Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male)   07-JUN-11 Species laboratory mouse Generation N17+N1F1 (09-MAR-11) Generation Definitions   Donating Investigator Dr. Philippe Soriano,   Mount Sinai School of Medicine

Description
Mice homozygous for this targeted mutation are viable, fertile and are grossly normal. Homozygous mutant mice exhibit defective T cell receptor signaling, a reduction in levels of tyrosine-phosphorylated proteins, failure to flux calcium in response to TCR cross-linking, and a reduction in production of calcium-related IL2. THY-1-induced proliferation is also reduced in thymocytes but not in splenic T cells. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A targeting vector containing a neomycin resistance cassette was used to disrupt a 3kb region containing exon 2. The construct was electroporated into 129S7/SvEvBrd-Hprt⁺ derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice. The mice were then backcrossed to C57BL/6J for 16 generations. Upon arrival at The Jackson Laboratory the mice were crossed to C57BL/6J once to establish the colony.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

Strains carrying   Fyn^tm1Sor allele

002271	129-Fyntm1Sor/J
002385	B6;129S7-Fyntm1Sor/J

View Strains carrying   Fyn^tm1Sor     (2 strains)

Strains carrying other alleles of Fyn

018154	B6N.129S2-Fyntm1Rmp/J
017005	FVB.Cg-Tg(KRT14-Fyn*)aJsey/J

View Strains carrying other alleles of Fyn     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Fyn^tm1Sor/Fyn^tm1Sor

        B6.129S7-Fyn^tm1Sor

• immune system phenotype
• abnormal CD4-positive T cell physiology
  • pronounced defects in TCR-initiated proliferation and production of Ifng, IL-4 and IL-2 upon stimulation with anti-CD3 or anti-CD3 plus anti-CD28   (MGI Ref ID J:93886)
  • some responses are partially corrected by addition of exogenous IL-2, but IL-4 production block is not relieved   (MGI Ref ID J:93886)
  • cells exhibit impaired IL-4 and IL-13 production upon stimulation with anti-CD3, anti-CD3 and anti-CD28 or PMA plus ionomycin   (MGI Ref ID J:93886)
• abnormal NK cell physiology
  • decreased killing of RMA-S, B16 and, to a lesser extent, YAC-1 cells   (MGI Ref ID J:187430)
  • reduced activating effect of 2B4 towards cytotoxicity   (MGI Ref ID J:187430)
  • reduced conjugation with RMA-S cells, less pronounced than in Sh2d1a^tm1Pls homozygotes   (MGI Ref ID J:187430)
• abnormal T cell proliferation   (MGI Ref ID J:93886)
• decreased IgE level
  • levels are dramatically reduced   (MGI Ref ID J:93886)
• decreased interferon-gamma secretion
  • in response to RMA-S   (MGI Ref ID J:187430)
• hematopoietic system phenotype
• abnormal T cell proliferation   (MGI Ref ID J:93886)
• cellular phenotype
• abnormal T cell proliferation   (MGI Ref ID J:93886)

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Fyn^tm1Sor/Fyn^tm1Sor

        either: 129S7/SvEvBrd-Fyn^tm1Sor or (involves: 129S7/SvEvBrd * C57BL/6J)

• immune system phenotype
• abnormal T cell clonal deletion
  • thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A   (MGI Ref ID J:2242)
• abnormal immune cell physiology
  • thymocytes and mature T cells fail to flux calcium to any large extent in response to TCR cross-linking   (MGI Ref ID J:2242)
• • abnormal T cell physiology
    • mature T cells fail to flux calcium to any large extent in response to TCR cross-linking   (MGI Ref ID J:2242)
  • • abnormal thymocyte activation
      • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)
    • decreased T cell proliferation
      • thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes   (MGI Ref ID J:2242)
  • increased IgG2a level
    • IgG2a is consistently elevated by 30-40%   (MGI Ref ID J:2242)
  • increased IgM level
    • consistently elevated by 30-40%   (MGI Ref ID J:2242)
• decreased interleukin-2 secretion
  • production of IL-2 by splenic T cells is reduced in response to TCR activation   (MGI Ref ID J:2242)
• behavior/neurological phenotype
• abnormal spatial learning
  • show impaired spatial learning in Morris water maze test   (MGI Ref ID J:3417)
• nervous system phenotype
• abnormal dentate gyrus morphology
  • exhibit an increased number of granule cells in the dentate gyrus   (MGI Ref ID J:3417)
  • exhibit undulation of the granule cell layer   (MGI Ref ID J:3417)
• abnormal hippocampus pyramidal cell layer
  • undulation of the pyramidal cell layer in the CA3 region and in the dentate gyrus   (MGI Ref ID J:3417)
• • abnormal hippocampus pyramidal cell morphology
    • apical dendrites of CA1 pyramidal neurons appear less tightly organized   (MGI Ref ID J:3417)
  • • increased hippocampus pyramidal cell number
      • exhibit an increased number of pyramidal cells in the CA3 region   (MGI Ref ID J:3417)
• reduced long term potentiation
  • LTP is blunted in the CA1 neurons of hippocampal slices, in both the field EPSP and in the population spike, even though synaptic transmission and two short-term forms of synaptic plasticity, paired-pulse facilitation and post-tetanic   (MGI Ref ID J:3417)
• hematopoietic system phenotype
• abnormal T cell clonal deletion
  • thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A   (MGI Ref ID J:2242)
• abnormal thymocyte activation
  • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)
• decreased T cell proliferation
  • thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes   (MGI Ref ID J:2242)
• cellular phenotype
• abnormal T cell clonal deletion
  • thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A   (MGI Ref ID J:2242)
• abnormal thymocyte activation
  • proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional   (MGI Ref ID J:2242)
• decreased T cell proliferation
  • thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes   (MGI Ref ID J:2242)

Fyn^tm1Sor/Fyn^tm1Sor

        involves: 129S7/SvEvBrd * C57BL/6J

• nervous system phenotype
• abnormal hippocampus morphology   (MGI Ref ID J:80637)
• • abnormal dentate gyrus morphology
    • abnormal arrangement of rostral dentate gyrus   (MGI Ref ID J:80637)
  • abnormal hippocampus pyramidal cell layer
    • CA1 pyramidal cells are less tightly packed   (MGI Ref ID J:80637)
    • caudal CA3 pyramidal cell regions shows an abnormal arrangement   (MGI Ref ID J:80637)
  • • abnormal hippocampus pyramidal cell morphology
      • dendritic regions of pyramidal cells are narrow and length of the apical dendrites is shortened   (MGI Ref ID J:80637)
    • • ectopic hippocampus pyramidal cells
        • ectopic pyramidal cells are frequently seen   (MGI Ref ID J:80637)
• abnormal myelination
  • in the forebrain from P14 to P385, a myelin deficit is observed; at P26, deficit is 52% compared to controls   (MGI Ref ID J:109485)
  • myelin basic protein content in the brain is significantly reduced with a magnitude of 40%   (MGI Ref ID J:109485)
• abnormal optic nerve morphology
  • there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type   (MGI Ref ID J:109485)
• decreased corpus callosum size
  • thickness of corpus callosum is reduced compared to wild-type   (MGI Ref ID J:109485)
• reduced long term potentiation
  • exhibit age-dependent impairment of LTP that appears only when homozygotes are over 10 weeks of age   (MGI Ref ID J:80637)
• vision/eye phenotype
• abnormal optic nerve morphology
  • there is a 15% reduction in cross-sectional area of the optic nerve compared to wild-type   (MGI Ref ID J:109485)

Fyn^tm1Sor/Fyn^tm1Sor

        involves: 129S7/SvEvBrd

• immune system phenotype
• abnormal chemokine level
  • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type   (MGI Ref ID J:80658)
• abnormal macrophage physiology
  • fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 90% compared to in wild-type cells   (MGI Ref ID J:80658)
  • however, response to zymosan is normal   (MGI Ref ID J:80658)
• homeostasis/metabolism phenotype
• abnormal chemokine level
  • fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced to 75% of wild-type   (MGI Ref ID J:80658)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Oncogenes

Developmental Biology Research
Neurodevelopmental Defects

Immunology, Inflammation and Autoimmunity Research
T Cell Receptor Signaling Defects

Neurobiology Research
Behavioral and Learning Defects
Neurodevelopmental Defects

Fyn^tm1Sor related

Cancer Research
Oncogenes

Immunology, Inflammation and Autoimmunity Research
T Cell Receptor Signaling Defects

Neurobiology Research
Behavioral and Learning Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Fyntm1Sor
Allele Name		targeted mutation 1, Philippe Soriano
Allele Type		Targeted (knock-out)
Common Name(s)		fyn-;
Mutation Made By		Dr. Philippe Soriano,   Mount Sinai School of Medicine
Strain of Origin		129S7/SvEvBrd-Hprt<+>
ES Cell Line Name		AB1
ES Cell Line Strain		129S7/SvEvBrd-Hprt<+>
Gene Symbol and Name		Fyn, Fyn proto-oncogene
Chromosome		10
Gene Common Name(s)		AI448320; AW552119; SLK; SYN; Src Kinase p59; expressed sequence AI448320; expressed sequence AW552119; p59-FYN;
Molecular Note		Replacement of a 3kb fragment containing the first coding exon of the gene with a neomycin cassette. [MGI Ref ID J:2242] [MGI Ref ID J:97095]

Genotyping

Genotyping Information

Genotyping Protocols

Fyn^tm1Sor, Melt Curve Analysis
Fyn^tm1Sor, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Stein PL; Lee HM; Rich S; Soriano P. 1992. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70(5):741-50. [PubMed: 1387588]  [MGI Ref ID J:2242]

Additional References

Fyn^tm1Sor related

Arnaud L; Ballif BA; Forster E; Cooper JA. 2003. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol 13(1):9-17. [PubMed: 12526739]  [MGI Ref ID J:109820]

Assarsson E; Kambayashi T; Sandberg JK; Hong S; Taniguchi M; Van Kaer L; Ljunggren HG; Chambers BJ. 2000. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J Immunol 165(7):3673-9. [PubMed: 11034371]  [MGI Ref ID J:118029]

Audard V; Zhang SY; Copie-Bergman C; Rucker-Martin C; Ory V; Candelier M; Baia M; Lang P; Pawlak A; Sahali D. 2010. Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes. Blood 115(18):3756-62. [PubMed: 20200355]  [MGI Ref ID J:160246]

Babus LW; Little EM; Keenoy KE; Minami SS; Chen E; Song JM; Caviness J; Koo SY; Pak DT; Rebeck GW; Turner RS; Hoe HS. 2011. Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res 1415:96-102. [PubMed: 21872217]  [MGI Ref ID J:176593]

Ballif BA; Arnaud L; Cooper JA. 2003. Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Res Mol Brain Res 117(2):152-9. [PubMed: 14559149]  [MGI Ref ID J:115650]

Bastie CC; Zong H; Xu J; Busa B; Judex S; Kurland IJ; Pessin JE. 2007. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metab 5(5):371-81. [PubMed: 17488639]  [MGI Ref ID J:129861]

Beggs HE; Soriano P; Maness PF. 1994. NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice. J Cell Biol 127(3):825-33. [PubMed: 7962063]  [MGI Ref ID J:21120]

Biffiger K; Bartsch S; Montag D; Aguzzi A; Schachner M; Bartsch U. 2000. Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase. J Neurosci 20(19):7430-7. [PubMed: 11007902]  [MGI Ref ID J:77301]

Bloch-Queyrat C; Fondaneche MC; Chen R; Yin L; Relouzat F; Veillette A; Fischer A; Latour S. 2005. Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn. J Exp Med 202(1):181-92. [PubMed: 15998796]  [MGI Ref ID J:100630]

Bock HH; Herz J. 2003. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol 13(1):18-26. [PubMed: 12526740]  [MGI Ref ID J:109819]

Brackenbury WJ; Davis TH; Chen C; Slat EA; Detrow MJ; Dickendesher TL; Ranscht B; Isom LL. 2008. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci 28(12):3246-56. [PubMed: 18354028]  [MGI Ref ID J:133207]

Cai H; Smith DA; Memarzadeh S; Lowell CA; Cooper JA; Witte ON. 2011. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A 108(16):6579-84. [PubMed: 21464326]  [MGI Ref ID J:171364]

Cannons JL; Wu JZ; Gomez-Rodriguez J; Zhang J; Dong B; Liu Y; Shaw S; Siminovitch KA; Schwartzberg PL. 2010. Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol 185(5):2819-27. [PubMed: 20668219]  [MGI Ref ID J:163263]

Cannons JL; Yu LJ; Hill B; Mijares LA; Dombroski D; Nichols KE; Antonellis A; Koretzky GA; Gardner K; Schwartzberg PL. 2004. SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity 21(5):693-706. [PubMed: 15539155]  [MGI Ref ID J:93887]

Cannons JL; Yu LJ; Jankovic D; Crotty S; Horai R; Kirby M; Anderson S; Cheever AW; Sher A; Schwartzberg PL. 2006. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med 203(6):1551-65. [PubMed: 16754717]  [MGI Ref ID J:124375]

Chan B; Lanyi A; Song HK; Griesbach J; Simarro-Grande M; Poy F; Howie D; Sumegi J; Terhorst C; Eck MJ. 2003. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol 5(2):155-60. [PubMed: 12545174]  [MGI Ref ID J:109312]

Chari R; Kim S; Murugappan S; Sanjay A; Daniel JL; Kunapuli SP. 2009. Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood 114(14):3056-63. [PubMed: 19587372]  [MGI Ref ID J:153266]

Charles N; Watford WT; Ramos HL; Hellman L; Oettgen HC; Gomez G; Ryan JJ; O'Shea JJ; Rivera J. 2009. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity 30(4):533-43. [PubMed: 19362019]  [MGI Ref ID J:147963]

Chen K; Li W; Major J; Rahaman SO; Febbraio M; Silverstein RL. 2011. Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. Blood 117(21):5744-50. [PubMed: 21427288]  [MGI Ref ID J:173265]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

Chin J; Palop JJ; Yu GQ; Kojima N; Masliah E; Mucke L. 2004. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci 24(19):4692-7. [PubMed: 15140940]  [MGI Ref ID J:96892]

Chu DH; van Oers NS; Malissen M; Harris J; Elder M; Weiss A. 1999. Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J Immunol 163(5):2610-20. [PubMed: 10453000]  [MGI Ref ID J:57092]

Criscuoli ML; Nguyen M; Eliceiri BP. 2005. Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability. Blood 105(4):1508-14. [PubMed: 15486073]  [MGI Ref ID J:95907]

Dao T; Guo D; Ploss A; Stolzer A; Saylor C; Boursalian TE; Im JS; Sant'Angelo DB. 2004. Development of CD1d-restricted NKT cells in the mouse thymus. Eur J Immunol 34(12):3542-52. [PubMed: 15549774]  [MGI Ref ID J:94598]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davidson D; Schraven B; Veillette A. 2007. PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol 27(5):1960-73. [PubMed: 17210649]  [MGI Ref ID J:118860]

Davidson D; Shi X; Zhang S; Wang H; Nemer M; Ono N; Ohno S; Yanagi Y; Veillette A. 2004. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity 21(5):707-17. [PubMed: 15539156]  [MGI Ref ID J:93886]

De Fazio SR; Warner CM. 2007. Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn. Am J Reprod Immunol 58(4):315-24. [PubMed: 17845201]  [MGI Ref ID J:149050]

Derkinderen P; Toutant M; Kadare G; Ledent C; Parmentier M; Girault JA. 2001. Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus. J Biol Chem 276(41):38289-96. [PubMed: 11468287]  [MGI Ref ID J:120418]

Dey N; Crosswell HE; De P; Parsons R; Peng Q; Su JD; Durden DL. 2008. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res 68(6):1862-71. [PubMed: 18339867]  [MGI Ref ID J:133323]

Dong Z; Davidson D; Perez-Quintero LA; Kurosaki T; Swat W; Veillette A. 2012. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity 36(6):974-85. [PubMed: 22683124]  [MGI Ref ID J:187430]

Donlin LT; Roman CA; Adlam M; Regelmann AG; Alexandropoulos K. 2002. Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin. J Immunol 169(12):6900-9. [PubMed: 12471123]  [MGI Ref ID J:118421]

Dutta M; Schwartzberg PL. 2012. Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108. J Immunol 188(7):3031-41. [PubMed: 22393150]  [MGI Ref ID J:183088]

Eberl G; Lowin-Kropf B; MacDonald HR. 1999. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 163(8):4091-4. [PubMed: 10510341]  [MGI Ref ID J:57985]

Eliceiri BP; Paul R; Schwartzberg PL; Hood JD; Leng J; Cheresh DA. 1999. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 4(6):915-24. [PubMed: 10635317]  [MGI Ref ID J:59158]

Engel I; Murre C. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 23(1):202-11. [PubMed: 14685278]  [MGI Ref ID J:115665]

Falanga YT; Chaimowitz NS; Charles N; Finkelman FD; Pullen NA; Barbour S; Dholaria K; Faber T; Kolawole M; Huang B; Odom S; Rivera J; Carlyon J; Conrad DH; Spiegel S; Oskeritzian CA; Ryan JJ. 2012. Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol 188(9):4360-8. [PubMed: 22450804]  [MGI Ref ID J:188465]

Filby A; Seddon B; Kleczkowska J; Salmond R; Tomlinson P; Smida M; Lindquist JA; Schraven B; Zamoyska R. 2007. Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol 179(7):4635-44. [PubMed: 17878361]  [MGI Ref ID J:152346]

Frossi B; Rivera J; Hirsch E; Pucillo C. 2007. Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol 178(4):2549-55. [PubMed: 17277164]  [MGI Ref ID J:143971]

Gadue P; Morton N; Stein PL. 1999. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-96. [PubMed: 10523617]  [MGI Ref ID J:110943]

Gadue P; Yin L; Jain S; Stein PL. 2004. Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny. J Immunol 172(10):6093-100. [PubMed: 15128794]  [MGI Ref ID J:89871]

Garcia-Roman J; Ibarra-Sanchez A; Lamas M; Gonzalez Espinosa C. 2010. VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells. Biochem Biophys Res Commun 401(2):262-7. [PubMed: 20850416]  [MGI Ref ID J:165846]

Gomez G; Gonzalez-Espinosa C; Odom S; Baez G; Cid ME; Ryan JJ; Rivera J. 2005. Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol 175(11):7602-10. [PubMed: 16301670]  [MGI Ref ID J:122154]

Grant SG; Karl KA; Kiebler MA; Kandel ER. 1995. Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev 9(15):1909-21. [PubMed: 7544314]  [MGI Ref ID J:28276]

Grant SG; O'Dell TJ; Karl KA; Stein PL; Soriano P; Kandel ER. 1992. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice [see comments] Science 258(5090):1903-10. [PubMed: 1361685]  [MGI Ref ID J:3417]

Greenberg RS; Bernstein AM; Benezra M; Gelman IH; Taliana L; Masur SK. 2006. FAK-dependent regulation of myofibroblast differentiation. FASEB J 20(7):1006-8. [PubMed: 16585062]  [MGI Ref ID J:111499]

Hager E; Hawwari A; Matsuda JL; Krangel MS; Gapin L. 2007. Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. J Immunol 179(4):2228-34. [PubMed: 17675483]  [MGI Ref ID J:151224]

Hoe HS; Minami SS; Makarova A; Lee J; Hyman BT; Matsuoka Y; Rebeck GW. 2008. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem 283(10):6288-99. [PubMed: 18089558]  [MGI Ref ID J:134018]

Huang J; Lo PF; Zal T; Gascoigne NR; Smith BA; Levin SD; Grey HM. 2002. CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci U S A 99(14):9369-73. [PubMed: 12077322]  [MGI Ref ID J:126523]

Huerta PT; Scearce KA; Farris SM; Empson RM; Prusky GT. 1996. Preservation of spatial learning in fyn tyrosine kinase knockout mice. Neuroreport 7(10):1685-9. [PubMed: 8904782]  [MGI Ref ID J:36651]

Jurd R; Tretter V; Walker J; Brandon NJ; Moss SJ. 2010. Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci 44(2):129-34. [PubMed: 20233604]  [MGI Ref ID J:164138]

Kennedy DJ; Kuchibhotla S; Westfall KM; Silverstein RL; Morton RE; Febbraio M. 2011. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res 89(3):604-13. [PubMed: 21088116]  [MGI Ref ID J:186882]

Kim JK; Klinger M; Benjamin J; Xiao Y; Erle DJ; Littman DR; Killeen N. 2009. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One 4(8):e6580. [PubMed: 19668367]  [MGI Ref ID J:152472]

Kim S; Kunapuli SP. 2011. Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. J Biol Chem 286(27):24170-9. [PubMed: 21592972]  [MGI Ref ID J:174988]

Kitaura J; Eto K; Kinoshita T; Kawakami Y; Leitges M; Lowell CA; Kawakami T. 2005. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol 174(8):4495-504. [PubMed: 15814670]  [MGI Ref ID J:98164]

Klinghoffer RA; Sachsenmaier C; Cooper JA; Soriano P. 1999. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18(9):2459-71. [PubMed: 10228160]  [MGI Ref ID J:54973]

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Lovatt M; Filby A; Parravicini V; Werlen G; Palmer E; Zamoyska R. 2006. Lck Regulates the Threshold of Activation in Primary T Cells, While both Lck and Fyn Contribute to the Magnitude of the Extracellular Signal-Related Kinase Response. Mol Cell Biol 26(22):8655-65. [PubMed: 16966372]  [MGI Ref ID J:114668]

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Martin-Cofreces NB; Sancho D; Fernandez E; Vicente-Manzanares M; Gordon-Alonso M; Montoya MC; Michel F; Acuto O; Alarcon B; Sanchez-Madrid F. 2006. Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR. J Immunol 176(7):4201-7. [PubMed: 16547257]  [MGI Ref ID J:129875]

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Quek LS; Pasquet JM; Hers I; Cornall R; Knight G; Barnes M; Hibbs ML; Dunn AR; Lowell CA; Watson SP. 2000. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood 96(13):4246-53. [PubMed: 11110698]  [MGI Ref ID J:110337]

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