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| The cardiac-specific alpha myosin-heavy chain (Myh6, myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of cre in this transgenic strain. The promoter induces greater than 90% recombination in cardiac muscle cells. | |||||||||||||||
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Hemizygote x Noncarrier (Female x Male) 16-MAR-10 Species laboratory mouse Generation N11+N1F1 (27-AUG-10)
Generation DefinitionsDonating Investigator Michael Schneider, Imperial College London Description
The cardiac-specific murine alpha myosin-heavy chain (Myh6, myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter drives expression of cre in this transgenic strain. Breeding this mouse with another carrying loxP-flanked sequences results in the deletion of the flanked sequences in the offspring. The promoter induces greater than 90% recombination in cardiac muscle cells. No recombination is observed in liver, lung, skeletal muscle (quadriceps), and spleen, or in extraneous cell types in the heart.Development
Cardiac-specific mouse alpha myosin heavy chain promoter drives expression of cre. This strain was created an FVB background then backcrossed to C57BL/6 for ten generations by the donating laboratory.SNP (single nucleotide polymorphism) analysis performed by The Jackson Laboratory revealed that the Donating Investigator used C57BL/6N (4 of 4 markers segregating) in the development of the strain. Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J at least once to establish the colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Myh6-cre)2182Mds allele
011037 FVB-Tg(Myh6-cre)2182Mds/J View Strains carrying Tg(Myh6-cre)2182Mds (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cardiovascular Research
Cre-lox System
Cre-lox System
Cre Recombinase Expression
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Myh6-cre)2182Mds | ||
|---|---|---|---|
| Allele Name | transgene insertion 2182, Michael D Schneider | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | MCH-cre; MHC-Cre; MHCalphaCre; MHCcre; Tg(Myhca-cre)2182Mds; alpha-MHC-Cre+; alphaMhc-Cre; alphaMyHC-Cre; | ||
| Mutation Made By | Michael Schneider, Imperial College London | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | cre recombinase is expressed in cardiac tissue. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Myh6, myosin, heavy polypeptide 6, cardiac muscle, alpha, murine, murine | ||
| Gene Symbol and Name | Tg(Myh6-cre)2182Mds, transgene insertion 2182, Michael D Schneider | ||
| Chromosome | UN | ||
| Gene Common Name(s) | MHC-Cre; MHCalphaCre; MHCcre; Tg(Myhca-cre)2182Mds; alpha-MHC-Cre+; alphaMhc-Cre; alphaMyHC-Cre; | ||
| Driver Note | Myh6 | ||
| Molecular Note | The transgenic construct contained the Myh7 3' untranslated region, the Myhca promoter, Myhca noncoding exons 1 and 2, and the exon 3 splice acceptor site 180 bp upstream and driving the expression of the cre recombinase sequence. The Myhca promoter drives expression in cardiac tissue. [MGI Ref ID J:67908] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Myh6-cre), Melt Curve Analysis
Tg(Myh6-cre), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Agah R; Frenkel PA; French BA; Michael LH; Overbeek PA; Schneider MD. 1997. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest 100(1):169-79. [PubMed: 9202069] [MGI Ref ID J:67908]
Additional References
Tg(Myh6-cre)2182Mds relatedAanhaanen WT; Boukens BJ; Sizarov A; Wakker V; de Gier-de Vries C; van Ginneken AC; Moorman AF; Coronel R; Christoffels VM. 2011. Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest 121(2):534-44. [PubMed: 21266775] [MGI Ref ID J:171828]
Angelis E; Garcia A; Chan SS; Schenke-Layland K; Ren S; Goodfellow SJ; Jordan MC; Roos KP; White RJ; MacLellan WR. 2008. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circ Res 102(10):1222-9. [PubMed: 18420946] [MGI Ref ID J:149022]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Augustus A; Yagyu H; Haemmerle G; Bensadoun A; Vikramadithyan RK; Park SY; Kim JK; Zechner R; Goldberg IJ. 2004. Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem 279(24):25050-7. [PubMed: 15028738] [MGI Ref ID J:90737]
Augustus AS; Buchanan J; Park TS; Hirata K; Noh HL; Sun J; Homma S; D'armiento J; Abel ED; Goldberg IJ. 2006. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem 281(13):8716-23. [PubMed: 16410253] [MGI Ref ID J:110484]
Bergo MO; Lieu HD; Gavino BJ; Ambroziak P; Otto JC; Casey PJ; Walker QM; Young SG. 2004. On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 279(6):4729-36. [PubMed: 14625273] [MGI Ref ID J:87958]
Bjorkegren J; Veniant M; Kim SK; Withycombe SK; Wood PA; Hellerstein MK; Neese RA; Young SG. 2001. Lipoprotein secretion and triglyceride stores in the heart. J Biol Chem 276(42):38511-7. [PubMed: 11481337] [MGI Ref ID J:120416]
Boengler K; Buechert A; Heinen Y; Roeskes C; Hilfiker-Kleiner D; Heusch G; Schulz R. 2008. Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res 102(1):131-5. [PubMed: 17967780] [MGI Ref ID J:141572]
Bubikat A; De Windt LJ; Zetsche B; Fabritz L; Sickler H; Eckardt D; Godecke A; Baba HA; Kuhn M. 2005. Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J Biol Chem 280(22):21594-9. [PubMed: 15793309] [MGI Ref ID J:99909]
Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; Vandusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W. 2013. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development 140(9):1946-57. [PubMed: 23571217] [MGI Ref ID J:195489]
Chen JF; Murchison EP; Tang R; Callis TE; Tatsuguchi M; Deng Z; Rojas M; Hammond SM; Schneider MD; Selzman CH; Meissner G; Patterson C; Hannon GJ; Wang DZ. 2008. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 105(6):2111-6. [PubMed: 18256189] [MGI Ref ID J:131962]
Chen JW; Zhou B; Yu QC; Shin SJ; Jiao K; Schneider MD; Baldwin HS; Bergelson JM. 2006. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res 98(7):923-30. [PubMed: 16543498] [MGI Ref ID J:121400]
Cheng L; Ding G; Qin Q; Huang Y; Lewis W; He N; Evans RM; Schneider MD; Brako FA; Xiao Y; Chen YE; Yang Q. 2004. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 10(11):1245-50. [PubMed: 15475963] [MGI Ref ID J:94021]
Danik SB; Liu F; Zhang J; Suk HJ; Morley GE; Fishman GI; Gutstein DE. 2004. Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res 95(10):1035-41. [PubMed: 15499029] [MGI Ref ID J:103851]
Danik SB; Rosner G; Lader J; Gutstein DE; Fishman GI; Morley GE. 2008. Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts. FASEB J 22(4):1204-12. [PubMed: 17984180] [MGI Ref ID J:134898]
Del Re DP; Matsuda T; Zhai P; Gao S; Clark GJ; Van Der Weyden L; Sadoshima J. 2010. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J Clin Invest 120(10):3555-67. [PubMed: 20890045] [MGI Ref ID J:165327]
Ding G; Fu M; Qin Q; Lewis W; Kim HW; Fukai T; Bacanamwo M; Chen YE; Schneider MD; Mangelsdorf DJ; Evans RM; Yang Q. 2007. Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage. Cardiovasc Res 76(2):269-79. [PubMed: 17678635] [MGI Ref ID J:162726]
Dobrowolski R; Sasse P; Schrickel JW; Watkins M; Kim JS; Rackauskas M; Troatz C; Ghanem A; Tiemann K; Degen J; Bukauskas FF; Civitelli R; Lewalter T; Fleischmann BK; Willecke K. 2008. The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet 17(4):539-54. [PubMed: 18003637] [MGI Ref ID J:132032]
Duncan JG; Bharadwaj KG; Fong JL; Mitra R; Sambandam N; Courtois MR; Lavine KJ; Goldberg IJ; Kelly DP. 2010. Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators. Circulation 121(3):426-35. [PubMed: 20065164] [MGI Ref ID J:168445]
Eckardt D; Kirchhoff S; Kim JS; Degen J; Theis M; Ott T; Wiesmann F; Doevendans PA; Lamers WH; de Bakker JM; van Rijen HV; Schneider MD; Willecke K. 2006. Cardiomyocyte-restricted deletion of connexin43 during mouse development. J Mol Cell Cardiol 41(6):963-71. [PubMed: 16963078] [MGI Ref ID J:118103]
Eckardt D; Theis M; Doring B; Speidel D; Willecke K; Ott T. 2004. Spontaneous ectopic recombination in cell-type-specific Cre mice removes loxP-flanked marker cassettes in vivo. Genesis 38(4):159-65. [PubMed: 15083516] [MGI Ref ID J:90577]
Engleka KA; Wu M; Zhang M; Antonucci NB; Epstein JA. 2007. Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol 311(2):524-37. [PubMed: 17927973] [MGI Ref ID J:127545]
Fielitz J; Kim MS; Shelton JM; Qi X; Hill JA; Richardson JA; Bassel-Duby R; Olson EN. 2008. Requirement of protein kinase D1 for pathological cardiac remodeling. Proc Natl Acad Sci U S A 105(8):3059-63. [PubMed: 18287012] [MGI Ref ID J:132803]
Frank M; Eiberger B; Janssen-Bienhold U; de Sevilla Muller LP; Tjarks A; Kim JS; Maschke S; Dobrowolski R; Sasse P; Weiler R; Fleischmann BK; Willecke K. 2010. Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart. J Cell Sci 123(Pt 20):3605-15. [PubMed: 20930146] [MGI Ref ID J:182927]
Freund C; Schmidt-Ullrich R; Baurand A; Dunger S; Schneider W; Loser P; El-Jamali A; Dietz R; Scheidereit C; Bergmann MW. 2005. Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo. Circulation 111(18):2319-25. [PubMed: 15870116] [MGI Ref ID J:111645]
Garcia-Gras E; Lombardi R; Giocondo MJ; Willerson JT; Schneider MD; Khoury DS; Marian AJ. 2006. Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest 116(7):2012-21. [PubMed: 16823493] [MGI Ref ID J:111713]
Gaussin V; Van de Putte T; Mishina Y; Hanks MC; Zwijsen A; Huylebroeck D; Behringer RR; Schneider MD. 2002. Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A 99(5):2878-83. [PubMed: 11854453] [MGI Ref ID J:75084]
Goodman MD; Koch SE; Afzal MR; Butler KL. 2010. STAT SUBTYPE SPECIFICITY AND ISCHEMIC PRECONDITIONING IN MICE: IS STAT-3 ENOUGH? Am J Physiol Heart Circ Physiol :. [PubMed: 21131482] [MGI Ref ID J:167215]
Goodman MD; Koch SE; Fuller-Bicer GA; Butler KL. 2008. Regulating RISK: a role for JAK-STAT signaling in postconditioning? Am J Physiol Heart Circ Physiol 295(4):H1649-56. [PubMed: 18708442] [MGI Ref ID J:141315]
Goonasekera SA; Hammer K; Auger-Messier M; Bodi I; Chen X; Zhang H; Reiken S; Elrod JW; Correll RN; York AJ; Sargent MA; Hofmann F; Moosmang S; Marks AR; Houser SR; Bers DM; Molkentin JD. 2012. Decreased cardiac L-type Ca(2)(+) channel activity induces hypertrophy and heart failure in mice. J Clin Invest 122(1):280-90. [PubMed: 22133878] [MGI Ref ID J:184413]
Gotthardt M; Hammer RE; Hubner N; Monti J; Witt CC; McNabb M; Richardson JA; Granzier H; Labeit S; Herz J. 2003. Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem 278(8):6059-65. [PubMed: 12464612] [MGI Ref ID J:81993]
Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G. 2006. Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-8. [PubMed: 16354690] [MGI Ref ID J:104114]
Grueter CE; van Rooij E; Johnson BA; DeLeon SM; Sutherland LB; Qi X; Gautron L; Elmquist JK; Bassel-Duby R; Olson EN. 2012. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 149(3):671-83. [PubMed: 22541436] [MGI Ref ID J:186193]
Gutstein DE; Morley GE; Fishman GI. 2001. Conditional gene targeting of connexin43: exploring the consequences of gap junction remodeling in the heart. Cell Commun Adhes 8(4-6):345-8. [PubMed: 12064616] [MGI Ref ID J:113085]
Gutstein DE; Morley GE; Tamaddon H; Vaidya D; Schneider MD; Chen J; Chien KR; Stuhlmann H; Fishman GI. 2001. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res 88(3):333-9. [PubMed: 11179202] [MGI Ref ID J:91971]
Harding P; Yang XP; Yang J; Shesely E; He Q; LaPointe MC. 2010. Gene expression profiling of dilated cardiomyopathy in older male EP4 knockout mice. Am J Physiol Heart Circ Physiol 298(2):H623-32. [PubMed: 20008274] [MGI Ref ID J:158439]
Hardy WR; Li L; Wang Z; Sedy J; Fawcett J; Frank E; Kucera J; Pawson T. 2007. Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science 317(5835):251-6. [PubMed: 17626887] [MGI Ref ID J:122927]
Hilfiker-Kleiner D; Hilfiker A; Fuchs M; Kaminski K; Schaefer A; Schieffer B; Hillmer A; Schmiedl A; Ding Z; Podewski E; Podewski E; Poli V; Schneider MD; Schulz R; Park JK; Wollert KC; Drexler H. 2004. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res 95(2):187-95. [PubMed: 15192020] [MGI Ref ID J:99961]
Hilfiker-Kleiner D; Kaminski K; Podewski E; Bonda T; Schaefer A; Sliwa K; Forster O; Quint A; Landmesser U; Doerries C; Luchtefeld M; Poli V; Schneider MD; Balligand JL; Desjardins F; Ansari A; Struman I; Nguyen NQ; Zschemisch NH; Klein G; Heusch G; Schulz R; Hilfiker A; Drexler H. 2007. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell 128(3):589-600. [PubMed: 17289576] [MGI Ref ID J:141591]
Hilfiker-Kleiner D; Shukla P; Klein G; Schaefer A; Stapel B; Hoch M; Muller W; Scherr M; Theilmeier G; Ernst M; Hilfiker A; Drexler H. 2010. Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction. Circulation 122(2):145-55. [PubMed: 20585009] [MGI Ref ID J:178593]
Hoch M; Fischer P; Stapel B; Missol-Kolka E; Sekkali B; Scherr M; Favret F; Braun T; Eder M; Schuster-Gossler K; Gossler A; Hilfiker A; Balligand JL; Drexler H; Hilfiker-Kleiner D. 2011. Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell 9(2):131-43. [PubMed: 21816364] [MGI Ref ID J:175859]
Holtwick R; van Eickels M; Skryabin BV; Baba HA; Bubikat A; Begrow F; Schneider MD; Garbers DL; Kuhn M. 2003. Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest 111(9):1399-407. [PubMed: 12727932] [MGI Ref ID J:83298]
Hoogaars WM; Engel A; Brons JF; Verkerk AO; de Lange FJ; Wong LY; Bakker ML; Clout DE; Wakker V; Barnett P; Ravesloot JH; Moorman AF; Verheijck EE; Christoffels VM. 2007. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev 21(9):1098-112. [PubMed: 17473172] [MGI Ref ID J:121230]
Hsu CP; Zhai P; Yamamoto T; Maejima Y; Matsushima S; Hariharan N; Shao D; Takagi H; Oka S; Sadoshima J. 2010. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 122(21):2170-82. [PubMed: 21060073] [MGI Ref ID J:179477]
Huang H; Yanagisawa M; Kisanuki YY; Jelicks LA; Chandra M; Factor SM; Wittner M; Weiss LM; Pestell RG; Shtutin V; Shirani J; Tanowitz HB. 2002. Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond) 103 Suppl 48:263S-266S. [PubMed: 12193100] [MGI Ref ID J:96386]
Huang J; Min Lu M; Cheng L; Yuan LJ; Zhu X; Stout AL; Chen M; Li J; Parmacek MS. 2009. Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A 106(44):18734-9. [PubMed: 19850880] [MGI Ref ID J:154666]
Jacoby JJ; Kalinowski A; Liu MG; Zhang SS; Gao Q; Chai GX; Ji L; Iwamoto Y; Li E; Schneider M; Russell KS; Fu XY. 2003. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 100(22):12929-34. [PubMed: 14566054] [MGI Ref ID J:86400]
Kanazawa H; Ieda M; Kimura K; Arai T; Kawaguchi-Manabe H; Matsuhashi T; Endo J; Sano M; Kawakami T; Kimura T; Monkawa T; Hayashi M; Iwanami A; Okano H; Okada Y; Ishibashi-Ueda H; Ogawa S; Fukuda K. 2010. Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. J Clin Invest 120(2):408-21. [PubMed: 20051627] [MGI Ref ID J:156687]
Kedzierski RM; Grayburn PA; Kisanuki YY; Williams CS; Hammer RE; Richardson JA; Schneider MD; Yanagisawa M. 2003. Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol 23(22):8226-32. [PubMed: 14585980] [MGI Ref ID J:86476]
Kilic A; Bubikat A; Gassner B; Baba HA; Kuhn M. 2007. Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling. Endocrinology 148(9):4162-9. [PubMed: 17510245] [MGI Ref ID J:129491]
Kilic A; Velic A; De Windt LJ; Fabritz L; Voss M; Mitko D; Zwiener M; Baba HA; van Eickels M; Schlatter E; Kuhn M. 2005. Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation 112(15):2307-17. [PubMed: 16216978] [MGI Ref ID J:116814]
Kimura TE; Jin J; Zi M; Prehar S; Liu W; Oceandy D; Abe J; Neyses L; Weston AH; Cartwright EJ; Wang X. 2010. Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ Res 106(5):961-70. [PubMed: 20075332] [MGI Ref ID J:170874]
Kinouchi K; Ichihara A; Sano M; Sun-Wada GH; Wada Y; Kurauchi-Mito A; Bokuda K; Narita T; Oshima Y; Sakoda M; Tamai Y; Sato H; Fukuda K; Itoh H. 2010. The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes. Circ Res 107(1):30-4. [PubMed: 20570919] [MGI Ref ID J:165020]
Klaiber M; Dankworth B; Kruse M; Hartmann M; Nikolaev VO; Yang RB; Volker K; Gassner B; Oberwinkler H; Feil R; Freichel M; Groschner K; Skryabin BV; Frantz S; Birnbaumer L; Pongs O; Kuhn M. 2011. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A 108(45):18500-5. [PubMed: 22027011] [MGI Ref ID J:180246]
Kontaridis MI; Yang W; Bence KK; Cullen D; Wang B; Bodyak N; Ke Q; Hinek A; Kang PM; Liao R; Neel BG. 2008. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 117(11):1423-35. [PubMed: 18316486] [MGI Ref ID J:148445]
Kratsios P; Catela C; Salimova E; Huth M; Berno V; Rosenthal N; Mourkioti F. 2010. Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. Circ Res 106(3):559-72. [PubMed: 20007915] [MGI Ref ID J:170885]
Kratsios P; Huth M; Temmerman L; Salimova E; Al Banchaabouchi M; Sgoifo A; Manghi M; Suzuki K; Rosenthal N; Mourkioti F. 2010. Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes. Circ Res 106(1):133-44. [PubMed: 19850942] [MGI Ref ID J:170139]
Kuroda J; Ago T; Matsushima S; Zhai P; Schneider MD; Sadoshima J. 2010. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A 107(35):15565-70. [PubMed: 20713697] [MGI Ref ID J:163751]
Kurosaka S; Leu NA; Pavlov I; Han X; Ribeiro PA; Xu T; Bunte R; Saha S; Wang J; Cornachione A; Mai W; Yates JR 3rd; Rassier DE; Kashina A. 2012. Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy. J Mol Cell Cardiol 53(3):333-41. [PubMed: 22626847] [MGI Ref ID J:186647]
Lai L; Leone TC; Zechner C; Schaeffer PJ; Kelly SM; Flanagan DP; Medeiros DM; Kovacs A; Kelly DP. 2008. Transcriptional coactivators PGC-1{alpha} and PGC-l{beta} control overlapping programs required for perinatal maturation of the heart. Genes Dev 22(14):1948-61. [PubMed: 18628400] [MGI Ref ID J:137598]
Lee SY; Kim JR; Hu Y; Khan R; Kim SJ; Bharadwaj KG; Davidson MM; Choi CS; Shin KO; Lee YM; Park WJ; Park IS; Jiang XC; Goldberg IJ; Park TS. 2012. Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction. J Biol Chem 287(22):18429-39. [PubMed: 22493506] [MGI Ref ID J:185614]
Levkau B; Schafers M; Wohlschlaeger J; von Wnuck Lipinski K; Keul P; Hermann S; Kawaguchi N; Kirchhof P; Fabritz L; Stypmann J; Stegger L; Flogel U; Schrader J; Fischer JW; Hsieh P; Ou YL; Mehrhof F; Tiemann K; Ghanem A; Matus M; Neumann J; Heusch G; Schmid KW; Conway EM; Baba HA. 2008. Survivin determines cardiac function by controlling total cardiomyocyte number. Circulation 117(12):1583-93. [PubMed: 18332262] [MGI Ref ID J:148443]
Li D; Liu Y; Maruyama M; Zhu W; Chen H; Zhang W; Reuter S; Lin SF; Haneline LS; Field LJ; Chen PS; Shou W. 2011. Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet 20(23):4582-96. [PubMed: 21880664] [MGI Ref ID J:177567]
Li D; Niu Z; Yu W; Qian Y; Wang Q; Li Q; Yi Z; Luo J; Wu X; Wang Y; Schwartz RJ; Liu M. 2009. SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. Nucleic Acids Res 37(21):7059-71. [PubMed: 19783823] [MGI Ref ID J:173014]
Li Y; Cheng L; Qin Q; Liu J; Lo WK; Brako LA; Yang Q. 2009. High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. J Mol Cell Cardiol 47(4):536-43. [PubMed: 19595695] [MGI Ref ID J:156561]
Li Y; Hiroi Y; Ngoy S; Okamoto R; Noma K; Wang CY; Wang HW; Zhou Q; Radtke F; Liao R; Liao JK. 2011. Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation 123(8):866-76. [PubMed: 21321153] [MGI Ref ID J:183752]
Li Y; Yin R; Liu J; Wang P; Wu S; Luo J; Zhelyabovska O; Yang Q. 2009. Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart. J Mol Cell Cardiol 46(6):876-82. [PubMed: 19265701] [MGI Ref ID J:157147]
Liem DA; Zhao P; Angelis E; Chan SS; Zhang J; Wang G; Berthet C; Kaldis P; Ping P; MacLellan WR. 2008. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol 45(5):610-6. [PubMed: 18692063] [MGI Ref ID J:142766]
Lim BK; Xiong D; Dorner A; Youn TJ; Yung A; Liu TI; Gu Y; Dalton ND; Wright AT; Evans SM; Chen J; Peterson KL; McCulloch AD; Yajima T; Knowlton KU. 2008. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest 118(8):2758-70. [PubMed: 18636119] [MGI Ref ID J:140870]
Lisewski U; Shi Y; Wrackmeyer U; Fischer R; Chen C; Schirdewan A; Juttner R; Rathjen F; Poller W; Radke MH; Gotthardt M. 2008. The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med 205(10):2369-79. [PubMed: 18794341] [MGI Ref ID J:140109]
Liu Y; Korte FS; Moussavi-Harami F; Yu M; Razumova M; Regnier M; Chin MT. 2012. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol 302(9):H1860-70. [PubMed: 22408025] [MGI Ref ID J:186570]
Lombardi R; Dong J; Rodriguez G; Bell A; Leung TK; Schwartz RJ; Willerson JT; Brugada R; Marian AJ. 2009. Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res 104(9):1076-84. [PubMed: 19359597] [MGI Ref ID J:164770]
Lubkemeier I; Requardt RP; Lin X; Sasse P; Andrie R; Schrickel JW; Chkourko H; Bukauskas FF; Kim JS; Frank M; Malan D; Zhang J; Wirth A; Dobrowolski R; Mohler PJ; Offermanns S; Fleischmann BK; Delmar M; Willecke K. 2013. Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels. Basic Res Cardiol 108(3):348. [PubMed: 23558439] [MGI Ref ID J:194957]
Ma Q; Zhou B; Pu WT. 2008. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol 323(1):98-104. [PubMed: 18775691] [MGI Ref ID J:141152]
Ma X; Takeda K; Singh A; Yu ZX; Zerfas P; Blount A; Liu C; Towbin JA; Schneider MD; Adelstein RS; Wei Q. 2009. Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice. Circ Res 105(11):1102-9. [PubMed: 19815823] [MGI Ref ID J:170148]
MacLellan WR; Garcia A; Oh H; Frenkel P; Jordan MC; Roos KP; Schneider MD. 2005. Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb. Mol Cell Biol 25(6):2486-97. [PubMed: 15743840] [MGI Ref ID J:97589]
Maillet M; Davis J; Auger-Messier M; York A; Osinska H; Piquereau J; Lorenz JN; Robbins J; Ventura-Clapier R; Molkentin JD. 2010. Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function. J Biol Chem 285(9):6716-24. [PubMed: 20037164] [MGI Ref ID J:160029]
Malester B; Tong X; Ghiu I; Kontogeorgis A; Gutstein DE; Xu J; Hendricks-Munoz KD; Coetzee WA. 2007. Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. FASEB J 21(9):2162-72. [PubMed: 17341678] [MGI Ref ID J:134852]
Maruyama M; Li BY; Chen H; Xu X; Song LS; Guatimosim S; Zhu W; Yong W; Zhang W; Bu G; Lin SF; Fishbein MC; Lederer WJ; Schild JH; Field LJ; Rubart M; Chen PS; Shou W. 2011. FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res 108(9):1042-52. [PubMed: 21372286] [MGI Ref ID J:183588]
Matus M; Lewin G; Stumpel F; Buchwalow IB; Schneider MD; Schutz G; Schmitz W; Muller FU. 2007. Cardiomyocyte-specific inactivation of transcription factor CREB in mice. FASEB J 21(8):1884-92. [PubMed: 17307839] [MGI Ref ID J:134856]
McDermott-Roe C; Ye J; Ahmed R; Sun XM; Serafin A; Ware J; Bottolo L; Muckett P; Canas X; Zhang J; Rowe GC; Buchan R; Lu H; Braithwaite A; Mancini M; Hauton D; Marti R; Garcia-Arumi E; Hubner N; Jacob H; Serikawa T; Zidek V; Papousek F; Kolar F; Cardona M; Ruiz-Meana M; Garcia-Dorado D; Comella JX; Felkin LE; Barton PJ; Arany Z; Pravenec M; Petretto E; Sanchis D; Cook SA. 2011. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature 478(7367):114-8. [PubMed: 21979051] [MGI Ref ID J:177433]
McFadden DG; Barbosa AC; Richardson JA; Schneider MD; Srivastava D; Olson EN. 2005. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132(1):189-201. [PubMed: 15576406] [MGI Ref ID J:94514]
Misra C; Sachan N; McNally CR; Koenig SN; Nichols HA; Guggilam A; Lucchesi PA; Pu WT; Srivastava D; Garg V. 2012. Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. PLoS Genet 8(5):e1002690. [PubMed: 22589735] [MGI Ref ID J:185124]
Moga MA; Nakamura T; Robbins J. 2008. Genetic approaches for changing the heart and dissecting complex syndromes. J Mol Cell Cardiol 45(2):148-55. [PubMed: 18601931] [MGI Ref ID J:139282]
Montgomery RL; Davis CA; Potthoff MJ; Haberland M; Fielitz J; Qi X; Hill JA; Richardson JA; Olson EN. 2007. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 21(14):1790-802. [PubMed: 17639084] [MGI Ref ID J:123173]
Montgomery RL; Potthoff MJ; Haberland M; Qi X; Matsuzaki S; Humphries KM; Richardson JA; Bassel-Duby R; Olson EN. 2008. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest 118(11):3588-97. [PubMed: 18830415] [MGI Ref ID J:144604]
Morley GE; Danik SB; Bernstein S; Sun Y; Rosner G; Gutstein DE; Fishman GI. 2005. Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation. Proc Natl Acad Sci U S A 102(11):4126-9. [PubMed: 15753312] [MGI Ref ID J:97187]
Moslehi J; Minamishima YA; Shi J; Neuberg D; Charytan DM; Padera RF; Signoretti S; Liao R; Kaelin WG Jr. 2010. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 122(10):1004-16. [PubMed: 20733101] [MGI Ref ID J:179490]
Mysliwiec MR; Bresnick EH; Lee Y. 2011. Endothelial jarid2/jumonji is required for normal cardiac development and proper notch1 expression. J Biol Chem 286(19):17193-204. [PubMed: 21402699] [MGI Ref ID J:172692]
Mysliwiec MR; Chen J; Powers PA; Bartley CR; Schneider MD; Lee Y. 2006. Generation of a conditional null allele of jumonji. Genesis 44(9):407-11. [PubMed: 16900512] [MGI Ref ID J:114450]
Nakai A; Yamaguchi O; Takeda T; Higuchi Y; Hikoso S; Taniike M; Omiya S; Mizote I; Matsumura Y; Asahi M; Nishida K; Hori M; Mizushima N; Otsu K. 2007. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13(5):619-24. [PubMed: 17450150] [MGI Ref ID J:121778]
Nakaoka Y; Nishida K; Narimatsu M; Kamiya A; Minami T; Sawa H; Okawa K; Fujio Y; Koyama T; Maeda M; Sone M; Yamasaki S; Arai Y; Koh GY; Kodama T; Hirota H; Otsu K; Hirano T; Mochizuki N. 2007. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J Clin Invest 117(7):1771-81. [PubMed: 17571162] [MGI Ref ID J:124033]
Neary MT; Mohun TJ; Breckenridge RA. 2012. A mouse model to study the link between hypoxia, long QT interval and sudden infant death syndrome. Dis Model Mech :. [PubMed: 22977222] [MGI Ref ID J:193425]
Ngoh GA; Papanicolaou KN; Walsh K. 2012. Loss of mitofusin 2 promotes endoplasmic reticulum stress. J Biol Chem 287(24):20321-32. [PubMed: 22511781] [MGI Ref ID J:186517]
Nishida K; Yamaguchi O; Hirotani S; Hikoso S; Higuchi Y; Watanabe T; Takeda T; Osuka S; Morita T; Kondoh G; Uno Y; Kashiwase K; Taniike M; Nakai A; Matsumura Y; Miyazaki J; Sudo T; Hongo K; Kusakari Y; Kurihara S; Chien KR; Takeda J; Hori M; Otsu K. 2004. p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol 24(24):10611-20. [PubMed: 15572667] [MGI Ref ID J:95116]
Niu Z; Yu W; Zhang SX; Barron M; Belaguli NS; Schneider MD; Parmacek M; Nordheim A; Schwartz RJ. 2005. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem 280(37):32531-8. [PubMed: 15929941] [MGI Ref ID J:101311]
Oka S; Alcendor R; Zhai P; Park JY; Shao D; Cho J; Yamamoto T; Tian B; Sadoshima J. 2011. PPARalpha-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway. Cell Metab 14(5):598-611. [PubMed: 22055503] [MGI Ref ID J:179686]
Oka T; Hikoso S; Yamaguchi O; Taneike M; Takeda T; Tamai T; Oyabu J; Murakawa T; Nakayama H; Nishida K; Akira S; Yamamoto A; Komuro I; Otsu K. 2012. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485(7397):251-5. [PubMed: 22535248] [MGI Ref ID J:183992]
Olaopa M; Zhou HM; Snider P; Wang J; Schwartz RJ; Moon AM; Conway SJ. 2011. Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation. Dev Biol 356(2):308-22. [PubMed: 21600894] [MGI Ref ID J:175400]
Papanicolaou KN; Khairallah RJ; Ngoh GA; Chikando A; Luptak I; O'Shea KM; Riley DD; Lugus JJ; Colucci WS; Lederer WJ; Stanley WC; Walsh K. 2011. Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol 31(6):1309-28. [PubMed: 21245373] [MGI Ref ID J:170619]
Papanicolaou KN; Ngoh GA; Dabkowski ER; O'Connell KA; Ribeiro RF Jr; Stanley WC; Walsh K. 2012. Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death. Am J Physiol Heart Circ Physiol 302(1):H167-79. [PubMed: 22037195] [MGI Ref ID J:181573]
Patten IS; Rana S; Shahul S; Rowe GC; Jang C; Liu L; Hacker MR; Rhee JS; Mitchell J; Mahmood F; Hess P; Farrell C; Koulisis N; Khankin EV; Burke SD; Tudorache I; Bauersachs J; del Monte F; Hilfiker-Kleiner D; Karumanchi SA; Arany Z. 2012. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485(7398):333-8. [PubMed: 22596155] [MGI Ref ID J:184748]
Qiu Z; Cang Y; Goff SP. 2010. c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci U S A 107(3):1136-41. [PubMed: 20080568] [MGI Ref ID J:156743]
Qu J; Zhou J; Ping Yi X; Dong B; Zheng H; Miller LM; Wang X; Schneider MD; Li F. 2007. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction. J Mol Cell Cardiol 43(3):319-26. [PubMed: 17673255] [MGI Ref ID J:125231]
Raake PW; Vinge LE; Gao E; Boucher M; Rengo G; Chen X; DeGeorge BR Jr; Matkovich S; Houser SR; Most P; Eckhart AD; Dorn GW 2nd; Koch WJ. 2008. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res 103(4):413-22. [PubMed: 18635825] [MGI Ref ID J:152649]
Razani B; Zhang H; Schulze PC; Schilling JD; Verbsky J; Lodhi IJ; Topkara VK; Feng C; Coleman T; Kovacs A; Kelly DP; Saffitz JE; Dorn GW 2nd; Nichols CG; Semenkovich CF. 2011. Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem 286(35):30949-61. [PubMed: 21757749] [MGI Ref ID J:176617]
Sano M; Izumi Y; Helenius K; Asakura M; Rossi DJ; Xie M; Taffet G; Hu L; Pautler RG; Wilson CR; Boudina S; Abel ED; Taegtmeyer H; Scaglia F; Graham BH; Kralli A; Shimizu N; Tanaka H; Makela TP; Schneider MD. 2007. Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab 5(2):129-42. [PubMed: 17276355] [MGI Ref ID J:129766]
Schaeffer PJ; Desantiago J; Yang J; Flagg TP; Kovacs A; Weinheimer CJ; Courtois M; Leone TC; Nichols CG; Bers DM; Kelly DP. 2009. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol 297(4):H1263-73. [PubMed: 19700627] [MGI Ref ID J:154326]
Schaeffer PJ; Wende AR; Magee CJ; Neilson JR; Leone TC; Chen F; Kelly DP. 2004. Calcineurin and calcium/calmodulin-dependent protein kinase activate distinct metabolic gene regulatory programs in cardiac muscle. J Biol Chem 279(38):39593-603. [PubMed: 15262994] [MGI Ref ID J:93357]
Schulte JS; Seidl MD; Nunes F; Freese C; Schneider M; Schmitz W; Muller FU. 2012. CREB critically regulates action potential shape and duration in the adult mouse ventricle. Am J Physiol Heart Circ Physiol 302(10):H1998-2007. [PubMed: 22427515] [MGI Ref ID J:186739]
Sdek P; Zhao P; Wang Y; Huang CJ; Ko CY; Butler PC; Weiss JN; Maclellan WR. 2011. Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes. J Cell Biol 194(3):407-23. [PubMed: 21825075] [MGI Ref ID J:176968]
Shimano M; Ouchi N; Nakamura K; Oshima Y; Higuchi A; Pimentel DR; Panse KD; Lara-Pezzi E; Lee SJ; Sam F; Walsh K. 2011. Cardiac Myocyte-specific Ablation of Follistatin-like 3 Attenuates Stress-induced Myocardial Hypertrophy. J Biol Chem 286(11):9840-8. [PubMed: 21245136] [MGI Ref ID J:170624]
Shimano M; Ouchi N; Nakamura K; van Wijk B; Ohashi K; Asaumi Y; Higuchi A; Pimentel DR; Sam F; Murohara T; van den Hoff MJ; Walsh K. 2011. Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. Proc Natl Acad Sci U S A 108(43):E899-906. [PubMed: 21987816] [MGI Ref ID J:177416]
Shohet RV; Kisanuki YY; Zhao XS; Siddiquee Z; Franco F; Yanagisawa M. 2004. Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A 101(7):2088-93. [PubMed: 14764893] [MGI Ref ID J:90390]
Singh KK; Shukla PC; Quan A; Desjardins JF; Lovren F; Pan Y; Garg V; Gosal S; Garg A; Szmitko PE; Schneider MD; Parker TG; Stanford WL; Leong-Poi H; Teoh H; Al-Omran M; Verma S. 2012. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem 287(9):6604-14. [PubMed: 22157755] [MGI Ref ID J:182460]
Singh R; Hoogaars WM; Barnett P; Grieskamp T; Rana MS; Buermans H; Farin HF; Petry M; Heallen T; Martin JF; Moorman AF; 't Hoen PA; Kispert A; Christoffels VM. 2011. Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci :. [PubMed: 22130515] [MGI Ref ID J:181526]
Skryabin BV; Holtwick R; Fabritz L; Kruse MN; Veltrup I; Stypmann J; Kirchhof P; Sabrane K; Bubikat A; Vobeta M; Kuhn M. 2004. Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by alphaMHC-Cre-mediated recombination. Genesis 39(4):288-98. [PubMed: 15287002] [MGI Ref ID J:91993]
Su H; Li F; Ranek MJ; Wei N; Wang X. 2011. COP9 signalosome regulates autophagosome maturation. Circulation 124(19):2117-28. [PubMed: 21986281] [MGI Ref ID J:189459]
Su H; Li J; Menon S; Liu J; Kumarapeli AR; Wei N; Wang X. 2011. Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice. Circ Res 108(1):40-50. [PubMed: 21051661] [MGI Ref ID J:183513]
Takeda N; Manabe I; Uchino Y; Eguchi K; Matsumoto S; Nishimura S; Shindo T; Sano M; Otsu K; Snider P; Conway SJ; Nagai R. 2010. Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 120(1):254-65. [PubMed: 20038803] [MGI Ref ID J:156696]
Taneike M; Mizote I; Morita T; Watanabe T; Hikoso S; Yamaguchi O; Takeda T; Oka T; Tamai T; Oyabu J; Murakawa T; Nakayama H; Nishida K; Takeda J; Mochizuki N; Komuro I; Otsu K. 2011. Calpain protects the heart from hemodynamic stress. J Biol Chem 286(37):32170-7. [PubMed: 21795695] [MGI Ref ID J:176736]
Taniike M; Yamaguchi O; Tsujimoto I; Hikoso S; Takeda T; Nakai A; Omiya S; Mizote I; Nakano Y; Higuchi Y; Matsumura Y; Nishida K; Ichijo H; Hori M; Otsu K. 2008. Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy. Circulation 117(4):545-52. [PubMed: 18195174] [MGI Ref ID J:145085]
Tanowitz HB; Huang H; Jelicks LA; Chandra M; Loredo ML; Weiss LM; Factor SM; Shtutin V; Mukherjee S; Kitsis RN; Christ GJ; Wittner M; Shirani J; Kisanuki YY; Yanagisawa M. 2005. Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect Immun 73(4):2496-503. [PubMed: 15784596] [MGI Ref ID J:97201]
Tessari A; Pietrobon M; Notte A; Cifelli G; Gage PJ; Schneider MD; Lembo G; Campione M. 2008. Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res 102(7):813-22. [PubMed: 18292603] [MGI Ref ID J:147648]
Vintersten K; Monetti C; Gertsenstein M; Zhang P; Laszlo L; Biechele S; Nagy A. 2004. Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals. Genesis 40(4):241-6. [PubMed: 15593332] [MGI Ref ID J:109837]
Vong LH; Ragusa MJ; Schwarz JJ. 2005. Generation of conditional Mef2cloxP/loxP mice for temporal- and tissue-specific analyses. Genesis 43(1):43-8. [PubMed: 16106363] [MGI Ref ID J:100949]
Wang H; Knaub LA; Jensen DR; Young Jung D; Hong EG; Ko HJ; Coates AM; Goldberg IJ; de la Houssaye BA; Janssen RC; McCurdy CE; Rahman SM; Soo Choi C; Shulman GI; Kim JK; Friedman JE; Eckel RH. 2009. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes 58(1):116-24. [PubMed: 18952837] [MGI Ref ID J:146987]
Wang J; Sridurongrit S; Dudas M; Thomas P; Nagy A; Schneider MD; Epstein JA; Kaartinen V. 2005. Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heart. Dev Biol 286(1):299-310. [PubMed: 16140292] [MGI Ref ID J:103532]
Xie M; Zhang D; Dyck JR; Li Y; Zhang H; Morishima M; Mann DL; Taffet GE; Baldini A; Khoury DS; Schneider MD. 2006. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A 103(46):17378-83. [PubMed: 17085580] [MGI Ref ID J:117108]
Xiong S; Van Pelt CS; Elizondo-Fraire AC; Fernandez-Garcia B; Lozano G. 2007. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation 115(23):2925-30. [PubMed: 17533180] [MGI Ref ID J:137114]
Xu H; Morishima M; Wylie JN; Schwartz RJ; Bruneau BG; Lindsay EA; Baldini A. 2004. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 131(13):3217-27. [PubMed: 15175244] [MGI Ref ID J:91013]
Xu J; Ismat FA; Wang T; Lu MM; Antonucci N; Epstein JA. 2009. Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction. Circ Res 105(3):304-11. [PubMed: 19574548] [MGI Ref ID J:164937]
Yamaguchi O; Watanabe T; Nishida K; Kashiwase K; Higuchi Y; Takeda T; Hikoso S; Hirotani S; Asahi M; Taniike M; Nakai A; Tsujimoto I; Matsumura Y; Miyazaki J; Chien KR; Matsuzawa A; Sadamitsu C; Ichijo H; Baccarini M; Hori M; Otsu K. 2004. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 114(7):937-43. [PubMed: 15467832] [MGI Ref ID J:93418]
Yamashita H; Bharadwaj KG; Ikeda S; Park TS; Goldberg IJ. 2008. Cardiac metabolic compensation to hypertension requires lipoprotein lipase. Am J Physiol Endocrinol Metab 295(3):E705-13. [PubMed: 18647880] [MGI Ref ID J:139973]
Yang D; Zhang J; Chen C; Xie M; Sperling S; Fang F; Chen B; Li X; Zhang H. 2008. BMPR IA downstream genes related to VSD. Pediatr Res 63(6):602-6. [PubMed: 18543407] [MGI Ref ID J:137990]
Yao JA; Gutstein DE; Liu F; Fishman GI; Wit AL. 2003. Cell coupling between ventricular myocyte pairs from connexin43-deficient murine hearts. Circ Res 93(8):736-43. [PubMed: 14500334] [MGI Ref ID J:115657]
Zeisberg EM; Ma Q; Juraszek AL; Moses K; Schwartz RJ; Izumo S; Pu WT. 2005. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115(6):1522-1531. [PubMed: 15902305] [MGI Ref ID J:99203]
Zelarayan L; Renger A; Noack C; Zafiriou MP; Gehrke C; van der Nagel R; Dietz R; de Windt L; Bergmann MW. 2009. NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res 84(3):416-24. [PubMed: 19620128] [MGI Ref ID J:172480]
Zhao XS; Pan W; Bekeredjian R; Shohet RV. 2006. Endogenous endothelin-1 is required for cardiomyocyte survival in vivo. Circulation 114(8):830-7. [PubMed: 16908774] [MGI Ref ID J:123980]
Zhou B; Ma Q; Rajagopal S; Wu SM; Domian I; Rivera-Feliciano J; Jiang D; von Gise A; Ikeda S; Chien KR; Pu WT. 2008. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454(7200):109-13. [PubMed: 18568026] [MGI Ref ID J:137426]
Zhu Z; Burnett CM; Maksymov G; Stepniak E; Sierra A; Subbotina E; Anderson ME; Coetzee WA; Hodgson-Zingman DM; Zingman LV. 2011. Reduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia. Biochem Biophys Res Commun 415(4):637-41. [PubMed: 22079630] [MGI Ref ID J:179209]
Zingman LV; Zhu Z; Sierra A; Stepniak E; Burnett CM; Maksymov G; Anderson ME; Coetzee WA; Hodgson-Zingman DM. 2011. Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation. J Mol Cell Cardiol 51(1):72-81. [PubMed: 21439969] [MGI Ref ID J:173790]
de Lange FJ; Moorman AF; Anderson RH; Manner J; Soufan AT; de Gier-de Vries C; Schneider MD; Webb S; van den Hoff MJ; Christoffels VM. 2004. Lineage and morphogenetic analysis of the cardiac valves. Circ Res 95(6):645-54. [PubMed: 15297379] [MGI Ref ID J:155846]
van Oort RJ; van Rooij E; Bourajjaj M; Schimmel J; Jansen MA; van der Nagel R; Doevendans PA; Schneider MD; van Echteld CJ; De Windt LJ. 2006. MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure. Circulation 114(4):298-308. [PubMed: 16847152] [MGI Ref ID J:123084]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintained as a live colony, hemizygotes may be bred. Mating System Hemizygote x Noncarrier (Female x Male) 16-MAR-10 Diet Information LabDiet® 5K52/5K67
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Pricing, Supply Level & Notes, Controls
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Myh6-cre)2182Mds
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(Myh6-cre)2182Mds x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(Myh6-cre)2182Mds Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Myh6-cre)2182Mds
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(Myh6-cre)2182Mds x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(Myh6-cre)2182Mds Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.