Description

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N10F2 (28-JAN-10) Generation Definitions   Donating Investigator Dr. Ken Johnson,   JAX

Description
This congenic expresses the C57BL/6J derived sequence of Fscn2, rather than the Fscn2^ahl8 sequence, and has a resulting amelioration of the early onset hearing loss characteristic in DBA/2J mice. Distinct from the DBA/2J host background these congenic mice have click, 8 kHz, and 16 kHz ABR thresholds at 2 months of age that are equivalent to those of C57BL/6J, although the 32 kHz thresholds are elevated similar to those of DBA/2J. This congenic rescue is similar to that found in the transgenic rescue in DBA/2J-Tg(RP24-180N9)2Kjn/Kjn (stock #012440).

Development
This congenic was generated by repeatedly backcrossing the Fscn sequence from C57BL/6J onto DBA/2J until generation N10 and then intercrossing to make the C57BL/6J-derived interval homozygous on the DBA/2J background.

Related Strains

Strains carrying other alleles of Fscn2

009629	B6.D2-Fscn2ahl8/4Kjn
000671	DBA/2J
012440	DBA/2J-Tg(RP24-180N9)2Kjn/Kjn

View Strains carrying other alleles of Fscn2     (3 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Fscn2⁺ related

Sensorineural Research
Hearing Defects
      Age related hearing loss, control

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Fscn2+
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Fscn2, fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Chromosome		11
Gene Common Name(s)		C630046B20Rik; RFSN; RIKEN cDNA C630046B20 gene; RP30; age related hearing loss 8; ahl8;

Genotyping

Genotyping Information

Genotyping Protocols

Fscn2⁺, Pyrosequencing

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Shin JB; Longo-Guess CM; Gagnon LH; Saylor KW; Dumont RA; Spinelli KJ; Pagana JM; Wilmarth PA; David LL; Gillespie PG; Johnson KR. 2010. The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. J Neurosci 30(29):9683-94. [PubMed: 20660251]  [MGI Ref ID J:162868]

Additional References

Fscn2⁺ related

Yokokura S; Wada Y; Nakai S; Sato H; Yao R; Yamanaka H; Ito S; Sagara Y; Takahashi M; Nakamura Y; Tamai M; Noda T. 2005. Targeted disruption of FSCN2 gene induces retinopathy in mice. Invest Ophthalmol Vis Sci 46(8):2905-15. [PubMed: 16043865]  [MGI Ref ID J:103713]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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