decrease in proliferation compared with wild-type cells   (MGI Ref ID J:68830)
  • decreased IgG3 level
    • 17 days after treatment with NP-Ficoll, mice exhibit 3.5-fold lower serum IgG3 levels compared with similarly treated wild-type mice   (MGI Ref ID J:68830)
  • decreased IgM level
    • 17 days after treatment with NP-Ficoll, mice exhibit 4-fold lower IgM serum levels compared with similarly treated wild-type mice   (MGI Ref ID J:68830)
  • enlarged spleen
    • in 30% of mice at 7 to 12 months   (MGI Ref ID J:68830)
    • increased spleen weight
      • in older mice   (MGI Ref ID J:68830)
    • spleen hyperplasia
      • spleen cellularity is increased 2-fold in older mice compared to in wild-type mice   (MGI Ref ID J:68830)
      • mice exhibit an expansion of Ter119+HSA+ lymphocytes on the spleen compared with wild-type mice   (MGI Ref ID J:68830)
  • increased B cell number
    • young and old mice exhibit lymph node hyperplasia due to an increase in B220+ cells compared to in wild-type mice   (MGI Ref ID J:68830)
  • increased B cell proliferation
    • anti-CD40 treated splenocytes B220+ splenocytes is slightly enhanced compared to similarly treated wild-type cells   (MGI Ref ID J:68830)
  • behavior/neurological phenotype
  • abnormal eating behavior
    • 2-fold when fed a high fat diet   (MGI Ref ID J:120128)
  • embryogenesis phenotype
  • decreased embryo weight
    • by 20% at E13.5   (MGI Ref ID J:120128)
  • liver/biliary system phenotype
  • decreased susceptibility to hepatic steatosis
    • in aged mice fed normal chow   (MGI Ref ID J:120128)
  • cardiovascular system phenotype
  • abnormal glomerular capillary morphology
    • thickening of the capillary walls   (MGI Ref ID J:68830)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Embryonic Lethality (Homozygous)
      incomplete
Growth Defects
      Growth Defects (homozygous)

Diabetes and Obesity Research
Obesity Without Diabetes
      diet-induced, resistant

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Immunodeficiency
      B cell defects
      T cell deficiency
Lymphoid Tissue Defects

Internal/Organ Research
Kidney Defects
Lung Defects
Lymphoid Tissue Defects

Metabolism Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mark2tm1Hpw
Allele Name targeted mutation 1, Helen Piwnica-Worms
Allele Type Targeted (Null/Knockout)
Common Name(s) Enk-; Mark2/EMK-; Par-1b-;
Mutation Made ByDr. Helen Piwnica-Worms,   MD Anderson Cancer Center
Strain of Origin129X1/SvJ
ES Cell Line NameRW-4
ES Cell Line Strain129X1/SvJ
Gene Symbol and Name Mark2, MAP/microtubule affinity-regulating kinase 2
Chromosome 19
Gene Common Name(s) AU024026; ELKL motif kinase; EMK-1; EMK1; Emk; PAR-1; Par-1b; Par1b; expressed sequence AU024026;
Molecular Note The insertion of a neomycin selection cassette deleted sequence from exons 2, 3, and 4. The replaced region encoded residues of the glycine-rich motif involved in MgATP-binding. Western blot analysis of extracts from fibroblasts showed an absence of all known isoforms produced from the targeted allele in homozygous mutant embryos. Immunoprecipitates of tissue extracts derived from homozygous mutant mice failed to phosphorylate GST-Cdc25C in vitro, incdicating ablation of kinase activity. [MGI Ref ID J:68830]

Genotyping

Genotyping Information

Genotyping Protocols

Mark2tm1Hpw, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Hurov JB; Stappenbeck TS; Zmasek CM; White LS; Ranganath SH; Russell JH; Chan AC; Murphy KM; Piwnica-Worms H. 2001. Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Mol Cell Biol 21(9):3206-19. [PubMed: 11287624]  [MGI Ref ID J:68830]

Additional References

Mark2tm1Hpw related

Fu A; Ng AC; Depatie C; Wijesekara N; He Y; Wang GS; Bardeesy N; Scott FW; Touyz RM; Wheeler MB; Screaton RA. 2009. Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab 10(4):285-95. [PubMed: 19808021]  [MGI Ref ID J:153661]

Granot Z; Swisa A; Magenheim J; Stolovich-Rain M; Fujimoto W; Manduchi E; Miki T; Lennerz JK; Stoeckert CJ Jr; Meyuhas O; Seino S; Permutt MA; Piwnica-Worms H; Bardeesy N; Dor Y. 2009. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab 10(4):296-308. [PubMed: 19808022]  [MGI Ref ID J:153660]

Hurov JB; Huang M; White LS; Lennerz J; Choi CS; Cho YR; Kim HJ; Prior JL; Piwnica-Worms D; Cantley LC; Kim JK; Shulman GI; Piwnica-Worms H. 2007. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A 104(13):5680-5. [PubMed: 17372192]  [MGI Ref ID J:120128]

Lee S; Muniyappa R; Yan X; Chen H; Yue LQ; Hong EG; Kim JK; Quon MJ. 2008. Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab 294(2):E261-70. [PubMed: 18003716]  [MGI Ref ID J:133294]

Lennerz JK; Hurov JB; White LS; Lewandowski KT; Prior JL; Planer GJ; Gereau RW 4th; Piwnica-Worms D; Schmidt RE; Piwnica-Worms H. 2010. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis and defective gluconeogenesis. Mol Cell Biol :. [PubMed: 20733003]  [MGI Ref ID J:163905]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintained as a live colony, heterozygotes may be bred. Homozygotes, although fertile, are somewhat small and females have problems with gestation and lactation; their litter sizes when bred to wildtype males are smaller than normal.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)