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| Mice homozygous for the totterer mutation exhibit mild tremors at approximately 2 weeks of age with worsening muscle weakness such that by 6 to 8 weeks of age they display a shaking, limb grasping, hunched, sprawled, tottering walk and develop late-onset clinical paralysis. Premature death results. Homozygotes are poor breeders, reproducing at most once or twice, and females are poor mothers. | |||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6(129P2)-Mpzttrr/GrsrJ (Changed: 02-JUL-09 ) Type Congenic; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N12F7+F18pN1
Generation DefinitionsDescription
Mice homozygous for the totterer mutation exhibit mild tremors at approximately 2 weeks of age with worsening muscle weakness such that by 6 to 8 weeks of age they display a shaking, limb grasping, hunched, sprawled, tottering walk and develop late-onset clinical paralysis. Premature death results. Homozygotes are poor breeders, reproducing at most once or twice, and females are poor mothers.Development
The totterer mutation arose spontaneously in the strain B6.129P2-Nos3tm1Unc/J at The Jackson Laboratory in 2003 when that parental strain was at generation N12F7. This mutant subline has been maintained by sibling inbreeding, and the targeted mutation was bred out.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Phenotype
Phenotype Information
View Mammalian Phenotype Terms
Mammalian Phenotype Terms provided by MGI
assigned by genotype
Mpzttrr/Mpzttrr
B6.Cg-Mpzttrr/GrsrJ
- mortality/aging
- premature death (MGI Ref ID J:149880)
- nervous system phenotype
- demyelination
- homozyogtes assessed from 18 weeks of age through 33 weeks of age show varying degrees and stages of peripheral demyelination (MGI Ref ID J:149880)
- behavior/neurological phenotype
- abnormal gait
- progressive muscle weakness results in a shaking limb grasping, hunched, sprawled, tottering gait by 6 to 8 weeks of age (MGI Ref ID J:149880)
- hindlimb paralysis
- late-onset paralysis of the rear legs (MGI Ref ID J:149880)
- tremors
- mild tremors are first seen at approximately 2 weeks of age (MGI Ref ID J:149880)
- reproductive system phenotype
- infertility
- females and males often fail to breed and those that do breed only breed once or twice (MGI Ref ID J:149880)
Mpzttrr related
Neurobiology Research
Ataxia (Movement) Defects
Neuromuscular Defects
Tremor Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Mpzttrr | ||
|---|---|---|---|
| Allele Name | totterer | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.129P2-Nos3tm1Unc/J | ||
| Gene Symbol and Name | Mpz, myelin protein zero | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; DSS; HMSNIB; MPP; Mpp; P0; peripheral myelin protein; | ||
| Molecular Note | Exon 8 contains a deletion of 4 nucleotides and a duplication of 12 nucleotides, which is predicted to result in multiple amino acid changes at the protein amino terminus. [MGI Ref ID J:149880] | ||
References
References provided by MGI
Selected Reference(s)
Karst SY; Ward-Bailey PF; Samples R; Bergstrom DE; Johnson KR; Donahue LR; Davisson MT. 2009. Totterer: a new mutation in the myelin protein Mpz gene MGI Direct Data Submission :. [MGI Ref ID J:149880]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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