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| This Hoxa11eGFP knock-in strain expresses Green Fluorescent Protein from the endogenous Hoxa11 (homeo box A11) locus. This mutant mouse strain may be useful in studies of embryonic development and organogenesis. | |||||||||||||||
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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Donating Investigator Deneen Wellik, University of Michigan
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (225 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Hoxa11tm1Dmwe/Hoxa11tm1Dmwe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6This mouse can be used to support research in many areas including:
Neurobiology Research
Fluorescent protein expression in neural tissue
Research Tools
Developmental Biology Research
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Hoxa11tm1Dmwe | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Deneen M Wellik | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Hoxa11eGFP; | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Gene Symbol and Name | Hoxa11, homeo box A11 | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | HOX1; HOX1I; Hox-1.9; Hoxa-11; homeo box-1 cluster, gene 9; | ||
| Molecular Note | An eGFP construct was inserted 18 bp downstream of the start site in exon 1 replacing most of exon 1. This was followed by an SV40 T-antigen stop sequence and a self-excising neo cassette in reverse orientation. Cre mediated excision of the neo cassette occurs in the testes. [MGI Ref ID J:140709] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Valledor AF; Arpa L; Sanchez-Tillo E; Comalada M; Casals C; Xaus J; Caelles C; Lloberas J; Celada A. 2008. IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood 112(8):3274-82. [PubMed: 18682602] [MGI Ref ID J:140209]
Additional References
Hoxa11tm1Dmwe relatedNelson LT; Rakshit S; Sun H; Wellik DM. 2008. Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn 237(11):3410-6. [PubMed: 18942146] [MGI Ref ID J:140709]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice can be bred as heterozygotes. Homozygotes are viable but infertile.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
This strain is currently Under Development for Production.
To register your interest in this strain go to the Strain Interest Form.
Estimated Available for Sale Date:
Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.
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Supply Details
| Standard Supply | Under Development for Distribution Colony |
|---|---|
| Supply Notes |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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