Strain Name:

FVB-Tg(GAS7)63.2Lus/J

Stock Number:

010515

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
These GAS7tg transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Coisogenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Specieslaboratory mouse
 
Donating Investigator Aldons J. Lusis,   University of California at Los Angeles

Description
These transgenic mice express the human growth arrest-specific 7, GAS7, under the direction of the endogenous human gene promoter. Transgene expression is detected in kidney, lung, heart, brain, adipose, liver, but not spleen. The transgene inserted on the X chromosome in tandem. Hemizygous male transgenic mice exhibit decreased fat/lean ratio with lower body weight; decreased gonadal fat pad weight and total fat pad weight; decreased triglycerides, unesterified cholesterol and glucose; and increased total cholesterol and HDL levels. Hemizygous female transgenic mice do not exhibit the decreased fat/lean ratio, but do have decreased mesenteric fat pad weight and reduced unesterified cholesterol. Hemizygous male animals exhibit normal body weight at weaning. This mutant mouse strain may be useful in studies of obesity and lipid metabolism.

Development
A transgenic construct containing the human growth arrest-specific 7, GAS7, (BAC clone RP11-952P13) was injected into fertilized FVB/N mouse eggs. Founder line 63.2 was established. The transgene inserted on the X chromosome in tandem. The strain has been maintained on the FVB/N background.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(GAS7)63.2Lus/Y

        involves: FVB/N
  • growth/size/body phenotype
  • decreased body weight
    • males have significantly decreased body weight   (MGI Ref ID J:148831)
  • adipose tissue phenotype
  • abnormal adipose tissue amount
    • males have a significantly reduced fat/lean ratio (males show increased adiposity relative to females)   (MGI Ref ID J:148831)
    • difference in adiposity is first detected at 11 weeks of age in males   (MGI Ref ID J:148831)
  • decreased gonadal fat pad weight   (MGI Ref ID J:148831)
  • decreased mesenteric fat pad weight
    • observed in females   (MGI Ref ID J:148831)
  • decreased total fat pad weight
    • significant in males   (MGI Ref ID J:148831)
  • homeostasis/metabolism phenotype
  • abnormal cholesterol level
    • significantly reduced unesterified cholesterol level in males and females   (MGI Ref ID J:148831)
    • increased cholesterol level
      • males show significantly increased total cholesterol levels and high-density lipoprotein (HDL) levels   (MGI Ref ID J:148831)
  • decreased circulating glucose level
    • males show reduced glucose levels   (MGI Ref ID J:148831)
  • decreased triglyceride level
    • significantly reduced in males   (MGI Ref ID J:148831)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cardiovascular Research
Hypercholesterolemia

Metabolism Research
Lipid Metabolism

Research Tools
Diabetes and Obesity Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(GAS7)63.2Lus
Allele Name transgene insertion 63.2, Aldons J Lusis
Allele Type Transgenic (random, expressed)
Common Name(s) GAS7tg; GAS7tg;
Mutation Made By Josh Deignan,   UCLA
Strain of OriginFVB/N
Expressed Gene GAS7, growth arrest-specific 7, human
Promoter GAS7, growth arrest-specific 7, human
Molecular Note A transgenic construct containing the human growth arrest-specific 7, GAS7, (BAC clone RP11-952P13) was injected into fertilized FVB/N mouse eggs. Founder line 63.2 was established. The transgene inserted on the X chromosome in tandem. [MGI Ref ID J:148831]
 

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Yang X; Deignan JL; Qi H; Zhu J; Qian S; Zhong J; Torosyan G; Majid S; Falkard B; Kleinhanz RR; Karlsson J; Castellani LW; Mumick S; Wang K; Xie T; Coon M; Zhang C; Estrada-Smith D; Farber CR; Wang SS; van Nas A; Ghazalpour A; Zhang B; Macneil DJ; Lamb JR; Dipple KM; Reitman ML; Mehrabian M; Lum PY; Schadt EE; Lusis AJ; Drake TA. 2009. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet 41(4):415-23. [PubMed: 19270708]  [MGI Ref ID J:148831]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as hemizygotes.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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