Strain Name:

B6;129S7-Lrp1tm2Her/J

Stock Number:

012604

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
This LRPflox strain may be useful for studying physiological role of LRP in the uptake of cholesterol-rich lipoproteins from circulation and in maintenance of plasma lipid homeostasis.

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   02-NOV-11
Specieslaboratory mouse
GenerationF?+F13 (10-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Joachim Herz,   Univ of Texas Southwest Med Ctr Dallas

Description
These LRPflox/flox mutant mice possess a floxed Neo cassette and a single loxP sites downstream of exon 2 of the targeted low-density lipoprotein (LDL) receptor-related protein (LRP) 1 gene, Lrp1. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, the resulting offspring will have exons 1 and 2 deleted in the cre-expressing tissue, resulting in inactivation of Lrp1 gene function. This strain may be useful for studying physiological role of LRP in the uptake of cholesterol-rich lipoproteins from circulation and in maintenance of plasma lipid homeostasis.

Development
A targeting vector was designed to insert a loxP-flanked neomycin resistance (neo) cassette upstream of the 5' initiation site, and a single loxP site downstream of exon 2 of the low-density lipoprotein (LDL) receptor-related protein (LRP) 1 gene, Lrp1. The construct was electroporated into 129S7/SvEvBrd-derived JH1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts and resulting chimeric mice were bred to C57BL/6 to establish a colony. Upon arrival at The Jackson Laboratory, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Lrp1
022778   B6N(Cg)-Lrp1tm1.1(KOMP)Wtsi/J
018185   C57BL/6J-Lrp1b2b1554Clo/J
View Strains carrying other alleles of Lrp1     (2 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lrp1tm2Her/Lrp1tm2Her

        involves: 129S7/SvEvBrd   (conditional)
  • liver/biliary system phenotype
  • abnormal liver physiology
    • impaired ability to clear 125I-labeled alpha2-macroglobulin from the plasma after adenoviral cre injection into the liver   (MGI Ref ID J:76281)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • unlike in double mutant mice that are also null for Ldlr , adenoviral cre infection does not alter circulating apolipoprotein levels or the plasma cholesterol profile   (MGI Ref ID J:67929)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cardiovascular Research
Hypercholesterolemia
Other
      altered fat metabolism

Metabolism Research
Lipid Metabolism

Neurobiology Research
Alzheimer's Disease

Research Tools
Cre-lox System
      loxP-flanked Sequences

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lrp1tm2Her
Allele Name targeted mutation 2, Joachim Herz
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) LRPflox; lrplox;
Mutation Made ByDr. Joachim Herz,   Univ of Texas Southwest Med Ctr Dallas
Strain of Origin129S7/SvEvBrd
Gene Symbol and Name Lrp1, low density lipoprotein receptor-related protein 1
Chromosome 10
Gene Common Name(s) A2MR; A2mr; AI316852; APOER; APR; CD91; IGFBP3R; LRP; LRP1A; Mutant line 1554; TGFBR5; alpha-2-macroglobulin receptor; b2b1554Clo; expressed sequence AI316852;
Molecular Note A loxP-flanked PGK-neomycin selection cassette was inserted 240 bp upstream of the transcription initiation site, and a third loxP site was inserted 3' to exon 2 in intron 2. [MGI Ref ID J:76281]

Genotyping

Genotyping Information

Genotyping Protocols

Lrp1tm2Her, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Lrp1tm2Her related

Basford JE; Moore ZW; Zhou L; Herz J; Hui DY. 2009. Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation. Arterioscler Thromb Vasc Biol 29(11):1772-8. [PubMed: 19729608]  [MGI Ref ID J:167799]

Basford JE; Wancata L; Hofmann SM; Silva RA; Davidson WS; Howles PN; Hui DY. 2011. Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice. J Biol Chem 286(15):13079-87. [PubMed: 21343303]  [MGI Ref ID J:171132]

Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. [PubMed: 12690199]  [MGI Ref ID J:82871]

Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS ONE 2(5):e448. [PubMed: 17505534]  [MGI Ref ID J:129347]

Bovenschen N; Herz J; Grimbergen JM; Lenting PJ; Havekes LM; Mertens K; van Vlijmen BJ. 2003. Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency. Blood 101(10):3933-9. [PubMed: 12522008]  [MGI Ref ID J:83443]

Bovenschen N; Mertens K; Hu L; Havekes LM; van Vlijmen BJ. 2005. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood 106(3):906-12. [PubMed: 15840700]  [MGI Ref ID J:117317]

Bovenschen N; van Dijk KW; Havekes LM; Mertens K; van Vlijmen BJ. 2004. Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice. Br J Haematol 126(5):722-5. [PubMed: 15327526]  [MGI Ref ID J:109394]

Carlo AS; Gustafsen C; Mastrobuoni G; Nielsen MS; Burgert T; Hartl D; Rohe M; Nykjaer A; Herz J; Heeren J; Kempa S; Petersen CM; Willnow TE. 2013. The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-beta peptide in the brain. J Neurosci 33(1):358-70. [PubMed: 23283348]  [MGI Ref ID J:193915]

Espirito Santo SM; Pires NM; Boesten LS; Gerritsen G; Bovenschen N; van Dijk KW; Jukema JW; Princen HM; Bensadoun A; Li WP; Herz J; Havekes LM; van Vlijmen BJ. 2004. Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood 103(10):3777-82. [PubMed: 14739216]  [MGI Ref ID J:90547]

Galvan MD; Foreman DB; Zeng E; Tan JC; Bohlson SS. 2012. Complement component C1q regulates macrophage expression of Mer tyrosine kinase to promote clearance of apoptotic cells. J Immunol 188(8):3716-23. [PubMed: 22422887]  [MGI Ref ID J:184063]

Gaultier A; Arandjelovic S; Niessen S; Overton CD; Linton MF; Fazio S; Campana WM; Cravatt BF 3rd; Gonias SL. 2008. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 111(11):5316-25. [PubMed: 18369152]  [MGI Ref ID J:136163]

Gonzales JC; Gordts PL; Foley EM; Esko JD. 2013. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest 123(6):2742-51. [PubMed: 23676495]  [MGI Ref ID J:201440]

Hennen E; Safina D; Haussmann U; Worsdorfer P; Edenhofer F; Poetsch A; Faissner A. 2013. A LewisX glycoprotein screen identifies the low density lipoprotein receptor-related protein 1 (LRP1) as a modulator of oligodendrogenesis in mice. J Biol Chem 288(23):16538-45. [PubMed: 23615909]  [MGI Ref ID J:199606]

Hofmann SM; Zhou L; Perez-Tilve D; Greer T; Grant E; Wancata L; Thomas A; Pfluger PT; Basford JE; Gilham D; Herz J; Tschop MH; Hui DY. 2007. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 117(11):3271-82. [PubMed: 17948131]  [MGI Ref ID J:127398]

Hu L; Boesten LS; May P; Herz J; Bovenschen N; Huisman MV; Berbee JF; Havekes LM; van Vlijmen BJ; Tamsma JT. 2006. Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol 26(12):2710-5. [PubMed: 17038633]  [MGI Ref ID J:129557]

Hu L; van der Hoogt CC; Espirito Santo SM; Out R; Kypreos KE; van Vlijmen BJ; Van Berkel TJ; Romijn JA; Havekes LM; van Dijk KW; Rensen PC. 2008. The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI. J Lipid Res 49(7):1553-61. [PubMed: 18367731]  [MGI Ref ID J:138462]

Kanekiyo T; Cirrito JR; Liu CC; Shinohara M; Li J; Schuler DR; Shinohara M; Holtzman DM; Bu G. 2013. Neuronal clearance of amyloid-beta by endocytic receptor LRP1. J Neurosci 33(49):19276-83. [PubMed: 24305823]  [MGI Ref ID J:204149]

Kanekiyo T; Liu CC; Shinohara M; Li J; Bu G. 2012. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta. J Neurosci 32(46):16458-65. [PubMed: 23152628]  [MGI Ref ID J:192453]

Laatsch A; Panteli M; Sornsakrin M; Hoffzimmer B; Grewal T; Heeren J. 2012. Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E. PLoS One 7(1):e29385. [PubMed: 22238606]  [MGI Ref ID J:184330]

Lillis AP; Greenlee MC; Mikhailenko I; Pizzo SV; Tenner AJ; Strickland DK; Bohlson SS. 2008. Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis. J Immunol 181(1):364-73. [PubMed: 18566402]  [MGI Ref ID J:137404]

Liu Q; Trotter J; Zhang J; Peters MM; Cheng H; Bao J; Han X; Weeber EJ; Bu G. 2010. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J Neurosci 30(50):17068-78. [PubMed: 21159977]  [MGI Ref ID J:167724]

Liu Q; Zerbinatti CV; Zhang J; Hoe HS; Wang B; Cole SL; Herz J; Muglia L; Bu G. 2007. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. [PubMed: 17920016]  [MGI Ref ID J:126954]

Liu Q; Zhang J; Zerbinatti C; Zhan Y; Kolber BJ; Herz J; Muglia LJ; Bu G. 2011. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biol 9(1):e1000575. [PubMed: 21264353]  [MGI Ref ID J:170131]

May P; Rohlmann A; Bock HH; Zurhove K; Marth JD; Schomburg ED; Noebels JL; Beffert U; Sweatt JD; Weeber EJ; Herz J. 2004. Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice. Mol Cell Biol 24(20):8872-83. [PubMed: 15456862]  [MGI Ref ID J:93329]

Muratoglu SC; Belgrave S; Lillis AP; Migliorini M; Robinson S; Smith E; Zhang L; Strickland DK. 2011. Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-beta signaling pathway. PLoS One 6(12):e28846. [PubMed: 22174911]  [MGI Ref ID J:182253]

Nakajima C; Kulik A; Frotscher M; Herz J; Schafer M; Bock HH; May P. 2013. Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. J Biol Chem 288(30):21909-23. [PubMed: 23760271]  [MGI Ref ID J:201767]

Orita S; Henry K; Mantuano E; Yamauchi K; De Corato A; Ishikawa T; Feltri ML; Wrabetz L; Gaultier A; Pollack M; Ellisman M; Takahashi K; Gonias SL; Campana WM. 2013. Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain. J Neurosci 33(13):5590-602. [PubMed: 23536074]  [MGI Ref ID J:196586]

Overton CD; Yancey PG; Major AS; Linton MF; Fazio S. 2007. Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res 100(5):670-7. [PubMed: 17303763]  [MGI Ref ID J:133698]

Rastegarlari G; Pegon JN; Casari C; Odouard S; Navarrete AM; Saint-Lu N; van Vlijmen BJ; Legendre P; Christophe OD; Denis CV; Lenting PJ. 2012. Macrophage LRP1 contributes to the clearance of von Willebrand factor. Blood 119(9):2126-34. [PubMed: 22234691]  [MGI Ref ID J:182558]

Rohlmann A; Gotthardt M; Hammer RE; Herz J. 1998. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest 101(3):689-95. [PubMed: 9449704]  [MGI Ref ID J:67929]

Rohlmann A; Gotthardt M; Willnow TE; Hammer RE; Herz J. 1996. Sustained somatic gene inactivation by viral transfer of Cre recombinase. Nat Biotechnol 14(11):1562-5. [PubMed: 9634821]  [MGI Ref ID J:76281]

Staudt ND; Jo M; Hu J; Bristow JM; Pizzo DP; Gaultier A; Vandenberg SR; Gonias SL. 2013. Myeloid Cell Receptor LRP1/CD91 Regulates Monocyte Recruitment and Angiogenesis in Tumors. Cancer Res 73(13):3902-12. [PubMed: 23633492]  [MGI Ref ID J:199015]

Tadokoro T; Ikekita M; Toda T; Ito H; Sato T; Nakatani R; Hamaguchi Y; Furukawa K. 2009. Involvement of Galectin-3 with vascular cell adhesion molecule-1 in growth regulation of mouse BALB/3T3 cells. J Biol Chem 284(51):35556-63. [PubMed: 19858221]  [MGI Ref ID J:158313]

Terrand J; Bruban V; Zhou L; Gong W; El Asmar Z; May P; Zurhove K; Haffner P; Philippe C; Woldt E; Matz RL; Gracia C; Metzger D; Auwerx J; Herz J; Boucher P. 2009. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J Biol Chem 284(1):381-8. [PubMed: 18990694]  [MGI Ref ID J:146007]

Vasandani C; Kafrouni AI; Caronna A; Bashmakov Y; Gotthardt M; Horton JD; Spady DK. 2002. Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice. J Lipid Res 43(5):772-84. [PubMed: 11971949]  [MGI Ref ID J:124748]

Xu G; Green CC; Fromholt SE; Borchelt DR. 2012. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice. Alzheimers Res Ther 4(2):12. [PubMed: 22537779]  [MGI Ref ID J:190171]

Yancey PG; Blakemore J; Ding L; Fan D; Overton CD; Zhang Y; Linton MF; Fazio S. 2010. Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Arterioscler Thromb Vasc Biol 30(4):787-95. [PubMed: 20150557]  [MGI Ref ID J:172263]

Zhang C; An J; Strickland DK; Yepes M. 2009. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol 174(2):586-94. [PubMed: 19147818]  [MGI Ref ID J:144185]

Zhou L; Choi HY; Li WP; Xu F; Herz J. 2009. LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One 4(8):e6853. [PubMed: 19718435]  [MGI Ref ID J:152391]

Zhou L; Takayama Y; Boucher P; Tallquist MD; Herz J. 2009. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4(9):e6922. [PubMed: 19742316]  [MGI Ref ID J:153626]

de Haan W; Out R; Berbee JF; van der Hoogt CC; van Dijk KW; van Berkel TJ; Romijn JA; Jukema JW; Havekes LM; Rensen PC. 2008. Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo. Biochem Biophys Res Commun 377(4):1294-8. [PubMed: 18992221]  [MGI Ref ID J:143183]

van Vlijmen BJ; Rohlmann A; Page ST; Bensadoun A; Bos IS; van Berkel TJ; Havekes LM; Herz J. 1999. An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins. J Biol Chem 274(49):35219-26. [PubMed: 10575007]  [MGI Ref ID J:58704]

van der Hoogt CC; Berbee JF; Espirito Santo SM; Gerritsen G; Krom YD; van der Zee A; Havekes LM; van Dijk KW; Rensen PC. 2006. Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice. Biochim Biophys Acta 1761(2):213-20. [PubMed: 16478678]  [MGI Ref ID J:110564]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony homozygous mice may be bred together.
Mating SystemHomozygote x Homozygote         (Female x Male)   02-NOV-11

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Lrp1tm2Her  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Lrp1tm2Her x Homozygous for Lrp1tm2Her  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Lrp1tm2Her  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Lrp1tm2Her x Homozygous for Lrp1tm2Her  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)