Strain Name:

B6.Cg-Tg(Sry)2Ei Srydl1Rlb/ArnoJ

Stock Number:

010905

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Common Names: Tdy ml;    
XY- mice with the dl1Rlb allele in the sex determining region of the Y chromosome (Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic characteristics.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.Cg-Tg(Sry)2Ei Srydl1Rob/ArnoJ    (Changed: 29-SEP-09 )
Type Congenic; Mutant Strain; Spontaneous Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN5pN1
Generation Definitions
 
Donating Investigator Arthur P Arnold,   UCLA

Description
The dl1Rlb allele (Y-) is an 11 kb deletion in the sex determining region of the Y chromosome, Sry , XY- mice (with ovaries) with this mutation are phenotypic gonadal females, although they lose germ cells and cease estrous cycling earlier in life. The donating investigator indicates that XY- mice generally infertile on the C57BL/6 background . XX mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males (with testes), although they lack sperm and have smaller testes than normal males. When the two mutations are combined, testis determination is transferred from the Y chromosome to an autosome. Mating the carrier male to a C57BL/6J female produces four "core" genotypes that can be used as a model to investigate relationships between sex chromosome complement (XX or XY) and gonadal type that influences phenotypic characteristics. The four genotypes produced are two types of gonadal females (XX, XY-), and two types of gonadal males (XXTg(Sry), XY- Tg(Sry)).

Development
The Tg(Sry)2Ei transgenic construct was generated by Dr. Robin Lovell-Badge's laboratory from 129-derived 14.6-kb of genomic sequence encoding Sry. In the laboratory of Dr. Eva Eicher at the Jackson Laboratory, the construct was injected into the male pronuclei of fertilized eggs obtained from mating C57BL/6JEi females with C57BL/6JEi-Chr YAKR/J males. The XY transgenic male founder 2 was obtained and maintained by backcrossing transgenic males, obligatorily carrying the consomic Chr YAKR/J, to C57BL/6JEi females.

The dl1Rlb mutation arose spontaneously in a 129S6/SvEvTac derived-CCE embryonic stem cell line treated for retroviral integration. Chimeric male AL430 was mated to females from a C3H based random bred colony carrying the blotchy mutation. XY females produced by these matings were determined to be the result of a spontaneous 11 kb deletion in the Y chromosome and not a proviral insertion. These XY females were either sterile or extremely subfertile, and the continued maintenance of the stock was dependent on fertile XXY females generated by Dr. Paul Burgoyne. This mutation, originally termed Tdym1,, was first characterized in the laboratory of Dr. Robin Lovell-Badge, National Institute of Medical Research, London. The dl1Rlb mutation was transferred to an outbred MF1 background and then eventually combined with the Tg(Sry)2Ei transgene by Paul Burgoyne at NIMR, who mated XXY females (that generate X and XY eggs) to X (Paf labeled) Y transgenic males (that generate a low frequency of 'O' gametes with the Sry transgene) to produce the synthetically fertile XY dl1Rlb:Tg(Sry)2Ei males. When mated to normal XX females, the only fertile male offspring are those with the same genotype as the father. The mutation and transgene were backcrossed together into the C57BL/6J background for a minimum of eighteen generations. Dr. Arthur Arnold, UCLA, donated the strain to the Repository in 2009.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Sry)2Ei allele
006305   B6Ei.Cg-Nr0b1tm1.1Lja Tg(Sry)2Ei Chr YAKR/EiJ
002708   C57BL/6JEi-Tg(Sry)2Ei Chr YAKR/J/EiJ
View Strains carrying   Tg(Sry)2Ei     (2 strains)

View Strains carrying other alleles of Sry     (10 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
46,xx Sex Reversal 1; SRXX1   (SRY)
46,xy Sex Reversal 1; SRXY1   (SRY)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

X/Srydl1Rlb Tg(Sry)2Ei/0

        involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1
  • reproductive system phenotype
  • primary sex reversal
    • chromosomal males that would have developed as fertile females develop as males   (MGI Ref ID J:89312)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Internal/Organ Defects
      gonads

Reproductive Biology Research
Developmental Defects Affecting Gonads

Tg(Sry)2Ei related

Developmental Biology Research
Internal/Organ Defects
      gonads

Reproductive Biology Research
Developmental Defects Affecting Gonads

Research Tools
Developmental Biology Research
Reproductive Biology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Srydl1Rlb
Allele Name sex determining region of Chr Y-deletion 1, Robin Lovell-Badge
Allele Type Spontaneous
Common Name(s) Srydl1Rob; Srym1; Tdym1; Y-; YTdym1; Yq-del;
Strain of Origin129S6/SvEvTac
Gene Symbol and Name Sry, sex determining region of Chr Y
Chromosome Y
Gene Common Name(s) Tdf; Tdy; testis determining factor; testis determining-Y;
Molecular Note This allele contains an 11 kb deletion in the testis-determining region of the gene, including a highly conserved exon encoding the HMG box domain. [MGI Ref ID J:2258]
 
Allele Symbol Tg(Sry)2Ei
Allele Name transgene insertion 2, Eva M Eicher
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) Tg(Sry-129)2Ei;
Strain of OriginC57BL/6JEi-Chr Y
Expressed Gene Sry, sex determining region of Chr Y, mouse, laboratory
Promoter Sry, sex determining region of Chr Y, mouse, laboratory
Molecular Note This transgene consists of an inbred 129 strain derived 14.6 Kb genomic fragment containing the entire Sry open reading frame and no other genes. [MGI Ref ID J:71077]
 

Genotyping

Genotyping Information

Genotyping Protocols

Tg(Sry)Eicher, Standard PCR
Sry, QPCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Arnold AP. 2009. Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues. J Neuroendocrinol 21(4):377-86. [PubMed: 19207816]  [MGI Ref ID J:152290]

Arnold AP; Chen X. 2009. What does the 'four core genotypes' mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol 30(1):1-9. [PubMed: 19028515]  [MGI Ref ID J:152291]

Additional References

Srydl1Rlb related

Arnold AP; Xu J; Grisham W; Chen X; Kim YH; Itoh Y. 2004. Minireview: Sex chromosomes and brain sexual differentiation. Endocrinology 145(3):1057-62. [PubMed: 14670983]  [MGI Ref ID J:88705]

Carruth LL; Reisert I; Arnold AP. 2002. Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5(10):933-4. [PubMed: 12244322]  [MGI Ref ID J:130009]

Chen X; McClusky R; Chen J; Beaven SW; Tontonoz P; Arnold AP; Reue K. 2012. The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet 8(5):e1002709. [PubMed: 22589744]  [MGI Ref ID J:185119]

Cocquet J; Ellis PJ; Yamauchi Y; Mahadevaiah SK; Affara NA; Ward MA; Burgoyne PS. 2009. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol 7(11):e1000244. [PubMed: 19918361]  [MGI Ref ID J:155571]

Cox KH; Rissman EF. 2011. Sex differences in juvenile mouse social behavior are influenced by sex chromosomes and social context. Genes Brain Behav 10(4):465-72. [PubMed: 21414140]  [MGI Ref ID J:185705]

De Vries GJ; Rissman EF; Simerly RB; Yang LY; Scordalakes EM; Auger CJ; Swain A; Lovell-Badge R; Burgoyne PS; Arnold AP. 2002. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci 22(20):9005-14. [PubMed: 12388607]  [MGI Ref ID J:79778]

Durcova-Hills G; Hajkova P; Sullivan S; Barton S; Surani MA; McLaren A. 2006. Influence of sex chromosome constitution on the genomic imprinting of germ cells. Proc Natl Acad Sci U S A 103(30):11184-8. [PubMed: 16847261]  [MGI Ref ID J:111825]

Gatewood JD; Wills A; Shetty S; Xu J; Arnold AP; Burgoyne PS; Rissman EF. 2006. Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci 26(8):2335-42. [PubMed: 16495461]  [MGI Ref ID J:105767]

Gubbay J; Vivian N; Economou A; Jackson D; Goodfellow P; Lovell-Badge R. 1992. Inverted repeat structure of the Sry locus in mice. Proc Natl Acad Sci U S A 89(17):7953-7. [PubMed: 1518820]  [MGI Ref ID J:2258]

Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629]  [MGI Ref ID J:110252]

Kopsida E; Lynn PM; Humby T; Wilkinson LS; Davies W. 2013. Dissociable effects of Sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS One 8(8):e73699. [PubMed: 24009762]  [MGI Ref ID J:206412]

Lovell-Badge R; Robertson E. 1990. XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. Development 109(3):635-46. [PubMed: 2401216]  [MGI Ref ID J:10734]

Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH ; Washburn LL ; McCarrey JR ; Cattanach BM ; Lovell-Badge R ; Burgoyne PS. 1998. Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities. Hum Mol Genet 7(4):715-27. [PubMed: 9499427]  [MGI Ref ID J:46791]

Park JH; Burns-Cusato M; Dominguez-Salazar E; Riggan A; Shetty S; Arnold AP; Rissman EF. 2008. Effects of sex chromosome aneuploidy on male sexual behavior. Genes Brain Behav 7(6):609-17. [PubMed: 18363850]  [MGI Ref ID J:151160]

Sekido R; Bar I; Narvaez V; Penny G; Lovell-Badge R. 2004. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev Biol 274(2):271-9. [PubMed: 15385158]  [MGI Ref ID J:93564]

Szot M; Grigoriev V; Mahadevaiah SK; Ojarikre OA; Toure A; von Glasenapp E; Rattigan A; Turner JM; Elliott DJ; Burgoyne PS. 2003. Does Rbmy have a role in sperm development in mice? Cytogenet Genome Res 103(3-4):330-6. [PubMed: 15051956]  [MGI Ref ID J:89312]

Toure A; Clemente EJ; Ellis P; Mahadevaiah SK; Ojarikre OA; Ball PA; Reynard L; Loveland KL; Burgoyne PS; Affara NA. 2005. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biol 6(12):R102. [PubMed: 16356265]  [MGI Ref ID J:104746]

Toure A; Szot M; Mahadevaiah SK; Rattigan A; Ojarikre OA; Burgoyne PS. 2004. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics 166(2):901-12. [PubMed: 15020475]  [MGI Ref ID J:89616]

Vernet N; Szot M; Mahadevaiah SK; Ellis PJ; Decarpentrie F; Ojarikre OA; Rattigan A; Taketo T; Burgoyne PS. 2014. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Development 141(4):855-66. [PubMed: 24496622]  [MGI Ref ID J:208433]

Wagner CK; Xu J; Pfau JL; Quadros PS; De Vries GJ; Arnold AP. 2004. Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status. Endocrinology 145(3):1046-9. [PubMed: 14645115]  [MGI Ref ID J:88702]

Ward MA; Burgoyne PS. 2006. The Effects of Deletions of the Mouse Y Chromosome Long Arm on Sperm Function--Intracytoplasmic Sperm Injection (ICSI)-Based Analysis. Biol Reprod 74(4):652-8. [PubMed: 16354792]  [MGI Ref ID J:107012]

Yamauchi Y; Riel JM; Stoytcheva Z; Burgoyne PS; Ward MA. 2010. Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage. Genome Biol 11(6):R66. [PubMed: 20573212]  [MGI Ref ID J:179194]

Yamauchi Y; Riel JM; Stoytcheva Z; Ward MA. 2014. Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science 343(6166):69-72. [PubMed: 24263135]  [MGI Ref ID J:205194]

Tg(Sry)2Ei related

Albrecht KH; Young M; Washburn LL; Eicher EM. 2003. Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles. Genetics 164(1):277-88. [PubMed: 12750339]  [MGI Ref ID J:127090]

Carruth LL; Reisert I; Arnold AP. 2002. Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5(10):933-4. [PubMed: 12244322]  [MGI Ref ID J:130009]

Gatewood JD; Wills A; Shetty S; Xu J; Arnold AP; Burgoyne PS; Rissman EF. 2006. Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci 26(8):2335-42. [PubMed: 16495461]  [MGI Ref ID J:105767]

Mahadevaiah SK; Odorisio T; Elliott DJ; Rattigan A; Szot M; Laval SH ; Washburn LL ; McCarrey JR ; Cattanach BM ; Lovell-Badge R ; Burgoyne PS. 1998. Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities. Hum Mol Genet 7(4):715-27. [PubMed: 9499427]  [MGI Ref ID J:46791]

Quinn JJ; Hitchcott PK; Umeda EA; Arnold AP; Taylor JR. 2007. Sex chromosome complement regulates habit formation. Nat Neurosci 10(11):1398-400. [PubMed: 17952068]  [MGI Ref ID J:128462]

Smith-Bouvier DL; Divekar AA; Sasidhar M; Du S; Tiwari-Woodruff SK; King JK; Arnold AP; Singh RR; Voskuhl RR. 2008. A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med 205(5):1099-108. [PubMed: 18443225]  [MGI Ref ID J:136240]

Szot M; Grigoriev V; Mahadevaiah SK; Ojarikre OA; Toure A; von Glasenapp E; Rattigan A; Turner JM; Elliott DJ; Burgoyne PS. 2003. Does Rbmy have a role in sperm development in mice? Cytogenet Genome Res 103(3-4):330-6. [PubMed: 15051956]  [MGI Ref ID J:89312]

Toure A; Szot M; Mahadevaiah SK; Rattigan A; Ojarikre OA; Burgoyne PS. 2004. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics 166(2):901-12. [PubMed: 15020475]  [MGI Ref ID J:89616]

Vernet N; Szot M; Mahadevaiah SK; Ellis PJ; Decarpentrie F; Ojarikre OA; Rattigan A; Taketo T; Burgoyne PS. 2014. The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Development 141(4):855-66. [PubMed: 24496622]  [MGI Ref ID J:208433]

Wagner CK; Xu J; Pfau JL; Quadros PS; De Vries GJ; Arnold AP. 2004. Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status. Endocrinology 145(3):1046-9. [PubMed: 14645115]  [MGI Ref ID J:88702]

Ward MA; Burgoyne PS. 2006. The Effects of Deletions of the Mouse Y Chromosome Long Arm on Sperm Function--Intracytoplasmic Sperm Injection (ICSI)-Based Analysis. Biol Reprod 74(4):652-8. [PubMed: 16354792]  [MGI Ref ID J:107012]

Washburn LL; Albrecht KH; Eicher EM. 2001. C57BL/6J-T-Associated Sex Reversal in Mice Is Caused by Reduced Expression of a Mus domesticus Sry Allele. Genetics 158(4):1675-81. [PubMed: 11514455]  [MGI Ref ID J:71077]

Yamauchi Y; Riel JM; Stoytcheva Z; Burgoyne PS; Ward MA. 2010. Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage. Genome Biol 11(6):R66. [PubMed: 20573212]  [MGI Ref ID J:179194]

Yamauchi Y; Riel JM; Stoytcheva Z; Ward MA. 2014. Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science 343(6166):69-72. [PubMed: 24263135]  [MGI Ref ID J:205194]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhile maintaining a live colony, these mice are bred as carrier male crossed to C57BL/6 female.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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