Strain Name:

B6;129S1-Snai2tm2Grid/J

Stock Number:

010722

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Availability:

Cryopreserved - Ready for recovery

This Snai2del1 mutant mouse strain may be useful in studies of Waardenburg Syndrome, Type IID, pigmentation, gonadal development and hematopoiesis.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Generation?pN1
Generation Definitions
 
Donating Investigator Tom Gridley,   Maine Medical Center Research Institute

Description
Mice that are homozygous for the targeted mutation are viable, subfertile, and are smaller in size than wildtype controls. Homozygotes have diluted coat color and areas of depigmentation, sometimes exhibiting white forehead blaze and spots on tails and feet. From birth to weaning age (approximately 3 weeks), homozygotes exhibit slowed growth rate and by 3 weeks of age weigh approximately 70% of wildtype control. After weaning, mutant growth rates are similar to wildtype, but mutants remain small in size. Homozygous adults develop eye infections (suppurative conjunctivitis and blepharitis). Homozygous males have reduced testes size due to reduced seminiferous tubules and are slightly subfertile, producing smaller litters sizes. Approximately 15% of homozygous males are infertile. Spermatogenesis is normal, however, in fertile homozygotes. Homozygotes exhibit macrocytic anemia, decreased hematocrit and leukocyte numbers. T cell differentiation is impaired and thymus size is diminished. Some mutant mice display hyperactivity and circling behavior.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt the entire protein coding region of the gene. The construct was electroporated into 129S1/Sv-Oca2+ Tyr+ Kitl+ derived CJ7 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice. The mice were backcrossed to C57BL/6J once to establish the colony.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Facebase: models
007664   129S-Efnb1tm1Sor/J
000646   A/J
000647   A/WySnJ
005709   B6.129-Skitm1Cco/J
002619   B6.129-Tgfb3tm1Doe/J
007453   B6.129P2(Cg)-Dhcr7tm1Gst/J
010525   B6.129S-Notch2tm3Grid/J
010616   B6.129S1-Jag1tm1Grid/J
010546   B6.129S1-Jag2tm1Grid/J
010620   B6.129S1-Notch2tm1Grid/J
009387   B6.129S1-Osr1tm1Jian/J
009386   B6.129S1-Osr2tm1Jian/J
010621   B6.129S1-Snai1tm2.1Grid/J
010617   B6.129S1-Snai2tm1Grid/J
003865   B6.129S2-Itgavtm1Hyn/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
016902   B6.129S5-Irf6Gt(OST398253)Lex/J
003336   B6.129S7-Cdkn1ctm1Sje/J
012843   B6.129X1(Cg)-Slc32a1tm1.1Bgc/J
000026   B6.C3-Gli3Xt-J/J
004275   B6.Cg-Fignfi/Frk
012844   B6.Cg-Gad1tm1.1Bgc/J
006382   B6;129-Casktm1Sud/J
002711   B6;129-Gabrb3tm1Geh/J
004293   B6;129-Shhtm2Amc/J
012603   B6;129-Tgfbr2tm1Karl/J
010618   B6;129S-Jag1tm2Grid/J
010686   B6;129S-Snai1tm2Grid/J
009389   B6;129S1-Bambitm1Jian/J
010619   B6;129S1-Lfngtm1Grid/J
010547   B6;129S1-Notch3tm1Grid/J
010544   B6;129S1-Notch4tm1Grid/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
022358   B6;129S6-Rr23tm1Axvi/Mmjax
022359   B6;129S6-Rr24tm1Axvi/Mmjax
022360   B6;129S6-Rr25tm1Axvi/Mmjax
003277   B6;129S7-Acvr2atm1Zuk/J
002788   B6;129S7-Fsttm1Zuk/J
002990   B6;129S7-Inhbatm1Zuk/J
000523   B6By.Cg-Eh/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000515   B6CBACa Aw-J/A-SfnEr/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
000252   DC/LeJ
005057   FVB.129-Kcnj2tm1Swz/J
012655   FVB.A-Irf6clft1/BeiJ
013100   FVB.C-Prdm16csp1/J
017437   FVB/N-Ckap5TgTn(sb-cHS4,Tyr)2320F-1Ove/J
017438   FVB/N-MidnTg(Tyr)2261EOve/J
017609   FVB/N-Rr16Tn(sb-Tyr)1HCebOve/J
017598   FVB/N-Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove/J
017608   FVB/N-Skor2Tn(sb-Tyr)1799B.CA7BOve/J
017436   FVB/N-Tapt1TgTn(sb-cHS4,Tyr)2508GOve/J
016870   FVB/NJ-Ap2b1Tg(Tyr)427Ove/EtevJ
017434   FVB;B6-Cramp1lTgTn(sb-rtTA,Tyr)2447AOve/J
017594   FVB;B6-Eya4TgTn(Prm1-sb10,sb-Tyr)1739AOve/J
017435   FVB;B6-SlmapTn(sb-rtTA)2426B.SB4Ove/J
003318   STOCK Shhtm1Amc/J
003102   STOCK Tgfb2tm1Doe/J
018624   STOCK Tgfb3tm2(Tgfb1)Vk/J
008469   STOCK Wnt9btm1.2Amc/J
View Facebase: models     (61 strains)

Strains carrying other alleles of Snai2
010617   B6.129S1-Snai2tm1Grid/J
View Strains carrying other alleles of Snai2     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Waardenburg Syndrome, Type 2D; WS2D
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Piebald Trait; PBT   (SNAI2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Snai2tm2Grid/Snai2tm2Grid

        involves: 129S1/Sv * C57BL/6
  • mortality/aging
  • complete neonatal lethality
    • homozygotes with cleft palate die shortly after birth   (MGI Ref ID J:121243)
  • craniofacial phenotype
  • cleft secondary palate
    • ~50% of homozygotes display cleft secondary palate   (MGI Ref ID J:121243)
    • persistence of medial edge epithelium during palatal shelf fusion
      • at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse   (MGI Ref ID J:121243)
  • digestive/alimentary phenotype
  • cleft secondary palate
    • ~50% of homozygotes display cleft secondary palate   (MGI Ref ID J:121243)
    • persistence of medial edge epithelium during palatal shelf fusion
      • at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse   (MGI Ref ID J:121243)
  • growth/size/body phenotype
  • cleft secondary palate
    • ~50% of homozygotes display cleft secondary palate   (MGI Ref ID J:121243)
    • persistence of medial edge epithelium during palatal shelf fusion
      • at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse   (MGI Ref ID J:121243)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Snai2tm2Grid/Snai2tm2Grid

        involves: 129S1/Sv
  • pigmentation phenotype
  • abnormal skin pigmentation
    • various degrees of dermal depigmentation; tails and feet are often depigmented   (MGI Ref ID J:78323)
  • diluted coat color   (MGI Ref ID J:78323)
  • head blaze
    • white forehead blaze occasionally noted   (MGI Ref ID J:78323)
  • variable body spotting
    • occasional white spotting of coat   (MGI Ref ID J:78323)
    • mutants exhibit areas of hypopigmentation on the midforehead and extremity depigmentation   (MGI Ref ID J:80529)
  • behavior/neurological phenotype
  • circling   (MGI Ref ID J:80529)
    • genetic background effects were noted, but not specified   (MGI Ref ID J:78323)
  • hyperactivity   (MGI Ref ID J:80529)
    • genetic background effects were noted, but not specified   (MGI Ref ID J:78323)
  • endocrine/exocrine gland phenotype
  • small seminiferous tubules
    • despite the reduced size of the tubules, spermatogenesis appeared normal   (MGI Ref ID J:78323)
  • small testis
    • testes were reduced by 40% compared to controls   (MGI Ref ID J:78323)
  • small thymus
    • apoptotic cells were noted in the cortical level   (MGI Ref ID J:78323)
  • growth/size/body phenotype
  • decreased body size
    • at time of weaning animals weighed 70% that of wild-type and heterozygous littermates   (MGI Ref ID J:48521)
  • postnatal growth retardation
    • animals showed moderate growth retardation during the first 3 weeks of life   (MGI Ref ID J:48521)
    • after weaning, growth rate matches that of wild-type but animals never attain wild-type body size   (MGI Ref ID J:48521)
  • hematopoietic system phenotype
  • abnormal T cell differentiation
    • a partial block in T cell differentiation in the thymus resulted in fewer mature CD4+/CD8+ cells   (MGI Ref ID J:78323)
  • decreased hematocrit   (MGI Ref ID J:78323)
  • decreased hemoglobin content   (MGI Ref ID J:78323)
  • decreased leukocyte cell number   (MGI Ref ID J:78323)
  • decreased platelet cell number   (MGI Ref ID J:78323)
  • increased mean corpuscular volume   (MGI Ref ID J:78323)
  • macrocytic anemia   (MGI Ref ID J:78323)
  • small thymus
    • apoptotic cells were noted in the cortical level   (MGI Ref ID J:78323)
  • immune system phenotype
  • abnormal T cell differentiation
    • a partial block in T cell differentiation in the thymus resulted in fewer mature CD4+/CD8+ cells   (MGI Ref ID J:78323)
  • blepharitis
    • variable degrees of inflammation; almost all homozygotes develop swollen eyelids   (MGI Ref ID J:48521)
  • conjunctivitis
    • variable degrees of neutrophilic infiltration   (MGI Ref ID J:48521)
  • decreased leukocyte cell number   (MGI Ref ID J:78323)
  • small thymus
    • apoptotic cells were noted in the cortical level   (MGI Ref ID J:78323)
  • reproductive system phenotype
  • decreased litter size
    • small litters from homozygous males were produced; on average the litter size was 3-6 pups vs. 10-12 in controls   (MGI Ref ID J:78323)
  • male infertility
    • incomplete penetrance; 15% of males fail to induce pregnancy despite producing plugs in females   (MGI Ref ID J:78323)
  • reduced male fertility
    • small litters from homozygous males were produced; on average the litter size was 3-6 pups vs. 10-12 in controls   (MGI Ref ID J:78323)
  • small seminiferous tubules
    • despite the reduced size of the tubules, spermatogenesis appeared normal   (MGI Ref ID J:78323)
  • small testis
    • testes were reduced by 40% compared to controls   (MGI Ref ID J:78323)
  • vision/eye phenotype
  • abnormal conjunctiva morphology
    • histological analysis revealed a number of conjunctival abnormalities   (MGI Ref ID J:48521)
    • conjunctivitis
      • variable degrees of neutrophilic infiltration   (MGI Ref ID J:48521)
  • blepharitis
    • variable degrees of inflammation; almost all homozygotes develop swollen eyelids   (MGI Ref ID J:48521)
  • integument phenotype
  • abnormal skin pigmentation
    • various degrees of dermal depigmentation; tails and feet are often depigmented   (MGI Ref ID J:78323)
  • diluted coat color   (MGI Ref ID J:78323)
  • head blaze
    • white forehead blaze occasionally noted   (MGI Ref ID J:78323)
  • variable body spotting
    • occasional white spotting of coat   (MGI Ref ID J:78323)
    • mutants exhibit areas of hypopigmentation on the midforehead and extremity depigmentation   (MGI Ref ID J:80529)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Internal/Organ Defects
      gonads
      hematopoietic defects

Hematological Research
Hematopoietic Defects

Internal/Organ Research
Thymus Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      males only

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Snai2tm2Grid
Allele Name targeted mutation 2, Tom Gridley
Allele Type Targeted (Null/Knockout)
Common Name(s) Slug-; Slughdelta1; Snai2del1;
Mutation Made By Tom Gridley,   Maine Medical Center Research Institute
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Gene Symbol and Name Snai2, snail family zinc finger 2
Chromosome 16
Gene Common Name(s) SLUG; SLUGH1; SNAIL2; Slugh; WS2D; slug, chicken homolog;
Molecular Note The gene was inactivated by replacement of the entire protein coding region with a PGK-neo cassette via homologous recombination. [MGI Ref ID J:48521]

Genotyping

Genotyping Information

Genotyping Protocols

Snai2tm2Grid,

Separated MCA


Snai2tm2Grid, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Jiang R; Lan Y; Norton CR; Sundberg JP; Gridley T. 1998. The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol 198(2):277-85. [PubMed: 9659933]  [MGI Ref ID J:48521]

Additional References

Snai2tm2Grid related

Murray SA; Gridley T. 2006. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A 103(27):10300-4. [PubMed: 16801545]  [MGI Ref ID J:111702]

Murray SA; Oram KF; Gridley T. 2007. Multiple functions of Snail family genes during palate development in mice. Development 134(9):1789-97. [PubMed: 17376812]  [MGI Ref ID J:121243]

Oram KF; Gridley T. 2005. Mutations in Snail Family Genes Enhance Craniosynostosis of Twist1 Haplo-insufficient Mice: Implications for Saethre-Chotzen Syndrome. Genetics 170(2):971-4. [PubMed: 15802514]  [MGI Ref ID J:99331]

Perez-Caro M; Bermejo-Rodriguez C; Gonzalez-Herrero I; Sanchez-Beato M; Piris MA; Sanchez-Garcia I. 2008. Transcriptomal profiling of the cellular response to DNA damage mediated by Slug (Snai2). Br J Cancer 98(2):480-8. [PubMed: 18182996]  [MGI Ref ID J:134194]

Perez-Losada J; Sanchez-Martin M; Rodriguez-Garcia A; Sanchez ML; Orfao A; Flores T; Sanchez-Garcia I. 2002. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 100(4):1274-86. [PubMed: 12149208]  [MGI Ref ID J:78323]

Perez-Mancera PA; Bermejo-Rodriguez C; Gonzalez-Herrero I; Herranz M; Flores T; Jimenez R; Sanchez-Garcia I. 2007. Adipose tissue mass is modulated by SLUG (SNAI2). Hum Mol Genet 16(23):2972-86. [PubMed: 17905753]  [MGI Ref ID J:130039]

Perez-Mancera PA; Gonzalez-Herrero I; Maclean K; Turner AM; Yip MY; Sanchez-Martin M; Garcia JL; Robledo C; Flores T; Gutierrez-Adan A; Pintado B; Sanchez-Garcia I. 2006. SLUG (SNAI2) overexpression in embryonic development. Cytogenet Genome Res 114(1):24-9. [PubMed: 16717446]  [MGI Ref ID J:109188]

Perez-Mancera PA; Gonzalez-Herrero I; Perez-Caro M; Gutierrez-Cianca N; Flores T; Gutierrez-Adan A; Pintado B; Sanchez-Martin M; Sanchez-Garcia I. 2005. SLUG in cancer development. Oncogene 24(19):3073-82. [PubMed: 15735690]  [MGI Ref ID J:98295]

Sanchez-Martin M; Rodriguez-Garcia A; Perez-Losada J; Sagrera A; Read AP; Sanchez-Garcia I. 2002. SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11(25):3231-6. [PubMed: 12444107]  [MGI Ref ID J:80529]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as heterozygotes. Homozygotes are subfertile.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use


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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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