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| A tetracycline-responsive element (TRE; tetO) and mouse alpha myosin heavy chain minimal promoter regulate expression of Myc-tagged mouse Dusp6. When these transgenic mice are bred to Myh6-tTA transgenic animals, in the offspring, Dusp6 expression is upregulated in the heart. Transgene expression can be abated in the double transgenic animals with doxycycline administration. | |||||||||||||||||||
Type Coisogenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Jeffery Molkentin, Children's Hospital Medical Center Description
A tetracycline-responsive element (TRE; tetO) and mouse alpha myosin heavy chain minimal promoter regulate expression of Myc-tagged mouse Dusp6. When these transgenic mice are bred to Myh6-tTA transgenic animals, in the offspring, Dusp6 expression is upregulated in the heart. Transgene expression can be abated in the double transgenic animals with doxycycline administration.Development
A tetracycline-responsive element (TRE; tetO) and mouse alpha myosin heavy chain minimal promoter regulate expression of Myc-tagged mouse Dusp6. The transgenic line was created and maintained on an FVB background by the donating laboratory. This is the "medium-expressing" line; copy number was not determined.
Strains carrying other alleles of Dusp6
009069 B6;129X1-Dusp6tm1Jmol/J View Strains carrying other alleles of Dusp6 (1 strain)
Strains carrying other alleles of tetO
View Strains carrying other alleles of tetO (36 strains)
Tet Expression Systems
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
Cardiovascular Research
Tet Expression Systems
tTA/rtTA Responsive Strains
| Allele Symbol | Tg(tetO-Dusp6)1Jmol | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Jeffery D Molkentin | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | Tg(DUSP6); | ||
| Mutation Made By | Jeffery Molkentin, Children's Hospital Medical Center | ||
| Strain of Origin | FVB/N | ||
| Expressed Gene | Dusp6, dual specificity phosphatase 6, mouse, laboratory | ||
| Promoter | tetO, tet operator, | ||
| Molecular Note | A tetracycline-responsive element (TRE; tetO) and mouse alpha myosin heavy chain minimal promoter regulate expression of Myc-tagged mouse Dusp6. The transgenic line was created and maintained on an FVB background. Copy number was not determined. [MGI Ref ID J:124903] | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Purcell NH; Wilkins BJ; York A; Saba-El-Leil MK; Meloche S; Robbins J; Molkentin JD. 2007. Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A 104(35):14074-9. [PubMed: 17709754] [MGI Ref ID J:124903]
Colony Maintenance
Breeding & Husbandry When maintained as a live colony, hemizygotes may be bred.
This strain is currently Under Development for Cryo.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
View All Strains Under Development and On Hold
| Standard Supply | Under Development for Cryopreservation Repository |
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| Supply Notes |
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