Strain Name:

NOD.Cg-B2mtm1Unc Prkdcscid Il2rgtm1Wjl/SzJ

Stock Number:

010636

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: NOD-scid Il2rg<null> B2m<null>;     NOD-scid gamma B2m;     NSG B2m;    
These NOD scid Il2rynull B2mnull triple mutant mice combine the features of the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency, and the MHC class I molecule (beta-2 microglobulin) deficiency and are relatively resistant to graft versus host disease (GVHD). They provide a model useful to study in vivo mechanisms of xenogeneic GVHD and to rapidly assess therapeutic agents.

Description

Strain Information

Former Names NOD.Cg-Prkdcscid B2mtm1Unc Il2rgtm1Wjl/SzJ    (Changed: 07-FEB-12 )
Type Congenic; Mutant Strain; Spontaneous Mutation; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   20-JAN-10
Specieslaboratory mouse
Background Strain NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
Donor Strain NOD/LtSz-B2mtm1Unc Prkdcscid
H2 Haplotypeg7
GenerationN8+N1F14 (27-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Leonard D. Shultz,   The Jackson Laboratory

Appearance
albino

Related Genotype: A/A Tyrc/Tyrc

Description
The NOD.Cg-Prkdcscid B2mtm1Unc Il2rgtm1Wjl/SzJ mice, commonly known as NOD-scid Il2rynull B2m null (NSG-B2m), do not express the Prkdc gene, the X-linked Il2rg gene nor the B2m gene. Triple mutant mice are viable, normal in size and do not display any gross physical or behavioral abnormalities, but can be poor breeders. Mutant mice combine the features of the NOD/ShiLtJ background, the severe combined immune deficiency mutation (scid), IL2 receptor gamma chain deficiency and the MHC class I molecule, beta-2 microglobulin, deficiency and are relatively resistant to graft versus host disease (GVHD). The mean survival time (MST) of NOD-scid Il2rynull B2mnull irradiated with 2 Gy and injected with 5 x 106 human peripheral blood mononuclear cells (PBMC) is 44 days compared to the MST of 21 days in the NOD-scid Il2rynull treated similarly. The blood of GVHD affected NOD-scid Il2rynull B2mnull animals exhibited decreased human CD45+ cell engraftment and significantly higher CD4:Cd8 ratios in spleen and bone marrow when compared with GVHD affected NOD-scid Il2rynull. This model may be useful to study in vivo mechanisms of xenogeneic graft versus host disease and to rapidly assess therapeutic agents.

Please note that this strain carries the true null interleukin-2 receptor gamma chain mutation and should not be confused with other strains that express a truncated interleukin-2 receptor gamma chain as described in: "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain" Ohbo K, et al. Blood 1996. 87:956-67.

Development
Triple mutant mice were produced by breeding NOD/LtSz-Prkdcscid B2mtm1Unc/Sz (Stock No. 003449) mice with NOD.Cg-Prkdcscid Il2rgtm1Wjl/Sz (Stock No. 5557) mice. The resulting mice were interbred to produce mice homozygous for the Prkdcscid and B2mtm1Unc alleles and homozygous (females) or hemizygous (males) for the X-linked Il2rgtm1Wjl allele. The T1DR received this stock in 2009.

Control Information

  Control
   001303 NOD.CB17-Prkdcscid/J
   005557 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   B2mtm1Unc     (22 strains)

View Strains carrying   Il2rgtm1Wjl     (16 strains)

Strains carrying   Prkdcscid allele
018018   B10ScSn.Cg-Prkdcscid Dmdmdx/J
001913   B6.CB17-Prkdcscid/SzJ
017917   B6.Cg-Dysfprmd Prkdcscid/J
021146   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(CAG-FCGRT)276Dcr/DcrJ
018441   B6.Cg-Fcgrttm1Dcr Prkdcscid Tg(FCGRT)32Dcr/DcrJ
018541   B6.Cg-Fcgrttm1Dcr Prkdcscid/DcrJ
010816   B6;C-Ghrhrlit Prkdcscid/BmJ
001131   C3SnSmn.CB17-Prkdcscid/J
001803   CBySmn.CB17-Prkdcscid/J
004083   NOD.129(B6)-Prkdcscid Iduatm1Clk/J
001303   NOD.CB17-Prkdcscid/J
002571   NOD.Cg Prkdcscid-B2mb/Dvs
004644   NOD.Cg Prkdcscid-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJ
005345   NOD.Cg-Cd38tm1Lnd Prkdcscid/LtJ
004262   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/Dvs
012478   NOD.Cg-Prkdcscid Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckJ
004346   NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ
004230   NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ
003843   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)1Lt/LtJ
003844   NOD.Cg-Prkdcscid Tg(Ins2-GAD2)2Lt/LtJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
016148   NOD.Cg-Prkdcscid Alox15tm1Fun/NadlJ
002570   NOD.Cg-Prkdcscid B2mtm1Unc/J
006605   NOD.Cg-Prkdcscid Emv30b Tg(HLA-A/H2-D/B2M)1Dvs/DvsJ
002313   NOD.Cg-Prkdcscid Emv30b/Dvs
005053   NOD.Cg-Prkdcscid Gusbmps/SndsJ
004606   NOD.Cg-Prkdcscid H2-Ab1tm1Doi Tg(HLA-DQA1,HLA-DQB1)1Dv/SzJ
005589   NOD.Cg-Prkdcscid H2-Ab1tm1Doi/SzJ
021885   NOD.Cg-Prkdcscid H2-Ab1tm1Gru Il2rgtm1Wjl/SzJ
014570   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A/H2-D/B2M)1Dvs/SzJ
012479   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-DRA*0101,HLA-DRB1*0101)1Dmz/GckRolyJ
017637   NOD.Cg-Prkdcscid Il2rgtm1Wjl H2-Ab1tm1Gru Tg(HLA-DRB1)31Dmz/SzJ
012480   NOD.Cg-Prkdcscid Il2rgtm1Wjl Hprtb-m3/EshJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
013062   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CMV-IL3,CSF2,KITLG)1Eav/MloySzJ
009617   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(HLA-A2.1)1Enge/SzJ
017830   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(PGK1-KITLG*220)441Daw/SzJ
005557   NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
011066   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy/YgyJGckRolyJ
017620   NOD.Cg-Prkdcscid Tg(CAG-DsRed*MST)1Nagy/KupwJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
006609   NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/DvsJ
007840   NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ
002380   NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ
022396   NOR.CB17(NOD)-Prkdcscid/JsdJ
014543   STOCK Hgftm1.1(HGF)Aveo Prkdcscid/J
010605   STOCK Prkdcscid Gnrh1hpg/BmJ
View Strains carrying   Prkdcscid     (47 strains)

Strains carrying other alleles of B2m
000422   B10.LP-H3b H13b/(36NS)Sn
000421   B10.LP-H3b/Sn
002571   NOD.Cg Prkdcscid-B2mb/Dvs
008542   NOD.Cg-B2mtm1Unc Tg(GFAP-B2m)9Mdos/J
View Strains carrying other alleles of B2m     (4 strains)

View Strains carrying other alleles of Il2rg     (10 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Combined Immunodeficiency, X-Linked; CIDX   (IL2RG)
Hypoproteinemia, Hypercatabolic   (B2M)
Severe Combined Immunodeficiency, X-Linked; SCIDX1   (IL2RG)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Graft vs. Host Disease

Research Tools
Immunology, Inflammation and Autoimmunity Research
      B, T, and NK cell deficiency
Toxicology Research
      B and T cell deficiency, xenograft transplant host

B2mtm1Unc related

Hematological Research
Anemia, Iron Deficiency and Transport Defects
      hemochromatosis

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      MHC class I deficiency

Internal/Organ Research
Liver Defects
      hemochromatosis

Metabolism Research
Hemochromatosis
      iron metabolism defects

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class I deficiency

Il2rgtm1Wjl related

Cancer Research
Growth Factors/Receptors/Cytokines

Immunology, Inflammation and Autoimmunity Research
Growth Factors/Receptors/Cytokines

Prkdcscid related
Immunodeficiency
      B and T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency

Research Tools
Cancer Research
      B and T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Virology Research
B and T Cell Deficiency
      AIDS research tool

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol B2mtm1Unc
Allele Name targeted mutation 1, University of North Carolina
Allele Type Targeted (knock-out)
Common Name(s) I0; MHC-I-; b2mnull; beta2-m-KO; beta2M-; beta2MKO; beta2m0; beta2mnull; beta2mo; beta2mtm1Unc;
Mutation Made ByDr. Oliver Smithies,   University of North Carolina
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name B2m, beta-2 microglobulin
Chromosome 2
Gene Common Name(s) Ly-m11; beta 2 microglobulin; beta2-m; lymphocyte antigen m11;
General Note Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease (J:51450)
Molecular Note Insertion of a neomycin-resistance gene into the second exon. [MGI Ref ID J:65612]
 
Allele Symbol Il2rgtm1Wjl
Allele Name targeted mutation 1, Warren J Leonard
Allele Type Targeted (knock-out)
Common Name(s) CD132-; IL2Rgammanull; Il2rgtm1Wjll; [KO]gammac; gammac-; gc-;
Mutation Made ByDr. Warren Leonard,   NHLBI, NIH
Strain of Origin129S4/SvJae
ES Cell Line NameJ1
ES Cell Line Strain129S4/SvJae
Gene Symbol and Name Il2rg, interleukin 2 receptor, gamma chain
Chromosome X
Gene Common Name(s) Ab2-183; CD132; CIDX; IL-2RG; IMD4; P64; SCIDX; SCIDX1; [g]c; common cytokine receptor gamma chain; common gamma chain; gamma C receptor; gamma(c); gc;
Molecular Note A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. [MGI Ref ID J:24117]
 
Allele Symbol Prkdcscid
Allele Name severe combined immunodeficiency
Allele Type Spontaneous
Common Name(s) SCID;
Strain of OriginC.B-17
Gene Symbol and Name Prkdc, protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Gene Common Name(s) AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; XRCC7; doxorubicin nephropathy; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip;
Molecular Note A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon. [MGI Ref ID J:35393] [MGI Ref ID J:39329]

Genotyping

Genotyping Information

Genotyping Protocols

Prkdcscid End Point, End Point Analysis
B2mtm1Unc, Melt Curve Analysis
Il2rgtm1Wjl, Separated PCR
Il2rgtm1Wjl, Standard PCR
Prkdcscid, Pyrosequencing


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

King MA; Covassin L; Brehm MA; Racki W; Pearson T; Leif J; Laning J; Fodor W; Foreman O; Burzenski L; Chase TH; Gott B; Rossini AA; Bortell R; Shultz LD; Greiner DL. 2009. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 157(1):104-18. [PubMed: 19659776]  [MGI Ref ID J:151390]

Additional References

B2mtm1Unc related

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. Blood 116(12):2103-11. [PubMed: 20554971]  [MGI Ref ID J:164507]

Aguado E; Richelme S; Nunez-Cruz S; Miazek A; Mura AM; Richelme M; Guo XJ; Sainty D; He HT; Malissen B; Malissen M. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296(5575):2036-40. [PubMed: 12065839]  [MGI Ref ID J:77098]

Albu DI; Vanvalkenburgh J; Morin N; Califano D; Jenkins NA; Copeland NG; Liu P; Avram D. 2011. Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes. Proc Natl Acad Sci U S A 108(15):6211-6. [PubMed: 21444811]  [MGI Ref ID J:171277]

Aldrich CJ; Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Forman J. 1994. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A 91(14):6525-8. [PubMed: 8022816]  [MGI Ref ID J:19192]

Alli R; Nguyen P; Boyd K; Sundberg JP; Geiger TL. 2012. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86. [PubMed: 22116824]  [MGI Ref ID J:180590]

Alsharifi M; Lobigs M; Simon MM; Kersten A; Muller K; Koskinen A; Lee E; Mullbacher A. 2006. NK cell-mediated immunopathology during an acute viral infection of the CNS. Eur J Immunol 36(4):887-96. [PubMed: 16541469]  [MGI Ref ID J:114787]

Antal Z; Baker JC; Smith C; Jarchum I; Babad J; Mukherjee G; Yang Y; Sidney J; Sette A; Santamaria P; DiLorenzo TP. 2012. Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol 188(11):5766-75. [PubMed: 22539795]  [MGI Ref ID J:188404]

Apasov S; Sitkovsky M. 1993. Highly lytic CD8+, alpha beta T-cell receptor cytotoxic T cells with major histocompatibility complex (MHC) class I antigen-directed cytotoxicity in beta 2-microglobulin, MHC class I-deficient mice. Proc Natl Acad Sci U S A 90(7):2837-41. [PubMed: 8464897]  [MGI Ref ID J:4360]

Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011]  [MGI Ref ID J:88200]

Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J Immunol 165(7):3673-9. [PubMed: 11034371]  [MGI Ref ID J:118029]

Azuara V; Lembezat MP; Pereira P. 1998. The homogeneity of the TCRdelta repertoire expressed by the Thy-1dull gammadelta T cell population is due to cellular selection. Eur J Immunol 28(11):3456-67. [PubMed: 9842888]  [MGI Ref ID J:51177]

Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. [PubMed: 9686607]  [MGI Ref ID J:49819]

Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bain G; Quong MW; Soloff RS; Hedrick SM; Murre C. 1999. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med 190(11):1605-16. [PubMed: 10587351]  [MGI Ref ID J:58800]

Baldwin SL; Ching LK; Pine SO; Moutaftsi M; Lucas E; Vallur A; Orr MT; Bertholet S; Reed SG; Coler RN. 2013. Protection against tuberculosis with homologous or heterologous protein/vector vaccine approaches is not dependent on CD8+ T cells. J Immunol 191(5):2514-25. [PubMed: 23904160]  [MGI Ref ID J:205818]

Bannai M; Kawamura T; Naito T; Kameyama H; Abe T; Kawamura H; Tsukada C; Watanabe H; Hatakeyama K; Hamada H; Nishiyama Y; Ishikawa H; Takeda K; Okumura K; Taniguchi M; Abo T. 2001. Abundance of unconventional CD8(+) natural killer T cells in the large intestine. Eur J Immunol 31(11):3361-9. [PubMed: 11745354]  [MGI Ref ID J:72615]

Bard J; Yamazaki K; Curran M; Boyse EA; Beauchamp GK. 2000. Effect of B2m gene disruption on MHC-determined odortypes. Immunogenetics 51(7):514-8. [PubMed: 10912502]  [MGI Ref ID J:63063]

Basha G; Omilusik K; Chavez-Steenbock A; Reinicke AT; Lack N; Choi KB; Jefferies WA. 2012. A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol 13(3):237-245. [PubMed: 22306692]  [MGI Ref ID J:181327]

Beauvillain C; Delneste Y; Scotet M; Peres A; Gascan H; Guermonprez P; Barnaba V; Jeannin P. 2007. Neutrophils efficiently cross-prime naive T cells in vivo. Blood 110(8):2965-73. [PubMed: 17562875]  [MGI Ref ID J:148908]

Behrens EM; Canna SW; Slade K; Rao S; Kreiger PA; Paessler M; Kambayashi T; Koretzky GA. 2011. Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice. J Clin Invest 121(6):2264-77. [PubMed: 21576823]  [MGI Ref ID J:173903]

Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578]  [MGI Ref ID J:101693]

Belanger S; Tu MM; Rahim MM; Mahmoud AB; Patel R; Tai LH; Troke AD; Wilhelm BT; Landry JR; Zhu Q; Tung KS; Raulet DH; Makrigiannis AP. 2012. Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. Blood 120(3):592-602. [PubMed: 22661698]  [MGI Ref ID J:189106]

Bender BS; Croghan T; Zhang L; Small PA Jr. 1992. Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. J Exp Med 175(4):1143-5. [PubMed: 1552285]  [MGI Ref ID J:110598]

Berg RE; Princiotta MF; Irion S; Moticka JA; Dahl KR; Staerz UD. 1999. Positive selection of an H2-M3 restricted T cell receptor. Immunity 11(1):33-43. [PubMed: 10435577]  [MGI Ref ID J:110475]

Bienvenu B; Martin B; Auffray C; Cordier C; Becourt C; Lucas B. 2005. Peripheral CD8+CD25+ T lymphocytes from MHC class II-deficient mice exhibit regulatory activity. J Immunol 175(1):246-53. [PubMed: 15972655]  [MGI Ref ID J:100582]

Birnberg T; Bar-On L; Sapoznikov A; Caton ML; Cervantes-Barragan L; Makia D; Krauthgamer R; Brenner O; Ludewig B; Brockschnieder D; Riethmacher D; Reizis B; Jung S. 2008. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29(6):986-97. [PubMed: 19062318]  [MGI Ref ID J:142682]

Bitsaktsis C; Winslow G. 2006. Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection. J Immunol 177(7):4644-51. [PubMed: 16982903]  [MGI Ref ID J:139316]

Blancou P; Mallone R; Martinuzzi E; Severe S; Pogu S; Novelli G; Bruno G; Charbonnel B; Dolz M; Chaillous L; van Endert P; Bach JM. 2007. Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol 178(11):7458-66. [PubMed: 17513797]  [MGI Ref ID J:147823]

Bonig H; Priestley GV; Oehler V; Papayannopoulou T. 2007. Hematopoietic progenitor cells (HPC) from mobilized peripheral blood display enhanced migration and marrow homing compared to steady-state bone marrow HPC. Exp Hematol 35(2):326-34. [PubMed: 17258081]  [MGI Ref ID J:123189]

Boucherma R; Kridane-Miledi H; Bouziat R; Rasmussen M; Gatard T; Langa-Vives F; Lemercier B; Lim A; Berard M; Benmohamed L; Buus S; Rooke R; Lemonnier FA. 2013. HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses. J Immunol 191(2):583-93. [PubMed: 23776170]  [MGI Ref ID J:205453]

Bowen S; Sun P; Livak F; Sharrow S; Hodes RJ. 2014. A novel T cell subset with trans-rearranged Vgamma-Cbeta TCRs shows Vbeta expression is dispensable for lineage choice and MHC restriction. J Immunol 192(1):169-77. [PubMed: 24307734]  [MGI Ref ID J:207166]

Brawand P; Lemonnier FA; MacDonald HR; Cerottini JC; Held W. 2000. Transgenic expression of Ly49A on T cells impairs a specific antitumor response. J Immunol 165(4):1871-6. [PubMed: 10925266]  [MGI Ref ID J:108611]

Brossay L; Jullien D; Cardell S; Sydora BC; Burdin N; Modlin RL ; Kronenberg M. 1997. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol 159(3):1216-24. [PubMed: 9233616]  [MGI Ref ID J:41641]

Buhlmann JE; Foy TM; Aruffo A; Crassi KM; Ledbetter JA; Green WR; Xu JC; Shultz LD; Roopesian D; Flavell RA; et al.. 1995. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 2(6):645-53. [PubMed: 7540943]  [MGI Ref ID J:189416]

Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. [PubMed: 15688349]  [MGI Ref ID J:96737]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Canonne-Hergaux F; Levy JE; Fleming MD; Montross LK; Andrews NC; Gros P. 2001. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97(4):1138-40. [PubMed: 11159549]  [MGI Ref ID J:67402]

Capone M; Lees RK; Finke D; Ernst B; Meerwijk JP; MacDonald HR. 2003. Selective absence of CD8+ TCRalpha beta+ intestinal epithelial cells in transgenic mice expressing beta2-microglobulin-associated ligands exclusively on thymic cortical epithelium. Eur J Immunol 33(6):1471-7. [PubMed: 12778464]  [MGI Ref ID J:83888]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. [PubMed: 16612374]  [MGI Ref ID J:107629]

Chaise C; Buchan SL; Rice J; Marquet J; Rouard H; Kuentz M; Vittes GE; Molinier-Frenkel V; Farcet JP; Stauss HJ; Delfau-Larue MH; Stevenson FK. 2008. DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance. Blood 112(7):2956-64. [PubMed: 18502835]  [MGI Ref ID J:140153]

Chamero P; Marton TF; Logan DW; Flanagan K; Cruz JR; Saghatelian A; Cravatt BF; Stowers L. 2007. Identification of protein pheromones that promote aggressive behaviour. Nature 450(7171):899-902. [PubMed: 18064011]  [MGI Ref ID J:130465]

Champsaur M; Beilke JN; Ogasawara K; Koszinowski UH; Jonjic S; Lanier LL. 2010. Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1. J Immunol 185(1):157-65. [PubMed: 20530257]  [MGI Ref ID J:161608]

Chan OT; Paliwal V; McNiff JM; Park SH; Bendelac A; Shlomchik MJ. 2001. Deficiency in beta(2)-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Fas(lpr) Mice: An Example of Disease Regulation at the Organ Level. J Immunol 167(5):2985-90. [PubMed: 11509649]  [MGI Ref ID J:71175]

Chan S; Correia-Neves M; Dierich A; Benoist C; Mathis D. 1998. Visualization of CD4/CD8 T cell commitment. J Exp Med 188(12):2321-33. [PubMed: 9858518]  [MGI Ref ID J:113263]

Chan SH; Cosgrove D; Waltzinger C; Benoist C; Mathis D. 1993. Another view of the selective model of thymocyte selection. Cell 73(2):225-36. [PubMed: 8097430]  [MGI Ref ID J:111130]

Chaudhury C; Kim J; Mehnaz S; Wani MA; Oberyszyn TM; Bronson CL; Mohanty S; Hayton WL; Robinson JM; Anderson CL. 2006. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr 136(12):2993-8. [PubMed: 17116709]  [MGI Ref ID J:117735]

Chaudhury C; Mehnaz S; Robinson JM; Hayton WL; Pearl DK; Roopenian DC; Anderson CL. 2003. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197(3):315-22. [PubMed: 12566415]  [MGI Ref ID J:110885]

Chen L; Jay DC; Fairbanks JD; He X; Jensen PE. 2011. An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus. J Immunol 187(12):6463-72. [PubMed: 22084437]  [MGI Ref ID J:180389]

Chen M; Tabaczewski P; Truscott SM; Van Kaer L; Stroynowski I. 2005. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J Immunol 175(2):1047-55. [PubMed: 16002705]  [MGI Ref ID J:100733]

Chen YG; Chen J; Osborne MA; Chapman HD; Besra GS; Porcelli SA; Leiter EH; Wilson SB; Serreze DV. 2006. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol 177(5):2939-47. [PubMed: 16920929]  [MGI Ref ID J:112615]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo MP. 2001. Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases. Eur J Immunol 31(10):3101-10. [PubMed: 11592087]  [MGI Ref ID J:115631]

Chiu NM; Wang B; Kerksiek KM; Kurlander R; Pamer EG; Wang CR. 1999. The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus. J Exp Med 190(12):1869-78. [PubMed: 10601361]  [MGI Ref ID J:131934]

Cho H; Choi HJ; Xu H; Felio K; Wang CR. 2011. Nonconventional CD8+ T cell responses to Listeria infection in mice lacking MHC class Ia and H2-M3. J Immunol 186(1):489-98. [PubMed: 21098224]  [MGI Ref ID J:168008]

Chong SZ; Tan KW; Wong FH; Chua YL; Tang Y; Ng LG; Angeli V; Kemeny DM. 2014. CD8 T Cells Regulate Allergic Contact Dermatitis by Modulating CCR2-Dependent TNF/iNOS-Expressing Ly6C(+)CD11b(+) Monocytic Cells. J Invest Dermatol 134(3):666-76. [PubMed: 24061165]  [MGI Ref ID J:206039]

Christianson GJ; Blankenburg RL; Duffy TM; Panka D; Roths JB; Marshak-Rothstein A; Roopenian DC. 1996. beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol 156(12):4932-9. [PubMed: 8648144]  [MGI Ref ID J:33405]

Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. [PubMed: 9103418]  [MGI Ref ID J:102141]

Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787]  [MGI Ref ID J:34814]

Christopher K; Liang Y; Mueller TF; DeFina R; He H; Haley KJ; Exley MA; Finn PW; Perkins DL. 2004. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation 78(6):788-98. [PubMed: 15385796]  [MGI Ref ID J:98356]

Cogen AL; Moore TA. 2009. Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia. Infect Immun 77(1):360-6. [PubMed: 18981251]  [MGI Ref ID J:143765]

Coles MC; Raulet DH. 1994. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9. [PubMed: 8006596]  [MGI Ref ID J:110734]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Cook JR; Solheim JC; Connolly JM; Hansen TH. 1995. Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice. J Immunol 154(1):47-57. [PubMed: 7995959]  [MGI Ref ID J:22257]

Coppieters KT; Amirian N; von Herrath MG. 2011. Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice. Clin Exp Immunol 165(2):155-62. [PubMed: 21605113]  [MGI Ref ID J:175948]

Corr M; Crain B. 2002. The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol 169(11):6604-9. [PubMed: 12444173]  [MGI Ref ID J:124384]

Coudert JD; Foucras G; Demur C; Coureau C; Mazerolles C; Delsol G; Druet P; Guery JC. 2000. Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions. J Clin Invest 105(8):1125-32. [PubMed: 10772657]  [MGI Ref ID J:120539]

Creusot RJ; Yaghoubi SS; Kodama K; Dang DN; Dang VH; Breckpot K; Thielemans K; Gambhir SS; Fathman CG. 2008. Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol 127(2):176-87. [PubMed: 18337172]  [MGI Ref ID J:133579]

Crow AR; Suppa SJ; Chen X; Mott PJ; Lazarus AH. 2011. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood 118(24):6403-6. [PubMed: 22001393]  [MGI Ref ID J:179078]

Crozat K; Hoebe K; Ugolini S; Hong NA; Janssen E; Rutschmann S; Mudd S; Sovath S; Vivier E; Beutler B. 2007. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J Exp Med 204(4):853-63. [PubMed: 17420270]  [MGI Ref ID J:119974]

D'Orazio TJ; Mayhew E; Niederkorn JY. 2001. Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1 J Immunol 166(1):26-32. [PubMed: 11123273]  [MGI Ref ID J:66404]

D'Souza CD; Cooper AM; Frank AA; Ehlers S; Turner J; Bendelac A; Orme IM. 2000. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am J Respir Cell Mol Biol 23(2):188-93. [PubMed: 10919985]  [MGI Ref ID J:114179]

Dalloul AH; Ngo K; Fung-Leung WP. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur J Immunol 26(1):213-8. [PubMed: 8566069]  [MGI Ref ID J:112982]

Dang Y; Heyborne KD. 2001. Cutting edge: regulation of uterine NKT cells by a fetal class I molecule other than CD1. J Immunol 166(6):3641-4. [PubMed: 11238600]  [MGI Ref ID J:126656]

Daniels MA; Teixeiro E; Gill J; Hausmann B; Roubaty D; Holmberg K; Werlen G; Hollander GA; Gascoigne NR; Palmer E. 2006. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature 444(7120):724-9. [PubMed: 17086201]  [MGI Ref ID J:117478]

Dao T; Exley M; Mehal WZ; Tahir SM; Snapper S; Taniguchi M; Balk SP; Crispe IN. 2001. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol 166(5):3090-7. [PubMed: 11207260]  [MGI Ref ID J:76978]

Das G; Das J; Eynott P; Zhang Y; Bothwell AL; Van Kaer L; Shi Y. 2006. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med 203(12):2603-11. [PubMed: 17088432]  [MGI Ref ID J:124622]

Das G; Janeway CA Jr. 1999. Development of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice. J Exp Med 190(6):881-4. [PubMed: 10499926]  [MGI Ref ID J:57703]

Das G; Sheridan S; Janeway CA Jr. 2001. The source of early IFN-gamma that plays a role in Th1 priming. J Immunol 167(4):2004-10. [PubMed: 11489982]  [MGI Ref ID J:110883]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Deane R; Sagare A; Hamm K; Parisi M; LaRue B; Guo H; Wu Z; Holtzman DM; Zlokovic BV. 2005. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci 25(50):11495-503. [PubMed: 16354907]  [MGI Ref ID J:103998]

Diaz-de-Durana Y; Mantchev GT; Bram RJ; Franco A. 2006. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood 107(2):594-601. [PubMed: 16195331]  [MGI Ref ID J:126637]

Do JS; Min B. 2009. Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo. Proc Natl Acad Sci U S A 106(48):20394-8. [PubMed: 19920180]  [MGI Ref ID J:155564]

Dong Z; Davidson D; Perez-Quintero LA; Kurosaki T; Swat W; Veillette A. 2012. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity 36(6):974-85. [PubMed: 22683124]  [MGI Ref ID J:187430]

Dragovic SM; Hill T; Christianson GJ; Kim S; Elliott T; Scott D; Roopenian DC; Van Kaer L; Joyce S. 2011. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol 186(12):6683-92. [PubMed: 21572029]  [MGI Ref ID J:175483]

Drake DR 3rd; Lukacher AE. 1998. Beta 2-microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis. Virology 252(1):275-84. [PubMed: 9875336]  [MGI Ref ID J:52185]

Dubois A; Deruytter N; Adams B; Kanda A; Delbauve S; Fleury S; Torres D; Francois A; Petein M; Goldman M; Dombrowicz D; Flamand V. 2010. Regulation of Th2 responses and allergic inflammation through bystander activation of CD8+ T lymphocytes in early life. J Immunol 185(2):884-91. [PubMed: 20562264]  [MGI Ref ID J:161925]

Elewaut D; Brossay L; Santee SM; Naidenko OV; Burdin N; De Winter H; Matsuda J; Ware CF; Cheroutre H; Kronenberg M. 2000. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol 165(2):671-9. [PubMed: 10878339]  [MGI Ref ID J:106601]

Elewaut D; Shaikh RB; Hammond KJ; De Winter H; Leishman AJ; Sidobre S; Turovskaya O; Prigozy TI; Ma L; Banks TA; Lo D; Ware CF; Cheroutre H; Kronenberg M. 2003. NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med 197(12):1623-33. [PubMed: 12810685]  [MGI Ref ID J:120659]

Emoto M; Emoto Y; Brinkmann V; Miyamoto M; Yoshizawa I; Staber M; van Rooijen N; Hamann A; Kaufmann SH. 2003. Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. J Immunol 171(2):584-93. [PubMed: 12847222]  [MGI Ref ID J:123460]

Enoh VT; Lin CY; Varma TK; Sherwood ER. 2006. Differential effect of imipenem treatment on injury caused by cecal ligation and puncture in wild-type and NK cell-deficient beta(2)-microgloblin knockout mice. Am J Physiol Gastrointest Liver Physiol 290(2):G277-84. [PubMed: 16166341]  [MGI Ref ID J:106051]

Eppert BL; Wortham BW; Flury JL; Borchers MT. 2013. Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease. J Immunol 190(3):1331-40. [PubMed: 23264660]  [MGI Ref ID J:192605]

Erman B; Guinter TI; Singer A. 2004. Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation. J Exp Med 199(12):1719-24. [PubMed: 15210747]  [MGI Ref ID J:120401]

Escande-Beillard N; Washburn L; Zekzer D; Wu ZP; Eitan S; Ivkovic S; Lu Y; Dang H; Middleton B; Bilousova TV; Yoshimura Y; Evans CJ; Joyce S; Tian J; Kaufman DL. 2010. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol 184(2):816-23. [PubMed: 20018625]  [MGI Ref ID J:159396]

Fahlen L; Lendahl U; Sentman CL. 2001. MHC class I-Ly49 interactions shape the Ly49 repertoire on murine NK cells. J Immunol 166(11):6585-92. [PubMed: 11359811]  [MGI Ref ID J:133137]

Felio K; Nguyen H; Dascher CC; Choi HJ; Li S; Zimmer MI; Colmone A; Moody DB; Brenner MB; Wang CR. 2009. CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice. J Exp Med 206(11):2497-509. [PubMed: 19808251]  [MGI Ref ID J:154072]

Feng N; Kim B; Fenaux M; Nguyen H; Vo P; Omary MB; Greenberg HB. 2008. Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol 82(15):7578-90. [PubMed: 18495762]  [MGI Ref ID J:153415]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Fiette L; Aubert C; Brahic M; Rossi CP. 1993. Theiler's virus infection of beta 2-microglobulin-deficient mice. J Virol 67(1):589-92. [PubMed: 8416386]  [MGI Ref ID J:3649]

Firat H; Tourdot S; Ureta-Vidal A; Scardino A; Suhrbier A; Buseyne F; Riviere Y; Danos O; Michel ML; Kosmatopoulos K; Lemonnier FA. 2001. Design of a polyepitope construct for the induction of HLA-A0201-restricted HIV 1-specific CTL responses using HLA-A*0201 transgenic, H-2 class I KO mice. Eur J Immunol 31(10):3064-74. [PubMed: 11592083]  [MGI Ref ID J:115621]

Flatz L; Rieger T; Merkler D; Bergthaler A; Regen T; Schedensack M; Bestmann L; Verschoor A; Kreutzfeldt M; Bruck W; Hanisch UK; Gunther S; Pinschewer DD. 2010. T cell-dependence of Lassa fever pathogenesis. PLoS Pathog 6(3):e1000836. [PubMed: 20360949]  [MGI Ref ID J:162954]

Flynn JL; Goldstein MM; Triebold KJ; Koller B; Bloom BR. 1992. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 89(24):12013-7. [PubMed: 1465432]  [MGI Ref ID J:111189]

Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. [PubMed: 21266499]  [MGI Ref ID J:168554]

Foucras G; Coudert JD; Coureau C; Guery JC. 2000. Dendritic cells prime in vivo alloreactive CD4 T lymphocytes toward type 2 cytokine- and TGF-beta-producing cells in the absence of CD8 T cell activation. J Immunol 165(9):4994-5003. [PubMed: 11046027]  [MGI Ref ID J:118923]

Freland S; Chambers BJ; Andersson M; Van Kaer L; Ljunggren HG. 1998. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J Immunol 160(2):572-9. [PubMed: 9551890]  [MGI Ref ID J:45189]

Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089]  [MGI Ref ID J:61231]

French JD; Roark CL; Born WK; O'brien RL. 2005. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A 102(41):14741-6. [PubMed: 16203967]  [MGI Ref ID J:102497]

Fritz RB; Zhao ML. 2001. Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cells. J Immunol 166(6):4209-15. [PubMed: 11238673]  [MGI Ref ID J:126134]

Fukui Y; Hashimoto O; Inayoshi A; Gyotoku T; Sano T; Koga T; Gushima T; Sasazuki T. 1998. Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain. J Exp Med 188(5):897-907. [PubMed: 9730891]  [MGI Ref ID J:115130]

Fukui Y; Oono T; Cabaniols JP; Nakao K; Hirokawa K; Inayoshi A; Sanui T; Kanellopoulos J; Iwata E; Noda M; Katsuki M; Kourilsky P; Sasazuki T. 2000. Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. Proc Natl Acad Sci U S A 97(25):13760-5. [PubMed: 11087837]  [MGI Ref ID J:125474]

Gadue P; Morton N; Stein PL. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-96. [PubMed: 10523617]  [MGI Ref ID J:110943]

Gapin L; Cheroutre H; Kronenberg M. 1999. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol 163(8):4100-4. [PubMed: 10510343]  [MGI Ref ID J:111019]

Gasteiger G; Hemmers S; Firth MA; Le Floc'h A; Huse M; Sun JC; Rudensky AY. 2013. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med 210(6):1167-78. [PubMed: 23650441]  [MGI Ref ID J:200961]

Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600]  [MGI Ref ID J:119802]

Ghetie V; Hubbard JG; Kim JK; Tsen MF; Lee Y; Ward ES. 1996. Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 26(3):690-6. [PubMed: 8605939]  [MGI Ref ID J:31992]

Glas R; Ohlen C; Hoglund P; Karre K. 1994. The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J Exp Med 179(2):661-72. [PubMed: 8294874]  [MGI Ref ID J:16604]

Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107(2):199-206. [PubMed: 11160136]  [MGI Ref ID J:66974]

Glynn MW; Elmer BM; Garay PA; Liu XB; Needleman LA; El-Sabeawy F; McAllister AK. 2011. MHCI negatively regulates synapse density during the establishment of cortical connections. Nat Neurosci 14(4):442-51. [PubMed: 21358642]  [MGI Ref ID J:172306]

Gombold JL; Sutherland RM; Lavi E; Paterson Y; Weiss SR. 1995. Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells. Microb Pathog 18(3):211-21. [PubMed: 7565015]  [MGI Ref ID J:127517]

Gonzalez A; Andre-Schmutz I; Carnaud C; Mathis D; Benoist C. 2001. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol 2(12):1117-25. [PubMed: 11713466]  [MGI Ref ID J:109860]

Graf D; Nethisinghe S; Palmer DB; Fisher AG; Merkenschlager M. 2002. The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med 196(2):163-71. [PubMed: 12119341]  [MGI Ref ID J:120461]

Grange RW; Gainer TG; Marschner KM; Talmadge RJ; Stull JT. 2002. Fast-twitch skeletal muscles of dystrophic mouse pups are resistant to injury from acute mechanical stress. Am J Physiol Cell Physiol 283(4):C1090-101. [PubMed: 12225973]  [MGI Ref ID J:107767]

Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754]  [MGI Ref ID J:93553]

Gritzapis AD; Mahaira LG; Perez SA; Cacoullos NT; Papamichail M; Baxevanis CN. 2006. Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo. Cancer Res 66(10):5452-60. [PubMed: 16707474]  [MGI Ref ID J:109050]

Gruber A; Cannarile MA; Cheminay C; Ried C; Marconi P; Hacker G; Brocker T. 2010. Parenchymal cells critically curtail cytotoxic T-cell responses by inducing Bim-mediated apoptosis. Eur J Immunol 40(4):966-75. [PubMed: 20127674]  [MGI Ref ID J:159191]

Grubin CE; Kovats S; deRoos P; Rudensky AY. 1997. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7(2):197-208. [PubMed: 9285405]  [MGI Ref ID J:84193]

Guery JC; Galbiati F; Smiroldo S; Adorini L. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J Exp Med 183(2):485-97. [PubMed: 8627161]  [MGI Ref ID J:31311]

Guimond MJ; Luross JA; Wang B; Terhorst C; Danial S; Croy BA. 1997. Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice. Biol Reprod 56(1):169-79. [PubMed: 9002646]  [MGI Ref ID J:134589]

Guleria I; Gubbels Bupp M; Dada S; Fife B; Tang Q; Ansari MJ; Trikudanathan S; Vadivel N; Fiorina P; Yagita H; Azuma M; Atkinson M; Bluestone JA; Sayegh MH. 2007. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol 125(1):16-25. [PubMed: 17627890]  [MGI Ref ID J:125272]

Hamilton-Williams EE; Serreze DV; Charlton B; Johnson EA; Marron MP; Mullbacher A; Slattery RM. 2001. Transgenic rescue implicates beta 2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A 98(20):11533-8. [PubMed: 11572996]  [MGI Ref ID J:71837]

Hancock WW; Tsai TL; Madaio MP; Gasser DL. 2003. Cutting Edge: Multiple autoimmune pathways in kd/kd mice. J Immunol 171(6):2778-81. [PubMed: 12960297]  [MGI Ref ID J:85380]

Hausmann J; Pagenstecher A; Baur K; Richter K; Rziha HJ; Staeheli P. 2005. CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79(21):13509-18. [PubMed: 16227271]  [MGI Ref ID J:102183]

Hayakawa Y; Watt SV; Takeda K; Smyth MJ. 2008. Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression. J Leukoc Biol 83(1):106-11. [PubMed: 17940219]  [MGI Ref ID J:130091]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

He X; Park K; Wang H; He X; Zhang Y; Hua X; Li Y; Kappes DJ. 2008. CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity 28(3):346-58. [PubMed: 18342007]  [MGI Ref ID J:132996]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553]  [MGI Ref ID J:118863]

Hikosaka Y; Nitta T; Ohigashi I; Yano K; Ishimaru N; Hayashi Y; Matsumoto M; Matsuo K; Penninger JM; Takayanagi H; Yokota Y; Yamada H; Yoshikai Y; Inoue J; Akiyama T; Takahama Y. 2008. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity 29(3):438-50. [PubMed: 18799150]  [MGI Ref ID J:139648]

Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80. [PubMed: 12689924]  [MGI Ref ID J:163372]

Hirayama M; Genyea C; Kaplan J. 1996. Natural killer cell recognition of self and non-self triggering antigens on normal lymphoblasts. Cell Immunol 173(1):33-48. [PubMed: 8871599]  [MGI Ref ID J:35841]

Hobbs NK; Bondareva AA; Barnett S; Capecchi MR; Schmidt EE. 2002. Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental beta2m-Dependent Interactions with the Maternal Immune System. Cell 110(1):43-54. [PubMed: 12150996]  [MGI Ref ID J:77714]

Hoglund P; Glas R; Menard C; Kase A; Johansson MH; Franksson L; Lemmonier F; Karre K. 1998. Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains. Eur J Immunol 28(1):370-8. [PubMed: 9485216]  [MGI Ref ID J:45905]

Hogquist KA; Gavin MA; Bevan MJ. 1993. Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture. J Exp Med 177(5):1469-73. [PubMed: 8478616]  [MGI Ref ID J:77013]

Hsieh SH; Lin JS; Huang JH; Wu SY; Chu CL; Kung JT; Wu-Hsieh BA. 2011. Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis. Infect Immun 79(11):4493-502. [PubMed: 21911464]  [MGI Ref ID J:177771]

Huang GJ; Smith AL; Gray DH; Cosgrove C; Singer BH; Edwards A; Sim S; Parent JM; Johnsen A; Mott R; Mathis D; Klenerman P; Benoist C; Flint J. 2010. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol 8(12):e1000561. [PubMed: 21179499]  [MGI Ref ID J:170591]

Huang W; Hu J; August A. 2013. Cutting Edge: Innate Memory CD8+ T Cells Are Distinct from Homeostatic Expanded CD8+ T Cells and Rapidly Respond to Primary Antigenic Stimuli. J Immunol 190(6):2490-4. [PubMed: 23408840]  [MGI Ref ID J:193676]

Iizuka K; Scalzo AA; Xian H; Yokoyama WM. 2008. Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes. J Immunol 180(5):3260-7. [PubMed: 18292550]  [MGI Ref ID J:131556]

Ismail N; Crossley EC; Stevenson HL; Walker DH. 2007. Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in ehrlichia-induced immunopathology in murine ehrlichiosis. Infect Immun 75(9):4608-20. [PubMed: 17562770]  [MGI Ref ID J:123934]

Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82. [PubMed: 12384415]  [MGI Ref ID J:163373]

Jarchum I; Baker JC; Yamada T; Takaki T; Marron MP; Serreze DV; DiLorenzo TP. 2007. In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice. Diabetes 56(10):2551-60. [PubMed: 17620420]  [MGI Ref ID J:126569]

Jarchum I; DiLorenzo TP. 2010. Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin. J Immunol 184(2):658-65. [PubMed: 19966211]  [MGI Ref ID J:159429]

Jay DC; Reed-Loisel LM; Jensen PE. 2008. Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells. J Immunol 180(5):2805-14. [PubMed: 18292501]  [MGI Ref ID J:131725]

Jin Y; Xia M; Saylor CM; Narayan K; Kang J; Wiest DL; Wang Y; Xiong N. 2010. Cutting edge: Intrinsic programming of thymic gammadeltaT cells for specific peripheral tissue localization. J Immunol 185(12):7156-60. [PubMed: 21068400]  [MGI Ref ID J:167476]

Joetham A; Takeda K; Miyahara N; Matsubara S; Ohnishi H; Koya T; Dakhama A; Gelfand EW. 2007. Activation of naturally occurring lung CD4+CD25+ regulatory T cells requires CD8 and MHC I interaction. Proc Natl Acad Sci U S A 104(38):15057-62. [PubMed: 17855564]  [MGI Ref ID J:125195]

Jordan MB; Hildeman D; Kappler J; Marrack P. 2004. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood 104(3):735-43. [PubMed: 15069016]  [MGI Ref ID J:92260]

Joyce S; Negishi I; Boesteanu A; DeSilva AD; Sharma P; Chorney MJ; Loh DY; Van Kaer L. 1996. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med 184(4):1579-84. [PubMed: 8879233]  [MGI Ref ID J:110770]

Junghans RP; Anderson CL. 1996. The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A 93(11):5512-6. [PubMed: 8643606]  [MGI Ref ID J:39252]

Kaba SA; McCoy ME; Doll TA; Brando C; Guo Q; Dasgupta D; Yang Y; Mittelholzer C; Spaccapelo R; Crisanti A; Burkhard P; Lanar DE. 2012. Protective antibody and CD8+ T-cell responses to the Plasmodium falciparum circumsporozoite protein induced by a nanoparticle vaccine. PLoS One 7(10):e48304. [PubMed: 23144750]  [MGI Ref ID J:192356]

Kamizono S; Duncan GS; Seidel MG; Morimoto A; Hamada K; Grosveld G; Akashi K; Lind EF; Haight JP; Ohashi PS; Look AT; Mak TW. 2009. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med 206(13):2977-86. [PubMed: 19995955]  [MGI Ref ID J:155677]

Kassiotis G; Bauer J; Akassoglou K; Lassmann H; Kollias G; Probert L. 1999. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. Eur J Immunol 29(3):912-7. [PubMed: 10092095]  [MGI Ref ID J:53471]

Kastenmuller W; Gasteiger G; Gronau JH; Baier R; Ljapoci R; Busch DH; Drexler I. 2007. Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J Exp Med 204(9):2187-98. [PubMed: 17709425]  [MGI Ref ID J:126086]

Kastenmuller W; Torabi-Parizi P; Subramanian N; Lammermann T; Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150(6):1235-48. [PubMed: 22980983]  [MGI Ref ID J:187962]

Katz J; Benoist C; Mathis D. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol 23(12):3358-60. [PubMed: 8258349]  [MGI Ref ID J:93557]

Kawabata H; Niwa A; Tsuji-Kawahara S; Uenishi H; Iwanami N; Matsukuma H; Abe H; Tabata N; Matsumura H; Miyazawa M. 2006. Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease. Int Immunol 18(1):183-98. [PubMed: 16352628]  [MGI Ref ID J:104156]

Keefe R; Dave V; Allman D; Wiest D; Kappes DJ. 1999. Regulation of lineage commitment distinct from positive selection. Science 286(5442):1149-53. [PubMed: 10550051]  [MGI Ref ID J:124533]

Kehren J; Desvignes C; Krasteva M; Ducluzeau MT; Assossou O; Horand F; Hahne M; Kagi D; Kaiserlian D; Nicolas JF. 1999. Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity. J Exp Med 189(5):779-86. [PubMed: 10049941]  [MGI Ref ID J:112018]

Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. [PubMed: 22056381]  [MGI Ref ID J:184027]

Kerksiek KM; Niedergang F; Chavrier P; Busch DH; Brocker T. 2005. Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. Blood 105(2):742-9. [PubMed: 15383465]  [MGI Ref ID J:96564]

Khan S; Bijker MS; Weterings JJ; Tanke HJ; Adema GJ; van Hall T; Drijfhout JW; Melief CJ; Overkleeft HS; van der Marel GA; Filippov DV; van der Burg SH; Ossendorp F. 2007. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem 282(29):21145-59. [PubMed: 17462991]  [MGI Ref ID J:124553]

Khare SD; Lee S; Bull MJ; Hanson J; Luthra HS; David CS. 2001. Spontaneous inflammatory disease in HLA-B27 transgenic mice does not require transporter of antigenic peptides. Clin Immunol 98(3):364-9. [PubMed: 11237560]  [MGI Ref ID J:115586]

Khare SD; Luthra HS; David CS. 1995. Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med 182(4):1153-8. [PubMed: 7561688]  [MGI Ref ID J:110767]

Kieper WC; Tan JT; Bondi-Boyd B; Gapin L; Sprent J; Ceredig R; Surh CD. 2002. Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. J Exp Med 195(12):1533-9. [PubMed: 12070281]  [MGI Ref ID J:132582]

Kim S; Li L; McMurtrey CP; Hildebrand WH; Weidanz JA; Gillanders WE; Diamond MS; Hansen TH. 2010. Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection. J Immunol 184(8):4423-30. [PubMed: 20212098]  [MGI Ref ID J:190226]

Kimura MY; Pobezinsky LA; Guinter TI; Thomas J; Adams A; Park JH; Tai X; Singer A. 2013. IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14(2):143-51. [PubMed: 23242416]  [MGI Ref ID J:192537]

Kimura T; Griffin DE. 2000. The role of CD8(+) T cells and major histocompatibility complex class I expression in the central nervous system of mice infected with neurovirulent Sindbis virus. J Virol 74(13):6117-25. [PubMed: 10846095]  [MGI Ref ID J:126435]

Kingsbury DJ; Mear JP; Witte DP; Taurog JD; Roopenian DC; Colbert RA. 2000. Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum 43(10):2290-6. [PubMed: 11037889]  [MGI Ref ID J:133830]

Kirby AC; Yrlid U; Svensson M; Wick MJ. 2001. Differential involvement of dendritic cell subsets during acute salmonella infection. J Immunol 166(11):6802-11. [PubMed: 11359839]  [MGI Ref ID J:69480]

Klezovich-Benard M; Corre JP; Jusforgues-Saklani H; Fiole D; Burjek N; Tournier JN; Goossens PL. 2012. Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins. PLoS Pathog 8(1):e1002481. [PubMed: 22253596]  [MGI Ref ID J:195407]

Kobayashi S; Yoshida K; Ward JM; Letterio JJ; Longenecker G; Yaswen L; Mittleman B; Mozes E; Roberts AB; Karlsson S; Kulkarni AB. 1999. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol 163(7):4013-9. [PubMed: 10491004]  [MGI Ref ID J:110828]

Kobrynski LJ; Sousa AO; Nahmias AJ; Lee FK. 2005. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol 174(4):1787-90. [PubMed: 15699104]  [MGI Ref ID J:96541]

Koh YI; Kim HY; Meyer EH; Pichavant M; Akbari O; Yasumi T; Savage PB; Dekruyff RH; Umetsu DT. 2008. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta2-microglobulin-deficient mice. J Immunol 181(7):4560-9. [PubMed: 18802058]  [MGI Ref ID J:141297]

Kohu K; Sato T; Ohno S; Hayashi K; Uchino R; Abe N; Nakazato M; Yoshida N; Kikuchi T; Iwakura Y; Inoue Y; Watanabe T; Habu S; Satake M. 2005. Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage. J Immunol 174(5):2627-36. [PubMed: 15728469]  [MGI Ref ID J:97715]

Koller BH; Marrack P; Kappler JW; Smithies O. 1990. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science 248(4960):1227-30. [PubMed: 2112266]  [MGI Ref ID J:64451]

Koller BH; Smithies O. 1989. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A 86(22):8932-5. [PubMed: 2682666]  [MGI Ref ID J:65612]

Koltun M; Nikolovski J; Strong K; Nikolic-Paterson D; Comper WD. 2005. Mechanism of hypoalbuminemia in rodents. Am J Physiol Heart Circ Physiol 288(4):H1604-10. [PubMed: 15539420]  [MGI Ref ID J:97362]

Konishi J; Iwabuchi K; Iwabuchi C; Ato M; Nagata JI; Onoe K; Nakagawa KI; Kasai M; Ogasawara K; Kawakami K; Onoe K. 2000. Thymic epithelial cells responsible for impaired generation of NK-T thymocytes in Alymphoplasia mutant mice. Cell Immunol 206(1):26-35. [PubMed: 11161435]  [MGI Ref ID J:67083]

Kostek CA; Dominov JA; Miller JB. 2002. Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. Am J Pathol 160(3):833-9. [PubMed: 11891182]  [MGI Ref ID J:75304]

Koyama M; Hashimoto D; Aoyama K; Matsuoka K; Karube K; Niiro H; Harada M; Tanimoto M; Akashi K; Teshima T. 2009. Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood 113(9):2088-95. [PubMed: 19144988]  [MGI Ref ID J:146164]

Krawczyk C; Oliveira-dos-Santos A; Sasaki T; Griffiths E; Ohashi PS; Snapper S; Alt F; Penninger JM. 2002. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16(3):331-43. [PubMed: 11911819]  [MGI Ref ID J:111206]

Kunisaki Y; Tanaka Y; Sanui T; Inayoshi A; Noda M; Nakayama T; Harada M; Taniguchi M; Sasazuki T; Fukui Y. 2006. DOCK2 is required in T cell precursors for development of Valpha14 NK T cells. J Immunol 176(8):4640-5. [PubMed: 16585555]  [MGI Ref ID J:131163]

Lacorazza HD; Nikolich-Zugich J. 2004. Exclusion and inclusion of TCR alpha proteins during T cell development in TCR-transgenic and normal mice. J Immunol 173(9):5591-600. [PubMed: 15494509]  [MGI Ref ID J:132808]

Lamouse-Smith E; McCarthy SA. 1997. Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype. Cell Immunol 179(2):107-15. [PubMed: 9268494]  [MGI Ref ID J:42696]

Larena M; Prow NA; Hall RA; Petrovsky N; Lobigs M. 2013. JE-ADVAX vaccine protection against Japanese encephalitis virus mediated by memory B cells in the absence of CD8(+) T cells and pre-exposure neutralizing antibody. J Virol 87(8):4395-402. [PubMed: 23388724]  [MGI Ref ID J:197217]

Lau LL; Spain LM. 2000. Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice. Mech Ageing Dev 114(2):101-21. [PubMed: 10799708]  [MGI Ref ID J:111547]

Lavi E; Das Sarma J; Weiss SR. 1999. Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice. Pathobiology 67(2):75-83. [PubMed: 10023135]  [MGI Ref ID J:54035]

Lawson VJ; Maurice D; Silk JD; Cerundolo V; Weston K. 2009. Aberrant selection and function of invariant NKT cells in the absence of AP-1 transcription factor Fra-2. J Immunol 183(4):2575-84. [PubMed: 19620306]  [MGI Ref ID J:151549]

Lee BO; Jones JE; Peters CJ; Whitacre D; Frelin L; Hughes J; Kim WK; Milich DR. 2011. Identification of a unique double-negative regulatory T-cell population. Immunology 134(4):434-47. [PubMed: 22044159]  [MGI Ref ID J:178639]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee JW; Epardaud M; Sun J; Becker JE; Cheng AC; Yonekura AR; Heath JK; Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8(2):181-90. [PubMed: 17195844]  [MGI Ref ID J:117862]

Leite-de-Moraes MC; Herbelin A; Gombert JM; Vicari A; Papiernik M ; Dy M. 1997. Requirement of IL-7 for IL-4-producing potential of MHC class I-selected CD4-CD8-TCR alpha beta+ thymocytes. Int Immunol 9(1):73-9. [PubMed: 9043949]  [MGI Ref ID J:40708]

Levy JE; Montross LK; Andrews NC. 2000. Genes that modify the hemochromatosis phenotype in mice [see comments] J Clin Invest 105(9):1209-16. [PubMed: 10791995]  [MGI Ref ID J:62112]

Li L; Sullivan BA; Aldrich CJ; Soloski MJ; Forman J; Grandea AG 3rd; Jensen PE; Van Kaer L. 2004. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol 173(6):3707-15. [PubMed: 15356116]  [MGI Ref ID J:92768]

Li LP; Lampert JC; Chen X; Leitao C; Popovic J; Muller W; Blankenstein T. 2010. Transgenic mice with a diverse human T cell antigen receptor repertoire. Nat Med 16(9):1029-34. [PubMed: 20693993]  [MGI Ref ID J:164445]

Li W; Murthy AK; Guentzel MN; Seshu J; Forsthuber TG; Zhong G; Arulanandam BP. 2008. Antigen-Specific CD4+ T Cells Produce Sufficient IFN-{gamma} to Mediate Robust Protective Immunity against Genital Chlamydia muridarum Infection. J Immunol 180(5):3375-82. [PubMed: 18292563]  [MGI Ref ID J:131578]

Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. [PubMed: 18515407]  [MGI Ref ID J:138638]

Lin JS; Yang CW; Wang DW; Wu-Hsieh BA. 2005. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J Immunol 174(10):6282-91. [PubMed: 15879127]  [MGI Ref ID J:109987]

Linette GP; Grusby MJ; Hedrick SM; Hansen TH; Glimcher LH; Korsmeyer SJ. 1994. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1(3):197-205. [PubMed: 7889408]  [MGI Ref ID J:81144]

Liu T; Chambers B; Diehl AD; Van Kaer L; Jondal M; Ljunggren HG. 1997. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells. J Immunol 159(11):5364-71. [PubMed: 9548476]  [MGI Ref ID J:110663]

Ljunggren HG; Van Kaer L; Ashton-Rickardt PG; Tonegawa S; Ploegh HL. 1995. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur J Immunol 25(1):174-8. [PubMed: 7843229]  [MGI Ref ID J:22500]

Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL. 1995. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol 7(6):975-84. [PubMed: 7577806]  [MGI Ref ID J:26520]

Loconto J; Papes F; Chang E; Stowers L; Jones EP; Takada T; Kumanovics A; Lindahl KF; Dulac C. 2003. Functional Expression of Murine V2R Pheromone Receptors Involves Selective Association with the M10 and M1 Families of MHC Class Ib Molecules. Cell 112(5):607-18. [PubMed: 12628182]  [MGI Ref ID J:82444]

Logunova NN; Viret C; Pobezinsky LA; Miller SA; Kazansky DB; Sundberg JP; Chervonsky AV. 2005. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med 202(1):73-84. [PubMed: 15998789]  [MGI Ref ID J:100625]

Loirat D; Mancini-Bourgine M; Abastado JP; Michel ML. 2003. HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection. Int Immunol 15(10):1125-36. [PubMed: 13679383]  [MGI Ref ID J:85801]

Lowin-Kropf B; Kunz B; Beermann F; Held W. 2000. Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1. J Immunol 165(3):1314-21. [PubMed: 10903732]  [MGI Ref ID J:120439]

Lowin-Kropf B; Kunz B; Schneider P; Held W. 2002. A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 32(3):773-82. [PubMed: 11870621]  [MGI Ref ID J:108602]

Ma G; Pan PY; Eisenstein S; Divino CM; Lowell CA; Takai T; Chen SH. 2011. Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells. Immunity 34(3):385-95. [PubMed: 21376641]  [MGI Ref ID J:170325]

Maeda M; Shadeo A; MacFadyen AM; Takei F. 2004. CD1d-independent NKT cells in beta 2-microglobulin-deficient mice have hybrid phenotype and function of NK and T cells. J Immunol 172(10):6115-22. [PubMed: 15128797]  [MGI Ref ID J:132824]

Maldonado MA; Eisenberg RA; Roper E; Cohen PL; Kotzin BL. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 181(2):641-8. [PubMed: 7530760]  [MGI Ref ID J:22506]

Maldonado MA; MacDonald GC; Kakkanaiah VN; Fecho K; Dransfield M; Sekiguchi D; Cohen PL; Eisenberg RA. 1999. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo. J Immunol 163(6):3138-42. [PubMed: 10477580]  [MGI Ref ID J:119603]

Marguerat S; MacDonald HR; Kraehenbuhl JP; van Meerwijk JP. 1999. Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin. J Immunol 163(7):4033-40. [PubMed: 10491007]  [MGI Ref ID J:119199]

Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980]  [MGI Ref ID J:109851]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Martin B; Becourt C; Bienvenu B; Lucas B. 2006. Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood 108(1):270-7. [PubMed: 16527889]  [MGI Ref ID J:135378]

Martin B; Bourgeois C; Dautigny N; Lucas B. 2003. On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proc Natl Acad Sci U S A 100(10):6021-6. [PubMed: 12719530]  [MGI Ref ID J:126900]

Masuda A; Nakamura A; Maeda T; Sakamoto Y; Takai T. 2007. Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation. J Exp Med 204(4):907-20. [PubMed: 17420263]  [MGI Ref ID J:125576]

Matte CC; Liu J; Cormier J; Anderson BE; Athanasiadis I; Jain D; McNiff J; Shlomchik WD. 2004. Donor APCs are required for maximal GVHD but not for GVL. Nat Med 10(9):987-92. [PubMed: 15286785]  [MGI Ref ID J:92850]

Matte-Martone C; Liu J; Jain D; McNiff J; Shlomchik WD. 2008. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 111(7):3884-92. [PubMed: 18223170]  [MGI Ref ID J:133502]

Maurice D; Hooper J; Lang G; Weston K. 2007. c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3. EMBO J 26(15):3629-40. [PubMed: 17641686]  [MGI Ref ID J:124106]

Maurice MM; Gould DS; Carroll J; Vugmeyster Y; Ploegh HL. 2001. Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc Natl Acad Sci U S A 98(13):7437-42. [PubMed: 11404484]  [MGI Ref ID J:70614]

McCaughtry TM; Etzensperger R; Alag A; Tai X; Kurtulus S; Park JH; Grinberg A; Love P; Feigenbaum L; Erman B; Singer A. 2012. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209(12):2263-76. [PubMed: 23109710]  [MGI Ref ID J:190889]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Meissner NN; Lund FE; Han S; Harmsen A. 2005. CD8 T cell-mediated lung damage in response to the extracellular pathogen pneumocystis is dependent on MHC class I expression by radiation-resistant lung cells. J Immunol 175(12):8271-9. [PubMed: 16339567]  [MGI Ref ID J:122256]

Mendiratta SK; Kovalik JP; Hong S; Singh N; Martin WD; Van Kaer L. 1999. Peptide dependency of alloreactive CD4+ T cell responses. Int Immunol 11(3):351-60. [PubMed: 10221647]  [MGI Ref ID J:110542]

Mezo AR; McDonnell KA; Hehir CA; Low SC; Palombella VJ; Stattel JM; Kamphaus GD; Fraley C; Zhang Y; Dumont JA; Bitonti AJ. 2008. Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn. Proc Natl Acad Sci U S A 105(7):2337-42. [PubMed: 18272495]  [MGI Ref ID J:132181]

Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383]  [MGI Ref ID J:87075]

Mitchell AJ; Hansen AM; Hee L; Ball HJ; Potter SM; Walker JC; Hunt NH. 2005. Early cytokine production is associated with protection from murine cerebral malaria. Infect Immun 73(9):5645-53. [PubMed: 16113282]  [MGI Ref ID J:100415]

Mohammed JP; Fusakio ME; Rainbow DB; Moule C; Fraser HI; Clark J; Todd JA; Peterson LB; Savage PB; Wills-Karp M; Ridgway WM; Wicker LS; Mattner J. 2011. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. J Immunol 187(1):337-49. [PubMed: 21613619]  [MGI Ref ID J:175942]

Moos T; Trinder D; Morgan EH. 2002. Effect of iron status on DMT1 expression in duodenal enterocytes from beta2-microglobulin knockout mice. Am J Physiol Gastrointest Liver Physiol 283(3):G687-94. [PubMed: 12181184]  [MGI Ref ID J:78896]

Moro H; Otero DC; Tanabe Y; David M. 2011. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One 6(9):e24972. [PubMed: 21949815]  [MGI Ref ID J:177873]

Morris SC; Coffman RL; Finkelman FD. 1998. In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells. J Immunol 160(7):3299-304. [PubMed: 9531287]  [MGI Ref ID J:111652]

Mukherjee R; Zhang Z; Zhong R; Yin ZQ; Roopenian DC; Jevnikar AM. 1996. Lupus nephritis in the absence of renal major histocompatibility complex class I and class II molecules. J Am Soc Nephrol 7(11):2445-52. [PubMed: 8959638]  [MGI Ref ID J:39693]

Muller D; Koller BH; Whitton JL; LaPan KE; Brigman KK; Frelinger JA. 1992. LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science 255(5051):1576-8. [PubMed: 1347959]  [MGI Ref ID J:2765]

Muller D; Pakpreo P; Filla J; Pederson K; Cigel F; Malkovska V. 1995. Increased gamma-delta T-lymphocyte response to Mycobacterium bovis BCG in major histocompatibility complex class I-deficient mice. Infect Immun 63(6):2361-6. [PubMed: 7768622]  [MGI Ref ID J:111338]

Muller JR; Waldmann TA; Dubois S. 2012. Selective Dependence of H2-M3-Restricted CD8 Responses on IL-15. J Immunol 188(6):2575-82. [PubMed: 22312130]  [MGI Ref ID J:181860]

Murakami M; Paul WE. 1998. Age-dependent appearance of NK1.1+ T cells in the livers of beta2-microglobulin knockout and SJL mice. J Immunol 160(6):2649-54. [PubMed: 9510163]  [MGI Ref ID J:46188]

Murali-Krishna K; Ahmed R. 2000. Cutting edge: naive T cells masquerading as memory cells. J Immunol 165(4):1733-7. [PubMed: 10925249]  [MGI Ref ID J:120420]

Murali-Krishna K; Lau LL; Sambhara S; Lemonnier F; Altman J; Ahmed R. 1999. Persistence of memory CD8 T cells in MHC class I-deficient mice [see comments] Science 286(5443):1377-81. [PubMed: 10558996]  [MGI Ref ID J:58469]

Muroi S; Naoe Y; Miyamoto C; Akiyama K; Ikawa T; Masuda K; Kawamoto H; Taniuchi I. 2008. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nat Immunol 9(10):1113-21. [PubMed: 18776907]  [MGI Ref ID J:141142]

Muroi S; Tanaka H; Miyamoto C; Taniuchi I. 2013. Cutting edge: fine-tuning of thpok gene activation by an enhancer in close proximity to its own silencer. J Immunol 190(4):1397-401. [PubMed: 23315079]  [MGI Ref ID J:193321]

Nagarajan NA; Gonzalez F; Shastri N. 2012. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol 13(6):579-86. [PubMed: 22522492]  [MGI Ref ID J:186455]

Nakajima S; Hida S; Taki S. 2008. IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. Biochem Biophys Res Commun 369(4):1139-43. [PubMed: 18339305]  [MGI Ref ID J:134069]

Nasreen M; Ueno T; Saito F; Takahama Y. 2003. In vivo treatment of class II MHC-deficient mice with anti-TCR antibody restores the generation of circulating CD4 T cells and optimal architecture of thymic medulla. J Immunol 171(7):3394-400. [PubMed: 14500633]  [MGI Ref ID J:120396]

Niens M; Grier AE; Marron M; Kay TW; Greiner DL; Serreze DV. 2011. Prevention of 'Humanized' diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes 60(4):1229-36. [PubMed: 21346176]  [MGI Ref ID J:171756]

Nitta T; Murata S; Sasaki K; Fujii H; Ripen AM; Ishimaru N; Koyasu S; Tanaka K; Takahama Y. 2010. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity 32(1):29-40. [PubMed: 20045355]  [MGI Ref ID J:157648]

Nitta T; Nitta S; Lei Y; Lipp M; Takahama Y. 2009. CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci U S A 106(40):17129-33. [PubMed: 19805112]  [MGI Ref ID J:153692]

Noble A; Pestano GA; Cantor H. 1998. Suppression of immune responses by CD8 cells. I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells. J Immunol 160(2):559-65. [PubMed: 9551888]  [MGI Ref ID J:45187]

Noble A; Zhao ZS; Cantor H. 1998. Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. J Immunol 160(2):566-71. [PubMed: 9551889]  [MGI Ref ID J:45188]

Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434]  [MGI Ref ID J:115484]

Ochi A; Nguyen AH; Bedrosian AS; Mushlin HM; Zarbakhsh S; Barilla R; Zambirinis CP; Fallon NC; Rehman A; Pylayeva-Gupta Y; Badar S; Hajdu CH; Frey AB; Bar-Sagi D; Miller G. 2012. MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671-87. [PubMed: 22908323]  [MGI Ref ID J:191814]

Ohmura K; Ishimori N; Ohmura Y; Tokuhara S; Nozawa A; Horii S; Andoh Y; Fujii S; Iwabuchi K; Onoe K; Tsutsui H. 2010. Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice. Arterioscler Thromb Vasc Biol 30(2):193-9. [PubMed: 19910631]  [MGI Ref ID J:172110]

Okamoto N; Kanie O; Huang YY; Fujii R; Watanabe H; Shimamura M. 2005. Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain. Chem Biol 12(6):677-83. [PubMed: 15975513]  [MGI Ref ID J:140924]

Oliveira AL; Thams S; Lidman O; Piehl F; Hokfelt T; Karre K; Linda H; Cullheim S. 2004. A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy. Proc Natl Acad Sci U S A 101(51):17843-8. [PubMed: 15591351]  [MGI Ref ID J:95276]

Oliveira GA; Kumar KA; Calvo-Calle JM; Othoro C; Altszuler D; Nussenzweig V; Nardin EH. 2008. Class II-restricted protective immunity induced by malaria sporozoites. Infect Immun 76(3):1200-6. [PubMed: 18160479]  [MGI Ref ID J:131605]

Oppenheim DE; Roberts SJ; Clarke SL; Filler R; Lewis JM; Tigelaar RE; Girardi M; Hayday AC. 2005. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nat Immunol 6(9):928-37. [PubMed: 16116470]  [MGI Ref ID J:100454]

Ortega SB; Kashi VP; Tyler AF; Cunnusamy K; Mendoza JP; Karandikar NJ. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J Immunol 191(1):117-26. [PubMed: 23733879]  [MGI Ref ID J:205352]

Osorio RW; Ascher NL; Melzer JS; Stock PG. 1994. beta-2 Microglobulin gene disruption prolongs murine islet allograft survival in NOD mice. Transplant Proc 26(2):752. [PubMed: 8171644]  [MGI Ref ID J:17881]

Pascolo S; Bervas N; Ure JM; Smith AG; Lemonnier FA; Perarnau B. 1997. HLA-A2.1-restricted education and cytolytic activity of CD8(+) T lymphocytes from beta2 microglobulin (beta2m) HLA-A2.1 monochain transgenic H-2Db beta2m double knockout mice. J Exp Med 185(12):2043-51. [PubMed: 9182675]  [MGI Ref ID J:41077]

Patel R; Belanger S; Tai LH; Troke AD; Makrigiannis AP. 2010. Effect of Ly49 haplotype variance on NK cell function and education. J Immunol 185(8):4783-92. [PubMed: 20855875]  [MGI Ref ID J:164728]

Paterson RK; Burkly LC; Kurahara DK; Dunlap A; Flavell RA; Finkel TH. 1994. Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage. J Immunol 153(8):3491-503. [PubMed: 7930572]  [MGI Ref ID J:131345]

Peng Y; Shao H; Ke Y; Zhang P; Xiang J; Kaplan HJ; Sun D. 2006. In vitro activation of CD8 interphotoreceptor retinoid-binding protein-specific T cells requires not only antigenic stimulation but also exogenous growth factors. J Immunol 176(8):5006-14. [PubMed: 16585597]  [MGI Ref ID J:131181]

Peshes-Yaloz N; Rosen D; Sondel PM; Krammer PH; Berke G. 2007. Up-regulation of Fas (CD95) expression in tumour cells in vivo. Immunology 120(4):502-11. [PubMed: 17343612]  [MGI Ref ID J:122702]

Pobezinsky LA; Angelov GS; Tai X; Jeurling S; Van Laethem F; Feigenbaum L; Park JH; Singer A. 2012. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 13(6):569-78. [PubMed: 22544394]  [MGI Ref ID J:186451]

Popovic J; Li LP; Kloetzel PM; Leisegang M; Uckert W; Blankenstein T. 2011. The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed. Blood 118(4):946-54. [PubMed: 21613253]  [MGI Ref ID J:174872]

Prajeeth CK; Haeberlein S; Sebald H; Schleicher U; Bogdan C. 2011. Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity. Infect Immun 79(7):2699-708. [PubMed: 21518784]  [MGI Ref ID J:173486]

Qi CF; Zhou JX; Lee CH; Naghashfar Z; Xiang S; Kovalchuk AL; Fredrickson TN; Hartley JW; Roopenian DC; Davidson WF; Janz S; Morse HC 3rd. 2007. Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer Res 67(6):2439-47. [PubMed: 17363561]  [MGI Ref ID J:120309]

Qian S; Fu F; Li Y; Gao L; Lu L; Noyola H; Rao AS; Thomson AW; Fung JJ. 1995. Presensitization by skin grafting from major histocompatibility complex class I or major histocompatibility complex class II deficient mice identifies class I antigens as inducers of allosensitization. Immunology 85(1):82-7. [PubMed: 7635525]  [MGI Ref ID J:25162]

Rafei M; Hardy MP; Williams P; Vanegas JR; Forner KA; Dulude G; Labrecque N; Galipeau J; Perreault C. 2011. Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes. J Immunol 187(6):3133-44. [PubMed: 21844388]  [MGI Ref ID J:179243]

Rafei M; Rouette A; Brochu S; Vanegas JR; Perreault C. 2013. Differential effects of gammac cytokines on postselection differentiation of CD8 thymocytes. Blood 121(1):107-17. [PubMed: 23043071]  [MGI Ref ID J:192369]

Ranson T; Vosshenrich CA; Corcuff E; Richard O; Laloux V; Lehuen A; Di Santo JP. 2003. IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc Natl Acad Sci U S A 100(5):2663-8. [PubMed: 12598649]  [MGI Ref ID J:91423]

Ranson T; Vosshenrich CA; Corcuff E; Richard O; Muller W; Di Santo JP. 2003. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 101(12):4887-93. [PubMed: 12586624]  [MGI Ref ID J:132257]

Rifa'i M; Shi Z; Zhang SY; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells. Int Immunol 20(7):937-47. [PubMed: 18495626]  [MGI Ref ID J:137065]

Riol-Blanco L; Lazarevic V; Awasthi A; Mitsdoerffer M; Wilson BS; Croxford A; Waisman A; Kuchroo VK; Glimcher LH; Oukka M. 2010. IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections. J Immunol 184(4):1710-20. [PubMed: 20083652]  [MGI Ref ID J:159487]

Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. J Immunol 191(6):2865-9. [PubMed: 23960238]  [MGI Ref ID J:205867]

Robertson NJ; Chai JG; Millrain M; Scott D; Hashim F; Manktelow E; Lemonnier F; Simpson E; Dyson J. 2007. Natural regulation of immunity to minor histocompatibility antigens. J Immunol 178(6):3558-65. [PubMed: 17339452]  [MGI Ref ID J:151739]

Rock F; Hadeler KP; Rammensee HG; Overath P. 2007. Quantitative analysis of mouse urine volatiles: in search of MHC-dependent differences. PLoS ONE 2(5):e429. [PubMed: 17487279]  [MGI Ref ID J:129348]

Rolph MS; Raupach B; Kobernick HH; Collins HL; Perarnau B; Lemonnier FA; Kaufmann SH. 2001. MHC class Ia-restricted T cells partially account for beta2-microglobulin-dependent resistance to Mycobacterium tuberculosis. Eur J Immunol 31(6):1944-9. [PubMed: 11433392]  [MGI Ref ID J:80887]

Rothenberg BE; Voland JR. 1996. beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc Natl Acad Sci U S A 93(4):1529-34. [PubMed: 8643666]  [MGI Ref ID J:31732]

Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H. 1999. Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice. J Immunol 162(5):2829-36. [PubMed: 10072530]  [MGI Ref ID J:124536]

Ru Z; Xiao W; Pajot A; Kou Z; Sun S; Maillere B; Zhao G; Ojcius DM; Lone YC; Zhou Y. 2012. Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein. PLoS One 7(3):e32247. [PubMed: 22403638]  [MGI Ref ID J:186853]

Sakai Y; Tanaka Y; Yanagihara T; Watanabe M; Duan X; Terasawa M; Nishikimi A; Sanematsu F; Fukui Y. 2013. The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation. Blood 122(3):386-93. [PubMed: 23719299]  [MGI Ref ID J:201343]

Salcedo M; Andersson M; Lemieux S; Van Kaer L; Chambers BJ; Ljunggren HG. 1998. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur J Immunol 28(4):1315-21. [PubMed: 9565371]  [MGI Ref ID J:114261]

Salcedo M; Diehl AD; Olsson-Alheim MY; Sundback J; Van Kaer L ; Karre K ; Ljunggren HG. 1997. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J Immunol 158(7):3174-80. [PubMed: 9120271]  [MGI Ref ID J:39441]

Sanapala S; Yu JJ; Murthy AK; Li W; Guentzel MN; Chambers JP; Klose KE; Arulanandam BP. 2012. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida DeltafopC vaccine strain. Infect Immun 80(6):2177-85. [PubMed: 22493083]  [MGI Ref ID J:186522]

Santos MM; de Sousa M; Rademakers LH; Clevers H; Marx JJ; Schilham MW. 2000. Iron overload and heart fibrosis in mice deficient for both ss2-microglobulin and rag1 Am J Pathol 157(6):1883-92. [PubMed: 11106561]  [MGI Ref ID J:66131]

Sarafova SD; Erman B; Yu Q; Van Laethem F; Guinter T; Sharrow SO; Feigenbaum L; Wildt KF; Ellmeier W; Singer A. 2005. Modulation of coreceptor transcription during positive selection dictates lineage fate independently of TCR/coreceptor specificity. Immunity 23(1):75-87. [PubMed: 16039581]  [MGI Ref ID J:100541]

Sarafova SD; Van Laethem F; Adoro S; Guinter T; Sharrow SO; Feigenbaum L; Singer A. 2009. Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. Immunity 31(3):480-90. [PubMed: 19747858]  [MGI Ref ID J:152836]

Sasada T; Yang Y; Lai CC; Touma M; Clayton LK; Liu JH; Parisini E; Wang JH; Reinherz EL. 2003. Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation. Eur J Immunol 33(2):368-80. [PubMed: 12645934]  [MGI Ref ID J:115696]

Sauder C; Hallensleben W; Pagenstecher A; Schneckenburger S; Biro L; Pertlik D; Hausmann J; Suter M; Staeheli P. 2000. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74(19):9267-80. [PubMed: 10982374]  [MGI Ref ID J:64497]

Schaible UE; Collins HL; Priem F; Kaufmann SH. 2002. Correction of the Iron Overload Defect in beta-2-Microglobulin Knockout Mice by Lactoferrin Abolishes Their Increased Susceptibility to Tuberculosis. J Exp Med 196(11):1507-13. [PubMed: 12461085]  [MGI Ref ID J:80527]

Schmedt C; Tarakhovsky A. 2001. Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk). J Exp Med 193(7):815-26. [PubMed: 11283154]  [MGI Ref ID J:120548]

Schmidt D; Verdaguer J; Averill N; Santamaria P. 1997. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med 186(7):1059-75. [PubMed: 9314555]  [MGI Ref ID J:108768]

Scotto M; Afonso G; Larger E; Raverdy C; Lemonnier FA; Carel JC; Dubois-Laforgue D; Baz B; Levy D; Gautier JF; Launay O; Bruno G; Boitard C; Sechi LA; Hutton JC; Davidson HW; Mallone R. 2012. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia 55(7):2026-31. [PubMed: 22526607]  [MGI Ref ID J:188655]

Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124]  [MGI Ref ID J:118778]

Serreze DV; Leiter EH; Christianson GJ; Greiner D; Roopenian DC. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43(3):505-9. [PubMed: 8314025]  [MGI Ref ID J:17000]

Serreze DV; Marron MP; Dilorenzo TP. 2007. 'Humanized' HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes. Ann N Y Acad Sci 1103:103-11. [PubMed: 17376821]  [MGI Ref ID J:123948]

Seymour BW; Gershwin LJ; Coffman RL. 1998. Aerosol-induced immunoglobulin (Ig)-E unresponsiveness to ovalbumin does not require CD8+ or T cell receptor (TCR)-gamma/delta+ T cells or interferon (IFN)-gamma in a murine model of allergen sensitization. J Exp Med 187(5):721-31. [PubMed: 9480982]  [MGI Ref ID J:46078]

Shah SA; Simpson SJ; Brown LF; Comiskey M; de Jong YP; Allen D; Terhorst C. 1998. Development of colonic adenocarcinomas in a mouse model of ulcerative colitis. Inflamm Bowel Dis 4(3):196-202. [PubMed: 9741021]  [MGI Ref ID J:51450]

Sherwood ER; Enoh VT; Murphey ED; Lin CY. 2004. Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture. Lab Invest 84(12):1655-65. [PubMed: 15448711]  [MGI Ref ID J:110788]

Sherwood ER; Lin CY; Tao W; Hartmann CA; Dujon JE; French AJ; Varma TK. 2003. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. Am J Respir Crit Care Med 167(12):1641-9. [PubMed: 12626348]  [MGI Ref ID J:103038]

Shi Z; Rifa'i M; Lee YH; Shiku H; Isobe K; Suzuki H. 2008. Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Immunology 124(1):121-8. [PubMed: 18205792]  [MGI Ref ID J:136528]

Shimamura M; Huang YY. 2002. Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain. FEBS Lett 516(1-3):97-100. [PubMed: 11959111]  [MGI Ref ID J:109181]

Shimamura M; Huang YY; Kobayashi M; Goji H. 2009. Altered production of immunoregulatory cytokines by invariant Valpha19 TCR-bearing cells dependent on the duration and intensity of TCR engagement. Int Immunol 21(2):179-85. [PubMed: 19106232]  [MGI Ref ID J:144520]

Shimamura M; Huang YY; Okamoto N; Suzuki N; Yasuoka J; Morita K; Nishiyama A; Amano Y; Mishina T. 2007. Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines. Eur J Immunol 37(7):1836-44. [PubMed: 17559170]  [MGI Ref ID J:146398]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Simpson SJ; Mizoguchi E; Allen D; Bhan AK; Terhorst C. 1995. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol 25(9):2618-25. [PubMed: 7589135]  [MGI Ref ID J:39981]

Singer DS; Zinger H; Kohn LD; Mozes E. 1999. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol 29(7):2259-68. [PubMed: 10427989]  [MGI Ref ID J:115300]

Smith AL; Hayday AC. 2000. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun 68(11):6273-80. [PubMed: 11035735]  [MGI Ref ID J:133107]

Smyth MJ; Snook MB. 1999. Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice. Cell Immunol 196(1):51-9. [PubMed: 10486155]  [MGI Ref ID J:57956]

Sohn KJ; Shah SA; Reid S; Choi M; Carrier J; Comiskey M; Terhorst C; Kim YI. 2001. Molecular Genetics of Ulcerative Colitis-associated Colon Cancer in the Interleukin 2- and beta(2)-Microglobulin-deficient Mouse. Cancer Res 61(18):6912-7. [PubMed: 11559569]  [MGI Ref ID J:71656]

Solaymani-Mohammadi S; Singer SM. 2011. Host immunity and pathogen strain contribute to intestinal disaccharidase impairment following gut infection. J Immunol 187(7):3769-75. [PubMed: 21873528]  [MGI Ref ID J:179334]

Somigliana E; Vigano P; Filardo P; Candiani M; Vignali M; Panina-Bordignon P. 2001. Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking beta(2)-microglobulin and interleukin-12p40. Fertil Steril 75(1):203-6. [PubMed: 11163839]  [MGI Ref ID J:66996]

Spencer CT; Dragovic SM; Conant SB; Gray JJ; Zheng M; Samir P; Niu X; Moutaftsi M; Van Kaer L; Sette A; Link AJ; Joyce S. 2013. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol 43(5):1162-72. [PubMed: 23386199]  [MGI Ref ID J:198053]

Spriggs MK; Koller BH; Sato T; Morrissey PJ; Fanslow WC; Smithies O; Voice RF; Widmer MB; Maliszewski CR. 1992. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci U S A 89(13):6070-4. [PubMed: 1631092]  [MGI Ref ID J:111183]

Sproule TJ; Jazwinska EC; Britton RS; Bacon BR; Fleming RE; Sly WS; Roopenian DC. 2001. Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice. Proc Natl Acad Sci U S A 98(9):5170-4. [PubMed: 11309500]  [MGI Ref ID J:68985]

Street SE; Hayakawa Y; Zhan Y; Lew AM; MacGregor D; Jamieson AM; Diefenbach A; Yagita H; Godfrey DI; Smyth MJ. 2004. Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and {gamma}{delta} T Cells. J Exp Med 199(6):879-884. [PubMed: 15007091]  [MGI Ref ID J:90480]

Su HC; Cousens LP; Fast LD; Slifka MK; Bungiro RD; Ahmed R; Biron CA. 1998. CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2. J Immunol 160(10):5007-17. [PubMed: 9590250]  [MGI Ref ID J:111005]

Su HC; Orange JS; Fast LD; Chan AT; Simpson SJ; Terhorst C; Biron CA. 1994. IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice. J Immunol 153(12):5674-81. [PubMed: 7989765]  [MGI Ref ID J:21901]

Sullivan BA; Kraj P; Weber DA; Ignatowicz L; Jensen PE. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17(1):95-105. [PubMed: 12150895]  [MGI Ref ID J:132383]

Sun JC; Lanier LL. 2008. Cutting edge: viral infection breaks NK cell tolerance to 'missing self'. J Immunol 181(11):7453-7. [PubMed: 19017932]  [MGI Ref ID J:142209]

Sun K; Alvarez M; Ames E; Barao I; Chen M; Longo DL; Redelman D; Murphy WJ. 2012. Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood 119(6):1590-8. [PubMed: 22184406]  [MGI Ref ID J:181726]

Suzuki H; Punt JA; Granger LG; Singer A. 1995. Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2(4):413-25. [PubMed: 7719943]  [MGI Ref ID J:189417]

Takaki T; Marron MP; Mathews CE; Guttmann ST; Bottino R; Trucco M; DiLorenzo TP; Serreze DV. 2006. HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol 176(5):3257-65. [PubMed: 16493087]  [MGI Ref ID J:121685]

Takeda K; Nakayama M; Sakaki M; Hayakawa Y; Imawari M; Ogasawara K; Okumura K; Smyth MJ. 2011. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90(4):777-85. [PubMed: 21712396]  [MGI Ref ID J:177544]

Taki S; Nakajima S; Ichikawa E; Saito T; Hida S. 2005. IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells. J Immunol 174(10):6005-12. [PubMed: 15879093]  [MGI Ref ID J:98991]

Tan JT; Dudl E; LeRoy E; Murray R; Sprent J; Weinberg KI; Surh CD. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98(15):8732-7. [PubMed: 11447288]  [MGI Ref ID J:93058]

Tanaka H; Naito T; Muroi S; Seo W; Chihara R; Miyamoto C; Kominami R; Taniuchi I. 2013. Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus. EMBO J 32(8):1183-94. [PubMed: 23481257]  [MGI Ref ID J:195348]

Taniguchi RT; Guzior D; Kumar V. 2007. 2B4 inhibits NK-cell fratricide. Blood 110(6):2020-3. [PubMed: 17537992]  [MGI Ref ID J:146407]

Tao W; Sherwood ER. 2004. Beta2-microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis. Am J Physiol Regul Integr Comp Physiol 286(3):R569-75. [PubMed: 14630624]  [MGI Ref ID J:95749]

Tarakanova VL; Kreisel F; White DW; Virgin HW 4th. 2008. Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. J Virol 82(2):1034-9. [PubMed: 17977975]  [MGI Ref ID J:130353]

Tarakanova VL; Suarez F; Tibbetts SA; Jacoby MA; Weck KE; Hess JL; Speck SH; Virgin HW 4th. 2005. Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol 79(23):14668-79. [PubMed: 16282467]  [MGI Ref ID J:102883]

Tay CH; Welsh RM; Brutkiewicz RR. 1995. NK cell response to viral infections in beta 2-microglobulin-deficient mice. J Immunol 154(2):780-9. [PubMed: 7529286]  [MGI Ref ID J:22235]

Taylor SF; Cottey RJ; Zander DS; Bender BS. 1997. Influenza infection of beta 2-microglobulin-deficient (beta 2m-/-) mice reveals a loss of CD4+ T cell functions with aging. J Immunol 159(7):3453-9. [PubMed: 9317144]  [MGI Ref ID J:110680]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Teh SJ; Killeen N; Tarakhovsky A; Littman DR; Teh HS. 1997. CD2 regulates the positive selection and function of antigen-specific CD4- CD8+ T cells. Blood 89(4):1308-18. [PubMed: 9028954]  [MGI Ref ID J:111606]

Terabe M; Tagaya Y; Zhu Q; Granger L; Roederer M; Waldmann TA; Berzofsky JA. 2008. IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells. J Immunol 180(11):7276-86. [PubMed: 18490727]  [MGI Ref ID J:136310]

Terra R; Labrecque N; Perreault C. 2002. Thymic and extrathymic T cell development pathways follow different rules. J Immunol 169(2):684-92. [PubMed: 12097370]  [MGI Ref ID J:123838]

Thams S; Brodin P; Plantman S; Saxelin R; Karre K; Cullheim S. 2009. Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction. J Neurosci 29(43):13503-15. [PubMed: 19864563]  [MGI Ref ID J:158310]

Tikhonova AN; Van Laethem F; Hanada K; Lu J; Pobezinsky LA; Hong C; Guinter TI; Jeurling SK; Bernhardt G; Park JH; Yang JC; Sun PD; Singer A. 2012. alphabeta T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities. Immunity 36(1):79-91. [PubMed: 22209676]  [MGI Ref ID J:180750]

Tilloy F; Treiner E; Park SH; Garcia C; Lemonnier F; de la Salle H; Bendelac A; Bonneville M; Lantz O. 1999. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 189(12):1907-21. [PubMed: 10377186]  [MGI Ref ID J:55844]

Treiner E; Duban L; Bahram S; Radosavljevic M; Wanner V; Tilloy F; Affaticati P; Gilfillan S; Lantz O. 2003. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422(6928):164-9. [PubMed: 12634786]  [MGI Ref ID J:113083]

Tripathy SK; Keyel PA; Yang L; Pingel JT; Cheng TP; Schneeberger A; Yokoyama WM. 2008. Continuous engagement of a self-specific activation receptor induces NK cell tolerance. J Exp Med 205(8):1829-41. [PubMed: 18606857]  [MGI Ref ID J:138607]

Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. [PubMed: 23740949]  [MGI Ref ID J:205347]

Tsui H; Chan Y; Tang L; Winer S; Cheung RK; Paltser G; Selvanantham T; Elford AR; Ellis JR; Becker DJ; Ohashi PS; Dosch HM. 2008. Targeting of pancreatic glia in type 1 diabetes. Diabetes 57(4):918-28. [PubMed: 18198358]  [MGI Ref ID J:135214]

Tsuji-Kawahara S; Kawabata H; Matsukuma H; Kinoshita S; Chikaishi T; Sakamoto M; Kawasaki Y; Miyazawa M. 2013. Differential requirements of cellular and humoral immune responses for Fv2-associated resistance to erythroleukemia and for regulation of retrovirus-induced myeloid leukemia development. J Virol 87(24):13760-74. [PubMed: 24109240]  [MGI Ref ID J:205215]

Tsumiyama K; Hashiramoto A; Takimoto M; Tsuji-Kawahara S; Miyazawa M; Shiozawa S. 2013. IFN-gamma-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue. J Immunol 191(1):91-6. [PubMed: 23720810]  [MGI Ref ID J:205371]

Tyznik AJ; Sun JC; Bevan MJ. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 199(4):559-65. [PubMed: 14769854]  [MGI Ref ID J:90469]

Ueno A; Cho S; Cheng L; Wang Z; Wang B; Yang Y. 2005. Diabetes resistance/susceptibility in T cells of nonobese diabetic mice conferred by MHC and MHC-linked genes. J Immunol 175(8):5240-7. [PubMed: 16210629]  [MGI Ref ID J:119112]

Ueno T; Saito F; Gray DH; Kuse S; Hieshima K; Nakano H; Kakiuchi T; Lipp M; Boyd RL; Takahama Y. 2004. CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200(4):493-505. [PubMed: 15302902]  [MGI Ref ID J:93960]

Urdahl KB; Liggitt D; Bevan MJ. 2003. CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection. J Immunol 170(4):1987-94. [PubMed: 12574368]  [MGI Ref ID J:82297]

Van Den Broeck T; Stevenaert F; Taveirne S; Debacker V; Vangestel C; Vandekerckhove B; Taghon T; Matthys P; Plum J; Held W; Dewerchin M; Yokoyama WM; Leclercq G. 2008. Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. Blood 112(13):5046-51. [PubMed: 18784372]  [MGI Ref ID J:143621]

Van Laethem F; Sarafova SD; Park JH; Tai X; Pobezinsky L; Guinter TI; Adoro S; Adams A; Sharrow SO; Feigenbaum L; Singer A. 2007. Deletion of CD4 and CD8 Coreceptors Permits Generation of alphabetaT Cells that Recognize Antigens Independently of the MHC. Immunity 27(5):735-50. [PubMed: 18023370]  [MGI Ref ID J:127623]

Van Laethem F; Tikhonova AN; Pobezinsky LA; Tai X; Kimura MY; Le Saout C; Guinter TI; Adams A; Sharrow SO; Bernhardt G; Feigenbaum L; Singer A. 2013. Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154(6):1326-41. [PubMed: 24034254]  [MGI Ref ID J:204615]

Van de Keere F; Tonegawa S. 1998. CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 188(10):1875-82. [PubMed: 9815265]  [MGI Ref ID J:115028]

Verykokakis M; Boos MD; Bendelac A; Kee BL. 2010. SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Immunity 33(2):203-15. [PubMed: 20674402]  [MGI Ref ID J:163924]

Vesosky B; Rottinghaus EK; Davis C; Turner J. 2009. CD8 T Cells in old mice contribute to the innate immune response to Mycobacterium tuberculosis via interleukin-12p70-dependent and antigen-independent production of gamma interferon. Infect Immun 77(8):3355-63. [PubMed: 19470747]  [MGI Ref ID J:151445]

Vikingsson A; Pederson K; Muller D. 1996. Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice. Cell Immunol 173(2):261-8. [PubMed: 8912885]  [MGI Ref ID J:36758]

Wang B; Sharma A; Maile R; Saad M; Collins EJ; Frelinger JA. 2002. Peptidic termini play a significant role in TCR recognition. J Immunol 169(6):3137-45. [PubMed: 12218131]  [MGI Ref ID J:120444]

Wang D; Zheng M; Lei L; Ji J; Yao Y; Qiu Y; Ma L; Lou J; Ouyang C; Zhang X; He Y; Chi J; Wang L; Kuang Y; Wang J; Cao X; Lu L. 2012. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8. [PubMed: 22561606]  [MGI Ref ID J:186446]

Wei CH; Sherman LA. 2007. N-terminal trimer extension of nominal CD8 T cell epitopes is sufficient to promote cross-presentation to cognate CD8 T cells in vivo. J Immunol 179(12):8280-6. [PubMed: 18056372]  [MGI Ref ID J:155198]

Weidanz WP; Lafleur G; Brown A; Burns JM Jr; Gramaglia I; van der Heyde HC. 2010. {gamma}{delta} T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria. Infect Immun 78(10):4331-40. [PubMed: 20660608]  [MGI Ref ID J:164250]

Wells FB; Gahm SJ; Hedrick SM; Bluestone JA; Dent A; Matis LA. 1991. Requirement for positive selection of gamma delta receptor-bearing T cells. Science 253(5022):903-5. [PubMed: 1831565]  [MGI Ref ID J:113013]

White AJ; Withers DR; Parnell SM; Scott HS; Finke D; Lane PJ; Jenkinson EJ; Anderson G. 2008. Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input. Eur J Immunol 38(4):942-7. [PubMed: 18350550]  [MGI Ref ID J:133775]

Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60(6):1726-33. [PubMed: 21521873]  [MGI Ref ID J:177952]

Williams DM; Grubbs BG; Pack E; Kelly K; Rank RG. 1997. Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis. Infect Immun 65(7):2876-82. [PubMed: 9199462]  [MGI Ref ID J:41109]

Wilson EB; Parachoniak CA; Carpenito C; Mager DL; Takei F. 2007. Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1.1(+) T cells. Immunogenetics 59(8):641-51. [PubMed: 17516061]  [MGI Ref ID J:141918]

Winer DA; Winer S; Shen L; Wadia PP; Yantha J; Paltser G; Tsui H; Wu P; Davidson MG; Alonso MN; Leong HX; Glassford A; Caimol M; Kenkel JA; Tedder TF; McLaughlin T; Miklos DB; Dosch HM; Engleman EG. 2011. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17(5):610-7. [PubMed: 21499269]  [MGI Ref ID J:171607]

Wong KL; Lew FC; MacAry PA; Kemeny DM. 2008. CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur J Immunol 38(8):2251-62. [PubMed: 18600823]  [MGI Ref ID J:138592]

Wortham BW; Eppert BL; Motz GT; Flury JL; Orozco-Levi M; Hoebe K; Panos RJ; Maxfield M; Glasser SW; Senft AP; Raulet DH; Borchers MT. 2012. NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol 188(9):4468-75. [PubMed: 22467655]  [MGI Ref ID J:188448]

Wu X; Wang L; Schroer S; Choi D; Chen P; Okada H; Woo M. 2009. Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia :. [PubMed: 19644667]  [MGI Ref ID J:151770]

Xu S; Liu X; Bao Y; Zhu X; Han C; Zhang P; Zhang X; Li W; Cao X. 2012. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol 13(6):551-9. [PubMed: 22522491]  [MGI Ref ID J:186456]

Yamazaki C; Sugiyama M; Ohta T; Hemmi H; Hamada E; Sasaki I; Fukuda Y; Yano T; Nobuoka M; Hirashima T; Iizuka A; Sato K; Tanaka T; Hoshino K; Kaisho T. 2013. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol 190(12):6071-82. [PubMed: 23670193]  [MGI Ref ID J:204851]

Yin CC; Cho OH; Sylvia KE; Narayan K; Prince AL; Evans JW; Kang J; Berg LJ. 2013. The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of gammadelta NKT Cells. J Immunol 190(6):2659-69. [PubMed: 23378428]  [MGI Ref ID J:193616]

Yokote H; Miyake S; Croxford JL; Oki S; Mizusawa H; Yamamura T. 2008. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 173(6):1714-23. [PubMed: 18974295]  [MGI Ref ID J:143928]

Young HY; Zucker P; Flavell RA; Jevnikar AM; Singh B. 2004. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78(4):509-15. [PubMed: 15446308]  [MGI Ref ID J:107051]

Zanoni I; Spreafico R; Bodio C; Di Gioia M; Cigni C; Broggi A; Gorletta T; Caccia M; Chirico G; Sironi L; Collini M; Colombo MP; Garbi N; Granucci F. 2013. IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions. Cell Rep 4(6):1235-49. [PubMed: 24055061]  [MGI Ref ID J:203792]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zeng D; Gazit G; Dejbakhsh-Jones S; Balk SP; Snapper S; Taniguchi M; Strober S. 1999. Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus. J Immunol 163(10):5338-45. [PubMed: 10553057]  [MGI Ref ID J:58455]

Zhang B; Kracker S; Yasuda T; Casola S; Vanneman M; Homig-Holzel C; Wang Z; Derudder E; Li S; Chakraborty T; Cotter SE; Koyama S; Currie T; Freeman GJ; Kutok JL; Rodig SJ; Dranoff G; Rajewsky K. 2012. Immune Surveillance and Therapy of Lymphomas Driven by Epstein-Barr Virus Protein LMP1 in a Mouse Model. Cell 148(4):739-51. [PubMed: 22341446]  [MGI Ref ID J:181546]

Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. [PubMed: 15583018]  [MGI Ref ID J:94696]

Zhang Y; Rogers KH; Lewis DB. 1996. Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J Exp Med 184(4):1507-12. [PubMed: 8879221]  [MGI Ref ID J:39962]

Zhu X; Peng J; Raychowdhury R; Nakajima A; Lencer WI; Blumberg RS. 2002. The heavy chain of neonatal Fc receptor for IgG is sequestered in endoplasmic reticulum by forming oligomers in the absence of beta2-microglobulin association. Biochem J 367(Pt 3):703-14. [PubMed: 12162790]  [MGI Ref ID J:79983]

Zimmer J; Ioannidis V; Held W. 2001. H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: implications for NK cell function. J Exp Med 194(10):1531-9. [PubMed: 11714759]  [MGI Ref ID J:108568]

de Goer de Herve MG; Dembele B; Vallee M; Herr F; Cariou A; Taoufik Y. 2010. Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells. J Immunol 185(2):1028-36. [PubMed: 20562265]  [MGI Ref ID J:162023]

van Meerwijk JP; O'Connell EM; Germain RN. 1995. Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes. J Immunol 154(12):6314-23. [PubMed: 7759870]  [MGI Ref ID J:110813]

Il2rgtm1Wjl related

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]  [MGI Ref ID J:142410]

Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes. PLoS One 6(6):e20169. [PubMed: 21695116]  [MGI Ref ID J:174292]

Al-Shami A; Spolski R; Kelly J; Fry T; Schwartzberg PL; Pandey A; Mackall CL; Leonard WJ. 2004. A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med 200(2):159-68. [PubMed: 15263024]  [MGI Ref ID J:108209]

Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. [PubMed: 22937164]  [MGI Ref ID J:191672]

Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. [PubMed: 20668220]  [MGI Ref ID J:163262]

Arpke RW; Darabi R; Mader TL; Zhang Y; Toyama A; Lonetree CL; Nash N; Lowe DA; Perlingeiro RC; Kyba M. 2013. A New Immuno- Dystrophin-Deficient Model, the NSG-Mdx Mouse, Provides Evidence for Functional Improvement Following Allogeneic Satellite Cell Transplantation. Stem Cells :. [PubMed: 23606600]  [MGI Ref ID J:199729]

Ashkar AA; Black GP; Wei Q; He H; Liang L; Head JR; Croy BA. 2003. Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy. J Immunol 171(6):2937-44. [PubMed: 12960317]  [MGI Ref ID J:85375]

Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. [PubMed: 22065769]  [MGI Ref ID J:180174]

Baird JR; Byrne KT; Lizotte PH; Toraya-Brown S; Scarlett UK; Alexander MP; Sheen MR; Fox BA; Bzik DJ; Bosenberg M; Mullins DW; Turk MJ; Fiering S. 2013. Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge. J Immunol 190(1):469-78. [PubMed: 23225891]  [MGI Ref ID J:190812]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. [PubMed: 21266536]  [MGI Ref ID J:172780]

Bayer AL; Lee JY; de la Barrera A; Surh CD; Malek TR. 2008. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 181(1):225-34. [PubMed: 18566388]  [MGI Ref ID J:137409]

Berger A; Hoelbl-Kovacic A; Bourgeais J; Hoefling L; Warsch W; Grundschober E; Uras IZ; Menzl I; Putz EM; Hoermann G; Schuster C; Fajmann S; Leitner E; Kubicek S; Moriggl R; Gouilleux F; Sexl V. 2014. PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28(3):629-41. [PubMed: 24263804]  [MGI Ref ID J:206976]

Bertilaccio MT; Simonetti G; Dagklis A; Rocchi M; Rodriguez TV; Apollonio B; Mantovani A; Ponzoni M; Ghia P; Garlanda C; Caligaris-Cappio F; Muzio M. 2011. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 118(3):660-9. [PubMed: 21652674]  [MGI Ref ID J:174861]

Bezman NA; Chakraborty T; Bender T; Lanier LL. 2011. miR-150 regulates the development of NK and iNKT cells. J Exp Med 208(13):2717-31. [PubMed: 22124110]  [MGI Ref ID J:179053]

Billerbeck E; Barry WT; Mu K; Dorner M; Rice CM; Ploss A. 2011. Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R{gamma}null humanized mice. Blood 117(11):3076-86. [PubMed: 21252091]  [MGI Ref ID J:170510]

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. [PubMed: 23833235]  [MGI Ref ID J:205706]

Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. [PubMed: 22890824]  [MGI Ref ID J:191833]

Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. [PubMed: 20688981]  [MGI Ref ID J:167433]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. [PubMed: 22246028]  [MGI Ref ID J:180273]

Brickshawana A; Shapiro VS; Kita H; Pease LR. 2011. Lineage(-)Sca1+c-Kit(-)CD25+ cells are IL-33-responsive type 2 innate cells in the mouse bone marrow. J Immunol 187(11):5795-804. [PubMed: 22048767]  [MGI Ref ID J:179700]

Bucher C; Koch L; Vogtenhuber C; Goren E; Munger M; Panoskaltsis-Mortari A; Sivakumar P; Blazar BR. 2009. IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation. Blood 114(26):5375-84. [PubMed: 19843883]  [MGI Ref ID J:155701]

Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. [PubMed: 17681665]  [MGI Ref ID J:126691]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Burchill MA; Yang J; Vogtenhuber C; Blazar BR; Farrar MA. 2007. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 178(1):280-90. [PubMed: 17182565]  [MGI Ref ID J:141932]

Cao X; Shores EW; Hu-Li J; Anver MR; Kelsall BL; Russell SM; Drago J; Noguchi M; Grinberg A; Bloom ET; Paul WE; Katz SI; Love PE; Leonard WJ. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2(3):223-38. [PubMed: 7697543]  [MGI Ref ID J:24117]

Chappaz S; Finke D. 2010. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol 184(7):3562-9. [PubMed: 20207995]  [MGI Ref ID J:160069]

Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. [PubMed: 20016601]  [MGI Ref ID J:155800]

Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. [PubMed: 24474774]  [MGI Ref ID J:206650]

Cheng G; Yu A; Dee MJ; Malek TR. 2013. IL-2R Signaling Is Essential for Functional Maturation of Regulatory T Cells during Thymic Development. J Immunol 190(4):1567-75. [PubMed: 23315074]  [MGI Ref ID J:193324]

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Hoglund P; Jacobsen SE; Sitnicka E. 2009. Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development. J Immunol 182(3):1460-8. [PubMed: 19155493]  [MGI Ref ID J:144325]

Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. [PubMed: 23965627]  [MGI Ref ID J:205431]

Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. [PubMed: 21429805]  [MGI Ref ID J:173961]

Civenni G; Walter A; Kobert N; Mihic-Probst D; Zipser M; Belloni B; Seifert B; Moch H; Dummer R; van den Broek M; Sommer L. 2011. Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth. Cancer Res 71(8):3098-109. [PubMed: 21393506]  [MGI Ref ID J:170990]

Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. [PubMed: 23378057]  [MGI Ref ID J:196312]

Constantinides MG; McDonald BD; Verhoef PA; Bendelac A. 2014. A committed precursor to innate lymphoid cells. Nature :. [PubMed: 24509713]  [MGI Ref ID J:205609]

Cooper AB; Sawai CM; Sicinska E; Powers SE; Sicinski P; Clark MR; Aifantis I. 2006. A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97. [PubMed: 16582912]  [MGI Ref ID J:112393]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Crow AR; Song S; Semple JW; Freedman J; Lazarus AH. 2007. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg? Blood 109(1):155-8. [PubMed: 16954498]  [MGI Ref ID J:142178]

Danner R; Chaudhari SN; Rosenberger J; Surls J; Richie TL; Brumeanu TD; Casares S. 2011. Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells. PLoS One 6(5):e19826. [PubMed: 21611197]  [MGI Ref ID J:172588]

Darabi R; Gehlbach K; Bachoo RM; Kamath S; Osawa M; Kamm KE; Kyba M; Perlingeiro RC. 2008. Functional skeletal muscle regeneration from differentiating embryonic stem cells. Nat Med 14(2):134-43. [PubMed: 18204461]  [MGI Ref ID J:133565]

Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. [PubMed: 23430111]  [MGI Ref ID J:196692]

Davies E; Reid S; Medina MF; Lichty B; Ashkar AA. 2010. IL-15 has innate anti-tumor activity independent of NK and CD8 T cells. J Leukoc Biol 88(3):529-36. [PubMed: 20538758]  [MGI Ref ID J:164922]

Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. [PubMed: 23896410]  [MGI Ref ID J:202360]

Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. [PubMed: 22593616]  [MGI Ref ID J:188965]

Eidenschenk C; Crozat K; Krebs P; Arens R; Popkin D; Arnold CN; Blasius AL; Benedict CA; Moresco EM; Xia Y; Beutler B. 2010. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A :. [PubMed: 20457904]  [MGI Ref ID J:159599]

Eisenring M; vom Berg J; Kristiansen G; Saller E; Becher B. 2010. IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46. Nat Immunol 11(11):1030-8. [PubMed: 20935648]  [MGI Ref ID J:166535]

El Haddad N; Heathcote D; Moore R; Yang S; Azzi J; Mfarrej B; Atkinson M; Sayegh MH; Lee JS; Ashton-Rickardt PG; Abdi R. 2011. Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood 117(4):1176-83. [PubMed: 21076046]  [MGI Ref ID J:168605]

Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. [PubMed: 22617213]  [MGI Ref ID J:185539]

Feng CG; Kaviratne M; Rothfuchs AG; Cheever A; Hieny S; Young HA; Wynn TA; Sher A. 2006. NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol 177(10):7086-93. [PubMed: 17082625]  [MGI Ref ID J:140483]

Fiorini E; Ferrero I; Merck E; Favre S; Pierres M; Luther SA; MacDonald HR. 2008. Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells. J Immunol 181(12):8199-203. [PubMed: 19050235]  [MGI Ref ID J:142081]

Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. [PubMed: 23467088]  [MGI Ref ID J:194916]

Fontenot JD; Rasmussen JP; Gavin MA; Rudensky AY. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6(11):1142-51. [PubMed: 16227984]  [MGI Ref ID J:112602]

Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. [PubMed: 20729912]  [MGI Ref ID J:166563]

Gill N; Rosenthal KL; Ashkar AA. 2005. NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J Virol 79(7):4470-8. [PubMed: 15767447]  [MGI Ref ID J:97038]

Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. [PubMed: 20671189]  [MGI Ref ID J:162606]

Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. [PubMed: 20495069]  [MGI Ref ID J:161304]

Guimond M; Leonard WJ; Spolski R; Rossi SW; Veenstra RG; Hollander GA; Mackall CL; Blazar BR. 2008. Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood 111(2):969-70. [PubMed: 18182587]  [MGI Ref ID J:130979]

Guimond M; Veenstra RG; Grindler DJ; Zhang H; Cui Y; Murphy RD; Kim SY; Na R; Hennighausen L; Kurtulus S; Erman B; Matzinger P; Merchant MS; Mackall CL. 2009. Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells. Nat Immunol 10(2):149-57. [PubMed: 19136960]  [MGI Ref ID J:144504]

Gurish MF; Tao H; Abonia JP; Arya A; Friend DS; Parker CM; Austen KF. 2001. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med 194(9):1243-52. [PubMed: 11696590]  [MGI Ref ID J:119138]

Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. [PubMed: 23925295]  [MGI Ref ID J:201617]

Hao J; Shi FD; Abdelwahab M; Shi SX; Simard A; Whiteaker P; Lukas R; Zhou Q. 2013. Nicotinic receptor beta2 determines NK cell-dependent metastasis in a murine model of metastatic lung cancer. PLoS One 8(2):e57495. [PubMed: 23469004]  [MGI Ref ID J:197263]

Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. [PubMed: 22464800]  [MGI Ref ID J:189339]

Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. [PubMed: 20068223]  [MGI Ref ID J:162612]

Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. [PubMed: 19324903]  [MGI Ref ID J:148898]

Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. [PubMed: 22343031]  [MGI Ref ID J:184937]

Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. [PubMed: 20601939]  [MGI Ref ID J:162607]

Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. [PubMed: 21926352]  [MGI Ref ID J:178783]

Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. [PubMed: 22753496]  [MGI Ref ID J:186492]

Imtiyaz HZ; Zhou X; Zhang H; Chen D; Hu T; Zhang J. 2009. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation. J Biol Chem 284(15):9917-26. [PubMed: 19203997]  [MGI Ref ID J:149068]

Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. [PubMed: 22558161]  [MGI Ref ID J:187283]

Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. [PubMed: 15920010]  [MGI Ref ID J:142411]

Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. [PubMed: 19802382]  [MGI Ref ID J:154110]

Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. [PubMed: 20072130]  [MGI Ref ID J:162611]

Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. [PubMed: 20505160]  [MGI Ref ID J:163485]

Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. [PubMed: 18852293]  [MGI Ref ID J:141103]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Karst AM; Levanon K; Drapkin R. 2011. Modeling high-grade serous ovarian carcinogenesis from the fallopian tube. Proc Natl Acad Sci U S A 108(18):7547-52. [PubMed: 21502498]  [MGI Ref ID J:172047]

Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. [PubMed: 22897850]  [MGI Ref ID J:191823]

Kelly J; Spolski R; Imada K; Bollenbacher J; Lee S; Leonard WJ. 2003. A role for stat5 in CD8(+) T cell homeostasis. J Immunol 170(1):210-7. [PubMed: 12496402]  [MGI Ref ID J:80897]

Kim HJ; Verbinnen B; Tang X; Lu L; Cantor H. 2010. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 467(7313):328-32. [PubMed: 20844537]  [MGI Ref ID J:164663]

Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. [PubMed: 21873530]  [MGI Ref ID J:179333]

Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. [PubMed: 23300950]  [MGI Ref ID J:195822]

Klose CS; Kiss EA; Schwierzeck V; Ebert K; Hoyler T; d'Hargues Y; Goppert N; Croxford AL; Waisman A; Tanriver Y; Diefenbach A. 2013. A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature 494(7436):261-5. [PubMed: 23334414]  [MGI Ref ID J:194555]

Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. [PubMed: 24209604]  [MGI Ref ID J:206743]

Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. [PubMed: 22664870]  [MGI Ref ID J:188934]

Krueger A; von Boehmer H. 2007. Identification of a T lineage-committed progenitor in adult blood. Immunity 26(1):105-16. [PubMed: 17222572]  [MGI Ref ID J:118201]

Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PubMed: 18691745]  [MGI Ref ID J:142409]

Kuroda-Morimoto M; Tanaka H; Hayashi N; Nakahira M; Imai Y; Imamura M; Yasuda K; Yumikura-Futatsugi S; Matsui K; Nakashima T; Sugimura K; Tsutsui H; Sano H; Nakanishi K. 2010. Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins. Int Immunol 22(7):561-70. [PubMed: 20497957]  [MGI Ref ID J:161302]

Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. [PubMed: 23686485]  [MGI Ref ID J:204842]

Li L; Wang L; Li L; Wang Z; Ho Y; McDonald T; Holyoake TL; Chen W; Bhatia R. 2012. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib. Cancer Cell 21(2):266-81. [PubMed: 22340598]  [MGI Ref ID J:181458]

Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. [PubMed: 20713716]  [MGI Ref ID J:163745]

Long BR; Stoddart CA. 2012. Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice. J Virol 86(6):3327-36. [PubMed: 22238321]  [MGI Ref ID J:181199]

Lu L; Ikizawa K; Hu D; Werneck MB; Wucherpfennig KW; Cantor H. 2007. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 26(5):593-604. [PubMed: 17509909]  [MGI Ref ID J:123555]

Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. [PubMed: 19481135]  [MGI Ref ID J:151435]

Ma S; Shukla V; Fang L; Gould KA; Joshi SS; Lu R. 2013. Accelerated development of chronic lymphocytic leukemia in New Zealand Black mice expressing a low level of interferon regulatory factor 4. J Biol Chem 288(37):26430-40. [PubMed: 23897826]  [MGI Ref ID J:203533]

Ma S; Turetsky A; Trinh L; Lu R. 2006. IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development. J Immunol 177(11):7898-904. [PubMed: 17114461]  [MGI Ref ID J:140693]

Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. [PubMed: 20472832]  [MGI Ref ID J:164541]

Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. [PubMed: 18371405]  [MGI Ref ID J:142413]

Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. [PubMed: 23659714]  [MGI Ref ID J:202643]

Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. [PubMed: 22072769]  [MGI Ref ID J:179389]

Martinez-Forero I; Azpilikueta A; Bolanos-Mateo E; Nistal-Villan E; Palazon A; Teijeira A; Perez-Chacon G; Morales-Kastresana A; Murillo O; Jure-Kunkel M; Zapata JM; Melero I. 2013. T cell costimulation with anti-CD137 monoclonal antibodies is mediated by K63-polyubiquitin-dependent signals from endosomes. J Immunol 190(12):6694-706. [PubMed: 23690480]  [MGI Ref ID J:204832]

Martins VC; Ruggiero E; Schlenner SM; Madan V; Schmidt M; Fink PJ; von Kalle C; Rodewald HR. 2012. Thymus-autonomous T cell development in the absence of progenitor import. J Exp Med 209(8):1409-17. [PubMed: 22778389]  [MGI Ref ID J:189166]

Masse GX; Corcuff E; Decaluwe H; Bommhardt U; Lantz O; Buer J; Di Santo JP. 2007. gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells. Eur J Immunol 37(9):2606-16. [PubMed: 17683114]  [MGI Ref ID J:124346]

McCaughtry TM; Etzensperger R; Alag A; Tai X; Kurtulus S; Park JH; Grinberg A; Love P; Feigenbaum L; Erman B; Singer A. 2012. Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med 209(12):2263-76. [PubMed: 23109710]  [MGI Ref ID J:190889]

McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. [PubMed: 20404133]  [MGI Ref ID J:162809]

Merck E; Voyle RB; MacDonald HR. 2009. Ly49D engagement on T lymphocytes induces TCR-independent activation and CD8 effector functions that control tumor growth. J Immunol 182(1):183-92. [PubMed: 19109149]  [MGI Ref ID J:143041]

Mintern JD; Maurice MM; Ploegh HL; Schott E. 2004. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. J Immunol 172(1):699-708. [PubMed: 14688383]  [MGI Ref ID J:87075]

Moro K; Yamada T; Tanabe M; Takeuchi T; Ikawa T; Kawamoto H; Furusawa J; Ohtani M; Fujii H; Koyasu S. 2010. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463(7280):540-4. [PubMed: 20023630]  [MGI Ref ID J:156764]

Morris SC; Orekhova T; Meadows MJ; Heidorn SM; Yang J; Finkelman FD. 2006. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176(9):5299-305. [PubMed: 16621996]  [MGI Ref ID J:131660]

Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. [PubMed: 19535452]  [MGI Ref ID J:153922]

Mukai K; Matsuoka K; Taya C; Suzuki H; Yokozeki H; Nishioka K; Hirokawa K; Etori M; Yamashita M; Kubota T; Minegishi Y; Yonekawa H; Karasuyama H. 2005. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23(2):191-202. [PubMed: 16111637]  [MGI Ref ID J:100537]

Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. [PubMed: 22791816]  [MGI Ref ID J:192954]

Nakajima H; Leonard WJ. 1997. Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice. J Immunol 159(10):4737-44. [PubMed: 9366397]  [MGI Ref ID J:43962]

Nakajima H; Leonard WJ. 1999. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: the requirement for Bcl-2 differs depending on the TCR/MHC affinity. J Immunol 162(2):782-90. [PubMed: 9916699]  [MGI Ref ID J:52019]

Nakajima H; Shores EW; Noguchi M; Leonard WJ. 1997. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J Exp Med 185(2):189-95. [PubMed: 9016868]  [MGI Ref ID J:107159]

Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. [PubMed: 20805496]  [MGI Ref ID J:164365]

Nolte T; Zadeh-Khorasani M; Safarov O; Rueff F; Varga R; Herbach N; Wanke R; Wollenberg A; Mueller T; Gropp R; Wolf E; Siebeck M. 2013. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rgamma(null) mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech 6(1):125-34. [PubMed: 22822046]  [MGI Ref ID J:192789]

Nozad Charoudeh H; Tang Y; Cheng M; Cilio CM; Jacobsen SE; Sitnicka E. 2010. Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells. Blood 116(2):183-92. [PubMed: 20421450]  [MGI Ref ID J:162802]

O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. [PubMed: 22392992]  [MGI Ref ID J:182231]

O'Leary JG; Goodarzi M; Drayton DL; von Andrian UH. 2006. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7(5):507-16. [PubMed: 16617337]  [MGI Ref ID J:112596]

O'Sullivan T; Saddawi-Konefka R; Vermi W; Koebel CM; Arthur C; White JM; Uppaluri R; Andrews DM; Ngiow SF; Teng MW; Smyth MJ; Schreiber RD; Bui JD. 2012. Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med 209(10):1869-82. [PubMed: 22927549]  [MGI Ref ID J:192935]

Ohteki T; Suzue K; Maki C; Ota T; Koyasu S. 2001. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol 2(12):1138-43. [PubMed: 11702064]  [MGI Ref ID J:125660]

Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. [PubMed: 22430210]  [MGI Ref ID J:193369]

Orr SJ; Roessler S; Quigley L; Chan T; Ford JW; O'Connor GM; McVicar DW. 2010. Implications for gene therapy-limiting expression of IL-2Rgammac delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol 185(3):1393-403. [PubMed: 20592278]  [MGI Ref ID J:162459]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Ozturk F; Li Y; Zhu X; Guda C; Nawshad A. 2013. Systematic analysis of palatal transcriptome to identify cleft palate genes within TGFbeta3-knockout mice alleles: RNA-Seq analysis of TGFbeta3 Mice. BMC Genomics 14:113. [PubMed: 23421592]  [MGI Ref ID J:196701]

Paust S; Gill HS; Wang BZ; Flynn MP; Moseman EA; Senman B; Szczepanik M; Telenti A; Askenase PW; Compans RW; von Andrian UH. 2010. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol 11(12):1127-35. [PubMed: 20972432]  [MGI Ref ID J:167327]

Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. [PubMed: 18491294]  [MGI Ref ID J:151386]

Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PubMed: 18563383]  [MGI Ref ID J:138005]

Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. [PubMed: 18785974]  [MGI Ref ID J:140388]

Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. [PubMed: 22340590]  [MGI Ref ID J:181463]

Porcellini S; Traggiai E; Schenk U; Ferrera D; Matteoli M; Lanzavecchia A; Michalak M; Grassi F. 2006. Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-71. [PubMed: 16492806]  [MGI Ref ID J:119147]

Porter BO; Malek TR. 1999. IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development. J Immunol 163(11):5906-12. [PubMed: 10570276]  [MGI Ref ID J:58655]

Price AE; Liang HE; Sullivan BM; Reinhardt RL; Eisley CJ; Erle DJ; Locksley RM. 2010. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A 107(25):11489-94. [PubMed: 20534524]  [MGI Ref ID J:161387]

Putz EM; Gotthardt D; Hoermann G; Csiszar A; Wirth S; Berger A; Straka E; Rigler D; Wallner B; Jamieson AM; Pickl WF; Zebedin-Brandl EM; Muller M; Decker T; Sexl V. 2013. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep 4(3):437-44. [PubMed: 23933255]  [MGI Ref ID J:201893]

Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. [PubMed: 19052619]  [MGI Ref ID J:142408]

Ramirez-Carrozzi V; Sambandam A; Luis E; Lin Z; Jeet S; Lesch J; Hackney J; Kim J; Zhou M; Lai J; Modrusan Z; Sai T; Lee W; Xu M; Caplazi P; Diehl L; de Voss J; Balazs M; Gonzalez L Jr; Singh H; Ouyang W; Pappu R. 2011. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol 12(12):1159-66. [PubMed: 21993848]  [MGI Ref ID J:178967]

Ramsey C; Rubinstein MP; Kim DM; Cho JH; Sprent J; Surh CD. 2008. The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15. J Immunol 180(8):5320-6. [PubMed: 18390713]  [MGI Ref ID J:134238]

Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. [PubMed: 22542847]  [MGI Ref ID J:184798]

Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. [PubMed: 21209895]  [MGI Ref ID J:168312]

Rosenberger CM; Clark AE; Treuting PM; Johnson CD; Aderem A. 2008. ATF3 regulates MCMV infection in mice by modulating IFN-gamma expression in natural killer cells. Proc Natl Acad Sci U S A 105(7):2544-9. [PubMed: 18268321]  [MGI Ref ID J:132172]

Rothfuchs AG; Trumstedt C; Wigzell H; Rottenberg ME. 2004. Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling. J Immunol 172(10):6345-53. [PubMed: 15128825]  [MGI Ref ID J:89856]

Sabet-Baktach M; Eggenhofer E; Rovira J; Renner P; Lantow M; Farkas SA; Malaise M; Edtinger K; Shaotang Z; Koehl GE; Dahlke MH; Schlitt HJ; Geissler EK; Kroemer A. 2013. Double deficiency for RORgammat and T-bet drives Th2-mediated allograft rejection in mice. J Immunol 191(8):4440-6. [PubMed: 24058178]  [MGI Ref ID J:206252]

Saint Fleur S; Hoshino A; Kondo K; Egawa T; Fujii H. 2009. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood 114(7):1355-65. [PubMed: 19528538]  [MGI Ref ID J:151722]

Sander S; Calado DP; Srinivasan L; Kochert K; Zhang B; Rosolowski M; Rodig SJ; Holzmann K; Stilgenbauer S; Siebert R; Bullinger L; Rajewsky K. 2012. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Cancer Cell 22(2):167-79. [PubMed: 22897848]  [MGI Ref ID J:191824]

Sanos SL; Bui VL; Mortha A; Oberle K; Heners C; Johner C; Diefenbach A. 2009. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 10(1):83-91. [PubMed: 19029903]  [MGI Ref ID J:142348]

Schwab I; Biburger M; Kronke G; Schett G; Nimmerjahn F. 2012. IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1. Eur J Immunol 42(4):826-30. [PubMed: 22278120]  [MGI Ref ID J:187786]

Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. [PubMed: 19636062]  [MGI Ref ID J:152910]

Shukla V; Ma S; Hardy RR; Joshi SS; Lu R. 2013. A role for IRF4 in the development of CLL. Blood 122(16):2848-55. [PubMed: 23926303]  [MGI Ref ID J:203270]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151]  [MGI Ref ID J:109833]

Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. [PubMed: 20615947]  [MGI Ref ID J:162315]

Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. [PubMed: 18453623]  [MGI Ref ID J:142412]

Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. [PubMed: 22371883]  [MGI Ref ID J:183769]

Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. [PubMed: 23643966]  [MGI Ref ID J:202381]

Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. [PubMed: 20671122]  [MGI Ref ID J:167434]

Strowig T; Gurer C; Ploss A; Liu YF; Arrey F; Sashihara J; Koo G; Rice CM; Young JW; Chadburn A; Cohen JI; Munz C. 2009. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 206(6):1423-34. [PubMed: 19487422]  [MGI Ref ID J:149509]

Suzuki K; Nakajima H; Saito Y; Saito T; Leonard WJ; Iwamoto I. 2000. Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice. Int Immunol 12(2):123-32. [PubMed: 10653847]  [MGI Ref ID J:60418]

Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. [PubMed: 20634377]  [MGI Ref ID J:165866]

Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. [PubMed: 22279057]  [MGI Ref ID J:180274]

Takatori H; Kanno Y; Watford WT; Tato CM; Weiss G; Ivanov II; Littman DR; O'Shea JJ. 2009. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206(1):35-41. [PubMed: 19114665]  [MGI Ref ID J:144034]

Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. [PubMed: 22611244]  [MGI Ref ID J:188959]

Taylor JJ; Martinez RJ; Titcombe PJ; Barsness LO; Thomas SR; Zhang N; Katzman SD; Jenkins MK; Mueller DL. 2012. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J Exp Med 209(11):2065-77. [PubMed: 23071255]  [MGI Ref ID J:190897]

Taylor RT; Lugering A; Newell KA; Williams IR. 2004. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol 173(12):7183-9. [PubMed: 15585839]  [MGI Ref ID J:94865]

Thomas MF; Abdul-Wajid S; Panduro M; Babiarz JE; Rajaram M; Woodruff P; Lanier LL; Heissmeyer V; Ansel KM. 2012. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood 120(1):130-42. [PubMed: 22613798]  [MGI Ref ID J:189125]

Thomas SY; Scanlon ST; Griewank KG; Constantinides MG; Savage AK; Barr KA; Meng F; Luster AD; Bendelac A. 2011. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med 208(6):1179-88. [PubMed: 21624939]  [MGI Ref ID J:176822]

Tolar J; Wang X; Braunlin E; McElmurry RT; Nakamura Y; Bell S; Xia L; Zhang J; Hu Q; Panoskaltsis-Mortari A; Zhang J; Blazar BR. 2007. The host immune response is essential for the beneficial effect of adult stem cells after myocardial ischemia. Exp Hematol 35(4):682-90. [PubMed: 17379078]  [MGI Ref ID J:123112]

Touma M; Sun ZY; Clayton LK; Marissen WE; Kruisbeek AM; Wagner G; Reinherz EL. 2007. Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly. J Immunol 178(6):3668-79. [PubMed: 17339464]  [MGI Ref ID J:144281]

Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. [PubMed: 19369639]  [MGI Ref ID J:151270]

Veinotte LL; Halim TY; Takei F. 2008. Unique subset of natural killer cells develops from progenitors in lymph node. Blood 111(8):4201-8. [PubMed: 18227350]  [MGI Ref ID J:134359]

Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. [PubMed: 21875955]  [MGI Ref ID J:177573]

Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. [PubMed: 20430958]  [MGI Ref ID J:162797]

Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. [PubMed: 24516154]  [MGI Ref ID J:206819]

Waskow C; Bartels S; Schlenner SM; Costa C; Rodewald HR. 2007. Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood 109(12):5363-70. [PubMed: 17327401]  [MGI Ref ID J:145426]

Wei C; Zeff R; Goldschneider I. 2000. Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. J Immunol 164(4):1961-70. [PubMed: 10657646]  [MGI Ref ID J:60331]

White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. [PubMed: 22406538]  [MGI Ref ID J:184554]

Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60(6):1726-33. [PubMed: 21521873]  [MGI Ref ID J:177952]

Wilhelm C; Hirota K; Stieglitz B; Van Snick J; Tolaini M; Lahl K; Sparwasser T; Helmby H; Stockinger B. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12(11):1071-7. [PubMed: 21983833]  [MGI Ref ID J:177640]

Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123(3):1032-43. [PubMed: 23454765]  [MGI Ref ID J:196378]

Wu X; Kastin AJ; Hsuchou H; Pan W. 2010. The effects of IL2Rgamma knockout on depression and contextual memory. Behav Brain Res 213(2):319-22. [PubMed: 20438766]  [MGI Ref ID J:161861]

Wunderlich M; Chou FS; Link KA; Mizukawa B; Perry RL; Carroll M; Mulloy JC. 2010. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 24(10):1785-8. [PubMed: 20686503]  [MGI Ref ID J:166359]

Xie Y; Akpinarli A; Maris C; Hipkiss EL; Lane M; Kwon EK; Muranski P; Restifo NP; Antony PA. 2010. Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma. J Exp Med 207(3):651-67. [PubMed: 20156973]  [MGI Ref ID J:158128]

XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. [PubMed: 19805087]  [MGI Ref ID J:153698]

Yamaoka K; Min B; Zhou YJ; Paul WE; O'shea JJ. 2005. Jak3 negatively regulates dendritic-cell cytokine production and survival. Blood 106(9):3227-33. [PubMed: 16020505]  [MGI Ref ID J:123902]

Yamauchi T; Takenaka K; Urata S; Shima T; Kikushige Y; Tokuyama T; Iwamoto C; Nishihara M; Iwasaki H; Miyamoto T; Honma N; Nakao M; Matozaki T; Akashi K. 2013. Polymorphic Sirpa is the genetic determinant for NOD-based mouse lines to achieve efficient human cell engraftment. Blood 121(8):1316-25. [PubMed: 23293079]  [MGI Ref ID J:194763]

Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. [PubMed: 21724588]  [MGI Ref ID J:175446]

Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. [PubMed: 23348745]  [MGI Ref ID J:194482]

Yu G; Xu X; Vu MD; Kilpatrick ED; Li XC. 2006. NK cells promote transplant tolerance by killing donor antigen-presenting cells. J Exp Med 203(8):1851-8. [PubMed: 16864660]  [MGI Ref ID J:124395]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zecher D; Li Q; Oberbarnscheidt MH; Demetris AJ; Shlomchik WD; Rothstein DM; Lakkis FG. 2010. NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells. J Immunol 184(12):6649-57. [PubMed: 20483732]  [MGI Ref ID J:161405]

Zenewicz LA; Yancopoulos GD; Valenzuela DM; Murphy AJ; Stevens S; Flavell RA. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29(6):947-57. [PubMed: 19100701]  [MGI Ref ID J:142640]

Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. [PubMed: 20478526]  [MGI Ref ID J:160523]

Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. [PubMed: 21368761]  [MGI Ref ID J:170816]

Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. [PubMed: 20668064]  [MGI Ref ID J:164245]

Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. [PubMed: 20691153]  [MGI Ref ID J:164900]

Zhou S; Mody D; DeRavin SS; Hauer J; Lu T; Ma Z; Hacein-Bey Abina S; Gray JT; Greene MR; Cavazzana-Calvo M; Malech HL; Sorrentino BP. 2010. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood 116(6):900-8. [PubMed: 20457870]  [MGI Ref ID J:163500]

van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. [PubMed: 23690475]  [MGI Ref ID J:204834]

Prkdcscid related

Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. Blood 116(12):2103-11. [PubMed: 20554971]  [MGI Ref ID J:164507]

Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer 123(9):2222-7. [PubMed: 18688847]  [MGI Ref ID J:142410]

Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma. Br J Haematol 89(2):319-27. [PubMed: 7873382]  [MGI Ref ID J:22989]

Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340-8. [PubMed: 16081804]  [MGI Ref ID J:107507]

Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. Int Immunol 10(1):17-25. [PubMed: 9488152]  [MGI Ref ID J:110480]

Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice. J Immunol 173(11):6667-75. [PubMed: 15557158]  [MGI Ref ID J:94366]

Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A 105(47):18366-71. [PubMed: 19017790]  [MGI Ref ID J:142215]

Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype. PLoS One 7(8):e44219. [PubMed: 22937164]  [MGI Ref ID J:191672]

Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649]  [MGI Ref ID J:125443]

Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res 66(15):7734-40. [PubMed: 16885376]  [MGI Ref ID J:112102]

Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol 188(10):4792-800. [PubMed: 22516957]  [MGI Ref ID J:188666]

Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P. 1999. Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice. J Clin Invest 103(8):1201-9. [PubMed: 10207172]  [MGI Ref ID J:108737]

Anders K; Buschow C; Herrmann A; Milojkovic A; Loddenkemper C; Kammertoens T; Daniel P; Yu H; Charo J; Blankenstein T. 2011. Oncogene-Targeting T Cells Reject Large Tumors while Oncogene Inactivation Selects Escape Variants in Mouse Models of Cancer. Cancer Cell 20(6):755-67. [PubMed: 22172721]  [MGI Ref ID J:178597]

Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice. Infect Immun 75(7):3245-55. [PubMed: 17438029]  [MGI Ref ID J:122426]

Andre MC; Erbacher A; Gille C; Schmauke V; Goecke B; Hohberger A; Mang P; Wilhelm A; Mueller I; Herr W; Lang P; Handgretinger R; Hartwig UF. 2010. Long-term human CD34(+) stem cell-engrafted nonobese diabetic/SCID/IL-2Rgamma(null) mice show impaired CD8(+) T cell maintenance and a functional arrest of immature NK cells. J Immunol 185(5):2710-20. [PubMed: 20668220]  [MGI Ref ID J:163262]

Araki R; Fujimori A; Hamatani K; Mita K; Saito T; Mori M; Fukumura R; Morimyo M; Muto M; Itoh M; Tatsumi K; Abe M. 1997. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc Natl Acad Sci U S A 94(6):2438-43. [PubMed: 9122213]  [MGI Ref ID J:39329]

Archer NK; Harro JM; Shirtliff ME. 2013. Clearance of Staphylococcus aureus nasal carriage is T cell dependent and mediated through interleukin-17A expression and neutrophil influx. Infect Immun 81(6):2070-5. [PubMed: 23529621]  [MGI Ref ID J:199531]

Arendt LM; McCready J; Keller PJ; Baker DD; Naber SP; Seewaldt V; Kuperwasser C. 2013. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res 73(19):6080-93. [PubMed: 23959857]  [MGI Ref ID J:202607]

Ashkar AA; Di Santo JP; Croy BA. 2000. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy [see comments] J Exp Med 192(2):259-70. [PubMed: 10899912]  [MGI Ref ID J:63645]

Aspord C; Rome S; Thivolet C. 2004. Early events in islets and pancreatic lymph nodes in autoimmune diabetes. J Autoimmun 23(1):27-35. [PubMed: 15236750]  [MGI Ref ID J:91668]

Augstein P; Stephens LA; Allison J; Elefanty AG; Ekberg M; Kay TW; Harrison LC. 1998. Beta-cell apoptosis in an accelerated model of autoimmune diabetes. Mol Med 4(8):495-501. [PubMed: 9742505]  [MGI Ref ID J:133840]

Babu S; Porte P; Klei TR; Shultz LD; Rajan TV. 1998. Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice. J Immunol 161(3):1428-32. [PubMed: 9686607]  [MGI Ref ID J:49819]

Baerenwaldt A; Lux A; Danzer H; Spriewald BM; Ullrich E; Heidkamp G; Dudziak D; Nimmerjahn F. 2011. Fcgamma receptor IIB (FcgammaRIIB) maintains humoral tolerance in the human immune system in vivo. Proc Natl Acad Sci U S A 108(46):18772-7. [PubMed: 22065769]  [MGI Ref ID J:180174]

Baker RL; Delong T; Barbour G; Bradley B; Nakayama M; Haskins K. 2013. Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol 191(8):3990-4. [PubMed: 24043895]  [MGI Ref ID J:206266]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Balavenkatraman KK; Aceto N; Britschgi A; Mueller U; Bence KK; Neel BG; Bentires-Alj M. 2011. Epithelial protein-tyrosine phosphatase 1B contributes to the induction of mammary tumors by HER2/Neu but is not essential for tumor maintenance. Mol Cancer Res 9(10):1377-84. [PubMed: 21849469]  [MGI Ref ID J:205401]

Baleriola J; Suarez T; de la Rosa EJ. 2010. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ 17(11):1697-706. [PubMed: 20448641]  [MGI Ref ID J:186357]

Ballas ZK; Buchta CM; Rosean TR; Heusel JW; Shey MR. 2013. Role of NK cell subsets in organ-specific murine melanoma metastasis. PLoS One 8(6):e65599. [PubMed: 23776508]  [MGI Ref ID J:204234]

Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. [PubMed: 21576342]  [MGI Ref ID J:173478]

Bandi S; Joseph B; Berishvili E; Singhania R; Wu YM; Cheng K; Gupta S. 2011. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Am J Pathol 178(1):161-74. [PubMed: 21224054]  [MGI Ref ID J:168235]

Banerjee P; Tripp A; Lairmore MD; Crawford L; Sieburg M; Ramos JC; Harrington W Jr; Beilke MA; Feuer G. 2010. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood 115(13):2640-8. [PubMed: 20124219]  [MGI Ref ID J:162610]

Banga SS; Hall KT; Sandhu AK; Weaver DT; Athwal RS. 1994. Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8. Mutat Res 315(3):239-47. [PubMed: 7526201]  [MGI Ref ID J:21219]

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. [PubMed: 15308121]  [MGI Ref ID J:91764]

Bao L; Haas M; Pippin J; Wang Y; Miwa T; Chang A; Minto AW; Petkova M; Qiao G; Song WC; Alpers CE; Zhang J; Shankland SJ; Quigg RJ. 2009. Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells. J Clin Invest 119(5):1264-74. [PubMed: 19349693]  [MGI Ref ID J:149592]

Barber RC; Miccoli L; van Buul PP; Burr KL; van Duyn-Goedhart A; Angulo JF; Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat Res 554(1-2):287-95. [PubMed: 15450426]  [MGI Ref ID J:93788]

Bardeesy N; Kim M; Xu J; Kim RS; Shen Q; Bosenberg MW; Wong WH; Chin L. 2005. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol 25(10):4176-88. [PubMed: 15870287]  [MGI Ref ID J:99136]

Barrette B; Hebert MA; Filali M; Lafortune K; Vallieres N; Gowing G; Julien JP; Lacroix S. 2008. Requirement of myeloid cells for axon regeneration. J Neurosci 28(38):9363-76. [PubMed: 18799670]  [MGI Ref ID J:142759]

Barroso-delJesus A; Lucena-Aguilar G; Sanchez L; Ligero G; Gutierrez-Aranda I; Menendez P. 2011. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. FASEB J 25(5):1497-508. [PubMed: 21266536]  [MGI Ref ID J:172780]

Barthold SW; Hodzic E; Tunev S; Feng S. 2006. Antibody-mediated disease remission in the mouse model of lyme borreliosis. Infect Immun 74(8):4817-25. [PubMed: 16861670]  [MGI Ref ID J:112329]

Battaglia M; Stabilini A; Draghici E; Migliavacca B; Gregori S; Bonifacio E; Roncarolo MG. 2006. Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells. Diabetes 55(6):1571-80. [PubMed: 16731819]  [MGI Ref ID J:111884]

Beamer WG; Shultz KL; Tennent BJ; Shultz LD. 1993. Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors. Cancer Res 53(16):3741-6. [PubMed: 8339285]  [MGI Ref ID J:14443]

Belkaid Y; Mendez S; Lira R; Kadambi N; Milon G; Sacks D. 2000. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity. J Immunol 165(2):969-77. [PubMed: 10878373]  [MGI Ref ID J:120233]

Bellani MA; Romanienko PJ; Cairatti DA; Camerini-Otero RD. 2005. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. J Cell Sci 118(Pt 15):3233-45. [PubMed: 15998665]  [MGI Ref ID J:100203]

Bello-Irizarry SN; Wang J; Johnston CJ; Gigliotti F; Wright TW. 2014. MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection. J Immunol 192(1):282-92. [PubMed: 24293628]  [MGI Ref ID J:207087]

Benner EJ; Banerjee R; Reynolds AD; Sherman S; Pisarev VM; Tsiperson V; Nemachek C; Ciborowski P; Przedborski S; Mosley RL; Gendelman HE. 2008. Nitrated alpha-Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons. PLoS ONE 3(1):e1376. [PubMed: 18167537]  [MGI Ref ID J:131300]

Bertin A. 1992. Comparison of susceptibility of inbred and outbred infant mice to Escherichia coli heat-stable enterotoxin STa. Infect Immun 60(8):3117-21. [PubMed: 1639480]  [MGI Ref ID J:2117]

Bettini M; Castellaw AH; Lennon GP; Burton AR; Vignali DA. 2012. Prevention of autoimmune diabetes by ectopic pancreatic beta-cell expression of interleukin-35. Diabetes 61(6):1519-26. [PubMed: 22427377]  [MGI Ref ID J:196852]

Biedermann KA; Sun JR; Giaccia AJ; Tosto LM; Brown JM. 1991. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A 88(4):1394-7. [PubMed: 1996340]  [MGI Ref ID J:89590]

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol 191(4):1753-64. [PubMed: 23833235]  [MGI Ref ID J:205706]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Blanc L; Ciciotte SL; Gwynn B; Hildick-Smith GJ; Pierce EL; Soltis KA; Cooney JD; Paw BH; Peters LL. 2012. Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A 109(30):12099-104. [PubMed: 22773809]  [MGI Ref ID J:186485]

Blunt T; Gell D; Fox M; Taccioli GE; Lehmann AR; Jackson SP; Jeggo PA. 1996. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci U S A 93(19):10285-90. [PubMed: 8816792]  [MGI Ref ID J:35393]

Bobbala D; Chen XL; Leblanc C; Mayhue M; Stankova J; Tanaka T; Chen YG; Ilangumaran S; Ramanathan S. 2012. Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. Diabetologia 55(11):3010-20. [PubMed: 22890824]  [MGI Ref ID J:191833]

Boggiatto PM; Jie F; Ghosh M; Gibson-Corley KN; Ramer-Tait AE; Jones DE; Petersen CA. 2009. Altered dendritic cell phenotype in response to Leishmania amazonensis amastigote infection is mediated by MAP kinase, ERK. Am J Pathol 174(5):1818-26. [PubMed: 19349356]  [MGI Ref ID J:147971]

Bogue MA; Zhu C; Aguilar-Cordova E; Donehower LA; Roth DB. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev 10(5):553-65. [PubMed: 8598286]  [MGI Ref ID J:31868]

Boitano AE; Wang J; Romeo R; Bouchez LC; Parker AE; Sutton SE; Walker JR; Flaveny CA; Perdew GH; Denison MS; Schultz PG; Cooke MP. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-8. [PubMed: 20688981]  [MGI Ref ID J:167433]

Boldizsar F; Tarjanyi O; Nemeth P; Mikecz K; Glant TT. 2009. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol 21(5):511-22. [PubMed: 19254958]  [MGI Ref ID J:148186]

Bolz DD; Sundsbak RS; Ma Y; Akira S; Kirschning CJ; Zachary JF; Weis JH; Weis JJ. 2004. MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. J Immunol 173(3):2003-10. [PubMed: 15265935]  [MGI Ref ID J:92031]

Bolz DD; Sundsbak RS; Ma Y; Akira S; Weis JH; Schwan TG; Weis JJ. 2006. Dual role of MyD88 in rapid clearance of relapsing fever Borrelia spp. Infect Immun 74(12):6750-60. [PubMed: 17030581]  [MGI Ref ID J:116070]

Bonifazi P; Zelante T; D'Angelo C; De Luca A; Moretti S; Bozza S; Perruccio K; Iannitti RG; Giovannini G; Volpi C; Fallarino F; Puccetti P; Romani L. 2009. Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol 2(4):362-74. [PubMed: 19421183]  [MGI Ref ID J:193381]

Bosma GC; Custer RP; Bosma MJ. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301(5900):527-30. [PubMed: 6823332]  [MGI Ref ID J:6958]

Bosma GC; Oshinsky J; Kiefer K; Nakajima PB; Charan D; Congelton C; Radic M; Bosma MJ. 2006. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol 176(2):889-98. [PubMed: 16393973]  [MGI Ref ID J:126632]

Bosma M; Schuler W; Bosma G. 1988. The scid mouse mutant. Curr Top Microbiol Immunol 137:197-202. [PubMed: 3416632]  [MGI Ref ID J:9341]

Boyartchuk V; Rojas M; Yan BS; Jobe O; Hurt N; Dorfman DM; Higgins DE; Dietrich WF; Kramnik I. 2004. The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice. J Immunol 173(8):5112-20. [PubMed: 15470055]  [MGI Ref ID J:93705]

Braumuller H; Wieder T; Brenner E; Assmann S; Hahn M; Alkhaled M; Schilbach K; Essmann F; Kneilling M; Griessinger C; Ranta F; Ullrich S; Mocikat R; Braungart K; Mehra T; Fehrenbacher B; Berdel J; Niessner H; Meier F; van den Broek M; Haring HU; Handgretinger R; Quintanilla-Martinez L; Fend F; Pesic M; Bauer J; Zender L; Schaller M; Schulze-Osthoff K; Rocken M. 2013. T-helper-1-cell cytokines drive cancer into senescence. Nature 494(7437):361-5. [PubMed: 23376950]  [MGI Ref ID J:194546]

Bregenholt S; Claesson MH. 1998. Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur J Immunol 28(1):379-89. [PubMed: 9485217]  [MGI Ref ID J:45906]

Bregenholt S; Claesson MH. 1998. Splenic T helper cell type 1 cytokine profile and extramedullary haematopoiesis in severe combined immunodeficient (scid) mice with inflammatory bowel disease (IBD). Clin Exp Immunol 111(1):166-72. [PubMed: 9472677]  [MGI Ref ID J:45450]

Brehm MA; Racki WJ; Leif J; Burzenski L; Hosur V; Wetmore A; Gott B; Herlihy M; Ignotz R; Dunn R; Shultz LD; Greiner DL. 2012. Engraftment of human HSC in non-irradiated newborn NOD-scid IL2rgammanull mice is enhanced by transgenic expression of membrane-bound human SCF. Blood :. [PubMed: 22246028]  [MGI Ref ID J:180273]

Brem-Exner BG; Sattler C; Hutchinson JA; Koehl GE; Kronenberg K; Farkas S; Inoue S; Blank C; Knechtle SJ; Schlitt HJ; Fandrich F; Geissler EK. 2008. Macrophages driven to a novel state of activation have anti-inflammatory properties in mice. J Immunol 180(1):335-49. [PubMed: 18097035]  [MGI Ref ID J:130932]

Bridgett M; Cetkovic-Cvrlje M; O'Rourke R; Shi Y; Narayanswami S; Lambert J; Ramiya V; Baekkeskov S; Leiter EH. 1998. Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. Diabetes 47(12):1848-56. [PubMed: 9836515]  [MGI Ref ID J:100251]

Browning JL; Allaire N; Ngam-Ek A; Notidis E; Hunt J; Perrin S; Fava RA. 2005. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity 23(5):539-50. [PubMed: 16286021]  [MGI Ref ID J:113284]

Bueno C; Lopes LF; Greaves M; Menendez P. 2007. Toward development of a novel NOD/SCID-based in vivo strategy to model multiple myeloma pathogenesis. Exp Hematol 35(10):1477-8. [PubMed: 17681665]  [MGI Ref ID J:126691]

Bugl S; Wirths S; Radsak MP; Schild H; Stein P; Andre MC; Muller MR; Malenke E; Wiesner T; Marklin M; Frick JS; Handgretinger R; Rammensee HG; Kanz L; Kopp HG. 2013. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 121(5):723-33. [PubMed: 23223360]  [MGI Ref ID J:194620]

Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. [PubMed: 11152110]  [MGI Ref ID J:66571]

Buning J; Schmitz M; Repenning B; Ludwig D; Schmidt MA; Strobel S; Zimmer KP. 2005. Interferon-gamma mediates antigen trafficking to MHC class II-positive late endosomes of enterocytes. Eur J Immunol 35(3):831-42. [PubMed: 15688349]  [MGI Ref ID J:96737]

Burdeinick-Kerr R; Wind J; Griffin DE. 2007. Synergistic roles of antibody and interferon in noncytolytic clearance of Sindbis virus from different regions of the central nervous system. J Virol 81(11):5628-36. [PubMed: 17376910]  [MGI Ref ID J:153321]

Burke SD; Barrette VF; Carter AL; Gravel J; Adams MA; Croy BA. 2011. Cardiovascular adaptations of pregnancy in T and B cell-deficient mice. Biol Reprod 85(3):605-14. [PubMed: 21613629]  [MGI Ref ID J:176701]

Burr KL; Smith AG; Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene 24(26):4315-8. [PubMed: 15806156]  [MGI Ref ID J:99550]

Butler JM; Nolan DJ; Vertes EL; Varnum-Finney B; Kobayashi H; Hooper AT; Seandel M; Shido K; White IA; Kobayashi M; Witte L; May C; Shawber C; Kimura Y; Kitajewski J; Rosenwaks Z; Bernstein ID; Rafii S. 2010. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell 6(3):251-64. [PubMed: 20207228]  [MGI Ref ID J:158983]

Calderon B; Suri A; Unanue ER. 2006. In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model. Am J Pathol 169(6):2137-47. [PubMed: 17148676]  [MGI Ref ID J:116218]

Callen E; Jankovic M; Wong N; Zha S; Chen HT; Difilippantonio S; Di Virgilio M; Heidkamp G; Alt FW; Nussenzweig A; Nussenzweig M. 2009. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34(3):285-97. [PubMed: 19450527]  [MGI Ref ID J:150435]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598]  [MGI Ref ID J:123753]

Carter CR; Whitcomb JP; Campbell JA; Mukbel RM; McDowell MA. 2009. Complement receptor 3 deficiency influences lesion progression during Leishmania major infection in BALB/c mice. Infect Immun 77(12):5668-75. [PubMed: 19797068]  [MGI Ref ID J:155481]

Chang Y; Bosma GC; Bosma MJ. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity 2(6):607-16. [PubMed: 7796294]  [MGI Ref ID J:27341]

Chang Y; Bosma MJ. 1997. Effect of different Ig transgenes on B cell differentiation in scid mice. Int Immunol 9(3):373-80. [PubMed: 9088976]  [MGI Ref ID J:125479]

Chaparro RJ; Konigshofer Y; Beilhack GF; Shizuru JA; McDevitt HO; Chien YH. 2006. Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Proc Natl Acad Sci U S A 103(33):12475-80. [PubMed: 16895987]  [MGI Ref ID J:111775]

Chen AM; Zhou Y; Swenson K; Sachs DH; Sykes M; Yang YG. 2000. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation 69(12):2484-90. [PubMed: 10910267]  [MGI Ref ID J:93486]

Chen CH; Yeh YC; Wu GJ; Huang YH; Lai WF; Liu JY; Tzeng CR. 2010. Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging. Reproduction 140(1):105-12. [PubMed: 20423932]  [MGI Ref ID J:175817]

Chen D; Pacal M; Wenzel P; Knoepfler PS; Leone G; Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462(7275):925-9. [PubMed: 20016601]  [MGI Ref ID J:155800]

Chen G; Han G; Wang J; Wang R; Xu R; Shen B; Qian J; Li Y. 2009. Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta. Am J Pathol 175(3):1086-94. [PubMed: 19644014]  [MGI Ref ID J:152908]

Chen J; Chen YG; Reifsnyder PC; Schott WH; Lee CH; Osborne M; Scheuplein F; Haag F; Koch-Nolte F; Serreze DV; Leiter EH. 2006. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. J Immunol 176(8):4590-9. [PubMed: 16585549]  [MGI Ref ID J:108097]

Chen J; Gusdon AM; Piganelli J; Leiter EH; Mathews CE. 2011. mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic beta-cell. Diabetes 60(1):355-9. [PubMed: 20980458]  [MGI Ref ID J:170153]

Chen Q; Amaladoss A; Ye W; Liu M; Dummler S; Kong F; Wong LH; Loo HL; Loh E; Tan SQ; Tan TC; Chang KT; Dao M; Suresh S; Preiser PR; Chen J. 2014. Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci U S A 111(4):1479-84. [PubMed: 24474774]  [MGI Ref ID J:206650]

Chi X; Zhi L; Gelderman MP; Vostal JG. 2012. Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. PLoS One 7(9):e44829. [PubMed: 23028636]  [MGI Ref ID J:191794]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Chiaraviglio L; Duong S; Brown DA; Birtles RJ; Kirby JE. 2010. An immunocompromised murine model of chronic Bartonella infection. Am J Pathol 176(6):2753-63. [PubMed: 20395436]  [MGI Ref ID J:161161]

Chirieleison SM; Feduska JM; Schugar RC; Askew Y; Deasy BM. 2012. Human muscle-derived cell populations isolated by differential adhesion rates: phenotype and contribution to skeletal muscle regeneration in Mdx/SCID mice. Tissue Eng Part A 18(3-4):232-41. [PubMed: 21854253]  [MGI Ref ID J:181239]

Chiu IM; Heesters BA; Ghasemlou N; Von Hehn CA; Zhao F; Tran J; Wainger B; Strominger A; Muralidharan S; Horswill AR; Bubeck Wardenburg J; Hwang SW; Carroll MC; Woolf CJ. 2013. Bacteria activate sensory neurons that modulate pain and inflammation. Nature 501(7465):52-7. [PubMed: 23965627]  [MGI Ref ID J:205431]

Choi B; Chun E; Kim M; Kim SY; Kim ST; Yoon K; Lee KY; Kim SJ. 2011. Human T cell development in the liver of humanized NOD/SCID/IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139(3):321-35. [PubMed: 21429805]  [MGI Ref ID J:173961]

Chou FC; Shieh SJ; Sytwu HK. 2009. Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39(9):2403-11. [PubMed: 19670381]  [MGI Ref ID J:152168]

Chow LH. 1993. Studies of virus-induced myocardial injury in mice: value of the scid mutation on different genetic backgrounds and combined with other mutations. Lab Anim Sci 43(2):133-5. [PubMed: 8391609]  [MGI Ref ID J:12476]

Christianson SW; Greiner DL; Hesselton RA; Leif JH; Wagar EJ; Schweitzer IB; Rajan TV; Gott B; Roopenian DC; Shultz LD. 1997. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158(8):3578-86. [PubMed: 9103418]  [MGI Ref ID J:102141]

Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787]  [MGI Ref ID J:34814]

Cleveland SM; Smith S; Tripathi R; Mathias EM; Goodings C; Elliott N; Peng D; El-Rifai W; Yi D; Chen X; Li L; Mullighan C; Downing JR; Love P; Dave UP. 2013. Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia. Stem Cells 31(5):882-94. [PubMed: 23378057]  [MGI Ref ID J:196312]

Cook AJ; Oganesian L; Harumal P; Basten A; Brink R; Jolly CJ. 2003. Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions. J Immunol 171(12):6556-64. [PubMed: 14662857]  [MGI Ref ID J:117994]

Coombes JL; Siddiqui KR; Arancibia-Carcamo CV; Hall J; Sun CM; Belkaid Y; Powrie F. 2007. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757-64. [PubMed: 17620361]  [MGI Ref ID J:203901]

Coppola V; Barrick CA; Southon EA; Celeste A; Wang K; Chen B; Haddad el-B; Yin J; Nussenzweig A; Subramaniam A; Tessarollo L. 2004. Ablation of TrkA function in the immune system causes B cell abnormalities. Development 131(20):5185-95. [PubMed: 15459109]  [MGI Ref ID J:93578]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Craven AJ; Nixon AJ; Ashby MG; Ormandy CJ; Blazek K; Wilkins RJ; Pearson AJ. 2006. Prolactin delays hair regrowth in mice. J Endocrinol 191(2):415-25. [PubMed: 17088411]  [MGI Ref ID J:114701]

Crowe MJ; Doetschman T; Greenhalgh DG. 2000. Delayed wound healing in immunodeficient TGF-beta1 knockout mice J Invest Dermatol 115(1):3-11. [PubMed: 10886500]  [MGI Ref ID J:63260]

Crowley SD; Song YS; Lin EE; Griffiths R; Kim HS; Ruiz P. 2010. Lymphocyte responses exacerbate angiotensin II-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 298(4):R1089-97. [PubMed: 20147609]  [MGI Ref ID J:158609]

Culmsee C; Bondada S; Mattson MP. 2001. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res 87(2):257-62. [PubMed: 11245929]  [MGI Ref ID J:109293]

Cupedo T; Lund FE; Ngo VN; Randall TD; Jansen W; Greuter MJ; de Waal-Malefyt R; Kraal G; Cyster JG; Mebius RE. 2004. Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13. J Immunol 173(8):4889-96. [PubMed: 15470030]  [MGI Ref ID J:93711]

Custer RP; Bosma GC; Bosma MJ. 1985. Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 120(3):464-77. [PubMed: 2412448]  [MGI Ref ID J:30980]

Dann SM; Spehlmann ME; Hammond DC; Iimura M; Hase K; Choi LJ; Hanson E; Eckmann L. 2008. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol 180(10):6816-26. [PubMed: 18453602]  [MGI Ref ID J:134871]

Danska JS; Holland DP; Mariathasan S; Williams KM; Guidos CJ. 1996. Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol 16(10):5507-17. [PubMed: 8816463]  [MGI Ref ID J:35350]

Darwiche R; Chong MM; Santamaria P; Thomas HE; Kay TW. 2003. Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice. J Immunol 170(12):6292-7. [PubMed: 12794162]  [MGI Ref ID J:108698]

Das R; Bassiri H; Guan P; Wiener S; Banerjee PP; Zhong MC; Veillette A; Orange JS; Nichols KE. 2013. The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood 121(17):3386-95. [PubMed: 23430111]  [MGI Ref ID J:196692]

De Palma M; Venneri MA; Galli R; Sergi LS; Politi LS; Sampaolesi M; Naldini L. 2005. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211-26. [PubMed: 16169466]  [MGI Ref ID J:102241]

Derecki NC; Cardani AN; Yang CH; Quinnies KM; Crihfield A; Lynch KR; Kipnis J. 2010. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med 207(5):1067-80. [PubMed: 20439540]  [MGI Ref ID J:160932]

DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol 105(3):332-41. [PubMed: 12498815]  [MGI Ref ID J:94192]

Diamond RA; Ward SB; Owada-Makabe K; Wang H; Rothenberg EV. 1997. Different developmental arrest points in RAG-2 -/- and SCID thymocytes on two genetic backgrounds: developmental choices and cell death mechanisms before TCR gene rearrangement. J Immunol 158(9):4052-64. [PubMed: 9126963]  [MGI Ref ID J:39793]

Diaz-Manera J; Touvier T; Dellavalle A; Tonlorenzi R; Tedesco FS; Messina G; Meregalli M; Navarro C; Perani L; Bonfanti C; Illa I; Torrente Y; Cossu G. 2010. Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy. Cell Death Dis 1:e61. [PubMed: 21364666]  [MGI Ref ID J:186461]

Dibra D; Cutrera JJ; Li S. 2012. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol 188(8):3709-15. [PubMed: 22407920]  [MGI Ref ID J:184078]

Dodig TD; Mack KT; Cassarino DF; Clark SH. 2001. Development of the tight-skin phenotype in immune-deficient mice. Arthritis Rheum 44(3):723-7. [PubMed: 11263788]  [MGI Ref ID J:112962]

Doherty TM; Sher A. 1997. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol 158(10):4822-31. [PubMed: 9144497]  [MGI Ref ID J:40202]

Dohi T; Fujihashi K; Koga T; Etani Y; Yoshino N; Kawamura YI; McGhee JR. 2004. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am J Pathol 165(4):1257-68. [PubMed: 15466391]  [MGI Ref ID J:93676]

Dohi T; Fujihashi K; Koga T; Shirai Y; Kawamura YI; Ejima C; Kato R; Saitoh K; McGhee JR. 2003. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology 124(3):672-82. [PubMed: 12612906]  [MGI Ref ID J:82106]

Dominique V; Francis L. 1995. Interactions of the scid or beige mutations with the viable motheaten mutation. Autoimmunity 22(4):199-207. [PubMed: 8781712]  [MGI Ref ID J:33985]

Dorshkind K; Keller GM; Phillips RA; Miller RG; Bosma GC; O'Toole M; Bosma MJ. 1984. Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease. J Immunol 132(4):1804-8. [PubMed: 6607948]  [MGI Ref ID J:7343]

Dos Santos C; McDonald T; Ho YW; Liu H; Lin A; Forman SJ; Kuo YH; Bhatia R. 2013. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 122(11):1900-13. [PubMed: 23896410]  [MGI Ref ID J:202360]

Dreyer AM; Matile H; Papastogiannidis P; Kamber J; Favuzza P; Voss TS; Wittlin S; Pluschke G. 2012. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol 188(12):6225-37. [PubMed: 22593616]  [MGI Ref ID J:188965]

Dudek NL; Thomas HE; Mariana L; Sutherland RM; Allison J; Estella E; Angstetra E; Trapani JA; Santamaria P; Lew AM; Kay TW. 2006. Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways. Diabetes 55(9):2412-8. [PubMed: 16936188]  [MGI Ref ID J:116592]

Dudley ME; Sundberg JP; Roopenian DC. 1996. Frequency and histological appearance of adenomas in multiple intestinal neoplasia mice are unaffected by severe combined immunodeficiency (scid) mutation. Int J Cancer 65(2):249-53. [PubMed: 8567125]  [MGI Ref ID J:31690]

Dullin C; Missbach-Guentner J; Vogel WF; Grabbe E; Alves F. 2007. Semi-Automatic Classification of Skeletal Morphology in Genetically Altered Mice Using Flat-Panel Volume Computed Tomography. PLoS Genet 3(7):e118. [PubMed: 17658952]  [MGI Ref ID J:123719]

Eaton KA; Benson LH; Haeger J; Gray BM. 2006. Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice. Infect Immun 74(8):4673-84. [PubMed: 16861655]  [MGI Ref ID J:112403]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

Ebrahem Q; Chaurasia SS; Vasanji A; Qi JH; Klenotic PA; Cutler A; Asosingh K; Erzurum S; Anand-Apte B. 2010. Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo. Am J Pathol 176(1):496-503. [PubMed: 19948826]  [MGI Ref ID J:156380]

Economopoulos V; Noad JC; Krishnamoorthy S; Rutt BK; Foster PJ. 2011. Comparing the MRI appearance of the lymph nodes and spleen in wild-type and immuno-deficient mouse strains. PLoS One 6(11):e27508. [PubMed: 22096586]  [MGI Ref ID J:180968]

Emoto M; Mittrucker HW; Schmits R; Mak TW; Kaufmann SH. 1999. Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells. J Immunol 162(9):5094-8. [PubMed: 10227978]  [MGI Ref ID J:111009]

Engle SJ; Ormsby I; Pawlowski S; Boivin GP; Croft J; Balish E; Doetschman T. 2002. Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice. Cancer Res 62(22):6362-6. [PubMed: 12438215]  [MGI Ref ID J:80209]

Ernst PB; Erickson LD; Loo WM; Scott KG; Wiznerowicz EB; Brown CC; Torres-Velez FJ; Alam MS; Black SG; McDuffie M; Feldman SH; Wallace JL; McKnight GW; Padol IT; Hunt RH; Tung KS. 2012. Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. Am J Physiol Gastrointest Liver Physiol 302(1):G105-15. [PubMed: 21921286]  [MGI Ref ID J:183342]

Eyob H; Ekiz HA; Derose YS; Waltz SE; Williams MA; Welm AL. 2013. Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. Cancer Discov 3(7):751-60. [PubMed: 23612011]  [MGI Ref ID J:203569]

Fahlen L; Read S; Gorelik L; Hurst SD; Coffman RL; Flavell RA; Powrie F. 2005. T cells that cannot respond to TGF-{beta} escape control by CD4+CD25+ regulatory T cells. J Exp Med 201(5):737-46. [PubMed: 15753207]  [MGI Ref ID J:96624]

Faleo G; Fotino C; Bocca N; Molano RD; Zahr-Akrawi E; Molina J; Villate S; Umland O; Skyler JS; Bayer AL; Ricordi C; Pileggi A. 2012. Prevention of autoimmune diabetes and induction of beta-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes 61(7):1769-78. [PubMed: 22566533]  [MGI Ref ID J:203601]

Fang R; Ismail N; Walker DH. 2012. Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium. Am J Pathol 181(1):185-95. [PubMed: 22617213]  [MGI Ref ID J:185539]

Farini A; Meregalli M; Belicchi M; Battistelli M; Parolini D; D'Antona G; Gavina M; Ottoboni L; Constantin G; Bottinelli R; Torrente Y. 2007. T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse. J Pathol 213(2):229-38. [PubMed: 17668421]  [MGI Ref ID J:125527]

Farini A; Sitzia C; Navarro C; D'Antona G; Belicchi M; Parolini D; Del Fraro G; Razini P; Bottinelli R; Meregalli M; Torrente Y. 2012. Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model. Exp Cell Res 318(10):1160-74. [PubMed: 22465227]  [MGI Ref ID J:186460]

Fernandez NC; Lozier A; Flament C; Ricciardi-Castagnoli P; Bellet D; Suter M; Perricaudet M; Tursz T; Maraskovsky E; Zitvogel L. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat Med 5(4):405-11. [PubMed: 10202929]  [MGI Ref ID J:54135]

Fiorucci S; Mencarelli A; Palazzetti B; Sprague AG; Distrutti E; Morelli A; Novobrantseva TI; Cirino G; Koteliansky VE; de Fougerolles AR. 2002. Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity 17(6):769-80. [PubMed: 12479823]  [MGI Ref ID J:113581]

Flanagan K; Modrusan Z; Cornelius J; Chavali A; Kasman I; Komuves L; Mo L; Diehl L. 2008. Intestinal Epithelial Cell Up-Regulation of LY6 Molecules during Colitis Results in Enhanced Chemokine Secretion. J Immunol 180(6):3874-81. [PubMed: 18322195]  [MGI Ref ID J:133031]

Flesken-Nikitin A; Hwang CI; Cheng CY; Michurina TV; Enikolopov G; Nikitin AY. 2013. Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Nature 495(7440):241-5. [PubMed: 23467088]  [MGI Ref ID J:194916]

Fogler WE; Volker K; Watanabe M; Wigginton JM; Roessler P; Brunda MJ; Ortaldo JR; Wiltrout RH. 1998. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J Immunol 161(11):6014-21. [PubMed: 9834083]  [MGI Ref ID J:115033]

Forbes JM; Soderlund J; Yap FY; Knip M; Andrikopoulos S; Ilonen J; Simell O; Veijola R; Sourris KC; Coughlan MT; Forsblom C; Slattery R; Grey ST; Wessman M; Yamamoto H; Bierhaus A; Cooper ME; Groop PH. 2011. Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia :. [PubMed: 21298413]  [MGI Ref ID J:169600]

Ford ML; Evavold BD. 2006. Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43. Cell Immunol 240(1):53-61. [PubMed: 16890924]  [MGI Ref ID J:112761]

Fortner KA; Lees RK; Macdonald HR; Budd RC. 2011. Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts. Int Immunol 23(2):75-88. [PubMed: 21266499]  [MGI Ref ID J:168554]

Fournier B; Murray B; Gutzwiller S; Marcaletti S; Marcellin D; Bergling S; Brachat S; Persohn E; Pierrel E; Bombard F; Hatakeyama S; Trendelenburg AU; Morvan F; Richardson B; Glass DJ; Lach-Trifilieff E; Feige JN. 2012. Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol 32(14):2871-9. [PubMed: 22586266]  [MGI Ref ID J:186659]

Franco S; Murphy MM; Li G; Borjeson T; Boboila C; Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205(3):557-64. [PubMed: 18316419]  [MGI Ref ID J:133132]

Frese M; Lee E; Larena M; Lim PS; Rao S; Matthaei KI; Khromykh A; Ramshaw I; Lobigs M. 2014. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol 88(4):2056-70. [PubMed: 24307589]  [MGI Ref ID J:205265]

Friswell MK; Gika H; Stratford IJ; Theodoridis G; Telfer B; Wilson ID; McBain AJ. 2010. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS One 5(1):e8584. [PubMed: 20052418]  [MGI Ref ID J:157249]

Fukunaga-Kalabis M; Martinez G; Nguyen TK; Kim D; Santiago-Walker A; Roesch A; Herlyn M. 2010. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene 29(46):6115-24. [PubMed: 20729912]  [MGI Ref ID J:166563]

Fulop GM; Phillips RA. 1986. Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients. J Immunol 136(12):4438-43. [PubMed: 3519770]  [MGI Ref ID J:8299]

Fyfe AI; Qiao JH; Lusis AJ. 1994. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest 94(6):2516-20. [PubMed: 7989611]  [MGI Ref ID J:22138]

Gallo-Hendrikx E; Percy D; Copps J; McKeown B; Quinton M; McMillan I; Croy BA; Wildeman AG. 1999. Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors. APMIS 107(2):245-56. [PubMed: 10225324]  [MGI Ref ID J:54114]

Ganley L; Babu S; Rajan TV. 2001. Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice. Exp Parasitol 98(1):35-43. [PubMed: 11426950]  [MGI Ref ID J:102684]

Garcia-Barros M; Thin TH; Maj J; Cordon-Cardo C; Haimovitz-Friedman A; Fuks Z; Kolesnick R. 2010. Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited. Cancer Res 70(20):8179-86. [PubMed: 20924105]  [MGI Ref ID J:165564]

Garcia-Rivera MF; Colvin-Wanshura LE; Nelson MS; Nan Z; Khan SA; Rogers TB; Maitra I; Low WC; Gupta P. 2007. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Brain Res Bull 74(6):429-38. [PubMed: 17920451]  [MGI Ref ID J:139626]

Gawronska-Kozak B; Bogacki M; Rim JS; Monroe WT; Manuel JA. 2006. Scarless skin repair in immunodeficient mice. Wound Repair Regen 14(3):265-76. [PubMed: 16808805]  [MGI Ref ID J:135709]

Gelman AE; LaRosa DF; Zhang J; Walsh PT; Choi Y; Sunyer JO; Turka LA. 2006. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 25(5):783-93. [PubMed: 17055754]  [MGI Ref ID J:116106]

Gerling IC; Friedman H; Greiner DL; Shultz LD; Leiter EH. 1994. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes 43(3):433-40. [PubMed: 8314017]  [MGI Ref ID J:16998]

Gesina E; Blondeau B; Milet A; Le Nin I; Duchene B; Czernichow P; Scharfmann R; Tronche F; Breant B. 2006. Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Diabetologia 49(12):2939-47. [PubMed: 17001468]  [MGI Ref ID J:147261]

Gittens JE; Barr KJ; Vanderhyden BC; Kidder GM. 2005. Interplay between paracrine signaling and gap junctional communication in ovarian follicles. J Cell Sci 118(Pt 1):113-22. [PubMed: 15585573]  [MGI Ref ID J:94692]

Gladdy RA; Nutter LM; Kunath T; Danska JS; Guidos CJ. 2006. p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res 4(5):311-8. [PubMed: 16687486]  [MGI Ref ID J:108789]

Gladdy RA; Taylor MD; Williams CJ; Grandal I; Karaskova J; Squire JA; Rutka JT; Guidos CJ; Danska JS. 2003. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 3(1):37-50. [PubMed: 12559174]  [MGI Ref ID J:81538]

Glimm H; Eisterer W; Lee K; Cashman J; Holyoake TL; Nicolini F; Shultz LD; von Kalle C; Eaves CJ. 2001. Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest 107(2):199-206. [PubMed: 11160136]  [MGI Ref ID J:66974]

Goldstein AS; Huang J; Guo C; Garraway IP; Witte ON. 2010. Identification of a cell of origin for human prostate cancer. Science 329(5991):568-71. [PubMed: 20671189]  [MGI Ref ID J:162606]

Gorantla S; Makarov E; Finke-Dwyer J; Gebhart CL; Domm W; Dewhurst S; Gendelman HE; Poluektova LY. 2010. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J Immunol 184(12):7082-91. [PubMed: 20495069]  [MGI Ref ID J:161304]

Graff RJ. 1970. Polymorphism of histocompatibility genes in the mouse. Transplant Proc 2(1):15-23. [PubMed: 4107291]  [MGI Ref ID J:5237]

Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754]  [MGI Ref ID J:93553]

Gray CA; Lawrence RA. 2002. A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 32(4):1114-20. [PubMed: 11920579]  [MGI Ref ID J:115364]

Green-Mitchell SM; Tersey SA; Cole BK; Ma K; Kuhn NS; Cunningham TD; Maybee NA; Chakrabarti SK; McDuffie M; Taylor-Fishwick DA; Mirmira RG; Nadler JL; Morris MA. 2013. Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development. PLoS One 8(2):e56763. [PubMed: 23437231]  [MGI Ref ID J:197192]

Grenningloh R; Kang BY; Ho IC. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med 201(4):615-26. [PubMed: 15728239]  [MGI Ref ID J:96627]

Guay HM; Andreyeva TA; Garcea RL; Welsh RM; Szomolanyi-Tsuda E. 2007. MyD88 is required for the formation of long-term humoral immunity to virus infection. J Immunol 178(8):5124-31. [PubMed: 17404295]  [MGI Ref ID J:145278]

Guay HM; Panarey L; Reed AJ; Caton AJ. 2004. Specificity-based negative selection of autoreactive B cells during memory formation. J Immunol 173(9):5485-94. [PubMed: 15494496]  [MGI Ref ID J:93744]

Guidos CJ; Williams CJ; Grandal I; Knowles G; Huang MT; Danska JS. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 10(16):2038-54. [PubMed: 8769647]  [MGI Ref ID J:102044]

Gurley KE; Kemp CJ. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr Biol 11(3):191-4. [PubMed: 11231155]  [MGI Ref ID J:67533]

Gurley KE; Vo K; Kemp CJ. 1998. DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice. Cancer Res 58(14):3111-5. [PubMed: 9679979]  [MGI Ref ID J:49372]

Haks MC; Belkowski SM; Ciofani M; Rhodes M; Lefebvre JM; Trop S; Hugo P; Zuniga-Pflucker JC; Wiest DL. 2003. Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells. J Immunol 170(6):2853-61. [PubMed: 12626535]  [MGI Ref ID J:126301]

Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101. [PubMed: 10435582]  [MGI Ref ID J:110456]

Halim TY; Maclaren A; Romanish MT; Gold MJ; McNagny KM; Takei F. 2012. Retinoic-Acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37(3):463-74. [PubMed: 22981535]  [MGI Ref ID J:187662]

Halin C; Tobler NE; Vigl B; Brown LF; Detmar M. 2007. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 110(9):3158-67. [PubMed: 17625067]  [MGI Ref ID J:148904]

Haller BL; Barkon ML; Vogler GP; Virgin HW 4th. 1995. Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes. J Virol 69(1):357-64. [PubMed: 7983730]  [MGI Ref ID J:21933]

Hande P; Slijepcevic P; Silver A; Bouffler S; van Buul P; Bryant P ; Lansdorp P. 1999. Elongated telomeres in scid mice. Genomics 56(2):221-3. [PubMed: 10051409]  [MGI Ref ID J:53579]

Hanks BA; Holtzhausen A; Evans KS; Jamieson R; Gimpel P; Campbell OM; Hector-Greene M; Sun L; Tewari A; George A; Starr M; Nixon A; Augustine C; Beasley G; Tyler DS; Osada T; Morse MA; Ling L; Lyerly HK; Blobe GC. 2013. Type III TGF-beta receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest 123(9):3925-40. [PubMed: 23925295]  [MGI Ref ID J:201617]

Harkness RE; Guimond MJ; McBey BA; Klein MH; Percy DH; Croy BA. 1993. Branhamella catarrhalis pathogenesis in SCID and SCID/beige mice. Brief report. APMIS 101(10):805-10. [PubMed: 8267959]  [MGI Ref ID J:16050]

Harris WJ; Huang X; Lynch JT; Spencer GJ; Hitchin JR; Li Y; Ciceri F; Blaser JG; Greystoke BF; Jordan AM; Miller CJ; Ogilvie DJ; Somervaille TC. 2012. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 21(4):473-87. [PubMed: 22464800]  [MGI Ref ID J:189339]

Hasegawa M; Kawai K; Mitsui T; Taniguchi K; Monnai M; Wakui M; Ito M; Suematsu M; Peltz G; Nakamura M; Suemizu H. 2011. The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem Biophys Res Commun 405(3):405-10. [PubMed: 21238430]  [MGI Ref ID J:170638]

Hastey CJ; Elsner RA; Barthold SW; Baumgarth N. 2012. Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. J Immunol 188(11):5612-22. [PubMed: 22547698]  [MGI Ref ID J:188726]

Hayashi Y; Haneji N; Hamano H; Yanagi K. 1994. Transfer of Sjogren's syndrome-like autoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 24(11):2826-31. [PubMed: 7957574]  [MGI Ref ID J:21965]

Hayward AR; Chmura K; Cosyns M. 2000. Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice. J Infect Dis 182(3):1001-4. [PubMed: 10950807]  [MGI Ref ID J:125986]

He J; Haskins K. 2008. Pathogenicity of T helper 2 T-cell clones from T-cell receptor transgenic non-obese diabetic mice is determined by tumour necrosis factor-alpha. Immunology 123(1):108-17. [PubMed: 17983440]  [MGI Ref ID J:134900]

He Q; Morillon YM 2nd; Spidale NA; Kroger CJ; Liu B; Sartor RB; Wang B; Tisch R. 2013. Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol 191(12):5858-66. [PubMed: 24198282]  [MGI Ref ID J:207147]

Heaney NB; Pellicano F; Zhang B; Crawford L; Chu S; Kazmi SM; Allan EK; Jorgensen HG; Irvine AE; Bhatia R; Holyoake TL. 2010. Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. Blood 115(11):2241-50. [PubMed: 20068223]  [MGI Ref ID J:162612]

Heine D; Passmore HC; Patel V; Shultz LD; Ward-Bailey P; Cook SA; Davisson MT. 1996. Effect of the mouse scid mutation on meiotic recombination. Mamm Genome 7(7):497-500. [PubMed: 8672126]  [MGI Ref ID J:34473]

Hernandez-Novoa B; Bishop L; Logun C; Munson PJ; Elnekave E; Rangel ZG; Barb J; Danner RL; Kovacs JA. 2008. Immune responses to Pneumocystis murina are robust in healthy mice but largely absent in CD40 ligand-deficient mice. J Leukoc Biol 84(2):420-30. [PubMed: 18467653]  [MGI Ref ID J:138448]

Hertz CJ; Filutowicz H; Mansfield JM. 1998. Resistance to the African trypanosomes is IFN-gamma dependent. J Immunol 161(12):6775-83. [PubMed: 9862708]  [MGI Ref ID J:115095]

Hesselton RM; Greiner DL; Mordes JP; Rajan TV; Sullivan JL; Shultz LD. 1995. High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice. J Infect Dis 172(4):974-82. [PubMed: 7561218]  [MGI Ref ID J:109911]

Hettmer S; Liu J; Miller CM; Lindsay MC; Sparks CA; Guertin DA; Bronson RT; Langenau DM; Wagers AJ. 2011. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proc Natl Acad Sci U S A 108(50):20002-7. [PubMed: 22135462]  [MGI Ref ID J:180528]

Hilbert DM; Anderson AO; Holmes KL; Rudikoff S. 1994. Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues. Transplantation 58(4):466-75. [PubMed: 8073516]  [MGI Ref ID J:19983]

Hioki K; Kuramochi T; Endoh S; Terada E; Ueyama Y; Ito M. 2001. Lack of B cell leakiness in BALB/cA-nu, scid double mutant mice. Exp Anim 50(1):67-72. [PubMed: 11326425]  [MGI Ref ID J:68089]

Hirai H; Verma M; Watanabe S; Tastad C; Asakura Y; Asakura A. 2010. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol 191(2):347-65. [PubMed: 20956382]  [MGI Ref ID J:165481]

Hiramatsu H; Nishikomori R; Heike T; Ito M; Kobayashi K; Katamura K; Nakahata T. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80. [PubMed: 12689924]  [MGI Ref ID J:163372]

Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. [PubMed: 12406886]  [MGI Ref ID J:109848]

Hoggatt J; Singh P; Sampath J; Pelus LM. 2009. Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation. Blood 113(22):5444-55. [PubMed: 19324903]  [MGI Ref ID J:148898]

Holm TM; Jackson-Grusby L; Brambrink T; Yamada Y; Rideout WM 3rd; Jaenisch R. 2005. Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer Cell 8(4):275-85. [PubMed: 16226703]  [MGI Ref ID J:104860]

Holopainen T; Saharinen P; D'Amico G; Lampinen A; Eklund L; Sormunen R; Anisimov A; Zarkada G; Lohela M; Helotera H; Tammela T; Benjamin LE; Yla-Herttuala S; Leow CC; Koh GY; Alitalo K. 2012. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104(6):461-75. [PubMed: 22343031]  [MGI Ref ID J:184937]

Holt N; Wang J; Kim K; Friedman G; Wang X; Taupin V; Crooks GM; Kohn DB; Gregory PD; Holmes MC; Cannon PM. 2010. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28(8):839-47. [PubMed: 20601939]  [MGI Ref ID J:162607]

Hontecillas R; Bassaganya-Riera J. 2007. Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis. J Immunol 178(5):2940-9. [PubMed: 17312139]  [MGI Ref ID J:144105]

Horai R; Nakajima A; Habiro K; Kotani M; Nakae S; Matsuki T; Nambu A; Saijo S; Kotaki H; Sudo K; Okahara A; Tanioka H; Ikuse T; Ishii N; Schwartzberg PL; Abe R; Iwakura Y. 2004. TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11):1603-11. [PubMed: 15578092]  [MGI Ref ID J:94429]

Hoshino T; Winkler-Pickett RT; Mason AT; Ortaldo JR; Young HA. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma. J Immunol 162(1):51-9. [PubMed: 9886369]  [MGI Ref ID J:112424]

Houghtaling S; Newell A; Akkari Y; Taniguchi T; Olson S; Grompe M. 2005. Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet 14(20):3027-33. [PubMed: 16135554]  [MGI Ref ID J:102754]

Hsu DM; Agarwal S; Benham A; Coarfa C; Trahan DN; Chen Z; Stowers PN; Courtney AN; Lakoma A; Barbieri E; Metelitsa LS; Gunaratne P; Kim ES; Shohet JM. 2013. G-CSF Receptor Positive Neuroblastoma Subpopulations Are Enriched in Chemotherapy-Resistant or Relapsed Tumors and Are Highly Tumorigenic. Cancer Res 73(13):4134-46. [PubMed: 23687340]  [MGI Ref ID J:199119]

Hu Z; Van Rooijen N; Yang YG. 2011. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 118(22):5938-46. [PubMed: 21926352]  [MGI Ref ID J:178783]

Hua C; Chang B; Ma B-L; Li Y; Wang G. 1992. Reduction of lymphokine-activated killer cell activity by the introduction of the beige gene into SCID mice ILAR News 34(1-2):S15-S16.  [MGI Ref ID J:2627]

Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. [PubMed: 22753496]  [MGI Ref ID J:186492]

Hubner MP; Shi Y; Torrero MN; Mueller E; Larson D; Soloviova K; Gondorf F; Hoerauf A; Killoran KE; Stocker JT; Davies SJ; Tarbell KV; Mitre E. 2012. Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-beta. J Immunol 188(2):559-68. [PubMed: 22174447]  [MGI Ref ID J:180789]

Hugues S; Mougneau E; Ferlin W; Jeske D; Hofman P; Homann D; Beaudoin L; Schrike C; Von Herrath M; Lehuen A; Glaichenhaus N. 2002. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity 16(2):169-81. [PubMed: 11869679]  [MGI Ref ID J:132052]

Hull ML; Johan MZ; Hodge WL; Robertson SA; Ingman WV. 2012. Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis. Am J Pathol 180(3):880-7. [PubMed: 22210480]  [MGI Ref ID J:181959]

Hunter CA; Ellis-Neyes LA; Slifer T; Kanaly S; Grunig G; Fort M; Rennick D; Araujo FG. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol 158(7):3311-6. [PubMed: 9120288]  [MGI Ref ID J:110835]

Ichimura Y; Waguri S; Sou YS; Kageyama S; Hasegawa J; Ishimura R; Saito T; Yang Y; Kouno T; Fukutomi T; Hoshii T; Hirao A; Takagi K; Mizushima T; Motohashi H; Lee MS; Yoshimori T; Tanaka K; Yamamoto M; Komatsu M. 2013. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51(5):618-31. [PubMed: 24011591]  [MGI Ref ID J:203811]

Ingman WV; Robertson SA. 2008. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79(4):711-7. [PubMed: 18614704]  [MGI Ref ID J:140882]

Ingman WV; Robertson SA. 2007. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 148(8):4032-43. [PubMed: 17478551]  [MGI Ref ID J:129629]

Ingman WV; Robker RL; Woittiez K; Robertson SA. 2006. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology 147(2):835-45. [PubMed: 16269452]  [MGI Ref ID J:129446]

Ippolito GC; Hoi KH; Reddy ST; Carroll SM; Ge X; Rogosch T; Zemlin M; Shultz LD; Ellington AD; Vandenberg CL; Georgiou G. 2012. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 7(4):e35497. [PubMed: 22558161]  [MGI Ref ID J:187283]

Ishii T; Zhao Y; Sozer S; Shi J; Zhang W; Hoffman R; Xu M. 2007. Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice. Exp Hematol 35(11):1633-40. [PubMed: 17764815]  [MGI Ref ID J:132540]

Ishii-Ohba H; Kobayashi S; Nishimura M; Shimada Y; Tsuji H; Sado T; Ogiu T. 2007. Existence of a threshold-like dose for gamma-ray induction of thymic lymphomas and no susceptibility to radiation-induced solid tumors in SCID mice. Mutat Res 619(1-2):124-33. [PubMed: 17397880]  [MGI Ref ID J:120953]

Ishikawa F; Yasukawa M; Lyons B; Yoshida S; Miyamoto T; Yoshimoto G; Watanabe T; Akashi K; Shultz LD; Harada M. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106(5):1565-73. [PubMed: 15920010]  [MGI Ref ID J:142411]

Ito M; Hiramatsu H; Kobayashi K; Suzue K; Kawahata M; Hioki K; Ueyama Y; Koyanagi Y; Sugamura K; Tsuji K; Heike T; Nakahata T. 2002. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82. [PubMed: 12384415]  [MGI Ref ID J:163373]

Ito R; Katano I; Ida-Tanaka M; Kamisako T; Kawai K; Suemizu H; Aiso S; Ito M. 2012. Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rgammanull mice is attributed to a lack of CD11c+B220+CD122+ cells. J Immunol 189(9):4313-20. [PubMed: 23018460]  [MGI Ref ID J:190612]

Ito R; Negishi N; Irie N; Matsuo K; Suzuki D; Katano I; Hayakawa E; Kawai K; Kamisako T; Eto T; Ogura T; Hozumi K; Ando K; Aiso S; Tamaoki N; Habu S; Ito M. 2012. Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. Exp Hematol 40(11):953-963.e3. [PubMed: 22771497]  [MGI Ref ID J:203591]

Ito R; Takahashi T; Katano I; Kawai K; Kamisako T; Ogura T; Ida-Tanaka M; Suemizu H; Nunomura S; Ra C; Mori A; Aiso S; Ito M. 2013. Establishment of a human allergy model using human IL-3/GM-CSF-transgenic NOG mice. J Immunol 191(6):2890-9. [PubMed: 23956433]  [MGI Ref ID J:205873]

Ito T; Seyama T; Kyoizumi S; Teraoka S; Iwamoto KS; Mizuno T; Tsuyama N; Asahara T; Dohi K; Akiyama M. 1995. The usefulness of severe combined immunodeficiency (SCID) mice to study human carcinogenesis. Cancer Lett 88(1):113-7. [PubMed: 7850767]  [MGI Ref ID J:23712]

Iwai H; Abe M; Hirose S; Tsushima F; Tezuka K; Akiba H; Yagita H; Okumura K; Kohsaka H; Miyasaka N; Azuma M. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171(6):2848-54. [PubMed: 12960306]  [MGI Ref ID J:120381]

Jaakkola I; Jalkanen S; Hanninen A. 2003. Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice. Eur J Immunol 33(12):3255-64. [PubMed: 14635033]  [MGI Ref ID J:87142]

Jaeschke A; Rincon M; Doran B; Reilly J; Neuberg D; Greiner DL; Shultz LD; Rossini AA; Flavell RA; Davis RJ. 2005. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 102(19):6931-5. [PubMed: 15867147]  [MGI Ref ID J:99056]

Jaiswal S; Pearson T; Friberg H; Shultz LD; Greiner DL; Rothman AL; Mathew A. 2009. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One 4(10):e7251. [PubMed: 19802382]  [MGI Ref ID J:154110]

Janes MR; Limon JJ; So L; Chen J; Lim RJ; Chavez MA; Vu C; Lilly MB; Mallya S; Ong ST; Konopleva M; Martin MB; Ren P; Liu Y; Rommel C; Fruman DA. 2010. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med 16(2):205-13. [PubMed: 20072130]  [MGI Ref ID J:162611]

Jimenez de Bagues MP; de Martino A; Quintana JF; Alcaraz A; Pardo J. 2011. Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice. Infect Immun 79(10):3934-9. [PubMed: 21825066]  [MGI Ref ID J:175995]

Jones-Carson J; Vazquez-Torres A; Balish E. 1995. Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis 171(6):1664-7. [PubMed: 7769315]  [MGI Ref ID J:25930]

Juelke K; Killig M; Luetke-Eversloh M; Parente E; Gruen J; Morandi B; Ferlazzo G; Thiel A; Schmitt-Knosalla I; Romagnani C. 2010. CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells. Blood 116(8):1299-307. [PubMed: 20505160]  [MGI Ref ID J:163485]

Jun HS; Santamaria P; Lim HW; Zhang ML; Yoon JW. 1999. Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. Diabetes 48(1):34-42. [PubMed: 9892220]  [MGI Ref ID J:108751]

Kagari T; Doi H; Shimozato T. 2002. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol 169(3):1459-66. [PubMed: 12133972]  [MGI Ref ID J:120707]

Kahiri CN; Khalil MW; Tekpetey F; Kidder GM. 2006. Leydig cell function in mice lacking connexin43. Reproduction 132(4):607-616. [PubMed: 17008472]  [MGI Ref ID J:112888]

Kalaany NY; Sabatini DM. 2009. Tumours with PI3K activation are resistant to dietary restriction. Nature 458(7239):725-31. [PubMed: 19279572]  [MGI Ref ID J:147281]

Kariya R; Taura M; Suzu S; Kai H; Katano H; Okada S. 2014. HIV protease inhibitor Lopinavir induces apoptosis of primary effusion lymphoma cells via suppression of NF-kappaB pathway. Cancer Lett 342(1):52-9. [PubMed: 24012878]  [MGI Ref ID J:204517]

Katakura K; Lee J; Rachmilewitz D; Li G; Eckmann L; Raz E. 2005. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115(3):695-702. [PubMed: 15765149]  [MGI Ref ID J:110027]

Katakura T; Yoshida T; Kobayashi M; Herndon DN; Suzuki F. 2005. Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries. Clin Exp Immunol 142(3):419-25. [PubMed: 16297152]  [MGI Ref ID J:107603]

Kawaguchi-Miyashita M; Shimada S; Kurosu H; Kato-Nagaoka N; Matsuoka Y; Ohwaki M; Ishikawa H; Nanno M. 2001. An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice. Eur J Immunol 31(4):980-8. [PubMed: 11298322]  [MGI Ref ID J:68810]

Kawahara M; Pandolfi A; Bartholdy B; Barreyro L; Will B; Roth M; Okoye-Okafor UC; Todorova TI; Figueroa ME; Melnick A; Mitsiades CS; Steidl U. 2012. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. Cancer Cell 22(2):194-208. [PubMed: 22897850]  [MGI Ref ID J:191823]

Kayama H; Ueda Y; Sawa Y; Jeon SG; Ma JS; Okumura R; Kubo A; Ishii M; Okazaki T; Murakami M; Yamamoto M; Yagita H; Takeda K. 2012. Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis. Proc Natl Acad Sci U S A 109(13):5010-5. [PubMed: 22403066]  [MGI Ref ID J:182225]

Kazerounian S; Gerald D; Huang M; Chin YR; Udayakumar D; Zheng N; O'Donnell RK; Perruzzi C; Mangiante L; Pourat J; Phung TL; Bravo-Nuevo A; Shechter S; McNamara S; Duhadaway JB; Kocher ON; Brown LF; Toker A; Prendergast GC; Benjamin LE. 2013. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 73(1):50-61. [PubMed: 23135917]  [MGI Ref ID J:194113]

Kelly MN; Zheng M; Ruan S; Kolls J; D'Souza A; Shellito JE. 2013. Memory CD4+ T Cells Are Required for Optimal NK Cell Effector Functions against the Opportunistic Fungal Pathogen Pneumocystis murina. J Immunol 190(1):285-95. [PubMed: 23203926]  [MGI Ref ID J:190830]

Kemp CJ; Vo K; Gurley KE. 1999. Resistance to skin tumorigenesis in DNAPK-deficient SCID mice is not due to immunodeficiency but results from hypersensitivity to TPA-induced apoptosis. Carcinogenesis 20(11):2051-6. [PubMed: 10545405]  [MGI Ref ID J:58425]

Khaled AR; Li WQ; Huang J; Fry TJ; Khaled AS; Mackall CL; Muegge K; Young HA; Durum SK. 2002. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 17(5):561-73. [PubMed: 12433363]  [MGI Ref ID J:93139]

Kharbanda S; Pandey P; Jin S; Inoue S; Bharti A; Yuan ZM; Weichselbaum R; Weaver D; Kufe D. 1997. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386(6626):732-5. [PubMed: 9109492]  [MGI Ref ID J:116399]

Kiaris H; Chatzistamou I; Trimis G; Frangou-Plemmenou M; Pafiti-Kondi A; Kalofoutis A. 2005. Evidence for nonautonomous effect of p53 tumor suppressor in carcinogenesis. Cancer Res 65(5):1627-30. [PubMed: 15753354]  [MGI Ref ID J:97031]

Kiefer K; Nakajima PB; Oshinsky J; Seeholzer SH; Radic M; Bosma GC; Bosma MJ. 2008. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol 180(9):6094-106. [PubMed: 18424731]  [MGI Ref ID J:160356]

Kiefer K; Oshinsky J; Kim J; Nakajima PB; Bosma GC; Bosma MJ. 2007. The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A 104(8):2843-8. [PubMed: 17296939]  [MGI Ref ID J:125895]

Kim KD; Srikanth S; Yee MK; Mock DC; Lawson GW; Gwack Y. 2011. ORAI1 deficiency impairs activated T cell death and enhances T cell survival. J Immunol 187(7):3620-30. [PubMed: 21873530]  [MGI Ref ID J:179333]

Kim S; Dubrovska A; Salamone RJ; Walker JR; Grandinetti KB; Bonamy GM; Orth AP; Elliott J; Porta DG; Garcia-Echeverria C; Reddy VA. 2013. FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells. PLoS One 8(1):e51671. [PubMed: 23300950]  [MGI Ref ID J:195822]

Kitamura K; Nakamoto Y; Kaneko S; Mukaida N. 2004. Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis. J Leukoc Biol 76(6):1111-7. [PubMed: 15339938]  [MGI Ref ID J:94173]

Kitaura H; Zhou P; Kim HJ; Novack DV; Ross FP; Teitelbaum SL. 2005. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 115(12):3418-27. [PubMed: 16294221]  [MGI Ref ID J:104533]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Klug F; Prakash H; Huber PE; Seibel T; Bender N; Halama N; Pfirschke C; Voss RH; Timke C; Umansky L; Klapproth K; Schakel K; Garbi N; Jager D; Weitz J; Schmitz-Winnenthal H; Hammerling GJ; Beckhove P. 2013. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 24(5):589-602. [PubMed: 24209604]  [MGI Ref ID J:206743]

Kobayashi M; Nakamura K; Cornforth M; Suzuki F. 2012. Role of M2b macrophages in the acceleration of bacterial translocation and subsequent sepsis in mice exposed to whole body [137Cs] gamma-irradiation. J Immunol 189(1):296-303. [PubMed: 22664870]  [MGI Ref ID J:188934]

Kodama T; Hikita H; Kawaguchi T; Saito Y; Tanaka S; Shigekawa M; Shimizu S; Li W; Miyagi T; Kanto T; Hiramatsu N; Tatsumi T; Takehara T. 2013. The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver. J Biol Chem 288(42):30009-18. [PubMed: 23986435]  [MGI Ref ID J:203931]

Kometani K; Aoki M; Kawamata S; Shinozuka Y; Era T; Taniwaki M; Hattori M; Minato N. 2006. Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model. Cancer Res 66(20):9967-76. [PubMed: 17047059]  [MGI Ref ID J:114993]

Kong L; Robinson CP; Peck AB; Vela-Roch N; Sakata KM; Dang H; Talal N; Humphreys-Beher MG. 1998. Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice. Clin Exp Rheumatol 16(6):675-81. [PubMed: 9844759]  [MGI Ref ID J:53650]

Kumar P; Ban HS; Kim SS; Wu H; Pearson T; Greiner DL; Laouar A; Yao J; Haridas V; Habiro K; Yang YG; Jeong JH; Lee KY; Kim YH; Kim SW; Peipp M; Fey GH; Manjunath N; Shultz LD; Lee SK; Shankar P. 2008. T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell 134(4):577-86. [PubMed: 18691745]  [MGI Ref ID J:142409]

Kunisawa J; Gohda M; Kurashima Y; Ishikawa I; Higuchi M; Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells. Blood 111(9):4646-52. [PubMed: 18292290]  [MGI Ref ID J:134340]

Kupfer TM; Crawford ML; Pham K; Gill RG. 2005. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 175(4):2309-16. [PubMed: 16081800]  [MGI Ref ID J:107508]

Kurkjian C; Hollifield M; Lines JL; Rogosky A; Empey KM; Qureshi M; Brown SA; Garvy BA. 2012. Alveolar Macrophages in Neonatal Mice Are Inherently Unresponsive to Pneumocystis murina Infection. Infect Immun 80(8):2835-46. [PubMed: 22665378]  [MGI Ref ID J:186637]

Kwun J; Hu H; Schadde E; Roenneburg D; Sullivan KA; DeMartino J; Burlingham WJ; Knechtle SJ. 2007. Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. J Immunol 179(12):8016-25. [PubMed: 18056341]  [MGI Ref ID J:155042]

Larcher F; Del Rio M; Serrano F; Segovia JC; Ramirez A; Meana A; Page A; Abad JL; Gonzalez MA; Bueren J; Bernad A; Jorcano JL. 2001. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J 15(9):1529-38. [PubMed: 11427484]  [MGI Ref ID J:115148]

Lazarus JJ; Meadows MJ; Lintner RE; Wooten RM. 2006. IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses. J Immunol 177(10):7076-85. [PubMed: 17082624]  [MGI Ref ID J:140484]

Lee HM; Wysoczynski M; Liu R; Shin DM; Kucia M; Botto M; Ratajczak J; Ratajczak MZ. 2010. Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes. Leukemia 24(3):573-82. [PubMed: 20033053]  [MGI Ref ID J:158026]

Lee SM; Yang H; Tartar DM; Gao B; Luo X; Ye SQ; Zaghouani H; Fang D. 2011. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia :. [PubMed: 21340626]  [MGI Ref ID J:169586]

Lefevre S; Knedla A; Tennie C; Kampmann A; Wunrau C; Dinser R; Korb A; Schnaker EM; Tarner IH; Robbins PD; Evans CH; Sturz H; Steinmeyer J; Gay S; Scholmerich J; Pap T; Muller-Ladner U; Neumann E. 2009. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 15(12):1414-20. [PubMed: 19898488]  [MGI Ref ID J:155763]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Leung J; Suh WK. 2013. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol 190(12):6651-61. [PubMed: 23686485]  [MGI Ref ID J:204842]

Li B; Sharpe EE; Maupin AB; Teleron AA; Pyle AL; Carmeliet P; Young PP. 2006. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J 20(9):1495-7. [PubMed: 16754748]  [MGI Ref ID J:111344]

Li E; Zhou P; Singer SM. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J Immunol 176(1):516-21. [PubMed: 16365445]  [MGI Ref ID J:126256]

Li G; Zhang L; Chen E; Wang J; Jiang X; Chen JH; Wickman G; Amundson K; Bergqvist S; Zobel J; Buckman D; Baxi SM; Bender SL; Casperson GF; Hu-Lowe DD. 2010. Dual functional monoclonal antibody PF-04605412 targets integrin alpha5beta1 and elicits potent antibody-dependent cellular cytotoxicity. Cancer Res 70(24):10243-54. [PubMed: 21159645]  [MGI Ref ID J:167600]

Li SW; Koya V; Li Y; Donelan W; Lin P; Reeves WH; Yang LJ. 2010. Pancreatic duodenal homeobox 1 protein is a novel beta-cell-specific autoantigen for type I diabetes. Lab Invest 90(1):31-9. [PubMed: 19901909]  [MGI Ref ID J:156607]

Li T; Ramirez K; Palacios R. 1996. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7(1):107-14. [PubMed: 8788039]  [MGI Ref ID J:31364]

Li X; Sterling JA; Fan KH; Vessella RL; Shyr Y; Hayward SW; Matrisian LM; Bhowmick NA. 2012. Loss of TGF-beta responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res 10(4):494-503. [PubMed: 22290877]  [MGI Ref ID J:205394]

Li Y; Su J; Dingzhang X; Zhang J; Yoshimoto M; Liu S; Bijian K; Gupta A; Squire JA; Alaoui Jamali MA; Bismar TA. 2011. PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome. J Pathol 224(1):90-100. [PubMed: 21381033]  [MGI Ref ID J:171247]

Liao MJ; Zhang XX; Hill R; Gao J; Qumsiyeh MB; Nichols W; Van Dyke T. 1998. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol Cell Biol 18(6):3495-501. [PubMed: 9584189]  [MGI Ref ID J:47667]

Libby SJ; Brehm MA; Greiner DL; Shultz LD; McClelland M; Smith KD; Cookson BT; Karlinsey JE; Kinkel TL; Porwollik S; Canals R; Cummings LA; Fang FC. 2010. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A 107(35):15589-94. [PubMed: 20713716]  [MGI Ref ID J:163745]

Liebe B; Petukhova G; Barchi M; Bellani M; Braselmann H; Nakano T; Pandita TK; Jasin M; Fornace A; Meistrich ML; Baarends WM; Schimenti J; de Lange T; Keeney S; Camerini-Otero RD; Scherthan H. 2006. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res 312(19):3768-81. [PubMed: 17010969]  [MGI Ref ID J:147391]

Liebler JM; Lutzko C; Banfalvi A; Senadheera D; Aghamohammadi N; Crandall ED; Borok Z. 2008. Retention of human bone marrow-derived cells in murine lungs following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 295(2):L285-92. [PubMed: 18515407]  [MGI Ref ID J:138638]

Lieke T; Steeg C; Graefe SE; Fleischer B; Jacobs T. 2006. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. Clin Exp Immunol 145(2):357-64. [PubMed: 16879257]  [MGI Ref ID J:112856]

Liu D; Zhang T; Marshall AJ; Okkenhaug K; Vanhaesebroeck B; Uzonna JE. 2009. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol 183(3):1921-33. [PubMed: 19596993]  [MGI Ref ID J:151583]

Llamas B; Belanger S; Picard S; Deschepper CF. 2007. Cardiac mass and cardiomyocyte size are governed by different genetic loci on either autosomes or chromosome Y in recombinant inbred mice. Physiol Genomics 31(2):176-82. [PubMed: 17566079]  [MGI Ref ID J:127219]

Lode HN; Xiang R; Pertl U; Forster E; Schoenberger SP; Gillies SD; Reisfeld RA. 2000. Melanoma immunotherapy by targeted IL-2 depends on CD4(+) T-cell help mediated by CD40/CD40L interaction. J Clin Invest 105(11):1623-30. [PubMed: 10841521]  [MGI Ref ID J:62762]

Londono D; Bai Y; Zuckert WR; Gelderblom H; Cadavid D. 2005. Cardiac apoptosis in severe relapsing fever borreliosis. Infect Immun 73(11):7669-76. [PubMed: 16239571]  [MGI Ref ID J:104291]

Lou YR; Peng QY; Li T; Medvecky CM; Lin Y; Shih WJ; Conney AH; Shapses S; Wagner GC; Lu YP. 2011. Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis 32(7):1078-84. [PubMed: 21525235]  [MGI Ref ID J:173643]

Lu L; Ghose AK; Quail MR; Albom MS; Durkin JT; Holskin BP; Angeles TS; Meyer SL; Ruggeri BA; Cheng M. 2009. ALK mutants in the kinase domain exhibit altered kinase activity and differential sensitivity to small molecule ALK inhibitors. Biochemistry 48(16):3600-9. [PubMed: 19249873]  [MGI Ref ID J:149248]

Lu M; Kardel MD; O'Connor MD; Eaves CJ. 2009. Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol 37(8):924-36. [PubMed: 19481135]  [MGI Ref ID J:151435]

Lucas S; Taront S; Magnan C; Fauconnier L; Delacre M; Macia L; Delanoye A; Verwaerde C; Spriet C; Saule P; Goormachtigh G; Heliot L; Ktorza A; Movassat J; Polakowska R; Auriault C; Poulain-Godefroy O; Di Santo J; Froguel P; Wolowczuk I. 2012. Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PLoS One 7(6):e40351. [PubMed: 22768283]  [MGI Ref ID J:187900]

Lukacs RU; Memarzadeh S; Wu H; Witte ON. 2010. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 7(6):682-93. [PubMed: 21112563]  [MGI Ref ID J:168487]

Luo X; Tarbell KV; Yang H; Pothoven K; Bailey SL; Ding R; Steinman RM; Suthanthiran M. 2007. Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 104(8):2821-6. [PubMed: 17307871]  [MGI Ref ID J:125908]

MacKenzie DA; Sollinger HW; Hullett DA. 1996. Acute graft rejection of human fetal pancreas allografts using donor-specific human peripheral blood lymphocytes in the SCID mouse. Transplantation 61(10):1461-4. [PubMed: 8633371]  [MGI Ref ID J:33268]

Madlambayan GJ; Meacham AM; Hosaka K; Mir S; Jorgensen M; Scott EW; Siemann DW; Cogle CR. 2010. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116(9):1539-47. [PubMed: 20472832]  [MGI Ref ID J:164541]

Maeda K; Nagasawa H; Furukawa A; Hisaeda H; Himeno K. 1994. Split tolerance between spleen and lymph node cells in severe combined immunodeficiency mice grafted with AKR fetal liver cells. Int Immunol 6(8):1213-9. [PubMed: 7981149]  [MGI Ref ID J:22574]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156]  [MGI Ref ID J:46553]

Majeti R; Park CY; Weissman IL. 2007. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6):635-45. [PubMed: 18371405]  [MGI Ref ID J:142413]

Mamalaki C; Elliott J; Norton T; Yannoutsos N; Townsend AR; Chandler P; Simpson E; Kioussis D. 1993. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. Dev Immunol 3(3):159-74. [PubMed: 8281031]  [MGI Ref ID J:113713]

Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741]  [MGI Ref ID J:146982]

Manis JP; Dudley D; Kaylor L; Alt FW. 2002. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16(4):607-17. [PubMed: 11970883]  [MGI Ref ID J:113521]

Manuel JA; Gawronska-Kozak B. 2006. Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 25(8):505-14. [PubMed: 17010584]  [MGI Ref ID J:116052]

Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980]  [MGI Ref ID J:109851]

Marsden MD; Kovochich M; Suree N; Shimizu S; Mehta R; Cortado R; Bristol G; An DS; Zack JA. 2012. HIV Latency in the Humanized BLT Mouse. J Virol 86(1):339-47. [PubMed: 22072769]  [MGI Ref ID J:179389]

McCool TL; Weiser JN. 2004. Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization. Infect Immun 72(10):5807-13. [PubMed: 15385481]  [MGI Ref ID J:93131]

McDermott SP; Eppert K; Lechman ER; Doedens M; Dick JE. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116(2):193-200. [PubMed: 20404133]  [MGI Ref ID J:162809]

Mehta S; Huillard E; Kesari S; Maire CL; Golebiowski D; Harrington EP; Alberta JA; Kane MF; Theisen M; Ligon KL; Rowitch DH; Stiles CD. 2011. The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma. Cancer Cell 19(3):359-71. [PubMed: 21397859]  [MGI Ref ID J:169930]

Meissner N; Swain S; McInnerney K; Han S; Harmsen AG. 2010. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice. Am J Pathol 176(6):2806-18. [PubMed: 20395428]  [MGI Ref ID J:161163]

Meissner NN; Swain S; Tighe M; Harmsen A; Harmsen A. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174(9):5462-71. [PubMed: 15843544]  [MGI Ref ID J:98407]

Miller RD; Hogg J; Ozaki JH; Gell D; Jackson SP; Riblet R. 1995. Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus. Proc Natl Acad Sci U S A 92(23):10792-5. [PubMed: 7479885]  [MGI Ref ID J:29679]

Mishra R; Chen AT; Welsh RM; Szomolanyi-Tsuda E. 2010. NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. PLoS Pathog 6(5):e1000924. [PubMed: 20523894]  [MGI Ref ID J:162921]

Mizrahi K; Stein J; Pearl-Yafe M; Kaplan O; Yaniv I; Askenasy N. 2010. Regulatory functions of TRAIL in hematopoietic progenitors: human umbilical cord blood and murine bone marrow transplantation. Leukemia 24(7):1325-34. [PubMed: 20485377]  [MGI Ref ID J:162490]

Montecino-Rodriguez E; Leathers H; Dorshkind K. 2006. Identification of a B-1 B cell-specified progenitor. Nat Immunol 7(3):293-301. [PubMed: 16429139]  [MGI Ref ID J:112481]

Monteiro JP; Benjamin A; Costa ES; Barcinski MA; Bonomo A. 2005. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood 105(4):1484-91. [PubMed: 15514013]  [MGI Ref ID J:96600]

Morris SC; Heidorn SM; Herbert DR; Perkins C; Hildeman DA; Khodoun MV; Finkelman FD. 2009. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. J Immunol 182(3):1429-38. [PubMed: 19155490]  [MGI Ref ID J:144327]

Morrison C; Smith GC; Stingl L; Jackson SP; Wagner EF; Wang ZQ. 1997. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 17(4):479-82. [PubMed: 9398855]  [MGI Ref ID J:75374]

Mosier DE; Stell KL; Gulizia RJ; Torbett BE; Gilmore GL. 1993. Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. J Exp Med 177(1):191-4. [PubMed: 8418200]  [MGI Ref ID J:3479]

Mota J; Rico-Hesse R. 2009. Humanized mice show clinical signs of dengue fever according to infecting virus genotype. J Virol 83(17):8638-45. [PubMed: 19535452]  [MGI Ref ID J:153922]

Mustafi R; Dougherty U; Shah H; Dehghan H; Gliksberg A; Wu J; Zhu H; Joseph L; Hart J; Dive C; Fichera A; Threadgill D; Bissonnette M. 2012. Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. Carcinogenesis 33(10):1930-9. [PubMed: 22791816]  [MGI Ref ID J:192954]

Mutwiri G K; Kosecka U; Benjamin M; Rosendal S; Perdue M; Butler D G. 2001. Mycobacterium avium subspecies paratuberculosis triggers intestinal pathophysiologic changes in beige/scid mice. Comp Med 51(6):538-44. [PubMed: 11924817]  [MGI Ref ID J:73720]

Nacht M; Strasser A; Chan YR; Harris AW; Schlissel M; Bronson RT; Jacks T. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev 10(16):2055-66. [PubMed: 8769648]  [MGI Ref ID J:35055]

Nakayama M; Beilke JN; Jasinski JM; Kobayashi M; Miao D; Li M; Coulombe MG; Liu E; Elliott JF; Gill RG; Eisenbarth GS. 2007. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest 117(7):1835-43. [PubMed: 17607359]  [MGI Ref ID J:124210]

Naramura M; Nandwani N; Gu H; Band V; Band H. 2010. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A 107(37):16274-9. [PubMed: 20805496]  [MGI Ref ID J:164365]

Nemoto Y; Kanai T; Takahara M; Oshima S; Okamoto R; Tsuchiya K; Matsumoto S; Watanabe M. 2013. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J Immunol 190(12):6616-25. [PubMed: 23670188]  [MGI Ref ID J:204854]

Niimi N; Sugo N; Aratani Y; Koyama H. 2005. Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ 12(2):184-91. [PubMed: 15647757]  [MGI Ref ID J:106364]

Nishiyama Y; Hamada H; Nonaka S; Yamamoto H; Nanno M; Katayama Y; Takahashi H; Ishikawa H. 2002. Homeostatic regulation of intestinal villous epithelia by B lymphocytes. J Immunol 168(6):2626-33. [PubMed: 11884426]  [MGI Ref ID J:126867]

Nonaka S; Naito T; Chen H; Yamamoto M; Moro K; Kiyono H; Hamada H; Ishikawa H. 2005. Intestinal gammadelta T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J Immunol 174(4):1906-12. [PubMed: 15699117]  [MGI Ref ID J:96579]

Nonoyama S; Smith FO; Bernstein ID; Ochs HD. 1993. Strain-dependent leakiness of mice with severe combined immune deficiency. J Immunol 150(9):3817-24. [PubMed: 8473734]  [MGI Ref ID J:4610]

Noorchashm H; Reed AJ; Rostami SY; Mozaffari R; Zekavat G; Koeberlein B; Caton AJ; Naji A. 2006. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol 177(11):7715-22. [PubMed: 17114442]  [MGI Ref ID J:140848]

Notley CA; Inglis JJ; Alzabin S; McCann FE; McNamee KE; Williams RO. 2008. Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205(11):2491-7. [PubMed: 18936235]  [MGI Ref ID J:140651]

O'Boyle G; Fox CR; Walden HR; Willet JD; Mavin ER; Hine DW; Palmer JM; Barker CE; Lamb CA; Ali S; Kirby JA. 2012. Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation. Proc Natl Acad Sci U S A 109(12):4598-603. [PubMed: 22392992]  [MGI Ref ID J:182231]

O'Hara JR; Skinn AC; MacNaughton WK; Sherman PM; Sharkey KA. 2006. Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon. Cell Microbiol 8(4):646-60. [PubMed: 16548890]  [MGI Ref ID J:135756]

O'Malley JT; Eri RD; Stritesky GL; Mathur AN; Chang HC; Hogenesch H; Srinivasan M; Kaplan MH. 2008. STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol 181(7):5062-70. [PubMed: 18802110]  [MGI Ref ID J:142733]

O'Reilly LA; Harris AW; Strasser A. 1997. bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors. Int Immunol 9(9):1291-301. [PubMed: 9310832]  [MGI Ref ID J:93122]

O'Reilly LA; Harris AW; Tarlinton DM; Corcoran LM; Strasser A. 1997. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. J Immunol 159(5):2301-11. [PubMed: 9278319]  [MGI Ref ID J:93123]

Ochiai M; Ubagai T; Kawamori T; Imai H; Sugimura T; Nakagama H. 2001. High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase. Carcinogenesis 22(9):1551-5. [PubMed: 11532879]  [MGI Ref ID J:84343]

Ohsugi T; Kiuchi Y; Shimoda K; Oguri S; Maejima K. 1996. Translocation of bacteria from the gastrointestinal tract in immunodeficient mice. Lab Anim 30(1):46-50. [PubMed: 8709573]  [MGI Ref ID J:31261]

Oida T; Suzuki K; Nanno M; Kanamori Y; Saito H; Kubota E; Kato S; Itoh M; Kaminogawa S; Ishikawa H. 2000. Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. J Immunol 164(7):3616-26. [PubMed: 10725718]  [MGI Ref ID J:112139]

Okada K; Shoda J; Taguchi K; Maher JM; Ishizaki K; Inoue Y; Ohtsuki M; Goto N; Takeda K; Utsunomiya H; Oda K; Warabi E; Ishii T; Osaka K; Hyodo I; Yamamoto M. 2008. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol 295(4):G735-47. [PubMed: 18687751]  [MGI Ref ID J:142149]

Okazaki T; Okazaki IM; Wang J; Sugiura D; Nakaki F; Yoshida T; Kato Y; Fagarasan S; Muramatsu M; Eto T; Hioki K; Honjo T. 2011. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med 208(2):395-407. [PubMed: 21300912]  [MGI Ref ID J:176845]

Okazuka K; Wakabayashi Y; Kashihara M; Inoue J; Sato T; Yokoyama M; Aizawa S; Aizawa Y; Mishima Y; Kominami R. 2005. p53 prevents maturation of T cell development to the immature CD4(-)CD8(+) stage in Bcl11b(-/-) mice. Biochem Biophys Res Commun 328(2):545-549. [PubMed: 15694382]  [MGI Ref ID J:96179]

Omori K; Mitsuhashi M; Ishiyama K; Nair I; Rawson J; Todorov I; Kandeel F; Mullen Y. 2011. mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-alpha-induced islet damage in humans. Diabetologia 54(8):2056-66. [PubMed: 21567299]  [MGI Ref ID J:175299]

Opata MM; Ye Z; Hollifield M; Garvy BA. 2013. B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice. Infect Immun 81(11):4252-60. [PubMed: 24002064]  [MGI Ref ID J:201876]

Origanti S; Cai SR; Munir AZ; White LS; Piwnica-Worms H. 2013. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene 32(5):577-88. [PubMed: 22430210]  [MGI Ref ID J:193369]

Osmond DG; Kim N; Manoukian R; Phillips RA; Rico-Vargas SA; Jacobsen K. 1992. Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice. Blood 79(7):1695-703. [PubMed: 1373084]  [MGI Ref ID J:737]

Owyang AM; Zaph C; Wilson EH; Guild KJ; McClanahan T; Miller HR; Cua DJ; Goldschmidt M; Hunter CA; Kastelein RA; Artis D. 2006. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 203(4):843-9. [PubMed: 16606667]  [MGI Ref ID J:123808]

Ozaki H; Mori K; Nakagawa Y; Hoshikawa S; Ito S; Inoue Y; Takai T; Yoshida K. 2009. Autoimmune thyroiditis in Fcgamma receptor-deficient nonobese diabetic mice. Clin Immunol 132(2):291-3. [PubMed: 19447681]  [MGI Ref ID J:151452]

Paciorkowski N; Porte P; Shultz LD; Rajan TV. 2000. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med 191(4):731-6. [PubMed: 10684864]  [MGI Ref ID J:112016]

Paliwal P; Conboy IM. 2011. Inhibitors of tyrosine phosphatases and apoptosis reprogram lineage-marked differentiated muscle to myogenic progenitor cells. Chem Biol 18(9):1153-66. [PubMed: 21944754]  [MGI Ref ID J:190199]

Pancewicz J; Taylor JM; Datta A; Baydoun HH; Waldmann TA; Hermine O; Nicot C. 2010. Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. Proc Natl Acad Sci U S A 107(38):16619-24. [PubMed: 20823234]  [MGI Ref ID J:164350]

Papagiannakopoulos T; Friedmann-Morvinski D; Neveu P; Dugas JC; Gill RM; Huillard E; Liu C; Zong H; Rowitch DH; Barres BA; Verma IM; Kosik KS. 2012. Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene 31(15):1884-95. [PubMed: 21874051]  [MGI Ref ID J:186143]

Papeta N; Zheng Z; Schon EA; Brosel S; Altintas MM; Nasr SH; Reiser J; D'Agati VD; Gharavi AG. 2010. Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest 120(11):4055-64. [PubMed: 20978358]  [MGI Ref ID J:166909]

Park CW; Ryu HW; Ryu KY. 2012. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb. Biochem Biophys Res Commun 418(3):541-6. [PubMed: 22285186]  [MGI Ref ID J:181255]

Pauza ME; Dobbs CM; He J; Patterson T; Wagner S; Anobile BS; Bradley BJ; Lo D; Haskins K. 2004. T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes 53(4):978-88. [PubMed: 15047613]  [MGI Ref ID J:89082]

Pearson T; Greiner DL; Shultz LD. 2008. Creation of 'humanized' mice to study human immunity. Curr Protoc Immunol Chapter 15:Unit 15.21. [PubMed: 18491294]  [MGI Ref ID J:151386]

Pearson T; Shultz LD; Lief J; Burzenski L; Gott B; Chase T; Foreman O; Rossini AA; Bottino R; Trucco M; Greiner DL. 2008. A new immunodeficient hyperglycaemic mouse model based on the Ins2 ( Akita ) mutation for analyses of human islet and beta stem and progenitor cell function. Diabetologia 51(8):1449-56. [PubMed: 18563383]  [MGI Ref ID J:138005]

Pearson T; Shultz LD; Miller D; King M; Laning J; Fodor W; Cuthbert A; Burzenski L; Gott B; Lyons B; Foreman O; Rossini AA; Greiner DL. 2008. Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment. Clin Exp Immunol 154(2):270-84. [PubMed: 18785974]  [MGI Ref ID J:140388]

Pedraza-Alva G; Koulnis M; Charland C; Thornton T; Clements JL; Schlissel MS; Rincon M. 2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint. EMBO J 25(4):763-73. [PubMed: 16456545]  [MGI Ref ID J:105987]

Pei Y; Moore CE; Wang J; Tewari AK; Eroshkin A; Cho YJ; Witt H; Korshunov A; Read TA; Sun JL; Schmitt EM; Miller CR; Buckley AF; McLendon RE; Westbrook TF; Northcott PA; Taylor MD; Pfister SM; Febbo PG; Wechsler-Reya RJ. 2012. An Animal Model of MYC-Driven Medulloblastoma. Cancer Cell 21(2):155-67. [PubMed: 22340590]  [MGI Ref ID J:181463]

Percy DH; Auger DC; Croy BA. 1994. Signs and lesions of experimental Sendai virus infection in two genetically distinct strains of SCID/beige mice. Vet Pathol 31(1):67-73. [PubMed: 8140728]  [MGI Ref ID J:17913]

Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. [PubMed: 8320959]  [MGI Ref ID J:4752]

Perone MJ; Bertera S; Tawadrous ZS; Shufesky WJ; Piganelli JD; Baum LG; Trucco M; Morelli AE. 2006. Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol 177(8):5278-89. [PubMed: 17015713]  [MGI Ref ID J:139444]

Petitto JM; Huang Z; Lo J; Streit WJ. 2003. IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons. J Neuroimmunol 134(1-2):95-103. [PubMed: 12507776]  [MGI Ref ID J:105891]

Phillips JM; Parish NM; Drage M; Cooke A. 2001. Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes. J Immunol 167(11):6087-91. [PubMed: 11714766]  [MGI Ref ID J:119045]

Pierce EM; Carpenter K; Jakubzick C; Kunkel SL; Flaherty KR; Martinez FJ; Hogaboam CM. 2007. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol 170(4):1152-64. [PubMed: 17392156]  [MGI Ref ID J:120124]

Pierce MA; Chapman HD; Post CM; Svetlanov A; Efrat S; Horwitz M; Serreze DV. 2003. Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes 52(5):1119-27. [PubMed: 12716741]  [MGI Ref ID J:83195]

Porubsky S; Wang S; Kiss E; Dehmel S; Bonrouhi M; Dorn T; Luckow B; Brakebusch C; Grone HJ. 2011. Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection. Eur J Immunol 41(1):76-88. [PubMed: 21182079]  [MGI Ref ID J:174659]

Powrie F; Leach MW; Mauze S; Menon S; Caddle LB; Coffman RL. 1994. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1(7):553-62. [PubMed: 7600284]  [MGI Ref ID J:133778]

Prochazka M; Gaskins HR; Shultz LD; Leiter EH. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc Natl Acad Sci U S A 89(8):3290-4. [PubMed: 1373493]  [MGI Ref ID J:513]

Qing Y; Lin Y; Gerson SL. 2012. An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood 119(7):1768-71. [PubMed: 22147896]  [MGI Ref ID J:181738]

Qualls JE; Kaplan AM; van Rooijen N; Cohen DA. 2006. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 80(4):802-15. [PubMed: 16888083]  [MGI Ref ID J:113033]

Quintana E; Shackleton M; Sabel MS; Fullen DR; Johnson TM; Morrison SJ. 2008. Efficient tumour formation by single human melanoma cells. Nature 456(7222):593-8. [PubMed: 19052619]  [MGI Ref ID J:142408]

Rappa G; Mercapide J; Lorico A. 2012. Spontaneous Formation of Tumorigenic Hybrids between Breast Cancer and Multipotent Stromal Cells Is a Source of Tumor Heterogeneity. Am J Pathol 180(6):2504-15. [PubMed: 22542847]  [MGI Ref ID J:184798]

Rauch DA; Hurchla MA; Harding JC; Deng H; Shea LK; Eagleton MC; Niewiesk S; Lairmore MD; Piwnica-Worms D; Rosol TJ; Weber JD; Ratner L; Weilbaecher KN. 2010. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 5(12):e15755. [PubMed: 21209895]  [MGI Ref ID J:168312]

Rauner G; Leviav A; Mavor E; Barash I. 2013. Development of Foreign Mammary Epithelial Morphology in the Stroma of Immunodeficient Mice. PLoS One 8(6):e68637. [PubMed: 23825700]  [MGI Ref ID J:204342]

Read TA; Fogarty MP; Markant SL; McLendon RE; Wei Z; Ellison DW; Febbo PG; Wechsler-Reya RJ. 2009. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 15(2):135-47. [PubMed: 19185848]  [MGI Ref ID J:144811]

Riggs J; Stowers R. 1996. Ability of spleen, peritoneal cavity, and lymph node B cells to reconstitute serum immunoglobulin in SCID mice. Immunology 88(1):20-7. [PubMed: 8707345]  [MGI Ref ID J:32916]

Riggs JE; Feeney AJ; Kirven M; Mosier DE. 1994. VH11 bias and normal V-D-J junctions in SCID B lymphocytes rescued by neonatal T cell transfer. Mol Immunol 31(11):783-91. [PubMed: 8047070]  [MGI Ref ID J:19789]

Rival C; Samy E; Setiady Y; Tung K. 2013. Cutting edge: Ly49C/I(-) neonatal NK cells predispose newborns to autoimmune ovarian disease induced by maternal autoantibody. J Immunol 191(6):2865-9. [PubMed: 23960238]  [MGI Ref ID J:205867]

Rivera J; Zaragoza O; Casadevall A. 2005. Antibody-mediated protection against Cryptococcus neoformans pulmonary infection is dependent on B cells. Infect Immun 73(2):1141-50. [PubMed: 15664957]  [MGI Ref ID J:95620]

Roberts JL; Abe R; Shores EW; Singer A. 1992. Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. J Immunol 149(5):1577-82. [PubMed: 1506683]  [MGI Ref ID J:2072]

Rochford R; Ohrt C; Baresel PC; Campo B; Sampath A; Magill AJ; Tekwani BL; Walker LA. 2013. Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity. Proc Natl Acad Sci U S A 110(43):17486-91. [PubMed: 24101478]  [MGI Ref ID J:201977]

Rolink A; Melchers F; Andersson J. 1996. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Immunity 5(4):319-30. [PubMed: 8885865]  [MGI Ref ID J:36026]

Rosario CO; Ko MA; Haffani YZ; Gladdy RA; Paderova J; Pollett A; Squire JA; Dennis JW; Swallow CJ. 2010. Plk4 is required for cytokinesis and maintenance of chromosomal stability. Proc Natl Acad Sci U S A 107(15):6888-93. [PubMed: 20348415]  [MGI Ref ID J:159310]

Roths JB; Smith AL; Sidman CL. 1993. Lethal exacerbation of Pneumocystis carinii pneumonia in severe combined immunodeficiency mice after infection by pneumonia virus of mice. J Exp Med 177(4):1193-8. [PubMed: 8459214]  [MGI Ref ID J:109921]

Rotolo JA; Mesicek J; Maj J; Truman JP; Haimovitz-Friedman A; Kolesnick R; Fuks Z. 2010. Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes. Cancer Res 70(3):957-67. [PubMed: 20086180]  [MGI Ref ID J:156862]

Ruan S; McKinley L; Zheng M; Rudner X; D'Souza A; Kolls JK; Shellito JE. 2008. Interleukin-12 and host defense against murine Pneumocystis pneumonia. Infect Immun 76(5):2130-7. [PubMed: 18332204]  [MGI Ref ID J:134470]

Ruetsch NR; Bosma GC; Bosma MJ. 2000. Unexpected rearrangement and expression of the immunoglobulin lambda1 locus in scid mice. J Exp Med 191(11):1933-43. [PubMed: 10839808]  [MGI Ref ID J:62701]

Rynda-Apple A; Dobrinen E; McAlpine M; Read A; Harmsen A; Richert LE; Calverley M; Pallister K; Voyich J; Wiley JA; Johnson B; Young M; Douglas T; Harmsen AG. 2012. Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function. Am J Pathol 181(1):196-210. [PubMed: 22642909]  [MGI Ref ID J:185523]

Salem ML; Al-Khami AA; El-Naggar SA; Diaz-Montero CM; Chen Y; Cole DJ. 2010. Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol 184(4):1737-47. [PubMed: 20083664]  [MGI Ref ID J:159482]

Samy ET; Meyer CA; Caplazi P; Langrish CL; Lora JM; Bluethmann H; Peng SL. 2007. Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. J Immunol 179(9):5644-8. [PubMed: 17947634]  [MGI Ref ID J:153014]

Santidrian AF; Matsuno-Yagi A; Ritland M; Seo BB; LeBoeuf SE; Gay LJ; Yagi T; Felding-Habermann B. 2013. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123(3):1068-81. [PubMed: 23426180]  [MGI Ref ID J:196392]

Saville SP; Lazzell AL; Chaturvedi AK; Monteagudo C; Lopez-Ribot JL. 2008. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun 76(1):97-102. [PubMed: 17967861]  [MGI Ref ID J:130296]

Savinov AY; Rozanov DV; Strongin AY. 2007. Specific inhibition of autoimmune T cell transmigration contributes to beta cell functionality and insulin synthesis in non-obese diabetic (NOD) mice. J Biol Chem 282(44):32106-11. [PubMed: 17761671]  [MGI Ref ID J:126809]

Savinov AY; Tcherepanov A; Green EA; Flavell RA; Chervonsky AV. 2003. Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A 100(2):628-32. [PubMed: 12525697]  [MGI Ref ID J:81416]

Savouret C; Brisson E; Essers J; Kanaar R; Pastink A; te Riele H; Junien C; Gourdon G. 2003. CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J 22(9):2264-73. [PubMed: 12727892]  [MGI Ref ID J:83373]

Schito ML; Barta JR. 1997. Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice. Infect Immun 65(8):3165-70. [PubMed: 9234770]  [MGI Ref ID J:41839]

Schmidt RE; Dorsey DA; Beaudet LN; Frederick KE; Parvin CA; Plurad SB; Levisetti MG. 2003. Non-obese diabetic mice rapidly develop dramatic sympathetic neuritic dystrophy: a new experimental model of diabetic autonomic neuropathy. Am J Pathol 163(5):2077-91. [PubMed: 14578206]  [MGI Ref ID J:86318]

Schon MP; Schon M; Warren HB; Donohue JP; Parker CM. 2000. Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice. J Immunol 165(11):6583-9. [PubMed: 11086102]  [MGI Ref ID J:110810]

Schuler W; Weiler IJ; Schuler A; Phillips RA; Rosenberg N; Mak TW; Kearney JF; Perry RP; Bosma MJ. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46(7):963-72. [PubMed: 3093081]  [MGI Ref ID J:8420]

Searles S; Gauss K; Wilkison M; Hoyt TR; Dobrinen E; Meissner N. 2013. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection. J Immunol 191(7):3884-95. [PubMed: 23975863]  [MGI Ref ID J:205844]

Seif AE; Barrett DM; Milone M; Brown VI; Grupp SA; Reid GS. 2009. Long-term protection from syngeneic acute lymphoblastic leukemia by CpG ODN-mediated stimulation of innate and adaptive immune responses. Blood 114(12):2459-66. [PubMed: 19636062]  [MGI Ref ID J:152910]

Sekiguchi J; Ferguson DO; Chen HT; Yang EM; Earle J; Frank K; Whitlow S; Gu Y; Xu Y; Nussenzweig A; Alt FW. 2001. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A 98(6):3243-8. [PubMed: 11248063]  [MGI Ref ID J:68074]

Sela U; Olds P; Park A; Schlesinger SJ; Steinman RM. 2011. Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice. J Exp Med 208(12):2489-96. [PubMed: 22084406]  [MGI Ref ID J:178615]

Serpe CJ; Kohm AP; Huppenbauer CB; Sanders VM; Jones KJ. 1999. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice. J Neurosci 19(11):RC7. [PubMed: 10341268]  [MGI Ref ID J:120563]

Serreze DV; Chapman HD; Varnum DS; Gerling I; Leiter EH; Shultz LD. 1997. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol 158(8):3978-86. [PubMed: 9103469]  [MGI Ref ID J:39473]

Serreze DV; Johnson EA; Chapman HD; Graser RT; Marron MP; DiLorenzo TP; Silveira P; Yoshimura Y; Nathenson SG; Joyce S. 2001. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 50(9):1992-2000. [PubMed: 11522664]  [MGI Ref ID J:71050]

Serreze DV; Leiter EH; Hanson MS; Christianson SW; Shultz LD; Hesselton RM; Greiner DL. 1995. Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells. Diabetes 44(12):1392-8. [PubMed: 7589844]  [MGI Ref ID J:29951]

Severe S; Gauvrit A; Vu AT; Bach JM. 2007. CD8(+) T lymphocytes specific for glutamic acid decarboxylase 90-98 epitope mediate diabetes in NOD(SCID) mouse. Mol Immunol 44(11):2950-60. [PubMed: 17336387]  [MGI Ref ID J:119811]

Shellito JE; Kolls JK; Olariu R; Beck JM. 1996. Nitric oxide and host defense against Pneumocystis carinii infection in a mouse model. J Infect Dis 173(2):432-9. [PubMed: 8568306]  [MGI Ref ID J:31163]

Shibata S; Asano T; Ogura A; Hashimoto N; Hayakawa J; Uetsuka K ; Nakayama H ; Doi K. 1997. SCID-bg mice as xenograft recipients. Lab Anim 31(2):163-8. [PubMed: 9175014]  [MGI Ref ID J:40569]

Shoji S; Watanabe H; Katoh O; Masaoka Y; Matsuura S; Tauchi H; Endo S; Komatsu K. 1998. Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos. Int J Radiat Biol 73(6):705-9. [PubMed: 9690689]  [MGI Ref ID J:51083]

Shores EW; Nakayama T; Wiest DL; Takahama Y; Sharrow S; Singer A. 1993. Structurally distinct T cell receptor complexes on developmentally distinct T cell populations in severe combined immunodeficiency mice expressing a TCR beta transgene. J Immunol 150(4):1263-75. [PubMed: 8094405]  [MGI Ref ID J:111476]

Shultz LD; Banuelos S; Lyons B; Samuels R; Burzenski L; Gott B; Lang P; Leif J; Appel M; Rossini A; Greiner DL. 2003. NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. Transplantation 76(7):1036-42. [PubMed: 14557749]  [MGI Ref ID J:109843]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Shultz LD; Lyons BL; Burzenski LM; Gott B; Chen X; Chaleff S; Kotb M; Gillies SD; King M; Mangada J; Greiner DL; Handgretinger R. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174(10):6477-89. [PubMed: 15879151]  [MGI Ref ID J:109833]

Shultz LD; Saito Y; Najima Y; Tanaka S; Ochi T; Tomizawa M; Doi T; Sone A; Suzuki N; Fujiwara H; Yasukawa M; Ishikawa F. 2010. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci U S A 107(29):13022-7. [PubMed: 20615947]  [MGI Ref ID J:162315]

Shultz LD; Schweitzer PA; Christianson SW; Gott B; Schweitzer IB; Tennent B; McKenna S; Mobraaten L; Rajan TV; Greiner DL; Leiter EH. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154(1):180-91. [PubMed: 7995938]  [MGI Ref ID J:22026]

Shurin MR; Potapovich AI; Tyurina YY; Tourkova IL; Shurin GV; Kagan VE. 2009. Recognition of live phosphatidylserine-labeled tumor cells by dendritic cells: a novel approach to immunotherapy of skin cancer. Cancer Res 69(6):2487-96. [PubMed: 19276376]  [MGI Ref ID J:147072]

Simard C; Klein SJ; Mak T; Jolicoeur P. 1997. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus. J Virol 71(4):3013-22. [PubMed: 9060661]  [MGI Ref ID J:38897]

Simons BW; Hurley PJ; Huang Z; Ross AE; Miller R; Marchionni L; Berman DM; Schaeffer EM. 2012. Wnt signaling though beta-catenin is required for prostate lineage specification. Dev Biol 371(2):246-55. [PubMed: 22960283]  [MGI Ref ID J:190538]

Simpson-Abelson MR; Sonnenberg GF; Takita H; Yokota SJ; Conway TF Jr; Kelleher RJ Jr; Shultz LD; Barcos M; Bankert RB. 2008. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol 180(10):7009-18. [PubMed: 18453623]  [MGI Ref ID J:142412]

Smythies LE; Waites KB; Lindsey JR; Harris PR; Ghiara P; Smith PD. 2000. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165(2):1022-9. [PubMed: 10878379]  [MGI Ref ID J:120556]

Song X; Guo Y; Duo S; Che J; Wu C; Ochiya T; Ding M; Deng H. 2009. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol 175(5):1975-83. [PubMed: 19808649]  [MGI Ref ID J:154703]

Spranger S; Jeremias I; Wilde S; Leisegang M; Starck L; Mosetter B; Uckert W; Heemskerk MH; Schendel DJ; Frankenberger B. 2012. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. Blood 119(15):3440-9. [PubMed: 22371883]  [MGI Ref ID J:183769]

Stalder AK; Carson MJ; Pagenstecher A; Asensio VC; Kincaid C; Benedict M; Powell HC; Masliah E; Campbell IL. 1998. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am J Pathol 153(3):767-83. [PubMed: 9736027]  [MGI Ref ID J:106595]

Stokes KY; Calahan L; Hamric CM; Russell JM; Granger DN. 2009. CD40/CD40L contributes to hypercholesterolemia-induced microvascular inflammation. Am J Physiol Heart Circ Physiol 296(3):H689-97. [PubMed: 19112095]  [MGI Ref ID J:146361]

Stone JL; McMillan RE; Skaar DA; Bradshaw JM; Jirtle RL; Sikes ML. 2012. DNA Double-Strand Breaks Relieve USF-Mediated Repression of Dbeta2 Germline Transcription in Developing Thymocytes. J Immunol 188(5):2266-75. [PubMed: 22287717]  [MGI Ref ID J:181246]

Stracker TH; Couto SS; Cordon-Cardo C; Matos T; Petrini JH. 2008. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell 31(1):21-32. [PubMed: 18614044]  [MGI Ref ID J:138550]

Stracker TH; Williams BR; Deriano L; Theunissen JW; Adelman CA; Roth DB; Petrini JH. 2009. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol 29(2):503-14. [PubMed: 19015239]  [MGI Ref ID J:144749]

Strasser A; Harris AW; Corcoran LM; Cory S. 1994. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368(6470):457-60. [PubMed: 8133891]  [MGI Ref ID J:17426]

Stratford EW; Bostad M; Castro R; Skarpen E; Berg K; Hogset A; Myklebost O; Selbo PK. 2013. Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity. Biochim Biophys Acta 1830(8):4235-43. [PubMed: 23643966]  [MGI Ref ID J:202381]

Strowig T; Chijioke O; Carrega P; Arrey F; Meixlsperger S; Ramer PC; Ferlazzo G; Munz C. 2010. Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood 116(20):4158-67. [PubMed: 20671122]  [MGI Ref ID J:167434]

Su MA; Davini D; Cheng P; Giang K; Fan U; DeVoss JJ; Johannes KP; Taylor L; Shum AK; Valenzise M; Meloni A; Bour-Jordan H; Anderson MS. 2012. Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. J Immunol 188(10):4906-12. [PubMed: 22490868]  [MGI Ref ID J:188686]

Su X; Hu Q; Kristan JM; Costa C; Shen Y; Gero D; Matis LA; Wang Y. 2000. Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol 164(5):2523-32. [PubMed: 10679090]  [MGI Ref ID J:127009]

Suffia I; Reckling SK; Salay G; Belkaid Y. 2005. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol 174(9):5444-55. [PubMed: 15845457]  [MGI Ref ID J:98414]

Sugiarto S; Persson AI; Munoz EG; Waldhuber M; Lamagna C; Andor N; Hanecker P; Ayers-Ringler J; Phillips J; Siu J; Lim DA; Vandenberg S; Stallcup W; Berger MS; Bergers G; Weiss WA; Petritsch C. 2011. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328-40. [PubMed: 21907924]  [MGI Ref ID J:175969]

Sugiura K; Taketani S; Yoshimura T; Nishino T; Nishino N; Fujisawa J; Hisha H; Inaba T; Ikehara S. 2007. Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice. Cytokine 37(3):218-26. [PubMed: 17512212]  [MGI Ref ID J:126823]

Sun X; Robertson SA; Ingman WV. 2013. Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland. Cytokine 61(2):377-88. [PubMed: 23290315]  [MGI Ref ID J:197873]

Sundberg JP (ed.). 1994. Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Adkison DL; Bedigian HG. 1991. Skeletal muscle rhabdomyosarcomas in inbred laboratory mice. Vet Pathol 28(3):200-6. [PubMed: 1830433]  [MGI Ref ID J:24311]

Swaims AY; Khani F; Zhang Y; Roberts AI; Devadas S; Shi Y; Rabson AB. 2010. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 116(16):2994-3003. [PubMed: 20634377]  [MGI Ref ID J:165866]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Szomolanyi-Tsuda E; Dundon PL; Joris I; Shultz LD; Woda BA; Welsh RM. 1994. Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice. Am J Pathol 144(2):359-71. [PubMed: 8311119]  [MGI Ref ID J:16875]

Ta VB; de Haan AB; de Bruijn MJ; Dingjan GM; Hendriks RW. 2011. Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity. Leukemia 25(1):48-56. [PubMed: 21030983]  [MGI Ref ID J:167638]

Tadokoro Y; Ema H; Okano M; Li E; Nakauchi H. 2007. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J Exp Med 204(4):715-22. [PubMed: 17420264]  [MGI Ref ID J:125606]

Takagi S; Saito Y; Hijikata A; Tanaka S; Watanabe T; Hasegawa T; Mochizuki S; Kunisawa J; Kiyono H; Koseki H; Ohara O; Saito T; Taniguchi S; Shultz LD; Ishikawa F. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood :. [PubMed: 22279057]  [MGI Ref ID J:180274]

Takahama Y; Sugaya K; Tsuda S; Hasegawa T; Hashimoto Y. 1995. Regulation of early T cell development by the engagement of TCR-beta complex expressed on fetal thymocytes from TCR-beta-transgenic scid mice. J Immunol 154(11):5862-9. [PubMed: 7751632]  [MGI Ref ID J:25533]

Takahashi Y; Inamine A; Hashimoto S; Haraguchi S; Yoshioka E; Kojima N; Abe R; Takemori T. 2005. Novel role of the Ras cascade in memory B cell response. Immunity 23(2):127-38. [PubMed: 16111632]  [MGI Ref ID J:100532]

Takata M; Nakagomi T; Kashiwamura S; Nakano-Doi A; Saino O; Nakagomi N; Okamura H; Mimura O; Taguchi A; Matsuyama T. 2012. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ 19(5):756-67. [PubMed: 22052192]  [MGI Ref ID J:203071]

Takenaka K; Prasolava TK; Wang JC; Mortin-Toth SM; Khalouei S; Gan OI; Dick JE; Danska JS. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat Immunol 8(12):1313-23. [PubMed: 17982459]  [MGI Ref ID J:127760]

Takeuchi D; Jones VC; Kobayashi M; Suzuki F. 2008. Cooperative role of macrophages and neutrophils in host Antiprotozoan resistance in mice acutely infected with Cryptosporidium parvum. Infect Immun 76(8):3657-63. [PubMed: 18519557]  [MGI Ref ID J:139362]

Tanaka S; Saito Y; Kunisawa J; Kurashima Y; Wake T; Suzuki N; Shultz LD; Kiyono H; Ishikawa F. 2012. Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rgammaKO mice. J Immunol 188(12):6145-55. [PubMed: 22611244]  [MGI Ref ID J:188959]

Thayer TC; Delano M; Liu C; Chen J; Padgett LE; Tse HM; Annamali M; Piganelli JD; Moldawer LL; Mathews CE. 2011. Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes 60(8):2144-51. [PubMed: 21715554]  [MGI Ref ID J:186804]

Thomas DC; Mellanby RJ; Phillips JM; Cooke A. 2007. An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology 121(4):565-76. [PubMed: 17437531]  [MGI Ref ID J:125536]

Touvrey C; Couedel C; Soulas P; Couderc R; Jasin M; de Villartay JP; Marche PN; Jouvin-Marche E; Candeias SM. 2008. Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol 45(12):3383-91. [PubMed: 18501428]  [MGI Ref ID J:137712]

Trowbridge JJ; Scott MP; Bhatia M. 2006. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 103(38):14134-9. [PubMed: 16968775]  [MGI Ref ID J:113717]

Tsai S; Serra P; Clemente-Casares X; Slattery RM; Santamaria P. 2013. Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II. J Immunol 191(1):70-82. [PubMed: 23740949]  [MGI Ref ID J:205347]

Tsai S; Shameli A; Yamanouchi J; Clemente-Casares X; Wang J; Serra P; Yang Y; Medarova Z; Moore A; Santamaria P. 2010. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 32(4):568-80. [PubMed: 20381385]  [MGI Ref ID J:179859]

Tsuchiya T; Fukuda S; Hamada H; Nakamura A; Kohama Y; Ishikawa H; Tsujikawa K; Yamamoto H. 2003. Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol 171(10):5507-13. [PubMed: 14607957]  [MGI Ref ID J:106734]

Tsuji H; Ishii-Ohba H; Noda Y; Kubo E; Furuse T; Tatsumi K. 2009. Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice. Mutat Res 660(1-2):22-32. [PubMed: 19000702]  [MGI Ref ID J:144042]

Tsuji Y; Watanabe T; Kudo M; Arai H; Strober W; Chiba T. 2012. Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis. Immunity 37(2):326-38. [PubMed: 22902233]  [MGI Ref ID J:187368]

Tucker TA; Kundert JA; Bondareva AA; Schmidt EE. 2005. Reproductive and neurological Quakingviable phenotypes in a severe combined immune deficient mouse background. Immunogenetics 57(3-4):226-31. [PubMed: 15900494]  [MGI Ref ID J:98496]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068]  [MGI Ref ID J:104385]

Uhlig HH; McKenzie BS; Hue S; Thompson C; Joyce-Shaikh B; Stepankova R; Robinson N; Buonocore S; Tlaskalova-Hogenova H; Cua DJ; Powrie F. 2006. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25(2):309-18. [PubMed: 16919486]  [MGI Ref ID J:113470]

Unsinger J; McDonough JS; Shultz LD; Ferguson TA; Hotchkiss RS. 2009. Sepsis-induced human lymphocyte apoptosis and cytokine production in 'humanized' mice. J Leukoc Biol 86(2):219-27. [PubMed: 19369639]  [MGI Ref ID J:151270]

Van Buul PP; De Rooij DG; Zandman IM; Grigorova M; Van Duyn-Goedhart A. 1995. X-ray-induced chromosomal aberrations and cell killing in somatic and germ cells of the scid mouse. Int J Radiat Biol 67(5):549-55. [PubMed: 7775830]  [MGI Ref ID J:26914]

VanBuskirk KM; O'Neill MT; De La Vega P; Maier AG; Krzych U; Williams J; Dowler MG; Sacci JB Jr; Kangwanrangsan N; Tsuboi T; Kneteman NM; Heppner DG Jr; Murdock BA; Mikolajczak SA; Aly AS; Cowman AF; Kappe SH. 2009. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A 106(31):13004-9. [PubMed: 19625622]  [MGI Ref ID J:152010]

Vemuri MC; Schiller E; Naegele JR. 2001. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ 8(3):245-55. [PubMed: 11319607]  [MGI Ref ID J:115402]

Verma-Gandhu M; Bercik P; Motomura Y; Verdu EF; Khan WI; Blennerhassett PA; Wang L; El-Sharkawy RT; Collins SM. 2006. CD4+ T-cell modulation of visceral nociception in mice. Gastroenterology 130(6):1721-8. [PubMed: 16697736]  [MGI Ref ID J:124915]

Viatour P; Ehmer U; Saddic LA; Dorrell C; Andersen JB; Lin C; Zmoos AF; Mazur PK; Schaffer BE; Ostermeier A; Vogel H; Sylvester KG; Thorgeirsson SS; Grompe M; Sage J. 2011. Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208(10):1963-76. [PubMed: 21875955]  [MGI Ref ID J:177573]

Viret C; Leung-Theung-Long S; Serre L; Lamare C; Vignali DA; Malissen B; Carrier A; Guerder S. 2011. Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice. J Clin Invest 121(5):1810-21. [PubMed: 21505262]  [MGI Ref ID J:173941]

Viriyakosol S; Matthias MA; Swancutt MA; Kirkland TN; Vinetz JM. 2006. Toll-like receptor 4 protects against lethal Leptospira interrogans serovar icterohaemorrhagiae infection and contributes to in vivo control of leptospiral burden. Infect Immun 74(2):887-95. [PubMed: 16428731]  [MGI Ref ID J:105019]

Volkmann A; Doffinger R; Ruther U; Kyewski BA. 1996. Insertional mutagenesis affecting programmed cell death leads to thymic hyperplasia and altered thymopoiesis. J Immunol 156(1):136-45. [PubMed: 8598454]  [MGI Ref ID J:108193]

Vujanovic L; Szymkowski DE; Alber S; Watkins SC; Vujanovic NL; Butterfield LH. 2010. Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15. Blood 116(4):575-83. [PubMed: 20430958]  [MGI Ref ID J:162797]

Waldner H; Sobel RA; Price N; Kuchroo VK. 2006. The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells. J Immunol 176(9):5455-62. [PubMed: 16622013]  [MGI Ref ID J:131655]

Walzer PD; Runck J; Steele P; White M; Linke MJ; Sidman CL. 1997. Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs. Antimicrob Agents Chemother 41(2):251-8. [PubMed: 9021175]  [MGI Ref ID J:39028]

Wang C; Bogue MA; Levitt JM; Roth DB. 1999. Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells. J Exp Med 190(9):1257-62. [PubMed: 10544197]  [MGI Ref ID J:115093]

Wang GY; So PL; Wang L; Libove E; Wang J; Epstein EH Jr. 2011. Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. J Invest Dermatol 131(11):2298-305. [PubMed: 21833014]  [MGI Ref ID J:182174]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang LX; Kang G; Kumar P; Lu W; Li Y; Zhou Y; Li Q; Wood C. 2014. Humanized-BLT mouse model of Kaposi's sarcoma-associated herpesvirus infection. Proc Natl Acad Sci U S A 111(8):3146-51. [PubMed: 24516154]  [MGI Ref ID J:206819]

Wang P; Rodriguez RT; Wang J; Ghodasara A; Kim SK. 2011. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell 8(3):335-46. [PubMed: 21362573]  [MGI Ref ID J:171124]

Wang Y; Sul HS. 2009. Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9. Cell Metab 9(3):287-302. [PubMed: 19254573]  [MGI Ref ID J:147095]

Warner T; Balish E. 1995. Pulmonary alveolar proteinosis. A spontaneous and inducible disease in immunodeficient germ-free mice. Am J Pathol 146(4):1017-24. [PubMed: 7717446]  [MGI Ref ID J:24415]

Wecker H; Grusby MJ; Auchincloss H Jr. 1995. Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation 59(8):1223-7. [PubMed: 7732570]  [MGI Ref ID J:25110]

Westwell-Roper C; Dai DL; Soukhatcheva G; Potter KJ; van Rooijen N; Ehses JA; Verchere CB. 2011. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 187(5):2755-65. [PubMed: 21813778]  [MGI Ref ID J:179268]

White RE; Ramer PC; Naresh KN; Meixlsperger S; Pinaud L; Rooney C; Savoldo B; Coutinho R; Bodor C; Gribben J; Ibrahim HA; Bower M; Nourse JP; Gandhi MK; Middeldorp J; Cader FZ; Murray P; Munz C; Allday MJ. 2012. EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J Clin Invest 122(4):1487-502. [PubMed: 22406538]  [MGI Ref ID J:184554]

Wicklein D; Schmidt A; Labitzky V; Ullrich S; Valent P; Schumacher U. 2013. E- and p-selectins are essential for repopulation of chronic myelogenous and chronic eosinophilic leukemias in a scid mouse xenograft model. PLoS One 8(7):e70139. [PubMed: 23922938]  [MGI Ref ID J:204363]

Wigginton JM; Lee JK; Wiltrout TA; Alvord WG; Hixon JA; Subleski J; Back TC; Wiltrout RH. 2002. Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169(8):4467-74. [PubMed: 12370382]  [MGI Ref ID J:109850]

Wilkison M; Gauss K; Ran Y; Searles S; Taylor D; Meissner N. 2012. Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection. Am J Pathol 181(1):151-62. [PubMed: 22626807]  [MGI Ref ID J:185537]

Willimann K; Matile H; Weiss NA; Imhof BA. 1995. In vivo sequestration of Plasmodium falciparum-infected human erythrocytes: a severe combined immunodeficiency mouse model for cerebral malaria. J Exp Med 182(3):643-53. [PubMed: 7650476]  [MGI Ref ID J:28277]

Winslow GM; Yager E; Shilo K; Collins DN; Chu FK. 1998. Infection of the laboratory mouse with the intracellular pathogen Ehrlichia chaffeensis. Infect Immun 66(8):3892-9. [PubMed: 9673277]  [MGI Ref ID J:48876]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204]  [MGI Ref ID J:109830]

Woods NB; Bottero V; Schmidt M; von Kalle C; Verma IM. 2006. Gene therapy: therapeutic gene causing lymphoma. Nature 440(7088):1123. [PubMed: 16641981]  [MGI Ref ID J:108380]

Wu T; Sun C; Chen Z; Zhen Y; Peng J; Qi Z; Yang X; Zhao Y. 2012. Smad3-deficient CD11b(+)Gr1(+) myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway. J Immunol 189(10):4989-5000. [PubMed: 23045614]  [MGI Ref ID J:190588]

Xu W; Xin L; Soong L; Zhang K. 2011. Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host. Infect Immun 79(8):3377-87. [PubMed: 21576322]  [MGI Ref ID J:175272]

XuFeng R; Boyer MJ; Shen H; Li Y; Yu H; Gao Y; Yang Q; Wang Q; Cheng T. 2009. ADAR1 is required for hematopoietic progenitor cell survival via RNA editing. Proc Natl Acad Sci U S A 106(42):17763-8. [PubMed: 19805087]  [MGI Ref ID J:153698]

Yahata T; Ando K; Nakamura Y; Ueyama Y; Shimamura K; Tamaoki N; Kato S; Hotta T. 2002. Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 169(1):204-9. [PubMed: 12077246]  [MGI Ref ID J:77239]

Yamasaki H; Sada A; Iwata T; Niwa T; Tomizawa M; Xanthopoulos KG; Koike T; Shiojiri N. 2006. Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development 133(21):4233-43. [PubMed: 17021047]  [MGI Ref ID J:114400]

Yamashita J; Iwamura C; Ito T; Narita M; Hara Y; Sasaki T; Masuda D; Takahashi M; Tsuchiya M; Hada K; Ishikawa M; Matsuo T; Ohno Y; Tanaka H; Maruyama H; Ogawa Y; Nakayama T. 2013. Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-gamma production from CD4 T cells. J Immunol 191(2):949-60. [PubMed: 23772025]  [MGI Ref ID J:204816]

Yan BS; Pichugin AV; Jobe O; Helming L; Eruslanov EB; Gutierrez-Pabello JA; Rojas M; Shebzukhov YV; Kobzik L; Kramnik I. 2007. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 179(10):6919-32. [PubMed: 17982083]  [MGI Ref ID J:154010]

Yang GX; Wu Y; Tsukamoto H; Leung PS; Lian ZX; Rainbow DB; Hunter KM; Morris GA; Lyons PA; Peterson LB; Wicker LS; Gershwin ME; Ridgway WM. 2011. CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J Immunol 186(2):1259-67. [PubMed: 21169553]  [MGI Ref ID J:168755]

Yang L; Chen G; Mohanty S; Scott G; Fazal F; Rahman A; Begum S; Hynes RO; Xu L. 2011. GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression. Cancer Res 71(16):5558-68. [PubMed: 21724588]  [MGI Ref ID J:175446]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y. 2013. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proc Natl Acad Sci U S A 110(34):13932-7. [PubMed: 23918367]  [MGI Ref ID J:200676]

Yang YG; Chen AM; Garrett LJ; Sergio JJ; Theodore P; Awwad M; VerHalen J; Bodine DM; Sachs DH; Sykes M. 2000. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation 7(1):58-64. [PubMed: 10809058]  [MGI Ref ID J:94302]

Yasuda A; Tsuji O; Shibata S; Nori S; Takano M; Kobayashi Y; Takahashi Y; Fujiyoshi K; Hara CM; Miyawaki A; Okano HJ; Toyama Y; Nakamura M; Okano H. 2011. Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord. Stem Cells 29(12):1983-94. [PubMed: 22028197]  [MGI Ref ID J:190194]

Yasutomo K; Maeda K; Hisaeda H; Good RA; Kuroda Y; Himeno K. 1997. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus. J Immunol 158(10):4729-33. [PubMed: 9144486]  [MGI Ref ID J:40207]

Yeh ES; Lew BO; Means AR. 2006. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem 281(1):241-51. [PubMed: 16223725]  [MGI Ref ID J:105781]

Yi S; Ji M; Wu J; Ma X; Phillips P; Hawthorne WJ; O'Connell PJ. 2012. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes 61(5):1180-91. [PubMed: 22403295]  [MGI Ref ID J:196728]

Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells. Eur J Immunol 42(8):2010-8. [PubMed: 22865049]  [MGI Ref ID J:187880]

Yoshida K; van den Berg TK; Dijkstra CD. 1994. The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of the lymphocytes. Eur J Immunol 24(2):464-8. [PubMed: 8299696]  [MGI Ref ID J:16866]

Yoshioka T; Otero J; Chen Y; Kim YM; Koutcher JA; Satagopan J; Reuter V; Carver B; de Stanchina E; Enomoto K; Greenberg NM; Scardino PT; Scher HI; Sawyers CL; Giancotti FG. 2013. beta4 Integrin signaling induces expansion of prostate tumor progenitors. J Clin Invest :. [PubMed: 23348745]  [MGI Ref ID J:194482]

Yoshizawa M; Okada T; Morikawa Y; Sasaki F; Kiso Y. 1994. Murine granulated metrial gland cell population in beige (bg/bg) and SCID (scid/scid) genotypes. J Vet Med Sci 56(2):415-6. [PubMed: 8075241]  [MGI Ref ID J:21177]

Young D; Kearney JF. 1995. Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice. Int Immunol 7(5):807-19. [PubMed: 7547707]  [MGI Ref ID J:25547]

Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. [PubMed: 15494484]  [MGI Ref ID J:132809]

Zane NA; Gundelach JH; Lindquist LD; Bram RJ. 2012. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol 188(7):3009-18. [PubMed: 22351938]  [MGI Ref ID J:183110]

Zare F; Bokarewa M; Nenonen N; Bergstrom T; Alexopoulou L; Flavell RA; Tarkowski A. 2004. Arthritogenic properties of double-stranded (viral) RNA. J Immunol 172(9):5656-63. [PubMed: 15100310]  [MGI Ref ID J:89689]

Zavidij O; Ball CR; Herbst F; Fessler S; Schmidt M; von Kalle C; Glimm H. 2010. Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation. Blood 115(24):5023-5. [PubMed: 20382848]  [MGI Ref ID J:161539]

Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 17(5):427-42. [PubMed: 20478526]  [MGI Ref ID J:160523]

Zhang C; Cui Y; Houston S; Chang LJ. 1996. Protective immunity to HIV-1 in SCID/beige mice reconstituted with peripheral blood lymphocytes of exposed but uninfected individuals. Proc Natl Acad Sci U S A 93(25):14720-5. [PubMed: 8962121]  [MGI Ref ID J:37253]

Zhang H; Zhou X; McQuade T; Li J; Chan FK; Zhang J. 2011. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471(7338):373-6. [PubMed: 21368761]  [MGI Ref ID J:170816]

Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200(11):1467-78. [PubMed: 15583018]  [MGI Ref ID J:94696]

Zhang S; Yajima H; Huynh H; Zheng J; Callen E; Chen HT; Wong N; Bunting S; Lin YF; Li M; Lee KJ; Story M; Gapud E; Sleckman BP; Nussenzweig A; Zhang CC; Chen DJ; Chen BP. 2011. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol 193(2):295-305. [PubMed: 21482716]  [MGI Ref ID J:171351]

Zhang X; Wan G; Mlotshwa S; Vance V; Berger FG; Chen H; Lu X. 2010. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res 70(18):7176-86. [PubMed: 20668064]  [MGI Ref ID J:164245]

Zhao Y; Guo C; Hwang D; Lin B; Dingeldein M; Mihailescu D; Sam S; Sidhwani S; Zhang Y; Jain S; Skidgel RA; Prabhakar BS; Mazzone T; Holterman MJ. 2010. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun 399(4):629-36. [PubMed: 20691153]  [MGI Ref ID J:164900]

Zheng CF; Guan KL. 1993. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J Biol Chem 268(15):11435-9. [PubMed: 8388392]  [MGI Ref ID J:31929]

Zheng M; Ramsay AJ; Robichaux MB; Norris KA; Kliment C; Crowe C; Rapaka RR; Steele C; McAllister F; Shellito JE; Marrero L; Schwarzenberger P; Zhong Q; Kolls JK. 2005. CD4+ T cell-independent DNA vaccination against opportunistic infections. J Clin Invest 115(12):3536-44. [PubMed: 16308571]  [MGI Ref ID J:104584]

Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165(10):5580-7. [PubMed: 11067913]  [MGI Ref ID J:119580]

Zhu C; Roth DB. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2(1):101-12. [PubMed: 7600297]  [MGI Ref ID J:28349]

de Laval B; Pawlikowska P; Petit-Cocault L; Bilhou-Nabera C; Aubin-Houzelstein G; Souyri M; Pouzoulet F; Gaudry M; Porteu F. 2013. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell 12(1):37-48. [PubMed: 23246483]  [MGI Ref ID J:194947]

de Oliveira VL; Keijsers RR; van de Kerkhof PC; Seyger MM; Fasse E; Svensson L; Latta M; Norsgaard H; Labuda T; Hupkens P; van Erp PE; Joosten I; Koenen HJ. 2012. Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells. PLoS One 7(10):e45509. [PubMed: 23094018]  [MGI Ref ID J:192181]

van Buul PP; Abramsson-Zetterberg L; Zandman IM; van Duyn-Goedhart A. 1998. Further characterization of the radiosensitivity of the scid mouse. Int J Radiat Biol 74(1):35-41. [PubMed: 9687973]  [MGI Ref ID J:115137]

van Essen D; Dullforce P; Gray D. 2000. Role of B cells in maintaining helper T-cell memory. Philos Trans R Soc Lond B Biol Sci 355(1395):351-5. [PubMed: 10794053]  [MGI Ref ID J:106317]

van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576]  [MGI Ref ID J:104292]

van den Pol AN. 2009. Brain trauma enhances transient cytomegalovirus invasion of the brain only in mice that are immunodeficient. J Virol 83(1):420-7. [PubMed: 18945784]  [MGI Ref ID J:153392]

van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. [PubMed: 23690475]  [MGI Ref ID J:204834]

von Herrath MG; Dockter J; Oldstone MB. 1994. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity 1(3):231-42. [PubMed: 7889411]  [MGI Ref ID J:81287]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred by crossing female mice that are heterozygous for the B2mtm1Unc allele and homozygous for the Prkdcscid allele, and homozygous for the X-linked Il2rgtm1Wjl allele to male mice that are homozygous for the B2mtm1Unc and Prkdcscid alleles and hemizygous for the X-linked Il2rgtm1Wjl allele.
Mating SystemSee Colony Maintenance under the Health & Care tab         (Female x Male)   20-JAN-10

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $125.00FemaleHeterozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl  
$125.00MaleHomozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  
Individual Mouse $125.00FemaleHomozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl  
Price per Pair (US dollars $)Pair Genotype
$250.00Heterozygous for B2m, Homozygous for Prkdc, Homozygous for Il2rg x Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  
$250.00Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl x Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $162.50FemaleHeterozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl  
$162.50MaleHomozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  
Individual Mouse $162.50FemaleHomozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl  
Price per Pair (US dollars $)Pair Genotype
$325.00Heterozygous for B2m, Homozygous for Prkdc, Homozygous for Il2rg x Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  
$325.00Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Homozygous for Il2rgtm1Wjl x Homozygous for B2mtm1Unc, Homozygous for Prkdcscid, Hemizygous for Il2rgtm1Wjl  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   001303 NOD.CB17-Prkdcscid/J
   005557 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Research institutions require an MTA, companies require a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.5)