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| This strain is one of a set of 9 NOD.B10 congenic Idd5 strains (Stock No. 008893, 008894, 004344, 012391, 012392, 012393, 012394, and 012395 that resulted by crossing segments of C57BL/10SnJ derived chromosome 1 into the NOD/MrkTac background. These strains may be useful to better understand the variation of diabetic resistance conferred by Idd loci; for studying long-range chromosome remodeling and may be useful for identifying diabetes susceptible candidate genes within the Idd5 subloci. | ||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/MrkTac Donor Strain C57BL/10SnJ H2 Haplotype g7 Generation ?+F3pN1
Generation DefinitionsDonating Investigator Linda Wicker, University of Cambridge, UK Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcDescription
This NOD/MrkTac congenic strain, commonly referred to as NOD.B10-Idd5R7341, contains two genomic segments containing Idd5.2 and Idd5.3, from the diabetes resistant strain C57BL/10SnJ (Stock No. 000666) introgressed into chromosome 1. The C57BL/10SnJ genomic segments include Idd5.2 that contains major candidate gene Nramp1 and Idd5.3 containing major candidate gene Ikcf2. Diabetes incidence similar to NOD is not protected in this NOD.B10-Idd5.2, Idd5.3 strain. This strain may be useful for understanding the variation in diabetic resistance conferred by Idd loci, in particular the epistatic interactions of Idd5.2, Idd5.3 alleles with other Idd alleles.Development
This NOD/MrkTac congenic strain contains two C57BL/10SnJ (Stock No. 000666) derived genomic segments, introgressed into chromosome 1. The C57BL/10SnJ genomic segments include Idd5.2 and Idd5.3. The Idd5.2 region contains major candidate gene Nramp1 and the Idd5.3 region contains major candidate genes Ikoros family zinc finger 2 protein, Ikcf2, and acyl CoA dehydrogenase, Acadl. This strain was produced by mating published strains 6146 (Stock No. 012394) together with strain 6360 (Hunter, et al 2007). Siblings carrying the C57BL/10SnJ derived segments were intercrossed to make homozygous. NCBI based 5kSNP Chip Data identified no C57BL/10SnJ genetic contamination of other chromosomes. The Type 1 Diabetes Resource received this strain in 2010.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Idd5.2C57BL/10SnJ allele
012394 NOD.B10Sn-Idd5.2C57BL/10SnJ/6146MrkTacJ 012392 NOD.B10Sn-Idd5C57Bl/10SnJ/R193MrkTacJ View Strains carrying Idd5.2C57BL/10SnJ (2 strains)
012395 NOD.B10Sn-Idd5.3C57BL/10SnJ/7345MrkTacJ
008893 NOD.B10Sn-Idd5C57BL/10SnJ/1092MrkJ 008894 NOD.B10Sn-Idd5C57BL/10SnJ/974MrkJ
008893 NOD.B10Sn-Idd5C57BL/10SnJ/1092MrkJ 008894 NOD.B10Sn-Idd5C57BL/10SnJ/974MrkJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ Non-MHC Congenics
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
Type 1 Diabetes
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Idd5.2C57BL/10SnJ | ||
|---|---|---|---|
| Allele Name | C57BL/10SnJ | ||
| Allele Type | QTL | ||
| Common Name(s) | Idd5.2; | ||
| Strain of Origin | C57BL/10SnJ | ||
| Gene Symbol and Name | Idd5.2, insulin dependent diabetes susceptibility 5.2 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | Idd5b; insulin dependent diabetes susceptibility 5b; | ||
| Molecular Note | This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. [MGI Ref ID J:88667] | ||
| Allele Symbol | Idd5.3C57BL/10SnJ | ||
| Allele Name | C57BL/10SnJ | ||
| Allele Type | QTL | ||
| Common Name(s) | Idd5.3; | ||
| Strain of Origin | C57BL/10SnJ | ||
| Gene Symbol and Name | Idd5.3, insulin dependent diabetes susceptibility 5.3 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | Idd5c; insulin dependent diabetes susceptibility 5c; | ||
| Molecular Note | This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. [MGI Ref ID J:143549] | ||
References
References provided by MGI
Additional References
Idd5.2C57BL/10SnJ relatedIdd5.3C57BL/10SnJ relatedDai YD; Marrero IG; Gros P; Zaghouani H; Wicker LS; Sercarz EE. 2009. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58(1):156-64. [PubMed: 18984740] [MGI Ref ID J:146983]
Hamilton-Williams EE; Cheung J; Rainbow DB; Hunter KM; Wicker LS; Sherman LA. 2012. Cellular mechanisms of restored beta-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes 61(1):166-74. [PubMed: 22106155] [MGI Ref ID J:191380]
Hill NJ; Lyons PA; Armitage N; Todd JA; Wicker LS; Peterson LB. 2000. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes 49(10):1744-7. [PubMed: 11016460] [MGI Ref ID J:88667]
Hunter K; Rainbow D; Plagnol V; Todd JA; Peterson LB; Wicker LS. 2007. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol 179(12):8341-9. [PubMed: 18056379] [MGI Ref ID J:143549]
Lin X; Hamilton-Williams EE; Rainbow DB; Hunter KM; Dai YD; Cheung J; Peterson LB; Wicker LS; Sherman LA. 2013. Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes. J Immunol 190(7):3109-20. [PubMed: 23427248] [MGI Ref ID J:194526]
Wicker LS; Chamberlain G; Hunter K; Rainbow D; Howlett S; Tiffen P; Clark J; Gonzalez-Munoz A; Cumiskey AM; Rosa RL; Howson JM; Smink LJ; Kingsnorth A; Lyons PA; Gregory S; Rogers J; Todd JA; Peterson LB. 2004. Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol 173(1):164-73. [PubMed: 15210771] [MGI Ref ID J:90924]
Dai YD; Marrero IG; Gros P; Zaghouani H; Wicker LS; Sercarz EE. 2009. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58(1):156-64. [PubMed: 18984740] [MGI Ref ID J:146983]
Hamilton-Williams EE; Cheung J; Rainbow DB; Hunter KM; Wicker LS; Sherman LA. 2012. Cellular mechanisms of restored beta-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes 61(1):166-74. [PubMed: 22106155] [MGI Ref ID J:191380]
Hunter K; Rainbow D; Plagnol V; Todd JA; Peterson LB; Wicker LS. 2007. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol 179(12):8341-9. [PubMed: 18056379] [MGI Ref ID J:143549]
Lin X; Hamilton-Williams EE; Rainbow DB; Hunter KM; Dai YD; Cheung J; Peterson LB; Wicker LS; Sherman LA. 2013. Genetic Interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 Protective Loci in the Nonobese Diabetic Mouse Model of Type 1 Diabetes. J Immunol 190(7):3109-20. [PubMed: 23427248] [MGI Ref ID J:194526]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- This strain is included in the Type 1 Diabetes Repository collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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