Strain Name:

B6.129S2-Ifnar1tm1Agt/Mmjax

Availability:

Repository- Live     Available at the JAX MMRRC

Use Restrictions Apply, see Terms of Use
Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for information about B6.129S2-Ifnar1tm1Agt/Mmjax MMRRC Stock Number 032045.
Homozygotes are more susceptible to viral infection, have an abnormal NK antitumor response, and reduced bone mass. This mutant mouse strain may be useful in studies of immunological response to infection, and bone homeostasis.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   16-JUN-14
Specieslaboratory mouse
GenerationN6+F12 (10-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Michel Aguet,   Swiss Inst. for Experimental Cancer Res.

Description
Mice that are homozygous for the targeted mutation are viable, fertile, and normal in size. No gene product (mRNA) is detected by Northern blot analysis of homozygous primary embryonic fibroblasts. Mice that are homozygous for this targeted allele lack type I IFN receptor function, exhibit enhanced osteoclastogenesis with decreased bone density, and impaired response to protozoan parasite (Leishmania) infection. NK cell mediated tumor regression does not occur in homozygotes in response to B16 melanoma tumor implant model.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt exon 3. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The mice were backcrossed to C57Bl/6 for at least 5 generations, as reported by the donating investigator.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ifnar1tm1Agt/Ifnar1tm1Agt

        B6.129S2-Ifnar1tm1Agt
  • immune system phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • abnormal response to infection
    • murine cytomegalovirus replication in macrophages is increased greater than 10,000-fold compared to that in wild-type macrophages   (MGI Ref ID J:116703)
    • increased susceptibility to bacterial infection induced morbidity/mortality
      • all mice treated with LPS die unlike control mice   (MGI Ref ID J:199862)
  • decreased interferon-alpha secretion
    • following infection with Leishmania   (MGI Ref ID J:125611)
  • decreased interferon-beta secretion
    • following infection with Leishmania   (MGI Ref ID J:125611)
  • decreased interleukin-6 secretion
    • from bone marrow-derived macrophage stimulated with LPS or E. coli K1 E-R8   (MGI Ref ID J:199862)
  • decreased tumor necrosis factor secretion
    • from bone marrow-derived macrophage stimulated with LPS or E. coli K1 E-R8   (MGI Ref ID J:199862)
  • impaired natural killer cell mediated cytotoxicity
    • natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells   (MGI Ref ID J:118750)
  • tumorigenesis
  • increased tumor growth/size
    • in mice treated with polyI:C the reduction in tumor growth of injected B16 melanoma cells is less than in polyI:C treated control mice   (MGI Ref ID J:118750)
  • hematopoietic system phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • impaired natural killer cell mediated cytotoxicity
    • natural killer cells from polyI:C-treated mice do not display cytotoxicity towards B16 melanoma cells   (MGI Ref ID J:118750)
  • skeleton phenotype
  • abnormal osteoclast morphology
    • osteoclastogenesis is enhanced   (MGI Ref ID J:76097)
  • decreased bone mineral density   (MGI Ref ID J:76097)
  • mortality/aging
  • increased susceptibility to bacterial infection induced morbidity/mortality
    • all mice treated with LPS die unlike control mice   (MGI Ref ID J:199862)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Ifnar1tm1Agt/Ifnar1tm1Agt

        involves: 129S2/SvPas
  • mortality/aging
  • increased susceptibility to viral infection induced morbidity/mortality
    • MCMV-treated mice exhibit a 800-fold lower LD50 compared with similarly treated wild-type mice   (MGI Ref ID J:115139)
  • immune system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
    • there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
  • abnormal cytokine secretion
    • upon viral infection, interferon alpha induction is normal initially, but in later phases does not reach wild-type levels   (MGI Ref ID J:114555)
  • abnormal dendritic cell physiology
    • in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed   (MGI Ref ID J:114555)
    • Ifn beta stimulation of dendritic cells elicits a significantly lower response in mutant cells than in wild-type   (MGI Ref ID J:114555)
    • amplification of dendritic signaling is suppressed in mutant dendritic cells stimulated with poly(I:C); RelA activation is suppressed   (MGI Ref ID J:114555)
    • induction of MHC and costimulatory molecules is abolished in dendritic cells upon infection with Newcastle disease virus (NDC)   (MGI Ref ID J:114555)
    • maturation of dendritic cells is impaired when stimulated by poly(I:C), LPS or NDV, but migration in T cell zone of spleen is not affected   (MGI Ref ID J:114555)
    • stimulatory activity of CD4+ and CD8+ T cells by poly(I:C) is impaired in poly(I:C)-stimulated mutant dendritic cells; stimulatory activity of CD8+ T cells is impaired in the LPS- or CpG-stimulated dendritic cells to a lesser extent than in poly(I:C)-stimulated cells   (MGI Ref ID J:114555)
  • abnormal immunoglobulin level
    • levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus   (MGI Ref ID J:101427)
  • abnormal inflammatory response
    • in mutant dendritic cells, induction of MHC and costimulatory molecules does not occur in response poly(I:C), in contrast to wild-type cells; LPS or CpG-dependent induction of MHC I and costimulatory molecules is also suppressed   (MGI Ref ID J:114555)
    • MHC I induction is severely impaired in response to all three stimuli   (MGI Ref ID J:114555)
  • increased susceptibility to viral infection
    • mice are 100-fold more susceptible to MCMV viral infection than controls   (MGI Ref ID J:81243)
    • increased susceptibility of encephalomyocarditis virus induced lethality   (MGI Ref ID J:137522)
    • increased susceptibility to Ectromelia virus   (MGI Ref ID J:101427)
    • 100% mortality by day 6-12 after primary infection infection   (MGI Ref ID J:101427)
    • elevated virus titers in all organs tested after primary infection but much improved after secondary infections   (MGI Ref ID J:101427)
    • survive secondary infections   (MGI Ref ID J:101427)
    • mice infected with HSV-2 strain 186 exhibit more severe clinical scores of disease (genital lesions, redness and swelling) compared with wild-type mice   (MGI Ref ID J:197569)
    • increased susceptibility to viral infection induced morbidity/mortality
      • MCMV-treated mice exhibit a 800-fold lower LD50 compared with similarly treated wild-type mice   (MGI Ref ID J:115139)
  • vision/eye phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • cardiovascular system phenotype
  • corneal vascularization
    • corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice   (MGI Ref ID J:114973)
  • hematopoietic system phenotype
  • abnormal NK cell physiology
    • NK cells in vivo make much about a fifth less IFN-gamma in response to injections of the TLR9 agonist CpG   (MGI Ref ID J:139001)
    • there is 50% less actively proliferating NK cells in the spleen after MCMV infection compared to controls   (MGI Ref ID J:79552)
    • impaired natural killer cell mediated cytotoxicity
      • NK cells from MCMV-infected mice have 10-fold less cytotoxicity than wild-type NK cells   (MGI Ref ID J:79552)
  • abnormal immunoglobulin level
    • levels of IgG1a, IgG2a and IgG2b neutralizing antibodies are reduced relative to controls after secondary infection with Ectromelia virus   (MGI Ref ID J:101427)

Ifnar1tm1Agt/Ifnar1tm1Agt

        involves: 129S2/SvPas * C57BL/6
  • immune system phenotype
  • altered susceptibility to infection
    • infection with hvPR8 produces high titers of 5x107   (MGI Ref ID J:120938)
    • infection with lvPR8 produces low titers of 5x104   (MGI Ref ID J:120938)

Ifnar1tm1Agt/Ifnar1tm1Agt

        involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
  • immune system phenotype
  • increased susceptibility to viral infection
    • mice infected with Thogoto virus all succumb within 3 days compared to 5 days for littermate controls   (MGI Ref ID J:119783)

Ifnar1tm1Agt/Ifnar1tm1Agt

        involves: 129S2/SvPas * 129S6/SvEvTac
  • immune system phenotype
  • abnormal CD8-positive, alpha-beta T cell physiology
    • the antigen specificity of CD8 T cells to common LCMV-derived peptides differs from controls with a higher percentage being specific for the GP33-41 peptide   (MGI Ref ID J:54482)
  • abnormal interferon-gamma secretion
    • splenic leukocyte production of IFN-gamma is increased 3-fold 8 days after infection with LCMV compared to controls   (MGI Ref ID J:54482)
    • two-thirds of this IFN-gamma production is dependent on CD8 T cells   (MGI Ref ID J:54482)
    • these T cells produce less IFN-gamma on a per cell basis   (MGI Ref ID J:54482)
  • increased circulating interleukin-12 level
    • 3-4 pg/ml of IL-12 heterodimer are present in the serum 1.5- and 3- days after infection with LCMV while no IL-12 is detected at this timepoint in wild-type mice   (MGI Ref ID J:54482)
  • increased susceptibility to viral infection
    • mice have a 2-log higher viral titer in the spleen, and a 4-log higher viral titer in the liver, 4.5 days after infection with LCMV virus   (MGI Ref ID J:54482)
    • mice took much longer to clear virus, around 28 days, compared to 7 days for wild-type mice   (MGI Ref ID J:54482)
  • homeostasis/metabolism phenotype
  • increased circulating interleukin-12 level
    • 3-4 pg/ml of IL-12 heterodimer are present in the serum 1.5- and 3- days after infection with LCMV while no IL-12 is detected at this timepoint in wild-type mice   (MGI Ref ID J:54482)
  • hematopoietic system phenotype
  • abnormal CD8-positive, alpha-beta T cell physiology
    • the antigen specificity of CD8 T cells to common LCMV-derived peptides differs from controls with a higher percentage being specific for the GP33-41 peptide   (MGI Ref ID J:54482)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Endocrine Deficiency Research
Bone/Bone Marrow Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      NK Cell Deficiency

Research Tools
Cancer Research
      tumor immunology
Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ifnar1tm1Agt
Allele Name targeted mutation 1, Michel Aguet
Allele Type Targeted (Null/Knockout)
Common Name(s) A 129; A129; A-; IFN Alpha Ro/o; IFN type I receptor; IFN-IR KO; IFN-IR-; IFN-alpha/betaR-; IFN-alpha/betaR/A129; IFN-alpha/betaR0; IFN-alphabeta-R KO; IFN-alphabetaR-; IFNAR(0); IFNAR-; IFNR-; IFNRA1,-.; IFNRI -; IFNRI KO; Ifnar1-;
Mutation Made ByDr. Michel Aguet,   Swiss Inst. for Experimental Cancer Res.
Strain of Origin129S2/SvPas
Gene Symbol and Name Ifnar1, interferon (alpha and beta) receptor 1
Chromosome 16
Gene Common Name(s) AVP; IFN-alpha-REC; IFN-alpha/betaR; IFNAR; IFNBR; IFRC; Ifar; Ifrc;
Molecular Note A neomycin cassette was inserted into exon 3 at a position corresponding to amino acid 88. [MGI Ref ID J:36115] [MGI Ref ID J:96036]

Genotyping

Genotyping Information

Genotyping Protocols

Ifnar1tm1Agt, Melt Curve Analysis
Ifnar1tm1Agt, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Muller U; Steinhoff U; Reis LF; Hemmi S; Pavlovic J; Zinkernagel RM; Aguet M. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264(5167):1918-21. [PubMed: 8009221]  [MGI Ref ID J:36115]

Additional References

Ifnar1tm1Agt related

Abbas K; Breton J; Picot CR; Quesniaux V; Bouton C; Drapier JC. 2009. Signaling events leading to peroxiredoxin 5 up-regulation in immunostimulated macrophages. Free Radic Biol Med 47(6):794-802. [PubMed: 19540914]  [MGI Ref ID J:152566]

Abe Y; Fujii K; Nagata N; Takeuchi O; Akira S; Oshiumi H; Matsumoto M; Seya T; Koike S. 2012. The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice. J Virol 86(1):185-94. [PubMed: 22072781]  [MGI Ref ID J:178834]

Abril C; Engels M; Liman A; Hilbe M; Albini S; Franchini M; Suter M; Ackermann M. 2004. Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice. J Virol 78(7):3644-53. [PubMed: 15016885]  [MGI Ref ID J:89073]

Agrawal H; Jacob N; Carreras E; Bajana S; Putterman C; Turner S; Neas B; Mathian A; Koss MN; Stohl W; Kovats S; Jacob CO. 2009. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 183(9):6021-9. [PubMed: 19812195]  [MGI Ref ID J:156625]

Aguilar PV; Paessler S; Carrara AS; Baron S; Poast J; Wang E; Moncayo AC; Anishchenko M; Watts D; Tesh RB; Weaver SC. 2005. Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol 79(17):11300-10. [PubMed: 16103182]  [MGI Ref ID J:101624]

Aichele P; Unsoeld H; Koschella M; Schweier O; Kalinke U; Vucikuja S. 2006. CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J Immunol 176(8):4525-9. [PubMed: 16585541]  [MGI Ref ID J:131168]

Akazawa T; Ebihara T; Okuno M; Okuda Y; Shingai M; Tsujimura K; Takahashi T; Ikawa M; Okabe M; Inoue N; Okamoto-Tanaka M; Ishizaki H; Miyoshi J; Matsumoto M; Seya T. 2007. Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A 104(1):252-7. [PubMed: 17190817]  [MGI Ref ID J:118750]

Alazawi W; Heath H; Waters JA; Woodfin A; O'Brien AJ; Scarzello AJ; Ma B; Lopez-Otalora Y; Jacobs M; Petts G; Goldin RD; Nourshargh S; Gamero AM; Foster GR. 2013. Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis. Proc Natl Acad Sci U S A 110(21):8656-61. [PubMed: 23653476]  [MGI Ref ID J:197445]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Ambati BK; Nozaki M; Singh N; Takeda A; Jani PD; Suthar T; Albuquerque RJ; Richter E; Sakurai E; Newcomb MT; Kleinman ME; Caldwell RB; Lin Q; Ogura Y; Orecchia A; Samuelson DA; Agnew DW; St Leger J; Green WR; Mahasreshti PJ; Curiel DT; Kwan D; Marsh H; Ikeda S; Leiper LJ; Collinson JM; Bogdanovich S; Khurana TS; Shibuya M; Baldwin ME; Ferrara N; Gerber HP; De Falco S; Witta J; Baffi JZ; Raisler BJ; Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443(7114):993-7. [PubMed: 17051153]  [MGI Ref ID J:114973]

Andrade RM; Wessendarp M; Portillo JA; Yang JQ; Gomez FJ; Durbin JE; Bishop GA; Subauste CS. 2005. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol 175(9):6014-21. [PubMed: 16237096]  [MGI Ref ID J:119350]

Ank N; Iversen MB; Bartholdy C; Staeheli P; Hartmann R; Jensen UB; Dagnaes-Hansen F; Thomsen AR; Chen Z; Haugen H; Klucher K; Paludan SR. 2008. An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol 180(4):2474-85. [PubMed: 18250457]  [MGI Ref ID J:131989]

Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10):6044-50. [PubMed: 19414755]  [MGI Ref ID J:148244]

Arnold CN; Pirie E; Dosenovic P; McInerney GM; Xia Y; Wang N; Li X; Siggs OM; Karlsson Hedestam GB; Beutler B. 2012. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A :. [PubMed: 22761313]  [MGI Ref ID J:185495]

Asselin-Paturel C; Brizard G; Pin JJ; Briere F; Trinchieri G. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J Immunol 171(12):6466-77. [PubMed: 14662846]  [MGI Ref ID J:86925]

Auerbuch V; Brockstedt DG; Meyer-Morse N; O'Riordan M; Portnoy DA. 2004. Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes. J Exp Med 200(4):527-33. [PubMed: 15302899]  [MGI Ref ID J:93932]

Baban B; Chandler PR; Sharma MD; Pihkala J; Koni PA; Munn DH; Mellor AL. 2009. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 183(4):2475-83. [PubMed: 19635913]  [MGI Ref ID J:151475]

Baccala R; Welch MJ; Gonzalez-Quintial R; Walsh KB; Teijaro JR; Nguyen A; Ng CT; Sullivan BM; Zarpellon A; Ruggeri ZM; de la Torre JC; Theofilopoulos AN; Oldstone MB. 2014. Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci U S A 111(24):8925-30. [PubMed: 24889626]  [MGI Ref ID J:211634]

Baenziger S; Heikenwalder M; Johansen P; Schlaepfer E; Hofer U; Miller RC; Diemand S; Honda K; Kundig TM; Aguzzi A; Speck RF. 2009. Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology. Blood 113(2):377-88. [PubMed: 18824599]  [MGI Ref ID J:144246]

Bahl K; Kim SK; Calcagno C; Ghersi D; Puzone R; Celada F; Selin LK; Welsh RM. 2006. IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 176(7):4284-95. [PubMed: 16547266]  [MGI Ref ID J:129873]

Bald T; Landsberg J; Lopez-Ramos D; Renn M; Glodde N; Jansen P; Gaffal E; Steitz J; Tolba R; Kalinke U; Limmer A; Jonsson G; Holzel M; Tuting T. 2014. Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov 4(6):674-87. [PubMed: 24589924]  [MGI Ref ID J:213428]

Ball EA; Sambo MR; Martins M; Trovoada MJ; Benchimol C; Costa J; Antunes Goncalves L; Coutinho A; Penha-Goncalves C. 2013. IFNAR1 controls progression to cerebral malaria in children and CD8+ T cell brain pathology in Plasmodium berghei-infected mice. J Immunol 190(10):5118-27. [PubMed: 23585679]  [MGI Ref ID J:202560]

Banks TA; Rickert S; Benedict CA; Ma L; Ko M; Meier J; Ha W; Schneider K; Granger SW; Turovskaya O; Elewaut D; Otero D; French AR; Henry SC; Hamilton JD; Scheu S; Pfeffer K; Ware CF. 2005. A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol 174(11):7217-25. [PubMed: 15905567]  [MGI Ref ID J:99001]

Baron ML; Gauchat D; La Motte-Mohs R; Kettaf N; Abdallah A; Michiels T; Zuniga-Pflucker JC; Sekaly RP. 2008. TLR Ligand-Induced Type I IFNs Affect Thymopoiesis. J Immunol 180(11):7134-46. [PubMed: 18490712]  [MGI Ref ID J:136351]

Barton ES; Lutzke ML; Rochford R; Virgin HW 4th. 2005. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol 79(22):14149-60. [PubMed: 16254350]  [MGI Ref ID J:102489]

Behrendt R; Schumann T; Gerbaulet A; Nguyen LA; Schubert N; Alexopoulou D; Berka U; Lienenklaus S; Peschke K; Gibbert K; Wittmann S; Lindemann D; Weiss S; Dahl A; Naumann R; Dittmer U; Kim B; Mueller W; Gramberg T; Roers A. 2013. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep 4(4):689-96. [PubMed: 23972988]  [MGI Ref ID J:202757]

Belhocine K; Monack DM. 2012. Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells. Cell Microbiol 14(1):71-80. [PubMed: 21902795]  [MGI Ref ID J:181382]

Biondo C; Midiri A; Gambuzza M; Gerace E; Falduto M; Galbo R; Bellantoni A; Beninati C; Teti G; Leanderson T; Mancuso G. 2008. IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis. J Immunol 181(1):566-73. [PubMed: 18566423]  [MGI Ref ID J:137360]

Birkner K; Steiner B; Rinkler C; Kern Y; Aichele P; Bogdan C; von Loewenich FD. 2008. The elimination of Anaplasma phagocytophilum requires CD4(+) T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms. Eur J Immunol 38(12):3395-3410. [PubMed: 19039769]  [MGI Ref ID J:141369]

Biswas SK; Bist P; Dhillon MK; Kajiji T; Del Fresno C; Yamamoto M; Lopez-Collazo E; Akira S; Tergaonkar V. 2007. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. J Immunol 179(6):4083-92. [PubMed: 17785847]  [MGI Ref ID J:152028]

Blaauboer SM; Gabrielle VD; Jin L. 2014. MPYS/STING-mediated TNF-alpha, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo. J Immunol 192(1):492-502. [PubMed: 24307739]  [MGI Ref ID J:207163]

Blasius AL; Giurisato E; Cella M; Schreiber RD; Shaw AS; Colonna M. 2006. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 177(5):3260-5. [PubMed: 16920966]  [MGI Ref ID J:139501]

Bochtler P; Kroger A; Schirmbeck R; Reimann J. 2008. Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells. J Immunol 181(3):1633-43. [PubMed: 18641299]  [MGI Ref ID J:137877]

Bode KA; Schroder K; Hume DA; Ravasi T; Heeg K; Sweet MJ; Dalpke AH. 2007. Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122(4):596-606. [PubMed: 17635610]  [MGI Ref ID J:134422]

Bohnet SG; Traynor TR; Majde JA; Kacsoh B; Krueger JM. 2004. Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic hypocretin, prolactin and 2',5'-oligoadenylate synthetase expression. Brain Res 1027(1-2):117-25. [PubMed: 15494163]  [MGI Ref ID J:93528]

Borrow P; Hou S; Gloster S; Ashton M; Hyland L. 2005. Virus infection-associated bone marrow B cell depletion and impairment of humoral immunity to heterologous infection mediated by TNF-alpha/LTalpha. Eur J Immunol 35(2):524-32. [PubMed: 15657949]  [MGI Ref ID J:95618]

Bosmann M; Strobl B; Kichler N; Rigler D; Grailer JJ; Pache F; Murray PJ; Muller M; Ward PA. 2014. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol 96(1):123-31. [PubMed: 24604832]  [MGI Ref ID J:212012]

Bouchlaka MN; Sckisel GD; Chen M; Mirsoian A; Zamora AE; Maverakis E; Wilkins DE; Alderson KL; Hsiao HH; Weiss JM; Monjazeb AM; Hesdorffer C; Ferrucci L; Longo DL; Blazar BR; Wiltrout RH; Redelman D; Taub DD; Murphy WJ. 2013. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med 210(11):2223-37. [PubMed: 24081947]  [MGI Ref ID J:204052]

Bourgeois C; Majer O; Frohner IE; Lesiak-Markowicz I; Hildering KS; Glaser W; Stockinger S; Decker T; Akira S; Muller M; Kuchler K. 2011. Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-{beta} Signaling. J Immunol 186(5):3104-12. [PubMed: 21282509]  [MGI Ref ID J:169378]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes. SPF conditions are recommended.
Mating SystemHomozygote x Homozygote         (Female x Male)   16-JUN-14
Diet Information LabDiet® 5K52/5K67

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Notice regarding distribution of this strain.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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