Strain Name:

B6N.129S1-Tlr3tm1Flv/J

Stock Number:

009675

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Availability:

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Use Restrictions Apply, see Terms of Use
Macrophages derived from these C57BL/6 background toll-like receptor 3 (Tlr3) targeted mutation animals fail to produce inflammatory cytokines, IFN-alpha or IFN-beta when challenged with poly(I:C), polyinosine-polycytidylic acid, a synthetic dsRNA analog. This mutant mouse strain may be useful in studies of the toll-like receptor pathway of the innate immune response.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   22-JAN-11
Specieslaboratory mouse
GenerationN11+F7 (08-APR-13)
Generation Definitions
 
Donating InvestigatorDr. Richard A. Flavell,   Yale University School of Medicine

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Northern blot analysis detects a truncated gene product (mRNA), which is not functional. Unlike wildtype macrophages, macrophages derived from these animals fail to produce inflammatory cytokines, IFN-alpha or IFN-beta when challenged with poly(I:C), polyinosine-polycytidylic acid, a synthetic dsRNA analog. Splenocytes isolated from homozygotes do not respond to viral dsRNA and have diminished IL-6 production. Mice homozygous for the mutation are resistant to poly(I:C) induced shock and produce lower levels of IL-12. This mutant mouse strain may be useful in studies of the toll-like receptor pathway of the innate immune response.

Development
A targeting vector containing a loxP site flanked neomycin resistance cassette and a herpes simplex virus thymidine kinase gene was used to disrupt exon 1. The construct was electroporated into 129S1/Sv-Oca2+ Tyr+ KitlSl-J derived W9.5 embryonic stem (ES) cells. This strain was backcrossed to C57BL/6 from the National Cancer Institute (NCI) ten times by the donating laboratory.

Control Information

  Control
   005304 C57BL/6NJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tlr3tm1Flv allele
005217   B6;129S1-Tlr3tm1Flv/J
022459   C.129S1(B6)-Tlr3tm1Flv/J
View Strains carrying   Tlr3tm1Flv     (2 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Human Immunodeficiency Virus Type 1, Susceptibility to   (TLR3)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tlr3tm1Flv/Tlr3tm1Flv

        involves: C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • upregulation of costimulatory molecules, CD40 and CD86, by peritoneal macrophages in response to dsRNA was preserved on this background   (MGI Ref ID J:86617)
    • abnormal macrophage physiology
      • impaired ability to produce type I interferon and TNF-alpha in response to dsRNA, but not in response to LPS   (MGI Ref ID J:86617)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • impaired ability to produce type I interferon and TNF-alpha in response to dsRNA, but not in response to LPS   (MGI Ref ID J:86617)

Tlr3tm1Flv/Tlr3tm1Flv

        B6.129S1-Tlr3tm1Flv
  • homeostasis/metabolism phenotype
  • abnormal cytokine level
    • reduced cytokine response 8 hours after poly I:C treatment as determined by TNF alpha, IL-6, IL12p40, and IFN-beta   (MGI Ref ID J:129533)
    • abnormal interleukin level
      • IL-13 is upregulated in the lungs after infection with Respiratory syncytial virus   (MGI Ref ID J:126415)
      • IL-5 is upregulated later in the infection response to Respiratory syncytial virus   (MGI Ref ID J:126415)
  • delayed wound healing
    • wound healing of full thickness circular skin opennings are markedly delayed   (MGI Ref ID J:169762)
    • full wound closure around 14 days rather than 12 days as in controls   (MGI Ref ID J:169762)
    • reduced infiltration of neutrophiles at days 1 and 3 and of macrophage at days 3 and 6   (MGI Ref ID J:169762)
    • reduced presence of chemokines involved in leukocyte recruitment   (MGI Ref ID J:169762)
  • respiratory system phenotype
  • abnormal respiratory system physiology
    • increased mucus in the lungs 6 days after infection   (MGI Ref ID J:126415)
    • antibody to IL13 attenuates the mucus response to Respiratory syncytial virus   (MGI Ref ID J:126415)
  • nervous system phenotype
  • abnormal axon morphology
    • number of axons in L1-L5 dorsal roots is unaffected by poly I:C treatment, unlike controls   (MGI Ref ID J:127638)
  • abnormal neuron physiology
    • isolated E14 dorsal root ganglion neurons are resistant to poly I:C inhibition of neurite outgrowth   (MGI Ref ID J:127638)
  • behavior/neurological phenotype
  • altered righting response
    • treatment of mice at 4 days of age has no effect on righting behavior at 9 days of age, unlike controls   (MGI Ref ID J:127638)
  • tumorigenesis
  • increased tumor incidence
    • implanted tumor cells grow larger than in controls   (MGI Ref ID J:158910)
  • immune system phenotype
  • abnormal cytokine level
    • reduced cytokine response 8 hours after poly I:C treatment as determined by TNF alpha, IL-6, IL12p40, and IFN-beta   (MGI Ref ID J:129533)
    • abnormal interleukin level
      • IL-13 is upregulated in the lungs after infection with Respiratory syncytial virus   (MGI Ref ID J:126415)
      • IL-5 is upregulated later in the infection response to Respiratory syncytial virus   (MGI Ref ID J:126415)
  • altered susceptibility to infection
    • viral clearance after infection with Respiratory syncytial virus is unaffected   (MGI Ref ID J:126415)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tlr3tm1Flv/Tlr3tm1Flv

        involves: 129S1/Sv * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype
    • normal lymphocyte development   (MGI Ref ID J:72167)
    • normal expression of CD3, B220, CD4, and CD8 in thymocytes and splenocytes   (MGI Ref ID J:72167)
    • abnormal B cell physiology
      • impaired expression of CD69, CD80, and CD86 in response to poly(I:C), but not LPS   (MGI Ref ID J:72167)
      • impaired expression of CD69 in response to viral genomic dsRNA from Type I Lang mammalian reovirus   (MGI Ref ID J:72167)
    • abnormal macrophage physiology
      • impaired ability to produce IL6, IL12 and TNF-alpha in response to poly(I:C), a synthetic dsRNA analogue   (MGI Ref ID J:72167)
      • production of IL6, IL12, and TNF-alpha in response to LPS, PGN, LTA, zymosan, mannan, or CpG DNA was comparable to wild-type controls   (MGI Ref ID J:72167)
    • decreased inflammatory response
      • resistant to poly(I:C)-induced shock compared to wild-type mice   (MGI Ref ID J:72167)
      • produced less IL12 after poly(I:C) i.p. injection   (MGI Ref ID J:72167)
  • behavior/neurological phenotype
  • abnormal emotion/affect behavior   (MGI Ref ID J:163748)
    • abnormal fear-related response   (MGI Ref ID J:163748)
      • decreased fear-related response
        • less cued fear response to a tone   (MGI Ref ID J:163748)
      • increased fear-related response
        • greater hippocampus dependent contextual fear response, freezing times   (MGI Ref ID J:163748)
    • abnormal response to novel object
      • increased interest in novel objects   (MGI Ref ID J:163748)
    • decreased anxiety-related response
      • in open field tests and elevated + mazes   (MGI Ref ID J:163748)
  • abnormal learning/memory/conditioning   (MGI Ref ID J:163748)
    • abnormal long term spatial reference memory
      • retain memory of platform location in Morris maze tests up to 120 hours compared to 72 hours in controls   (MGI Ref ID J:163748)
    • abnormal spatial working memory
      • enhanced working memory   (MGI Ref ID J:163748)
  • impaired coordination
    • poorer rotarod performance and motor learning   (MGI Ref ID J:163748)
  • nervous system phenotype
  • abnormal dentate gyrus morphology
    • increased in volume   (MGI Ref ID J:163748)
  • abnormal hippocampus CA1 region morphology
    • increased in volume   (MGI Ref ID J:163748)
  • abnormal hippocampus development
    • increased hippocampal neurogenesis   (MGI Ref ID J:163748)
  • cardiovascular system phenotype
  • abnormal vascular wound healing
    • protective effect of poly I:C on neointimal formation is lost   (MGI Ref ID J:169238)
  • homeostasis/metabolism phenotype
  • abnormal vascular wound healing
    • protective effect of poly I:C on neointimal formation is lost   (MGI Ref ID J:169238)
  • hematopoietic system phenotype
  • abnormal B cell physiology
    • impaired expression of CD69, CD80, and CD86 in response to poly(I:C), but not LPS   (MGI Ref ID J:72167)
    • impaired expression of CD69 in response to viral genomic dsRNA from Type I Lang mammalian reovirus   (MGI Ref ID J:72167)
  • abnormal macrophage physiology
    • impaired ability to produce IL6, IL12 and TNF-alpha in response to poly(I:C), a synthetic dsRNA analogue   (MGI Ref ID J:72167)
    • production of IL6, IL12, and TNF-alpha in response to LPS, PGN, LTA, zymosan, mannan, or CpG DNA was comparable to wild-type controls   (MGI Ref ID J:72167)

Tlr3tm1Flv/Tlr3tm1Flv

        Background Not Specified
  • immune system phenotype
  • abnormal NK T cell physiology
    • NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection, however this decrease is not as pronounced as in Tlr9CpG1 or Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)
  • abnormal NK cell physiology
    • NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection, however this decrease is not as pronounced as in Tlr9CpG1 or Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)
  • abnormal cytokine secretion
    • type 1 IFN, IFNgamma and IL-12 p40 levels are decreased compared to C57BL/6 wild-type controls following sublethal viral infection, however this decrease is not as pronounced as in Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)
  • increased susceptibility to viral infection
    • viral loads are significantly higher after mouse cytomegalovirus infection compared to C57BL/6 wild-type controls, however titers are not as high as in Tlr9CpG1 or Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)
  • hematopoietic system phenotype
  • abnormal NK T cell physiology
    • NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection, however this decrease is not as pronounced as in Tlr9CpG1 or Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)
  • abnormal NK cell physiology
    • NK and NK-T cell activation is significantly lower compared to C57BL/6 wild-type controls during mouse cytomegalovirus infection, however this decrease is not as pronounced as in Tlr9CpG1 or Myd88tm1Aki homozygotes   (MGI Ref ID J:88906)

Tlr3tm1Flv/Tlr3tm1Flv

        involves: 129S1/Sv
  • mortality/aging
  • decreased susceptibility to viral infection induced morbidity/mortality
    • in mice infected with rabies virus   (MGI Ref ID J:136330)
  • increased susceptibility to viral infection induced morbidity/mortality
    • decreased survival after infection with Encephalomyocarditis virus   (MGI Ref ID J:119967)
    • severe decline in survival of both homozygotes and heterozygotes after 3 days   (MGI Ref ID J:119967)
    • homozygote deaths continue for 141 days after infection while control and heterozygote deaths level off after 8-10 days   (MGI Ref ID J:119967)
    • higher viral titers in the heart   (MGI Ref ID J:119967)
  • cardiovascular system phenotype
  • heart inflammation
    • higher viral titers of Encephalomyocarditis virus in the hearts of homozygotes   (MGI Ref ID J:119967)
    • less mononuclear cell and T cell infiltration of the myocardium at 3 and 5 days after infection   (MGI Ref ID J:119967)
  • homeostasis/metabolism phenotype
  • abnormal circulating protein level
    • serum levels of cardiac troponin I are elevated indicating myocardial damage   (MGI Ref ID J:119967)
  • abnormal cytokine level   (MGI Ref ID J:119967)
    • abnormal interferon level
      • IFN-beta expression is augmented 3 days after infection   (MGI Ref ID J:119967)
    • abnormal interleukin level
      • expression of IL1beta is delayed until 5 days after infection   (MGI Ref ID J:119967)
      • change in expression is due at least in part due to expression in myocytes   (MGI Ref ID J:119967)
    • abnormal tumor necrosis factor level
      • expression is delayed until 5 days after infection   (MGI Ref ID J:119967)
      • change in expression is due at least in part due to expression in myocyte   (MGI Ref ID J:119967)
  • hyperglycemia
    • higher glycemia in the fed state but normal glucose tolerance   (MGI Ref ID J:135353)
  • immune system phenotype
  • abnormal cytokine level   (MGI Ref ID J:119967)
    • abnormal interferon level
      • IFN-beta expression is augmented 3 days after infection   (MGI Ref ID J:119967)
    • abnormal interleukin level
      • expression of IL1beta is delayed until 5 days after infection   (MGI Ref ID J:119967)
      • change in expression is due at least in part due to expression in myocytes   (MGI Ref ID J:119967)
    • abnormal tumor necrosis factor level
      • expression is delayed until 5 days after infection   (MGI Ref ID J:119967)
      • change in expression is due at least in part due to expression in myocyte   (MGI Ref ID J:119967)
  • decreased susceptibility to viral infection
    • mice infected with rabies virus exhibit improved survival compared with wild-type mice   (MGI Ref ID J:136330)
    • decreased susceptibility to viral infection induced morbidity/mortality
      • in mice infected with rabies virus   (MGI Ref ID J:136330)
  • heart inflammation
    • higher viral titers of Encephalomyocarditis virus in the hearts of homozygotes   (MGI Ref ID J:119967)
    • less mononuclear cell and T cell infiltration of the myocardium at 3 and 5 days after infection   (MGI Ref ID J:119967)
  • increased susceptibility to viral infection induced morbidity/mortality
    • decreased survival after infection with Encephalomyocarditis virus   (MGI Ref ID J:119967)
    • severe decline in survival of both homozygotes and heterozygotes after 3 days   (MGI Ref ID J:119967)
    • homozygote deaths continue for 141 days after infection while control and heterozygote deaths level off after 8-10 days   (MGI Ref ID J:119967)
    • higher viral titers in the heart   (MGI Ref ID J:119967)
  • endocrine/exocrine gland phenotype
  • abnormal pancreatic beta cell physiology
    • isolated beta cells are resistant to apoptosis induced by dsRNA and IFN-gamma or induced by dsRNA and lipofectamine   (MGI Ref ID J:135353)
    • insulin content of beta cells is unaffected by ds RNA whereas content decreases   (MGI Ref ID J:135353)
  • abnormal pancreatic islet morphology   (MGI Ref ID J:148283)
    • decreased pancreatic beta cell mass
      • slightly decreased beta cell mass although the percent volume is increased   (MGI Ref ID J:148283)
    • increased pancreatic islet number   (MGI Ref ID J:148283)
  • reproductive system phenotype
  • abnormal pregnancy
    • intraperitoneal injection of poly I:C fails to induce preterm delivery as it does in controls   (MGI Ref ID J:164980)
    • abnormal postimplantation uterine environment
      • no placental necrosis, hemorrhage or edema after intraperitoneal injection of poly I:C   (MGI Ref ID J:164980)
      • trophoblast fails to secrete cytokines in response to intraperitoneal injection of poly I:C   (MGI Ref ID J:164980)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
Immunodeficiency
      Tlr deficiency
Inflammation
      Tlr deficiency

Tlr3tm1Flv related

Cell Biology Research
Signal Transduction

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
      genes regulating susceptibility to infectious disease and endotoxin
Immunodeficiency Associated with Other Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tlr3tm1Flv
Allele Name targeted mutation 1, Richard A Flavell
Allele Type Targeted (knock-out)
Common Name(s) TLR-; TLR3; Tlr3-;
Mutation Made By Lena Alexopoulou,   Centre d'Immunologie de Marseille-Luminy
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
ES Cell Line NameW9.5/W95
ES Cell Line Strain129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Tlr3, toll-like receptor 3
Chromosome 8
Gene Common Name(s) AI957183; CD283; IIAE2; expressed sequence AI957183;
Molecular Note The gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein. [MGI Ref ID J:72167]

Genotyping

Genotyping Information

Genotyping Protocols

Tlr3tm1Flv, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Alexopoulou L; Holt AC; Medzhitov R; Flavell RA. 2001. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413(6857):732-8. [PubMed: 11607032]  [MGI Ref ID J:72167]

Additional References

Tlr3tm1Flv related

Abe Y; Fujii K; Nagata N; Takeuchi O; Akira S; Oshiumi H; Matsumoto M; Seya T; Koike S. 2012. The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice. J Virol 86(1):185-94. [PubMed: 22072781]  [MGI Ref ID J:178834]

Abston ED; Coronado MJ; Bucek A; Onyimba JA; Brandt JE; Frisancho JA; Kim E; Bedja D; Sung YK; Radtke AJ; Gabrielson KL; Mitzner W; Fairweather D. 2013. TLR3 deficiency induces chronic inflammatory cardiomyopathy in resistant mice following coxsackievirus B3 infection: role for IL-4. Am J Physiol Regul Integr Comp Physiol 304(4):R267-77. [PubMed: 23255589]  [MGI Ref ID J:195232]

Aeffner F; Traylor ZP; Yu EN; Davis IC. 2011. Double-stranded RNA induces similar pulmonary dysfunction to respiratory syncytial virus in BALB/c mice. Am J Physiol Lung Cell Mol Physiol 301(1):L99-L109. [PubMed: 21478252]  [MGI Ref ID J:175954]

Andoniou CE; van Dommelen SL; Voigt V; Andrews DM; Brizard G; Asselin-Paturel C; Delale T; Stacey KJ; Trinchieri G; Degli-Esposti MA. 2005. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol 6(10):1011-9. [PubMed: 16142239]  [MGI Ref ID J:110194]

Bollyky PL; Bice JB; Sweet IR; Falk BA; Gebe JA; Clark AE; Gersuk VH; Aderem A; Hawn TR; Nepom GT. 2009. The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS ONE 4(4):e5063. [PubMed: 19357791]  [MGI Ref ID J:148283]

Bunting RA; Duffy KE; Lamb RJ; San Mateo LR; Smalley K; Raymond H; Liu X; Petley T; Fisher J; Beck H; Flavell RA; Alexopoulou L; Ward CK. 2011. Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro. Cell Immunol 267(1):9-16. [PubMed: 21092943]  [MGI Ref ID J:168591]

Cameron JS; Alexopoulou L; Sloane JA; DiBernardo AB; Ma Y; Kosaras B; Flavell R; Strittmatter SM; Volpe J; Sidman R; Vartanian T. 2007. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J Neurosci 27(47):13033-41. [PubMed: 18032677]  [MGI Ref ID J:127638]

Cao O; Herzog RW. 2008. TLR3 signaling does not affect organ-specific immune responses to factor IX in AAV gene therapy. Blood 112(3):910-1. [PubMed: 18650463]  [MGI Ref ID J:138193]

Cardenas I; Means RE; Aldo P; Koga K; Lang SM; Booth C; Manzur A; Oyarzun E; Romero R; Mor G. 2010. Viral infection of the placenta leads to fetal inflammation and sensitization to bacterial products predisposing to preterm labor. J Immunol 185(2):1248-57. [PubMed: 20554966]  [MGI Ref ID J:165045]

Carpentier PA; Williams BR; Miller SD. 2007. Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli. Glia 55(3):239-52. [PubMed: 17091495]  [MGI Ref ID J:156109]

Cavassani KA; Ishii M; Wen H; Schaller MA; Lincoln PM; Lukacs NW; Hogaboam CM; Kunkel SL. 2008. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 205(11):2609-21. [PubMed: 18838547]  [MGI Ref ID J:141426]

Cavassani KA; Moreira AP; Habiel D; Ito T; Coelho AL; Allen RM; Hu B; Raphelson J; Carson WF 4th; Schaller MA; Lukacs NW; Omary MB; Hogaboam CM; Kunkel SL. 2013. Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. PLoS One 8(6):e65899. [PubMed: 23762449]  [MGI Ref ID J:203310]

Chen S; Sorrentino R; Shimada K; Bulut Y; Doherty TM; Crother TR; Arditi M. 2008. Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol 181(10):7186-93. [PubMed: 18981140]  [MGI Ref ID J:140935]

Chin AI; Miyahira AK; Covarrubias A; Teague J; Guo B; Dempsey PW; Cheng G. 2010. Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance. Cancer Res 70(7):2595-603. [PubMed: 20233880]  [MGI Ref ID J:158910]

Christensen SR; Kashgarian M; Alexopoulou L; Flavell RA; Akira S; Shlomchik MJ. 2005. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 202(2):321-31. [PubMed: 16027240]  [MGI Ref ID J:100530]

Christmann BS; Moran JM; McGraw JA; Buller RM; Corbett JA. 2011. Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. Am J Pathol 179(6):2941-51. [PubMed: 22001348]  [MGI Ref ID J:180065]

Clingan JM; Matloubian M. 2013. B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol 191(2):810-8. [PubMed: 23761632]  [MGI Ref ID J:204821]

Cole JE; Navin TJ; Cross AJ; Goddard ME; Alexopoulou L; Mitra AT; Davies AH; Flavell RA; Feldmann M; Monaco C. 2011. From the Cover: Unexpected protective role for Toll-like receptor 3 in the arterial wall. Proc Natl Acad Sci U S A 108(6):2372-7. [PubMed: 21220319]  [MGI Ref ID J:169238]

Couillin I; Vasseur V; Charron S; Gasse P; Tavernier M; Guillet J; Lagente V; Fick L; Jacobs M; Coelho FR; Moser R; Ryffel B. 2009. IL-1R1/MyD88 signaling is critical for elastase-induced lung inflammation and emphysema. J Immunol 183(12):8195-202. [PubMed: 20007584]  [MGI Ref ID J:157458]

Daffis S; Samuel MA; Suthar MS; Gale M Jr; Diamond MS. 2008. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol 82(21):10349-58. [PubMed: 18715906]  [MGI Ref ID J:153397]

DeWitte-Orr SJ; Collins SE; Bauer CM; Bowdish DM; Mossman KL. 2010. An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses. PLoS Pathog 6(3):e1000829. [PubMed: 20360967]  [MGI Ref ID J:162953]

Delale T; Paquin A; Asselin-Paturel C; Dalod M; Brizard G; Bates EE; Kastner P; Chan S; Akira S; Vicari A; Biron CA; Trinchieri G; Briere F. 2005. MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo. J Immunol 175(10):6723-32. [PubMed: 16272328]  [MGI Ref ID J:119388]

Derbigny WA; Johnson RM; Toomey KS; Ofner S; Jayarapu K. 2010. The Chlamydia muridarum-induced IFN-beta response is TLR3-dependent in murine oviduct epithelial cells. J Immunol 185(11):6689-97. [PubMed: 20974982]  [MGI Ref ID J:167371]

Derbigny WA; Shobe LR; Kamran JC; Toomey KS; Ofner S. 2012. Identifying a Role for Toll-Like Receptor 3 in the Innate Immune Response to Chlamydia muridarum Infection in Murine Oviduct Epithelial Cells. Infect Immun 80(1):254-65. [PubMed: 22006569]  [MGI Ref ID J:178963]

Deshmukh SD; Muller S; Hese K; Rauch KS; Wennekamp J; Takeuchi O; Akira S; Golenbock DT; Henneke P. 2012. NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J Immunol 188(2):774-80. [PubMed: 22184724]  [MGI Ref ID J:180772]

Dogusan Z; Garcia M; Flamez D; Alexopoulou L; Goldman M; Gysemans C; Mathieu C; Libert C; Eizirik DL; Rasschaert J. 2008. Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes 57(5):1236-45. [PubMed: 18223009]  [MGI Ref ID J:135353]

Edelmann KH; Richardson-Burns S; Alexopoulou L; Tyler KL; Flavell RA; Oldstone MB. 2004. Does Toll-like receptor 3 play a biological role in virus infections? Virology 322(2):231-8. [PubMed: 15110521]  [MGI Ref ID J:89374]

Fang J; Fang D; Silver PB; Wen F; Li B; Ren X; Lin Q; Caspi RR; Su SB. 2010. The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model. Invest Ophthalmol Vis Sci 51(6):3092-9. [PubMed: 20107166]  [MGI Ref ID J:164811]

Faul EJ; Wanjalla CN; Suthar MS; Gale M; Wirblich C; Schnell MJ. 2010. Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLoS Pathog 6(7):e1001016. [PubMed: 20661430]  [MGI Ref ID J:167937]

Frazer LC; Sullivan JE; Zurenski MA; Mintus M; Tomasak TE; Prantner D; Nagarajan UM; Darville T. 2013. CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection. J Immunol 191(8):4269-79. [PubMed: 24038087]  [MGI Ref ID J:206277]

Garcia M; Dogusan Z; Moore F; Sato S; Hartmann G; Eizirik DL; Rasschaert J. 2009. Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. Biochim Biophys Acta 1793(11):1768-75. [PubMed: 19747951]  [MGI Ref ID J:164840]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintained as a live colony, homozygotes may be bred.
Mating SystemHomozygote x Homozygote         (Female x Male)   22-JAN-11
Diet Information LabDiet® 5K52/5K67

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Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $195.00Female or MaleHomozygous for Tlr3tm1Flv  
Price per Pair (US dollars $)Pair Genotype
$390.00Homozygous for Tlr3tm1Flv x Homozygous for Tlr3tm1Flv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $253.50Female or MaleHomozygous for Tlr3tm1Flv  
Price per Pair (US dollars $)Pair Genotype
$507.00Homozygous for Tlr3tm1Flv x Homozygous for Tlr3tm1Flv  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   005304 C57BL/6NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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