Strain Name:

B6;129S-Abl1m1/J

Stock Number:

009412

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Availability:

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Homozygous mice display increased perinatal mortality, runting, increased susceptibility to infection, and abnormal development of the spleen, head and eye. Despite low levels of immature classes of B cells in the bone marrow, homozygotes maintain nearly normal levels of mature functioning B cells. A similar, but less severe defect in T cells is also observed. Cardiac hyperplasia and bone abnormalities are also part of their phenotype.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.129S-Abl1m1/J    (Changed: 28-JUN-12 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHeterozygote x +/+ sibling         (Female x Male)   05-JAN-12
Mating System+/+ sibling x Heterozygote         (Female x Male)   05-JAN-12
Specieslaboratory mouse
Generation+pN1
Generation Definitions
 
Donating Investigator Stephen P. Goff,   Columbia University

Description
Homozygous mice display increased perinatal mortality, runting, increased susceptibility to infection, and abnormal development of the spleen, head and eye. Despite low levels of immature classes of B cells in the bone marrow, homozygotes maintain nearly normal levels of mature functioning B cells. A similar, but less severe defect in T cells is also observed. Cardiac hyperplasia and bone abnormalities are also part of their phenotype. Homozygotes may be born with their eyes open. Testes have the highest expression of the mutant allele, and their protein lacks kinase activity. Heterozygotes show no growth or developmental defects, and both males and females are fertile.

Development
A promoterless neomycin resistance cassette was introduced downstream of the protein kinase domain to selectively replace the last one third of the translated protein sequence. 129S/SvEv-Gpic-derived CCE embryonic stem (ES) cells were used to create the mutation. The donating investigator reported that this line was backcrossed to C57BL/6 for 10 generations (see SNP note below).

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. 15 the 27 markers throughout the genome were segregating between B6J and 129, suggesting an incomplete backcross.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Abl1
009416   129S(B6)-Abl1tm1Mlg/J
013225   B6(Cg)-Abl1tm1Goff/J
013224   B6.129P2-Abl1tm2.1Goff/J
009417   B6.129S-Abl1tm1Mlg/J
024286   B6.129S4-Abl1tm1Ajk/J
View Strains carrying other alleles of Abl1     (5 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Abl1m1/Abl1m1

        B6.129-Abl1m1
  • mortality/aging
  • partial perinatal lethality
    • about 90% die perinatally   (MGI Ref ID J:156743)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Abl1m1/Abl1+

        involves: 129S/SvEv
  • normal phenotype
  • no abnormal phenotype detected
    • normal growth and development   (MGI Ref ID J:72519)

Abl1m1/Abl1m1

        either: 129S/SvEv-Abl1m1 or (involves: 129S/SvEv * CD-1) or (involves: 129S/SvEv * C57BL/6 * DBA/2)
  • mortality/aging
  • partial postnatal lethality
    • homozygous growth and development grossly normal through E17   (MGI Ref ID J:14644)
    • 75% of pups die within the first week after birth   (MGI Ref ID J:14644)
  • premature death
    • animals surviving to weaning are highly susceptible to infection   (MGI Ref ID J:14644)
    • only about 15% survive to 6 weeks of age   (MGI Ref ID J:14644)
  • growth/size/body phenotype
  • decreased body weight
    • young pups weigh 30-80% as much as controls   (MGI Ref ID J:14644)
    • low body weight persists through life   (MGI Ref ID J:14644)
  • immune system phenotype
  • abnormal immune system cell morphology   (MGI Ref ID J:14644)
    • abnormal B cell differentiation
      • mature B cell population in bone marrow seems unaffected   (MGI Ref ID J:14644)
      • mature B cell numbers in peripheral blood and lymph nodes are normal   (MGI Ref ID J:14644)
      • decreased immature B cell number
        • depleted by half to 2/3   (MGI Ref ID J:14644)
        • decreased pre-B cell number
          • depleted by half to 2/3 1n bone marrow   (MGI Ref ID J:14644)
          • depletion less severe in the spleen   (MGI Ref ID J:14644)
          • pre-B cell numbers normal in newborn spleen but become reduced over time   (MGI Ref ID J:14644)
      • decreased pro-B cell number
        • severely reduced in number   (MGI Ref ID J:14644)
    • abnormal T cell number   (MGI Ref ID J:14644)
      • decreased single-positive T cell number
        • somewhat reduced CD4+ and CD8+ cells in peripheral blood   (MGI Ref ID J:14644)
      • decreased thymocyte number
        • early thymocyte numbers are sometimes reduced   (MGI Ref ID J:14644)
      • increased single-positive T cell number
        • elevated CD4+ and CD8+ cells in the spleen   (MGI Ref ID J:14644)
  • abnormal immune system organ morphology   (MGI Ref ID J:14644)
    • abnormal spleen morphology
      • round kidney shaped spleens   (MGI Ref ID J:14644)
      • abnormal spleen white pulp morphology
        • white pulp depleted in mice showing extreme B cell depletion   (MGI Ref ID J:14644)
        • abnormal spleen germinal center morphology   (MGI Ref ID J:14644)
      • spleen hypoplasia
        • cell numbers in new born spleens about 50% of controls   (MGI Ref ID J:14644)
    • abnormal thymus morphology
      • involuted thymi frequently found in mice dead at weaning   (MGI Ref ID J:14644)
      • decreased thymocyte number
        • early thymocyte numbers are sometimes reduced   (MGI Ref ID J:14644)
      • thymus cortex hypoplasia
        • in mice dead at weaning   (MGI Ref ID J:14644)
      • thymus hypoplasia
        • small thymus in many newborns   (MGI Ref ID J:14644)
        • 1/3 as many cells as in controls   (MGI Ref ID J:14644)
  • increased susceptibility to infection
    • animals surviving to weaning are highly susceptible to infection   (MGI Ref ID J:14644)
  • skeleton phenotype
  • decreased cranium height
    • slight shortening of the skull   (MGI Ref ID J:14644)
  • vision/eye phenotype
  • cataracts
    • cataracts often develop   (MGI Ref ID J:14644)
  • eyelids open at birth
    • many born with eyes open   (MGI Ref ID J:14644)
    • eyes often become damaged   (MGI Ref ID J:14644)
  • hematopoietic system phenotype
  • abnormal B cell differentiation
    • mature B cell population in bone marrow seems unaffected   (MGI Ref ID J:14644)
    • mature B cell numbers in peripheral blood and lymph nodes are normal   (MGI Ref ID J:14644)
    • decreased immature B cell number
      • depleted by half to 2/3   (MGI Ref ID J:14644)
      • decreased pre-B cell number
        • depleted by half to 2/3 1n bone marrow   (MGI Ref ID J:14644)
        • depletion less severe in the spleen   (MGI Ref ID J:14644)
        • pre-B cell numbers normal in newborn spleen but become reduced over time   (MGI Ref ID J:14644)
    • decreased pro-B cell number
      • severely reduced in number   (MGI Ref ID J:14644)
  • abnormal T cell number   (MGI Ref ID J:14644)
    • decreased single-positive T cell number
      • somewhat reduced CD4+ and CD8+ cells in peripheral blood   (MGI Ref ID J:14644)
    • decreased thymocyte number
      • early thymocyte numbers are sometimes reduced   (MGI Ref ID J:14644)
    • increased single-positive T cell number
      • elevated CD4+ and CD8+ cells in the spleen   (MGI Ref ID J:14644)
  • abnormal spleen morphology
    • round kidney shaped spleens   (MGI Ref ID J:14644)
    • abnormal spleen white pulp morphology
      • white pulp depleted in mice showing extreme B cell depletion   (MGI Ref ID J:14644)
      • abnormal spleen germinal center morphology   (MGI Ref ID J:14644)
    • spleen hypoplasia
      • cell numbers in new born spleens about 50% of controls   (MGI Ref ID J:14644)
  • abnormal thymus morphology
    • involuted thymi frequently found in mice dead at weaning   (MGI Ref ID J:14644)
    • decreased thymocyte number
      • early thymocyte numbers are sometimes reduced   (MGI Ref ID J:14644)
    • thymus cortex hypoplasia
      • in mice dead at weaning   (MGI Ref ID J:14644)
    • thymus hypoplasia
      • small thymus in many newborns   (MGI Ref ID J:14644)
      • 1/3 as many cells as in controls   (MGI Ref ID J:14644)
  • craniofacial phenotype
  • decreased cranium height
    • slight shortening of the skull   (MGI Ref ID J:14644)

Abl1m1/Abl1m1

        involves: 129S/SvEv
  • immune system phenotype
  • abnormal immune system cell morphology
    • response of peripheral blood cells to lipopolysaccharide is about 38% of control response   (MGI Ref ID J:34903)
    • response of peripheral blood cells to "conA" is reduced to about 18% of control response   (MGI Ref ID J:34903)
    • abnormal B cell differentiation
      • severe depletion becomes more common in mutants over 10 weeks of age   (MGI Ref ID J:28795)
      • decreased pre-B cell number
        • almost completely depleted in bone marrow at 2 months of age   (MGI Ref ID J:28795)
        • overall levels at 63% of controls   (MGI Ref ID J:28795)
      • decreased pro-B cell number
        • CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age   (MGI Ref ID J:28795)
        • 77% of control levels overall   (MGI Ref ID J:28795)
    • decreased mature B cell number
      • B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age   (MGI Ref ID J:28795)
      • levels reduced overall to 67% of controls   (MGI Ref ID J:28795)
  • abnormal splenocyte physiology
    • spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers   (MGI Ref ID J:34903)
    • reduced spleen response to anti-IgM   (MGI Ref ID J:34903)
  • hematopoietic system phenotype
  • abnormal B cell differentiation
    • severe depletion becomes more common in mutants over 10 weeks of age   (MGI Ref ID J:28795)
    • decreased pre-B cell number
      • almost completely depleted in bone marrow at 2 months of age   (MGI Ref ID J:28795)
      • overall levels at 63% of controls   (MGI Ref ID J:28795)
    • decreased pro-B cell number
      • CD43+,B220+ pro-B cells are reduced by 55% in bone marrow at 2 months of age   (MGI Ref ID J:28795)
      • 77% of control levels overall   (MGI Ref ID J:28795)
  • abnormal bone marrow cell physiology
    • bone marrow cell response to Il7 is elevated in young animals and reduced in older ones   (MGI Ref ID J:28795)
  • abnormal splenocyte physiology
    • spleen cell response to lipopolysaccharides is about 10% that of controls, correcting for reduced B cell numbers   (MGI Ref ID J:34903)
    • reduced spleen response to anti-IgM   (MGI Ref ID J:34903)
  • decreased mature B cell number
    • B220+,IgM+ B cells reduced to about 46% of controls in bone marrow at 2 months of age   (MGI Ref ID J:28795)
    • levels reduced overall to 67% of controls   (MGI Ref ID J:28795)

Abl1m1/Abl1m1

        involves: 129S/SvEv * C57BL/6
  • immune system phenotype
  • abnormal B cell physiology
    • calcium flux response to CD19 cross linking is absent   (MGI Ref ID J:148105)
  • abnormal lymphopoiesis
    • common lymphoid progenitors are dramatically reduced in number   (MGI Ref ID J:148105)
    • decreased pro-B cell number
      • "fraction A" pro-B-cells are dramatically reduced in number   (MGI Ref ID J:148105)
  • hematopoietic system phenotype
  • abnormal B cell physiology
    • calcium flux response to CD19 cross linking is absent   (MGI Ref ID J:148105)
  • abnormal bone marrow cell physiology
    • bone marrow cell response to Il7 is elevated   (MGI Ref ID J:148105)
  • abnormal lymphopoiesis
    • common lymphoid progenitors are dramatically reduced in number   (MGI Ref ID J:148105)
    • decreased pro-B cell number
      • "fraction A" pro-B-cells are dramatically reduced in number   (MGI Ref ID J:148105)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
      Growth Defects (homozygous)
Internal/Organ Defects
      heart
      spleen: GI
Perinatal Lethality
      Homozygous
Skeletal Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      B and T cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Abl1m1
Allele Name Abelson leukemia oncogene m1
Allele Type Targeted (knock-out)
Common Name(s) ablm1;
Mutation Made By Stephen Goff,   Columbia University
Strain of Origin129S/SvEv-Gpi1
Gene Symbol and Name Abl1, c-abl oncogene 1, non-receptor tyrosine kinase
Chromosome 2
Gene Common Name(s) ABL; AI325092; E430008G22Rik; JTK7; RIKEN cDNA E430008G22 gene; bcr/abl; c-ABL; c-ABL1; expressed sequence AI325092; p150; v-abl;
Molecular Note A promoterless neomycin resistance gene was inserted into coding sequences corresponding to the carboxy terminus of the protein, downstream of the tyrosine kinase domain and nuclear targeting sequences. This allele expresses a protein with a functional kinase domain but a disrupted carboxy terminus containing the DNA and actin binding domains. [MGI Ref ID J:72518]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Schwartzberg PL; Goff SP; Robertson EJ. 1989. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246(4931):799-803. [PubMed: 2554496]  [MGI Ref ID J:72519]

Additional References

Abl1m1 related

Brightbill H; Schlissel MS. 2009. The effects of c-Abl mutation on developing B cell differentiation and survival. Int Immunol 21(5):575-85. [PubMed: 19299624]  [MGI Ref ID J:148105]

Chen A; Lee SM; Gao B; Shannon S; Zhu Z; Fang D. 2011. c-Abl-Mediated Tyrosine Phosphorylation of the T-bet DNA-Binding Domain Regulates CD4+ T-Cell Differentiation and Allergic Lung Inflammation. Mol Cell Biol 31(16):3445-56. [PubMed: 21690296]  [MGI Ref ID J:175086]

Hardin JD; Boast S; Schwartzberg PL; Lee G; Alt FW; Stall AM; Goff SP. 1996. Abnormal peripheral lymphocyte function in c-abl mutant mice. Cell Immunol 172(1):100-7. [PubMed: 8806812]  [MGI Ref ID J:34903]

Hardin JD; Boast S; Schwartzberg PL; Lee G; Alt FW; Stall AM; Goff SP. 1995. Bone marrow B lymphocyte development in c-abl-deficient mice. Cell Immunol 165(1):44-54. [PubMed: 7671324]  [MGI Ref ID J:28795]

Qiu Z; Cang Y; Goff SP. 2010. c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A 107(3):1136-41. [PubMed: 20080568]  [MGI Ref ID J:156743]

Scherthan H; Jerratsch M; Dhar S; Wang YA; Goff SP; Pandita TK. 2000. Meiotic telomere distribution and sertoli cell nuclear architecture are altered in atm- and atm-p53-deficient mice Mol Cell Biol 20(20):7773-83. [PubMed: 11003672]  [MGI Ref ID J:64777]

Schwartzberg PL; Robertson EJ; Goff SP. 1990. Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein. Proc Natl Acad Sci U S A 87(8):3210-4. [PubMed: 2183226]  [MGI Ref ID J:72518]

Schwartzberg PL; Stall AM; Hardin JD; Bowdish KS; Humaran T; Boast S; Harbison ML; Robertson EJ; Goff SP. 1991. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65(7):1165-75. [PubMed: 2065353]  [MGI Ref ID J:14644]

Wong KK; Hardin JD; Boast S; Cooper CL; Merrell KT; Doyle TG; Goff SP; Calame KL. 1995. A role for c-Abl in c-myc regulation. Oncogene 10(4):705-11. [PubMed: 7862448]  [MGI Ref ID J:23627]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryHeterozygotes show no growth or developmental defects, and both males and females are fertile. Homozygotes show increased perinatal mortality.
Mating SystemHeterozygote x +/+ sibling         (Female x Male)   05-JAN-12
+/+ sibling x Heterozygote         (Female x Male)   05-JAN-12

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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