Strain Name:

C(TSJ)-Rpl38Ts/GrsrJ

Stock Number:

011114

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names C(TSJ)-Ts/GrsrJ    (Changed: 07-MAR-11 )
BALB/cJ x TSJ/LeJ    (Changed: 04-MAR-10 )
Type Mutant Stock; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationN4pN1
Generation Definitions

Appearance
agouti brown, tail defects
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyr+ Ts/+

agouti brown, normal tail
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyr+ +/+

albino, tail defects
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc Ts/+

albino, normal tail
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/Tyrc +/+

Description
Homozygosity for the tail short mutation causes early embryonic lethality. Heterozygotes are smaller than normal and have variably shortened tails with flexures. Skeletal abnormalities are found with varying expressivity including vertebral fusions, bilateral asymmetry of the length of the humerus and tibia, triphalangy of digit 1 of the forefoot, an extra pair of ribs, and craniofacial defects. Embryonic anemia and reduced fertility are also found.

Development
The Ts mutation arose spontaneously in 1946 at the National Cancer Institute in BALB/c (strain C of the Bagg albino strain) when that inbred was at generation F63. W.C. Morgan gave this mutant subline to George Snell at The Jackson Laboratory in 1950 and Snell outcrossed it to C57BL/6, C57BR/a, and BALB/cSn before inbreeding began on this new background and the line was transferred to Skippy Lane. The TSJ/Le inbred reached generation F41 in 1979 and F130 in 2007. When this inbred reached generation F132 it was backcrossed repeatedly to BALB/cJ and in 2010 sperm was cryopreserved from males heterozygous for Ts and Tyrc and homozygous for Tyrp1b then at generation N4. Cryorecovery using BALB/cJ females for in vitro fertilization has proven successful.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Otitis Media, Susceptibility to
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Rpl38Ts/Rpl38+

        involves: BALB/c
  • embryogenesis phenotype
  • abnormal notochord morphology
    • histology at embyronic day 9.5 shows many sections of the perinotochordal sheath are normal while nearby sections have varying degrees of disintegration of the notochordal sheath   (MGI Ref ID J:803)
    • lateral defelection of the notocord also confirmed at embryonic day 9.5   (MGI Ref ID J:803)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Rpl38Ts/Rpl38+

        BALB/c-Rpl38Ts
  • mortality/aging
  • partial perinatal lethality
    • normal segregation at embryonic day 17 from matings of heterozygote x wildtype, but less than Mendelian predicted ratio at birth   (MGI Ref ID J:15012)
  • craniofacial phenotype
  • abnormal nasal cavity morphology
    • nasals are short, malformed and usually fused to the frontals, and the nasal processes are greadly reduced and sometimes bent sideways   (MGI Ref ID J:15012)
  • decreased cranium height
    • in the short-snouted heterozygotes   (MGI Ref ID J:15012)
  • increased cranium width
    • greater width of the frontal bones   (MGI Ref ID J:15012)
  • short snout
    • in the most severely affected   (MGI Ref ID J:15012)
  • growth/size/body phenotype
  • decreased body size
    • evident as early as embryonic day 9   (MGI Ref ID J:15012)
    • decreased body length
      • slightly shortened body length of 85-95 mm versus 101 mm wildtype   (MGI Ref ID J:13063)
    • decreased body weight
      • mutants weigh considerably less at birth and this persists throughout life   (MGI Ref ID J:15012)
  • embryonic growth retardation
    • by embryonic day 14 there is a developmental delay of approximately 1 day, but by embyronic day 17 this delay is decreased   (MGI Ref ID J:15012)
  • limbs/digits/tail phenotype
  • abnormal autopod morphology   (MGI Ref ID J:13063)
    • in a few cases the front paw is shortened and turned inward resembling a flipper   (MGI Ref ID J:15012)
  • abnormal humerus morphology   (MGI Ref ID J:15012)
    • short humerus   (MGI Ref ID J:15012)
  • caudal vertebral fusion   (MGI Ref ID J:13063)
    • common in heterozygotes and take place at all angles   (MGI Ref ID J:15012)
  • curly tail   (MGI Ref ID J:15012)
  • decreased caudal vertebrae number   (MGI Ref ID J:13063)
    • there are fewer caudal vertebrae than normal and these are smaller than normal   (MGI Ref ID J:15012)
  • kinked tail
    • the tail is usually kinked and sometimes curled   (MGI Ref ID J:15012)
    • varying number of flexures due to irregular fusion of the vertebrae   (MGI Ref ID J:13063)
  • short femur   (MGI Ref ID J:15012)
  • short radius   (MGI Ref ID J:15012)
  • short tail
    • varied penetrance, tail ranges from a small stump to approximately seven-eighths normal length   (MGI Ref ID J:15012)
    • variable tail length ranging from 8-45 mm versus 103 mm for wildtype, but no tailless mice found   (MGI Ref ID J:13063)
  • short tibia   (MGI Ref ID J:15012)
  • small caudal vertebrae   (MGI Ref ID J:15012)
  • embryogenesis phenotype
  • abnormal neural tube morphology/development
    • although nornmal at embryonic day 9, at embryonic day 10 to 11 the neural tube and notochord change shape, thickness and position several times along the length of the tail and the last somite is closer than normal to the tail tip. The neural tube is not affected in the trunk region until embryonic day 12 to 13 when it is thinner and when there are significant irregularities of shape and position of the notochord and neural tube.   (MGI Ref ID J:15012)
    • abnormal neuromere morphology   (MGI Ref ID J:15012)
    • wavy neural tube   (MGI Ref ID J:15012)
  • abnormal notochord morphology
    • although nornmal at embryonic day 9, at embryonic day 10 to 11 the neural tube and notochord change shape, thickness and position several times along the length of the tail and the last somite is closer than normal to the tail tip. The neural tube is not affected in the trunk region until embryonic day 12 to 13 when it is thinner and when there are significant irregularities of shape and position of the notochord and neural tube.   (MGI Ref ID J:15012)
  • abnormal placenta vasculature   (MGI Ref ID J:15012)
  • abnormal vitelline vasculature morphology
    • blood vessels are paler, thinner, fewer in the placenta and yolk sac   (MGI Ref ID J:15012)
  • embryonic growth retardation
    • by embryonic day 14 there is a developmental delay of approximately 1 day, but by embyronic day 17 this delay is decreased   (MGI Ref ID J:15012)
  • skeleton phenotype
  • abnormal humerus morphology   (MGI Ref ID J:15012)
    • short humerus   (MGI Ref ID J:15012)
  • abnormal metacarpal bone morphology
    • feet can have fusions, absence of bones, and extra phalanges   (MGI Ref ID J:15012)
  • abnormal metatarsal bone morphology   (MGI Ref ID J:15012)
  • abnormal sacral vertebrae morphology
    • 4th sacral vertebrae often often has laterally directed transverse processes and well defined alae sacrales whereas normally the 4th sacral vertebrae has anteriorly directed transverse processes without well defined alae sacrales   (MGI Ref ID J:15012)
  • abnormal sternebra morphology
    • in some heterozygotes the fifth sternebra appears to have been formed from two separate elements   (MGI Ref ID J:15012)
    • increased sternebra number
      • an extra sternebra is found in some heterozygotes   (MGI Ref ID J:15012)
    • sternebra fusion
      • sternebrae fusions are found in some heterozygotes   (MGI Ref ID J:15012)
  • abnormal vertebrae development
    • gaps in the vertebral arch or centrum   (MGI Ref ID J:15012)
  • decreased caudal vertebrae number   (MGI Ref ID J:13063)
    • there are fewer caudal vertebrae than normal and these are smaller than normal   (MGI Ref ID J:15012)
  • decreased cranium height
    • in the short-snouted heterozygotes   (MGI Ref ID J:15012)
  • decreased length of long bones
    • the length of the left humerus is shorter and the length of the right tibia is shorter than normal resulting in lopsided leg length, and the radius and femur are also shortened in some instances   (MGI Ref ID J:15012)
    • short femur   (MGI Ref ID J:15012)
    • short humerus   (MGI Ref ID J:15012)
    • short radius   (MGI Ref ID J:15012)
    • short tibia   (MGI Ref ID J:15012)
  • increased cranium width
    • greater width of the frontal bones   (MGI Ref ID J:15012)
  • increased rib number
    • an additional pair of ribs is found along with the increase in thoracic vertebrae   (MGI Ref ID J:15012)
  • increased thoracic vertebrae number
    • heterozygotes usually have 14 instead of the usual 13 thoracic vertebrae   (MGI Ref ID J:15012)
  • rib fusion   (MGI Ref ID J:15012)
  • small caudal vertebrae   (MGI Ref ID J:15012)
  • vertebral fusion
    • the vertebrae most susceptible to fusion are cervical 3 and 4 and thoracic 9, 10, and 11   (MGI Ref ID J:15012)
    • caudal vertebral fusion   (MGI Ref ID J:13063)
      • common in heterozygotes and take place at all angles   (MGI Ref ID J:15012)
  • hematopoietic system phenotype
  • anemia
    • anemia is reported from embryonic day 9, pronounced at embryonic day 14, but newborns are not anemic   (MGI Ref ID J:15012)
  • cardiovascular system phenotype
  • abnormal heart development
    • at embryonic day 12 to 13 the atrium is abnormally large, the verntricle abnormally small, the walls of the ventricle are thin and the trabeculae poorly developed, but the heart is normal at embryonic day 17   (MGI Ref ID J:15012)
  • abnormal placenta vasculature   (MGI Ref ID J:15012)
  • abnormal vitelline vasculature morphology
    • blood vessels are paler, thinner, fewer in the placenta and yolk sac   (MGI Ref ID J:15012)
  • respiratory system phenotype
  • abnormal nasal cavity morphology
    • nasals are short, malformed and usually fused to the frontals, and the nasal processes are greadly reduced and sometimes bent sideways   (MGI Ref ID J:15012)
  • nervous system phenotype
  • abnormal neural tube morphology/development
    • although nornmal at embryonic day 9, at embryonic day 10 to 11 the neural tube and notochord change shape, thickness and position several times along the length of the tail and the last somite is closer than normal to the tail tip. The neural tube is not affected in the trunk region until embryonic day 12 to 13 when it is thinner and when there are significant irregularities of shape and position of the notochord and neural tube.   (MGI Ref ID J:15012)
    • abnormal neuromere morphology   (MGI Ref ID J:15012)
    • wavy neural tube   (MGI Ref ID J:15012)
  • abnormal olfactory bulb morphology
    • the brain is shortened longitudinally especially the olfactory region   (MGI Ref ID J:15012)

Rpl38Ts/Rpl38+

        (TSJ/Le x C57BL/6JJcl)F1
  • limbs/digits/tail phenotype
  • short tail
    • the outcross to a C57BL/6J background resulted in a shorter average tail length than on the pure TSJ/Le background   (MGI Ref ID J:47940)

Rpl38Ts/Rpl38+

        (TSJ/Le x A/JSlc)F1
  • mortality/aging
  • complete postnatal lethality
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal   (MGI Ref ID J:47940)

Rpl38Ts/Rpl38+

        (TSJ/Le x CBA/J)F1
  • mortality/aging
  • complete postnatal lethality
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal   (MGI Ref ID J:47940)

Rpl38Ts/Rpl38+

        (TSJ/Le x C3.SW-H2b/SnJ)F1
  • mortality/aging
  • complete postnatal lethality
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal   (MGI Ref ID J:47940)

Rpl38Ts/Rpl38+

        (TSJ/Le x AKR/J)F1
  • mortality/aging
  • complete postnatal lethality
    • the short tail phenotype is entirely missing from litters at wean age and litters are smaller than normal   (MGI Ref ID J:47940)

Rpl38Ts/Rpl38+

        (BALB/c x C3H)F1
  • mortality/aging
  • partial perinatal lethality
    • half of the tailless mutants are born dead and some of these are almost devoid of blood and sometimes lack vescera   (MGI Ref ID J:13063)
  • limbs/digits/tail phenotype
  • abnormal digit morphology
    • frequency is approximately 80% on the left forefoot, 10-15% on the right forefoot, and less than 10% on the hindfeet   (MGI Ref ID J:13063)
    • oligodactyly   (MGI Ref ID J:13063)
    • polydactyly
      • more common than oligodactyly and nearly always present in tailless heterozygotes   (MGI Ref ID J:13063)
  • abnormal forelimb morphology
    • on occassion foreleg shortened and turned mediad such that it resembles a flipper   (MGI Ref ID J:13063)
  • absent caudal vertebrae   (MGI Ref ID J:13063)
  • absent tail
    • none of the (BALB/c x C3H)F1 mice have tails, far more severe than the short tail phenotype of the BALB/c background   (MGI Ref ID J:13063)
  • growth/size/body phenotype
  • decreased body length
    • shorter than heterozygotes on the BALB/c background and only approximnately two-thirds the body length of wildtype F1 controls   (MGI Ref ID J:13063)
  • skeleton phenotype
  • abnormal nasal bone morphology
    • non-fusion of the nasals at the anterior end of the skull is often found   (MGI Ref ID J:13063)
  • absent caudal vertebrae   (MGI Ref ID J:13063)
  • decreased cranium height
    • in all of the tailless subset   (MGI Ref ID J:13063)
  • increased cranium width
    • in all of the tailless subset   (MGI Ref ID J:13063)
  • reproductive system phenotype
  • reduced fertility
    • none of the 4 surviving tailless heterozygotes bred; the one surviving female tailless heterozygote birthed one litter of 3 pups then died   (MGI Ref ID J:13063)
  • hematopoietic system phenotype
  • anemia   (MGI Ref ID J:13063)
  • nervous system phenotype
  • incomplete rostral neuropore closure
    • some of the tailless subset are found to have spina bifida and even a dorsal cephalic opening due to failure of cranial fusion over the brain   (MGI Ref ID J:13063)
  • spina bifida
    • in some of the tailless subset   (MGI Ref ID J:13063)
  • pigmentation phenotype
  • belly spot   (MGI Ref ID J:13063)
  • irregular coat pigmentation
    • tailless subset of mutants have white hairs on the front legs that looks like white stockings   (MGI Ref ID J:13063)
  • craniofacial phenotype
  • abnormal nasal bone morphology
    • non-fusion of the nasals at the anterior end of the skull is often found   (MGI Ref ID J:13063)
  • decreased cranium height
    • in all of the tailless subset   (MGI Ref ID J:13063)
  • increased cranium width
    • in all of the tailless subset   (MGI Ref ID J:13063)
  • embryogenesis phenotype
  • incomplete rostral neuropore closure
    • some of the tailless subset are found to have spina bifida and even a dorsal cephalic opening due to failure of cranial fusion over the brain   (MGI Ref ID J:13063)
  • spina bifida
    • in some of the tailless subset   (MGI Ref ID J:13063)
  • integument phenotype
  • belly spot   (MGI Ref ID J:13063)
  • irregular coat pigmentation
    • tailless subset of mutants have white hairs on the front legs that looks like white stockings   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x A)F1
  • mortality/aging
  • complete embryonic lethality
    • no mutant offspring were found in this cross and litters average 3.53 pups instead of 7.74, so tail short is believed to be a complete heterozygous lethal when crossed to the A inbred background   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x DBA)F1
  • limbs/digits/tail phenotype
  • absent tail
    • no short tailed mice are generated, only a small number of tailless mice indicating a more severe expressivity with the DBA background   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x L)F1
  • limbs/digits/tail phenotype
  • short tail
    • the phenotype is similar to that found in pure BALB/c   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x Y)F1
  • limbs/digits/tail phenotype
  • short tail
    • the phenotype is similar to that found on the pure BALB/c background regardless of the presence or absence of lethal yellow   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x I)F1
  • limbs/digits/tail phenotype
  • short tail
    • the phenotype is similar to that found in pure BALB/c   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x C57BR)F1
  • limbs/digits/tail phenotype
  • short tail
    • this hybrid background yields a slightly milder phenotype such that most mutants have a phenotype similar to that on the pure BALB/c background, but a few have tails longer than one-half normal length   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        (BALB/c x C57BL)F1
  • limbs/digits/tail phenotype
  • short tail
    • this hybrid background yields a very mild phenotype such that more than half of the mutants are have a normal body length at birth and they have a less kinked, longer tail than the mutants do on the pure BALB/c background   (MGI Ref ID J:13063)

Rpl38Ts/Rpl38+

        TSJ/Le
  • limbs/digits/tail phenotype
  • short tail   (MGI Ref ID J:168509)
    • as early as embryonic day 11   (MGI Ref ID J:6184)
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype
    • the changes in the three hemoglobins expressed during fetal development from embryonic day 10 to 15 are normal   (MGI Ref ID J:6184)
    • abnormal embryonic erythropoiesis
      • embryonic day 12-14 primitive nucleated erythrocytes have less hemoglobin content per cell than normal   (MGI Ref ID J:6184)
      • embryonic day 11-13 primitive nucleated erythrocytes have increased mitotic indices   (MGI Ref ID J:6184)
      • embryonic day 13 only 7% of the circulating cells are small non-nucleated erythrocytes compared with one third of the circulating cells in wildtype controls   (MGI Ref ID J:6184)
      • delayed fetal hepatic erythropoiesis wherein embyronic day 12 mutants have primarily immature erythroid precursors and wildtype controls have many immature and mature erythroblasts   (MGI Ref ID J:6184)
  • hearing/vestibular/ear phenotype
  • abnormal hearing physiology   (MGI Ref ID J:168509)
    • abnormal distortion product otoacoustic emission
      • decrease in emissions at the tone 1 = 75 db stimulus level over a wide range of frequencies at 3 weeks of age   (MGI Ref ID J:168509)
    • conductive hearing loss   (MGI Ref ID J:168509)
    • increased or absent threshold for auditory brainstem response
      • increased thresholds to click and 8 kHz stimuli at 4 weeks of age   (MGI Ref ID J:168509)
      • at 8 weeks of age thresholds are increased at 8, 16, and 32 kHz, the average increase is 28db   (MGI Ref ID J:168509)
  • abnormal middle ear morphology
    • excess deposition of fine crystals frequently filling the entire cavity   (MGI Ref ID J:168509)
    • in some cases crystals surround and even cover the stapes   (MGI Ref ID J:168509)
    • abnormal auditory tube
      • enlarged at 3, 4, 12 and 36 weeks of age   (MGI Ref ID J:168509)
    • abnormal oval window morphology
      • at 3 weeks of age large aggregates of fine crystals are often seen within the round window and at the oval window   (MGI Ref ID J:168509)
    • abnormal round window morphology
      • at 3 weeks of age large aggregates of fine crystals are often seen within the round window and at the oval window   (MGI Ref ID J:168509)
      • at 3 weeks of age locally restricted neo-ossification is seen on the round window ridge   (MGI Ref ID J:168509)
      • at 11 weeks of age there is a 1.5 fold increase in the volume of ectopic endochondral bone on the round window ridge   (MGI Ref ID J:168509)
  • increased susceptibility to otitis media
    • chronic inflammation with effusion   (MGI Ref ID J:168509)
    • at 2 weeks of age the periosteal layer appears dilated, swollen, and delaminated from the underlying bone   (MGI Ref ID J:168509)
    • inflammation persists at 36 and 56 weeks of age   (MGI Ref ID J:168509)
  • craniofacial phenotype
  • short snout   (MGI Ref ID J:168509)
  • growth/size/body phenotype
  • decreased body weight
    • at 8 weeks of age   (MGI Ref ID J:168509)
  • embryonic growth retardation
    • at embryonic day 11 mutants and wildtype can not be readily distinguished by growth retardation, but at embryonic day 12 mutants are clearly smaller and an approximately 1 day delay in development persists and is evident in reduced fetal weight and placental weight   (MGI Ref ID J:6184)
    • although the total hemoglobin content is lower in age matched mutant and wildtype embryos the ratio of hemoglobin content to embryo weight is normal indicating that the diminished hemoglobin level is part of the embryonic growth retardation   (MGI Ref ID J:6184)
  • omphalocele
    • in a small number of embryos   (MGI Ref ID J:6184)
  • nervous system phenotype
  • anencephaly
    • in a small number of embryos   (MGI Ref ID J:6184)
  • homeostasis/metabolism phenotype
  • increased circulating phosphate level
    • increase in organic phosphate levels   (MGI Ref ID J:168509)
  • embryogenesis phenotype
  • abnormal embryonic erythropoiesis
    • embryonic day 12-14 primitive nucleated erythrocytes have less hemoglobin content per cell than normal   (MGI Ref ID J:6184)
    • embryonic day 11-13 primitive nucleated erythrocytes have increased mitotic indices   (MGI Ref ID J:6184)
    • embryonic day 13 only 7% of the circulating cells are small non-nucleated erythrocytes compared with one third of the circulating cells in wildtype controls   (MGI Ref ID J:6184)
    • delayed fetal hepatic erythropoiesis wherein embyronic day 12 mutants have primarily immature erythroid precursors and wildtype controls have many immature and mature erythroblasts   (MGI Ref ID J:6184)
  • embryonic growth retardation
    • at embryonic day 11 mutants and wildtype can not be readily distinguished by growth retardation, but at embryonic day 12 mutants are clearly smaller and an approximately 1 day delay in development persists and is evident in reduced fetal weight and placental weight   (MGI Ref ID J:6184)
    • although the total hemoglobin content is lower in age matched mutant and wildtype embryos the ratio of hemoglobin content to embryo weight is normal indicating that the diminished hemoglobin level is part of the embryonic growth retardation   (MGI Ref ID J:6184)
  • immune system phenotype
  • increased susceptibility to otitis media
    • chronic inflammation with effusion   (MGI Ref ID J:168509)
    • at 2 weeks of age the periosteal layer appears dilated, swollen, and delaminated from the underlying bone   (MGI Ref ID J:168509)
    • inflammation persists at 36 and 56 weeks of age   (MGI Ref ID J:168509)

Rpl38Ts/Rpl38Ts

        BALB/c-Rpl38Ts
  • mortality/aging
  • complete embryonic lethality
    • all are detectable as unhealthy morula at embryonic day 3.5 and are dead by E5.5   (MGI Ref ID J:13063)
    • in vitro culturing does not rescue embryos   (MGI Ref ID J:13063)
  • partial embryonic lethality at implantation
    • at embryonic day 4.5 of heterozygous intercrosses there are fewer than the Mendelian expected 25% abnormal, presumed homozygous, embryos and the litter size is reduced suggesting the loss of some homozygotes between embryonic days 3.5 and 4.5   (MGI Ref ID J:6315)
    • the number of implantations at 7 and 8 days of pregnancy in heterozygous intercrosses is a quarter less than normal indicating that homozygotes die before implantation or soon afterwards   (MGI Ref ID J:15012)
  • cellular phenotype
  • abnormal nucleolus morphology
    • in embryonic day 3.5 presumed homozygous embryos nucleoli appear very ragged in outline and irregularly distribted in th nucleoplasm   (MGI Ref ID J:6315)
  • embryogenesis phenotype
  • abnormal preimplantation embryo development
    • retarded cell division begins after the third cleavage such that there are only half the normal number of cells on embryonic day 3.5 and 20% the normal number on embryonic day 4.5   (MGI Ref ID J:6315)
    • abnormal blastocyst morphology   (MGI Ref ID J:6315)
      • abnormal blastocoele morphology   (MGI Ref ID J:6315)
        • failure to form blastocele
          • at embryonic day 3.5 presumed homozygotes have not formed a blastocoele   (MGI Ref ID J:6315)
  • decreased embryo size
    • due to reduced number of embryonic cells   (MGI Ref ID J:6315)
  • embryonic growth arrest
    • at embryonic day 3.5 there are approximately 13.7 cells per embryo instead of the normal 30.3, haematoxylin staining is much more pale, and the nucleoli often appear ragged in outline and irregularly ditributed throughout the nucleoplasm   (MGI Ref ID J:6315)
    • at embryonic day 4.5 presumed homozygotes are retarded in developmental stage and cell number such that there is no clear delineation into inner cell mass and trophoblast, and these presumed homozygotes do not show signs of invasiveness when littermates are undergoing uterine attachment   (MGI Ref ID J:6315)
    • at embryonic day 5.5 there are very few abnormal embryos compared with earlier timepoints and these are in various stages of degeneration   (MGI Ref ID J:6315)
    • embryonic culture beginning at approximately day 3.5 confirms the in vivo findings   (MGI Ref ID J:6315)
  • embryonic growth retardation   (MGI Ref ID J:6315)
  • growth/size/body phenotype
  • decreased embryo size
    • due to reduced number of embryonic cells   (MGI Ref ID J:6315)
  • embryonic growth retardation   (MGI Ref ID J:6315)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Rpl38Ts related

Developmental Biology Research
Craniofacial and Palate Defects
Embryonic Lethality (Homozygous)
Growth Defects
Internal/Organ Defects
      heart
      vasculature
Skeletal Defects
      Oligodactyly

Hematological Research
Anemia, Iron Deficiency and Transport Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Rpl38Ts
Allele Name tail-short
Allele Type Spontaneous
Common Name(s) T-s;
Strain of OriginBALB/c
Gene Symbol and Name Rpl38, ribosomal protein L38
Chromosome 11
Gene Common Name(s) 0610025G13Rik; L38; RIKEN cDNA 0610025G13 gene; Rbt; Ts; Tss; rabo torcido; tail-short; tail-short Shionogi Institute;
Molecular Note An 18,189 kb region (from position 114,517 - 114,536 kb) was deleted and replaced with a 657 bp insertion showing high sequence similarity to the gag/pro-pol-dUTPase genes of the endogenous retrovirus MuERV-L. This deletion encompasses all of the exons of Rpl38. [MGI Ref ID J:168509]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Brotherton TW; Chui DH; McFarland EC; Russell ES. 1979. Fetal erythropoiesis and hemoglobin ontogeny in tail-short (Ts/+) mutant mice. Blood 54(3):673-83. [PubMed: 465735]  [MGI Ref ID J:6184]

Deol MS. 1961. Genetical studies on the skeleton of the mouse. XXVIII. Tail-short Proc R Soc Lond B Biol Sci 155:78-95.  [MGI Ref ID J:15012]

MORGAN WC. 1950. A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. J Hered 41(8):208-15. [PubMed: 14779008]  [MGI Ref ID J:13063]

Paterson HF. 1980. In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse. J Exp Zool 211(2):247-56. [PubMed: 7373273]  [MGI Ref ID J:6315]

Additional References

Rpl38Ts related

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Center EM; Marcus NM; Wilson DB. 1988. Abnormal development of the notochord and perinotochordal sheath in duplicitas posterior, patch and tail-short mice. Histol Histopathol 3(4):405-12. [PubMed: 2980249]  [MGI Ref ID J:803]

Hustert E; Scherer G; Olowson M; Guenet JL; Balling R. 1996. Rbt (Rabo torcido), a new mouse skeletal mutation involved in anteroposterior patterning of the axial skeleton, maps close to the Ts (tail-short) locus and distal to the Sox9 locus on chromosome 11. Mamm Genome 7(12):881-5. [PubMed: 8995757]  [MGI Ref ID J:37422]

Ishijima J; Yasui H; Morishima M; Shiroishi T. 1998. Dominant lethality of the mouse skeletal mutation tail-short (Ts) is determined by the Ts allele from mating partners. Genomics 49(3):341-50. [PubMed: 9615218]  [MGI Ref ID J:47940]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Kondrashov N; Pusic A; Stumpf CR; Shimizu K; Hsieh AC; Xue S; Ishijima J; Shiroishi T; Barna M. 2011. Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell 145(3):383-97. [PubMed: 21529712]  [MGI Ref ID J:173414]

Noben-Trauth K; Latoche JR. 2011. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. J Biol Chem 286(4):3079-93. [PubMed: 21062742]  [MGI Ref ID J:168509]

Russell ES; Bernstein SE. 1966. Blood and Blood Formation. In: Biology of the Laboratory Mouse. McGraw Hill, New York.  [MGI Ref ID J:24829]

Shiroishi T; Uchida K; Koopman P; Mita A; Wakana S; Moriwaki K. 1994. Annu Rep Natl Inst Genet Jpn 45:53-54.  [MGI Ref ID J:31828]

Sweet HO; Roderick TH; Davisson MT. 1979. [Linkage of Tail short (Ts).] Mouse News Lett 60:51.  [MGI Ref ID J:13797]

Uchida K; Koopman P; Mita A; Wakana S; Wright E; Kikkawa Y; Yonekawa H; Moriwaki K; Shiroishi T. 1996. Exclusion of Sox9 as a candidate for the mouse mutant tail-short. Mamm Genome 7(7):481-5. [PubMed: 8672134]  [MGI Ref ID J:34432]

Wagner T; Wirth J; Meyer J; Zabel B; Held M; Zimmer J; Pasantes J; Bricarelli FD; Keutel J; Hustert E; Wolf U; Tommerup N; Schempp W; Scherer G.. 1994. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell 79(6):1111-20. [PubMed: 8001137]  [MGI Ref ID J:22021]

Wright E; Hargrave MR; Christiansen J; Cooper L; Kun J; Evans T; Gangadharan U; Greenfield A; Koopman P. 1995. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nat Genet 9(1):15-20. [PubMed: 7704017]  [MGI Ref ID J:22300]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.5)