Strain Name:

NOD.B10Sn-Idd5C57Bl/10SnJ/R193MrkTacJ

Stock Number:

012392

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This strain is one of a set of 9 NOD.B10 congenic Idd5 strains (Stock No. 008893, 008894, 004344, 012391, 012394, 012393, 012395, and 012396 that resulted by crossing segments of C57BL/10SnJ derived chromosome 1 into the NOD/MrkTac background. These strains may be useful to better understand the variation of diabetic resistance conferred by Idd loci; for studying long-range chromosome remodeling and may be useful for identifying diabetes susceptible candidate genes within the Idd5 subloci.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/MrkTac
Donor Strain C57BL/10SnJ
H2 Haplotypeg7
GenerationN16F?+F3p
Generation Definitions
 
Donating Investigator Linda Wicker,   University of Cambridge, UK

Description
This NOD/MrkTac congenic strain, commonly referred to as NOD.B10-Idd5R193, line 2574 contains a 16.2Mb genomic segment from the diabetes resistant strain C57BL/10SnJ (Stock No. 000666) introgressed into chromosome 1 and is defined within markers D1Mit124 (57.7Mb) and D1Mit180 (73.9Mb). The C57BL/10SnJ genomic segment includes Idd5.1 and recently identified Idd5.3. The major candidate gene for Idd5.1 is Ctla4. The Idd5.3 is defined to a 3.55Mb region. Within this region there are 11 annotated genes; including possible candidate genes IKAROS family zinc finger 2 (Ikzf2) and acyl-Coenzyme A dehydrogenase, long-chain (Acadl) Diabetes incidence is significantly protected among 7-month old females. Diabetes incidence among 7-month old females is reported to be 47%, compared with more than 80% in NOD controls or 62% in NOD.B10-Idd5.1 (Stock No. 012391) (Hunter, et al. 2007).

This strain may be useful for positional mapping and identifying candidate genes within the Idd5.3 region. This strain is useful for understanding the variation in diabetic resistance conferred by Idd loci, in particular the epistatic interactions of Idd5.1 alleles with alleles at Idd5.3

Development
This strain was produced by mating mice from NOD/MrkTac (NOD) to C57BL/10SnJ followed by 15 additional crosses to NOD with selection for chromosome 1, Idd5 markers. Siblings carrying the C57BL/10SnJ derived segments denoted by markers D1Mit124 (57.7Mb) through D1Mit180 (73.9Mb) were intercrossed to make homozygous. 5kSNP Chip Data, based on NCBI, build 37, identifies no C57BL/10SnJ genetic contamination of other chromosomes. The Type 1 Diabetes Resource received this strain in 2010.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Idd5.1C57BL/10SnJ allele
012391   NOD.B10Sn-Idd5.1C57BL/10SnJ/R46MrkTacJ
View Strains carrying   Idd5.1C57BL/10SnJ     (1 strain)

Strains carrying   Idd5.2C57BL/10SnJ allele
012396   NOD.B10Sn-Idd5.2C57BL/10SnJ Idd5.3C57BL/10SnJ/7341MrkTacJ
012394   NOD.B10Sn-Idd5.2C57BL/10SnJ/6146MrkTacJ
View Strains carrying   Idd5.2C57BL/10SnJ     (2 strains)

View Strains carrying   Idd5C57BL/10SnJ     (4 strains)

Strains carrying other alleles of Idd5.1
008894   NOD.B10Sn-Idd5C57BL/10SnJ/974MrkJ
View Strains carrying other alleles of Idd5.1     (1 strain)

Strains carrying other alleles of Idd5.2
008893   NOD.B10Sn-Idd5C57BL/10SnJ/1092MrkJ
008894   NOD.B10Sn-Idd5C57BL/10SnJ/974MrkJ
View Strains carrying other alleles of Idd5.2     (2 strains)

View Strains carrying other alleles of Idd5     (6 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
      NOD/ShiLtJ Non-MHC Congenics

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      Type 1 Diabetes

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Idd5C57BL/10SnJ
Allele Name C57BL/10SnJ
Allele Type QTL
Common Name(s) Idd5b10;
Strain of OriginC57BL/10SnJ
Gene Symbol and Name Idd5, insulin dependent diabetes susceptibility 5
Chromosome 1
Gene Common Name(s) Idd-5;
General Note Idd3 and Idd5 appear to interact additively. C57BL/6-derived alleles at Idd3 in combination with C57BL/10SnJ-derived alleles at Idd5 partially reverses autoimmune exocrinopathy markers on an NOD genetic background.
Molecular Note This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. [MGI Ref ID J:71276]
 
Allele Symbol Idd5.1C57BL/10SnJ
Allele Name C57BL/10SnJ
Allele Type QTL
Common Name(s) Idd5.1;
Strain of OriginC57BL/10SnJ
Gene Symbol and Name Idd5.1, insulin dependent diabetes susceptibility 5.1
Chromosome 1
Gene Common Name(s) Idd5a; insulin dependent diabetes susceptibility 5a;
Molecular Note This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. [MGI Ref ID J:88667]
 
Allele Symbol Idd5.2C57BL/10SnJ
Allele Name C57BL/10SnJ
Allele Type QTL
Common Name(s) Idd5.2;
Strain of OriginC57BL/10SnJ
Gene Symbol and Name Idd5.2, insulin dependent diabetes susceptibility 5.2
Chromosome 1
Gene Common Name(s) Idd5b; insulin dependent diabetes susceptibility 5b;
Molecular Note This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. [MGI Ref ID J:88667]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Hunter K; Rainbow D; Plagnol V; Todd JA; Peterson LB; Wicker LS. 2007. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol 179(12):8341-9. [PubMed: 18056379]  [MGI Ref ID J:143549]

Additional References

Idd5.1C57BL/10SnJ related

Araki M; Chung D; Liu S; Rainbow DB; Chamberlain G; Garner V; Hunter KM; Vijayakrishnan L; Peterson LB; Oukka M; Sharpe AH; Sobel R; Kuchroo VK; Wicker LS. 2009. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol 183(8):5146-57. [PubMed: 19783679]  [MGI Ref ID J:153599]

Dai YD; Marrero IG; Gros P; Zaghouani H; Wicker LS; Sercarz EE. 2009. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58(1):156-64. [PubMed: 18984740]  [MGI Ref ID J:146983]

Hamilton-Williams EE; Cheung J; Rainbow DB; Hunter KM; Wicker LS; Sherman LA. 2012. Cellular mechanisms of restored beta-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes 61(1):166-74. [PubMed: 22106155]  [MGI Ref ID J:191380]

Hill NJ; Lyons PA; Armitage N; Todd JA; Wicker LS; Peterson LB. 2000. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49(10):1744-7. [PubMed: 11016460]  [MGI Ref ID J:88667]

Kochupurakkal NM; Kruger AJ; Tripathi S; Zhu B; Adams LT; Rainbow DB; Rossini A; Greiner DL; Sayegh MH; Wicker LS; Guleria I. 2014. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One 9(2):e89561. [PubMed: 24586872]  [MGI Ref ID J:213816]

Lin X; Hamilton-Williams EE; Rainbow DB; Hunter KM; Dai YD; Cheung J; Peterson LB; Wicker LS; Sherman LA. 2013. Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes. J Immunol 190(7):3109-20. [PubMed: 23427248]  [MGI Ref ID J:194526]

Wicker LS; Chamberlain G; Hunter K; Rainbow D; Howlett S; Tiffen P; Clark J; Gonzalez-Munoz A; Cumiskey AM; Rosa RL; Howson JM; Smink LJ; Kingsnorth A; Lyons PA; Gregory S; Rogers J; Todd JA; Peterson LB. 2004. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol 173(1):164-73. [PubMed: 15210771]  [MGI Ref ID J:90924]

Idd5.2C57BL/10SnJ related

Dai YD; Marrero IG; Gros P; Zaghouani H; Wicker LS; Sercarz EE. 2009. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58(1):156-64. [PubMed: 18984740]  [MGI Ref ID J:146983]

Hamilton-Williams EE; Cheung J; Rainbow DB; Hunter KM; Wicker LS; Sherman LA. 2012. Cellular mechanisms of restored beta-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes 61(1):166-74. [PubMed: 22106155]  [MGI Ref ID J:191380]

Hill NJ; Lyons PA; Armitage N; Todd JA; Wicker LS; Peterson LB. 2000. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49(10):1744-7. [PubMed: 11016460]  [MGI Ref ID J:88667]

Kochupurakkal NM; Kruger AJ; Tripathi S; Zhu B; Adams LT; Rainbow DB; Rossini A; Greiner DL; Sayegh MH; Wicker LS; Guleria I. 2014. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One 9(2):e89561. [PubMed: 24586872]  [MGI Ref ID J:213816]

Lin X; Hamilton-Williams EE; Rainbow DB; Hunter KM; Dai YD; Cheung J; Peterson LB; Wicker LS; Sherman LA. 2013. Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes. J Immunol 190(7):3109-20. [PubMed: 23427248]  [MGI Ref ID J:194526]

Wicker LS; Chamberlain G; Hunter K; Rainbow D; Howlett S; Tiffen P; Clark J; Gonzalez-Munoz A; Cumiskey AM; Rosa RL; Howson JM; Smink LJ; Kingsnorth A; Lyons PA; Gregory S; Rogers J; Todd JA; Peterson LB. 2004. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol 173(1):164-73. [PubMed: 15210771]  [MGI Ref ID J:90924]

Idd5C57BL/10SnJ related

Brayer J; Lowry J; Cha S; Robinson CP; Yamachika S; Peck AB; Humphreys-Beher MG. 2000. Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol 27(8):1896-904. [PubMed: 10955330]  [MGI Ref ID J:71276]

Cornall RJ. 1993. Genetics of a multifactorial disease: autoimmune type 1 diabetes mellitus. Clin Sci (Colch) 84(3):257-62. [PubMed: 8384947]  [MGI Ref ID J:17906]

Cox SL; Stolp J; Hallahan NL; Counotte J; Zhang W; Serreze DV; Basten A; Silveira PA. 2010. Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a beta-cell neo-self-antigen in type 1 diabetes prone NOD mice. Eur J Immunol 40(12):3413-25. [PubMed: 21108464]  [MGI Ref ID J:174579]

Ghosh S; Palmer SM; Rodrigues NR; Cordell HJ; Hearne CM; Cornall RJ; Prins JB; McShane P; Lathrop GM; Peterson LB; Wicker LS; Todd JA. 1993. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nat Genet 4(4):404-9. [PubMed: 8401590]  [MGI Ref ID J:13557]

Hill NJ; Lyons PA; Armitage N; Todd JA; Wicker LS; Peterson LB. 2000. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49(10):1744-7. [PubMed: 11016460]  [MGI Ref ID J:88667]

Jiang W; Anderson MS; Bronson R; Mathis D; Benoist C. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202(6):805-15. [PubMed: 16172259]  [MGI Ref ID J:107432]

Kochupurakkal NM; Kruger AJ; Tripathi S; Zhu B; Adams LT; Rainbow DB; Rossini A; Greiner DL; Sayegh MH; Wicker LS; Guleria I. 2014. Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One 9(2):e89561. [PubMed: 24586872]  [MGI Ref ID J:213816]

Lin X; Hamilton-Williams EE; Rainbow DB; Hunter KM; Dai YD; Cheung J; Peterson LB; Wicker LS; Sherman LA. 2013. Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes. J Immunol 190(7):3109-20. [PubMed: 23427248]  [MGI Ref ID J:194526]

Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741]  [MGI Ref ID J:146982]

Motta V; Lejon K; Holmberg D. 2007. The NOD allele of the Idd5 locus on chromosome 1 mediates a non-cell-autonomous defect in negative selection of T cells. J Autoimmun 28(4):216-23. [PubMed: 17449224]  [MGI Ref ID J:125098]

Silveira PA; Chapman HD; Stolp J; Johnson E; Cox SL; Hunter K; Wicker LS; Serreze DV. 2006. Genes within the Idd5 and Idd9/11 Diabetes Susceptibility Loci Affect the Pathogenic Activity of B Cells in Nonobese Diabetic Mice. J Immunol 177(10):7033-41. [PubMed: 17082619]  [MGI Ref ID J:114754]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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