Strain Name:

STOCK Axltm1Grl/J

Stock Number:

011121

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
This targeted mutation of the AXL receptor tyrosine kinase (Axl) gene exhibits an overtly normal phenotype, however, in combination with mutations in other receptor tyrosine kinases, this strain may be useful in studies of autoimmunity, germ cell development and apoptosis.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6;129S1-Axltm1Grl/J    (Changed: 09-DEC-09 )
Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Generation?pN1
Generation Definitions
 
Donating Investigator Greg Lemke,   The Salk Institute

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When combined with the mutations Tyro3tm1Grl (Stock No. 007937) and Mertktm1Grl (Stock No. 011122), mice exhibit a lymphoproliferative disorder, autoimmunity, increased apoptosis in multiple tissues, blindness, abnormal spermatogenesis and reduced (in females) fertility or infertility (in males). This mutant mouse strain may be useful in studies of autoimmunity, germ cell development and apoptosis.

Development
A targeting vector was designed to introduce a neomycin resistance cassette into exon 9. The construct was electroporated into CB1-4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were intercrossed to generate homozygotes. Upon arrival at The Jackson Laboratory, mutant mice were bred to B6129SF2/J inbred mice (Stock No. 101045) to establish the colony.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Axl
005777   B6.129P2-Axltm1Dgen/J
View Strains carrying other alleles of Axl     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Axltm1Grl/Axltm1Grl

        involves: C57BL/6J
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • mutant Sertoli cells exhibit normal phagocytosis of apoptotic spermatogenic cells relative to wild-type controls, as determined by lipid droplet formation using Oil Red O staining   (MGI Ref ID J:133455)
    • viable and fertile   (MGI Ref ID J:54681)
  • cardiovascular system phenotype
  • increased vascular permeability
  • mortality/aging
  • *normal* mortality/aging
    • homozygotes are viable and fertile   (MGI Ref ID J:54681)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Apoptosis Research

Immunology, Inflammation and Autoimmunity Research
Autoimmunity

Reproductive Biology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Axltm1Grl
Allele Name targeted mutation 1, Greg Lemke
Allele Type Targeted (Null/Knockout)
Common Name(s) Axl-;
Mutation Made By Greg Lemke,   The Salk Institute
Strain of OriginC57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Gene Symbol and Name Axl, AXL receptor tyrosine kinase
Chromosome 7
Gene Common Name(s) AI323647; Ark; JTK11; Tyro7; UFO; Ufo; expressed sequence AI323647; ufo oncogene homolog;
Molecular Note A neomycin selection cassette replaced a segment of the gene containing exon 9. Western blot analysis on total brain lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. [MGI Ref ID J:54681]

Genotyping

Genotyping Information

Genotyping Protocols

Axltm1Grl, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Lu Q; Gore M; Zhang Q; Camenisch T; Boast S; Casagranda F; Lai C; Skinner MK; Klein R; Matsushima GK; Earp HS; Goff SP; Lemke G. 1999. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398(6729):723-8. [PubMed: 10227296]  [MGI Ref ID J:54681]

Additional References

Axltm1Grl related

Angelillo-Scherrer A; Burnier L; Flores N; Savi P; DeMol M; Schaeffer P; Herbert JM; Lemke G; Goff SP; Matsushima GK; Earp HS; Vesin C; Hoylaerts MF; Plaisance S; Collen D; Conway EM; Wehrle-Haller B; Carmeliet P. 2005. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115(2):237-46. [PubMed: 15650770]  [MGI Ref ID J:95952]

Angelillo-Scherrer A; Burnier L; Lambrechts D; Fish RJ; Tjwa M; Plaisance S; Sugamele R; DeMol M; Martinez-Soria E; Maxwell PH; Lemke G; Goff SP; Matsushima GK; Earp HS; Chanson M; Collen D; Izui S; Schapira M; Conway EM; Carmeliet P. 2008. Role of Gas6 in erythropoiesis and anemia in mice. J Clin Invest 118(2):583-96. [PubMed: 18188450]  [MGI Ref ID J:131177]

Bauer T; Zagorska A; Jurkin J; Yasmin N; Koffel R; Richter S; Gesslbauer B; Lemke G; Strobl H. 2012. Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med 209(11):2033-47. [PubMed: 23071254]  [MGI Ref ID J:190898]

Bellosta P; Zhang Q; Goff SP; Basilico C. 1997. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene 15(20):2387-97. [PubMed: 9395235]  [MGI Ref ID J:44193]

Bosurgi L; Bernink JH; Delgado Cuevas V; Gagliani N; Joannas L; Schmid ET; Booth CJ; Ghosh S; Rothlin CV. 2013. Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proc Natl Acad Sci U S A 110(32):13091-6. [PubMed: 23878224]  [MGI Ref ID J:200704]

Burstyn-Cohen T; Heeb MJ; Lemke G. 2009. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest 119(10):2942-53. [PubMed: 19729839]  [MGI Ref ID J:198769]

Burstyn-Cohen T; Lew ED; Traves PG; Burrola PG; Hash JC; Lemke G. 2012. Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis. Neuron 76(6):1123-32. [PubMed: 23259948]  [MGI Ref ID J:197656]

Carrera Silva EA; Chan PY; Joannas L; Errasti AE; Gagliani N; Bosurgi L; Jabbour M; Perry A; Smith-Chakmakova F; Mucida D; Cheroutre H; Burstyn-Cohen T; Leighton JA; Lemke G; Ghosh S; Rothlin CV. 2013. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity 39(1):160-70. [PubMed: 23850380]  [MGI Ref ID J:208244]

Chen Y; Wang H; Qi N; Wu H; Xiong W; Ma J; Lu Q; Han D. 2009. Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice. Reproduction 138(4):655-66. [PubMed: 19602523]  [MGI Ref ID J:157130]

Deng T; Zhang Y; Chen Q; Yan K; Han D. 2012. Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages. Immunology 135(1):40-50. [PubMed: 22043818]  [MGI Ref ID J:179716]

Gerloff J; Korshunov VA. 2012. Immune modulation of vascular resident cells by axl orchestrates carotid intima-media thickening. Am J Pathol 180(5):2134-43. [PubMed: 22538191]  [MGI Ref ID J:183990]

Hoehn HJ; Kress Y; Sohn A; Brosnan CF; Bourdon S; Shafit-Zagardo B. 2008. Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity. Brain Res 1240:1-11. [PubMed: 18804096]  [MGI Ref ID J:147638]

Ji R; Tian S; Lu HJ; Lu Q; Zheng Y; Wang X; Ding J; Li Q; Lu Q. 2013. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol 191(12):6165-77. [PubMed: 24244024]  [MGI Ref ID J:207107]

Korshunov VA; Mohan AM; Georger MA; Berk BC. 2006. Axl, a receptor tyrosine kinase, mediates flow-induced vascular remodeling. Circ Res 98(11):1446-52. [PubMed: 16627783]  [MGI Ref ID J:122626]

Li Q; Lu Q; Lu H; Tian S; Lu Q. 2013. Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death. PLoS One 8(6):e64812. [PubMed: 23840307]  [MGI Ref ID J:204335]

Lu Q; Lemke G. 2001. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293(5528):306-11. [PubMed: 11452127]  [MGI Ref ID J:70420]

Pierce A; Bliesner B; Xu M; Nielsen-Preiss S; Lemke G; Tobet S; Wierman ME. 2008. Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol 22(11):2481-95. [PubMed: 18787040]  [MGI Ref ID J:141251]

Pierce A; Xu M; Bliesner B; Liu Z; Richards J; Tobet S; Wierman ME. 2011. Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice. Mol Cell Endocrinol 339(1-2):151-8. [PubMed: 21539887]  [MGI Ref ID J:179535]

Qi N; Liu P; Zhang Y; Wu H; Chen Y; Han D. 2013. Development of a spontaneous liver disease resembling autoimmune hepatitis in mice lacking tyro3, axl and mer receptor tyrosine kinases. PLoS One 8(6):e66604. [PubMed: 23799121]  [MGI Ref ID J:204210]

Radic MZ; Shah K; Zhang W; Lu Q; Lemke G; Hilliard GM. 2006. Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol 176(1):68-74. [PubMed: 16365397]  [MGI Ref ID J:126253]

Rothlin CV; Ghosh S; Zuniga EI; Oldstone MB; Lemke G. 2007. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131(6):1124-36. [PubMed: 18083102]  [MGI Ref ID J:131447]

Sandahl M; Hunter DM; Strunk KE; Earp HS; Cook RS. 2010. Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation. BMC Dev Biol 10:122. [PubMed: 21192804]  [MGI Ref ID J:167986]

Seitz HM; Camenisch TD; Lemke G; Earp HS; Matsushima GK. 2007. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 178(9):5635-42. [PubMed: 17442946]  [MGI Ref ID J:145835]

Shang T; Zhang X; Wang T; Sun B; Deng T; Han D. 2011. Toll-like receptor-initiated testicular innate immune responses in mouse leydig cells. Endocrinology 152(7):2827-36. [PubMed: 21540291]  [MGI Ref ID J:174897]

Shankar SL; O'Guin K; Kim M; Varnum B; Lemke G; Brosnan CF; Shafit-Zagardo B. 2006. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. J Neurosci 26(21):5638-48. [PubMed: 16723520]  [MGI Ref ID J:182390]

Sharif MN; Sosic D; Rothlin CV; Kelly E; Lemke G; Olson EN; Ivashkiv LB. 2006. Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med 203(8):1891-901. [PubMed: 16831897]  [MGI Ref ID J:124396]

Sullivan BM; Welch MJ; Lemke G; Oldstone MB. 2013. Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? J Virol 87(7):4071-4. [PubMed: 23325690]  [MGI Ref ID J:197218]

Wang J; Zhang H; Young AG; Qiu R; Argalian S; Li X; Wu X; Lemke G; Lu Q. 2011. Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy. Stem Cells 29(10):1589-600. [PubMed: 21805534]  [MGI Ref ID J:212600]

Williams BJ; Craven RR; Earp HS; Kawula TH; Matsushima GK. 2009. TAM receptors are dispensable in the phagocytosis and killing of bacteria. Cell Immunol 259(2):128-34. [PubMed: 19625016]  [MGI Ref ID J:152808]

Williams JC; Wagner NJ; Earp HS; Vilen BJ; Matsushima GK. 2010. Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration. J Immunol 184(12):6637-48. [PubMed: 20483720]  [MGI Ref ID J:161155]

Wu H; Tang H; Chen Y; Wang H; Han D. 2008. High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev 75(12):1775-82. [PubMed: 18393392]  [MGI Ref ID J:142166]

Xiong W; Chen Y; Wang H; Wang H; Wu H; Lu Q; Han D. 2008. Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction 135(1):77-87. [PubMed: 18159085]  [MGI Ref ID J:133455]

Ye F; Han L; Lu Q; Dong W; Chen Z; Shao H; Kaplan HJ; Li Q; Lu Q. 2011. Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice. J Immunol 187(8):4178-86. [PubMed: 21918185]  [MGI Ref ID J:179310]

Ye F; Li Q; Ke Y; Lu Q; Han L; Kaplan HJ; Shao H; Lu Q. 2011. TAM receptor knockout mice are susceptible to retinal autoimmune induction. Invest Ophthalmol Vis Sci 52(7):4239-46. [PubMed: 21467176]  [MGI Ref ID J:181426]

Zhong Z; Wang Y; Guo H; Sagare A; Fernandez JA; Bell RD; Barrett TM; Griffin JH; Freeman RS; Zlokovic BV. 2010. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci 30(46):15521-34. [PubMed: 21084607]  [MGI Ref ID J:182379]

Zhu D; Wang Y; Singh I; Bell RD; Deane R; Zhong Z; Sagare A; Winkler EA; Zlokovic BV. 2010. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115(23):4963-72. [PubMed: 20348395]  [MGI Ref ID J:161551]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhile maintaining a live colony, these mice are bred as homozygotes.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)