Strain Name:

ISS.ILS-Lore5ILS/TejJ

Stock Number:

010498

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Cryopreserved - Ready for recovery

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Common Names: 5LA;    
This allele of the loss of righting induced by ethanol 5 (Lore5) gene exhibits a 50% increase in the loss righting response time as compared to ISS/TeJ (Inbred Short Sleep). This strain may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names ISS.ILS-Lore5LS/TejJ    (Changed: 16-JUL-09 )
Type Congenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain ISS/IbgTejJ
Donor Strain ILS/IbgTejJ
GenerationN10+F2p
Generation Definitions

Description
This allele of the loss of righting induced by ethanol 5 (Lore5) gene from ILS/TejJ (Inbred Long Sleep) exhibits a 50% increase in the loss of righting response time (LORR)and a decrease in blood ethanol concentration following sedative intraperitoneal ethanol injection on the ISS/TeJ (Inbred Short Sleep) background as compared to the strain ISS/TejJ. This congenic also exhibits an increased ability to maintain body weight under dietary restriction. The congenic interval is believed to include a quantitative trait locus (QTL) for fuel efficiency in response to dietary restriction. This strain may be used to study the genetics of neurogenetic, neuropharmacological, and behavioral phenotypes involved in alcohol-related traits and the genetics of metabolic efficiency.

Development
This congenic strain was developed by backcrossing ILS/Tej to ISS/TeJ for minimum of 10 generations,and then intercrossing to generate a homozygotes. The Lore5 QTL is defined by D15Mit94 to D15Mit14. This strain and the set of ILSXISS recombinant inbreds were donated to The Jackson Laboratory Repository in 2009 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lore5ILS/Lore5ILS

        involves: LS * SS
  • behavior/neurological phenotype
  • impaired righting response
    • increased loss of righting response (LORR) following alcohol challenge   (MGI Ref ID J:76104)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Metabolism Research

Neurobiology Research
Behavioral and Learning Defects

Research Tools
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lore5ILS
Allele Name ILS
Allele Type QTL
Common Name(s) Lore5LS;
Strain of OriginLS or ILS
Gene Symbol and Name Lore5, loss of righting induced by ethanol 5
Chromosome 15
General Note Lore5 exhibits an additive mode of inheritance.
Molecular Note This allele confers increased loss of righting response (LORR) following alcohol challenge compared to SS. [MGI Ref ID J:76104]

Genotyping

Genotyping Information

Genotyping Protocols

D15Mit122, Standard PCR
D15Mit76, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Bennett B; Beeson M; Gordon L; Carosone-Link And P; Johnson TE. 2002. Genetic dissection of quantitative trait Loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Alcohol Clin Exp Res 26(11):1615-24. [PubMed: 12436049]  [MGI Ref ID J:80011]

Bennett B; Beeson M; Gordon L; Johnson TE. 2002. Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 26(2):149-57. [PubMed: 11964553]  [MGI Ref ID J:76104]

Bennett B; Carosone-Link P; Beeson M; Gordon L; Phares-Zook N; Johnson TE. 2008. Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice. Genes Brain Behav 7(6):659-68. [PubMed: 18363857]  [MGI Ref ID J:151159]

Rikke BA; Liao CY; McQueen MB; Nelson JF; Johnson TE. 2010. Genetic dissection of dietary restriction in mice supports the metabolic efficiency model of life extension. Exp Gerontol 45(9):691-701. [PubMed: 20452416]  [MGI Ref ID J:164267]

Lore5ILS related

Bennett B; Beeson M; Gordon L; Carosone-Link And P; Johnson TE. 2002. Genetic dissection of quantitative trait Loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Alcohol Clin Exp Res 26(11):1615-24. [PubMed: 12436049]  [MGI Ref ID J:80011]

Bennett B; Beeson M; Gordon L; Johnson TE. 2002. Reciprocal congenics defining individual quantitative trait Loci for sedative/hypnotic sensitivity to ethanol. Alcohol Clin Exp Res 26(2):149-57. [PubMed: 11964553]  [MGI Ref ID J:76104]

Bennett B; Johnson TE. 1998. Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection. Mamm Genome 9(12):969-74. [PubMed: 9880661]  [MGI Ref ID J:52088]

Proctor WR; Wu PH; Bennett B; Johnson TE. 2004. Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice. Alcohol Clin Exp Res 28(9):1277-83. [PubMed: 15365296]  [MGI Ref ID J:93175]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, this mice are bred as homozygotes.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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