Strain Name:



Repository- Live     Available at the JAX MMRRC

Use Restrictions Apply, see Terms of Use
Common Names: IFN-αβR-;    
Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for information about B6.129S2-Ifnar1tm1Agt/Mmjax MMRRC Stock Number 032045.
Homozygotes are more susceptible to viral infection, have an abnormal NK antitumor response, and reduced bone mass. This mutant mouse strain may be useful in studies of immunological response to infection, and bone homeostasis.


Strain Information

Type Congenic; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   16-JUN-14
Specieslaboratory mouse
GenerationN6+F15 (06-MAY-15)
Generation Definitions
Donating InvestigatorDr. Michel Aguet,   EPFL, École polytechnique fédérale de Lausanne

Mice that are homozygous for the targeted mutation are viable, fertile, and normal in size. No gene product (mRNA) is detected by Northern blot analysis of homozygous primary embryonic fibroblasts. Mice that are homozygous for this targeted allele lack type I IFN receptor function, exhibit enhanced osteoclastogenesis with decreased bone density, and impaired response to protozoan parasite (Leishmania) infection. NK cell mediated tumor regression does not occur in homozygotes in response to B16 melanoma tumor implant model.

A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt exon 3. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The mice were backcrossed to C57Bl/6 for at least 5 generations, as reported by the donating investigator.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype


  • immune system phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • abnormal response to infection
    • murine cytomegalovirus replication in macrophages is increased greater than 10,000-fold compared to that in wild-type macrophages   (MGI Ref ID J:116703)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • all mice treated with LPS die unlike control mice   (MGI Ref ID J:199862)
  • decreased interferon-alpha secretion
    • following infection with Leishmania   (MGI Ref ID J:125611)
  • decreased interferon-beta secretion
    • following infection with Leishmania   (MGI Ref ID J:125611)
  • decreased interleukin-6 secretion
    • from bone marrow-derived macrophage stimulated with LPS or E. coli K1 E-R8   (MGI Ref ID J:199862)
  • decreased tumor necrosis factor secretion
    • from bone marrow-derived macrophage stimulated with LPS or E. coli K1 E-R8   (MGI Ref ID J:199862)
  • impaired natural killer cell mediated cytotoxicity
    • natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells   (MGI Ref ID J:118750)
  • tumorigenesis
  • increased tumor growth/size
    • in mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice   (MGI Ref ID J:118750)
  • hematopoietic system phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • impaired natural killer cell mediated cytotoxicity
    • natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells   (MGI Ref ID J:118750)
  • skeleton phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • decreased bone mineral density   (MGI Ref ID J:76097)
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice treated with LPS die unlike control mice   (MGI Ref ID J:199862)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S2/SvPas
  • mortality/aging
  • increased susceptibility to viral infection induced morbidity/mortality
    • MCMV-treated mice exhibit a 800-fold lower LD50 compared with similarly treated wild-type mice   (MGI Ref ID J:115139)
  • immune system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
    • there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
  • abnormal cytokine secretion
    • upon viral infection, interferon alpha induction is normal initially, but in later phases does not reach wild-type levels   (MGI Ref ID J:114555)
  • abnormal dendritic cell physiology
    • in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed   (MGI Ref ID J:114555)
    • Ifn beta stimulation of dendritic cells elicits a significantly lower response in mutant cells than in wild-type   (MGI Ref ID J:114555)
    • amplification of dendritic signaling is suppressed in mutant dendritic cells stimulated with poly(I:C); RelA activation is suppressed   (MGI Ref ID J:114555)
    • induction of MHC and costimulatory molecules is abolished in dendritic cells upon infection with Newcastle disease virus (NDC)   (MGI Ref ID J:114555)
    • maturation of dendritic cells is impaired when stimulated by poly(I:C), LPS or NDV, but migration in T cell zone of spleen is not affected   (MGI Ref ID J:114555)
    • stimulatory activity of CD4+ and CD8+ T cells by poly(I:C) is impaired in poly(I:C)-stimulated mutant dendritic cells; stimulatory activity of CD8+ T cells is impaired in the LPS- or CpG-stimulated dendritic cells to a lesser extent than in poly(I:C)-stimulated cells   (MGI Ref ID J:114555)
  • abnormal immunoglobulin level
    • levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus   (MGI Ref ID J:101427)
  • abnormal inflammatory response
    • in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed   (MGI Ref ID J:114555)
    • MHC I induction is severely impaired in response to all three stimuli   (MGI Ref ID J:114555)
  • increased susceptibility to viral infection
    • mice are 100-fold more susceptible to MCMV viral infection than controls   (MGI Ref ID J:81243)
    • increased susceptibility of encephalomyocarditis virus induced lethality   (MGI Ref ID J:137522)
    • increased susceptibility to Ectromelia virus   (MGI Ref ID J:101427)
    • 100% mortality by day 6-12 after primary infection infection   (MGI Ref ID J:101427)
    • elevated virus titers in all organs tested after primary infection but much improved after secondary infections   (MGI Ref ID J:101427)
    • survive secondary infections   (MGI Ref ID J:101427)
    • mice infected with HSV-2 strain 186 exhibit more severe clinical scores of disease (genital lesions, redness and swelling) compared with wild-type mice   (MGI Ref ID J:197569)
    • increased susceptibility to viral infection induced morbidity/mortality
      • MCMV-treated mice exhibit a 800-fold lower LD50 compared with similarly treated wild-type mice   (MGI Ref ID J:115139)
  • vision/eye phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • cardiovascular system phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
    • there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
  • abnormal immunoglobulin level
    • levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus   (MGI Ref ID J:101427)


        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • altered susceptibility to infection
    • infection with hvPR8 produces high titers of 5x107   (MGI Ref ID J:120938)
    • infection with lvPR8 produces low titers of 5x104   (MGI Ref ID J:120938)


        involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
  • immune system phenotype
  • increased susceptibility to viral infection
    • mice infected with Thogoto virus all succumb within 3 days compared to 5 days for littermate controls   (MGI Ref ID J:119783)


        involves: 129S2/SvPas * 129S6/SvEvTac
  • immune system phenotype
  • abnormal CD8-positive, alpha-beta T cell physiology
    • the antigen specificity of CD8 T cells to common LCMV-derived peptides differs from controls with a higher percentage being specific for the GP33-41 peptide   (MGI Ref ID J:54482)
  • abnormal interferon-gamma secretion
    • splenic leukocyte production of IFN-gamma is increased 3-fold 8 days after infection with LCMV compared to controls   (MGI Ref ID J:54482)
    • two-thirds of this IFN-gamma production is dependent on CD8 T cells   (MGI Ref ID J:54482)
    • these T cells produce less IFN-gamma on a per cell basis   (MGI Ref ID J:54482)
  • increased circulating interleukin-12 level
    • 3-4 pg/ml of IL-12 heterodimer are present in the serum 1.5- and 3- days after infection with LCMV while no IL-12 is detected at this timepoint in wild-type mice   (MGI Ref ID J:54482)
  • increased susceptibility to viral infection
    • mice have a 2-log higher viral titer in the spleen, and a 4-log higher viral titer in the liver, 4.5 days after infection with LCMV virus   (MGI Ref ID J:54482)
    • mice took much longer to clear virus, around 28 days, compared to 7 days for wild-type mice   (MGI Ref ID J:54482)
  • homeostasis/metabolism phenotype
  • increased circulating interleukin-12 level
    • 3-4 pg/ml of IL-12 heterodimer are present in the serum 1.5- and 3- days after infection with LCMV while no IL-12 is detected at this timepoint in wild-type mice   (MGI Ref ID J:54482)
  • hematopoietic system phenotype
  • abnormal CD8-positive, alpha-beta T cell physiology
    • the antigen specificity of CD8 T cells to common LCMV-derived peptides differs from controls with a higher percentage being specific for the GP33-41 peptide   (MGI Ref ID J:54482)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Research Tools
Cancer Research
      tumor immunology
Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Ifnar1tm1Agt
Allele Name targeted mutation 1, Michel Aguet
Allele Type Targeted (Null/Knockout)
Common Name(s) A 129; A129; A-; IFN Alpha Ro/o; IFN type I receptor; IFN-IR KO; IFN-IR-; IFN-alpha/betaR-; IFN-alpha/betaR/A129; IFN-alpha/betaR0; IFN-alphabeta-R KO; IFN-alphabetaR-; IFNAR(0); IFNAR-; IFNR-; IFNRA1,-.; IFNRI -; IFNRI KO; Ifnar1-;
Mutation Made ByDr. Michel Aguet,   EPFL, École polytechnique fédérale de Lausanne
Strain of Origin129S2/SvPas
Gene Symbol and Name Ifnar1, interferon (alpha and beta) receptor 1
Chromosome 16
Gene Common Name(s) AVP; IFN-alpha-REC; IFN-alpha/betaR; IFNAR; IFNBR; IFRC; Ifar; Ifrc;
Molecular Note A neomycin cassette was inserted into exon 3 at a position corresponding to amino acid 88. [MGI Ref ID J:36115] [MGI Ref ID J:96036]


Genotyping Information

Genotyping Protocols

Ifnar1tm1Agt, MELT
Ifnar1tm1Agt, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Muller U; Steinhoff U; Reis LF; Hemmi S; Pavlovic J; Zinkernagel RM; Aguet M. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264(5167):1918-21. [PubMed: 8009221]  [MGI Ref ID J:36115]

Additional References

Ifnar1tm1Agt related

Abbas K; Breton J; Picot CR; Quesniaux V; Bouton C; Drapier JC. 2009. Signaling events leading to peroxiredoxin 5 up-regulation in immunostimulated macrophages. Free Radic Biol Med 47(6):794-802. [PubMed: 19540914]  [MGI Ref ID J:152566]

Abe Y; Fujii K; Nagata N; Takeuchi O; Akira S; Oshiumi H; Matsumoto M; Seya T; Koike S. 2012. The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice. J Virol 86(1):185-94. [PubMed: 22072781]  [MGI Ref ID J:178834]

Abril C; Engels M; Liman A; Hilbe M; Albini S; Franchini M; Suter M; Ackermann M. 2004. Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice. J Virol 78(7):3644-53. [PubMed: 15016885]  [MGI Ref ID J:89073]

Agrawal H; Jacob N; Carreras E; Bajana S; Putterman C; Turner S; Neas B; Mathian A; Koss MN; Stohl W; Kovats S; Jacob CO. 2009. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 183(9):6021-9. [PubMed: 19812195]  [MGI Ref ID J:156625]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Aichele P; Unsoeld H; Koschella M; Schweier O; Kalinke U; Vucikuja S. 2006. CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J Immunol 176(8):4525-9. [PubMed: 16585541]  [MGI Ref ID J:131168]

Akazawa T; Ebihara T; Okuno M; Okuda Y; Shingai M; Tsujimura K; Takahashi T; Ikawa M; Okabe M; Inoue N; Okamoto-Tanaka M; Ishizaki H; Miyoshi J; Matsumoto M; Seya T. 2007. Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A 104(1):252-7. [PubMed: 17190817]  [MGI Ref ID J:118750]

Alazawi W; Heath H; Waters JA; Woodfin A; O'Brien AJ; Scarzello AJ; Ma B; Lopez-Otalora Y; Jacobs M; Petts G; Goldin RD; Nourshargh S; Gamero AM; Foster GR. 2013. Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis. Proc Natl Acad Sci U S A 110(21):8656-61. [PubMed: 23653476]  [MGI Ref ID J:197445]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Althof N; Harkins S; Kemball CC; Flynn CT; Alirezaei M; Whitton JL. 2014. In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease. J Virol 88(9):5087-99. [PubMed: 24574394]  [MGI Ref ID J:214430]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Ank N; Iversen MB; Bartholdy C; Staeheli P; Hartmann R; Jensen UB; Dagnaes-Hansen F; Thomsen AR; Chen Z; Haugen H; Klucher K; Paludan SR. 2008. An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 180(4):2474-85. [PubMed: 18250457]  [MGI Ref ID J:131989]

Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10):6044-50. [PubMed: 19414755]  [MGI Ref ID J:148244]

Arnold CN; Pirie E; Dosenovic P; McInerney GM; Xia Y; Wang N; Li X; Siggs OM; Karlsson Hedestam GB; Beutler B. 2012. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A :. [PubMed: 22761313]  [MGI Ref ID J:185495]

Asselin-Paturel C; Brizard G; Pin JJ; Briere F; Trinchieri G. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 171(12):6466-77. [PubMed: 14662846]  [MGI Ref ID J:86925]

Auerbuch V; Brockstedt DG; Meyer-Morse N; O'Riordan M; Portnoy DA. 2004. Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med 200(4):527-33. [PubMed: 15302899]  [MGI Ref ID J:93932]

Baban B; Chandler PR; Sharma MD; Pihkala J; Koni PA; Munn DH; Mellor AL. 2009. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 183(4):2475-83. [PubMed: 19635913]  [MGI Ref ID J:151475]

Baccala R; Welch MJ; Gonzalez-Quintial R; Walsh KB; Teijaro JR; Nguyen A; Ng CT; Sullivan BM; Zarpellon A; Ruggeri ZM; de la Torre JC; Theofilopoulos AN; Oldstone MB. 2014. Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci U S A 111(24):8925-30. [PubMed: 24889626]  [MGI Ref ID J:211634]

Baenziger S; Heikenwalder M; Johansen P; Schlaepfer E; Hofer U; Miller RC; Diemand S; Honda K; Kundig TM; Aguzzi A; Speck RF. 2009. Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood 113(2):377-88. [PubMed: 18824599]  [MGI Ref ID J:144246]

Bahl K; Kim SK; Calcagno C; Ghersi D; Puzone R; Celada F; Selin LK; Welsh RM. 2006. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 176(7):4284-95. [PubMed: 16547266]  [MGI Ref ID J:129873]

Bald T; Landsberg J; Lopez-Ramos D; Renn M; Glodde N; Jansen P; Gaffal E; Steitz J; Tolba R; Kalinke U; Limmer A; Jonsson G; Holzel M; Tuting T. 2014. Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov 4(6):674-87. [PubMed: 24589924]  [MGI Ref ID J:213428]

Ball EA; Sambo MR; Martins M; Trovoada MJ; Benchimol C; Costa J; Antunes Goncalves L; Coutinho A; Penha-Goncalves C. 2013. IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. J Immunol 190(10):5118-27. [PubMed: 23585679]  [MGI Ref ID J:202560]

Banks TA; Rickert S; Benedict CA; Ma L; Ko M; Meier J; Ha W; Schneider K; Granger SW; Turovskaya O; Elewaut D; Otero D; French AR; Henry SC; Hamilton JD; Scheu S; Pfeffer K; Ware CF. 2005. A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol 174(11):7217-25. [PubMed: 15905567]  [MGI Ref ID J:99001]

Barkhouse DA; Garcia SA; Bongiorno EK; Lebrun A; Faber M; Hooper DC. 2015. Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon. J Virol 89(1):312-22. [PubMed: 25320312]  [MGI Ref ID J:221392]

Baron ML; Gauchat D; La Motte-Mohs R; Kettaf N; Abdallah A; Michiels T; Zuniga-Pflucker JC; Sekaly RP. 2008. TLR Ligand-Induced Type I IFNs Affect Thymopoiesis. J Immunol 180(11):7134-46. [PubMed: 18490712]  [MGI Ref ID J:136351]

Barton ES; Lutzke ML; Rochford R; Virgin HW 4th. 2005. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol 79(22):14149-60. [PubMed: 16254350]  [MGI Ref ID J:102489]

Behrendt R; Schumann T; Gerbaulet A; Nguyen LA; Schubert N; Alexopoulou D; Berka U; Lienenklaus S; Peschke K; Gibbert K; Wittmann S; Lindemann D; Weiss S; Dahl A; Naumann R; Dittmer U; Kim B; Mueller W; Gramberg T; Roers A. 2013. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep 4(4):689-96. [PubMed: 23972988]  [MGI Ref ID J:202757]

Belhocine K; Monack DM. 2012. Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells. Cell Microbiol 14(1):71-80. [PubMed: 21902795]  [MGI Ref ID J:181382]

Biondo C; Midiri A; Gambuzza M; Gerace E; Falduto M; Galbo R; Bellantoni A; Beninati C; Teti G; Leanderson T; Mancuso G. 2008. IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis. J Immunol 181(1):566-73. [PubMed: 18566423]  [MGI Ref ID J:137360]

Birkner K; Steiner B; Rinkler C; Kern Y; Aichele P; Bogdan C; von Loewenich FD. 2008. The elimination of Anaplasma phagocytophilum requires CD4(+) T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38(12):3395-3410. [PubMed: 19039769]  [MGI Ref ID J:141369]

Biswas SK; Bist P; Dhillon MK; Kajiji T; Del Fresno C; Yamamoto M; Lopez-Collazo E; Akira S; Tergaonkar V. 2007. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. J Immunol 179(6):4083-92. [PubMed: 17785847]  [MGI Ref ID J:152028]

Blaauboer SM; Gabrielle VD; Jin L. 2014. MPYS/STING-mediated TNF-alpha, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol 192(1):492-502. [PubMed: 24307739]  [MGI Ref ID J:207163]

Blasius AL; Giurisato E; Cella M; Schreiber RD; Shaw AS; Colonna M. 2006. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 177(5):3260-5. [PubMed: 16920966]  [MGI Ref ID J:139501]

Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299]  [MGI Ref ID J:137877]

Bode KA; Schroder K; Hume DA; Ravasi T; Heeg K; Sweet MJ; Dalpke AH. 2007. Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122(4):596-606. [PubMed: 17635610]  [MGI Ref ID J:134422]

Bohnet SG; Traynor TR; Majde JA; Kacsoh B; Krueger JM. 2004. Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic hypocretin, prolactin and 2',5'-oligoadenylate synthetase expression. Brain Res 1027(1-2):117-25. [PubMed: 15494163]  [MGI Ref ID J:93528]

Borrow P; Hou S; Gloster S; Ashton M; Hyland L. 2005. Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalpha. Eur J Immunol 35(2):524-32. [PubMed: 15657949]  [MGI Ref ID J:95618]

Bosmann M; Strobl B; Kichler N; Rigler D; Grailer JJ; Pache F; Murray PJ; Muller M; Ward PA. 2014. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96(1):123-31. [PubMed: 24604832]  [MGI Ref ID J:212012]

Bouchlaka MN; Sckisel GD; Chen M; Mirsoian A; Zamora AE; Maverakis E; Wilkins DE; Alderson KL; Hsiao HH; Weiss JM; Monjazeb AM; Hesdorffer C; Ferrucci L; Longo DL; Blazar BR; Wiltrout RH; Redelman D; Taub DD; Murphy WJ. 2013. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med 210(11):2223-37. [PubMed: 24081947]  [MGI Ref ID J:204052]

Bourgeois C; Majer O; Frohner IE; Lesiak-Markowicz I; Hildering KS; Glaser W; Stockinger S; Decker T; Akira S; Muller M; Kuchler K. 2011. Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-{beta} Signaling. J Immunol 186(5):3104-12. [PubMed: 21282509]  [MGI Ref ID J:169378]

Boyd A; Fazakerley JK; Bridgen A. 2006. Pathogenesis of Dugbe virus infection in wild-type and interferon-deficient mice. J Gen Virol 87(Pt 7):2005-9. [PubMed: 16760403]  [MGI Ref ID J:129291]

Boyman O; Hefti HP; Conrad C; Nickoloff BJ; Suter M; Nestle FO. 2004. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med 199(5):731-6. [PubMed: 14981113]  [MGI Ref ID J:90470]

Braun D; Caramalho I; Demengeot J. 2002. IFN-alpha/beta enhances BCR-dependent B cell responses. Int Immunol 14(4):411-9. [PubMed: 11934877]  [MGI Ref ID J:113519]

Braun D; Geraldes P; Demengeot J. 2003. Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 20(1):15-25. [PubMed: 12604309]  [MGI Ref ID J:82338]

Bray M. 2001. The role of the Type I interferon response in the resistance of mice to filovirus infection. J Gen Virol 82(Pt 6):1365-73. [PubMed: 11369881]  [MGI Ref ID J:103240]

Brien JD; Uhrlaub JL; Hirsch A; Wiley CA; Nikolich-Zugich J. 2009. Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med 206(12):2735-45. [PubMed: 19901080]  [MGI Ref ID J:155455]

Bryant-Hudson KM; Chucair-Elliott AJ; Conrady CD; Cohen A; Zheng M; Carr DJ. 2013. HSV-1 Targets Lymphatic Vessels in the Eye and Draining Lymph Node of Mice Leading to Edema in the Absence of a Functional Type I Interferon Response. Am J Pathol 183(4):1233-42. [PubMed: 23911821]  [MGI Ref ID J:201901]

Brzoza-Lewis KL; Hoth JJ; Hiltbold EM. 2012. Type I interferon signaling regulates the composition of inflammatory infiltrates upon infection with Listeria monocytogenes. Cell Immunol 273(1):41-51. [PubMed: 22212606]  [MGI Ref ID J:181365]

Calvo-Pinilla E; Rodriguez-Calvo T; Anguita J; Sevilla N; Ortego J. 2009. Establishment of a bluetongue virus infection model in mice that are deficient in the alpha/beta interferon receptor. PLoS ONE 4(4):e5171. [PubMed: 19357779]  [MGI Ref ID J:148164]

Carnevalli LS; Scognamiglio R; Cabezas-Wallscheid N; Rahmig S; Laurenti E; Masuda K; Jockel L; Kuck A; Sujer S; Polykratis A; Erlacher M; Pasparakis M; Essers MA; Trumpp A. 2014. Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med 211(5):769-79. [PubMed: 24752302]  [MGI Ref ID J:211304]

Carow B; Ye X; Gavier-Widen D; Bhuju S; Oehlmann W; Singh M; Skold M; Ignatowicz L; Yoshimura A; Wigzell H; Rottenberg ME. 2011. Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner. J Biol Chem 286(30):26873-87. [PubMed: 21622562]  [MGI Ref ID J:175389]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598]  [MGI Ref ID J:123753]

Carrero JA; Calderon B; Unanue ER. 2004. Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection. J Exp Med 200(4):535-40. [PubMed: 15302900]  [MGI Ref ID J:93914]

Case CL; Kohler LJ; Lima JB; Strowig T; de Zoete MR; Flavell RA; Zamboni DS; Roy CR. 2013. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A 110(5):1851-6. [PubMed: 23307811]  [MGI Ref ID J:211694]

Cervantes-Barragan L; Gil-Cruz C; Pastelin-Palacios R; Lang KS; Isibasi A; Ludewig B; Lopez-Macias C. 2009. TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens. Eur J Immunol 39(1):126-35. [PubMed: 19130558]  [MGI Ref ID J:143726]

Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753]  [MGI Ref ID J:143484]

Cervantes-Barragan L; Lewis KL; Firner S; Thiel V; Hugues S; Reith W; Ludewig B; Reizis B. 2012. Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A 109(8):3012-7. [PubMed: 22315415]  [MGI Ref ID J:182008]

Cervantes-Barragan L; Zust R; Weber F; Spiegel M; Lang KS; Akira S; Thiel V; Ludewig B. 2007. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109(3):1131-7. [PubMed: 16985170]  [MGI Ref ID J:144400]

Cha HR; Ko HJ; Kim ED; Chang SY; Seo SU; Cuburu N; Ryu S; Kim S; Kweon MN. 2011. Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control. J Immunol 187(6):3044-52. [PubMed: 21832166]  [MGI Ref ID J:179255]

Chang EY; Guo B; Doyle SE; Cheng G. 2007. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol 178(11):6705-9. [PubMed: 17513714]  [MGI Ref ID J:147854]

Chen W; Han C; Xie B; Hu X; Yu Q; Shi L; Wang Q; Li D; Wang J; Zheng P; Liu Y; Cao X. 2013. Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation. Cell 152(3):467-78. [PubMed: 23374343]  [MGI Ref ID J:193456]

Chen Y; Sjolinder M; Wang X; Altenbacher G; Hagner M; Berglund P; Gao Y; Lu T; Jonsson AB; Sjolinder H. 2012. Thyroid hormone enhances nitric oxide-mediated bacterial clearance and promotes survival after meningococcal infection. PLoS One 7(7):e41445. [PubMed: 22844479]  [MGI Ref ID J:189721]

Chessler AD; Caradonna KL; Da'dara A; Burleigh BA. 2011. Type I Interferons Increase Host Susceptibility to Trypanosoma cruzi Infection. Infect Immun 79(5):2112-9. [PubMed: 21402764]  [MGI Ref ID J:171935]

Chessler AD; Unnikrishnan M; Bei AK; Daily JP; Burleigh BA. 2009. Trypanosoma cruzi triggers an early type I IFN response in vivo at the site of intradermal infection. J Immunol 182(4):2288-96. [PubMed: 19201883]  [MGI Ref ID J:144788]

Cheung DS; Ehlenbach SJ; Kitchens RT; Riley DA; Thomas LL; Holtzman MJ; Grayson MH. 2010. Cutting edge: CD49d+ neutrophils induce FcepsilonRI expression on lung dendritic cells in a mouse model of postviral asthma. J Immunol 185(9):4983-7. [PubMed: 20876348]  [MGI Ref ID J:165195]

Coers J; Vance RE; Fontana MF; Dietrich WF. 2007. Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. Cell Microbiol 9(10):2344-57. [PubMed: 17506816]  [MGI Ref ID J:148669]

Colpitts SL; Stoklasek TA; Plumlee CR; Obar JJ; Guo C; Lefrancois L. 2012. Cutting Edge: The Role of IFN-alpha Receptor and MyD88 Signaling in Induction of IL-15 Expression In Vivo. J Immunol 188(6):2483-7. [PubMed: 22327071]  [MGI Ref ID J:181848]

Conrad C; Boyman O; Tonel G; Tun-Kyi A; Laggner U; de Fougerolles A; Kotelianski V; Gardner H; Nestle FO. 2007. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13(7):836-42. [PubMed: 17603494]  [MGI Ref ID J:125083]

Conrady CD; Halford WP; Carr DJ. 2011. Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. J Virol 85(4):1625-33. [PubMed: 21147921]  [MGI Ref ID J:168790]

Conrady CD; Thapa M; Wuest T; Carr DJ. 2009. Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice. J Immunol 182(6):3678-87. [PubMed: 19265146]  [MGI Ref ID J:145922]

Coro ES; Chang WL; Baumgarth N. 2006. Type I IFN receptor signals directly stimulate local B cells early following influenza virus infection. J Immunol 176(7):4343-51. [PubMed: 16547272]  [MGI Ref ID J:129867]

Costa VM; Torres KC; Mendonca RZ; Gresser I; Gollob KJ; Abrahamsohn IA. 2006. Type I IFNs stimulate nitric oxide production and resistance to Trypanosoma cruzi infection. J Immunol 177(5):3193-200. [PubMed: 16920958]  [MGI Ref ID J:139528]

Cotter CR; Kim WK; Nguyen ML; Yount JS; Lopez CB; Blaho JA; Moran TM. 2011. The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-kappaB in dendritic cells in the absence of type I interferon signaling. J Virol 85(23):12662-72. [PubMed: 21937652]  [MGI Ref ID J:178555]

Couderc T; Chretien F; Schilte C; Disson O; Brigitte M; Guivel-Benhassine F; Touret Y; Barau G; Cayet N; Schuffenecker I; Despres P; Arenzana-Seisdedos F; Michault A; Albert ML; Lecuit M. 2008. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4(2):e29. [PubMed: 18282093]  [MGI Ref ID J:193450]

Cousens LP; Peterson R; Hsu S; Dorner A; Altman JD; Ahmed R; Biron CA. 1999. Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med 189(8):1315-28. [PubMed: 10209048]  [MGI Ref ID J:54482]

Crane MJ; Hokeness-Antonelli KL; Salazar-Mather TP. 2009. Regulation of inflammatory monocyte/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I Interferons in localized induction of CCR2 ligands. J Immunol 183(4):2810-7. [PubMed: 19620305]  [MGI Ref ID J:151550]

Creasey EA; Isberg RR. 2012. The protein SdhA maintains the integrity of the Legionella-containing vacuole. Proc Natl Acad Sci U S A 109(9):3481-6. [PubMed: 22308473]  [MGI Ref ID J:182023]

Crespo MI; Zacca ER; Nunez NG; Ranocchia RP; Maccioni M; Maletto BA; Pistoresi-Palencia MC; Moron G. 2013. TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface. J Immunol 190(3):948-60. [PubMed: 23284054]  [MGI Ref ID J:193025]

Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096]  [MGI Ref ID J:152690]

Curtsinger JM; Agarwal P; Lins DC; Mescher MF. 2012. Autocrine IFN-gamma promotes naive CD8 T cell differentiation and synergizes with IFN-alpha to stimulate strong function. J Immunol 189(2):659-68. [PubMed: 22706089]  [MGI Ref ID J:189538]

Curtsinger JM; Valenzuela JO; Agarwal P; Lins D; Mescher MF. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-9. [PubMed: 15814665]  [MGI Ref ID J:98161]

Daffis S; Suthar MS; Szretter KJ; Gale M Jr; Diamond MS. 2009. Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog 5(10):e1000607. [PubMed: 19798431]  [MGI Ref ID J:162908]

Daffis S; Szretter KJ; Schriewer J; Li J; Youn S; Errett J; Lin TY; Schneller S; Zust R; Dong H; Thiel V; Sen GC; Fensterl V; Klimstra WB; Pierson TC; Buller RM; Gale M Jr; Shi PY; Diamond MS. 2010. 2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members. Nature 468(7322):452-6. [PubMed: 21085181]  [MGI Ref ID J:187561]

Dann A; Poeck H; Croxford AL; Gaupp S; Kierdorf K; Knust M; Pfeifer D; Maihoefer C; Endres S; Kalinke U; Meuth SG; Wiendl H; Knobeloch KP; Akira S; Waisman A; Hartmann G; Prinz M. 2012. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci 15(1):98-106. [PubMed: 22138643]  [MGI Ref ID J:180319]

Day SL; Ramshaw IA; Ramsay AJ; Ranasinghe C. 2008. Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy. J Immunol 180(11):7158-66. [PubMed: 18490714]  [MGI Ref ID J:136349]

Delano MJ; Kelly-Scumpia KM; Thayer TC; Winfield RD; Scumpia PO; Cuenca AG; Harrington PB; O'Malley KA; Warner E; Gabrilovich S; Mathews CE; Laface D; Heyworth PG; Ramphal R; Strieter RM; Moldawer LL; Efron PA. 2011. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 187(2):911-8. [PubMed: 21690321]  [MGI Ref ID J:178027]

Delano MJ; Scumpia PO; Weinstein JS; Coco D; Nagaraj S; Kelly-Scumpia KM; O'Malley KA; Wynn JL; Antonenko S; Al-Quran SZ; Swan R; Chung CS; Atkinson MA; Ramphal R; Gabrilovich DI; Reeves WH; Ayala A; Phillips J; Laface D; Heyworth PG; Clare-Salzler M; Moldawer LL. 2007. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 204(6):1463-74. [PubMed: 17548519]  [MGI Ref ID J:125856]

Desvignes L; Wolf AJ; Ernst JD. 2012. Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis. J Immunol 188(12):6205-15. [PubMed: 22566567]  [MGI Ref ID J:188884]

Detje CN; Meyer T; Schmidt H; Kreuz D; Rose JK; Bechmann I; Prinz M; Kalinke U. 2009. Local type I IFN receptor signaling protects against virus spread within the central nervous system. J Immunol 182(4):2297-304. [PubMed: 19201884]  [MGI Ref ID J:144787]

Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM. 2009. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31(1):110-21. [PubMed: 19576795]  [MGI Ref ID J:151628]

Dietrich N; Lienenklaus S; Weiss S; Gekara NO. 2010. Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS One 5(4):e10250. [PubMed: 20422028]  [MGI Ref ID J:160136]

Dikopoulos N; Bertoletti A; Kroger A; Hauser H; Schirmbeck R; Reimann J. 2005. Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells. J Immunol 174(1):99-109. [PubMed: 15611232]  [MGI Ref ID J:95863]

Dillon CP; Weinlich R; Rodriguez DA; Cripps JG; Quarato G; Gurung P; Verbist KC; Brewer TL; Llambi F; Gong YN; Janke LJ; Kelliher MA; Kanneganti TD; Green DR. 2014. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell 157(5):1189-202. [PubMed: 24813850]  [MGI Ref ID J:214393]

Dogusan Z; Garcia M; Flamez D; Alexopoulou L; Goldman M; Gysemans C; Mathieu C; Libert C; Eizirik DL; Rasschaert J. 2008. Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes 57(5):1236-45. [PubMed: 18223009]  [MGI Ref ID J:135353]

Dorner M; Horwitz JA; Donovan BM; Labitt RN; Budell WC; Friling T; Vogt A; Catanese MT; Satoh T; Kawai T; Akira S; Law M; Rice CM; Ploss A. 2013. Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature 501(7466):237-41. [PubMed: 23903655]  [MGI Ref ID J:205017]

Drobits B; Holcmann M; Amberg N; Swiecki M; Grundtner R; Hammer M; Colonna M; Sibilia M. 2012. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J Clin Invest 122(2):575-85. [PubMed: 22251703]  [MGI Ref ID J:184497]

Duley AK; Ploquin MJ; Eksmond U; Ammann CG; Messer RJ; Myers L; Hasenkrug KJ; Kassiotis G. 2012. Negative impact of IFN-gamma on early host immune responses to retroviral infection. J Immunol 189(5):2521-9. [PubMed: 22821964]  [MGI Ref ID J:189729]

Dunn GP; Bruce AT; Sheehan KC; Shankaran V; Uppaluri R; Bui JD; Diamond MS; Koebel CM; Arthur C; White JM; Schreiber RD. 2005. A critical function for type I interferons in cancer immunoediting. Nat Immunol 6(7):722-9. [PubMed: 15951814]  [MGI Ref ID J:99146]

Durbin JE; Fernandez-Sesma A; Lee CK; Rao TD; Frey AB; Moran TM; Vukmanovic S; Garcia-Sastre A; Levy DE. 2000. Type I IFN modulates innate and specific antiviral immunity. J Immunol 164(8):4220-8. [PubMed: 10754318]  [MGI Ref ID J:123432]

Durbin JE; Johnson TR; Durbin RK; Mertz SE; Morotti RA; Peebles RS; Graham BS. 2002. The role of IFN in respiratory syncytial virus pathogenesis. J Immunol 168(6):2944-52. [PubMed: 11884466]  [MGI Ref ID J:126678]

Eberle ME; Dalpke AH. 2012. Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol 188(11):5644-54. [PubMed: 22547696]  [MGI Ref ID J:188728]

Ehl S; Hombach J; Aichele P; Hengartner H; Zinkernagel RM. 1997. Bystander activation of cytotoxic T cells: studies on the mechanism and evaluation of in vivo significance in a transgenic mouse model. J Exp Med 185(7):1241-51. [PubMed: 9104811]  [MGI Ref ID J:107413]

Ertelt JM; Johanns TM; Rowe JH; Way SS. 2010. Interleukin (IL)-21-independent pathogen-specific CD8+ T-cell expansion, and IL-21-dependent suppression of CD4+ T-cell IL-17 production. Immunology 131(2):183-91. [PubMed: 20465570]  [MGI Ref ID J:166404]

Fabis MJ; Scott GS; Kean RB; Koprowski H; Hooper DC. 2007. Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A 104(13):5656-61. [PubMed: 17372191]  [MGI Ref ID J:120115]

Fairhurst AM; Xie C; Fu Y; Wang A; Boudreaux C; Zhou XJ; Cibotti R; Coyle A; Connolly JE; Wakeland EK; Mohan C. 2009. Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis. J Immunol 183(10):6831-8. [PubMed: 19864599]  [MGI Ref ID J:157176]

Fallarino F; Asselin-Paturel C; Vacca C; Bianchi R; Gizzi S; Fioretti MC; Trinchieri G; Grohmann U; Puccetti P. 2004. Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement. J Immunol 173(6):3748-54. [PubMed: 15356121]  [MGI Ref ID J:92769]

Farlik M; Reutterer B; Schindler C; Greten F; Vogl C; Muller M; Decker T. 2010. Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity 33(1):25-34. [PubMed: 20637660]  [MGI Ref ID J:162548]

Faul EJ; Wanjalla CN; Suthar MS; Gale M; Wirblich C; Schnell MJ. 2010. Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling. PLoS Pathog 6(7):e1001016. [PubMed: 20661430]  [MGI Ref ID J:167937]

Feng N; Kim B; Fenaux M; Nguyen H; Vo P; Omary MB; Greenberg HB. 2008. Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol 82(15):7578-90. [PubMed: 18495762]  [MGI Ref ID J:153415]

Fensterl V; Wetzel JL; Ramachandran S; Ogino T; Stohlman SA; Bergmann CC; Diamond MS; Virgin HW; Sen GC. 2012. Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis. PLoS Pathog 8(5):e1002712. [PubMed: 22615570]  [MGI Ref ID J:195382]

Fiette L; Aubert C; Muller U; Huang S; Aguet M; Brahic M; Bureau JF. 1995. Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors. J Exp Med 181(6):2069-76. [PubMed: 7759999]  [MGI Ref ID J:25679]

Fink K; Lang KS; Manjarrez-Orduno N; Junt T; Senn BM; Holdener M; Akira S; Zinkernagel RM; Hengartner H. 2006. Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses. Eur J Immunol 36(8):2094-105. [PubMed: 16810635]  [MGI Ref ID J:115803]

Flur K; Allam R; Zecher D; Kulkarni OP; Lichtnekert J; Schwarz M; Beutler B; Vielhauer V; Anders HJ. 2009. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis. Am J Pathol 175(5):2014-22. [PubMed: 19850889]  [MGI Ref ID J:154665]

Frese M; Lee E; Larena M; Lim PS; Rao S; Matthaei KI; Khromykh A; Ramshaw I; Lobigs M. 2014. Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of Beta interferon coexpression on vaccine properties. J Virol 88(4):2056-70. [PubMed: 24307589]  [MGI Ref ID J:205265]

Fujikura D; Chiba S; Muramatsu D; Kazumata M; Nakayama Y; Kawai T; Akira S; Kida H; Miyazaki T. 2013. Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza. PLoS One 8(2):e55321. [PubMed: 23408968]  [MGI Ref ID J:197206]

Funabiki M; Kato H; Miyachi Y; Toki H; Motegi H; Inoue M; Minowa O; Yoshida A; Deguchi K; Sato H; Ito S; Shiroishi T; Takeyasu K; Noda T; Fujita T. 2014. Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 40(2):199-212. [PubMed: 24530055]  [MGI Ref ID J:209917]

Fung KY; Mangan NE; Cumming H; Horvat JC; Mayall JR; Stifter SA; De Weerd N; Roisman LC; Rossjohn J; Robertson SA; Schjenken JE; Parker B; Gargett CE; Nguyen HP; Carr DJ; Hansbro PM; Hertzog PJ. 2013. Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. Science 339(6123):1088-92. [PubMed: 23449591]  [MGI Ref ID J:197569]

Gall A; Treuting P; Elkon KB; Loo YM; Gale M Jr; Barber GN; Stetson DB. 2012. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1):120-31. [PubMed: 22284419]  [MGI Ref ID J:181257]

Garvey TL; Dyer KD; Ellis JA; Bonville CA; Foster B; Prussin C; Easton AJ; Domachowske JB; Rosenberg HF. 2005. Inflammatory responses to pneumovirus infection in IFN-alpha beta R gene-deleted mice. J Immunol 175(7):4735-44. [PubMed: 16177121]  [MGI Ref ID J:118944]

Gautier G; Humbert M; Deauvieau F; Scuiller M; Hiscott J; Bates EE; Trinchieri G; Caux C; Garrone P. 2005. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 201(9):1435-46. [PubMed: 15851485]  [MGI Ref ID J:98191]

Ge J; Gong YN; Xu Y; Shao F. 2012. Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc Natl Acad Sci U S A 109(16):6193-8. [PubMed: 22474394]  [MGI Ref ID J:183609]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

Gerlach N; Schimmer S; Weiss S; Kalinke U; Dittmer U. 2006. Effects of type I interferons on Friend retrovirus infection. J Virol 80(7):3438-44. [PubMed: 16537611]  [MGI Ref ID J:153334]

Geserick P; Kaiser F; Klemm U; Kaufmann SH; Zerrahn J. 2004. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol 16(10):1535-48. [PubMed: 15351786]  [MGI Ref ID J:93660]

Giannakopoulos NV; Luo JK; Papov V; Zou W; Lenschow DJ; Jacobs BS; Borden EC; Li J; Virgin HW; Zhang DE. 2005. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem Biophys Res Commun 336(2):496-506. [PubMed: 16139798]  [MGI Ref ID J:100999]

Gibbert K; Dietze KK; Zelinskyy G; Lang KS; Barchet W; Kirschning CJ; Dittmer U. 2010. Polyinosinic-polycytidylic Acid treatment of friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease. J Immunol 185(10):6179-89. [PubMed: 20943997]  [MGI Ref ID J:165633]

Gil MP; Bohn E; O'Guin AK; Ramana CV; Levine B; Stark GR; Virgin HW; Schreiber RD. 2001. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 98(12):6680-5. [PubMed: 11390995]  [MGI Ref ID J:81243]

Gill N; Chenoweth MJ; Verdu EF; Ashkar AA. 2011. NK cells require type I IFN receptor for antiviral responses during genital HSV-2 infection. Cell Immunol 269(1):29-37. [PubMed: 21477795]  [MGI Ref ID J:172288]

Giltiay NV; Chappell CP; Sun X; Kolhatkar N; Teal TH; Wiedeman AE; Kim J; Tanaka L; Buechler MB; Hamerman JA; Imanishi-Kari T; Clark EA; Elkon KB. 2013. Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells. J Exp Med 210(12):2773-89. [PubMed: 24145511]  [MGI Ref ID J:207730]

Gimeno R; Lee CK; Schindler C; Levy DE. 2005. Stat1 and stat2 but not stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes. Mol Cell Biol 25(13):5456-65. [PubMed: 15964802]  [MGI Ref ID J:99124]

Giordano G; van den Brule S; Lo Re S; Triqueneaux P; Uwambayinema F; Yakoub Y; Couillin I; Ryffel B; Michiels T; Renauld JC; Lison D; Huaux F. 2010. Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis. Toxicol Sci 116(2):682-92. [PubMed: 20513754]  [MGI Ref ID J:162924]

Globisch T; Steiner N; Fulle L; Lukacs-Kornek V; Degrandi D; Dresing P; Alferink J; Lang R; Pfeffer K; Beyer M; Weighardt H; Kurts C; Ulas T; Schultze JL; Forster I. 2014. Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur J Immunol 44(2):500-10. [PubMed: 24136200]  [MGI Ref ID J:208732]

Goto Y; Ogawa K; Nakamura TJ; Hattori A; Tsujimoto M. 2014. TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. J Immunol 192(9):4443-52. [PubMed: 24688025]  [MGI Ref ID J:209965]

Gourzi P; Leonova T; Papavasiliou FN. 2007. Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB. J Exp Med 204(2):259-65. [PubMed: 17242162]  [MGI Ref ID J:125375]

Gray RC; Kuchtey J; Harding CV. 2007. CpG-B ODNs potently induce low levels of IFN-alphabeta and induce IFN-alphabeta-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs. J Leukoc Biol 81(4):1075-85. [PubMed: 17227820]  [MGI Ref ID J:121447]

Grayson MH; Cheung D; Rohlfing MM; Kitchens R; Spiegel DE; Tucker J; Battaile JT; Alevy Y; Yan L; Agapov E; Kim EY; Holtzman MJ. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204(11):2759-69. [PubMed: 17954569]  [MGI Ref ID J:126124]

Green NM; Laws A; Kiefer K; Busconi L; Kim YM; Brinkmann MM; Trail EH; Yasuda K; Christensen SR; Shlomchik MJ; Vogel S; Connor JH; Ploegh H; Eilat D; Rifkin IR; van Seventer JM; Marshak-Rothstein A. 2009. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol 183(3):1569-76. [PubMed: 19587008]  [MGI Ref ID J:151708]

Gregorio J; Meller S; Conrad C; Di Nardo A; Homey B; Lauerma A; Arai N; Gallo RL; Digiovanni J; Gilliet M. 2010. Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons. J Exp Med 207(13):2921-30. [PubMed: 21115688]  [MGI Ref ID J:176867]

Grimm D; Staeheli P; Hufbauer M; Koerner I; Martinez-Sobrido L; Solorzano A; Garcia-Sastre A; Haller O; Kochs G. 2007. Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci U S A 104(16):6806-11. [PubMed: 17426143]  [MGI Ref ID J:120938]

Grob P; Schijns VE; van den Broek MF; Cox SP; Ackermann M; Suter M. 1999. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol 73(6):4748-54. [PubMed: 10233935]  [MGI Ref ID J:110066]

Guarda G; Braun M; Staehli F; Tardivel A; Mattmann C; Forster I; Farlik M; Decker T; Du Pasquier RA; Romero P; Tschopp J. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2):213-23. [PubMed: 21349431]  [MGI Ref ID J:168972]

Guo B; Chang EY; Cheng G. 2008. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 118(5):1680-90. [PubMed: 18382764]  [MGI Ref ID J:136169]

Han JH; Umiker BR; Kazimirova AA; Fray M; Korgaonkar P; Selsing E; Imanishi-Kari T. 2014. Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression. Eur J Immunol 44(1):215-26. [PubMed: 24105635]  [MGI Ref ID J:208660]

Havenar-Daughton C; Kolumam GA; Murali-Krishna K. 2006. Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection. J Immunol 176(6):3315-9. [PubMed: 16517698]  [MGI Ref ID J:129538]

Hayashi T; Cottam HB; Chan M; Jin G; Tawatao RI; Crain B; Ronacher L; Messer K; Carson DA; Corr M. 2008. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295(1):R123-32. [PubMed: 18480244]  [MGI Ref ID J:148644]

Heer AK; Shamshiev A; Donda A; Uematsu S; Akira S; Kopf M; Marsland BJ. 2007. TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J Immunol 178(4):2182-91. [PubMed: 17277123]  [MGI Ref ID J:143991]

Hefti HP; Frese M; Landis H; Di Paolo C; Aguzzi A; Haller O; Pavlovic J. 1999. Human MxA protein protects mice lacking a functional alpha/beta interferon system against La crosse virus and other lethal viral infections. J Virol 73(8):6984-91. [PubMed: 10400797]  [MGI Ref ID J:119783]

Hegazy AN; Peine M; Helmstetter C; Panse I; Frohlich A; Bergthaler A; Flatz L; Pinschewer DD; Radbruch A; Lohning M. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32(1):116-28. [PubMed: 20079668]  [MGI Ref ID J:157702]

Heidegger S; Anz D; Stephan N; Bohn B; Herbst T; Fendler WP; Suhartha N; Sandholzer N; Kobold S; Hotz C; Eisenacher K; Radtke-Schuller S; Endres S; Bourquin C. 2013. Virus-associated activation of innate immunity induces rapid disruption of Peyer's patches in mice. Blood 122(15):2591-9. [PubMed: 23823318]  [MGI Ref ID J:203305]

Hemmi H; Kaisho T; Takeda K; Akira S. 2003. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol 170(6):3059-64. [PubMed: 12626561]  [MGI Ref ID J:126236]

Henry T; Brotcke A; Weiss DS; Thompson LJ; Monack DM. 2007. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J Exp Med 204(5):987-94. [PubMed: 17452523]  [MGI Ref ID J:125737]

Henry T; Kirimanjeswara GS; Ruby T; Jones JW; Peng K; Perret M; Ho L; Sauer JD; Iwakura Y; Metzger DW; Monack DM. 2010. Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections. J Immunol 184(7):3755-67. [PubMed: 20176744]  [MGI Ref ID J:160099]

Hensley SE; Giles-Davis W; McCoy KC; Weninger W; Ertl HC. 2005. Dendritic cell maturation, but not CD8+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors. J Immunol 175(9):6032-41. [PubMed: 16237098]  [MGI Ref ID J:119386]

Hermant P; Demarez C; Mahlakoiv T; Staeheli P; Meuleman P; Michiels T. 2014. Human but not mouse hepatocytes respond to interferon-lambda in vivo. PLoS One 9(1):e87906. [PubMed: 24498220]  [MGI Ref ID J:212777]

Hernandez-Cuellar E; Tsuchiya K; Hara H; Fang R; Sakai S; Kawamura I; Akira S; Mitsuyama M. 2012. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 189(11):5113-7. [PubMed: 23100513]  [MGI Ref ID J:190677]

Hervas-Stubbs S; Olivier A; Boisgerault F; Thieblemont N; Leclerc C. 2007. TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help. Blood 109(12):5318-26. [PubMed: 17339421]  [MGI Ref ID J:145420]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hida S; Tadachi M; Saito T; Taki S. 2005. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106(6):2011-7. [PubMed: 15914553]  [MGI Ref ID J:118863]

Hokeness KL; Kuziel WA; Biron CA; Salazar-Mather TP. 2005. Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liver. J Immunol 174(3):1549-56. [PubMed: 15661915]  [MGI Ref ID J:96407]

Honda K; Sakaguchi S; Nakajima C; Watanabe A; Yanai H; Matsumoto M; Ohteki T; Kaisho T; Takaoka A; Akira S; Seya T; Taniguchi T. 2003. Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A 100(19):10872-7. [PubMed: 12960379]  [MGI Ref ID J:114555]

Hoshino K; Sasaki I; Sugiyama T; Yano T; Yamazaki C; Yasui T; Kikutani H; Kaisho T. 2010. Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells. J Immunol 184(7):3341-5. [PubMed: 20200270]  [MGI Ref ID J:160080]

Hou B; Reizis B; Defranco AL. 2008. Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms. Immunity 29(2):272-82. [PubMed: 18656388]  [MGI Ref ID J:139001]

Hron JD; Peng SL. 2004. Type I IFN protects against murine lupus. J Immunol 173(3):2134-42. [PubMed: 15265950]  [MGI Ref ID J:92084]

Huang L; Li L; Klonowski KD; Tompkins SM; Tripp RA; Mellor AL. 2013. Induction and role of indoleamine 2,3 dioxygenase in mouse models of influenza a virus infection. PLoS One 8(6):e66546. [PubMed: 23785507]  [MGI Ref ID J:203475]

Huangfu WC; Liu J; Harty RN; Fuchs SY. 2008. Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor. FEBS Lett 582(21-22):3206-3210. [PubMed: 18722370]  [MGI Ref ID J:139676]

Humann J; Bjordahl R; Andreasen K; Lenz LL. 2007. Expression of the p60 autolysin enhances NK cell activation and is required for listeria monocytogenes expansion in IFN-gamma-responsive mice. J Immunol 178(4):2407-14. [PubMed: 17277147]  [MGI Ref ID J:143979]

Iannacone M; Sitia G; Isogawa M; Whitmire JK; Marchese P; Chisari FV; Ruggeri ZM; Guidotti LG. 2008. Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A 105(2):629-34. [PubMed: 18184798]  [MGI Ref ID J:131089]

Ichikawa E; Hida S; Omatsu Y; Shimoyama S; Takahara K; Miyagawa S; Inaba K; Taki S. 2004. Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2. Proc Natl Acad Sci U S A 101(11):3909-14. [PubMed: 15004277]  [MGI Ref ID J:88889]

Ida-Hosonuma M; Iwasaki T; Yoshikawa T; Nagata N; Sato Y; Sata T; Yoneyama M; Fujita T; Taya C; Yonekawa H; Koike S. 2005. The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol 79(7):4460-9. [PubMed: 15767446]  [MGI Ref ID J:97037]

Iliopoulos D; Kavousanaki M; Ioannou M; Boumpas D; Verginis P. 2011. The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21. Eur J Immunol 41(6):1754-63. [PubMed: 21469086]  [MGI Ref ID J:176637]

Ireland DD; Stohlman SA; Hinton DR; Atkinson R; Bergmann CC. 2008. Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol 82(1):300-10. [PubMed: 17928334]  [MGI Ref ID J:145215]

Iyer SS; Ghaffari AA; Cheng G. 2010. Lipopolysaccharide-Mediated IL-10 Transcriptional Regulation Requires Sequential Induction of Type I IFNs and IL-27 in Macrophages. J Immunol 185(11):6599-607. [PubMed: 21041726]  [MGI Ref ID J:166135]

Jacob N; Guo S; Mathian A; Koss MN; Gindea S; Putterman C; Jacob CO; Stohl W. 2011. B Cell and BAFF dependence of IFN-alpha-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice. J Immunol 186(8):4984-93. [PubMed: 21383240]  [MGI Ref ID J:172469]

Jarousse N; Trujillo DL; Wilcox-Adelman S; Coscoy L. 2011. Virally-induced upregulation of heparan sulfate on B cells via the action of type I IFN. J Immunol 187(11):5540-7. [PubMed: 22048770]  [MGI Ref ID J:179698]

Jia T; Leiner I; Dorothee G; Brandl K; Pamer EG. 2009. MyD88 and Type I interferon receptor-mediated chemokine induction and monocyte recruitment during Listeria monocytogenes infection. J Immunol 183(2):1271-8. [PubMed: 19553532]  [MGI Ref ID J:151402]

Johansson C; Wetzel JD; He J; Mikacenic C; Dermody TS; Kelsall BL. 2007. Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. J Exp Med 204(6):1349-58. [PubMed: 17502662]  [MGI Ref ID J:125865]

Johnson TR; Mertz SE; Gitiban N; Hammond S; Legallo R; Durbin RK; Durbin JE. 2005. Role for innate IFNs in determining respiratory syncytial virus immunopathology. J Immunol 174(11):7234-41. [PubMed: 15905569]  [MGI Ref ID J:99027]

Jones JW; Kayagaki N; Broz P; Henry T; Newton K; O'Rourke K; Chan S; Dong J; Qu Y; Roose-Girma M; Dixit VM; Monack DM. 2010. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc Natl Acad Sci U S A 107(21):9771-6. [PubMed: 20457908]  [MGI Ref ID J:160545]

Jung A; Kato H; Kumagai Y; Kumar H; Kawai T; Takeuchi O; Akira S. 2008. Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88. J Virol 82(1):196-206. [PubMed: 17942529]  [MGI Ref ID J:153312]

Kamphuis E; Junt T; Waibler Z; Forster R; Kalinke U. 2006. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10):3253-61. [PubMed: 16868248]  [MGI Ref ID J:140450]

Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. [PubMed: 19006696]  [MGI Ref ID J:142395]

Kang TH; Mao CP; Lee SY; Chen A; Lee JH; Kim TW; Alvarez RD; Roden RB; Pardoll D; Hung CF; Wu TC. 2013. Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity. Cancer Res 73(8):2493-504. [PubMed: 23418322]  [MGI Ref ID J:196970]

Kanistanon D; Powell DA; Hajjar AM; Pelletier MR; Cohen IE; Way SS; Skerrett SJ; Wang X; Raetz CR; Ernst RK. 2012. Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses. Infect Immun 80(3):943-51. [PubMed: 22215738]  [MGI Ref ID J:182434]

Karges W; Rajasalu T; Spyrantis A; Wieland A; Boehm B; Schirmbeck R. 2007. The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice. Eur J Immunol 37(8):2097-103. [PubMed: 17615584]  [MGI Ref ID J:123542]

Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. [PubMed: 23352234]  [MGI Ref ID J:194479]

Kastenmuller W; Torabi-Parizi P; Subramanian N; Lammermann T; Germain RN. 2012. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 150(6):1235-48. [PubMed: 22980983]  [MGI Ref ID J:187962]

Katakura K; Lee J; Rachmilewitz D; Li G; Eckmann L; Raz E. 2005. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115(3):695-702. [PubMed: 15765149]  [MGI Ref ID J:110027]

Kato H; Takeuchi O; Sato S; Yoneyama M; Yamamoto M; Matsui K; Uematsu S; Jung A; Kawai T; Ishii KJ; Yamaguchi O; Otsu K; Tsujimura T; Koh CS; Reis e Sousa C; Matsuura Y; Fujita T; Akira S. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441(7089):101-5. [PubMed: 16625202]  [MGI Ref ID J:137522]

Kawane K; Ohtani M; Miwa K; Kizawa T; Kanbara Y; Yoshioka Y; Yoshikawa H; Nagata S. 2006. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443(7114):998-1002. [PubMed: 17066036]  [MGI Ref ID J:114982]

Kawane K; Tanaka H; Kitahara Y; Shimaoka S; Nagata S. 2010. Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation. Proc Natl Acad Sci U S A 107(45):19432-7. [PubMed: 20974942]  [MGI Ref ID J:167378]

Kearney SJ; Delgado C; Eshleman EM; Hill KK; O'Connor BP; Lenz LL. 2013. Type I IFNs downregulate myeloid cell IFN-gamma receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol 191(6):3384-92. [PubMed: 23935197]  [MGI Ref ID J:205781]

Kelly-Scumpia KM; Scumpia PO; Weinstein JS; Delano MJ; Cuenca AG; Nacionales DC; Wynn JL; Lee PY; Kumagai Y; Efron PA; Akira S; Wasserfall C; Atkinson MA; Moldawer LL. 2011. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med 208(8):1673-82. [PubMed: 21746813]  [MGI Ref ID J:177607]

Keppler SJ; Aichele P. 2011. Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen. Eur J Immunol 41(11):3176-86. [PubMed: 21830209]  [MGI Ref ID J:179523]

Kernbauer E; Maier V; Rauch I; Muller M; Decker T. 2013. Route of Infection Determines the Impact of Type I Interferons on Innate Immunity to PLoS One 8(6):e65007. [PubMed: 23840314]  [MGI Ref ID J:203726]

Kernbauer E; Maier V; Stoiber D; Strobl B; Schneckenleithner C; Sexl V; Reichart U; Reizis B; Kalinke U; Jamieson A; Muller M; Decker T. 2012. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 8(6):e1002763. [PubMed: 22719255]  [MGI Ref ID J:195380]

Khan S; van den Broek M; Schwarz K; de Giuli R; Diener PA; Groettrup M. 2001. Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver. J Immunol 167(12):6859-68. [PubMed: 11739503]  [MGI Ref ID J:73089]

Khong WX; Yan B; Yeo H; Tan EL; Lee JJ; Ng JK; Chow VT; Alonso S. 2012. A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection. J Virol 86(4):2121-31. [PubMed: 22130542]  [MGI Ref ID J:181145]

Khorooshi R; Owens T. 2010. Injury-induced type I IFN signaling regulates inflammatory responses in the central nervous system. J Immunol 185(2):1258-64. [PubMed: 20562259]  [MGI Ref ID J:161928]

Kim JH; Kim K; Jin HM; Song I; Youn BU; Lee SH; Choi Y; Kim N. 2010. Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1. J Biol Chem 285(8):5224-31. [PubMed: 20037154]  [MGI Ref ID J:159891]

Kim JH; Kim SJ; Lee IS; Lee MS; Uematsu S; Akira S; Oh KI. 2009. Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway. J Immunol 182(4):2458-66. [PubMed: 19201901]  [MGI Ref ID J:144779]

Kim KI; Malakhova OA; Hoebe K; Yan M; Beutler B; Zhang DE. 2005. Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. J Immunol 175(2):847-54. [PubMed: 16002682]  [MGI Ref ID J:100695]

Kimura K; Kakimi K; Wieland S; Guidotti LG; Chisari FV. 2002. Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J Immunol 169(9):5188-95. [PubMed: 12391236]  [MGI Ref ID J:79786]

Kitahara Y; Kawane K; Nagata S. 2010. Interferon-induced TRAIL-independent cell death in DNase II-/- embryos. Eur J Immunol 40(9):2590-8. [PubMed: 20706988]  [MGI Ref ID J:165737]

Klein MA; Frigg R; Flechsig E; Raeber AJ; Kalinke U; Bluethmann H; Bootz F; Suter M; Zinkernagel RM; Aguzzi A. 1997. A crucial role for B cells in neuroinvasive scrapie [see comments] Nature 390(6661):687-90. [PubMed: 9414161]  [MGI Ref ID J:44933]

Kleinman ME; Yamada K; Takeda A; Chandrasekaran V; Nozaki M; Baffi JZ; Albuquerque RJ; Yamasaki S; Itaya M; Pan Y; Appukuttan B; Gibbs D; Yang Z; Kariko K; Ambati BK; Wilgus TA; DiPietro LA; Sakurai E; Zhang K; Smith JR; Taylor EW; Ambati J. 2008. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452(7187):591-7. [PubMed: 18368052]  [MGI Ref ID J:133772]

Knudsen ML; Ljungberg K; Kakoulidou M; Kostic L; Hallengard D; Garcia-Arriaza J; Merits A; Esteban M; Liljestrom P. 2014. Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations. J Virol 88(21):12438-51. [PubMed: 25122792]  [MGI Ref ID J:217075]

Kochs G; Bauer S; Vogt C; Frenz T; Tschopp J; Kalinke U; Waibler Z. 2010. Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. J Virol 84(23):12344-50. [PubMed: 20861272]  [MGI Ref ID J:165800]

Koerner I; Kochs G; Kalinke U; Weiss S; Staeheli P. 2007. Protective role of beta interferon in host defense against influenza A virus. J Virol 81(4):2025-30. [PubMed: 17151098]  [MGI Ref ID J:123849]

Koga R; Hamano S; Kuwata H; Atarashi K; Ogawa M; Hisaeda H; Yamamoto M; Akira S; Himeno K; Matsumoto M; Takeda K. 2006. TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi. J Immunol 177(10):7059-66. [PubMed: 17082622]  [MGI Ref ID J:140485]

Koga R; Ohno S; Ikegame S; Yanagi Y. 2010. Measles virus-induced immunosuppression in SLAM knock-in mice. J Virol 84(10):5360-7. [PubMed: 20200244]  [MGI Ref ID J:160780]

Kole A; He J; Rivollier A; Silveira DD; Kitamura K; Maloy KJ; Kelsall BL. 2013. Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis. J Immunol 191(5):2771-9. [PubMed: 23913971]  [MGI Ref ID J:205804]

Kolokoltsova OA; Yun NE; Poussard AL; Smith JK; Smith JN; Salazar M; Walker A; Tseng CT; Aronson JF; Paessler S. 2010. Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection. J Virol 84(24):13063-7. [PubMed: 20926559]  [MGI Ref ID J:166539]

Kolumam GA; Thomas S; Thompson LJ; Sprent J; Murali-Krishna K. 2005. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 202(5):637-50. [PubMed: 16129706]  [MGI Ref ID J:100725]

Koppe U; Hogner K; Doehn JM; Muller HC; Witzenrath M; Gutbier B; Bauer S; Pribyl T; Hammerschmidt S; Lohmeyer J; Suttorp N; Herold S; Opitz B. 2012. Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs. J Immunol 188(2):811-7. [PubMed: 22156592]  [MGI Ref ID J:180799]

Koschella M; Voehringer D; Pircher H. 2004. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol 172(8):4804-11. [PubMed: 15067057]  [MGI Ref ID J:89113]

Ksienzyk A; Neumann B; Nandakumar R; Finsterbusch K; Grashoff M; Zawatzky R; Bernhardt G; Hauser H; Kroger A. 2011. IRF-1 Expression Is Essential for Natural Killer Cells to Suppress Metastasis. Cancer Res 71(20):6410-8. [PubMed: 21900395]  [MGI Ref ID J:177045]

Kuchtey J; Chefalo PJ; Gray RC; Ramachandra L; Harding CV. 2005. Enhancement of dendritic cell antigen cross-presentation by CpG DNA involves type I IFN and stabilization of class I MHC mRNA. J Immunol 175(4):2244-51. [PubMed: 16081792]  [MGI Ref ID J:107511]

Kuchtey J; Fulton SA; Reba SM; Harding CV; Boom WH. 2006. Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guerin infection. Immunology 118(1):39-49. [PubMed: 16630021]  [MGI Ref ID J:109682]

Kulkarni RR; Rasheed MA; Bhaumik SK; Ranjan P; Cao W; Davis C; Marisetti K; Thomas S; Gangappa S; Sambhara S; Murali-Krishna K. 2014. Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. J Virol 88(24):13990-4001. [PubMed: 25253340]  [MGI Ref ID J:217552]

Kurche JS; Haluszczak C; McWilliams JA; Sanchez PJ; Kedl RM. 2012. Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol 188(2):585-93. [PubMed: 22156349]  [MGI Ref ID J:180881]

Kurnellas MP; Schartner JM; Fathman CG; Jagger A; Steinman L; Rothbard JB. 2014. Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease. J Exp Med 211(9):1847-56. [PubMed: 25073790]  [MGI Ref ID J:218116]

Kuss SK; Etheredge CA; Pfeiffer JK. 2008. Multiple host barriers restrict poliovirus trafficking in mice. PLoS Pathog 4(6):e1000082. [PubMed: 18535656]  [MGI Ref ID J:162722]

Kuwajima S; Sato T; Ishida K; Tada H; Tezuka H; Ohteki T. 2006. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7(7):740-6. [PubMed: 16715101]  [MGI Ref ID J:112665]

Lalanne AI; Moraga I; Hao Y; Pereira JP; Alves NL; Huntington ND; Freitas AA; Cumano A; Vieira P. 2010. CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol 184(10):5678-85. [PubMed: 20400700]  [MGI Ref ID J:160995]

Lancaster KZ; Pfeiffer JK. 2010. Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response. PLoS Pathog 6(3):e1000791. [PubMed: 20221252]  [MGI Ref ID J:162880]

Lang KS; Recher M; Junt T; Navarini AA; Harris NL; Freigang S; Odermatt B; Conrad C; Ittner LM; Bauer S; Luther SA; Uematsu S; Akira S; Hengartner H; Zinkernagel RM. 2005. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med 11(2):138-45. [PubMed: 15654326]  [MGI Ref ID J:96036]

Lazear HM; Lancaster A; Wilkins C; Suthar MS; Huang A; Vick SC; Clepper L; Thackray L; Brassil MM; Virgin HW; Nikolich-Zugich J; Moses AV; Gale M Jr; Fruh K; Diamond MS. 2013. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog 9(1):e1003118. [PubMed: 23300459]  [MGI Ref ID J:195894]

Le Bon A; Etchart N; Rossmann C; Ashton M; Hou S; Gewert D; Borrow P; Tough DF. 2003. Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat Immunol 4(10):1009-15. [PubMed: 14502286]  [MGI Ref ID J:125600]

Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962]  [MGI Ref ID J:129128]

Lebel ME; Daudelin JF; Chartrand K; Tarrab E; Kalinke U; Savard P; Labrecque N; Leclerc D; Lamarre A. 2014. Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection. J Immunol 192(3):1071-8. [PubMed: 24376264]  [MGI Ref ID J:207307]

Lee CC; Kung JT. 2012. Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J Immunol 189(7):3319-27. [PubMed: 22933629]  [MGI Ref ID J:190348]

Lee CK; Gimeno R; Levy DE. 1999. Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes. J Exp Med 190(10):1451-64. [PubMed: 10562320]  [MGI Ref ID J:58494]

Lee CK; Smith E; Gimeno R; Gertner R; Levy DE. 2000. STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-gamma J Immunol 164(3):1286-92. [PubMed: 10640742]  [MGI Ref ID J:59955]

Lee PY; Li Y; Kumagai Y; Xu Y; Weinstein JS; Kellner ES; Nacionales DC; Butfiloski EJ; van Rooijen N; Akira S; Sobel ES; Satoh M; Reeves WH. 2009. Type I interferon modulates monocyte recruitment and maturation in chronic inflammation. Am J Pathol 175(5):2023-33. [PubMed: 19808647]  [MGI Ref ID J:154704]

Lee PY; Weinstein JS; Nacionales DC; Scumpia PO; Li Y; Butfiloski E; van Rooijen N; Moldawer L; Satoh M; Reeves WH. 2008. A Novel Type I IFN-Producing Cell Subset in Murine Lupus. J Immunol 180(7):5101-8. [PubMed: 18354236]  [MGI Ref ID J:133377]

Leib DA; Machalek MA; Williams BR; Silverman RH; Virgin HW. 2000. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene [see comments] Proc Natl Acad Sci U S A 97(11):6097-101. [PubMed: 10801979]  [MGI Ref ID J:62296]

Lenschow DJ; Lai C; Frias-Staheli N; Giannakopoulos NV; Lutz A; Wolff T; Osiak A; Levine B; Schmidt RE; Garcia-Sastre A; Leib DA; Pekosz A; Knobeloch KP; Horak I; Virgin HW 4th. 2007. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A 104(4):1371-6. [PubMed: 17227866]  [MGI Ref ID J:119518]

Leonova KI; Brodsky L; Lipchick B; Pal M; Novototskaya L; Chenchik AA; Sen GC; Komarova EA; Gudkov AV. 2013. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proc Natl Acad Sci U S A 110(1):E89-98. [PubMed: 23236145]  [MGI Ref ID J:192543]

Li H; Matte-Martone C; Tan HS; Venkatesan S; McNiff J; Demetris AJ; Jain D; Lakkis F; Rothstein D; Shlomchik WD. 2011. Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells. J Immunol 186(1):230-41. [PubMed: 21098219]  [MGI Ref ID J:168013]

Li W; Hofer MJ; Jung SR; Lim SL; Campbell IL. 2014. IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. J Virol 88(13):7578-88. [PubMed: 24760883]  [MGI Ref ID J:214415]

Lieke T; Steeg C; Graefe SE; Fleischer B; Jacobs T. 2006. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. Clin Exp Immunol 145(2):357-64. [PubMed: 16879257]  [MGI Ref ID J:112856]

Lin AC; Dissanayake D; Dhanji S; Elford AR; Ohashi PS. 2011. Different toll-like receptor stimuli have a profound impact on cytokines required to break tolerance and induce autoimmunity. PLoS One 6(9):e23940. [PubMed: 21931625]  [MGI Ref ID J:177886]

Lin L; Hou J; Ma F; Wang P; Liu X; Li N; Wang J; Wang Q; Cao X. 2013. Type I IFN inhibits innate IL-10 production in macrophages through histone deacetylase 11 by downregulating microRNA-145. J Immunol 191(7):3896-904. [PubMed: 23980205]  [MGI Ref ID J:205964]

Lin Q; Dong C; Cooper MD. 1998. Impairment of T and B cell development by treatment with a type I interferon. J Exp Med 187(1):79-87. [PubMed: 9419213]  [MGI Ref ID J:118764]

Liou LY; Blasius AL; Welch MJ; Colonna M; Oldstone MB; Zuniga EI. 2008. In vivo conversion of BM plasmacytoid DC into CD11b(+) conventional DC during virus infection. Eur J Immunol 38(12):3388-94. [PubMed: 18979509]  [MGI Ref ID J:143223]

Litvak V; Ratushny AV; Lampano AE; Schmitz F; Huang AC; Raman A; Rust AG; Bergthaler A; Aitchison JD; Aderem A. 2012. A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature 490(7420):421-5. [PubMed: 22982991]  [MGI Ref ID J:189233]

Liu Y; Carlsson R; Comabella M; Wang J; Kosicki M; Carrion B; Hasan M; Wu X; Montalban X; Dziegiel MH; Sellebjerg F; Sorensen PS; Helin K; Issazadeh-Navikas S. 2014. FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS. Nat Med 20(3):272-82. [PubMed: 24531377]  [MGI Ref ID J:208760]

Liu Y; Wu B; Paessler S; Walker DH; Tesh RB; Yu XJ. 2014. The pathogenesis of severe Fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: insights into the pathologic mechanisms of a new viral hemorrhagic Fever. J Virol 88(3):1781-6. [PubMed: 24257618]  [MGI Ref ID J:205279]

Liu YC; Gray RC; Hardy GA; Kuchtey J; Abbott DW; Emancipator SN; Harding CV. 2010. CpG-B oligodeoxynucleotides inhibit TLR-dependent and -independent induction of type I IFN in dendritic cells. J Immunol 184(7):3367-76. [PubMed: 20181884]  [MGI Ref ID J:160096]

Liu YC; Simmons DP; Li X; Abbott DW; Boom WH; Harding CV. 2012. TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9. J Immunol 188(3):1019-26. [PubMed: 22227568]  [MGI Ref ID J:181218]

Lochhead RB; Sonderegger FL; Ma Y; Brewster JE; Cornwall D; Maylor-Hagen H; Miller JC; Zachary JF; Weis JH; Weis JJ. 2012. Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol 189(5):2488-501. [PubMed: 22851707]  [MGI Ref ID J:189857]

Longman RS; Braun D; Pellegrini S; Rice CM; Darnell RB; Albert ML. 2007. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood 109(3):1113-22. [PubMed: 17018853]  [MGI Ref ID J:144394]

Lopez R; Demick KP; Mansfield JM; Paulnock DM. 2008. Type I IFNs play a role in early resistance, but subsequent susceptibility, to the African trypanosomes. J Immunol 181(7):4908-17. [PubMed: 18802094]  [MGI Ref ID J:142740]

Lucas M; Schachterle W; Oberle K; Aichele P; Diefenbach A. 2007. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26(4):503-17. [PubMed: 17398124]  [MGI Ref ID J:123584]

Madera RF; Wang JP; Libraty DH. 2011. The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses. PLoS One 6(12):e29412. [PubMed: 22206014]  [MGI Ref ID J:182342]

Mahieu T; Park JM; Revets H; Pasche B; Lengeling A; Staelens J; Wullaert A; Vanlaere I; Hochepied T; van Roy F; Karin M; Libert C. 2006. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A 103(7):2292-7. [PubMed: 16455798]  [MGI Ref ID J:106066]

Majer O; Bourgeois C; Zwolanek F; Lassnig C; Kerjaschki D; Mack M; Muller M; Kuchler K. 2012. Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections. PLoS Pathog 8(7):e1002811. [PubMed: 22911155]  [MGI Ref ID J:195371]

Majewska-Szczepanik M; Paust S; von Andrian UH; Askenase PW; Szczepanik M. 2013. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-alpha, interferon-gamma and interleukin-12. Immunology 140(1):98-110. [PubMed: 23659714]  [MGI Ref ID J:202643]

Mancuso G; Midiri A; Biondo C; Beninati C; Zummo S; Galbo R; Tomasello F; Gambuzza M; Macri G; Ruggeri A; Leanderson T; Teti G. 2007. Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria. J Immunol 178(5):3126-33. [PubMed: 17312160]  [MGI Ref ID J:144305]

Maragno AL; Pironin M; Alcalde H; Cong X; Knobeloch KP; Tangy F; Zhang DE; Ghysdael J; Quang CT. 2011. ISG15 modulates development of the erythroid lineage. PLoS One 6(10):e26068. [PubMed: 22022510]  [MGI Ref ID J:178099]

Maroun LE; Heffernan TN; Hallam DM. 2000. Partial IFN-alpha/beta and IFN-gamma receptor knockout trisomy 16 mouse fetuses show improved growth and cultured neuron viability J Interferon Cytokine Res 20(2):197-203. [PubMed: 10714556]  [MGI Ref ID J:61279]

Marshall HD; Prince AL; Berg LJ; Welsh RM. 2010. IFN-alphabeta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions. J Immunol 185(3):1419-28. [PubMed: 20592282]  [MGI Ref ID J:162457]

Marshall-Clarke S; Tasker L; Buchatska O; Downes J; Pennock J; Wharton S; Borrow P; Wiseman DZ. 2006. Influenza H2 haemagglutinin activates B cells via a MyD88-dependent pathway. Eur J Immunol 36(1):95-106. [PubMed: 16323245]  [MGI Ref ID J:113854]

Matsuda M; Nakamoto Y; Suzuki S; Kurata T; Kaneko S. 2005. Interferon-gamma-mediated hepatocarcinogenesis in mice treated with diethylnitrosamine. Lab Invest 85(5):655-63. [PubMed: 15765122]  [MGI Ref ID J:98206]

Matsui H; Tomizawa H; Eiho K; Kashiwazaki Y; Edwards S; Biffen M; Bell JP; Bahl A; Leishman AJ; Murray CM; Takaku H; Ueda Y. 2012. Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist. J Immunol 189(11):5194-205. [PubMed: 23125414]  [MGI Ref ID J:190975]

Mattei F; Bracci L; Tough DF; Belardelli F; Schiavoni G. 2009. Type I IFN regulate DC turnover in vivo. Eur J Immunol 39(7):1807-1818. [PubMed: 19544312]  [MGI Ref ID J:150275]

McClary H; Koch R; Chisari FV; Guidotti LG. 2000. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J Virol 74(5):2255-64. [PubMed: 10666256]  [MGI Ref ID J:126989]

Meissner N; Rutkowski M; Harmsen AL; Han S; Harmsen AG. 2007. Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung. J Immunol 178(10):6604-15. [PubMed: 17475892]  [MGI Ref ID J:146103]

Meissner N; Swain S; McInnerney K; Han S; Harmsen AG. 2010. Type-I IFN signaling suppresses an excessive IFN-gamma response and thus prevents lung damage and chronic inflammation during pneumocystis (PC) clearance in CD4 T cell-competent mice. Am J Pathol 176(6):2806-18. [PubMed: 20395428]  [MGI Ref ID J:161163]

Meissner NN; Swain S; Tighe M; Harmsen A; Harmsen A. 2005. Role of type I IFNs in pulmonary complications of Pneumocystis murina infection. J Immunol 174(9):5462-71. [PubMed: 15843544]  [MGI Ref ID J:98407]

Mellor AL; Baban B; Chandler PR; Manlapat A; Kahler DJ; Munn DH. 2005. Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling. J Immunol 175(9):5601-5. [PubMed: 16237046]  [MGI Ref ID J:119367]

Menachery VD; Yount BL Jr; Josset L; Gralinski LE; Scobey T; Agnihothram S; Katze MG; Baric RS. 2014. Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol 88(8):4251-64. [PubMed: 24478444]  [MGI Ref ID J:213001]

Merkler D; Horvath E; Bruck W; Zinkernagel RM; Del la Torre JC; Pinschewer DD. 2006. 'Viral deja vu' elicits organ-specific immune disease independent of reactivity to self. J Clin Invest 116(5):1254-63. [PubMed: 16604192]  [MGI Ref ID J:108857]

Mignot G; Ullrich E; Bonmort M; Menard C; Apetoh L; Taieb J; Bosisio D; Sozzani S; Ferrantini M; Schmitz J; Mack M; Ryffel B; Bulfone-Paus S; Zitvogel L; Chaput N. 2008. The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. J Immunol 180(10):6477-83. [PubMed: 18453565]  [MGI Ref ID J:134964]

Miyagi T; Gil MP; Wang X; Louten J; Chu WM; Biron CA. 2007. High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med 204(10):2383-96. [PubMed: 17846149]  [MGI Ref ID J:126055]

Mizutani T; Neugebauer N; Putz EM; Moritz N; Simma O; Zebedin-Brandl E; Gotthardt D; Warsch W; Eckelhart E; Kantner HP; Kalinke U; Lienenklaus S; Weiss S; Strobl B; Muller M; Sexl V; Stoiber D. 2012. Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1(7):1027-1037. [PubMed: 23170251]  [MGI Ref ID J:190438]

Mizutani T; Tsuji K; Ebihara Y; Taki S; Ohba Y; Taniguchi T; Honda K. 2008. Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. Exp Hematol 36(3):255-64. [PubMed: 18207304]  [MGI Ref ID J:132617]

Montoya M; Edwards MJ; Reid DM; Borrow P. 2005. Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN. J Immunol 174(4):1851-61. [PubMed: 15699111]  [MGI Ref ID J:96536]

Montoya M; Schiavoni G; Mattei F; Gresser I; Belardelli F; Borrow P; Tough DF. 2002. Type I interferons produced by dendritic cells promote their phenotypic and functional activation. Blood 99(9):3263-71. [PubMed: 11964292]  [MGI Ref ID J:115567]

Mordstein M; Kochs G; Dumoutier L; Renauld JC; Paludan SR; Klucher K; Staeheli P. 2008. Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses. PLoS Pathog 4(9):e1000151. [PubMed: 18787692]  [MGI Ref ID J:162206]

Moro H; Otero DC; Tanabe Y; David M. 2011. T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. PLoS One 6(9):e24972. [PubMed: 21949815]  [MGI Ref ID J:177873]

Mrkic B; Pavlovic J; Rulicke T; Volpe P; Buchholz CJ; Hourcade D; Atkinson JP; Aguzzi A; Cattaneo R. 1998. Measles virus spread and pathogenesis in genetically modified mice. J Virol 72(9):7420-7. [PubMed: 9696838]  [MGI Ref ID J:160878]

Mukherjee P; Woods TA; Moore RA; Peterson KE. 2013. Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death. Immunity 38(4):705-16. [PubMed: 23499490]  [MGI Ref ID J:196200]

Nagarajan UM; Ojcius DM; Stahl L; Rank RG; Darville T. 2005. Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88. J Immunol 175(1):450-60. [PubMed: 15972679]  [MGI Ref ID J:100592]

Nagarajan UM; Prantner D; Sikes JD; Andrews CW Jr; Goodwin AM; Nagarajan S; Darville T. 2008. Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model. Infect Immun 76(10):4642-8. [PubMed: 18663004]  [MGI Ref ID J:140222]

Nagasaka A; Kawane K; Yoshida H; Nagata S. 2010. Apaf-1-independent programmed cell death in mouse development. Cell Death Differ 17(6):931-41. [PubMed: 19960021]  [MGI Ref ID J:186378]

Nakajima S; Hida S; Taki S. 2008. IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1+B220+ NK cells. Biochem Biophys Res Commun 369(4):1139-43. [PubMed: 18339305]  [MGI Ref ID J:134069]

Nakamura S; Davis KM; Weiser JN. 2011. Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice. J Clin Invest 121(9):3657-65. [PubMed: 21841308]  [MGI Ref ID J:178251]

Narendra SC; Chalise JP; Hook N; Magnusson M. 2014. Dendritic cells activated by double-stranded RNA induce arthritis via autocrine type I IFN signaling. J Leukoc Biol 95(4):661-6. [PubMed: 24304616]  [MGI Ref ID J:211874]

Navarini AA; Recher M; Lang KS; Georgiev P; Meury S; Bergthaler A; Flatz L; Bille J; Landmann R; Odermatt B; Hengartner H; Zinkernagel RM. 2006. Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses. Proc Natl Acad Sci U S A 103(42):15535-9. [PubMed: 17030789]  [MGI Ref ID J:115342]

Naves R; Singh SP; Cashman KS; Rowse AL; Axtell RC; Steinman L; Mountz JD; Steele C; De Sarno P; Raman C. 2013. The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol 191(6):2967-77. [PubMed: 23960239]  [MGI Ref ID J:205866]

Nayak D; Johnson KR; Heydari S; Roth TL; Zinselmeyer BH; McGavern DB. 2013. Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system. PLoS Pathog 9(5):e1003395. [PubMed: 23737750]  [MGI Ref ID J:213399]

Negishi H; Miki S; Sarashina H; Taguchi-Atarashi N; Nakajima A; Matsuki K; Endo N; Yanai H; Nishio J; Honda K; Taniguchi T. 2012. Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. Proc Natl Acad Sci U S A 109(51):21016-21. [PubMed: 23213237]  [MGI Ref ID J:193098]

Negishi H; Osawa T; Ogami K; Ouyang X; Sakaguchi S; Koshiba R; Yanai H; Seko Y; Shitara H; Bishop K; Yonekawa H; Tamura T; Kaisho T; Taya C; Taniguchi T; Honda K. 2008. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A 105(51):20446-51. [PubMed: 19074283]  [MGI Ref ID J:142672]

Nguyen KB; Salazar-Mather TP; Dalod MY; Van Deusen JB; Wei XQ; Liew FY; Caligiuri MA; Durbin JE; Biron CA. 2002. Coordinated and distinct roles for IFN-alphabeta, IL-12, and IL-15 regulation of NK cell responses to viral infection. J Immunol 169(8):4279-87. [PubMed: 12370359]  [MGI Ref ID J:79552]

Nickerson KM; Cullen JL; Kashgarian M; Shlomchik MJ. 2013. Exacerbated Autoimmunity in the Absence of TLR9 in MRL.Faslpr Mice Depends on Ifnar1. J Immunol 190(8):3889-94. [PubMed: 23467932]  [MGI Ref ID J:194914]

Notake T; Horisawa S; Sanjo H; Miyagawa S; Hida S; Taki S. 2012. Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors. J Immunol 188(10):4838-45. [PubMed: 22504642]  [MGI Ref ID J:188674]

Nowak M; Kramer B; Haupt M; Papapanou PN; Kebschull J; Hoffmann P; Schmidt-Wolf IG; Jepsen S; Brossart P; Perner S; Kebschull M. 2013. Activation of invariant NK T cells in periodontitis lesions. J Immunol 190(5):2282-91. [PubMed: 23365081]  [MGI Ref ID J:193458]

O'Connell RM; Saha SK; Vaidya SA; Bruhn KW; Miranda GA; Zarnegar B; Perry AK; Nguyen BO; Lane TF; Taniguchi T; Miller JF; Cheng G. 2004. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med 200(4):437-45. [PubMed: 15302901]  [MGI Ref ID J:93927]

Ogolla PS; Portillo JA; White CL; Patel K; Lamb B; Sen GC; Subauste CS. 2013. The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen. PLoS Pathog 9(8):e1003557. [PubMed: 23990781]  [MGI Ref ID J:214498]

Ohkouchi S; Shibata M; Sasaki M; Koike M; Safig P; Peters C; Nagata S; Uchiyama Y. 2013. Biogenesis and proteolytic processing of lysosomal DNase II. PLoS One 8(3):e59148. [PubMed: 23516607]  [MGI Ref ID J:199384]

Ohmori Y; Hamilton TA. 2001. Requirement for STAT1 in LPS-induced gene expression in macrophages. J Leukoc Biol 69(4):598-604. [PubMed: 11310846]  [MGI Ref ID J:124463]

Ohno S; Ono N; Seki F; Takeda M; Kura S; Tsuzuki T; Yanagi Y. 2007. Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. J Virol 81(4):1650-9. [PubMed: 17135325]  [MGI Ref ID J:117810]

Ohshima D; Qin J; Konno H; Hirosawa A; Shiraishi T; Yanai H; Shimo Y; Shinzawa M; Akiyama N; Yamashita R; Nakai K; Akiyama T; Inoue J. 2011. RANK signaling induces interferon-stimulated genes in the fetal thymic stroma. Biochem Biophys Res Commun 408(4):530-6. [PubMed: 21527253]  [MGI Ref ID J:172269]

Olvera-Gomez I; Hamilton SE; Xiao Z; Guimaraes CP; Ploegh HL; Hogquist KA; Wang L; Jameson SC. 2012. Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proc Natl Acad Sci U S A 109(6):2072-7. [PubMed: 22308317]  [MGI Ref ID J:182026]

Ontiveros F; Wilson EB; Livingstone AM. 2011. Type I interferon supports primary CD8+ T-cell responses to peptide-pulsed dendritic cells in the absence of CD4+ T-cell help. Immunology 132(4):549-58. [PubMed: 21255009]  [MGI Ref ID J:172101]

Orgun NN; Mathis MA; Wilson CB; Way SS. 2008. Deviation from a Strong Th1-Dominated to a Modest Th17-Dominated CD4 T Cell Response in the Absence of IL-12p40 and Type I IFNs Sustains Protective CD8 T Cells. J Immunol 180(6):4109-15. [PubMed: 18322221]  [MGI Ref ID J:132929]

Otero DC; Baker DP; David M. 2013. IRF7-Dependent IFN-beta Production in Response to RANKL Promotes Medullary Thymic Epithelial Cell Development. J Immunol 190(7):3289-98. [PubMed: 23440417]  [MGI Ref ID J:194737]

Ou R; Zhou S; Huang L; Moskophidis D. 2001. Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol 75(18):8407-23. [PubMed: 11507186]  [MGI Ref ID J:71214]

Ousman SS; Wang J; Campbell IL. 2005. Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. J Virol 79(12):7514-27. [PubMed: 15919906]  [MGI Ref ID J:98854]

Pace L; Vitale S; Dettori B; Palombi C; La Sorsa V; Belardelli F; Proietti E; Doria G. 2010. APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions. J Immunol 184(11):5969-79. [PubMed: 20427775]  [MGI Ref ID J:161228]

Paget C; Mallevaey T; Speak AO; Torres D; Fontaine J; Sheehan KC; Capron M; Ryffel B; Faveeuw C; Leite de Moraes M; Platt F; Trottein F. 2007. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27(4):597-609. [PubMed: 17950005]  [MGI Ref ID J:126128]

Painz R; Walter I; Kolbe T; Rigler D; Vogl C; Steinborn R; Rulicke T; Helmreich M; Karaghiosoff M; Muller M. 2007. Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo. Immunobiology 212(9-10):863-75. [PubMed: 18086385]  [MGI Ref ID J:140278]

Pallotta MT; Orabona C; Volpi C; Vacca C; Belladonna ML; Bianchi R; Servillo G; Brunacci C; Calvitti M; Bicciato S; Mazza EM; Boon L; Grassi F; Fioretti MC; Fallarino F; Puccetti P; Grohmann U. 2011. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 12(9):870-8. [PubMed: 21804557]  [MGI Ref ID J:176469]

Palomo J; Fauconnier M; Coquard L; Gilles M; Meme S; Szeremeta F; Fick L; Franetich JF; Jacobs M; Togbe D; Beloeil JC; Mazier D; Ryffel B; Quesniaux VF. 2013. Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol 43(10):2683-95. [PubMed: 23780878]  [MGI Ref ID J:201696]

Panchanathan V; Chaudhri G; Karupiah G. 2005. Interferon function is not required for recovery from a secondary poxvirus infection. Proc Natl Acad Sci U S A 102(36):12921-6. [PubMed: 16123129]  [MGI Ref ID J:101427]

Pantel A; Teixeira A; Haddad E; Wood EG; Steinman RM; Longhi MP. 2014. Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol 12(1):e1001759. [PubMed: 24409099]  [MGI Ref ID J:207989]

Park C; Li S; Cha E; Schindler C. 2000. Immune response in Stat2 knockout mice. Immunity 13(6):795-804. [PubMed: 11163195]  [MGI Ref ID J:66564]

Park JM; Ng VH; Maeda S; Rest RF; Karin M. 2004. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 200(12):1647-55. [PubMed: 15611291]  [MGI Ref ID J:95336]

Park K; Scott AL. 2010. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol 88(6):1081-7. [PubMed: 20699362]  [MGI Ref ID J:166647]

Pasieka TJ; Collins L; O'Connor MA; Chen Y; Parker ZM; Berwin BL; Piwnica-Worms DR; Leib DA. 2011. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in alphassgamma interferon receptor-deficient mice. PLoS One 6(9):e24018. [PubMed: 21915277]  [MGI Ref ID J:177699]

Patterson M; Seregin A; Huang C; Kolokoltsova O; Smith J; Miller M; Smith J; Yun N; Poussard A; Grant A; Tigabu B; Walker A; Paessler S. 2014. Rescue of a Recombinant Machupo Virus from Cloned cDNAs and In Vivo Characterization in Interferon (alphabeta/gamma) Receptor Double Knockout Mice. J Virol 88(4):1914-23. [PubMed: 24284323]  [MGI Ref ID J:205274]

Pattison MJ; Mackenzie KF; Arthur JS. 2012. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol 189(6):2784-92. [PubMed: 22904308]  [MGI Ref ID J:189911]

Peine M; Rausch S; Helmstetter C; Frohlich A; Hegazy AN; Kuhl AA; Grevelding CG; Hofer T; Hartmann S; Lohning M. 2013. Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol 11(8):e1001633. [PubMed: 23976880]  [MGI Ref ID J:201585]

Perera GK; Ainali C; Semenova E; Hundhausen C; Barinaga G; Kassen D; Williams AE; Mirza MM; Balazs M; Wang X; Rodriguez RS; Alendar A; Barker J; Tsoka S; Ouyang W; Nestle FO. 2014. Integrative biology approach identifies cytokine targeting strategies for psoriasis. Sci Transl Med 6(223):223ra22. [PubMed: 24523322]  [MGI Ref ID J:213686]

Pham AM; Langlois RA; TenOever BR. 2012. Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination. PLoS Pathog 8(1):e1002465. [PubMed: 22241991]  [MGI Ref ID J:195408]

Phares TW; Ramakrishna C; Parra GI; Epstein A; Chen L; Atkinson R; Stohlman SA; Bergmann CC. 2009. Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity. J Immunol 182(9):5430-8. [PubMed: 19380790]  [MGI Ref ID J:147948]

Pien GC; Nguyen KB; Malmgaard L; Satoskar AR; Biron CA. 2002. A unique mechanism for innate cytokine promotion of T cell responses to viral infections. J Immunol 169(10):5827-37. [PubMed: 12421964]  [MGI Ref ID J:80075]

Pierini R; Juruj C; Perret M; Jones CL; Mangeot P; Weiss DS; Henry T. 2012. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ 19(10):1709-21. [PubMed: 22555457]  [MGI Ref ID J:204790]

Pietras EM; Lakshminarasimhan R; Techner JM; Fong S; Flach J; Binnewies M; Passegue E. 2014. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 211(2):245-62. [PubMed: 24493802]  [MGI Ref ID J:208438]

Pilz A; Kratky W; Stockinger S; Simma O; Kalinke U; Lingnau K; von Gabain A; Stoiber D; Sexl V; Kolbe T; Rulicke T; Muller M; Decker T. 2009. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183(4):2286-93. [PubMed: 19620292]  [MGI Ref ID J:151558]

Pinschewer DD; Flatz L; Steinborn R; Horvath E; Fernandez M; Lutz H; Suter M; Bergthaler A. 2010. Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes. Int Immunol 22(9):749-56. [PubMed: 20584765]  [MGI Ref ID J:163332]

Poeck H; Besch R; Maihoefer C; Renn M; Tormo D; Morskaya SS; Kirschnek S; Gaffal E; Landsberg J; Hellmuth J; Schmidt A; Anz D; Bscheider M; Schwerd T; Berking C; Bourquin C; Kalinke U; Kremmer E; Kato H; Akira S; Meyers R; Hacker G; Neuenhahn M; Busch D;Ruland J; Rothenfusser S; Prinz M; Hornung V; Endres S; Tuting T; Hartmann G. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 14(11):1256-63. [PubMed: 18978796]  [MGI Ref ID J:143226]

Portillo JA; Feliciano LM; Okenka G; Heinzel F; Subauste MC; Subauste CS. 2012. CD40 and tumour necrosis factor-alpha co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages. Immunology 135(2):140-50. [PubMed: 22044243]  [MGI Ref ID J:181390]

Pott J; Mahlakoiv T; Mordstein M; Duerr CU; Michiels T; Stockinger S; Staeheli P; Hornef MW. 2011. IFN-{lambda} determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci U S A 108(19):7944-9. [PubMed: 21518880]  [MGI Ref ID J:172800]

Presti RM; Pollock JL; Dal Canto AJ; O'Guin AK; Virgin HW 4th. 1998. Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels. J Exp Med 188(3):577-88. [PubMed: 9687534]  [MGI Ref ID J:115139]

Prestwood TR; May MM; Plummer EM; Morar MM; Yauch LE; Shresta S. 2012. Trafficking and replication patterns reveal splenic macrophages as major targets of dengue virus in mice. J Virol 86(22):12138-47. [PubMed: 22933295]  [MGI Ref ID J:188919]

Prestwood TR; Morar MM; Zellweger RM; Miller R; May MM; Yauch LE; Lada SM; Shresta S. 2012. Gamma Interferon (IFN-gamma) Receptor Restricts Systemic Dengue Virus Replication and Prevents Paralysis in IFN-alpha/beta Receptor-Deficient Mice. J Virol 86(23):12561-70. [PubMed: 22973027]  [MGI Ref ID J:189016]

Prete F; Catucci M; Labrada M; Gobessi S; Castiello MC; Bonomi E; Aiuti A; Vermi W; Cancrini C; Metin A; Hambleton S; Bredius R; Notarangelo LD; van der Burg M; Kalinke U; Villa A; Benvenuti F. 2013. Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells. J Exp Med 210(2):355-74. [PubMed: 23337808]  [MGI Ref ID J:196418]

Price GE; Gaszewska-Mastarlarz A; Moskophidis D. 2000. The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice. J Virol 74(9):3996-4003. [PubMed: 10756011]  [MGI Ref ID J:61580]

Prinz M; Schmidt H; Mildner A; Knobeloch KP; Hanisch UK; Raasch J; Merkler D; Detje C; Gutcher I; Mages J; Lang R; Martin R; Gold R; Becher B; Bruck W; Kalinke U. 2008. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 28(5):675-86. [PubMed: 18424188]  [MGI Ref ID J:136301]

Puddu P; Carollo MG; Belardelli F; Valenti P; Gessani S. 2007. Role of endogenous interferon and LPS in the immunomodulatory effects of bovine lactoferrin in murine peritoneal macrophages. J Leukoc Biol 82(2):347-53. [PubMed: 17475783]  [MGI Ref ID J:123522]

Pulverer JE; Rand U; Lienenklaus S; Kugel D; Zietara N; Kochs G; Naumann R; Weiss S; Staeheli P; Hauser H; Koster M. 2010. Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol 84(17):8626-38. [PubMed: 20573823]  [MGI Ref ID J:164615]

Qiu H; Fan Y; Joyee AG; Wang S; Han X; Bai H; Jiao L; Van Rooijen N; Yang X. 2008. Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages. J Immunol 181(3):2092-102. [PubMed: 18641348]  [MGI Ref ID J:139231]

Quah HS; Miranda-Hernandez S; Khoo A; Harding A; Fynch S; Elkerbout L; Brodnicki TC; Baxter AG; Kay TW; Thomas HE; Graham KL. 2014. Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice. Diabetes 63(3):1032-40. [PubMed: 24353186]  [MGI Ref ID J:209067]

Quigley M; Huang X; Yang Y. 2008. STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo. J Immunol 180(4):2158-64. [PubMed: 18250422]  [MGI Ref ID J:131918]

Quinn KM; Zak DE; Costa A; Yamamoto A; Kastenmuller K; Hill BJ; Lynn GM; Darrah PA; Lindsay RW; Wang L; Cheng C; Nicosia A; Folgori A; Colloca S; Cortese R; Gostick E; Price DA; Gall JG; Roederer M; Aderem A; Seder RA. 2015. Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. J Clin Invest 125(3):1129-46. [PubMed: 25642773]  [MGI Ref ID J:220556]

Radulovic K; Manta C; Rossini V; Holzmann K; Kestler HA; Wegenka UM; Nakayama T; Niess JH. 2012. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J Immunol 188(4):2001-13. [PubMed: 22250092]  [MGI Ref ID J:181167]

Radwan M; Stiefvater R; Grunert T; Sharif O; Miller I; Marchetti-Deschmann M; Allmaier G; Gemeiner M; Knapp S; Kovarik P; Muller M; Strobl B. 2010. Tyrosine kinase 2 controls IL-1beta production at the translational level. J Immunol 185(6):3544-53. [PubMed: 20713887]  [MGI Ref ID J:163818]

Rajagopal D; Paturel C; Morel Y; Uematsu S; Akira S; Diebold SS. 2010. Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists. Blood 115(10):1949-57. [PubMed: 20065291]  [MGI Ref ID J:158840]

Rau FC; Dieter J; Luo Z; Priest SO; Baumgarth N. 2009. B7-1/2 (CD80/CD86) direct signaling to B cells enhances IgG secretion. J Immunol 183(12):7661-71. [PubMed: 19933871]  [MGI Ref ID J:157479]

Ray JP; Marshall HD; Laidlaw BJ; Staron MM; Kaech SM; Craft J. 2014. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity 40(3):367-77. [PubMed: 24631156]  [MGI Ref ID J:210324]

Rayamajhi M; Humann J; Penheiter K; Andreasen K; Lenz LL. 2010. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med 207(2):327-37. [PubMed: 20123961]  [MGI Ref ID J:157758]

Reboulet RA; Hennies CM; Garcia Z; Nierkens S; Janssen EM. 2010. Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice. J Immunol 185(6):3337-47. [PubMed: 20720209]  [MGI Ref ID J:163539]

Recher M; Lang KS; Hunziker L; Freigang S; Eschli B; Harris NL; Navarini A; Senn BM; Fink K; Lotscher M; Hangartner L; Zellweger R; Hersberger M; Theocharides A; Hengartner H; Zinkernagel RM. 2004. Deliberate removal of T cell help improves virus-neutralizing antibody production. Nat Immunol 5(9):934-42. [PubMed: 15300247]  [MGI Ref ID J:92168]

Reynaud JM; Jegou JF; Welsch JC; Horvat B. 2014. Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9. J Virol 88(10):5421-36. [PubMed: 24574405]  [MGI Ref ID J:214429]

Richer MJ; Nolz JC; Harty JT. 2013. Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling. Immunity 38(1):140-52. [PubMed: 23260194]  [MGI Ref ID J:192617]

Richez C; Yasuda K; Bonegio RG; Watkins AA; Aprahamian T; Busto P; Richards RJ; Liu CL; Cheung R; Utz PJ; Marshak-Rothstein A; Rifkin IR. 2010. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol 184(2):796-806. [PubMed: 20007534]  [MGI Ref ID J:159416]

Rieger T; Merkler D; Gunther S. 2013. Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers. PLoS One 8(8):e72290. [PubMed: 23991083]  [MGI Ref ID J:205958]

Robertson SJ; Lubick KJ; Freedman BA; Carmody AB; Best SM. 2014. Tick-borne flaviviruses antagonize both IRF-1 and type I IFN signaling to inhibit dendritic cell function. J Immunol 192(6):2744-55. [PubMed: 24532583]  [MGI Ref ID J:209906]

Rodriguez-Calvo T; Rojas JM; Martin V; Sevilla N. 2014. Type I interferon limits the capacity of bluetongue virus to infect hematopoietic precursors and dendritic cells in vitro and in vivo. J Virol 88(2):859-67. [PubMed: 24173228]  [MGI Ref ID J:205206]

Romani L; Bistoni F; Perruccio K; Montagnoli C; Gaziano R; Bozza S; Bonifazi P; Bistoni G; Rasi G; Velardi A; Fallarino F; Garaci E; Puccetti P. 2006. Thymosin alpha1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. Blood 108(7):2265-74. [PubMed: 16741252]  [MGI Ref ID J:139477]

Rosas LE; Snider HM; Barbi J; Satoskar AA; Lugo-Villarino G; Keiser T; Papenfuss T; Durbin JE; Radzioch D; Glimcher LH; Satoskar AR. 2006. Cutting edge: STAT1 and T-bet play distinct roles in determining outcome of visceral leishmaniasis caused by Leishmania donovani. J Immunol 177(1):22-5. [PubMed: 16785492]  [MGI Ref ID J:134384]

Rothfuchs AG; Gigliotti D; Palmblad K; Andersson U; Wigzell H; Rottenberg ME. 2001. IFN-alphabeta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J Immunol 167(11):6453-61. [PubMed: 11714812]  [MGI Ref ID J:72825]

Rothfuchs AG; Trumstedt C; Mattei F; Schiavoni G; Hidmark A; Wigzell H; Rottenberg ME. 2006. STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. J Immunol 176(11):6982-90. [PubMed: 16709859]  [MGI Ref ID J:131788]

Rothfuchs AG; Trumstedt C; Wigzell H; Rottenberg ME. 2004. Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on Toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling. J Immunol 172(10):6345-53. [PubMed: 15128825]  [MGI Ref ID J:89856]

Rothlin CV; Ghosh S; Zuniga EI; Oldstone MB; Lemke G. 2007. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131(6):1124-36. [PubMed: 18083102]  [MGI Ref ID J:131447]

Roundy KM; Spangrude G; Weis JJ; Weis JH. 2005. Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs. Int Immunol 17(11):1495-503. [PubMed: 16186160]  [MGI Ref ID J:102222]

Rowe JH; Ertelt JM; Way SS. 2012. Innate IFN-gamma is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol 189(2):876-84. [PubMed: 22711893]  [MGI Ref ID J:189796]

Rubtsov AV; Swanson CL; Troy S; Strauch P; Pelanda R; Torres RM. 2008. TLR Agonists Promote Marginal Zone B Cell Activation and Facilitate T-Dependent IgM Responses. J Immunol 180(6):3882-8. [PubMed: 18322196]  [MGI Ref ID J:132917]

Samuel MA; Diamond MS. 2005. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol 79(21):13350-61. [PubMed: 16227257]  [MGI Ref ID J:102184]

Santiago-Raber ML; Baccala R; Haraldsson KM; Choubey D; Stewart TA; Kono DH; Theofilopoulos AN. 2003. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 197(6):777-88. [PubMed: 12642605]  [MGI Ref ID J:124743]

Satie AP; Mazaud-Guittot S; Seif I; Mahe D; He Z; Jouve G; Jegou B; Dejucq-Rainsford N. 2011. Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility. J Biol Chem 286(26):23280-95. [PubMed: 21515676]  [MGI Ref ID J:174828]

Sato T; Ikeda M; Yotsumoto S; Shimada Y; Higuchi T; Kobayashi H; Fukuda T; Ohashi T; Suda T; Ohteki T. 2013. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121(16):3267-73. [PubMed: 23412092]  [MGI Ref ID J:196707]

Sato T; Onai N; Yoshihara H; Arai F; Suda T; Ohteki T. 2009. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med 15(6):696-700. [PubMed: 19483695]  [MGI Ref ID J:151334]

Sauder C; Hallensleben W; Pagenstecher A; Schneckenburger S; Biro L; Pertlik D; Hausmann J; Suter M; Staeheli P. 2000. Chemokine gene expression in astrocytes of Borna disease virus-infected rats and mice in the absence of inflammation. J Virol 74(19):9267-80. [PubMed: 10982374]  [MGI Ref ID J:64497]

Schirmer SH; Bot PT; Fledderus JO; van der Laan AM; Volger OL; Laufs U; Bohm M; de Vries CJ; Horrevoets AJ; Piek JJ; Hoefer IE; van Royen N. 2010. Blocking interferon {beta} stimulates vascular smooth muscle cell proliferation and arteriogenesis. J Biol Chem 285(45):34677-85. [PubMed: 20736166]  [MGI Ref ID J:167100]

Schleicher U; Liese J; Knippertz I; Kurzmann C; Hesse A; Heit A; Fischer JA; Weiss S; Kalinke U; Kunz S; Bogdan C. 2007. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med 204(4):893-906. [PubMed: 17389237]  [MGI Ref ID J:125611]

Schmidt H; Raasch J; Merkler D; Klinker F; Krauss S; Bruck W; Prinz M. 2009. Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant. Exp Neurol 216(2):306-11. [PubMed: 19121307]  [MGI Ref ID J:147309]

Schneider A; Reichart U; Gerner W; Kolbe T; Saalmuller A; Muller M. 2008. Selective contribution of Tyk2 to cell activation by lipopolysaccharide. FEBS Lett 582(25-26):3681-6. [PubMed: 18845149]  [MGI Ref ID J:141119]

Schoggins JW; Dorner M; Feulner M; Imanaka N; Murphy MY; Ploss A; Rice CM. 2012. Dengue reporter viruses reveal viral dynamics in interferon receptor-deficient mice and sensitivity to interferon effectors in vitro. Proc Natl Acad Sci U S A 109(36):14610-5. [PubMed: 22908290]  [MGI Ref ID J:189890]

Schuessler A; Funk A; Lazear HM; Cooper DA; Torres S; Daffis S; Jha BK; Kumagai Y; Takeuchi O; Hertzog P; Silverman R; Akira S; Barton DJ; Diamond MS; Khromykh AA. 2012. West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response. J Virol 86(10):5708-18. [PubMed: 22379089]  [MGI Ref ID J:186099]

Schwandt T; Schumak B; Gielen GH; Jungerkes F; Schmidbauer P; Klocke K; Staratschek-Jox A; van Rooijen N; Kraal G; Ludwig-Portugall I; Franken L; Wehner S; Kalff JC; Weber O; Kirschning C; Coch C; Kalinke U; Wenzel J; Kurts C; Zawatzky R; Holzmann B; Layland L; Schultze JL; Burgdorf S; den Haan JM; Knolle PA; Limmer A. 2012. Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis. EMBO J 31(1):201-13. [PubMed: 22036947]  [MGI Ref ID J:180238]

Schwarz EM; Badorff C; Hiura TS; Wessely R; Badorff A; Verma IM; Knowlton KU. 1998. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. J Virol 72(7):5654-60. [PubMed: 9621024]  [MGI Ref ID J:120576]

Searles S; Gauss K; Wilkison M; Hoyt TR; Dobrinen E; Meissner N. 2013. Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection. J Immunol 191(7):3884-95. [PubMed: 23975863]  [MGI Ref ID J:205844]

Sedger LM; Hou S; Osvath SR; Glaccum MB; Peschon JJ; van Rooijen N; Hyland L. 2002. Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha. J Immunol 169(11):6193-201. [PubMed: 12444124]  [MGI Ref ID J:118778]

Selin LK; Varga SM; Wong IC; Welsh RM. 1998. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med 188(9):1705-15. [PubMed: 9802982]  [MGI Ref ID J:115234]

Sellin CI; Jegou JF; Renneson J; Druelle J; Wild TF; Marie JC; Horvat B. 2009. Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis. PLoS ONE 4(3):e4948. [PubMed: 19319188]  [MGI Ref ID J:147459]

Seo SU; Kwon HJ; Ko HJ; Byun YH; Seong BL; Uematsu S; Akira S; Kweon MN. 2011. Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog 7(2):e1001304. [PubMed: 21383977]  [MGI Ref ID J:172465]

Seo YJ; Pritzl CJ; Vijayan M; Blake CR; McClain ME; Hahm B. 2012. Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways. J Immunol 188(10):4759-68. [PubMed: 22490865]  [MGI Ref ID J:188687]

Shafiani S; Dinh C; Ertelt JM; Moguche AO; Siddiqui I; Smigiel KS; Sharma P; Campbell DJ; Way SS; Urdahl KB. 2013. Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12. Immunity 38(6):1261-70. [PubMed: 23791647]  [MGI Ref ID J:207578]

Sheikh F; Dickensheets H; Gamero AM; Vogel SN; Donnelly RP. 2014. An essential role for IFN-beta in the induction of IFN-stimulated gene expression by LPS in macrophages. J Leukoc Biol 96(4):591-600. [PubMed: 25024400]  [MGI Ref ID J:220134]

Shen H; Iwasaki A. 2006. A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest 116(8):2237-43. [PubMed: 16878177]  [MGI Ref ID J:113124]

Shen L; Suresh L; Malyavantham K; Kowal P; Xuan J; Lindemann MJ; Ambrus JL Jr. 2013. Different stages of primary Sjogren's syndrome involving lymphotoxin and type 1 IFN. J Immunol 191(2):608-13. [PubMed: 23772034]  [MGI Ref ID J:204953]

Shi C; Jia T; Mendez-Ferrer S; Hohl TM; Serbina NV; Lipuma L; Leiner I; Li MO; Frenette PS; Pamer EG. 2011. Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands. Immunity 34(4):590-601. [PubMed: 21458307]  [MGI Ref ID J:171379]

Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. [PubMed: 16116224]  [MGI Ref ID J:113220]

Shingai M; Inoue N; Okuno T; Okabe M; Akazawa T; Miyamoto Y; Ayata M; Honda K; Kurita-Taniguchi M; Matsumoto M; Ogura H; Taniguchi T; Seya T. 2005. Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection. J Immunol 175(5):3252-61. [PubMed: 16116216]  [MGI Ref ID J:113230]

Shinohara ML; Kim JH; Garcia VA; Cantor H. 2008. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity 29(1):68-78. [PubMed: 18619869]  [MGI Ref ID J:137879]

Shresta S; Kyle JL; Snider HM; Basavapatna M; Beatty PR; Harris E. 2004. Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. J Virol 78(6):2701-10. [PubMed: 14990690]  [MGI Ref ID J:88819]

Shresta S; Sharar KL; Prigozhin DM; Snider HM; Beatty PR; Harris E. 2005. Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice. J Immunol 175(6):3946-54. [PubMed: 16148142]  [MGI Ref ID J:116690]

Siegfried A; Berchtold S; Manncke B; Deuschle E; Reber J; Ott T; Weber M; Kalinke U; Hofer MJ; Hatesuer B; Schughart K; Gailus-Durner V; Fuchs H; Hrabe de Angelis M; Weber F; Hornef MW; Autenrieth IB; Bohn E. 2013. IFIT2 Is an Effector Protein of Type I IFN-Mediated Amplification of Lipopolysaccharide (LPS)-Induced TNF-alpha Secretion and LPS-Induced Endotoxin Shock. J Immunol :. [PubMed: 24014876]  [MGI Ref ID J:199862]

Simma O; Zebedin E; Neugebauer N; Schellack C; Pilz A; Chang-Rodriguez S; Lingnau K; Weisz E; Putz EM; Pickl WF; Felzmann T; Muller M; Decker T; Sexl V; Stoiber D. 2009. Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69(1):203-11. [PubMed: 19118004]  [MGI Ref ID J:143032]

Simmons DP; Canaday DH; Liu Y; Li Q; Huang A; Boom WH; Harding CV. 2010. Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9. J Immunol 185(4):2405-15. [PubMed: 20660347]  [MGI Ref ID J:162861]

Sinha S; Guo Y; Thet S; Yuan D. 2012. IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol 92(4):713-22. [PubMed: 22636319]  [MGI Ref ID J:189565]

Smith JA; Turner MJ; Delay ML; Klenk EI; Sowders DP; Colbert RA. 2008. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur J Immunol 38(5):1194-203. [PubMed: 18412159]  [MGI Ref ID J:134150]

Sporri R; Joller N; Albers U; Hilbi H; Oxenius A. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J Immunol 176(10):6162-71. [PubMed: 16670325]  [MGI Ref ID J:131762]

Springfeld C; von Messling V; Frenzke M; Ungerechts G; Buchholz CJ; Cattaneo R. 2006. Oncolytic efficacy and enhanced safety of measles virus activated by tumor-secreted matrix metalloproteinases. Cancer Res 66(15):7694-700. [PubMed: 16885371]  [MGI Ref ID J:112101]

Srivastava S; Koch MA; Pepper M; Campbell DJ. 2014. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med 211(5):961-74. [PubMed: 24711580]  [MGI Ref ID J:212399]

Staeheli P; Sentandreu M; Pagenstecher A; Hausmann J. 2001. Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells. J Virol 75(17):8216-23. [PubMed: 11483767]  [MGI Ref ID J:70813]

Staehli F; Ludigs K; Heinz LX; Seguin-Estevez Q; Ferrero I; Braun M; Schroder K; Rebsamen M; Tardivel A; Mattmann C; MacDonald HR; Romero P; Reith W; Guarda G; Tschopp J. 2012. NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 188(8):3820-8. [PubMed: 22412192]  [MGI Ref ID J:184076]

Starbeck-Miller GR; Xue HH; Harty JT. 2014. IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo. J Exp Med 211(1):105-20. [PubMed: 24367005]  [MGI Ref ID J:208354]

Stetson DB; Medzhitov R. 2006. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24(1):93-103. [PubMed: 16413926]  [MGI Ref ID J:113316]

Stewart CA; Metheny H; Iida N; Smith L; Hanson M; Steinhagen F; Leighty RM; Roers A; Karp CL; Muller W; Trinchieri G. 2013. Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest :. [PubMed: 24216477]  [MGI Ref ID J:204181]

Stockinger S; Materna T; Stoiber D; Bayr L; Steinborn R; Kolbe T; Unger H; Chakraborty T; Levy DE; Muller M; Decker T. 2002. Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol 169(11):6522-9. [PubMed: 12444163]  [MGI Ref ID J:119320]

Strobl B; Bubic I; Bruns U; Steinborn R; Lajko R; Kolbe T; Karaghiosoff M; Kalinke U; Jonjic S; Muller M. 2005. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. J Immunol 175(6):4000-8. [PubMed: 16148148]  [MGI Ref ID J:116703]

Sugiyama T; Hoshino K; Saito M; Yano T; Sasaki I; Yamazaki C; Akira S; Kaisho T. 2008. Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7. Int Immunol 20(1):1-9. [PubMed: 17981792]  [MGI Ref ID J:128904]

Sukupolvi-Petty S; Austin SK; Engle M; Brien JD; Dowd KA; Williams KL; Johnson S; Rico-Hesse R; Harris E; Pierson TC; Fremont DH; Diamond MS. 2010. Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2. J Virol 84(18):9227-39. [PubMed: 20592088]  [MGI Ref ID J:164610]

Sun K; Ye J; Perez DR; Metzger DW. 2011. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol 186(2):987-93. [PubMed: 21160043]  [MGI Ref ID J:168768]

Swanson CL; Wilson TJ; Strauch P; Colonna M; Pelanda R; Torres RM. 2010. Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med 207(7):1485-500. [PubMed: 20566717]  [MGI Ref ID J:163400]

Tailor P; Tamura T; Kong HJ; Kubota T; Kubota M; Borghi P; Gabriele L; Ozato K. 2007. The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity 27(2):228-39. [PubMed: 17702615]  [MGI Ref ID J:124338]

Takabayshi K; Corr M; Hayashi T; Redecke V; Beck L; Guiney D; Sheppard D; Raz E. 2006. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 24(4):475-87. [PubMed: 16618605]  [MGI Ref ID J:113350]

Takayanagi H; Kim S; Matsuo K; Suzuki H; Suzuki T; Sato K; Yokochi T; Oda H; Nakamura K; Ida N; Wagner EF; Taniguchi T. 2002. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature 416(6882):744-9. [PubMed: 11961557]  [MGI Ref ID J:76097]

Takeda M; Ohno S; Tahara M; Takeuchi H; Shirogane Y; Ohmura H; Nakamura T; Yanagi Y. 2008. Measles viruses possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM knock-in mice. J Virol 82(23):11979-84. [PubMed: 18799577]  [MGI Ref ID J:143100]

Takemura N; Kawasaki T; Kunisawa J; Sato S; Lamichhane A; Kobiyama K; Aoshi T; Ito J; Mizuguchi K; Karuppuchamy T; Matsunaga K; Miyatake S; Mori N; Tsujimura T; Satoh T; Kumagai Y; Kawai T; Standley DM; Ishii KJ; Kiyono H; Akira S; Uematsu S. 2014. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun 5:3492. [PubMed: 24637670]  [MGI Ref ID J:210311]

Tam MA; Wick MJ. 2009. MyD88 and interferon-alpha/beta are differentially required for dendritic cell maturation but dispensable for development of protective memory against Listeria. Immunology 128(3):429-38. [PubMed: 20067542]  [MGI Ref ID J:162279]

Taylor D; Wilkison M; Voyich J; Meissner N. 2011. Prevention of bone marrow cell apoptosis and regulation of hematopoiesis by type I IFNs during systemic responses to pneumocystis lung infection. J Immunol 186(10):5956-67. [PubMed: 21471447]  [MGI Ref ID J:173096]

Tezuka H; Abe Y; Asano J; Sato T; Liu J; Iwata M; Ohteki T. 2011. Prominent Role for Plasmacytoid Dendritic Cells in Mucosal T Cell-Independent IgA Induction. Immunity 34(2):247-57. [PubMed: 21333555]  [MGI Ref ID J:168975]

Toma-Hirano M; Namiki S; Miyatake S; Arai K; Kamogawa-Schifter Y. 2007. Type I interferon regulates pDC maturation and Ly49Q expression. Eur J Immunol 37(10):2707-14. [PubMed: 17823983]  [MGI Ref ID J:125262]

Tsuchiya K; Hara H; Kawamura I; Nomura T; Yamamoto T; Daim S; Dewamitta SR; Shen Y; Fang R; Mitsuyama M. 2010. Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes. J Immunol 185(2):1186-95. [PubMed: 20566831]  [MGI Ref ID J:162019]

Tsushima K; Osawa T; Yanai H; Nakajima A; Takaoka A; Manabe I; Ohba Y; Imai Y; Taniguchi T; Nagai R. 2011. IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension. FASEB J 25(5):1531-43. [PubMed: 21266535]  [MGI Ref ID J:172781]

Tu CL; Crumrine DA; Man MQ; Chang W; Elalieh H; You M; Elias PM; Bikle DD. 2012. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol 132(10):2350-9. [PubMed: 22622426]  [MGI Ref ID J:189566]

Turner J; Orme IM. 2004. The expression of early resistance to an infection with Mycobacterium tuberculosis by old mice is dependent on IFN type II (IFN-gamma) but not IFN type I. Mech Ageing Dev 125(1):1-9. [PubMed: 14706232]  [MGI Ref ID J:121050]

Uhl M; Kepp O; Jusforgues-Saklani H; Vicencio JM; Kroemer G; Albert ML. 2009. Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ 16(7):991-1005. [PubMed: 19229247]  [MGI Ref ID J:164191]

Van Uden JH; Tran CH; Carson DA; Raz E. 2001. Type I interferon is required to mount an adaptive response to immunostimulatory DNA. Eur J Immunol 31(11):3281-90. [PubMed: 11745345]  [MGI Ref ID J:72586]

Vasconcellos R; Braun D; Coutinho A; Demengeot J. 1999. Type I IFN sets the stringency of B cell repertoire selection in the bone marrow. Int Immunol 11(2):279-88. [PubMed: 10069426]  [MGI Ref ID J:204273]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Venkatesh D; Ernandez T; Rosetti F; Batal I; Cullere X; Luscinskas FW; Zhang Y; Stavrakis G; Garcia-Cardena G; Horwitz BH; Mayadas TN. 2013. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment. Immunity 38(5):1025-37. [PubMed: 23623383]  [MGI Ref ID J:203156]

Vladimer GI; Weng D; Paquette SW; Vanaja SK; Rathinam VA; Aune MH; Conlon JE; Burbage JJ; Proulx MK; Liu Q; Reed G; Mecsas JC; Iwakura Y; Bertin J; Goguen JD; Fitzgerald KA; Lien E. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37(1):96-107. [PubMed: 22840842]  [MGI Ref ID J:187388]

Vollstedt S; Arnold S; Schwerdel C; Franchini M; Alber G; Di Santo JP; Ackermann M; Suter M. 2004. Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1. J Virol 78(8):3846-50. [PubMed: 15047800]  [MGI Ref ID J:89128]

Vollstedt S; Franchini M; Alber G; Ackermann M; Suter M. 2001. Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1. J Virol 75(20):9596-600. [PubMed: 11559791]  [MGI Ref ID J:71695]

Vollstedt S; O'Keeffe M; Ryf B; Glanzmann B; Hochrein H; Suter M. 2006. The long-term but not the short-term antiviral effect of IFN-alpha depends on Flt3 ligand and pDC. Eur J Immunol 36(5):1231-40. [PubMed: 16639711]  [MGI Ref ID J:114855]

Walter D; Lier A; Geiselhart A; Thalheimer FB; Huntscha S; Sobotta MC; Moehrle B; Brocks D; Bayindir I; Kaschutnig P; Muedder K; Klein C; Jauch A; Schroeder T; Geiger H; Dick TP; Holland-Letz T; Schmezer P; Lane SW; Rieger MA; Essers MA; Williams DA; Trumpp A; Milsom MD. 2015. Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520(7548):549-52. [PubMed: 25707806]  [MGI Ref ID J:220476]

Wang JH; Li J; Wu Q; Yang P; Pawar RD; Xie S; Timares L; Raman C; Chaplin DD; Lu L; Mountz JD; Hsu HC. 2010. Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol 184(1):442-51. [PubMed: 19949066]  [MGI Ref ID J:159044]

Wang R; Yang B; Zhang D. 2011. Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model. Glia 59(6):946-58. [PubMed: 21446050]  [MGI Ref ID J:171207]

Wang X; Li H; Matte-Martone C; Cui W; Li N; Tan HS; Roopenian D; Shlomchik WD. 2011. Mechanisms of antigen presentation to T cells in murine graft-versus-host disease: cross-presentation and the appearance of cross-presentation. Blood 118(24):6426-37. [PubMed: 21963602]  [MGI Ref ID J:179099]

Way SS; Havenar-Daughton C; Kolumam GA; Orgun NN; Murali-Krishna K. 2007. IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection. J Immunol 178(7):4498-505. [PubMed: 17372008]  [MGI Ref ID J:145140]

Weber E; Finsterbusch K; Lindquist R; Nair S; Lienenklaus S; Gekara NO; Janik D; Weiss S; Kalinke U; Overby AK; Kroger A. 2014. Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses. J Virol 88(21):12202-12. [PubMed: 25122777]  [MGI Ref ID J:217076]

Wei B; Su TT; Dalwadi H; Stephan RP; Fujiwara D; Huang TT; Brewer S; Chen L; Arditi M; Borneman J; Rawlings DJ; Braun J. 2008. Resident enteric microbiota and CD8(+) T cells shape the abundance of marginal zone B cells. Eur J Immunol 38(12):3411-3425. [PubMed: 19009526]  [MGI Ref ID J:141389]

Weighardt H; Jusek G; Mages J; Lang R; Hoebe K; Beutler B; Holzmann B. 2004. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur J Immunol 34(2):558-64. [PubMed: 14768061]  [MGI Ref ID J:115469]

Weighardt H; Kaiser-Moore S; Schlautkotter S; Rossmann-Bloeck T; Schleicher U; Bogdan C; Holzmann B. 2006. Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. J Immunol 177(8):5623-30. [PubMed: 17015750]  [MGI Ref ID J:139431]

Weiss G; Maaetoft-Udsen K; Stifter SA; Hertzog P; Goriely S; Thomsen AR; Paludan SR; Frokiaer H. 2012. MyD88 drives the IFN-beta response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7. J Immunol 189(6):2860-8. [PubMed: 22896628]  [MGI Ref ID J:189947]

Wesley JD; Tessmer MS; Paget C; Trottein F; Brossay L. 2007. A Y chromosome-linked factor impairs NK T development. J Immunol 179(6):3480-7. [PubMed: 17785781]  [MGI Ref ID J:152056]

Whitmire JK; Eam B; Whitton JL. 2009. Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection. Eur J Immunol 39(6):1494-504. [PubMed: 19384870]  [MGI Ref ID J:149483]

Wilkison M; Gauss K; Ran Y; Searles S; Taylor D; Meissner N. 2012. Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to pneumocystis lung infection. Am J Pathol 181(1):151-62. [PubMed: 22626807]  [MGI Ref ID J:185537]

Wilson EB; Yamada DH; Elsaesser H; Herskovitz J; Deng J; Cheng G; Aronow BJ; Karp CL; Brooks DG. 2013. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340(6129):202-7. [PubMed: 23580528]  [MGI Ref ID J:195487]

Wongthida P; Diaz RM; Galivo F; Kottke T; Thompson J; Pulido J; Pavelko K; Pease L; Melcher A; Vile R. 2010. Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer. Cancer Res 70(11):4539-49. [PubMed: 20484025]  [MGI Ref ID J:160688]

Woo AJ; Wieland K; Huang H; Akie TE; Piers T; Kim J; Cantor AB. 2013. Developmental differences in IFN signaling affect GATA1s-induced megakaryocyte hyperproliferation. J Clin Invest :. [PubMed: 23863621]  [MGI Ref ID J:201416]

Wynn JL; Scumpia PO; Winfield RD; Delano MJ; Kelly-Scumpia K; Barker T; Ungaro R; Levy O; Moldawer LL. 2008. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood 112(5):1750-8. [PubMed: 18591384]  [MGI Ref ID J:138885]

Xiao H; Peng Y; Hong Y; Huang L; Guo ZS; Bartlett DL; Fu N; Munn DH; Mellor A; He Y. 2013. Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization. J Immunol 190(11):5866-73. [PubMed: 23610140]  [MGI Ref ID J:204787]

Xiao Z; Casey KA; Jameson SC; Curtsinger JM; Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182(5):2786-94. [PubMed: 19234173]  [MGI Ref ID J:146256]

Xiao Z; Mescher MF; Jameson SC. 2007. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med 204(11):2667-77. [PubMed: 17954566]  [MGI Ref ID J:126126]

Xin L; Vargas-Inchaustegui DA; Raimer SS; Kelly BC; Hu J; Zhu L; Sun J; Soong L. 2010. Type I IFN receptor regulates neutrophil functions and innate immunity to Leishmania parasites. J Immunol 184(12):7047-56. [PubMed: 20483775]  [MGI Ref ID J:161135]

Xu Y; Lee PY; Li Y; Liu C; Zhuang H; Han S; Nacionales DC; Weinstein J; Mathews CE; Moldawer LL; Li SW; Satoh M; Yang LJ; Reeves WH. 2012. Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus. J Immunol 188(8):4113-21. [PubMed: 22422888]  [MGI Ref ID J:184062]

Yamamoto T; Hara H; Tsuchiya K; Sakai S; Fang R; Matsuura M; Nomura T; Sato F; Mitsuyama M; Kawamura I. 2012. Listeria monocytogenes strain-specific impairment of the TetR regulator underlies the drastic increase in cyclic di-AMP secretion and beta interferon-inducing ability. Infect Immun 80(7):2323-32. [PubMed: 22508860]  [MGI Ref ID J:186722]

Yanai H; Chen HM; Inuzuka T; Kondo S; Mak TW; Takaoka A; Honda K; Taniguchi T. 2007. Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci U S A 104(9):3402-7. [PubMed: 17360658]  [MGI Ref ID J:125934]

Yang CW; Unanue ER. 2013. Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process. J Exp Med 210(2):375-87. [PubMed: 23337807]  [MGI Ref ID J:196419]

Yang CY; Vogt TK; Favre S; Scarpellino L; Huang HY; Tacchini-Cottier F; Luther SA. 2014. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc Natl Acad Sci U S A 111(1):E109-18. [PubMed: 24367096]  [MGI Ref ID J:206381]

Yang PL; Althage A; Chung J; Maier H; Wieland S; Isogawa M; Chisari FV. 2010. Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A 107(2):798-802. [PubMed: 20080755]  [MGI Ref ID J:156523]

Yang Q; Stevenson HL; Scott MJ; Ismail N. 2015. Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae. Am J Pathol 185(2):446-61. [PubMed: 25481711]  [MGI Ref ID J:219487]

Yang R; Murillo FM; Cui H; Blosser R; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2004. Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88. J Virol 78(20):11152-60. [PubMed: 15452235]  [MGI Ref ID J:93768]

Yang T; Stark P; Janik K; Wigzell H; Rottenberg ME. 2008. SOCS-1 Protects against Chlamydia pneumoniae-Induced Lethal Inflammation but Hampers Effective Bacterial Clearance. J Immunol 180(6):4040-9. [PubMed: 18322213]  [MGI Ref ID J:132932]

Yasuda K; Richez C; Maciaszek JW; Agrawal N; Akira S; Marshak-Rothstein A; Rifkin IR. 2007. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol 178(11):6876-85. [PubMed: 17513736]  [MGI Ref ID J:147844]

Yauch LE; Prestwood TR; May MM; Morar MM; Zellweger RM; Peters B; Sette A; Shresta S. 2010. CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination. J Immunol 185(9):5405-16. [PubMed: 20870934]  [MGI Ref ID J:165203]

Yoshida H; Okabe Y; Kawane K; Fukuyama H; Nagata S. 2005. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 6(1):49-56. [PubMed: 15568025]  [MGI Ref ID J:94874]

Yoshimi R; Chang TH; Wang H; Atsumi T; Morse HC 3rd; Ozato K. 2009. Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol 182(12):7527-38. [PubMed: 19494276]  [MGI Ref ID J:149298]

Yount JS; Gitlin L; Moran TM; Lopez CB. 2008. MDA5 Participates in the Detection of Paramyxovirus Infection and Is Essential for the Early Activation of Dendritic Cells in Response to Sendai Virus Defective Interfering Particles. J Immunol 180(7):4910-8. [PubMed: 18354215]  [MGI Ref ID J:133372]

Yun NE; Poussard AL; Seregin AV; Walker AG; Smith JK; Aronson JF; Smith JN; Soong L; Paessler S. 2012. Functional interferon system is required for clearance of lassa virus. J Virol 86(6):3389-92. [PubMed: 22238311]  [MGI Ref ID J:181200]

Yun NE; Seregin AV; Walker DH; Popov VL; Walker AG; Smith JN; Miller M; de la Torre JC; Smith JK; Borisevich V; Fair JN; Wauquier N; Grant DS; Bockarie B; Bente D; Paessler S. 2013. Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. J Virol 87(19):10908-11. [PubMed: 23903830]  [MGI Ref ID J:203692]

Zhang L; Yuan S; Cheng G; Guo B. 2011. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 6(12):e28432. [PubMed: 22163016]  [MGI Ref ID J:182267]

Zhang X; Deriaud E; Jiao X; Braun D; Leclerc C; Lo-Man R. 2007. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med 204(5):1107-18. [PubMed: 17485512]  [MGI Ref ID J:125728]

Zhao J; Li K; Wohlford-Lenane C; Agnihothram SS; Fett C; Zhao J; Gale MJ Jr; Baric RS; Enjuanes L; Gallagher T; McCray PB Jr; Perlman S. 2014. Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A 111(13):4970-5. [PubMed: 24599590]  [MGI Ref ID J:207380]

Zhu J; Huang X; Yang Y. 2007. Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways. J Virol 81(7):3170-80. [PubMed: 17229689]  [MGI Ref ID J:153323]

Zhu J; Huang X; Yang Y. 2009. The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice. J Clin Invest 119(8):2388-98. [PubMed: 19587448]  [MGI Ref ID J:152556]

Zhu J; Huang X; Yang Y. 2007. Type I IFN signaling on both B and CD4 T cells is required for protective antibody response to adenovirus. J Immunol 178(6):3505-10. [PubMed: 17339445]  [MGI Ref ID J:144287]

Zietara N; Lyszkiewicz M; Gekara N; Puchalka J; Dos Santos VA; Hunt CR; Pandita TK; Lienenklaus S; Weiss S. 2009. Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70. J Immunol 183(2):1099-109. [PubMed: 19581626]  [MGI Ref ID J:151489]

Zompi S; Santich BH; Beatty PR; Harris E. 2012. Protection from secondary dengue virus infection in a mouse model reveals the role of serotype cross-reactive B and T cells. J Immunol 188(1):404-16. [PubMed: 22131327]  [MGI Ref ID J:180815]

de Paiva LS; Nobrega A; De Melo GO; Hayashi EA; Carvalho V; Rodrigues E Silva PM; Bellio M; Teixeira GP; Rumjanek V; Costa SS; Koatz VL. 2008. Selective blockade of lymphopoiesis induced by kalanchosine dimalate: inhibition of IL-7-dependent proliferation. J Leukoc Biol 83(4):1038-48. [PubMed: 18198209]  [MGI Ref ID J:134053]

del Fresno C; Soulat D; Roth S; Blazek K; Udalova I; Sancho D; Ruland J; Ardavin C. 2013. Interferon-beta production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans. Immunity 38(6):1176-86. [PubMed: 23770228]  [MGI Ref ID J:207582]

van den Broek MF; Muller U; Huang S; Aguet M; Zinkernagel RM. 1995. Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors. J Virol 69(8):4792-6. [PubMed: 7609046]  [MGI Ref ID J:26860]

van den Pol AN; Ding S; Robek MD. 2014. Long-distance interferon signaling within the brain blocks virus spread. J Virol 88(7):3695-704. [PubMed: 24429359]  [MGI Ref ID J:213016]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes. SPF conditions are recommended.
Mating SystemHomozygote x Homozygote         (Female x Male)   16-JUN-14
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Supply Notes

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms of Use

Terms of Use

General Terms and Conditions

For Licensing and Use Restrictions view the link(s) below:
- Notice regarding distribution of this strain.

Contact information

General inquiries regarding Terms of Use

Contracts Administration


JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.